WO2019104205A1 - Intranasal device with dip tube - Google Patents
Intranasal device with dip tube Download PDFInfo
- Publication number
- WO2019104205A1 WO2019104205A1 PCT/US2018/062296 US2018062296W WO2019104205A1 WO 2019104205 A1 WO2019104205 A1 WO 2019104205A1 US 2018062296 W US2018062296 W US 2018062296W WO 2019104205 A1 WO2019104205 A1 WO 2019104205A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- tip
- compound
- propellant
- compound container
- cavity
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 claims abstract description 94
- 239000003380 propellant Substances 0.000 claims abstract description 72
- 239000012530 fluid Substances 0.000 claims abstract description 22
- 238000004891 communication Methods 0.000 claims abstract description 19
- 210000003928 nasal cavity Anatomy 0.000 claims abstract description 10
- 239000007788 liquid Substances 0.000 claims description 18
- 238000003780 insertion Methods 0.000 claims description 4
- 230000037431 insertion Effects 0.000 claims description 4
- 238000007789 sealing Methods 0.000 claims description 3
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 239000002985 plastic film Substances 0.000 claims 1
- 229920006255 plastic film Polymers 0.000 claims 1
- 239000003708 ampul Substances 0.000 description 13
- 150000005828 hydrofluoroalkanes Chemical class 0.000 description 9
- 239000000203 mixture Substances 0.000 description 7
- 210000003169 central nervous system Anatomy 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 229940071648 metered dose inhaler Drugs 0.000 description 4
- 210000001331 nose Anatomy 0.000 description 4
- 239000003570 air Substances 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 238000009434 installation Methods 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 238000000151 deposition Methods 0.000 description 2
- 238000006073 displacement reaction Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000012377 drug delivery Methods 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 230000013011 mating Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- YFMFNYKEUDLDTL-UHFFFAOYSA-N 1,1,1,2,3,3,3-heptafluoropropane Chemical compound FC(F)(F)C(F)C(F)(F)F YFMFNYKEUDLDTL-UHFFFAOYSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 239000012080 ambient air Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 210000000887 face Anatomy 0.000 description 1
- 239000003168 generic drug Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000007923 nasal drop Substances 0.000 description 1
- 239000007922 nasal spray Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 210000001944 turbinate Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/08—Inhaling devices inserted into the nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/02—Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0021—Mouthpieces therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
- A61M15/0035—Piercing means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
- A61M15/0035—Piercing means
- A61M15/0036—Piercing means hollow piercing means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0086—Inhalation chambers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B9/00—Spraying apparatus for discharge of liquids or other fluent material, without essentially mixing with gas or vapour
- B05B9/03—Spraying apparatus for discharge of liquids or other fluent material, without essentially mixing with gas or vapour characterised by means for supplying liquid or other fluent material
- B05B9/04—Spraying apparatus for discharge of liquids or other fluent material, without essentially mixing with gas or vapour characterised by means for supplying liquid or other fluent material with pressurised or compressible container; with pump
- B05B9/08—Apparatus to be carried on or by a person, e.g. of knapsack type
- B05B9/0805—Apparatus to be carried on or by a person, e.g. of knapsack type comprising a pressurised or compressible container for liquid or other fluent material
- B05B9/0833—Apparatus to be carried on or by a person, e.g. of knapsack type comprising a pressurised or compressible container for liquid or other fluent material comprising a compressed gas container, e.g. a nitrogen cartridge
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B9/00—Spraying apparatus for discharge of liquids or other fluent material, without essentially mixing with gas or vapour
- B05B9/03—Spraying apparatus for discharge of liquids or other fluent material, without essentially mixing with gas or vapour characterised by means for supplying liquid or other fluent material
- B05B9/04—Spraying apparatus for discharge of liquids or other fluent material, without essentially mixing with gas or vapour characterised by means for supplying liquid or other fluent material with pressurised or compressible container; with pump
- B05B9/08—Apparatus to be carried on or by a person, e.g. of knapsack type
- B05B9/0805—Apparatus to be carried on or by a person, e.g. of knapsack type comprising a pressurised or compressible container for liquid or other fluent material
- B05B9/0838—Apparatus to be carried on or by a person, e.g. of knapsack type comprising a pressurised or compressible container for liquid or other fluent material supply being effected by follower in container, e.g. membrane or floating piston, or by deformation of container
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/582—Means for facilitating use, e.g. by people with impaired vision by tactile feedback
Definitions
- the device includes an actuator body and a tip configured to removably couple to the actuator body.
- the actuator body comprises a propellant channel that is configured to be in fluid communication with a canister containing a propellant.
- the tip comprises a tip stem, a dip tube, a delivery channel, one or more puncture members, and an outlet orifice.
- the tip stem comprises a cavity and an opening such that the cavity is in fluid communication with the propellant channel, where the cavity is configured to receive a compound container containing the compound and where the compound container is configured to move between a sealed state and an unsealed state within the cavity.
- the dip tube is positioned within the cavity, and the dip tube comprises the delivery channel that extends from a proximal end to a distal end of the dip tube.
- the one or more puncture members are each configured to puncture the compound container when the shuttle is in the unsealed state such that the punctured compound container is in fluid communication with the propellant channel and the delivery channel.
- the outlet orifice is in fluid communication with the delivery channel, such that propellant released from the canister travels through the propellant channel and into the cavity, through the plurality of openings and into the compound container, thereby contacting the compound and propelling the compound through the delivery channel and out the outlet orifice.
- At least one puncture member is disposed at a distal end of the dip tube.
- the device further comprises a collar that includes one or more of the puncture members, where the collar includes one or more bypass openings that are in fluid communication with the propellant channel such that released propellant is introduced into the compound container.
- the puncture member(s) of the dip tube puncture the compound container first, and the puncture member(s) of the collar puncture the compound container second.
- FIG. 1 illustrates an intranasal drug delivery device, in accordance with one or more embodiments.
- FIGS. 2A and 2B illustrate a tip of the device and a tip cone, in accordance with one or more embodiments.
- FIGS. 3 A and 3B illustrate a cross-sectional view of the tip, in accordance with one or more embodiments.
- FIG. 4 illustrates a tip stem, in accordance with one or more embodiments.
- FIG. 5 illustrates a shuttle, in accordance with one or more embodiments.
- FIG. 6 illustrates a compound container, in accordance with one or more embodiments.
- FIG. 7 illustrates a dip tube, in accordance with one or more embodiments.
- FIG. 8 illustrates a collar, in accordance with one or more embodiments.
- FIG. 9 illustrates a nozzle, in accordance with one or more embodiments.
- FIG. 10 illustrates an actuator body, in accordance with one or more
- FIG. 11 illustrates a canister containing a propellant, in accordance with one or more embodiments.
- FIG. 1 illustrates an intranasal drug delivery device 100, in accordance with one or more embodiments.
- the device 100 is designed to deliver a consistent mass of compound into the nasal cavity.
- the compound may be an intranasal formulation in a liquid or suspension form.
- the device 100 targets a specific region of the nasal cavity utilizing a narrow, targeted delivery plume. Specifically, the device 100 provides the compound to the upper one third of the nasal cavity.
- the device 100 is used to administer the compound into the olfactory region of a human.
- the device 100 is designed to receive a compound container containing the compound.
- the device 100 may be re-used to administer several doses of the compound. In the embodiment of FIG.
- the device 100 includes an actuator body 105, a propellant canister 110, a tip 115, and a release button 120.
- the actuator body 105 is designed to be held in a hand of a user for administering the compound to an olfactory region of the user.
- the actuator body 105 comprises a cavity for receiving the canister 110 and a neck 125 for receiving the tip 115.
- the actuator body 105 comprises a propellant channel (not shown) having a first end that couples to the canister 110 and a second end that couples to the tip 115 such that the tip 115 is in fluid communication with the canister 110.
- a propellant channel not shown
- the neck 125 comprises the release button 120, which enables the tip 115 to be coupled and decoupled to the actuator body 105. As shown in FIG. 1, the tip 115 is inserted into the neck 125, while in other embodiments, the neck 125 may be inserted into the tip 115. In some embodiments, the neck 125 and/or the tip 115 may include a sealing interface that creates an airtight seal between the propellant channel and the tip 115 such that propellant released from the canister 110 does not escape out of the propellant channel and is directed into the tip 115.
- the propellant canister 110 is positioned within the actuator body 105.
- the propellant canister 110 contains propellant.
- the propellant may be pressurized.
- the propellant is a fluid, for example, a liquid or gas.
- the propellant is a liquid.
- the propellant is a gas.
- Propellants include pharmaceutically suitable propellants. Some examples of pharmaceutically suitable propellants include hydrofluoroalkane (HFA) including but not limited to HFA, HFA 227, HFA l34a, HFA-FP, HFA-BP and the like HFA's.
- HFA hydrofluoroalkane
- the propellant is liquid HFA.
- the propellant is gaseous HFA.
- propellants include nitrogen or chloroflourocarbons (CFC). Additionally, propellants may be pressurized air (e.g. ambient air).
- the canister 110 may be a metered dose inhaler (MDI) device that includes a pressurized canister and metering valve (including stem) (shown in FIG. 11) to meter the propellant upon actuation.
