WO2017104627A1 - 超音波観測装置、超音波観測装置の作動方法および超音波観測装置の作動プログラム - Google Patents
超音波観測装置、超音波観測装置の作動方法および超音波観測装置の作動プログラム Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/46—Ultrasonic, sonic or infrasonic diagnostic devices with special arrangements for interfacing with the operator or the patient
- A61B8/467—Ultrasonic, sonic or infrasonic diagnostic devices with special arrangements for interfacing with the operator or the patient characterised by special input means
- A61B8/469—Ultrasonic, sonic or infrasonic diagnostic devices with special arrangements for interfacing with the operator or the patient characterised by special input means for selection of a region of interest
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
- A61B8/0833—Detecting organic movements or changes, e.g. tumours, cysts, swellings involving detecting or locating foreign bodies or organic structures
- A61B8/085—Detecting organic movements or changes, e.g. tumours, cysts, swellings involving detecting or locating foreign bodies or organic structures for locating body or organic structures, e.g. tumours, calculi, blood vessels, nodules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/12—Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/48—Diagnostic techniques
- A61B8/485—Diagnostic techniques involving measuring strain or elastic properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/5215—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data
- A61B8/5223—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data for extracting a diagnostic or physiological parameter from medical diagnostic data
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/54—Control of the diagnostic device
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/46—Ultrasonic, sonic or infrasonic diagnostic devices with special arrangements for interfacing with the operator or the patient
- A61B8/461—Displaying means of special interest
- A61B8/463—Displaying means of special interest characterised by displaying multiple images or images and diagnostic data on one display
Definitions
- the present invention relates to an ultrasonic observation apparatus that observes a tissue to be observed using ultrasonic waves, an operation method of the ultrasonic observation apparatus, and an operation program of the ultrasonic observation apparatus.
- ultrasonic elastography is known as a technique for diagnosing an observation target using ultrasonic waves (see, for example, Patent Document 1).
- Ultrasonic elastography is a technique that utilizes the fact that the hardness of cancer and tumor tissue in a living body varies depending on the progress of the disease and the living body.
- an elastic image in which information on the hardness of a living tissue is imaged is generated by performing coloring based on an average value of the displacement amount of the living tissue in a predetermined region of interest (ROI).
- ROI region of interest
- an observation for screening a tissue such as a tumor and an observation for examining the tissue are performed.
- the above-described conventional technique has a problem that the user has to change the size of the region of interest in accordance with the observation contents, and it takes time and effort to perform both screening and scrutiny.
- the present invention has been made in view of the above, and the operation of an ultrasonic observation apparatus and an ultrasonic observation apparatus that can easily perform both screening and inspection in ultrasonic elastography without taking time and effort. It is an object to provide a method and an operation program for an ultrasonic observation apparatus.
- an ultrasonic observation apparatus includes an ultrasonic transducer that transmits ultrasonic waves to an observation target and receives ultrasonic waves reflected by the observation target.
- An ultrasonic observation apparatus that performs observation based on an ultrasonic signal acquired by an ultrasonic probe provided, an ultrasonic image generation unit that generates ultrasonic image data based on the ultrasonic signal, and the ultrasonic wave
- a region-of-interest setting unit that automatically sets a relatively hard second region of interest among first regions of interest set in advance in the image, and according to the hardness of the first and second regions of interest
- an elastic image generation unit that generates data of first and second elastic images each having a display mode.
- the ultrasonic observation apparatus further includes a displacement amount calculation unit that calculates a displacement amount of the observation target in the first and second regions of interest in the above invention, and the region of interest setting unit includes the displacement
- the second region of interest is set based on the calculation result of the amount calculation unit, and the elastic image generation unit has a display mode corresponding to the displacement amount in the first and second regions of interest, respectively. And generating data of the second elastic image.
- the region-of-interest setting unit compares the displacement amount of each observation point in the first region of interest with a predetermined threshold value and compares the displacement from the threshold value.
- a region having a small amount is set as the second region of interest.
- the region-of-interest setting unit includes a region in which the displacement amount in the first region of interest is smaller than the threshold is spatially continuous by a predetermined number or more, and When the continuous region continues for a predetermined time, the region is set as the second region of interest.
- the region-of-interest setting unit extracts a contour of the observation target on the ultrasonic image, and the first region of interest is within the extracted region of the contour.
- a closed region having the outline as a boundary is set as the second region of interest.
- the ultrasonic observation apparatus generates an average image obtained by adding and averaging a plurality of ultrasonic images when receiving an input of a freeze instruction signal whose display on the display device is a still image in the above invention.
- the average image generation unit that generates data of the average image is further included, and the region-of-interest setting unit includes the observation point at each observation point in the first region of interest in the average image.
- An area having a displacement amount smaller than a predetermined threshold is set as the second region of interest.
- the region-of-interest setting unit includes a predetermined number of spatially continuous regions having the statistic smaller than the threshold in the first region of interest.
- the region is set as the second region of interest.
- the ultrasonic observation apparatus further includes a displacement amount storage unit that stores a displacement amount of each observation point of the first region of interest in the above invention, and the region of interest setting unit displays information on a display device.
- the displacement amount storage unit stores the With reference to the displacement amount at each observation point of the ultrasonic image, there is a region in which the displacement amount is smaller than a predetermined threshold value and coincides with a predetermined number or more of the plurality of ultrasonic images. In this case, the region is set as the second region of interest.
