WO2017128610A1 - 一种超干雾发生器 - Google Patents

一种超干雾发生器 Download PDF

Info

Publication number
WO2017128610A1
WO2017128610A1 PCT/CN2016/087405 CN2016087405W WO2017128610A1 WO 2017128610 A1 WO2017128610 A1 WO 2017128610A1 CN 2016087405 W CN2016087405 W CN 2016087405W WO 2017128610 A1 WO2017128610 A1 WO 2017128610A1
Authority
WO
WIPO (PCT)
Prior art keywords
ultra
liquid storage
mist generator
storage device
dry
Prior art date
Application number
PCT/CN2016/087405
Other languages
English (en)
French (fr)
Inventor
刘万忠
别明仿
张超
Original Assignee
湖北荷普药业股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 湖北荷普药业股份有限公司 filed Critical 湖北荷普药业股份有限公司
Priority to EP16820143.2A priority Critical patent/EP3238748A4/en
Priority to US15/315,693 priority patent/US10188765B2/en
Publication of WO2017128610A1 publication Critical patent/WO2017128610A1/zh

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/22—Phase substances, e.g. smokes, aerosols or sprayed or atomised substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/26—Accessories or devices or components used for biocidal treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L9/00—Disinfection, sterilisation or deodorisation of air
    • A61L9/14—Disinfection, sterilisation or deodorisation of air using sprayed or atomised substances including air-liquid contact processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/10—Apparatus features
    • A61L2202/15—Biocide distribution means, e.g. nozzles, pumps, manifolds, fans, baffles, sprayers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/10—Apparatus features
    • A61L2202/16—Mobile applications, e.g. portable devices, trailers, devices mounted on vehicles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2209/00—Aspects relating to disinfection, sterilisation or deodorisation of air
    • A61L2209/10—Apparatus features
    • A61L2209/11—Apparatus for controlling air treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2209/00—Aspects relating to disinfection, sterilisation or deodorisation of air
    • A61L2209/10—Apparatus features
    • A61L2209/13—Dispensing or storing means for active compounds
    • A61L2209/134—Distributing means, e.g. baffles, valves, manifolds, nozzles

