ZA200805063B - Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-c]pyridin-3-yl]-1,2-dioxoethyl]-piperazine - Google Patents
Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-c]pyridin-3-yl]-1,2-dioxoethyl]-piperazineInfo
- Publication number
- ZA200805063B ZA200805063B ZA200805063A ZA200805063A ZA200805063B ZA 200805063 B ZA200805063 B ZA 200805063B ZA 200805063 A ZA200805063 A ZA 200805063A ZA 200805063 A ZA200805063 A ZA 200805063A ZA 200805063 B ZA200805063 B ZA 200805063B
- Authority
- ZA
- South Africa
- Prior art keywords
- methyl
- dioxoethyl
- phosphonooxy
- pyrrolo
- triazol
- Prior art date
Links
- SWMDAPWAQQTBOG-UHFFFAOYSA-N fostemsavir Chemical compound C1=2N(COP(O)(O)=O)C=C(C(=O)C(=O)N3CCN(CC3)C(=O)C=3C=CC=CC=3)C=2C(OC)=CN=C1N1C=NC(C)=N1 SWMDAPWAQQTBOG-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- AIDS & HIV (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75024705P | 2005-12-14 | 2005-12-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200805063B true ZA200805063B (en) | 2009-10-28 |
Family
ID=38163502
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200805063A ZA200805063B (en) | 2005-12-14 | 2008-06-10 | Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-c]pyridin-3-yl]-1,2-dioxoethyl]-piperazine |
Country Status (17)
Country | Link |
---|---|
US (1) | US7851476B2 (no) |
EP (1) | EP1963342A2 (no) |
JP (1) | JP5400387B2 (no) |
KR (1) | KR20080077010A (no) |
CN (1) | CN101365708B (no) |
AU (1) | AU2006326432B2 (no) |
BR (1) | BRPI0619851A2 (no) |
CA (1) | CA2635717A1 (no) |
EA (1) | EA014706B1 (no) |
GE (1) | GEP20125413B (no) |
IL (1) | IL191769A (no) |
MY (1) | MY144293A (no) |
NO (1) | NO20082477L (no) |
NZ (2) | NZ592684A (no) |
UA (1) | UA94928C2 (no) |
WO (1) | WO2007070589A2 (no) |
ZA (1) | ZA200805063B (no) |
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US20040110785A1 (en) * | 2001-02-02 | 2004-06-10 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
US7745625B2 (en) * | 2004-03-15 | 2010-06-29 | Bristol-Myers Squibb Company | Prodrugs of piperazine and substituted piperidine antiviral agents |
ES2389478T3 (es) * | 2008-06-25 | 2012-10-26 | Bristol-Myers Squibb Company | Derivados de dicetopiperidina como inhibidores de la fijación del VIH |
US7960406B2 (en) * | 2008-06-25 | 2011-06-14 | Bristol-Myers Squibb Company | Diketo substituted pyrrolo[2,3-c] pyridines |
PT2323633E (pt) * | 2008-09-04 | 2012-05-29 | Bristol Myers Squibb Co | Composição farmacêutica estável para a administração optimizada de um inibidor de união de hiv |
WO2012075235A1 (en) | 2010-12-02 | 2012-06-07 | Bristol-Myers Squibb Company | Alkyl amides as hiv attachment inhibitors |
CN103339130B (zh) * | 2011-01-31 | 2015-05-06 | 百时美施贵宝公司 | 制备hiv附着抑制剂前药化合物的方法及中间体 |
WO2012142080A1 (en) | 2011-04-12 | 2012-10-18 | Bristol-Myers Squibb Company | Thioamide, amidoxime and amidrazone derivatives as hiv attachment inhibitors |
ES2609579T3 (es) | 2011-08-29 | 2017-04-21 | VIIV Healthcare UK (No.5) Limited | Derivados espiro de diamina bicíclica como inhibidores de la unión del VIH |
ES2616268T3 (es) | 2011-08-29 | 2017-06-12 | VIIV Healthcare UK (No.5) Limited | Derivados condensados de diamina bicíclica como inhibidores de la unión de VIH |