- the ultrasonic observation apparatus is the above-described invention, wherein the elastic image of a region obtained by removing the second region of interest from the first region of interest and the elastic image of the second region of interest can be identified.
- the image processing apparatus further includes a display control unit that causes the display device to display the image as one image having an aspect.
- the ultrasonic observation apparatus further includes a display control unit that causes the display device to display the elasticity image of the first region of interest and the elasticity image of the second region of interest in parallel in the above invention. It is characterized by that.
- An operation method of an ultrasonic observation apparatus is an ultrasonic signal acquired by an ultrasonic probe including an ultrasonic transducer that transmits ultrasonic waves to an observation target and receives ultrasonic waves reflected by the observation target.
- a region-of-interest setting step and a second elastic image generation step in which the elastic image generation unit generates data of a second elastic image having a display mode corresponding to the hardness of the second region of interest. It is characterized by having.
- the operation program of the ultrasonic observation apparatus is an ultrasonic signal acquired by an ultrasonic probe including an ultrasonic transducer that transmits ultrasonic waves to an observation target and receives ultrasonic waves reflected by the observation target.
- a display mode according to the hardness of the first region of interest set in advance in the ultrasonic image generated based on the ultrasonic signal in the ultrasonic observation apparatus that performs the observation based on the ultrasonic signal
- a region of interest in which a region of interest setting unit sets a relatively hard second region of interest within the first region of interest.
- a setting step; and a second elasticity image generation step in which the elasticity image generation unit generates data of a second elasticity image having a display mode corresponding to the hardness of the second region of interest. It is characterized by.
- FIG. 1 is a diagram schematically showing a configuration of an ultrasonic diagnostic system including an ultrasonic observation apparatus according to Embodiment 1 of the present invention.
- FIG. 2 is a flowchart showing an outline of processing performed by the ultrasound observation apparatus according to Embodiment 1 of the present invention.
- FIG. 3 is a diagram illustrating a display example of the elastic image of the first region of interest on the display device.
- FIG. 4 is a diagram illustrating a display example of the elastic image of the second region of interest on the display device.
- FIG. 5 is a diagram showing a display example on the display device of the second ROI elasticity image generated by the ultrasound observation apparatus according to the modified example 1-1 of the first embodiment of the present invention.
- FIG. 1 is a diagram schematically showing a configuration of an ultrasonic diagnostic system including an ultrasonic observation apparatus according to Embodiment 1 of the present invention.
- FIG. 2 is a flowchart showing an outline of processing performed by the ultrasound observation apparatus according to Embodiment 1 of the present invention
- FIG. 6 is a flowchart showing an outline of processing performed by the ultrasound observation apparatus according to Modification 1-2 of Embodiment 1 of the present invention.
- FIG. 7 is a diagram schematically showing a configuration of an ultrasonic diagnostic system including the ultrasonic observation apparatus according to Embodiment 2 of the present invention.
- FIG. 8 is a flowchart showing an outline of processing performed by the ultrasonic observation apparatus according to Embodiment 2 of the present invention.
- FIG. 9 is a flowchart showing an outline of processing performed by the ultrasonic observation apparatus according to Modification 2-1 of Embodiment 2 of the present invention.
- FIG. 10 is a diagram showing a display example on the display device for the elastic image of the second region of interest according to another embodiment of the present invention.
- FIG. 1 is a diagram schematically showing a configuration of an ultrasonic diagnostic system including an ultrasonic observation apparatus according to Embodiment 1 of the present invention.
- An ultrasonic diagnostic system 1 shown in FIG. 1 includes an ultrasonic endoscope 2, an ultrasonic observation device 3, and a display device 4.
- the ultrasonic endoscope 2 includes an ultrasonic transducer 21 that is provided at a distal end portion thereof, transmits ultrasonic waves to a subject to be observed, and receives ultrasonic waves reflected by the subject.
- the ultrasonic transducer 21 converts an electrical pulse signal received from the ultrasonic observation apparatus 3 into an ultrasonic pulse (acoustic pulse) and irradiates the subject, and electrically transmits an ultrasonic echo reflected by the subject. Converted into a typical echo signal (ultrasonic signal) and output.
- the ultrasonic transducer 21 may be an electronic scanning type or a mechanical scanning type.
- Various types of ultrasonic endoscopes 2 are known depending on observation objects such as the digestive tract (esophagus, stomach, duodenum, large intestine) and respiratory organs (trachea, bronchi) of a subject.
- the ultrasonic endoscope 2 includes an imaging unit that images the inside of the subject, a light guide that guides the illumination light from a light source device that generates illumination light to be irradiated to the subject at the time of imaging, to the distal end of the ultrasonic endoscope 2 May be further provided.
- the ultrasonic observation apparatus 3 transmits and receives electrical signals to and from the ultrasonic endoscope 2 via an ultrasonic cable.
- the ultrasonic observation apparatus 3 performs a predetermined process on the electrical echo signal received from the ultrasonic endoscope 2 to generate an ultrasonic image or the like.
- the ultrasonic observation apparatus 3 includes a transmission / reception unit 31 that transmits / receives signals to / from the ultrasonic transducer 21, and a signal processing unit 32 that generates digital reception data based on echo signals received from the transmission / reception unit 31.