Definitions

  • the invention relates to the field of sanitary disinfection, in particular to an ultra dry mist generator.
  • Microorganisms are widely found in nature. When the environment is suitable, microorganisms can grow and reproduce rapidly, causing pollution. Therefore, in some special environments, disinfection and sterilization are required.
  • the current disinfection method either has a poor disinfection effect, or is highly toxic or has a long sterilization time.
  • An ultra-dry mist generator comprising: a liquid storage device, an atomization device, a fan and a dry separation device having an opening at the top, the dry separation device being disposed above the liquid storage device And the drying and separating device is in communication with the liquid storage device, the atomizing device is located outside the liquid storage device, and the two ends of the atomizing device are respectively connected to the fan and the drying and separating device, and The atomizing device is also in communication with the liquid storage device, and the fan blows the liquid entering the inside of the atomizing device to the inside of the drying separation device.
  • said dry separation apparatus comprises at least two communicating cavity structures, the bottom of said dry separation apparatus being coupled to the top of said liquid storage means and in communication with the interior of said liquid storage means.
  • said dry separation apparatus comprises a first cavity structure, a second cavity structure and a third cavity structure in communication from bottom to top, said first cavity structure, said second cavity structure and
  • the liquid storage device has a unitary structure, and the second cavity structure is movably connected to the third cavity structure, and the opening of the third cavity structure is provided at the top.
  • the atomizing device is an atomizing nozzle, and the fan is a high speed hot air motor.
  • the inlet of the atomizing nozzle communicates with the air outlet of the high speed hot air motor, and the outlet of the atomizing nozzle communicates with the interior of the first cavity structure.
  • the bottom of the liquid storage device is provided with a through hole, and the through hole communicates with the inside of the atomizing nozzle through a pipe, and the liquid inside the liquid storage device enters the inside of the atomizing nozzle through the through hole and the pipe.
  • the ultra-dry mist generator further includes a casing, and the liquid storage device, the atomizing device, the fan and the drying and separating device are both disposed inside the casing, and the casing is provided with a perforation.
  • the air inlet of the high speed hot air motor communicates with the outside through the through hole.
  • the ultra-dry mist generator further includes a first bracket and a second bracket, the first bracket being disposed between the bottom plate of the outer casing and the fan for supporting the fan, the first A second bracket is disposed between the fan and the third cavity structure for supporting the third cavity structure.
  • the ultra dry mist generator further includes a circuit controller, the circuit controller being coupled to the fan.
  • the ultra dry mist generator further includes a roller, and a bottom of the outer casing is provided with a plurality of rollers.
  • the disinfecting liquid enters the atomizing device from the liquid storage device, and the liquid is atomized into small particles by the atomizing device, and is dried by the drying device after being driven by the fan, and discharged to the space to be disinfected for disinfection operation;
  • Small particles of disinfecting liquid after atomization the particle size is smaller, it is closer to the size of bacteria, can be suspended in the air for a long time, and fully contact with bacteria in the air to achieve sterilization purposes, and to disinfect the objects in the space
  • the corrosion is small, convenient and safe; in addition, the invention has a simple structure and a low cost.
  • FIG. 1 is a schematic structural view of an ultra dry mist generator according to an embodiment of the present invention.
  • the present invention provides an ultra-dry mist generator comprising: a liquid storage device 1, an atomizing device 3, a fan 2, and a drying separation device 4 having an opening 44 at the top thereof.
  • the dry separation device 4 is disposed above the liquid storage device 1, and the dry separation device 4 is in communication with the liquid storage device 1, the atomization device 3 is located outside the liquid storage device 1, The two ends of the atomizing device 3 are respectively communicated with the fan 2 and the drying and separating device 4, and the atomizing device 3 is also in communication with the liquid storage device 1, and the fan 2 blows the liquid entering the inside of the atomizing device 3 to The inside of the separation device 4 is dried.
  • the drying separation device 4 is in communication with the liquid storage device 1, and a disinfecting liquid suitable for the bacteria to be disinfected is disposed and stored in the liquid storage device 1.
  • a disinfecting liquid suitable for the bacteria to be disinfected is disposed and stored in the liquid storage device 1.
  • the liquid for disinfection enters the mist from the liquid storage device 1.
  • the chemical device 3 atomizes the liquid into small liquid particles by the atomizing device 3, and under the blowing of the fan 2, the small liquid particles enter the drying separation device 4, move upward along the inner wall of the drying separation device 4, and finally separate from the drying.
  • the opening 44 at the top of the device 4 is discharged to the space to be disinfected, and the larger liquid particles which are not dried are condensed by the inner wall of the drying separation device 4 into a solution reflux and then enter the storage device; the disinfecting liquid can also be added to the storage through the opening 44.
  • the liquid device 1, that is, the opening 44 can serve as a liquid inlet;
  • the blowing of the fan 2 causes the small liquid particles to be continuously dried and separated in the drying and separating device 4, the particle diameter is further reduced, and the water content is further reduced, and most of the achievable Less than 1 ⁇ m, or even partially reach 0.1 ⁇ m, small liquid particles can be suspended in the air for a long time and fully contact with bacteria in the air for sterilization purposes; and the water content is further reduced, which can greatly reduce the corrosion of equipment in the space to be disinfected; Moreover, the experiment shows that the smaller the concentration of the liquid for disinfection, the smaller the particle size of the atomized into liquid small particles.
  • the use of a lower concentration of the disinfecting liquid can greatly reduce the corrosion of objects in the disinfection space, and also improves the corrosion.
  • the efficiency of sterilization and sterilization is convenient and safe; in addition, the invention has simple structure and low cost, and is particularly suitable for disinfection and sterilization in a confined space, such as a GMP purification workshop, a hospital operating room, an ICU ward, a freeze dryer, Disinfection and sterilization of transfer windows and biological safety cabinets. It is compatible with active hydrogen peroxide, has the advantages of no residue after sterilization, no pollution, etc. It is an ideal disinfection and sterilization equipment that can replace formaldehyde.
  • the dry separation device 4 comprises at least two communicating cavity structures, the bottom of the dry separation device 4 is connected to the top of the liquid storage device 1, and the liquid storage The interior of the device 1 is in communication.
  • the drying and separating device 4 includes a first cavity structure 41, a second cavity structure 42 and a third cavity structure 43 connected in sequence from bottom to top, the first cavity structure 41, the second cavity structure 42 and the liquid storage device 1
  • the second cavity structure 42 is movably connected to the third cavity structure 43
  • the opening 44 is disposed at the top of the third cavity structure 43 .
  • the drying separation device 4 comprises at least two communicating cavity structures, that is, at least two stages of separators, and the cavity of the cavity structure may have a shape of a circle, a square or any other shape, and each cavity structure may pass between The pipe or the perforated partition is connected, but it must be ensured that the added disinfecting liquid can completely flow into the liquid storage device 1 without significant residue, and at the same time, it is ensured that the disinfecting liquid which has passed through the inner wall of the drying separation device 4 is also completely recirculated.
  • the upper portion of the final stage separator (the third cavity structure 43 in this embodiment) is provided with an opening 44 as a dry mist particle of the disinfecting liquid after drying and separation (particle size is less than 1 ⁇ m)
  • the spray outlet is also used as a filling port for the disinfecting liquid; the first cavity structure 41, the second cavity structure 42 and the liquid storage device 1 have an integrated structure to prevent leakage of liquid leakage.
  • the atomizing device 3 is an atomizing nozzle, and the fan 2 is a high speed hot air motor.
  • an inlet of the atomizing nozzle communicates with an air outlet of the high-speed hot air motor, and an outlet of the atomizing nozzle communicates with an interior of the first cavity structure 41 .
  • the high-speed hot air motor blows hot air, and when the atomized liquid small particles are blown into the dry separation device 4 and moved upward along the inner wall, the liquid small particles are easily dehydrated, and the water content is Further reducing, while achieving a smaller particle size and sufficient contact with the bacteria in the air, it also further reduces the corrosion of the equipment in the space to be disinfected;
  • the air inlet of the high-speed hot air motor is equipped with an interface to facilitate the connection of the hose and the sterilization to be disinfected Confined space such as freezing
  • the dryer, the transfer window and the biological safety cabinet are connected, and the air outlet of the high-speed hot air motor is also provided with an interface, which is convenient to communicate with the inlet of the atomizing nozzle through the pipeline;
  • the atomizing nozzle can be a pneumatic atomizing nozzle, and can be driven by high-speed hot air
  • the atomizing nozzle is preferred to the two-fluid atomizing nozzle (pneumatic nozzle). On the one hand, it is necessary to ensure that a negative pressure is formed at the outlet of the disinfecting liquid, so that the disinfecting liquid is conveniently sucked into the atomizing nozzle from the liquid storage device 1, and on the other hand, a larger one is to be ensured.
  • the atomization area so that the small particles of the disinfectant sprayed from the atomizing nozzle are diffused and dried in a large area in the first cavity structure 41, thereby forming smaller disinfectant particles, and a part of the large particles which are not dried.
  • Entering the second or third cavity structure 43 is once again dried to form smaller particles, and another portion of the larger particles that are not dried is condensed into a liquid refluxing into the liquid storage device 1 for re-atomization, so that the reciprocation is achieved.
  • the size of the particles is completely dry and separated.
  • the bottom of the liquid storage device 1 is provided with a through hole 11 , and the through hole 11 communicates with the inside of the atomizing nozzle through a pipe, and the liquid inside the liquid storage device 1 passes through the through hole 11 and the pipe. Entering the inside of the atomizing nozzle.
  • the liquid storage device 1 adopts a liquid storage tank, which is preferably round or square, and has a through hole 11 at the bottom, and is connected with the atomizing nozzle through a pipe, and can also be equipped with the liquid storage device 1
  • the position meter is used to observe and calculate the size of the spray volume and whether there is any residual after the atomized disinfectant liquid is atomized.
  • the ultra-dry mist generator further includes a casing 7 , and the liquid storage device 1 , the atomizing device 3 , the fan 2 and the drying and separating device 4 are both disposed inside the casing 7 .
