AP2001002113A0 - Neuroimmunophilins for selective neuronal radioprotection. - Google Patents

Neuroimmunophilins for selective neuronal radioprotection.

Info

Publication number
AP2001002113A0
AP2001002113A0 APAP/P/2001/002113A AP2001002113A AP2001002113A0 AP 2001002113 A0 AP2001002113 A0 AP 2001002113A0 AP 2001002113 A AP2001002113 A AP 2001002113A AP 2001002113 A0 AP2001002113 A0 AP 2001002113A0
Authority
AP
ARIPO
Prior art keywords
neuroimmunophilins
radioprotection
selective neuronal
ionizing radiation
selectively protecting
Prior art date
Application number
APAP/P/2001/002113A
Inventor
Marcus Keep
Eskil Elmer
Original Assignee
Marcus Keep
Eskil Elmer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Marcus Keep, Eskil Elmer filed Critical Marcus Keep
Publication of AP2001002113A0 publication Critical patent/AP2001002113A0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

A method and pharmaceuticals for selectively protecting neurons against ionizing radiation induced damage, irrespective of the source of radiation insult. This method is particularly useful in selectively protecting normal neurons, but not brain tumor cells, against the damaging effects of ionizing radiation.
APAP/P/2001/002113A 1998-09-23 1998-09-23 Neuroimmunophilins for selective neuronal radioprotection. AP2001002113A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1998/020040 WO2000016794A1 (en) 1998-09-23 1998-09-23 Neuroimmunophilins for selective neuronal radioprotection

Publications (1)

Publication Number Publication Date
AP2001002113A0 true AP2001002113A0 (en) 2001-06-30

Family

ID=22267931

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/2001/002113A AP2001002113A0 (en) 1998-09-23 1998-09-23 Neuroimmunophilins for selective neuronal radioprotection.

Country Status (10)

Country Link
EP (1) EP1115412A4 (en)
JP (1) JP2002526453A (en)
CN (1) CN1322136A (en)
AP (1) AP2001002113A0 (en)
AU (1) AU766095B2 (en)
BR (1) BR9816047A (en)
CA (1) CA2345378A1 (en)
HK (1) HK1040617A1 (en)
IL (1) IL142120A0 (en)
WO (1) WO2000016794A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1568192A (en) * 2000-10-31 2005-01-19 法马马有限公司 Kahalalide F formulation
WO2005103255A1 (en) * 2004-03-25 2005-11-03 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Formylpeptide receptor (fpr) as a target for anti-malignant glioma therapy
WO2019232227A1 (en) * 2018-05-30 2019-12-05 Zap Surgical Systems, Inc. Radiosurgical neuromodlation close to critical structures

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE520730C2 (en) * 1995-01-20 2003-08-19 Eskil Elmer Treatment of brain ischemia and brain damage with a neuroprotective drug
JP3089350B2 (en) * 1995-11-20 2000-09-18 ギルフォード ファーマシューティカルズ インコーポレイテッド Inhibitors of cyclophilin rotamase activity

Also Published As

Publication number Publication date
JP2002526453A (en) 2002-08-20
IL142120A0 (en) 2002-03-10
CN1322136A (en) 2001-11-14
BR9816047A (en) 2003-01-07
HK1040617A1 (en) 2002-06-21
EP1115412A4 (en) 2004-12-15
AU9508198A (en) 2000-04-10
AU766095B2 (en) 2003-10-09
EP1115412A1 (en) 2001-07-18
WO2000016794A1 (en) 2000-03-30
CA2345378A1 (en) 2000-03-30

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