- An input unit 33 that receives input of various information including an operation instruction signal of the ultrasonic observation apparatus 3, a region of interest setting unit 34 that sets a region of interest in an ultrasonic image, and an observation point (sampling point) in the region of interest
- the displacement amount calculation unit 35 for calculating the displacement amount between images in the image, the image generation unit 36 for generating data of various images including an ultrasonic image and an elasticity image, and the overall operation of the ultrasonic diagnostic system 1 are controlled in an integrated manner.
- movement of the ultrasonic observation apparatus 3 are provided.
- the ultrasonic observation apparatus 3 can set an elastography mode in which information related to the relative hardness of the observation target in the region of interest is imaged with visual information such as color.
- the transmission / reception unit 31 transmits a pulsed transmission drive wave signal to the ultrasonic transducer 21 based on a predetermined waveform and transmission timing.
- the transmission / reception unit 31 receives an electrical echo signal from the ultrasonic transducer 21.
- the transmission / reception unit 31 transmits various control signals output from the control unit 37 to the ultrasonic endoscope 2 and receives various types of information including an identification ID from the ultrasonic endoscope 2 and receives the control unit 37. It also has a function to transmit to.
- the signal processing unit 32 performs known processing such as bandpass filter, envelope detection, logarithmic conversion, and the like on the echo signal to generate digital ultrasonic image reception data (hereinafter referred to as reception data).
- the signal processing unit 32 is realized using a general-purpose processor such as a CPU (Central Processing Unit) or a dedicated integrated circuit that performs a specific function such as an ASIC (Application Specific Integrated Circuit) or FPGA (Field Programmable Gate Array). Is done.
- the input unit 33 receives an input of a signal instructing setting of a first region of interest (hereinafter referred to as a first ROI).
- the input unit 33 is configured using a user interface such as a keyboard, a mouse, and a touch panel.
- the region-of-interest setting unit 34 sets the first ROI based on the setting input received by the input unit 33.
- the region-of-interest setting unit 34 sets a relatively hard region in the first ROI as a second region of interest (hereinafter referred to as a second ROI) based on a calculation result of a displacement amount calculation unit 35 described later.
- the displacement amount calculation unit 35 is based on ultrasonic image data generated by an ultrasonic image generation unit 361 of the image generation unit 36 to be described later, and is an observation point in the region of interest corresponding to pressurization by the pulsation of the subject. The amount of tissue displacement at (sampling point) is calculated. The displacement amount calculation unit 35 calculates the displacement amount by comparing, for example, the latest ultrasonic image and the ultrasonic image generated one frame before.
- the image generation unit 36 visually generates information on the hardness of the tissue to be observed based on the amount of displacement in the region of interest and the ultrasonic image generation unit 361 that generates ultrasonic image data based on the received data.
- An elastic image generation unit 362 that generates an elastic image to be expressed.
- the ultrasonic image data generated by the ultrasonic image generation unit 361 is, for example, B-mode image data obtained by converting the amplitude into luminance.
- Elastic image generation unit 362 generates first and second elastic image data having display modes corresponding to the hardness of the first and second regions of interest.
- the elastic image generated by the elastic image generation unit 362 is an image obtained by giving visual information such as a color and a pattern to each point in the region of interest based on the calculation result of the displacement amount calculation unit 35. Specifically, the elastic image generation unit 362 gives green to the tissue corresponding to the average hardness in the region of interest, gives a blue tone color to the tissue harder than the average, and makes the tissue softer than the average.
- Elastic image data is generated by giving a reddish color.
- the control unit 37 includes a display control unit 371 that controls the display of the display device 4.
- the display control unit 371 controls the display device 4 to display various images generated by the image generation unit 36.
- the control unit 37 is realized by using a general-purpose processor such as a CPU having arithmetic and control functions, or a dedicated integrated circuit such as an ASIC or FPGA.
- a general-purpose processor such as a CPU having arithmetic and control functions
- a dedicated integrated circuit such as an ASIC or FPGA.
- various programs and various data stored in the storage unit 38 are read from the storage unit 38 and various arithmetic processes related to the operation of the ultrasound observation apparatus 3 are executed. To control the ultrasonic observation apparatus 3 in an integrated manner.
- various processes may be executed alone, or various processes may be executed by using various data stored in the storage unit 38.
- control unit 37, the signal processing unit 32, the region-of-interest setting unit 34, the displacement amount calculation unit 35, and the image generation unit 36 are shared by a common general-purpose processor or a dedicated integrated circuit. It is also possible to configure by using.
- the storage unit 38 stores at least temporarily the data of a plurality of ultrasonic images generated by the ultrasonic image generation unit 361, and information on the first ROI set for the ultrasonic image.
- the region-of-interest storage unit 382 stores the displacement amount storage unit 383 that stores the displacement amount calculated by the displacement amount calculation unit 35.
- the number of ultrasonic images stored in the ultrasonic image storage unit 381 is set in advance.
- the displacement amount storage unit 383 stores displacement amount data including a necessary amount when the displacement amount calculation unit 35 calculates the displacement amount.
- the storage unit 38 stores various programs including an operation program for executing the operation method of the ultrasound observation apparatus 3.
- Various programs including the operation program can be recorded on a computer-readable recording medium such as a hard disk, a flash memory, a CD-ROM, a DVD-ROM, or a flexible disk and widely distributed.
- the various programs described above can also be obtained by downloading via a communication network.