  • the outer casing 7 is provided with a through hole 71 through which the air inlet of the high speed hot air motor passes The outside world is connected.
  • the arrangement of the outer casing 7 can fix various components in the embodiment of the invention, and the arrangement of the perforations 71 can provide a wind source for the high speed hot air motor.
  • the ultra dry mist generator further includes a first bracket 6 and a second bracket 5 disposed between the bottom plate inside the outer casing 7 and the fan 2 For supporting the fan 2, the second bracket 5 is disposed between the fan 2 and the third cavity structure 43 for supporting the third cavity structure 43.
  • the ultra dry mist generator further includes a circuit controller, and the circuit controller is connected to the fan 2.
  • the ultra-dry mist generator further includes a roller 72, and a bottom of the outer casing 7 is provided with a plurality of rollers 72.
  • the particle size after atomization was measured. Since the atomized particles produced by the present invention are very dry and most of the particle diameter is less than 1 micrometer, the particle size is not suitable for measurement by a conventional laser particle size tester (Note: This technique is only suitable for measuring particle diameters larger than 1 micron. Particles), so we used a special dust particle detector to measure its particle size and distribution.
  • a purification workshop in the GMP factory of the pharmaceutical company the workshop is 2.8m high, 4.4m wide and 6.5m long, and the total volume of space is about 80m 3 .
  • the test results for the number of particles of different sizes are shown in Table 1.
  • the statistical results are shown in Table 2. It can be seen from Table 1 and Table 2 that the particle size of the particles produced by the ultra-dry mist generator of the present invention after atomization of the 6% hydrogen peroxide disinfectant is less than 1 ⁇ m (more than 60%), mainly distributed in 0.3- Between 0.5 ⁇ m. As the measurement distance increases, the number of small particles increases, and the number of large particles decreases. However, when the measurement distance is greater than 0.5 m, the measurement results show no significant change. This indicates that the used hydrogen peroxide disinfectant is a true dry mist after being atomized and dried by the dry mist device of the present invention.
  • the concentration of the hydrogen peroxide disinfectant used is less than 10%, the particles (less than 10 ⁇ m) after the initial atomization by the technique of the present invention are inevitably turned into smaller particles after being dried and separated (at least 90% concentrated, That is less than 1 ⁇ m).
  • the atomized particles contain a large amount of water (more than 90%), even if the particle size after atomization is less than 5 ⁇ m, the atomization outlet is too close to the object to be disinfected (less than 1 m). ), the object to be sterilized is also wetted to cause severe corrosion.
  • Orpheum dry fog sterilization equipment (OXYPHARM company, model OXY-25000); biological indicator (Bacillus stearothermophilus spores, spore amount 10 6 ), with supporting chemical indicator and TSB liquid Medium (produced by Beijing Jinsihuan Technology Co., Ltd.), the same below; 6% Active hydrogen peroxide disinfectant (sporeicide, standard Q/HHP 001-2015), ibid.; 3% Active hydrogen peroxide disinfectant, from 6% The active hydrogen peroxide disinfectant is diluted with an equal volume of purified water, the same below.
  • a purification workshop in the GMP factory of the pharmaceutical company the workshop is 2.8m high, 4.4m wide and 6.5m long, and the total volume of space is about 80m 3 .
  • the 80m 3 GMP workshop was disinfected by the ultra-dry mist generator and the Orpheum dry mist sterilization equipment of the present invention.
  • Bacterial test According to the size of the workshop space, it is sprayed at 5ml/m 3 or 400ml.
  • the active hydrogen peroxide disinfectant is spray sterilized.
  • both devices are placed in the middle of the workshop.
  • Five biological indicators are placed in the middle of the workshop (No. 3) and four different corners (the two corner points in front of the equipment spray head are numbered 1 and 2, respectively.
  • the two points in the rear corner are numbered 4 and 5 respectively.
  • the height of all biological indicators is 1m from the ground.
  • thermophilic adipose spore culture solution was placed in a constant temperature incubator according to the instruction manual of the purchased biological indicator, and cultured in a 50 ° C - 55 ° C incubator for 48 hours. At the same time, one tablet of the same batch of biological indicator was taken as a positive control. After 48 hours of culture, if the culture solution became cloudy, the color was changed from purple to yellow, and it was judged to be positive; if the culture solution was clarified, the color was not changed to be negative; the culture was continued until the 7th day, and the growth was still acceptable.
  • Table 3 shows that, when the spray amount 5ml / m 3, active hydrogen peroxide disinfectant concentration of 6%, two kinds of sterilization devices can meet the requirements of sterilization, i.e., 106 can kill the spores;
  • the spray amount is 5ml/m 3 and the concentration of the active hydrogen peroxide disinfectant is reduced to 3%, the Orpheum dry mist sterilization equipment does not meet the sterilization requirements, and the ultra dry mist generator of the present invention Sterilization requirements can still be achieved.
  • the ultra-dry mist generator of the invention is more effective in sterilizing and sterilizing in the GMP workshop, and has better sterilization effect and better sterilization effect, and thus is superior to the existing products.
  • the front box volume is 3.3m 3
  • the back box volume is 3.8m 3
  • the total volume is about 7.1m 3 (excluding pipeline) .
  • the lyophilizer is cleaned and dried according to the conventional method, 15 pieces of biological indicator (including spore amount 10 6 ) are placed as shown in the figure below, the box door is closed, and the air inlet of the front box of the lyophilizer is passed through the hose.
  • the drain port of the lyophilizer back box is connected to the air inlet 7 of the device of the invention through a hose, thus forming a closed loop, that is, the atomized hydrogen peroxide particles are first passed through the air inlet of the lyophilizer
  • the water outlet of the rear tank of the freeze dryer is discharged, and then enters the apparatus of the present invention through the air inlet 7 of the apparatus of the present invention, and the cycle is repeated.
  • the freeze dryer is turned on at the same time to lift the shelf 1-2 times.
  • the equipment When the added disinfectant is completely atomized, the equipment is turned off and the lyophilized lyophilizer is sealed for 2 hours, and the lyophilizer shelf is lifted 1-2 times during the sealing process. After the airtightness is completed, the water circulation vacuum pump of the lyophilizer is turned on, and the residual disinfectant is removed by vacuuming for 30 minutes, and the biological indicator (spore strip) is taken out and placed in the corresponding number of thermophilic fatty spore culture solution, and cultured and observed in the same manner as above.
  • the biological indicator spore strip
  • the transmission window sometimes needs to transmit certain special items (such as pens, recording paper, etc.), and the disinfection method of using ultraviolet light irradiation is basically unable to achieve the sterilization effect.
  • This test uses 3%. The active hydrogen peroxide disinfectant was subjected to a sterilization test on the transfer window.
  • Biological indicator (Bacillus stearothermophilus spore, spore amount 10 6 ), containing supporting chemical indicator and TSB liquid medium (produced by Beijing Jinsihuan Technology Co., Ltd.);
  • the length, width and height are 0.8m ⁇ 1.0m ⁇ 0.8m and the volume is 0.64m 3 .
  • two holes of the size of the inlet and outlet of the ultra-dry mist generator of the present invention are opened by the hole opener, and the orifice of the lower end of the transfer window is atomized and sterilized by a hose.
  • Air outlet of the device When connected, the hole at the upper end of the transfer window is connected with the air inlet 7 of the ultra-dry mist generator of the present invention by a hose to form a closed loop, that is, the atomized hydrogen peroxide particles first pass through the orifice at the lower end of the transfer window.
  • the transfer window After entering the transfer window, it is discharged through the orifice at the lower end of the transfer window, and then enters the ultra-dry mist generator through the air inlet 7 of the ultra-dry mist generator, so that the cycle is repeated, when 3% is added.
  • the active hydrogen peroxide disinfectant was atomized by 4 ml, the device was closed and sealed for 2 hours.
  • the biological indicator spore strip
  • the biological indicator is taken out, placed in the corresponding number of thermophilic fatty spore culture solution, cultured at 55-60 ° C, and one tablet of the same batch of bacteria is taken as a positive control, and the indicator is observed.
  • the present invention has the following advantages:
  • drying separation device 4 including the primary separator, the secondary separator and the tertiary separator for the first time, and then dry and separate the disinfectant particles (less than 10 ⁇ m) sprayed through the atomizing nozzle.
  • the large particles are dried into small particles, or condensed into a liquid and returned to the liquid storage device 1 to be re-sprayed into small particles;
  • the concentration of the hydrogen peroxide disinfectant used is less than 10%, the disinfectant particles finally produced by the present invention are less than 1 ⁇ m; when the concentration of the hydrogen peroxide disinfectant used is 6%, the disinfectant particles finally produced by the present invention are smaller than 0.5 ⁇ m ⁇ m (mainly concentrated between 0.3 and 0.5 ⁇ m); theoretically, when the concentration of the hydrogen peroxide disinfectant used is less than 1%, the final disinfectant particles produced by the present invention are less than 0.1 ⁇ m (up to the nanometer scale). It is superior to all current hydrogen peroxide disinfectant atomization technology, and is superior to the clinically widely used nebulization technology, such as the nebulization technique used for the prevention and treatment of interstitial plasma cell pneumonia. The particle size is only between 1-5 ⁇ m;
  • the concentration of the hydrogen peroxide disinfectant used can be reduced to below 3%, which greatly reduces the corrosion of hydrogen peroxide on the epoxy floor and the color steel plate. It also improves the efficiency of sterilization and sterilization;
  • the invention can be used not only for sterilization of rooms such as GMP purification workshops, hospital operating rooms and ICU wards, but also for sterilization of closed chambers such as freeze dryers, transfer windows and biological safety cabinets.
  • the hydrogen peroxide atomized particles have an particle diameter of less than 1 ⁇ m and do not contain moisture, and are an absolutely dry particle whose particle size can be measured by a dust particle detector.
  • the existing hydrogen peroxide dry mist technology such as the hydrogen peroxide dry fog equipment produced by OXYPHARM (type OXY-2500, particle size after atomization is about 5 ⁇ m), is used for workshop sterilization.
  • the distance between the atomizing outlet and the color steel plate wall and the epoxy floor must be greater than 2 m, otherwise corrosion will occur, especially when the atomizing outlet and the color steel plate wall When the distance between them is less than 1m, it can be found that the color steel plate wall is wetted and strongly corroded.
  • the particle size after atomization can not be measured by the dust particle detector within the distance of 1m, because the dust particle detector at this time The probe will also be wetted to cause serious contamination.
  • the invention is safe and efficient when used for sterilization and sterilization, the sterilization process is uninterrupted, the cycle period is short, no harm to the human body, no damage to the surface of the device and the wall and the ground, and the active hydrogen peroxide disinfectant is used, It has the advantages of no residue and no pollution after sterilization. It is a kind of green disinfection equipment that can completely replace formaldehyde disinfection.