- MDI metered dose inhaler
- a pump fitment (not shown) secures the metering valve to the canister 110 and holds both components in place during device 100 use.
- One series of embodiments of the pump fitment consists of securing interfaces that retain the pump fitment within the actuator body 105, provide vertical displacement, and prevent rotation during installation of the canister 110.
- the propellant canister 110 may have a capacity for distributing propellant for a certain number of doses.
- the device 100 may be shipped without a canister 110 and the canister 110 may be loaded into the actuator body 105 by the user.
- the canister 110 may be replaced with a new propellant canister, such that the device 100 may be reused.
- a discrete amount of pressurized HFA fluid is released.
- the MDI may contain between about 30 to about 300 actuations, inclusive of endpoints, of HFA propellant.
- the amount of fluid propellant released upon actuation may be between about 20 pi and about 200 m ⁇ inclusive of endpoints, of liquid propellant.
- the tip 115 delivers the compound to the olfactory region of the user.
- the tip 115 includes a tip stem (shown in FIG. 2A) and a tip cone 130.
- the tip 115 may be coupled and decoupled to the actuator body 105 by inserting the tip stem into the neck 125 of the actuator body 105, which enables a user to load and unload a compound container into and from the tip 115.
- the compound container may be inserted into a shuttle (shown in FIG. 6) that is inserted into the tip 115.
- the shuttle may protect the compound container, which may be, for example, a liquid dose capsule.
- the tip cone 130 is positioned within a nostril of the user for aiming the delivery of the compound to the olfactory region.
- the tip 115 is discussed in further detail with regard to FIGS. 2A-2B.
- FIGS. 2A and 2B illustrate the tip 115 of the device and the tip cone 130, in accordance with one or more embodiments.
- the tip 115 includes the tip cone 130 and the tip stem 205.
- the tip cone 130 and the tip stem 205 may be coupled and decoupled from each other for loading and unloading a compound container into and from the tip stem 205.
- the tip stem 205 is the first half of the tip 115 body.
- the tip stem 205 seals on the proximal end to the tip cone 130 during assembly.
- the tip stem 205 is installed into the actuator neck 125 and may have a tapered cylindrical face for inserting into the actuator 125.
- a seal is formed between the external surface of the tip stem 205 and an internal surface of the actuator neck 125, allowing the tip 115 to become pressurized.
- the seal may be formed by a sealing interface, an interference fit, or some combination thereof.
- the tip stem 205 includes one or more slots 210 on a tapered surface of the tip stem 205, also shown in FIG. 4.
- the slots 210 are designed to interface with ribs on the internal surface of the actuator neck 125.
- the slots may ensure proper rotational alignment of the tip 115 relative to the actuator body 105.
- inserting the tip 115 into the actuator neck 125 also causes the ribs to drive a shuttle (not shown) housed within the tip stem 205 forward towards the tip cone 130.
- the slots 210 are also in fluid communication with the propellant channel such that released propellant travels into the tip stem 205.
- the tip cone 130 is the second half of the tip 115 body.
- the larger end of the tip cone 130 is joined and sealed to the tip stem 205.
- the tip cone 130 is designed to receive a dip tube, a collar, and a nozzle, which will be discussed in regard to FIGS. 3A and 3B.
- the external geometries of the tip cone 130 provide proper alignment of the tip 115 during insertion into the nostril of the user.
- a flat side of the tip 115 (not shown) lies parallel to and against the septum, with a depth stop guard 215 providing correct depth of insertion.
- the tip 115 can be installed in either a left or right orientation on the actuator neck 125, allowing dosing into both sides of the nose with the same tip design.
- One or more side openings 220 on a skirt 225 of the tip cone 130 receive reciprocal clip features of the actuator neck 125. Drafted faces on the tip cone 130 lead the clip features towards the side openings 220, which keeps installation forces low, while the clip features having a ledge in a removal direction of the tip 115 restricts the tip 115 from ejecting during use.
- the clip features also provide the user tactile feedback to confirm the tip 115 is fully installed.
- the clip features of the actuator neck 125 are coupled or directly connected to the release button 120 such that the tip 115 may be decoupled from the actuator neck 125 upon actuation of the release button 120.
- FIGS. 3A and 3B illustrate a cross-sectional view of the tip 115, in accordance with one or more embodiments.
- the tip 115 includes the tip cone 130, the tip stem 205, a shuttle 305, a dip tube 310, a delivery channel 315, a collar 320, a nozzle 325, a nozzle channel 330, and an outlet orifice 335.
- the shuttle 305 houses a compound container 340 containing the compound and moves between a sealed state (shown in FIG. 3A), where the compound container 340 is sealed, and an unsealed state (shown in FIG.
- the dip tube 310 includes a puncture member 350 that punctures the compound container 340 such that the compound container 340 is in fluid communication with the delivery channel 315, which is in fluid communication with the nozzle channel 330, the nozzle 325, and the outlet orifice 335.
- the collar 320 includes a puncture member (not shown) that punctures the compound container 340 such that the compound container is in fluid communication with the propellant channel, such that propellant released from the canister 110 travels through the propellant channel and into the compound container 340, thereby contacting the compound and propelling the compound through the delivery channel 315 and the nozzle 325 and out the outlet orifice 335.
- the shuttle 305 receives the compound container containing the compound.
- the compound container may be a blow fill sealed (BFS) ampoule.
- BFS ampoule is a polyethylene liquid dose capsule, and in other embodiments, the ampoule may be composed of other types of suitable plastic.
- a film is blow molded into a defined geometry, filled with a designated liquid dose, and sealed.
- the ampoule provides a liquid and vapor barrier for the intranasal formulation within.
- the BFS ampoule containing the liquid dose also shown in FIG. 6, is installed into the shuttle 305, also shown in FIG. 5, which is in turn installed into the tip stem 205.
- FIG. 3A illustrates the shuttle 305 positioned within a cavity 345 of the tip stem 205 in the sealed state, where the shuttle 305 is at a distal end of the cavity 345 and the compound container 340 is sealed.
- FIG. 3B illustrates the shuttle 305 positioned within the cavity 345 of the tip stem 205 in the unsealed state, where the shuttle 305 is at a proximal end of the cavity 345 and the compound container 340 has been punctured by the puncture member 350 of the dip tube 310 and the puncture member(s) of the collar 320. Inserting the tip 115 into the actuator neck 125 causes ribs on the internal surface of the actuator neck 125 to drive the shuttle 305 forward towards the tip cone 130, moving the shuttle 305 from the sealed state to the unsealed state.
- the shuttle and the BFS ampoule are punctured by the puncture member 350 of the dip tube 310 and the puncture member(s) of the collar 320, thereby breaking the seal of the BFS ampoule and providing a flow path for the liquid dose to be evacuated from the BFS ampoule.
- an outer surface of the shuttle 305 rides on ribs on an internal surface of the tip stem 205.
- the shuttle 305 provides a rigid body for the ribs on the internal surface of the actuator neck 125 to press against to propel the shuttle 305 forward towards the proximal end of the tip 115, rather than pushing directly onto the flexible BFS ampoule itself.
- the shuttle 305 may have internal support features (e.g., ribs, notches, or the like) (not shown) to support the BFS ampoule, in one example concentrically, so that the BFS ampoule may be punctured.
- the splayed lips on the proximal end of the shuttle 305 prevent the shuttle 305 from being inserted backwards into the tip stem 205. Additionally, the splayed lips 505 ensure that the shuttle 305 and the tip stem 205 will be in interference across tolerance ranges. The shuttle 305 also shields the dose containing BFS ampoule from sight, limiting light exposure, device tampering, or premature ampoule puncture from external objects.
- the dip tube 310 is positioned within the cavity 345 of the tip stem 205.
- the dip tube 310 also shown in FIG. 7, includes a delivery channel 315 that extends from a proximal end to a distal end of the dip tube 310.
- the delivery channel 315 is in fluid communication with the nozzle channel 330, the nozzle 325, and the outlet orifice 335.
- the dip tube 310 includes a puncture member 350 about the distal end of the dip tube 310.
- the puncture member 350 is an angled edge about the distal end of the dip tube 310.
- the dip tube 310 may include more than one puncture member at the distal end, and the shape and/or angle of the puncture member may vary.
- the puncture member 350 punctures the compound container 340 as the shuttle 305 is driven towards the nose cone 130 from the sealed state to the unsealed state by the ribs on the internal surface of the actuator neck 125. In this configuration, the dip tube punctures through the compound container 340 and seats inside the compound container 340 (e.g., near the base of the compound container 340).
- the dip tube 310 may have external walls that taper such that the punctured hole in the compound container 340 created by the puncture member 350 is smaller than the diameter of the dip tube 310, thereby creating a water and gas-tight seal between the dip tube 310 and the compound container 340.
- the tapered walls may also increase the rigidity of the puncture member 350.
- a protruding ring feature 355 on the proximal end of the dip tube 310 provides a mating interface for mating with the nozzle channel 330.
- An interference fit between the protruding ring feature 355 of the dip tube 310 and the nozzle channel 330 may seal the components such that the delivery channel 315 and the nozzle channel 330 are in fluid communication.