- the communication network here is realized by, for example, an existing public line network, LAN (Local Area Network), WAN (Wide Area Network), etc., and may be wired or wireless.
- the storage unit 38 is realized by using a ROM (Read Only Memory) in which various programs are installed in advance, and a RAM (Random Access Memory) in which operation parameters and data for various processes are stored.
- ROM Read Only Memory
- RAM Random Access Memory
- the display device 4 is configured using liquid crystal or organic EL (Electro Luminescence), and receives image data such as an ultrasonic image and an elasticity image generated by the ultrasonic observation device 3 and displays those images. .
- image data such as an ultrasonic image and an elasticity image generated by the ultrasonic observation device 3 and displays those images.
- FIG. 2 is a flowchart showing an outline of processing performed by the ultrasound observation apparatus 3.
- the transmission / reception unit 31 starts transmission of a transmission drive wave signal
- the ultrasonic transducer 21 starts transmission of ultrasonic waves. The process when the setting of the 1st ROI in a sound wave image is completed is shown.
- the transmission / reception unit 31 receives an echo signal that is a measurement result of an observation target by the ultrasonic transducer 21 from the ultrasonic endoscope 2 (step S1).
- the signal processing unit 32 generates reception data by performing a predetermined reception process on the echo signal received from the ultrasonic transducer 21 (step S2). Specifically, the transmission / reception unit 31 amplifies the echo signal (STC correction) and then performs processing such as filtering and A / D conversion.
- the ultrasonic image generation unit 361 generates ultrasonic image data using the reception data generated by the signal processing unit 32 and stores the data in the ultrasonic image storage unit 381, and also controls the display control unit 371. Originally, the data is output to the display device 4 (step S3).
- the displacement amount calculation unit 35 calculates the displacement amount at the observation point in the first ROI stored in the region-of-interest storage unit 382 (step S4). At this time, the displacement amount calculation unit 35 calculates the displacement amount at each observation point by using the latest ultrasonic image data and the past ultrasonic image data stored in the ultrasonic image storage unit 381.
- FIG. 3 is a diagram showing a display example of the first ROI elasticity image on the display device 4.
- the elastic image 100 shown in the figure displays the hardness of each tissue inside the first ROI 101 as an image so as to be identifiable by color. In FIG. 3, the difference in color is schematically represented by a pattern.
- a color scale 102 indicating the color used in the elastic image 100 is displayed. For example, the color scale 102 corresponds to a state where the upper color is harder.
- the region 111 is a region having an average displacement.
- the region 121 is a relatively softest region, and the region 131 is a relatively hardest region.
- the display device 4 displays the elastic image 100 along with the B-mode image. Note that the display device 4 may display the elastic image 100 superimposed on the B-mode image.
- the image generation unit 36 generates image data in which the elastic image 100 is superimposed on the B-mode image, and outputs the image data to the display device 4 under the control of the display control unit 371.
- the region-of-interest setting unit 34 extracts a region having a displacement amount equal to or less than a threshold value in the first ROI (step S6).
- the threshold value in this case is set as a value whose displacement is relatively smaller by a predetermined amount than the reference value, for example, based on the average of the displacements in the first ROI. In addition, it is good also considering the average value itself of the displacement amount in 1st ROI as a threshold value. Further, as the reference value, a statistic such as a median value or a mode value of the displacement amount in the first ROI may be applied.
- the region-of-interest setting unit 34 determines whether or not the minimum unit (pixel or block) of the region continues for a predetermined number or more in the extracted region (step S7).
- the predetermined number here is a number corresponding to, for example, a size that allows a user to visually recognize a continuous area on the screen.
- the region-of-interest setting unit 34 refers to the past displacement amount stored in the displacement amount storage unit 383, and the continuous region is determined. It is determined whether or not it is below a threshold value for a predetermined time (step S8).
- the region-of-interest setting unit 34 sets the area as the second ROI (step S9).
- the predetermined time is, for example, a time comparable to the cycle of pulsation in the subject.
- FIG. 4 is a diagram illustrating a display example of the second ROI elasticity image on the display device 4.
- the elasticity image 200 shown in the figure displays the hardness of each tissue inside the second ROI 201 as an image so that it can be identified by color.
- the color difference is schematically expressed by a pattern.
- a region 211 of the elastic image 200 is a region with an average displacement.
- the region 221 is a relatively soft region, and the region 231 is a relatively hardest region.
- the display device 4 displays the elasticity image 200 side by side with the elasticity image 100.
- the display device 4 may display the elastic image 200 superimposed on the B-mode image.
- the image generation unit 36 generates image data in which the elastic image 200 is superimposed on the B-mode image, and outputs the image data to the display device 4 under the control of the display control unit 371.
- the ultrasound observation apparatus 3 ends a series of processes.
- step S7 When the predetermined number or more is not continuous in step S7 (step S7: No), and when the continuous region is not less than the threshold value for a predetermined time in step S8 (step S8: No), the ultrasound observation apparatus 3 is A series of processing ends.
- the ultrasonic observation apparatus 3 performs the processes of steps S1 to S10 each time an echo signal is received while the elastography mode is set.
- a relatively hard second ROI is automatically set in the first ROI while the elastic image of the first ROI is displayed in real time, and the second ROI is automatically set. Since the elastic image is generated, the trouble of setting the second ROI can be saved. Therefore, both the screening and the detailed examination in ultrasonic elastography can be easily performed without taking time and effort.