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Disinfection, Sterilisation Or Deodorisation Of Air (AREA)

Abstract

一种超干雾发生器，包括：储液装置（1）、雾化装置（3）、风机（2）和顶部设有开口（44）的干燥分离装置（4），干燥分离装置（4）设置在储液装置（1）上方并与储液装置（1）连通，雾化装置（3）位于储液装置（1）外部，雾化装置（3）两端分别与风机（2）、干燥分离装置（4）内部连通，雾化装置（3）还与储液装置（1）连通，风机（2）将进入雾化装置（3）内的液体吹至干燥分离装置（4）内部。消毒液体从储液装置（1）进入雾化装置（3），雾化装置（3）将液体雾化成小颗粒，并在风机（2）驱动下经干燥分离装置（4）进行干燥后排至待消毒空间；雾化后的液体小颗粒粒径较小，与细菌大小更为接近，能够长时间悬浮在空气中并与细菌充分接触，腐蚀较小，方便安全。

Description

一种超干雾发生器 技术领域
本发明涉及卫生消毒领域，特别涉及一种超干雾发生器。
背景技术
微生物广泛存在于自然界中，当环境适宜时，微生物会迅速生长繁殖，造成污染，因此，在某些特殊环境中，需要进行消毒和灭菌。
在制药行业中，消毒灭菌作业必不可少，我国目前大部分的企业对GMP(Good Manufacturing Practice良好作业规范)车间进行消毒灭菌，主要采用甲醛熏蒸以及臭氧或者紫外灯照射的方式。甲醛熏蒸虽然是一种高水平的灭菌方式，但毒性较大，长期、低浓度接触甲醛会引起头痛、头晕、乏力、感觉障碍、免疫力降低，并可出现瞌睡、记忆力减退或神经衰弱、精神抑郁；慢性中毒对呼吸***的危害巨大，长期接触甲醛可引发呼吸功能障碍和肝中毒性病变，表现为肝细胞损伤、肝辐射能异常等。在发达国家已禁止在GMP车间使用；采用臭氧或者紫外灯照射，虽然使用安全，但只能部分降低微生物的水平，消毒水平较低，很难达到杀灭微生物的目的。
在实现本发明的过程中，发明人发现现有技术至少存在以下问题：
目前的消毒方式要么消毒效果较差，要么毒性较大，要么消毒时间较长。
发明内容
为了解决现有技术消毒效果较差、时间长及毒性大的问题，本发明实施 例提供了一种超干雾发生器。所述技术方案如下：
一种超干雾发生器，所述超干雾发生器包括：储液装置、雾化装置、风机和顶部设有开口的干燥分离装置，所述干燥分离装置设置在所述储液装置上方，且所述干燥分离装置与所述储液装置连通，所述雾化装置位于所述储液装置外部，所述雾化装置两端分别与所述风机、所述干燥分离装置内部连通，且所述雾化装置还与储液装置连通，风机将进入雾化装置内部的液体吹至干燥分离装置内部。
作为优选，所述干燥分离装置包括至少两个连通的空腔结构，所述干燥分离装置的底部与所述储液装置的顶部连接，且与所述储液装置的内部连通。
作为优选，所述干燥分离装置包括从下至上依次连通的第一空腔结构、第二空腔结构和第三空腔结构，所述第一空腔结构、所述第二空腔结构和所述储液装置呈一体式结构，所述第二空腔结构与所述第三空腔结构活动连接，所述第三空腔结构顶部设置有所述开口。
作为优选，所述雾化装置为雾化喷头，所述风机为高速热风电机。
作为优选，所述雾化喷头的进口与所述高速热风电机的出风口连通，所述雾化喷头的出口与所述第一空腔结构内部连通。
作为优选，所述储液装置底部设置有通孔，所述通孔通过管道与所述雾化喷头内部连通，储液装置内部液体经通孔、管道，进入所述雾化喷头内部。
进一步地，所述超干雾发生器还包括外壳，所述储液装置、雾化装置、风机与干燥分离装置均设置在所述外壳内部，所述外壳上设置有穿孔，所 述高速热风电机的进风口通过所述穿孔与外界连通。
进一步地，所述超干雾发生器还包括第一支架和第二支架，所述第一支架设置在所述外壳内部的底板与所述风机之间，用于支撑所述风机，所述第二支架设置在所述风机与所述第三空腔结构之间，用于支撑所述第三空腔结构。
进一步地，所述超干雾发生器还包括电路控制器，所述电路控制器与所述风机连接。
更进一步地，所述超干雾发生器还包括滚轮，所述外壳的底部设置有多个滚轮。
本发明实施例提供的技术方案带来的有益效果是：
本发明中消毒用液体从储液装置进入雾化装置，通过雾化装置将液体雾化成小颗粒，并在风机驱动下经干燥分离装置进行干燥后排至待消毒空间，进行消毒作业；本发明雾化后的消毒液体小颗粒，其粒径较小，其与细菌大小更为接近，能够长时间悬浮在空气中，并与空气中的细菌充分接触而达到杀菌目的，而对消毒空间内物体的腐蚀较小，方便且安全；另外，本发明结构简单且成本较低。
附图说明
为了更清楚地说明本发明实施例中的技术方案，下面将对实施例描述中所需要使用的附图作简单地介绍，显而易见地，下面描述中的附图仅仅是本发明的一些实施例，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其他的附图。
图1是本发明实施例提供的超干雾发生器的结构示意图。
其中：1储液装置，11通孔，
2风机，
3雾化装置，
4干燥分离装置，44开口，
41第一空腔结构，42第二空腔结构，43第三空腔结构
5第二支架，
6第一支架，
7外壳，71穿孔，72滚轮。
具体实施方式
为使本发明的目的、技术方案和优点更加清楚，下面将结合附图对本发明实施方式作进一步地详细描述。
如图1所示，本发明提供了一种超干雾发生器，所述超干雾发生器包括：储液装置1、雾化装置3、风机2和顶部设有开口44的干燥分离装置4，所述干燥分离装置4设置在所述储液装置1上方，且所述干燥分离装置4与所述储液装置1连通，所述雾化装置3位于所述储液装置1外部，所述雾化装置3两端分别与所述风机2、所述干燥分离装置4内部连通，且所述雾化装置3还与储液装置1连通，风机2将进入雾化装置3内部的液体吹至干燥分离装置4内部。
其中，干燥分离装置4与储液装置1连通，配置适合于待消毒细菌的消毒用液体，将其存至储液装置1，使用时，消毒用液体由储液装置1进入雾 化装置3，通过雾化装置3将液体雾化成液体小颗粒，在风机2的吹动下，使得液体小颗粒进入干燥分离装置4，并沿干燥分离装置4内壁向上移动，并最终从干燥分离装置4顶部的开口44排至待消毒空间，而未被干燥的较大液体颗粒则通过干燥分离装置4的内壁凝聚成溶液回流再进入储装置中；消毒用液体还可通过该开口44加入储液装置1，即该开口44可作为液体的加入口；
在液体小颗粒沿干燥分离装置4内壁向上移动过程中，风机2的吹动使得液体小颗粒在干燥分离装置4中不断干燥分离，其粒径进一步缩小，含水量进一步降低，绝大部分可达到小于1μm，甚至部分可达到0.1μm，液体小颗粒能够长时间悬浮在空气中并与空气中的细菌充分接触而达到杀菌目的；而含水量进一步降低，可大大降低对待消毒空间内设备的腐蚀；且实验表明，消毒用液体浓度越小，其雾化成液体小颗粒的粒径越小，因此，采用较低浓度的消毒用液体，可大大减小对消毒空间内物体的腐蚀，同时还提高了消毒灭菌的效率，方便且安全；另外，本发明结构简单且成本较低，特别适合于密闭空间的消毒和灭菌，如用于GMP净化车间、医院手术室、ICU病房、冷冻干燥机、传递窗和生物安全柜等的消毒灭菌。配合活性过氧化氢使用，具有灭菌后无残留、无污染等优点，是一种可取代甲醛的理想消毒灭菌设备。
如图1所示，作为优选，所述干燥分离装置4包括至少两个连通的空腔结构，所述干燥分离装置4的底部与所述储液装置1的顶部连接，且与所述储液装置1的内部连通。
如图1所示，作为优选，本发明实施例中，所述干燥分离装置4包括从 下至上依次连通的第一空腔结构41、第二空腔结构42和第三空腔结构43，所述第一空腔结构41、所述第二空腔结构42和所述储液装置1呈一体式结构，所述第二空腔结构42与所述第三空腔结构43活动连接，所述第三空腔结构43顶部设置有所述开口44。