- the collar 320 is positioned about the proximal end of the dip tube 310 within the tip cone 130.
- the collar 320 is designed to puncture the compound container 340 to create a flow path between the propellant channel and the compound container 340 such that propellant released from the canister 110 flows into the punctured compound container 340.
- the collar 320 includes a central opening 805, one or more bypass openings 810, and one or more puncture members 815.
- the one or more puncture members 815 are on a bottom surface of the collar 320.
- the collar 320 is installed over the dip tube 310, where the central opening 805 mates with the protruding ring feature 355 of the dip tube 310 and forms a seal to hold the collar in place.
- the collar 320 is oriented such that the puncture members 815 are oriented towards the compound container 340.
- the compound container 340 is punctured first by the dip tube 310 and second by the collar 320.
- the collar 320 seats into the top of the compound container 340.
- the bypass openings 810 around the perimeter of the collar 320 introduce propellant into the compound container during device 100 actuation. Any dose displaced into the collar 320 during puncture of the compound container 340 is forced back into the compound container 340 by the propellant. In this manner, the dose and the propellant are mixed together in the container 340 and then evacuated through the dip tube 310 during device 100 actuation.
- the nozzle 325 directs the spray of propellant and dose from the nozzle channel 330 and out the outlet orifice 335 such that the spray is targeted towards the olfactory region of a user.
- the nozzle 325 may form a narrow plume.
- the nozzle 325 is positioned within the nozzle channel 330 of the tip cone 130. In the embodiment of FIG. 3, the nozzle 325 is at the proximal end of the tip cone 130, adjacent to the outlet orifice 335.
- the nozzle 325 may include one or more channels 905 that may be oriented parallel to a central axis of the nozzle 325 or tapered towards or away from the central axis.
- the nozzle channel 330 connecting the nozzle 325 and the dip tube 310 may serve as a displacement volume for the liquid dose during puncture of the compound container.
- the nozzle 325 forms a liquid and gas-tight seal around the outer diameter within the nozzle channel 330.
- propellant evacuates liquid dose from the compound container 340, pushing it through the nozzle channel 330 and out the nozzle 325.
- the type of nozzle 325 installed into the nozzle channel 330 may vary, which enables the device 100 to adapt to different formulation types or plume styles.
- the actuator body 105 couples the propellant canister 110, shown in FIGS. 1 and 11, to the tip 115.
- the propellant canister 110 seats and seals inside a large upright cavity of the actuator body 105.
- the tip 115 is inserted into the neck 125 of the actuator body 105.
- Internal ribs (not shown) on the internal surface of the actuator neck 125 contact the compound container 340 and drive the compound container 340 towards the puncture members on the dip tube 310 and the collar 320.
- the actuator neck 125 seals to the tip 115 to pressurize the tip 115.
- clips near the end of the actuator neck 125 interface with the tip cone during use.
- the propellant canister 110 provides the propulsion for the device.
- the canister 110 is inserted into the actuator body 105.
- the canister 110 is depressed, releasing a metered volume of liquid propellant.
- the propellant vaporizes and expands, the propellant travels through the propellant channel of the actuator body and into the tip stem 205 through the slots 210. Since the tip stem 205 is pressurized, the propellant forces the liquid dose out of the compound container 340 and out through the nozzle 325 and the outlet orifice 335.
- the propellant fills the tip stem (e.g., traveling through the cavity 345, through the bypass openings 810, into the nose cone 130), such that the displaced air volume forces the liquid dose out of the compound container 340.
- the propellant fills the tip stem 205 and then enters the compound container 340 through the punctured openings, where the propellant and compound mix together before exiting through the outlet orifice 335.
- the canister 110 may contain enough propellant for multiple doses. Propellant type and volume may be selected by one of skill in the art based on performance data.
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Abstract
A device for delivering a compound to the olfactory region of the nasal cavity includes an actuator body and a tip configured to removably couple to the actuator body. The actuator body comprises a propellant channel in fluid communication with a propellant canister. The tip comprises a tip stem, a dip tube, a delivery channel, one or more puncture members, and an outlet orifice. The tip stem receives a compound container containing the compound and the compound container moves between a sealed state and an unsealed state. The one or more puncture members are each configured to puncture the compound container when the compound container is in the unsealed state. Propellant released from the canister travels through the propellant channel and into the punctured compound container, thereby contacting the compound and propelling the compound through the delivery channel and out the outlet orifice.
Description
INTRANASAL DEVICE WITH DIP TUBE
CROSS-REFERENCE TO RELATED APPLICATION
[0001] This application claims the benefit of U.S. Provisional Application No.
62/589,306, filed on November 21, 2017, which is herein incorporated by reference in its entirety.
BACKGROUND
[0002] Depositing drug on the olfactory region of the nasal cavity is difficult to accomplish due to the complex architecture of the nasal cavity and the turbinate guided air path for inhaled breath through the nose. These natural structures act to prevent materials from depositing on the olfactory region as a way to protect this entry way into the central nervous system (CNS). Existing nasal drop or spray devices are designed to saturate the lower nasal cavity. Drug deposited on the lower nasal cavity is absorbed into the blood stream instead of the CNS, eliminating an advantage of using the nasal route for CNS delivery.
[0003] A more elegant approach to the intranasal delivery of compounds or mixtures is needed.
SUMMARY
[0004] A device for delivering a compound to the olfactory region of the nasal cavity is described. In one embodiment, the device includes an actuator body and a tip configured to removably couple to the actuator body. The actuator body comprises a propellant channel that is configured to be in fluid communication with a canister containing a propellant. The tip comprises a tip stem, a dip tube, a delivery channel, one or more puncture members, and an outlet orifice. The tip stem comprises a cavity and an opening such that the cavity is in fluid communication with the propellant channel, where the cavity is configured to receive a compound container containing the compound and where the compound container is configured to move between a sealed state and an unsealed state within the cavity. The dip tube is positioned within the cavity, and the dip tube comprises the delivery channel that extends from a proximal end to a distal end of the dip tube. The one or more puncture members are each configured to puncture the compound container when the shuttle is in the unsealed state such that the punctured compound container is in fluid communication with the propellant channel and the delivery channel. The outlet orifice is in fluid communication with the delivery channel, such that propellant released from the canister travels through the propellant channel and into the cavity, through the plurality of openings and into the
compound container, thereby contacting the compound and propelling the compound through the delivery channel and out the outlet orifice.
[0005] In one embodiment, at least one puncture member is disposed at a distal end of the dip tube. In one embodiment, the device further comprises a collar that includes one or more of the puncture members, where the collar includes one or more bypass openings that are in fluid communication with the propellant channel such that released propellant is introduced into the compound container. In one embodiment, the puncture member(s) of the dip tube puncture the compound container first, and the puncture member(s) of the collar puncture the compound container second.
[0006] The invention will best be understood by reference to the following detailed description of various embodiments, taken in conjunction with any accompanying drawings. The discussion below is descriptive, illustrative and exemplary and is not to be taken as limiting the scope defined by any appended claims.
BRIEF DESCRIPTION OF THE DRAWINGS
[0007] Figure (FIG.) 1 illustrates an intranasal drug delivery device, in accordance with one or more embodiments.
[0008] FIGS. 2A and 2B illustrate a tip of the device and a tip cone, in accordance with one or more embodiments.
[0009] FIGS. 3 A and 3B illustrate a cross-sectional view of the tip, in accordance with one or more embodiments.
[0010] FIG. 4 illustrates a tip stem, in accordance with one or more embodiments.
[0011] FIG. 5 illustrates a shuttle, in accordance with one or more embodiments.
[0012] FIG. 6 illustrates a compound container, in accordance with one or more embodiments.
[0013] FIG. 7 illustrates a dip tube, in accordance with one or more embodiments.
[0014] FIG. 8 illustrates a collar, in accordance with one or more embodiments.
[0015] FIG. 9 illustrates a nozzle, in accordance with one or more embodiments.
[0016] FIG. 10 illustrates an actuator body, in accordance with one or more
embodiments.
[0017] FIG. 11 illustrates a canister containing a propellant, in accordance with one or more embodiments.
[0018] The figures depict embodiments of the present disclosure for purposes of illustration only. One skilled in the art will readily recognize from the following description
that alternative embodiments of the structures and methods illustrated herein may be employed without departing from the principles, or benefits touted, of the disclosure described herein.
[0019]
DETAILED DESCRIPTION
[0020] Unless stated otherwise, the following terms and phrases as used herein are intended to have the following meanings:
[0021] When trade names are used herein, applicants intend to independently include the trade name product formulation, the generic drug, and the active pharmaceutical ingredient(s) of the trade name product.
[0022] For clarity of disclosure, and not by way of limitation, the detailed description of the invention is divided into the subsections which follow.
[0023] Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art pertinent to the methods and compositions described. The following references provide one of skill with a non-exclusive guide to a general definition of many of the terms used herein: Hale & Margham, The Harper Collins Dictionary of Biology (Harper Perennial, New York, N.Y., 1991); King & Stansfield, A Dictionary of Genetics (Oxford University Press, 4th ed. 1990); Hawley’s Condensed Chemical Dictionary (John Wiley & Sons, l3th ed. 1997); and Stedmans’ Medical Dictionary (Lippincott Williams & Wilkins, 27th ed. 2000). As used herein, the following terms and phrases have the meanings ascribed to them unless specified otherwise.