- the region is set as the second ROI. Even if ultrasonic elastography is performed using the pulsation of a living body, such as an ultrasonic endoscope, the displacement does not change continuously for multiple frames (displacement over time).
- the second ROI can be accurately set as a region where no change occurs.
- FIG. 5 is a diagram illustrating a display example on the display device 4 of the second ROI elasticity image generated by the ultrasound observation apparatus according to the modified example 1-1 of the first embodiment.
- the elastic image 300 shown in the figure displays a region excluding the second ROI 201 ′ from the first ROI 101 and a second ROI 201 ′ corresponding to the excluded region with different color scales in one image. Therefore, in the elasticity image 300, in addition to the color scale 102 for the elasticity image of the first ROI 101, the color scale 301 for the elasticity image of the second ROI 201 ′ is displayed side by side.
- the elasticity image 300 in FIG. 5 observes the same tissue as the elasticity images 100 and 200 shown in FIGS. 3 and 4, respectively. Therefore, the areas 211 ′, 221 ′, and 231 ′ correspond to the areas 211, 221, and 231 shown in FIG. 4, respectively.
- the boundary B between the second ROI 201 ′ and the first ROI 101 is given the same color as the region 121 of FIG. 3 according to the color scale 102 of the first ROI 101.
- the user can easily recognize the boundary between the first ROI 101 and the second ROI 201 ′.
- FIG. 6 is a flowchart showing an overview of processing performed by the ultrasound observation apparatus according to Modification 1-2 of Embodiment 1. Also in the flowchart shown in FIG. 6, after the ultrasonic diagnostic system 1 is set to the elastography mode, the transmission / reception unit 31 starts transmission of the transmission drive wave signal, and the ultrasonic transducer 21 starts transmission of the ultrasonic wave. The process when the setting of the 1st ROI in a sound wave image is completed is shown. The processes in steps S21 to S26 correspond to the processes in steps S1 to S6 described in the first embodiment in order.
- step S27 the region-of-interest setting unit 34 performs contour extraction (edge extraction) processing on the B-mode image (step S27).
- the region-of-interest setting unit 34 extracts a contour by applying a known filter such as Sobel or Laplacian, for example.
- the region-of-interest setting unit 34 sets the closed region with the contour as the boundary as the second ROI (step S29).
- the threshold value here is also set as a value whose displacement amount is relatively smaller by a predetermined amount than the reference value with the average value of the displacement amount in the first ROI as a reference.
- the elastic image generation unit 362 generates the second ROI elastic image data and outputs the data to the display device 4 (step S30).
- step S28 when there is no region whose displacement is equal to or smaller than the threshold value in the region where the contour is extracted (step S28: No), the ultrasound observation apparatus 3 ends the series of processes.
- the contour of the observation target is extracted on the ultrasound image, and the displacement amount of each observation point in the first region of interest is smaller than a predetermined threshold value. Since the closed region having the extracted contour as the boundary is set as the second region of interest, the relatively hard region can be accurately set as the second ROI.
- FIG. 7 is a diagram schematically showing a configuration of an ultrasonic diagnostic system including the ultrasonic observation apparatus according to Embodiment 2 of the present invention.
- An ultrasonic diagnostic system 5 shown in FIG. 1 includes an ultrasonic endoscope 2, an ultrasonic observation device 6, and a display device 4.
- the configuration of the ultrasound diagnostic system 5 other than the ultrasound observation apparatus 6 is the same as the configuration of the ultrasound diagnostic system 1 described in the first embodiment.
- the ultrasonic observation apparatus 6 is different from the ultrasonic observation apparatus 3 described in the first embodiment in the configuration of the image generation unit.
- the image generation unit 61 included in the ultrasonic observation apparatus 6 includes an average image generation unit 611 in addition to the ultrasonic image generation unit 361 and the elastic image generation unit 362.
- the average image generation unit 611 is designated in the average instruction signal when the freeze instruction signal for displaying the still image on the display device 4 is input from the input unit 33 and when the average instruction signal is further input from the input unit 33.
- Average image data is generated by averaging the pixel values of each pixel in a plurality of ultrasonic images made up of the ultrasonic images.
- the input unit 33 accepts a selection input for an image to be subjected to addition averaging. Specifically, when the input unit 33 receives the input of the average instruction signal, the display control unit 371 causes the display device 4 to display a past ultrasonic image that is an object of addition averaging.
- the display control unit 371 may display the ultrasonic images one by one on the display device 4 or may display several ultrasonic images.
- the average image generation unit 611 generates average image data using a plurality of ultrasonic images selected from the ultrasonic images displayed on the display device 4.
- the region-of-interest setting unit 34 sets a second ROI for the average image based on the average image data generated by the average image generation unit 611.
- the elastic image generation unit 362 automatically generates the elastic image data of the second ROI in the average image.
- FIG. 8 is a flowchart showing an outline of processing performed by the ultrasound observation apparatus 6. Also in the flowchart shown in FIG. 8, after the ultrasonic diagnostic system 5 is set to the elastography mode, the transmission / reception unit 31 starts transmission of the transmission drive wave signal, and the ultrasonic transducer 21 starts transmission of the ultrasonic wave. The process when the setting of the 1st ROI in a sound wave image is completed is shown. The processes in steps S41 to S45 sequentially correspond to the processes in steps S1 to S5 described in the first embodiment.