其中，干燥分离装置4包括至少两个连通的空腔结构，即至少两级分离器，空腔结构的腔室的形状可以是圆形、方形或其他任何形状，各个空腔结构之间可以通过管道或带孔的隔板相连接，但必须保证加入的消毒液体能够完全流入至储液装置1中而没有明显残留，同时还要保证通过干燥分离装置4内壁凝聚的消毒液体也完全再回流进入储液装置1中而没有明显残留，最后一级分离器(本实施例中的第三空腔结构43)的上部开有开口44，作为干燥分离后的消毒液体干雾粒子(粒径小于1μm)的喷雾出口，同时还作为消毒液体的加入口；第一空腔结构41、第二空腔结构42和储液装置1呈一体式结构，可以防止漏液漏气。
如图1所示，作为优选，所述雾化装置3为雾化喷头，所述风机2为高速热风电机。
如图1所示，作为优选，所述雾化喷头的进口与所述高速热风电机的出风口连通，所述雾化喷头的出口与所述第一空腔结构41内部连通。
其中，本发明实施例中，高速热风电机吹出的是热风，在将雾化的液体小颗粒吹入干燥分离装置4内部，并沿内壁向上移动过程中，容易使得液体小颗粒进一步脱水，含水量进一步降低，在达到更小粒径与空气中的细菌充分接触的同时，也进一步降低对对待消毒空间内设备的腐蚀；高速热风电机的进风口配有接口，方便连接软管与待消毒灭菌的密闭空间如冷冻 干燥机、传递窗和生物安全柜等相连通，高速热风电机的出风口也配有接口，方便通过管道与雾化喷头的进口相连通；雾化喷头可为气动雾化喷头，可借助高速热风电机产生的高速射流空气，对消毒液体进行破碎雾化为消毒液体小颗粒后再喷入干燥分离装置4中；
雾化喷头首选双流体雾化喷嘴(气动喷嘴)，一方面要确保在消毒液体的出口处形成负压，方便将消毒液体从储液装置1吸入雾化喷头中，另一方面要保证较大的雾化面积，从而使从雾化喷头喷雾出来的消毒液小颗粒充分大面积地在第一空腔结构41中进行扩散干燥，从而形成更小的消毒液颗粒，没有被干燥的大颗粒一部分进入第二或第三空腔结构43再一次被干燥形成更小颗粒，另一部分没有被干燥的较大颗粒则凝聚成液体回流进入储液装置1中进行再次雾化，如此往复，即达到了大小颗粒完全干燥、分离的目的。
如图1所示，作为优选，所述储液装置1底部设置有通孔11，所述通孔11通过管道与所述雾化喷头内部连通，储液装置1内部液体经通孔11、管道，进入所述雾化喷头内部。
其中，本发明实施例中，储液装置1采用储液桶，其首选圆形或方形，底部开有通孔11，通过管道与雾化喷头相连接，也可对储液装置1配有液位计，以观察计算喷雾体积的大小及定量加入的消毒液体雾化后有没有残留。
如图1所示，进一步地，所述超干雾发生器还包括外壳7，所述储液装置1、雾化装置3、风机2与干燥分离装置4均设置在所述外壳7内部，所述外壳7上设置有穿孔71，所述高速热风电机的进风口通过所述穿孔71与 外界连通。
其中，外壳7的设置可对本发明实施例中各个部件进行固定，穿孔71的设置可为高速热风电机提供风源。
如图1所示，进一步地，所述超干雾发生器还包括第一支架6和第二支架5，所述第一支架6设置在所述外壳7内部的底板与所述风机2之间，用于支撑所述风机2，所述第二支架5设置在所述风机2与所述第三空腔结构43之间，用于支撑所述第三空腔结构43。
进一步地，所述超干雾发生器还包括电路控制器，所述电路控制器与所述风机2连接。
如图1所示，更进一步地，所述超干雾发生器还包括滚轮72，所述外壳7的底部设置有多个滚轮72。
本发明实施例中，采用实验方式进行实际分析：
一.干雾粒子的粒径大小及分布
以过氧化氢消毒剂为例，对雾化后的粒子大小进行了测定。由于本发明产生的雾化粒子是一种非常干燥且大部分粒径小于1微米，其粒径不适合用常规的激光粒谱测试仪进行测定(注：该技术只适合测定粒径大于1微米的粒子)，因此我们采用专用的尘埃粒子检测仪对其粒径大小及分布进行测定。
1.主要实验材料和设备
CLJ-BII(D)型尘埃粒子计数器，6％
Figure PCTCN2016087405-appb-000001
活性过氧化氢消毒液(杀孢子剂，执行标准Q/HHP 001-2015)，内含6％的过氧化氢和50ppm活性银离子(湖北荷普药业股份有限公司生产)；
2.试验场地
制药企业GMP厂房内一净化车间，车间高2.8m,宽4.4m，长6.5m,空间总体积约80m3。
3.实验方法
参照CLJ-BII(D)型尘埃粒子计数器使用说明书，开启尘埃粒子检测仪器电源开关，设置好相关参数(测试周期：60s，采样量：28.3L/min),将尘埃粒子检测仪器采样管口分别放置在离超干雾发生器雾化出口0.25m、0.5m和1m处检测过氧化氢消毒液雾化后所产生的粒子大小及分布。
4.实验结果
不同大小的粒子所对应的数量试验结果见表1所示。统计结果见表2所示。由表1和表2可知，本发明的超干雾发生器对6％过氧化氢消毒液雾化后所产生粒子的粒径绝大部分小于1μm(占60％以上)，主要分布在0.3-0.5μm之间。随着测定距离的增加，小粒子数有所增加，大粒子数有所减少，但当测定距离大于0.5m后测定结果无明显变化。这说明所用过氧化氢消毒液经过本发明的干雾设备雾化干燥后是一种真正意义上的干雾。理论上讲，由于所使用过氧化氢消毒液的浓度小于10％，因此经过本发明技术初次雾化后的粒子(小于10μm)经过干燥分离后必然会变为更小粒子(至少浓缩90％，即小于1μm)。而现有技术的消毒液雾化灭菌设备由于雾化的粒子含有大量水分(90％以上)，即使雾化后的粒径小于5μm，其雾化出口如果离被消毒物体太近(小于1m)，也会将被消毒的物体进行湿润而产生严重腐蚀。
表1.本发明实施例对6％过氧化氢消毒液雾化后实测粒子大小及数量
Figure PCTCN2016087405-appb-000002
表2.统计后不同大小粒子分布结果
Figure PCTCN2016087405-appb-000003
二.用于制药企业GMP车间消毒灭菌试验
1.主要实验材料和设备
欧菲姆干雾灭菌设备(法国欧菲姆(OXYPHARM)公司生产，型号OXY-25000)；生物指示剂(嗜热脂肪芽孢杆菌孢子，孢子量106)，含配套化学指示剂和TSB液体培养基(北京金四环科技有限责任公司生产)，下同；6％
Figure PCTCN2016087405-appb-000004
活性过氧化氢消毒液(杀孢子剂，执行标准Q/HHP 001-2015)，同上；3％
Figure PCTCN2016087405-appb-000005
活性过氧化氢消毒液，由6％
Figure PCTCN2016087405-appb-000006
活性过氧化氢消毒 液加等体积的纯化水稀释而成，下同。
2.试验场地
制药企业GMP厂房内一净化车间，车间高2.8m,宽4.4m，长6.5m,空间总体积约80m3。
3.实验方法
在环境温度、湿度及过氧化氢消毒液的浓度和用量相同的条件下，分明用本发明的超干雾发生器和欧菲姆干雾灭菌设备对上述80m3的GMP车间进行了消毒灭菌试验。根据车间空间大小，均按5ml/m3喷雾量即400ml
Figure PCTCN2016087405-appb-000007
Figure PCTCN2016087405-appb-000008
活性过氧化氢消毒液进行喷雾消毒。喷雾时两种设备均置于车间正中间，5片生物指示剂分别放置在车间中间(编号3)和四个不同角落(设备喷雾头前方两个角落点编号分别为1和2，设备喷雾头后方角落两个点编号分别为4和5)，所有生物指示剂离地面的高度均为1m，当消毒液喷雾完毕后，将房间密闭2小时，取出生物指示剂(芽孢条)，放入对应编号的嗜热脂肪芽孢培养液中，按照所购生物指示剂的使用说明书，置于恒温培养箱中，在50℃-55℃培养箱中培养48h后观察。同时取同批生物指示剂1片作阳性对照。经过48小时的培养，若培养液变浑浊，颜色由紫色变为黄色则判定为阳性；若培养液澄清，颜色不变色则为阴性；继续培养至第7天，仍无菌生长则为合格。