[0024] FIG. 1 illustrates an intranasal drug delivery device 100, in accordance with one or more embodiments. The device 100 is designed to deliver a consistent mass of compound into the nasal cavity. For example, but not limited to, the compound may be an intranasal formulation in a liquid or suspension form. The device 100 targets a specific region of the nasal cavity utilizing a narrow, targeted delivery plume. Specifically, the device 100 provides the compound to the upper one third of the nasal cavity. In one embodiment, the device 100 is used to administer the compound into the olfactory region of a human. The device 100 is designed to receive a compound container containing the compound. The device 100 may be re-used to administer several doses of the compound. In the embodiment of FIG. 1, the device 100 includes an actuator body 105, a propellant canister 110, a tip 115, and a release button 120.
[0025] The actuator body 105 is designed to be held in a hand of a user for administering the compound to an olfactory region of the user. In the embodiment of FIG. 1, the actuator body 105 comprises a cavity for receiving the canister 110 and a neck 125 for receiving the tip 115. The actuator body 105 comprises a propellant channel (not shown) having a first end that couples to the canister 110 and a second end that couples to the tip 115 such that the tip 115 is in fluid communication with the canister 110. In the embodiment of FIG. 1, the neck 125 comprises the release button 120, which enables the tip 115 to be coupled and decoupled to the actuator body 105. As shown in FIG. 1, the tip 115 is inserted into the neck 125, while in other embodiments, the neck 125 may be inserted into the tip 115. In some embodiments, the neck 125 and/or the tip 115 may include a sealing interface that creates an airtight seal between the propellant channel and the tip 115 such that propellant released from the canister 110 does not escape out of the propellant channel and is directed into the tip 115.
[0026] As shown in FIG. 1, the propellant canister 110 is positioned within the actuator body 105. The propellant canister 110 contains propellant. In one embodiment, the propellant may be pressurized. The propellant is a fluid, for example, a liquid or gas. In one aspect, the propellant is a liquid. In another aspect, the propellant is a gas. Propellants include pharmaceutically suitable propellants. Some examples of pharmaceutically suitable propellants include hydrofluoroalkane (HFA) including but not limited to HFA, HFA 227, HFA l34a, HFA-FP, HFA-BP and the like HFA's. In one aspect, the propellant is liquid HFA. In another aspect, the propellant is gaseous HFA. Additional examples of suitable propellants include nitrogen or chloroflourocarbons (CFC). Additionally, propellants may be pressurized air (e.g. ambient air). The canister 110 may be a metered dose inhaler (MDI) device that includes a pressurized canister and metering valve (including stem) (shown in FIG. 11) to meter the propellant upon actuation. In one embodiment, a pump fitment (not shown) secures the metering valve to the canister 110 and holds both components in place during device 100 use. One series of embodiments of the pump fitment consists of securing interfaces that retain the pump fitment within the actuator body 105, provide vertical displacement, and prevent rotation during installation of the canister 110.
[0027] The propellant canister 110 may have a capacity for distributing propellant for a certain number of doses. In one embodiment, the device 100 may be shipped without a canister 110 and the canister 110 may be loaded into the actuator body 105 by the user. In some embodiments, the canister 110 may be replaced with a new propellant canister, such that the device 100 may be reused. In one aspect, when the MDI device is actuated, a discrete amount of pressurized HFA fluid is released. The MDI may contain between about
30 to about 300 actuations, inclusive of endpoints, of HFA propellant. The amount of fluid propellant released upon actuation may be between about 20 pi and about 200 mΐ inclusive of endpoints, of liquid propellant.
[0028] The tip 115 delivers the compound to the olfactory region of the user. In the embodiment of FIG. 1, the tip 115 includes a tip stem (shown in FIG. 2A) and a tip cone 130. The tip 115 may be coupled and decoupled to the actuator body 105 by inserting the tip stem into the neck 125 of the actuator body 105, which enables a user to load and unload a compound container into and from the tip 115. In some embodiments, the compound container may be inserted into a shuttle (shown in FIG. 6) that is inserted into the tip 115.
The shuttle may protect the compound container, which may be, for example, a liquid dose capsule. The tip cone 130 is positioned within a nostril of the user for aiming the delivery of the compound to the olfactory region. The tip 115 is discussed in further detail with regard to FIGS. 2A-2B.
[0029] FIGS. 2A and 2B illustrate the tip 115 of the device and the tip cone 130, in accordance with one or more embodiments. In the embodiments of FIGS. 2A-2B, the tip 115 includes the tip cone 130 and the tip stem 205. The tip cone 130 and the tip stem 205 may be coupled and decoupled from each other for loading and unloading a compound container into and from the tip stem 205. As shown in FIG. 2A, the tip stem 205 is the first half of the tip 115 body. The tip stem 205 seals on the proximal end to the tip cone 130 during assembly. The tip stem 205 is installed into the actuator neck 125 and may have a tapered cylindrical face for inserting into the actuator 125. A seal is formed between the external surface of the tip stem 205 and an internal surface of the actuator neck 125, allowing the tip 115 to become pressurized. The seal may be formed by a sealing interface, an interference fit, or some combination thereof. In the embodiment of FIG. 2A, the tip stem 205 includes one or more slots 210 on a tapered surface of the tip stem 205, also shown in FIG. 4. The slots 210 are designed to interface with ribs on the internal surface of the actuator neck 125. The slots may ensure proper rotational alignment of the tip 115 relative to the actuator body 105. In this configuration, inserting the tip 115 into the actuator neck 125 also causes the ribs to drive a shuttle (not shown) housed within the tip stem 205 forward towards the tip cone 130. The slots 210 are also in fluid communication with the propellant channel such that released propellant travels into the tip stem 205.
[0030] As shown in FIG. 2B, the tip cone 130 is the second half of the tip 115 body. The larger end of the tip cone 130 is joined and sealed to the tip stem 205. The tip cone 130 is designed to receive a dip tube, a collar, and a nozzle, which will be discussed in regard to
FIGS. 3A and 3B. The external geometries of the tip cone 130 provide proper alignment of the tip 115 during insertion into the nostril of the user. In one example, a flat side of the tip 115 (not shown) lies parallel to and against the septum, with a depth stop guard 215 providing correct depth of insertion. The tip 115 can be installed in either a left or right orientation on the actuator neck 125, allowing dosing into both sides of the nose with the same tip design. One or more side openings 220 on a skirt 225 of the tip cone 130 receive reciprocal clip features of the actuator neck 125. Drafted faces on the tip cone 130 lead the clip features towards the side openings 220, which keeps installation forces low, while the clip features having a ledge in a removal direction of the tip 115 restricts the tip 115 from ejecting during use. The clip features also provide the user tactile feedback to confirm the tip 115 is fully installed. The clip features of the actuator neck 125 are coupled or directly connected to the release button 120 such that the tip 115 may be decoupled from the actuator neck 125 upon actuation of the release button 120.
[0031] FIGS. 3A and 3B illustrate a cross-sectional view of the tip 115, in accordance with one or more embodiments. In the embodiments of FIGS. 3A and 3B, the tip 115 includes the tip cone 130, the tip stem 205, a shuttle 305, a dip tube 310, a delivery channel 315, a collar 320, a nozzle 325, a nozzle channel 330, and an outlet orifice 335. In use, the shuttle 305 houses a compound container 340 containing the compound and moves between a sealed state (shown in FIG. 3A), where the compound container 340 is sealed, and an unsealed state (shown in FIG. 3B), where the compound container 340 has been punctured by the dip tube 310 and the collar 320. The dip tube 310 includes a puncture member 350 that punctures the compound container 340 such that the compound container 340 is in fluid communication with the delivery channel 315, which is in fluid communication with the nozzle channel 330, the nozzle 325, and the outlet orifice 335. The collar 320 includes a puncture member (not shown) that punctures the compound container 340 such that the compound container is in fluid communication with the propellant channel, such that propellant released from the canister 110 travels through the propellant channel and into the compound container 340, thereby contacting the compound and propelling the compound through the delivery channel 315 and the nozzle 325 and out the outlet orifice 335.
[0032] The shuttle 305 receives the compound container containing the compound. In some embodiments, the compound container may be a blow fill sealed (BFS) ampoule. In one example, the BFS ampoule is a polyethylene liquid dose capsule, and in other embodiments, the ampoule may be composed of other types of suitable plastic. A film is blow molded into a defined geometry, filled with a designated liquid dose, and sealed. The
ampoule provides a liquid and vapor barrier for the intranasal formulation within. The BFS ampoule containing the liquid dose, also shown in FIG. 6, is installed into the shuttle 305, also shown in FIG. 5, which is in turn installed into the tip stem 205. FIG. 3A illustrates the shuttle 305 positioned within a cavity 345 of the tip stem 205 in the sealed state, where the shuttle 305 is at a distal end of the cavity 345 and the compound container 340 is sealed.