- step S45 when the input unit 33 receives an input of a freeze instruction signal (step S46: Yes), the process proceeds to step S47.
- step S45 when the input unit 33 does not accept the input of the freeze instruction signal (step S46: No), the ultrasound observation apparatus 6 ends the series of processes.
- step S47 when the input unit 33 receives an input of the average instruction signal (step S47: Yes), the image generation unit 36 sets each pixel of the plurality of ultrasonic images including the ultrasonic image designated in the average instruction signal.
- the average image data is generated by averaging the pixel values (step S48).
- the displacement amount calculation unit 35 calculates the displacement amount at each observation point within the first ROI of the average image (step S49).
- the displacement amount calculation unit 35 reads the displacement amount at each observation point in the plurality of ultrasonic images constituting the average image from the displacement amount storage unit 383, and calculates the average displacement amount at each observation point. This average is the amount of displacement at each observation point of the average image.
- the region-of-interest setting unit 34 extracts a region having a displacement amount equal to or less than a threshold value in the first ROI of the average image (step S50).
- This threshold is set as a value whose displacement is relatively smaller by a predetermined amount than the reference value, with the average when the displacement amount at each observation point in the first ROI in the average image is the population.
- the reference value itself may be used as the threshold value. Further, as the reference value, a statistic such as a median value or a mode value may be applied instead of the average.
- the region-of-interest setting unit 34 determines whether or not the minimum unit (pixel or block) of the region is continuous for a predetermined number or more in the extracted region (step S51).
- the predetermined number here is the same as the number described in step S7 of the first embodiment.
- the region-of-interest setting unit 34 sets the region as the second ROI (step S52).
- the ultrasound observation apparatus 6 ends a series of processes.
- the elastic image generation unit 362 After step S52, the elastic image generation unit 362 generates data of the second ROI elastic image (second elastic image) set in the average image, and displays the data under the control of the display control unit 371. The data is output to the device 4 (step S53). After step S53, the ultrasound observation apparatus 6 ends a series of processes.
- the display device 4 displays the average image and the second ROI elastic image side by side. Note that the display device 4 may superimpose and display the average image and the second ROI elasticity image.
- step S47 No
- the region-of-interest setting unit 34 extracts a region where the displacement amount is equal to or less than the threshold value in the first ROI (step S54).
- the threshold here is the same as the threshold in step S6 described in the first embodiment. Thereafter, the ultrasound observation apparatus 6 proceeds to step S51.
- the elastic image generation unit 362 may further generate data of the first ROI elastic image in the average image and output it to the display device 4.
- the display device 4 displays an average image and first and second ROI elastic images.
- the predetermined number of ultrasonic images are displayed. Generating average image data, automatically setting a relatively hard second ROI within the first ROI of the average image, and generating an elastic image for the second ROI, saving the effort of setting the second ROI it can. Therefore, both the screening and the detailed examination in ultrasonic elastography can be easily performed without taking time and effort.
- the region when a region where the displacement amount in the first ROI is smaller than the threshold is spatially continuous, the region is set as the second ROI. Even when ultrasonic elastography is performed using the pulsation of a living body as an observation target, the second ROI can be accurately set as a region where the displacement amount does not change continuously for a plurality of frames.
- FIG. 9 is a flowchart showing an outline of processing performed by the ultrasonic observation apparatus according to the modified example 2-1 of the second embodiment. Also in the flowchart shown in FIG. 9, after the ultrasonic diagnostic system 5 is set to the elastography mode, the transmission / reception unit 31 starts transmission of the transmission drive wave signal, and the ultrasonic transducer 21 starts transmission of the ultrasonic wave. The process when the setting of the 1st ROI in a sound wave image is completed is shown. The processing of steps S61 to S67 sequentially corresponds to the processing of steps S41 to S47 described in the second embodiment.
- step S67 when the input unit 33 receives the input of the average instruction signal (step S67: Yes), the region-of-interest setting unit 34 refers to the displacement amount storage unit 383 and selects the first ROI in the selected ultrasound image. A region in which the displacement amount is equal to or less than the threshold is extracted (step S68). This threshold is set in the same manner as in the second embodiment.
- the region-of-interest setting unit 34 determines the presence / absence of a region equal to or less than the matching threshold in the predetermined number or more of ultrasonic images (step S69). As a result of the determination, if there is a region equal to or less than the matching threshold in the ultrasonic images of a predetermined number or more (step S69: Yes), the region-of-interest setting unit 34 sets the corresponding region as the second ROI (step S70). On the other hand, when there is no region equal to or less than the matching threshold value in the ultrasonic image of a predetermined number or more (step S69: No), the ultrasonic observation apparatus 6 ends a series of processes.
- the average image generation unit 611 After step S70, the average image generation unit 611 generates average image data, and the elastic image generation unit 362 generates and outputs second ROI elastic image data (step S71).
- the generated average image and second ROI elastic image data are output to the display device 4 under the control of the display control unit 371. Thereafter, the ultrasonic observation apparatus 6 ends a series of processes. Note that the processing of the average image generation unit 611 may be performed in parallel with the processing of steps S68 to S70 described above.
- step S67 the case where the input unit 33 does not accept the input of the average instruction signal will be described (step S67: No).
- the region-of-interest setting unit 34 extracts a region where the displacement amount is equal to or less than the threshold value in the first ROI (step S72).