4.实验结果
实验结果见表3所示。由表3可知，当喷雾量为5ml/m3，活性过氧化氢消毒液的浓度为6％时，两种灭菌设备均可达到灭菌的要求，即均可杀死106的孢子；而当喷雾量均为5ml/m3，活性过氧化氢消毒液的浓度下降至 3％时，则欧菲姆干雾灭菌设备达不到灭菌要求，而本发明的超干雾发生器仍可达到灭菌要求。这说明本发明的超干雾发生器用于GMP车间消毒灭菌时，其杀菌能力更强，灭菌效果更加好，因而优于现有产品。
表3.本发明与市购欧菲姆干雾灭菌设备灭菌效果比较
Figure PCTCN2016087405-appb-000009
三.用于传统冷冻干燥机的消毒灭菌试验
目前传统冷冻干燥机(不具备SIP功能)因不耐高压，不宜用蒸汽灭菌的方式进行灭菌，故常采用臭氧灭菌的方式。但由于冻干机内部结构复杂，臭氧灭菌方式很难达到灭菌效果，本试验采用6％
Figure PCTCN2016087405-appb-000010
活性过氧化氢消毒液对传统冻干机进行了灭菌试验。
1.主要实验材料
同上。
2.试验冻干燥机
上海浦东GLZY-13B冻干机(具备在位清洗，CIP功能，不具备SIP功能)，前箱体积为3.3m3，后箱体积为3.8m3，总体积约7.1m3(不含管道)。
3.实验方法
先按常规方法对冻干机进行清洗干燥后，按照下图所示布置摆放15片生物指示剂(含孢子量106)，关闭箱门，将冻干机前箱进气口通过软管与本发明的超干雾灭菌设备的喷雾出口
Figure PCTCN2016087405-appb-000011
相连接，将冻干机后箱的排水口通过软管与本发明设备的进风口⑦相连接，如此形成闭合回路，即雾化后的过氧化氢粒子先通过冻干机的进气口依次进入冻干机的前箱、后箱，经由冻干机后箱出水口排出后再通过本发明设备的进风口⑦进入本发明设备，如此反复循环。雾化过程中，同时开启冻干机使搁板升降1-2次。当加入的消毒液被全部雾化完后，将设备关闭并将雾化灭菌后的冻干机密闭2小时，密闭过程中也使冻干机搁板升降1-2次。密闭结束后，开启冻干机的水循环真空泵，抽真空30分钟排除残留的消毒液，取出生物指示剂(芽孢条)，放入对应编号的嗜热脂肪芽孢培养液中，同上法进行培养观察。
4.实验结果
实验结果见表4所示。由表4可知，当活性过氧化氢消毒液的浓度为6％，喷雾量为10ml/m3时，本发明的超干雾发生器可以对传统冻干机(不具备SIP功能)进行消毒灭菌，消毒灭菌2小时就达到灭菌要求(使芽孢下降六个对数)。
表4.用于传统冷冻干燥机消毒灭菌生物指示剂检测结果
Figure PCTCN2016087405-appb-000012
四.用于传递窗的消毒灭菌试验
目前传递窗有时因需要传递某些特殊物品(如笔、记录纸等)，多用紫外灯照射的消毒方式，根本上达不到灭菌效果，本试验采用3％
Figure PCTCN2016087405-appb-000013
活性过氧化氢消毒液对传递窗进行了消毒灭菌试验。
1.主要实验材料
生物指示剂(嗜热脂肪芽孢杆菌孢子，孢子量106)，含配套化学指示剂和TSB液体培养基(北京金四环科技有限责任公司生产)；
3％
Figure PCTCN2016087405-appb-000014
活性过氧化氢消毒液，用6％
Figure PCTCN2016087405-appb-000015
活性过氧化氢消毒液加等体积的纯化水稀释制成；
2.试验传递窗
江苏林森公司生产，长宽高分别为0.8m×1.0m×0.8m,体积为0.64m3。
3.实验方法
先用开孔器将传递窗一边门的上下两端开2个大小与本发明超干雾发生器的进出口大小一致的孔口，用软管将传递窗下端的孔口与雾化灭菌设备的出气口
Figure PCTCN2016087405-appb-000016
相连接，同时用软管将传递窗上端的孔口与本发明超干雾发生器的进风口⑦相连接，形成闭合回路，即雾化后的过氧化氢粒子先通过传递窗下端的孔口进入传递窗、再通过传递窗下端的孔口排出后又通过超干雾发生器的进风口⑦进入超干雾发生器中，如此反复循环，当加入的3％
Figure PCTCN2016087405-appb-000017
Figure PCTCN2016087405-appb-000018
活性过氧化氢消毒液被雾化4ml后，将设备关闭并密闭2小时。密闭结束后，取出生物指示剂(芽孢条)，放入对应编号的嗜热脂肪芽孢培养液中，置55-60℃条件下培养，同时取同批菌片1片作阳性对照，观察指示剂培养结果，经48小时培养后，若培养液变浑浊，颜色由紫色变为黄色则判定为阳性；若培养液澄清，颜色不变色则为阴性，如果培养保持紫色不变，则视为无菌生长。
4.实验结果
实验结果见表5所示。由表5可知，当活性过氧化氢消毒液的浓度为3％，喷雾量为5ml/m3，即可对传递窗进行灭菌，并能满足灭菌要求(使芽孢下降六个对数)。
表5.用于传递窗消毒灭菌生物指示剂检测结果
Figure PCTCN2016087405-appb-000019
综上，本发明具有如下优点：
1.由于采用了高速热风电机与双流体雾化喷头组成雾化***，不仅成本较低，而且还可利用高速热风电机产生的热风对喷雾后的消毒液粒子进行浓缩干燥；
2.首次引入干燥分离装置4(包括一级分离器、二级分离器和三级分离器)对经过雾化喷头喷雾后的消毒液粒子(小于10μm)再进行多次的干燥和分离，使大粒子干燥成小粒子，或者凝聚为液体返回至储液装置1中重新喷雾成为小粒子；
3.当所用过氧化氢消毒液的浓度小于10％时，本发明最终产生的消毒剂粒子小于1μm；当所用过氧化氢消毒液的浓度为6％时，本发明最终产生的消毒剂粒子小于0.5μmμm(主要集中在0.3-0.5μm之间)；理论上讲，当所用过氧化氢消毒液的浓度小于1％时，本发明最终产生的消毒剂粒子小于0.1μm(达到纳米级)。优于现在所有的过氧化氢消毒液雾化技术，也优于临床上广泛使用的雾化吸入技术，如用于预防和治疗间质性浆细胞性肺炎的所用雾化吸入技术，其雾化粒径均只在1-5μm之间；
4.本发明用于空间消毒灭菌时，所使用的过氧化氢消毒液浓度可降低至3％以下，极大地降低了过氧化氢对环氧地面和彩钢板造成的腐蚀，同时 还提高了消毒灭菌的效率；
5.本发明不仅可用于房间如GMP净化车间、医院手术室和ICU病房的消毒灭菌，而且还可用于密闭腔室如冷冻干燥机、传递窗和生物安全柜等的消毒灭菌。
6.本发明在用于GMP净化车间消毒灭菌时，即使干燥分离装置4顶部开口44离彩钢板墙壁和环氧地面之间的距离小于0.5m，也不会产生腐蚀，因为本发明产生的过氧化氢雾化粒子的粒径小于1μm，且不含水分，是一种绝对干燥的粒子，其粒径大小可以用尘埃粒子检测仪进行测定。而现有的过氧化氢干雾技术如法国欧菲姆(OXYPHARM)公司生产的过氧化氢干雾设备(型号OXY-2500，雾化后粒子粒径为5μm左右)在用于车间消毒灭菌时，因其雾化粒子含有大量水分，其雾化出口与彩钢板墙壁和环氧地面之间的距离必须大于2m以上，否则就会产生腐蚀，特别是当其雾化出口与彩钢板墙壁之间的距离小于1m时就可发现彩钢板墙壁被浸湿而产生强烈腐蚀，其雾化后粒径的大小在1m的距离以内均无法用尘埃粒子检测仪进行测定，因为此时尘埃粒子检测仪的探头也会被浸湿而产生严重污染。
7.本发明用于消毒灭菌时，安全高效，灭菌过程不间断，循环周期短，对人体无伤害，对设备表面及墙壁和地面均无损害，配合活性过氧化氢消毒液使用，具有灭菌后无残留、无污染的优点，是一种完全可以取代甲醛消毒的绿色环保消毒设备。
以上所述仅为本发明的较佳实施例，并不用以限制本发明，凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。