US9193725B2 (en) | 2012-03-14 | 2015-11-24 | Bristol-Meyers Squibb Company | Cyclic hydrazine derivatives as HIV attachment inhibitors |
US9505752B2 (en) | 2012-08-09 | 2016-11-29 | Viiv Healthcare Uk (No. 5) Limited | Piperidine amide derivatives as HIV attachment inhibitors |
WO2014025852A1 (en) | 2012-08-09 | 2014-02-13 | Bristol-Myers Squibb Company | Tricyclic alkene derivatives as hiv attachment inhibitors |
RU2663466C1 (ru) * | 2017-03-20 | 2018-08-06 | Общество с ограниченной ответственностью "МБА-групп" | Композиция для профилактики и/или лечения вич-инфекции |
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US20060100432A1 (en) | 2004-11-09 | 2006-05-11 | Matiskella John D | Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione |
US20060100209A1 (en) | 2004-11-09 | 2006-05-11 | Chong-Hui Gu | Formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione |
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US7501419B2 (en) | 2006-04-25 | 2009-03-10 | Bristol-Myers Squibb Company | 4-Squarylpiperazine derivatives as antiviral agents |
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-
2006
- 2006-12-11 US US11/636,755 patent/US7851476B2/en active Active
- 2006-12-13 AU AU2006326432A patent/AU2006326432B2/en active Active
- 2006-12-13 NZ NZ592684A patent/NZ592684A/en unknown
- 2006-12-13 NZ NZ568776A patent/NZ568776A/en unknown
- 2006-12-13 EA EA200801529A patent/EA014706B1/ru not_active IP Right Cessation
- 2006-12-13 EP EP06848592A patent/EP1963342A2/en not_active Withdrawn
- 2006-12-13 JP JP2008545772A patent/JP5400387B2/ja active Active
- 2006-12-13 WO PCT/US2006/047571 patent/WO2007070589A2/en active Application Filing
- 2006-12-13 CA CA002635717A patent/CA2635717A1/en not_active Abandoned
- 2006-12-13 MY MYPI20082090A patent/MY144293A/en unknown
- 2006-12-13 CN CN2006800472167A patent/CN101365708B/zh active Active
- 2006-12-13 BR BRPI0619851-1A patent/BRPI0619851A2/pt not_active Application Discontinuation
- 2006-12-13 UA UAA200809079A patent/UA94928C2/ru unknown
- 2006-12-13 KR KR1020087016884A patent/KR20080077010A/ko not_active Application Discontinuation
- 2006-12-13 GE GEAP200610811A patent/GEP20125413B/en unknown
-
2008
- 2008-05-27 IL IL191769A patent/IL191769A/en active IP Right Grant
- 2008-05-29 NO NO20082477A patent/NO20082477L/no not_active Application Discontinuation
- 2008-06-10 ZA ZA200805063A patent/ZA200805063B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
NZ568776A (en) | 2011-06-30 |
NO20082477L (no) | 2008-09-05 |
AU2006326432B2 (en) | 2012-07-12 |
US7851476B2 (en) | 2010-12-14 |
EP1963342A2 (en) | 2008-09-03 |
EA200801529A1 (ru) | 2009-02-27 |
CA2635717A1 (en) | 2007-06-21 |
US20070155702A1 (en) | 2007-07-05 |
NZ592684A (en) | 2012-07-27 |
MY144293A (en) | 2011-08-29 |
CN101365708A (zh) | 2009-02-11 |
AU2006326432A1 (en) | 2007-06-21 |
BRPI0619851A2 (pt) | 2011-10-25 |
KR20080077010A (ko) | 2008-08-20 |
UA94928C2 (en) | 2011-06-25 |
WO2007070589A2 (en) | 2007-06-21 |
EA014706B1 (ru) | 2011-02-28 |
JP5400387B2 (ja) | 2014-01-29 |
WO2007070589A3 (en) | 2007-09-27 |
IL191769A (en) | 2011-08-31 |
GEP20125413B (en) | 2012-03-12 |
JP2009521414A (ja) | 2009-06-04 |
IL191769A0 (en) | 2008-12-29 |
CN101365708B (zh) | 2012-12-12 |
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