- This threshold is also the same as the threshold in step S6 described in the first embodiment.
- step S72 corresponds to the processing of steps S51 to S53 described in the second embodiment.
- step S75 the ultrasound observation apparatus 6 ends a series of processes.
- the displacement amount at each observation point of each of the plurality of ultrasonic images stored in the displacement amount storage unit is referred to, and the region is a region where the displacement amount is smaller than the threshold value.
- the area is set as the second ROI, so that a relatively hard area can be accurately set as the second ROI.
- the second ROI may be set in a predetermined shape.
- FIG. 10 is a diagram illustrating a display example on the display device 4 of the elastic image of the second ROI having a predetermined shape.
- the second ROI 401 has a shape substantially similar to the shape of the first ROI 101, and the position of the center of gravity is the same as that of the first ROI 101.
- ultrasonic miniature probe for example, a small-diameter ultrasonic miniature probe without an optical system may be applied.
- Ultrasonic miniature probes are usually inserted into the biliary tract, bile duct, pancreatic duct, trachea, bronchi, urethra, ureter, and used to observe surrounding organs (pancreas, lung, prostate, bladder, lymph nodes, etc.).
- an external ultrasonic probe that irradiates ultrasonic waves from the body surface of the subject may be applied.
- the extracorporeal ultrasonic probe is usually used for observing an abdominal organ (liver, gallbladder, bladder), breast (particularly mammary gland), thyroid gland, and the like.
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Abstract
Description
図1は、本発明の実施の形態1に係る超音波観測装置を備えた超音波診断システムの構成を模式的に示す図である。同図に示す超音波診断システム1は、超音波内視鏡2と、超音波観測装置3と、表示装置4とを備える。
図5は、本実施の形態1の変形例1-1に係る超音波観測装置が生成する第2ROIの弾性画像の表示装置4における表示例を示す図である。同図に示す弾性画像300は、第1ROI101から第2ROI201’を除いた領域と該除いた領域に対応する第2ROI201’とを1つの画像の中で異なるカラースケールにより表示している。このため、弾性画像300では、第1ROI101の弾性画像に対するカラースケール102に加えて、第2ROI201’の弾性画像に対するカラースケール301が並べて表示されている。なお、比較の便宜のため、図5における弾性画像300は、図3および図4にそれぞれ示す弾性画像100および200と同じ組織を観測しているものとする。したがって、領域211’、221’、231’は、図4に示す領域211、221、231にそれぞれ対応している。
図6は、本実施の形態1の変形例1-2に係る超音波観測装置が行う処理の概要を示すフローチャートである。図6に示すフローチャートも、超音波診断システム1がエラストグラフィモードに設定され、送受信部31が送信駆動波信号の送信を開始し、超音波振動子21が超音波の送信を開始した後、超音波画像における第1ROIの設定が完了している場合の処理を示している。ステップS21~S26の処理は、実施の形態1で説明したステップS1~S6の処理に順次対応している。
図7は、本発明の実施の形態2に係る超音波観測装置を備えた超音波診断システムの構成を模式的に示す図である。同図に示す超音波診断システム5は、超音波内視鏡2と、超音波観測装置6と、表示装置4とを備える。超音波観測装置6以外の超音波診断システム5の構成は、実施の形態1で説明した超音波診断システム1の構成と同様である。
図9は、本実施の形態2の変形例2-1に係る超音波観測装置が行う処理の概要を示すフローチャートである。図9に示すフローチャートも、超音波診断システム5がエラストグラフィモードに設定され、送受信部31が送信駆動波信号の送信を開始し、超音波振動子21が超音波の送信を開始した後、超音波画像における第1ROIの設定が完了している場合の処理を示している。ステップS61~S67の処理は、実施の形態2で説明したステップS41~S47の処理に順次対応している。
ここまで、本発明を実施するための形態を説明してきたが、本発明は上述した実施の形態1、2によってのみ限定されるべきものではない。例えば、第2ROIを所定の形状で設定してもよい。図10は、所定の形状を有する第2ROIの弾性画像の表示装置4における表示例を示す図である。同図に示す弾性画像400において、第2ROI401は第1ROI101の形状と略相似な形状を有しており、重心の位置が第1ROI101と同じである。
2 超音波内視鏡
3、6 超音波観測装置
4 表示装置
21 超音波振動子
31 送受信部
32 信号処理部
33 入力部
34 関心領域設定部
35 変位量算出部
36、61 画像生成部
37 制御部
38 記憶部
100、200、300、400 弾性画像
101 第1ROI
102、301 カラースケール
201、201’、401 第2ROI
361 超音波画像生成部
362 弾性画像生成部
371 表示制御部
381 超音波画像記憶部
382 関心領域記憶部
383 変位量記憶部
611 平均画像生成部
B 境界部
Claims (12)
- 観測対象へ超音波を送信し、該観測対象で反射された超音波を受信する超音波振動子を備えた超音波プローブが取得した超音波信号に基づいて観測を行う超音波観測装置であって、
前記超音波信号に基づいて超音波画像のデータを生成する超音波画像生成部と、
前記超音波画像内で予め設定される第1の関心領域の中で相対的に硬い第2の関心領域を自動で設定する関心領域設定部と、
前記第1および第2の関心領域の硬さに応じた表示態様をそれぞれ有する第1および第2の弾性画像のデータを生成する弾性画像生成部と、
を備えることを特徴とする超音波観測装置。 - 前記第1および第2の関心領域における前記観測対象の変位量を算出する変位量算出部をさらに備え、
前記関心領域設定部は、
前記変位量算出部の算出結果に基づいて前記第2の関心領域を設定し、
前記弾性画像生成部は、
前記第1および第2の関心領域における前記変位量に応じた表示態様をそれぞれ有する前記第1および第2の弾性画像のデータを生成することを特徴とする請求項1に記載の超音波観測装置。 - 前記関心領域設定部は、
前記第1の関心領域内の各観測点の前記変位量と所定の閾値とを比較して該閾値より前記変位量が小さい領域を前記第2の関心領域として設定することを特徴とする請求項2に記載の超音波観測装置。 - 前記関心領域設定部は、
前記第1の関心領域内の前記変位量が前記閾値よりも小さい領域が空間的に所定数以上連続し、かつ該連続する領域が所定時間継続している場合、該領域を前記第2の関心領域として設定することを特徴とする請求項3に記載の超音波観測装置。 - 前記関心領域設定部は、
前記超音波画像上で前記観測対象が有する輪郭を抽出し、
抽出した前記輪郭の領域内に前記第1の関心領域内の観測点の前記変位量が所定の閾値より小さい領域がある場合、前記輪郭を境界とする閉領域を前記第2の関心領域と設定することを特徴とする請求項2に記載の超音波観測装置。 - 表示装置における表示を静止画とするフリーズ指示信号の入力を受け付けた場合において、複数の超音波画像を加算平均してなる平均画像を生成するアベレージ指示信号の入力を受け付けたとき、前記平均画像のデータを生成する平均画像生成部をさらに備え、
前記関心領域設定部は、
前記平均画像における前記第1の関心領域内の各観測点における前記変位量が所定の閾値より小さい領域を前記第2の関心領域として設定することを特徴とする請求項2に記載の超音波観測装置。 - 前記関心領域設定部は、
前記第1の関心領域内の統計量が前記閾値よりも小さい領域が空間的に所定数以上連続している場合、該領域を前記第2の関心領域として設定することを特徴とする請求項6に記載の超音波観測装置。 - 前記第1の関心領域の各観測点の変位量を記憶する変位量記憶部をさらに備え、
前記関心領域設定部は、
表示装置における表示を静止画とするフリーズ指示信号の入力を受け付けた場合において、複数の超音波画像を加算平均してなる平均画像を生成するアベレージ指示信号の入力を受け付けたとき、前記変位量記憶部が記憶する前記超音波画像の各観測点における前記変位量を参照し、前記変位量が所定の閾値よりも小さい領域であって前記複数の超音波画像のうち所定枚数以上の超音波画像で一致する領域があるとき、該領域を前記第2の関心領域として設定することを特徴とする請求項2に記載の超音波観測装置。 - 前記第1の関心領域から前記第2の関心領域を除いた領域の弾性画像と前記第2の関心領域の弾性画像とを識別可能な表示態様を有する1つの画像として表示装置に表示させる表示制御部をさらに備えたことを特徴とする請求項1に記載の超音波観測装置。
- 前記第1の関心領域の弾性画像と前記第2の関心領域の弾性画像とを並列して表示装置に表示させる表示制御部をさらに備えたことを特徴とする請求項1に記載の超音波観測装置。
- 観測対象へ超音波を送信し、該観測対象で反射された超音波を受信する超音波振動子を備えた超音波プローブが取得した超音波信号に基づいて観測を行う超音波観測装置の作動方法であって、
弾性画像生成部が、前記超音波信号に基づいて生成される超音波画像内で予め設定される第1の関心領域の硬さに応じた表示態様を有する第1の弾性画像のデータを生成する第1の弾性画像生成ステップと、
関心領域設定部が、前記第1の関心領域の中で相対的に硬い第2の関心領域を設定する関心領域設定ステップと、
前記弾性画像生成部が、前記第2の関心領域の硬さに応じた表示態様を有する第2の弾性画像のデータを生成する第2の弾性画像生成ステップと、
を有することを特徴とする超音波観測装置の作動方法。 - 観測対象へ超音波を送信し、該観測対象で反射された超音波を受信する超音波振動子を備えた超音波プローブが取得した超音波信号に基づいて観測を行う超音波観測装置に、
弾性画像生成部が、前記超音波信号に基づいて生成される超音波画像内で予め設定される第1の関心領域の硬さに応じた表示態様を有する第1の弾性画像のデータを生成する第1の弾性画像生成ステップと、
関心領域設定部が、前記第1の関心領域の中で相対的に硬い第2の関心領域を設定する関心領域設定ステップと、
前記弾性画像生成部が、前記第2の関心領域の硬さに応じた表示態様を有する第2の弾性画像のデータを生成する第2の弾性画像生成ステップと、
を実行させることを特徴とする超音波観測装置の作動プログラム。
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CN108366781A (zh) | 2018-08-03 |
US20180289358A1 (en) | 2018-10-11 |
JP6513220B2 (ja) | 2019-05-15 |
EP3391826A1 (en) | 2018-10-24 |
US11071523B2 (en) | 2021-07-27 |
EP3391826A4 (en) | 2019-07-31 |
JPWO2017104627A1 (ja) | 2018-10-04 |
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