Claims (10)

  1. 一种超干雾发生器，其特征在于，所述超干雾发生器包括：储液装置、雾化装置、风机和顶部设有开口的干燥分离装置，所述干燥分离装置设置在所述储液装置上方，且所述干燥分离装置与所述储液装置连通，所述雾化装置位于所述储液装置外部，所述雾化装置两端分别与所述风机、所述干燥分离装置内部连通，且所述雾化装置还与储液装置连通，风机将进入雾化装置内部的液体吹至干燥分离装置内部。
  2. 根据权利要求1所述的超干雾发生器，其特征在于，所述干燥分离装置包括至少两个连通的空腔结构，所述干燥分离装置的底部与所述储液装置的顶部连接，且与所述储液装置的内部连通。
  3. 根据权利要求2所述的超干雾发生器，其特征在于，所述干燥分离装置包括从下至上依次连通的第一空腔结构、第二空腔结构和第三空腔结构，所述第一空腔结构、所述第二空腔结构和所述储液装置呈一体式结构，所述第二空腔结构与所述第三空腔结构活动连接，所述第三空腔结构顶部设置有所述开口。
  4. 根据权利要求3所述的超干雾发生器，其特征在于，所述雾化装置为雾化喷头，所述风机为高速热风电机。
  5. 根据权利要求4所述的超干雾发生器，其特征在于，所述雾化喷头的进口与所述高速热风电机的出风口连通，所述雾化喷头的出口与所述第一空腔结构内部连通。
  6. 根据权利要求5所述的超干雾发生器，其特征在于，所述储液装置底部设置有通孔，所述通孔通过管道与所述雾化喷头内部连通，储液装置内部液体经通孔、管道，进入所述雾化喷头内部。
  7. 根据权利要求6所述的超干雾发生器，其特征在于，所述超干雾发生器还包括外壳，所述储液装置、雾化装置、风机与干燥分离装置均设置在所述外壳内部，所述外壳上设置有穿孔，所述高速热风电机的进风口通过所述穿孔与外界连通。
  8. 根据权利要求7所述的超干雾发生器，其特征在于，所述超干雾发生器还包括第一支架和第二支架，所述第一支架设置在所述外壳内部的底板与所述风机之间，用于支撑所述风机，所述第二支架设置在所述风机与所述第三空腔结构之间，用于支撑所述第三空腔结构。
  9. 根据权利要求8所述的超干雾发生器，其特征在于，所述超干雾发生器还包括电路控制器，所述电路控制器与所述风机连接。
  10. 根据权利要求9所述的超干雾发生器，其特征在于，所述超干雾发生器还包括滚轮，所述外壳的底部设置有多个滚轮。
PCT/CN2016/087405 2016-01-28 2016-06-28 一种超干雾发生器 WO2017128610A1 (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP16820143.2A EP3238748A4 (en) 2016-01-28 2016-06-28 Ultra-dry fog generator
US15/315,693 US10188765B2 (en) 2016-01-28 2016-06-28 Super dry fog generator