FIG. 3B illustrates the shuttle 305 positioned within the cavity 345 of the tip stem 205 in the unsealed state, where the shuttle 305 is at a proximal end of the cavity 345 and the compound container 340 has been punctured by the puncture member 350 of the dip tube 310 and the puncture member(s) of the collar 320. Inserting the tip 115 into the actuator neck 125 causes ribs on the internal surface of the actuator neck 125 to drive the shuttle 305 forward towards the tip cone 130, moving the shuttle 305 from the sealed state to the unsealed state. In the unsealed state, the shuttle and the BFS ampoule are punctured by the puncture member 350 of the dip tube 310 and the puncture member(s) of the collar 320, thereby breaking the seal of the BFS ampoule and providing a flow path for the liquid dose to be evacuated from the BFS ampoule.
[0033] Referring to FIG. 5, an outer surface of the shuttle 305 rides on ribs on an internal surface of the tip stem 205. The shuttle 305 provides a rigid body for the ribs on the internal surface of the actuator neck 125 to press against to propel the shuttle 305 forward towards the proximal end of the tip 115, rather than pushing directly onto the flexible BFS ampoule itself. The shuttle 305 may have internal support features (e.g., ribs, notches, or the like) (not shown) to support the BFS ampoule, in one example concentrically, so that the BFS ampoule may be punctured. The splayed lips on the proximal end of the shuttle 305 prevent the shuttle 305 from being inserted backwards into the tip stem 205. Additionally, the splayed lips 505 ensure that the shuttle 305 and the tip stem 205 will be in interference across tolerance ranges. The shuttle 305 also shields the dose containing BFS ampoule from sight, limiting light exposure, device tampering, or premature ampoule puncture from external objects.
[0034] Referring back to FIG. 3, the dip tube 310 is positioned within the cavity 345 of the tip stem 205. The dip tube 310, also shown in FIG. 7, includes a delivery channel 315 that extends from a proximal end to a distal end of the dip tube 310. The delivery channel 315 is in fluid communication with the nozzle channel 330, the nozzle 325, and the outlet orifice 335. In the embodiment of FIG. 3 , the dip tube 310 includes a puncture member 350 about the distal end of the dip tube 310. In the embodiment of FIG. 3, the puncture member 350 is an angled edge about the distal end of the dip tube 310. In other embodiments, the dip tube 310 may include more than one puncture member at the distal end, and the shape and/or
angle of the puncture member may vary. The puncture member 350 punctures the compound container 340 as the shuttle 305 is driven towards the nose cone 130 from the sealed state to the unsealed state by the ribs on the internal surface of the actuator neck 125. In this configuration, the dip tube punctures through the compound container 340 and seats inside the compound container 340 (e.g., near the base of the compound container 340). In one embodiment, the dip tube 310 may have external walls that taper such that the punctured hole in the compound container 340 created by the puncture member 350 is smaller than the diameter of the dip tube 310, thereby creating a water and gas-tight seal between the dip tube 310 and the compound container 340. The tapered walls may also increase the rigidity of the puncture member 350. A protruding ring feature 355 on the proximal end of the dip tube 310 provides a mating interface for mating with the nozzle channel 330. An interference fit between the protruding ring feature 355 of the dip tube 310 and the nozzle channel 330 may seal the components such that the delivery channel 315 and the nozzle channel 330 are in fluid communication.
[0035] The collar 320 is positioned about the proximal end of the dip tube 310 within the tip cone 130. The collar 320 is designed to puncture the compound container 340 to create a flow path between the propellant channel and the compound container 340 such that propellant released from the canister 110 flows into the punctured compound container 340. Referring also to FIG. 8, the collar 320 includes a central opening 805, one or more bypass openings 810, and one or more puncture members 815. The one or more puncture members 815 are on a bottom surface of the collar 320. The collar 320 is installed over the dip tube 310, where the central opening 805 mates with the protruding ring feature 355 of the dip tube 310 and forms a seal to hold the collar in place. The collar 320 is oriented such that the puncture members 815 are oriented towards the compound container 340. During installation of the tip 115 into the actuator neck 125, the compound container 340 is punctured first by the dip tube 310 and second by the collar 320. The collar 320 seats into the top of the compound container 340. The bypass openings 810 around the perimeter of the collar 320 introduce propellant into the compound container during device 100 actuation. Any dose displaced into the collar 320 during puncture of the compound container 340 is forced back into the compound container 340 by the propellant. In this manner, the dose and the propellant are mixed together in the container 340 and then evacuated through the dip tube 310 during device 100 actuation.
[0036] Referring back to FIG. 3, the nozzle 325 directs the spray of propellant and dose from the nozzle channel 330 and out the outlet orifice 335 such that the spray is targeted
towards the olfactory region of a user. The nozzle 325 may form a narrow plume. The nozzle 325 is positioned within the nozzle channel 330 of the tip cone 130. In the embodiment of FIG. 3, the nozzle 325 is at the proximal end of the tip cone 130, adjacent to the outlet orifice 335. Referring also to FIG. 9, the nozzle 325 may include one or more channels 905 that may be oriented parallel to a central axis of the nozzle 325 or tapered towards or away from the central axis. The nozzle channel 330 connecting the nozzle 325 and the dip tube 310 may serve as a displacement volume for the liquid dose during puncture of the compound container. The nozzle 325 forms a liquid and gas-tight seal around the outer diameter within the nozzle channel 330. During actuation, propellant evacuates liquid dose from the compound container 340, pushing it through the nozzle channel 330 and out the nozzle 325. In some embodiments, the type of nozzle 325 installed into the nozzle channel 330 may vary, which enables the device 100 to adapt to different formulation types or plume styles.
[0037] The actuator body 105, shown in FIGS. 1 and 10, couples the propellant canister 110, shown in FIGS. 1 and 11, to the tip 115. The propellant canister 110 seats and seals inside a large upright cavity of the actuator body 105. During use, the tip 115 is inserted into the neck 125 of the actuator body 105. Internal ribs (not shown) on the internal surface of the actuator neck 125 contact the compound container 340 and drive the compound container 340 towards the puncture members on the dip tube 310 and the collar 320. The actuator neck 125 seals to the tip 115 to pressurize the tip 115. In one example, clips near the end of the actuator neck 125 interface with the tip cone during use.
[0038] The propellant canister 110 provides the propulsion for the device. The canister 110 is inserted into the actuator body 105. During use, the canister 110 is depressed, releasing a metered volume of liquid propellant. As the propellant vaporizes and expands, the propellant travels through the propellant channel of the actuator body and into the tip stem 205 through the slots 210. Since the tip stem 205 is pressurized, the propellant forces the liquid dose out of the compound container 340 and out through the nozzle 325 and the outlet orifice 335. In one embodiment, the propellant fills the tip stem (e.g., traveling through the cavity 345, through the bypass openings 810, into the nose cone 130), such that the displaced air volume forces the liquid dose out of the compound container 340. In one embodiment, the propellant fills the tip stem 205 and then enters the compound container 340 through the punctured openings, where the propellant and compound mix together before exiting through the outlet orifice 335. The canister 110 may contain enough propellant for
multiple doses. Propellant type and volume may be selected by one of skill in the art based on performance data.
Additional Configuration Tnformation
[0039] The foregoing description of the embodiments of the disclosure has been presented for the purpose of illustration; it is not intended to be exhaustive or to limit the disclosure to the precise forms disclosed. Persons skilled in the relevant art can appreciate that many modifications and variations are possible in light of the above disclosure.
[0040] The language used in the specification has been principally selected for readability and instructional purposes, and it may not have been selected to delineate or circumscribe the inventive subject matter. It is therefore intended that the scope of the disclosure be limited not by this detailed description, but rather by any claims that issue on an application based hereon. Accordingly, the disclosure of the embodiments is intended to be illustrative, but not limiting, of the scope of the disclosure, which is set forth in the following claims.
Claims
1. A device for delivering a compound to an olfactory region of a nasal cavity comprising:
an actuator body comprising:
a propellant channel configured to be in fluid communication with a
canister containing a propellant;
a tip configured to removably couple to the actuator body, the tip comprising: a tip stem comprising a cavity and an opening such that the cavity is in fluid communication with the propellant channel, wherein the cavity is configured to receive a compound container containing the compound and wherein the compound container is configured to move between a sealed state and an unsealed state within the cavity;
a dip tube positioned within the cavity, the dip tube comprising a delivery channel that extends from a proximal end to a distal end of the dip tube;
one or more puncture members that are each configured to puncture the compound container when the compound container is in the unsealed state such that the punctured compound container is in fluid communication with the propellant channel and the delivery channel;
an outlet orifice in fluid communication with the delivery channel, such that propellant released from the canister travels through the propellant channel and into the cavity, through the plurality of openings and into the compound container, thereby contacting the compound and propelling the compound through the delivery channel and out the outlet orifice.
2. The device of claim 1, wherein at least one puncture member is disposed at the proximal end of the dip tube.
3. The device of claim 1, further comprising a collar that couples about a portion of the dip tube, wherein at least one puncture member is positioned on the collar.
4. The device of claim 3, wherein at least one puncture member is disposed at the proximal end of the dip tube, and the at least one puncture member is configured to puncture the compound container first and the at least one puncture member positioned on the collar is configured to puncture the compound container second when the compound container is in the unsealed state.
5. The device of claim 3, wherein the collar comprises one or more openings that are in fluid communication with the propellant channel and are configured to introduce released propellant into the compound container.
6. The device of claim 1, further comprising a tip cone configured to couple to the tip stem, wherein the tip cone is configured to align the device with a nostril of a user.
7. The device of claim 6, wherein the tip cone comprises a depth stop guard that is configured to indicate an amount of depth insertion into the nostril of the user.
8. The device of claim 1, further comprising a nozzle in fluid communication with the delivery channel and the outlet orifice, wherein the nozzle comprises one or more channels.
9. The device of claim 1, further comprising a sealing interface between the tip and the actuator body.
10. The device of claim 1, wherein the compound container is composed of a plastic film.
11. The device of claim 1, wherein the actuator body comprises a release button that, when actuated, is configured to decouple the tip from the actuator body.
12. The device of claim 1, wherein the release button is connected to one or more clip features that are configured to mate with one or more openings on the tip, thereby coupling the tip to the actuator body.
13. The device of claim 1, wherein the opening of the tip stem is configured to receive a reciprocal rib on an internal surface of the actuator body, and wherein the reciprocal rib is configured to move the compound container from the sealed state to the unsealed state within the cavity as the tip is inserted into the actuator body.
14. The device of claim 1, further comprising a shuttle configured to house the compound container, wherein the shuttle is inserted into the cavity.
15. The device of claim 14, wherein the shuttle is configured to provide a rigid body for moving between the sealed state and the unsealed state
16. The device of claim 14, wherein the shuttle comprises one or more splayed lips that are configured to indicate an orientation of the shuttle upon insertion into the cavity.
17. The device of claim 1, wherein the compound is a liquid.
ABSTRACT
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
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EP18881599.7A EP3713628A4 (en) | 2017-11-21 | 2018-11-21 | Intranasal device with dip tube |
JP2020528005A JP7191099B2 (en) | 2017-11-21 | 2018-11-21 | intranasal device with dip tube |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762589306P | 2017-11-21 | 2017-11-21 | |
US62/589,306 | 2017-11-21 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/US2018/062296 WO2019104205A1 (en) | 2017-11-21 | 2018-11-21 | Intranasal device with dip tube |
Country Status (4)
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US (1) | US11571532B2 (en) |
EP (1) | EP3713628A4 (en) |
JP (1) | JP7191099B2 (en) |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020142206A1 (en) | 2019-01-03 | 2020-07-09 | Impel Neuropharma, Inc. | Nasal drug delivery device |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20240009409A1 (en) * | 2020-09-01 | 2024-01-11 | Janssen Pharmaceutica Nv | Drug delivery devices with reusable components and disposable components |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6079634A (en) * | 1996-05-30 | 2000-06-27 | The Procter & Gamble Company | Electrostatic spraying |
US20040153033A1 (en) * | 2001-04-10 | 2004-08-05 | Paolo Mazzoni | Dispenser |
US20110057055A1 (en) * | 2009-09-07 | 2011-03-10 | Mk International Pty Ltd | Single dose nasal spray pump |
US20160058960A1 (en) * | 2013-04-04 | 2016-03-03 | The United State of America, as represented by the Secretary, Department of Health and Human Service | Nasal aerosol delivery system |
US20160101245A1 (en) | 2013-04-28 | 2016-04-14 | Impel Neuropharma Inc. | Medical Unit Dose Container |
WO2017044897A1 (en) | 2015-09-10 | 2017-03-16 | Impel Neuropharma Inc. | In-line nasal delivery device |
Family Cites Families (151)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB806284A (en) | 1955-11-14 | 1958-12-23 | Chi Ah Lai | A new or improved nasal inhaler |
US2933259A (en) | 1958-03-03 | 1960-04-19 | Jean F Raskin | Nozzle head |
US3425414A (en) | 1965-05-28 | 1969-02-04 | William J La Roche | Inhalant dispenser |
US3888253A (en) | 1972-08-04 | 1975-06-10 | Beecham Group Ltd | Device for administration of medicines |
FR2224175B1 (en) | 1973-04-04 | 1978-04-14 | Isf Spa | |
US3971377A (en) | 1974-06-10 | 1976-07-27 | Alza Corporation | Medicament dispensing process for inhalation therapy |
US3908654A (en) | 1974-08-02 | 1975-09-30 | Rit Rech Ind Therapeut | Dispensing package for a dry biological and a liquid diluent |
ZA758010B (en) | 1975-11-14 | 1977-08-31 | Syntex Inc | Nasal spray adapter |
US4095596A (en) | 1976-11-26 | 1978-06-20 | Smithkline Corporation | Nasal inhaler |
US4227522A (en) | 1978-09-05 | 1980-10-14 | Syntex Puerto Rico, Inc. | Inhalation device |
US4187985A (en) | 1978-12-08 | 1980-02-12 | The Continental Group, Inc. | Aerosol valve for barrier type packages |
BR8007911A (en) | 1979-12-06 | 1981-06-16 | Glaxo Group Ltd | PERFECTED INHALER |
US4412573A (en) | 1981-12-28 | 1983-11-01 | Baxter Travenol Laboratories, Inc. | Injection site |
WO1985002346A1 (en) | 1983-11-28 | 1985-06-06 | Vortran Corporation | Gas-powered nebulizer |
EP0162853A1 (en) | 1983-11-28 | 1985-12-04 | Vortran Corporation | Single inlet prepackaged inhaler |
WO1986001731A1 (en) | 1984-09-18 | 1986-03-27 | Vortran Corporation | All purpose nebulizer |
US4896832A (en) | 1987-09-07 | 1990-01-30 | Bespak Plc | Dispensing apparatus for metered quantities of pressurised fluid |
IT1228459B (en) | 1989-02-23 | 1991-06-19 | Phidea S R L | INHALER WITH REGULAR AND COMPLETE EMPTYING OF THE CAPSULE. |
US5624898A (en) | 1989-12-05 | 1997-04-29 | Ramsey Foundation | Method for administering neurologic agents to the brain |
NZ250988A (en) | 1990-06-14 | 1995-09-26 | Rhone Poulenc Rorer Ltd | Powder inhaler: swirling chamber with anti-static walls |
DE4038049C2 (en) | 1990-11-29 | 1994-12-01 | Anschuetz & Co Gmbh | Implantable infusion pump |
US5331954A (en) | 1990-12-21 | 1994-07-26 | Novo Nordisk A/S | Device for nasal delivery of liquid medications |
IT1249600B (en) | 1991-02-21 | 1995-03-09 | Elettro Plastica Spa | NASAL DISPENSER OF SPRAYED PHARMACEUTICAL SUBSTANCES |
US6681767B1 (en) | 1991-07-02 | 2004-01-27 | Nektar Therapeutics | Method and device for delivering aerosolized medicaments |
IT1250691B (en) | 1991-07-22 | 1995-04-21 | Giancarlo Santus | THERAPEUTIC COMPOSITIONS FOR INTRANASAL ADMINISTRATION INCLUDING KETOROLAC. |
GB9125699D0 (en) | 1991-12-03 | 1992-01-29 | Glaxo Group Ltd | Device |
GB9311892D0 (en) | 1993-06-09 | 1993-07-28 | Glaxo Wellcome Australia Ltd | Device |
US5349947A (en) | 1993-07-15 | 1994-09-27 | Newhouse Michael T | Dry powder inhaler and process that explosively discharges a dose of powder and gas from a soft plastic pillow |
US5516006A (en) | 1993-07-30 | 1996-05-14 | Meshberg; Philip | Nasal dispenser |
US5398850A (en) | 1993-08-06 | 1995-03-21 | River Medical, Inc. | Gas delivery apparatus for infusion |
IT1266794B1 (en) | 1993-11-09 | 1997-01-21 | Faustino Ballini | MICRONIZED SHOWER DEVICE FOR WASHING THE NASAL AND NEIGHBORING CAVITIES |
JP3911290B2 (en) | 1994-05-13 | 2007-05-09 | アラダイム コーポレーション | Anesthesia prescription with aerosol |
US5435282A (en) | 1994-05-19 | 1995-07-25 | Habley Medical Technology Corporation | Nebulizer |
JP3372105B2 (en) | 1994-05-26 | 2003-01-27 | 株式会社日立ユニシアオートモティブ | Inhalation type dispenser |
US5901703A (en) | 1995-02-06 | 1999-05-11 | Unisia Jecs Corporation | Medicine administering device for nasal cavities |
DE19518580A1 (en) | 1995-05-20 | 1996-11-21 | Thomas Ossinger | Electrically heated dip soldering crucible |
JPH08322934A (en) | 1995-05-29 | 1996-12-10 | Unisia Jecs Corp | Dosing device for nasal cavity |
DE19523516C1 (en) | 1995-06-30 | 1996-10-31 | Asta Medica Ag | Inhaler for administering medication from blister packs |
US5823183A (en) | 1995-08-02 | 1998-10-20 | Innovative Devices | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament |
GB9516984D0 (en) | 1995-08-18 | 1995-10-18 | Pharmasol Ltd | Spray applicator |
IE77523B1 (en) | 1995-09-11 | 1997-12-17 | Elan Med Tech | Medicament delivery device |
US5711488A (en) | 1995-10-13 | 1998-01-27 | The Procter & Gamble Company | High pressure swirl atomizer |
US6678553B2 (en) | 1995-11-21 | 2004-01-13 | Intraabrain International Nv | Device for enhanced delivery of biologically active substances and compounds in an organism |
US5797390A (en) | 1996-03-06 | 1998-08-25 | Mcsoley; Thomas E. | Nasal inhaler having a directed spray pattern |
AUPN976496A0 (en) | 1996-05-10 | 1996-05-30 | Glaxo Wellcome Australia Ltd | Unit dose dispensing device |
US6595202B2 (en) | 1996-05-13 | 2003-07-22 | Universidad De Sevilla | Device and method for creating aerosols for drug delivery |
DE19622124A1 (en) | 1996-06-01 | 1997-12-04 | Alfred Von Schuckmann | Device for applying liquids |
WO1997048496A1 (en) | 1996-06-21 | 1997-12-24 | Hughes Technology Group L.L.C. | Micro-atomizing device |
US5906198A (en) | 1996-07-16 | 1999-05-25 | Flickinger; William J. | Nasal nebulizer |
US6410046B1 (en) | 1996-11-19 | 2002-06-25 | Intrabrain International Nv | Administering pharmaceuticals to the mammalian central nervous system |
US7033598B2 (en) | 1996-11-19 | 2006-04-25 | Intrabrain International N.V. | Methods and apparatus for enhanced and controlled delivery of a biologically active agent into the central nervous system of a mammal |
DE19704849B4 (en) | 1997-02-08 | 2011-02-17 | Ing. Erich Pfeiffer Gmbh | Discharge device for media |
IS4516A (en) | 1997-07-01 | 1999-01-02 | Gizurarson Sveinbjörn | New pharmaceutical form |
US7799337B2 (en) | 1997-07-21 | 2010-09-21 | Levin Bruce H | Method for directed intranasal administration of a composition |
US6491940B1 (en) | 1999-01-27 | 2002-12-10 | Bruce H. Levin | Apparatus for administering composition for inhibiting cerebral neurovascular disorders and muscular headaches |
GB9719775D0 (en) | 1997-09-18 | 1997-11-19 | Glaxo Group Ltd | Device |
US5954696A (en) | 1997-12-15 | 1999-09-21 | B. Braun Medical, Inc. | Pressure infusion pump |
US7335186B2 (en) | 1998-03-13 | 2008-02-26 | Alexander George Brian O'Neil | Patient controlled drug delivery device |
US6113078A (en) | 1998-03-18 | 2000-09-05 | Lytesyde, Llc | Fluid processing method |
US6062213A (en) | 1998-06-16 | 2000-05-16 | Fuisz Technologies Ltd. | Single unit dose inhalation therapy device |
ES2234266T3 (en) | 1998-07-24 | 2005-06-16 | Jago Research Ag | MEDICAL FORMULATIONS FOR AEROSOLS. |
FR2782024B1 (en) | 1998-08-04 | 2000-10-13 | Valois Sa | DISPENSING HEAD AND DEVICE FOR DISPENSING A FLUID PRODUCT COMPRISING SUCH A HEAD |
GB2345010B (en) | 1998-12-17 | 2002-12-31 | Electrosols Ltd | A delivery device |
US6294153B1 (en) | 1998-12-21 | 2001-09-25 | Generex Pharmaceuticals, Inc. | Aerosol pharmaceutical formulation for pulmonary and nasal delivery |
US6248363B1 (en) | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
GB0121568D0 (en) | 2001-09-06 | 2001-10-24 | Optinose As | Nasal delivery device |
GB0114272D0 (en) | 2001-06-12 | 2001-08-01 | Optinose As | Nasal delivery device |
EP3124067A3 (en) | 1999-03-03 | 2017-05-24 | Optinose AS | Nasal delivery device |
CO5241299A1 (en) | 1999-03-17 | 2003-01-31 | Emsar Inc | APPLIANCE AND METHOD TO ADMINISTER A MEDICINAL SPRAY |
CA2368587A1 (en) | 1999-03-26 | 2000-10-05 | John R. Plachetka | High potency dihydroergotamine compositions |
DE19944209A1 (en) | 1999-09-15 | 2001-03-22 | Pfeiffer Erich Gmbh & Co Kg | Dispenser for possibly atomizing the discharge of a medium, in particular a liquid, from a container |
DE60007593T2 (en) * | 1999-10-14 | 2004-11-11 | Becton, Dickinson And Co. | Nasal delivery device with atomizing nozzle |
US6382204B1 (en) | 1999-10-14 | 2002-05-07 | Becton Dickinson And Company | Drug delivery system including holder and drug container |
US6367471B1 (en) | 1999-11-01 | 2002-04-09 | Sheffield Pharmaceuticals, Inc. | Internal vortex mechanism for inhaler device |
US6810872B1 (en) | 1999-12-10 | 2004-11-02 | Unisia Jecs Corporation | Inhalant medicator |
US6302101B1 (en) | 1999-12-14 | 2001-10-16 | Daniel Py | System and method for application of medicament into the nasal passage |
US6734162B2 (en) | 2000-01-24 | 2004-05-11 | Minimed Inc. | Mixed buffer system for stabilizing polypeptide formulations |
US6585957B1 (en) | 2000-01-25 | 2003-07-01 | Aeropharm Technology Incorporated | Medicinal aerosol formulation |
US6540983B1 (en) | 2000-01-25 | 2003-04-01 | Aeropharm Technology Incorporated | Medical aerosol formulation |
US6644305B2 (en) | 2000-04-14 | 2003-11-11 | Trudell Medical International | Nasal inhaler |
GB0015309D0 (en) | 2000-06-21 | 2000-08-16 | Djupesland Per G | Apparatus |
IT1317998B1 (en) | 2000-06-26 | 2003-07-21 | Medical Internat Licensing N V | DISPENSING VALVE FOR NASAL SPRAY. |
IT1318646B1 (en) | 2000-07-26 | 2003-08-27 | Medical Internat Licensing N V | NOZZLE PR ADMINISTRATIONS AND NASAL WASHES. |
DE20122843U1 (en) | 2000-07-31 | 2008-06-26 | Nycomed Danmark Aps | Fentanyl composition for nasal application |
US6596740B2 (en) | 2000-10-24 | 2003-07-22 | Richard L. Jones | Nicotine mucosal spray |
US7850663B2 (en) * | 2001-01-12 | 2010-12-14 | Becton, Dickinson And Company | Medicament microdevice delivery system, cartridge and method of use |
US6644309B2 (en) | 2001-01-12 | 2003-11-11 | Becton, Dickinson And Company | Medicament respiratory delivery device and method |
ZA200306564B (en) | 2001-02-26 | 2004-10-15 | Optinose As | Nasal devices. |
GB0109001D0 (en) | 2001-04-10 | 2001-05-30 | Glaxo Group Ltd | Dispenser |
CA2446904A1 (en) | 2001-05-24 | 2003-04-03 | Alexza Molecular Delivery Corporation | Delivery of drug esters through an inhalation route |
EP1279404A1 (en) | 2001-07-26 | 2003-01-29 | Istituto Superiore di Sanità | Use of HIV-1 tat, fragments or derivatives thereof, to target or to activate antigen-presenting cells, to deliver cargo molecules for vaccination or to treat other diseases |
AU2002340083A1 (en) | 2001-09-28 | 2003-04-07 | Kurve Technology, Inc | Nasal nebulizer |
GB2380410B (en) | 2001-10-05 | 2003-11-19 | Alchemy Healthcare Ltd | Apparatus for the nasal or oral delivery of a medicament |
US7021561B2 (en) | 2001-12-18 | 2006-04-04 | Becton, Dickinson And Company | Spray device and method |
GB0204829D0 (en) | 2002-03-01 | 2002-04-17 | Glaxo Group Ltd | A fluid dispensing device |
US7666876B2 (en) | 2002-03-19 | 2010-02-23 | Vernalis (R&D) Limited | Buprenorphine formulations for intranasal delivery |
GB0207422D0 (en) | 2002-03-28 | 2002-05-08 | Optinose As | Nasal devices |
GB0209494D0 (en) | 2002-04-25 | 2002-06-05 | Optinose As | Nasal devices |
WO2003093299A2 (en) | 2002-05-06 | 2003-11-13 | Thomas Jefferson University | Insulin-associated peptides with effects on cerebral health |
WO2003099359A1 (en) | 2002-05-09 | 2003-12-04 | Kurve Technology, Inc. | Particle dispersion chamber for nasal nebulizer |
US7220457B2 (en) | 2002-06-06 | 2007-05-22 | Anderson Steven R | Air atomizing assembly and method and system of applying an air atomized material |
GB0215270D0 (en) | 2002-07-02 | 2002-08-14 | Optinose As | Nasal devices |
GB0215904D0 (en) | 2002-07-09 | 2002-08-21 | Team Holdings Uk Ltd | Drug delivery system and method |
GB0217198D0 (en) | 2002-07-25 | 2002-09-04 | Glaxo Group Ltd | Medicament dispenser |
GB0309354D0 (en) | 2003-04-24 | 2003-06-04 | Glaxo Group Ltd | Nozzle for a nasal inhaler |
DE10321902A1 (en) | 2003-05-06 | 2004-12-09 | Ing. Erich Pfeiffer Gmbh | Discharge device for at least one medium |
GB0319119D0 (en) | 2003-08-14 | 2003-09-17 | Optinose As | Delivery devices |
GB0320171D0 (en) | 2003-08-28 | 2003-10-01 | Optinose As | Delivery devices |
US8001963B2 (en) | 2003-09-05 | 2011-08-23 | Kurve Technology, Inc. | Integrated nebulizer and particle dispersion chamber for nasal delivery of medicament to deep nasal cavity and paranasal sinuses |
US20070172517A1 (en) | 2003-09-17 | 2007-07-26 | Ben-Sasson Shmuel A | Compositions capable of facilitation penetration across a biological barrier |
GB0322284D0 (en) | 2003-09-23 | 2003-10-22 | Glaxo Group Ltd | Medicament dispenser |
US7832394B2 (en) | 2004-12-22 | 2010-11-16 | Schechter Alan M | Apparatus for dispensing pressurized contents |
GB0503738D0 (en) | 2005-02-23 | 2005-03-30 | Optinose As | Powder delivery devices |
NZ562064A (en) | 2005-04-01 | 2011-03-31 | Intezyne Technologies Inc | Polymeric micelles for drug delivery |
GB0515592D0 (en) | 2005-07-28 | 2005-09-07 | Glaxo Group Ltd | Nozzle for a nasal inhaler |
WO2007035913A2 (en) | 2005-09-21 | 2007-03-29 | Kurve Technology, Inc. | Medicament delivery control, monitoring, and reporting system and method |
MX2008006204A (en) | 2005-11-11 | 2008-10-17 | Aurogen Inc | Method for treating disease or disorder of adult central nervous system associated with tissue shrinkage or atrophy by administration of insulin. |
JP2009517184A (en) | 2005-11-29 | 2009-04-30 | アルザ・コーポレーシヨン | Nasal delivery device for delivering substances to olfactory sites |
US20070202051A1 (en) | 2006-02-10 | 2007-08-30 | Pari Gmbh | Aerosols for sinunasal drug delivery |
EP1988953B1 (en) | 2006-02-14 | 2017-07-19 | Optinose AS | Delivery device |
GB0604444D0 (en) | 2006-03-06 | 2006-04-12 | Optinose As | Nasal devices |
GB0605799D0 (en) | 2006-03-23 | 2006-05-03 | Optinose As | Nasal delivery devices |
US7841338B2 (en) | 2006-04-13 | 2010-11-30 | Boehringer Ingelheim International Gmbh | Dispensing device |
GB2440316A (en) | 2006-07-25 | 2008-01-30 | Optinose As | Nasal inhaler with scrubber |
CA2698137A1 (en) | 2006-08-30 | 2008-03-06 | Kurve Technology, Inc. | Aerosol generating and delivery device |
FR2908753B1 (en) | 2006-11-16 | 2011-11-11 | Becton Dickinson France | DEVICE FOR AUTOMATICALLY DELIVERING SUCCESSIVE PRODUCT DOSES |
WO2008067254A2 (en) | 2006-11-27 | 2008-06-05 | Abbott Respiratory Llc | Nasal drug delivery device and method |
GB0623728D0 (en) | 2006-11-28 | 2007-01-10 | Optinose As | Delivery devices |
GB0623732D0 (en) | 2006-11-28 | 2007-01-10 | Optinose As | Powder delivery devices |
PL2425820T3 (en) | 2007-02-11 | 2015-08-31 | Map Pharmaceuticals Inc | Method of therapeutic administration of dhe to enable rapid relief of migraine while minimizing side effect profile |
GB2448193A (en) | 2007-04-05 | 2008-10-08 | Optinose As | Nasal delivery device |
US8530463B2 (en) | 2007-05-07 | 2013-09-10 | Hale Biopharma Ventures Llc | Multimodal particulate formulations |
JP2011504163A (en) | 2007-06-08 | 2011-02-03 | ヘルスパートナーズ リサーチ ファウンデーション | Pharmaceutical compositions and methods for enhancing targeting of therapeutic compounds to the central nervous system |
GB0719299D0 (en) | 2007-10-03 | 2007-11-14 | Optinose As | Nasal delivery devices |
US20110053859A1 (en) | 2007-10-10 | 2011-03-03 | The U. S. Government Respresented by the Department of Veterans Affairs | Methods to reduce the effects of sleep deprivation |
CA2713762C (en) | 2008-02-07 | 2016-10-18 | University Of Washington | Circumferential aerosol device |
CA2715302A1 (en) | 2008-02-15 | 2009-08-20 | Timothy Sean Immel | Aerosol therapy device with high frequency delivery |
US8517026B2 (en) | 2008-02-25 | 2013-08-27 | Adva Beck Amon | Nasal inserts |
NO329804B1 (en) | 2009-02-09 | 2010-12-20 | Fmc Kongsberg Subsea As | Link for use in a riser, riser with such a link and method for increasing the operating window of a riser |
JP2012526726A (en) | 2009-05-15 | 2012-11-01 | 株式会社新日本科学 | Intranasal pharmaceutical composition with improved pharmacokinetics |
US8839790B2 (en) | 2009-07-29 | 2014-09-23 | Adva Beck Arnon | Nasal inserts |
US8925544B2 (en) | 2009-12-08 | 2015-01-06 | Medinvent, Llc | Portable nebulizer device |
CA2820554A1 (en) | 2010-11-29 | 2012-06-07 | Sanofi-Aventis Deutschland Gmbh | Medicated module for an inhaler |
RU2618084C2 (en) | 2011-05-09 | 2017-05-02 | Импел Ньюрофарма Инк. | Tips for nasal drug delivery |
WO2012174481A1 (en) | 2011-06-15 | 2012-12-20 | Nerve Access, Inc. | Pharmaceutical compositions for intranasal administration for the treatment of neurodegenerative disorders |
DE102012201178B3 (en) | 2012-01-27 | 2013-02-14 | Aptar Radolfzell Gmbh | Nozzle unit and dispenser with such |
AU2013305569A1 (en) | 2012-08-24 | 2015-02-19 | Vr1, Inc. | Composition for the treatment of migraine headaches |
DE102013100473A1 (en) | 2013-01-17 | 2014-07-17 | Seho Systemtechnik Gmbh | Method and device for cleaning a soldering nozzle |
ES2904570T3 (en) | 2013-09-24 | 2022-04-05 | Satsuma Pharmaceuticals Inc | Intranasal DHE formulation for the treatment of headache |
US10039321B2 (en) * | 2013-11-12 | 2018-08-07 | Vmr Products Llc | Vaporizer |
US9603905B2 (en) | 2014-03-13 | 2017-03-28 | The Research Foundation For Mental Hygiene, Inc | Intranasal insulin administration for the minimization of anesthesia-induced memory loss |
-
2018
- 2018-11-21 JP JP2020528005A patent/JP7191099B2/en active Active
- 2018-11-21 US US16/198,403 patent/US11571532B2/en active Active
- 2018-11-21 EP EP18881599.7A patent/EP3713628A4/en active Pending
- 2018-11-21 WO PCT/US2018/062296 patent/WO2019104205A1/en unknown
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6079634A (en) * | 1996-05-30 | 2000-06-27 | The Procter & Gamble Company | Electrostatic spraying |
US20040153033A1 (en) * | 2001-04-10 | 2004-08-05 | Paolo Mazzoni | Dispenser |
US20110057055A1 (en) * | 2009-09-07 | 2011-03-10 | Mk International Pty Ltd | Single dose nasal spray pump |
US20160058960A1 (en) * | 2013-04-04 | 2016-03-03 | The United State of America, as represented by the Secretary, Department of Health and Human Service | Nasal aerosol delivery system |
US20160101245A1 (en) | 2013-04-28 | 2016-04-14 | Impel Neuropharma Inc. | Medical Unit Dose Container |
WO2017044897A1 (en) | 2015-09-10 | 2017-03-16 | Impel Neuropharma Inc. | In-line nasal delivery device |
Non-Patent Citations (1)
Title |
---|
See also references of EP3713628A4 |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020142206A1 (en) | 2019-01-03 | 2020-07-09 | Impel Neuropharma, Inc. | Nasal drug delivery device |
EP3906017A4 (en) * | 2019-01-03 | 2022-12-28 | Impel Pharmaceuticals Inc. | Nasal drug delivery device |
AU2019418744B2 (en) * | 2019-01-03 | 2023-08-03 | Impel Pharmaceuticals Inc. | Nasal drug delivery device |
US11759585B2 (en) | 2019-01-03 | 2023-09-19 | Impel Pharmaceuticals Inc. | Nasal drug delivery device with detachable nozzle |
Also Published As
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US11571532B2 (en) | 2023-02-07 |
EP3713628A1 (en) | 2020-09-30 |
JP2021503989A (en) | 2021-02-15 |
EP3713628A4 (en) | 2021-08-18 |
US20190151579A1 (en) | 2019-05-23 |
JP7191099B2 (en) | 2022-12-16 |
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