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201610058240.6A CN105597133B (zh) 2016-01-28 2016-01-28 一种超干雾发生器
CN201610058240.6 2016-01-28

Publications (1)

Publication Number Publication Date
WO2017128610A1 true WO2017128610A1 (zh) 2017-08-03

Family

ID=55977835

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2016/087405 WO2017128610A1 (zh) 2016-01-28 2016-06-28 一种超干雾发生器

Country Status (4)

Country Link
US (1) US10188765B2 (zh)
EP (1) EP3238748A4 (zh)
CN (1) CN105597133B (zh)
WO (1) WO2017128610A1 (zh)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10188765B2 (en) 2016-01-28 2019-01-29 Hubei Hope Pharmaceutical Co., Ltd. Super dry fog generator
CN110680942A (zh) * 2019-09-30 2020-01-14 杭州易路医疗器械有限公司 侧喷式超声波雾化消毒装置及其消毒方法
CN113769142A (zh) * 2021-10-21 2021-12-10 苏州清乐智能科技有限公司 摇摆式雾化消毒机

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106075510B (zh) * 2016-08-02 2022-04-01 湖北荷普药业股份有限公司 一种气体灭菌设备
CN106178058A (zh) * 2016-08-10 2016-12-07 湖北荷普药业股份有限公司 一种纳米雾消毒灭菌装置
CN106344944B (zh) * 2016-08-30 2020-05-05 湖北荷普药业股份有限公司 一种脉动灭菌设备
CN106942269B (zh) * 2017-03-21 2019-09-17 湖北荷普药业股份有限公司 一种制备消毒剂纳米颗粒的装置
CN113069572A (zh) * 2020-01-06 2021-07-06 王夕芬 一种护理用轻质医疗器材消毒装置
CN112843270B (zh) * 2020-12-29 2022-12-06 江苏澳联科技开发有限公司 一种应用于冷链的消毒***及其消毒方法
CN112618743B (zh) * 2020-12-29 2022-07-01 江苏澳联科技开发有限公司 一种冷链仓库消毒***
CN112807983A (zh) * 2021-01-04 2021-05-18 上海应用技术大学 一种汽化过氧化氢除残设备
CN113546203A (zh) * 2021-07-01 2021-10-26 褚培忠 一种消毒剂干雾化的发生方法
CN114504669A (zh) * 2021-12-27 2022-05-17 正大农业科技(浙江)有限公司 一种无土栽培基质的安全消毒设备及消毒方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08131530A (ja) * 1994-11-04 1996-05-28 Tdk Corp 脱臭器
CN101237894A (zh) * 2005-08-04 2008-08-06 萨班有限公司 空间消毒
CN203694175U (zh) * 2013-12-27 2014-07-09 秦皇岛云立方环保工程有限公司 一种移动式干雾消毒灭菌装备
CN104984378A (zh) * 2015-06-17 2015-10-21 苏州大学张家港工业技术研究院 一种过氧化氢灭菌装置及方法
CN105597133A (zh) * 2016-01-28 2016-05-25 湖北荷普药业股份有限公司 一种超干雾发生器

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8029726B2 (en) 2007-05-22 2011-10-04 .Vapex Technologies, Inc. Disinfection methods for surfaces and enclosed spaces
GB201014820D0 (en) * 2010-09-07 2010-10-20 Norman Pendred And Company Ltd Delivery method

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08131530A (ja) * 1994-11-04 1996-05-28 Tdk Corp 脱臭器
CN101237894A (zh) * 2005-08-04 2008-08-06 萨班有限公司 空间消毒
CN203694175U (zh) * 2013-12-27 2014-07-09 秦皇岛云立方环保工程有限公司 一种移动式干雾消毒灭菌装备
CN104984378A (zh) * 2015-06-17 2015-10-21 苏州大学张家港工业技术研究院 一种过氧化氢灭菌装置及方法
CN105597133A (zh) * 2016-01-28 2016-05-25 湖北荷普药业股份有限公司 一种超干雾发生器

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10188765B2 (en) 2016-01-28 2019-01-29 Hubei Hope Pharmaceutical Co., Ltd. Super dry fog generator
CN110680942A (zh) * 2019-09-30 2020-01-14 杭州易路医疗器械有限公司 侧喷式超声波雾化消毒装置及其消毒方法
CN110680942B (zh) * 2019-09-30 2023-09-08 杭州易路医疗器械有限公司 侧喷式超声波雾化消毒装置及其消毒方法
CN113769142A (zh) * 2021-10-21 2021-12-10 苏州清乐智能科技有限公司 摇摆式雾化消毒机

Also Published As

Publication number Publication date
EP3238748A1 (en) 2017-11-01
US20170266331A1 (en) 2017-09-21
EP3238748A4 (en) 2017-11-01
US10188765B2 (en) 2019-01-29
CN105597133B (zh) 2017-11-17
CN105597133A (zh) 2016-05-25

Similar Documents

Publication Publication Date Title
WO2017128610A1 (zh) 一种超干雾发生器
Wu et al. Inactivation of bacteria and fungus aerosols using microwave irradiation
CN106178058A (zh) 一种纳米雾消毒灭菌装置
CN106822954B (zh) 一种室温汽化消毒灭菌***
CN105909000B (zh) 人流/物流无菌气锁间
Yan et al. A new filterless indoor air purifier for particulate matter and bioaerosol based on heterogeneous condensation
CN108624491B (zh) 一种可移动式pcr实验室
US20130071300A1 (en) Bills-only sterilizer
CN106942269B (zh) 一种制备消毒剂纳米颗粒的装置
CN106344944B (zh) 一种脉动灭菌设备
CN207545523U (zh) 一种制备消毒剂纳米颗粒的设备
CN205515662U (zh) Vhp灭菌传递柜
CN104996503B (zh) 一种用于养殖场的中药复方空气消毒喷雾剂及其制备方法
CN206151932U (zh) 一种具有消化分解功能的纳米雾消毒灭菌装置
CN2712354Y (zh) 负压换风消毒病房
CN114945658B (zh) 无化学杀菌剂的无菌细胞处理及生产
JP2008022764A (ja) 環境評価方法
CN203663127U (zh) 智能遗体消毒房
CN208332554U (zh) 一种利用中央空调凝结水的雾化装置
CN205515680U (zh) 一种纳米雾发生器
CN207462347U (zh) 一种护理消毒装置
CN206980780U (zh) 一种新型超净工作台
CN206875836U (zh) 一种生物实验烘干装置
CN220327715U (zh) 一种双锥干燥机用无菌隔离室
Ling et al. Evaluation of biological inactivation efficacy for in-duct pulsed xenon lamp

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 15315693

Country of ref document: US

REEP Request for entry into the european phase

Ref document number: 2016820143

Country of ref document: EP

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 16820143

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE