WO2014181903A1 - Transducer - Google Patents

Transducer Download PDF

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Publication number
WO2014181903A1
WO2014181903A1 PCT/KR2013/004131 KR2013004131W WO2014181903A1 WO 2014181903 A1 WO2014181903 A1 WO 2014181903A1 KR 2013004131 W KR2013004131 W KR 2013004131W WO 2014181903 A1 WO2014181903 A1 WO 2014181903A1
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WO
WIPO (PCT)
Prior art keywords
zion
transducer
membrane
ultrasonic
frame
Prior art date
Application number
PCT/KR2013/004131
Other languages
French (fr)
Korean (ko)
Inventor
손건호
강국진
김대승
전석환
김종훈
Original Assignee
알피니언메디칼시스템 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 알피니언메디칼시스템 주식회사 filed Critical 알피니언메디칼시스템 주식회사
Priority to PCT/KR2013/004131 priority Critical patent/WO2014181903A1/en
Publication of WO2014181903A1 publication Critical patent/WO2014181903A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H23/00—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms
    • A61H23/02—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms with electric or magnetic drive
    • A61H23/0245—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms with electric or magnetic drive with ultrasonic transducers, e.g. piezoelectric
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01K—MEASURING TEMPERATURE; MEASURING QUANTITY OF HEAT; THERMALLY-SENSITIVE ELEMENTS NOT OTHERWISE PROVIDED FOR
    • G01K11/00—Measuring temperature based upon physical or chemical changes not covered by groups G01K3/00, G01K5/00, G01K7/00 or G01K9/00
    • G01K11/12—Measuring temperature based upon physical or chemical changes not covered by groups G01K3/00, G01K5/00, G01K7/00 or G01K9/00 using changes in colour, translucency or reflectance
    • G01K11/14—Measuring temperature based upon physical or chemical changes not covered by groups G01K3/00, G01K5/00, G01K7/00 or G01K9/00 using changes in colour, translucency or reflectance of inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00773—Sensed parameters
    • A61B2018/00791—Temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00773—Sensed parameters
    • A61B2018/00791—Temperature
    • A61B2018/00809—Temperature measured thermochromatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/50—Control means thereof
    • A61H2201/5058—Sensors or detectors
    • A61H2201/5082—Temperature sensors

Definitions

  • This embodiment relates to a transducer. More specifically, it includes a zion material whose optical properties change due to temperature changes in the contact area with the living body, so that the temperature of the transducer can be quickly and accurately detected during treatment, thereby preventing damage to the surface or skin of the living body. It relates to a transducer that can be safely performed.
  • the High Intensity Focused Ultrasound (hereinafter referred to as HIFU) treatment device utilizes ultrasound as a source of energy and the penetrability and focus of the ultrasound.
  • HIFU is radiated through the skin from a transducer comprising a delivery medium to cancerous tissue in the human body.
  • a transducer comprising a delivery medium to cancerous tissue in the human body.
  • the ultrasound beam is focused within the tissue and is a roughly grain-shaped focal region (approximately 3 mm ⁇ 8 mm) with an intensity level above 0.1 W / cm 2 . Size) is formed.
  • the temperature rises instantaneously (within 0.1 to 5 seconds) (more than 70 degrees Celsius).
  • This thermal effect destroys cancer cells in the focal region and finally necrosis and destroys the entire cancer tissue, thereby realizing the purpose of treatment.
  • an ultrasonic vibrator capable of delivering an ultrasound beam of 1,000 to 10,000 W / cm 2 to the focal region is used. Some energy of HIFU generated from this ultrasonic vibrator is transferred to the target area as thermal energy. The amount of thermal energy delivered in this way can be supplied sufficiently strong to cauterize or necrosis the undesirable tissue by causing the tissue to rise to a temperature above 70 degrees Celsius without actually burning it. Further, the focal region can be strictly controlled to obtain necrosis of abnormal tissue or undesirable tissue of a small target region without damaging adjacent normal tissue.
  • Necrosis of tissue can also be achieved by mechanical action alone (ie, by the formation of cavities that lead to mechanical destruction of the tissue structure).
  • hemostasis may be performed using HIFU.
  • HIFU treatment is non-invasive.
  • HIFU can destroy cancer in the heart without surgery on the cancer site.
  • HIFU can provide additional methods of treatment that do not contradict this tendency by providing noninvasive surgical methods.
  • HIFU allows for transcutaneous treatment without incision, thereby avoiding blood loss and risk of infection.
  • HIFU treatment does not require anesthesia, reducing the complexity and cost of surgery.
  • Such HIFU treatment may be performed on hospital patients, and the greatest advantage is that the health care costs are further reduced while the convenience of the patients is improved.
  • the transducer provided in the treatment apparatus using the HIFU generates the HIFU, which is the physical vibration energy, by the ultrasonic vibrator under the control of the control device, and irradiates the HIFU to the treatment area inside the human body to be treated.
  • the transducer can be positioned in close proximity to the treatment area through manual positioning by the operator or automatic positioning via robotic arm mechanisms.
  • the HIFU can be output from the transducer to a treatment area of about tens to hundreds of watts.
  • a treatment area of about tens to hundreds of watts.
  • the treatment area is heated to a high temperature (eg, 70 degrees Celsius or more), which is cauterized and treatment is performed.
  • FIG. 1 is a partial cross-sectional view of an example of a transducer used in the aforementioned HIFU treatment devices.
  • Transducer 100 shown here includes a substantially hemispherical frame 101 and at least one ultrasonic vibrator 102 attached to the frame 101 to irradiate ultrasonic waves.
  • the transducer 100 has a substantially hemispherical membrane 103 having a sealing device 104 formed at its end to be connected to the frame 101 to be hermetically sealed. The membrane 103 covers and closes the ultrasonic vibrator 102.
  • the ultrasonic delivery medium is filled between the membrane 103 and the ultrasonic vibrator 102.
  • Unexplained reference numeral 105 denotes a push ring for connecting the membrane 103 to the frame 101.
  • an imaging probe 120 connected to an ultrasound imaging apparatus (not shown) and collecting image data may be installed in the transducer 100.
  • the ultrasonic delivery medium may be water deaired.
  • One of the important components of all types of HIFU treatment devices is the means of coupling ultrasound energy into tissue. Good acoustic coupling is required to efficiently transfer ultrasonic energy from the ultrasonic vibrator 102 to the treatment area.
  • An ideal acoustic coupler is a homogenous medium with the same low attenuation and acoustic impedance as the tissue. Water has been commonly used as ultrasonic delivery medium in many HIFU therapeutic fields for desirable acoustic transmission properties.
  • Membrane 103 is made of a material having a sound impedance similar to water, low ultrasonic transmission loss, perfect thermal conductivity, and good elasticity.
  • the transducer 100 may be made by concave processing of the ultrasonic vibrator 102 using a focal length as a radius for physical focusing of ultrasonic energy.
  • the transducer 100 may be made by attaching an ultrasonic vibrator 102 in the form of tens or hundreds of disks or polygonal plates to a concave frame 101 having a radius of focal length.
  • the part when attempting to heat the living body using HIFU, if a material that is clearly different from the living body, such as air bubbles, exists in the portion where the transducer and the surface are coupled, for example, the part generates heat and damages the surface of the living body. There is a risk of making. In addition, the same heat generation may occur depending on the difference in the stratum corneum existing on the surface of the living body and the acoustic characteristics inside the living body.
  • thermometers such as a platinum resistance thermometer, a thermocouple thermometer, and a thermistor thermometer
  • non-contact thermometers such as a radiation thermometer, an infrared thermometer, and a thermal imaging camera.
  • thermometer In the measurement during heating using HIFU, it is difficult to contact metallic thermometers with different acoustic characteristics on the surface of the living body, and the thermometer cannot be placed at the coupling site of the living body surface, so that the contact thermometer is not preferable.
  • the non-contact thermometer detects radiation energy such as light or heat emitted from an object under high temperature and detects temperature by using a constant relationship between temperature and energy, such as inaccuracy of emissivity or absorption or scattering in an optical path.
  • radiation energy such as light or heat emitted from an object under high temperature
  • detects temperature by using a constant relationship between temperature and energy, such as inaccuracy of emissivity or absorption or scattering in an optical path.
  • an error occurs and it is difficult to accurately measure the temperature at the coupling site of the living body surface.
  • thermometers or cameras there is also a problem in that the number of parts and the cost of installing the related parts are increased.
  • the present embodiment provides a transducer capable of safely carrying out the treatment by quickly and accurately determining the temperature of the transducer without interrupting the delivery of ultrasound during treatment, thereby preventing damage to the surface or skin of the living body.
  • a transducer capable of safely carrying out the treatment by quickly and accurately determining the temperature of the transducer without interrupting the delivery of ultrasound during treatment, thereby preventing damage to the surface or skin of the living body.
  • the frame At least one ultrasonic vibrator attached to the frame to irradiate ultrasonic waves; And a membrane mounted to the frame to cover a part of the frame and the ultrasonic vibrator to receive the ultrasonic transmission medium therein, wherein the membrane contains a Zion material, and the optical properties change according to temperature changes. do.
  • the frame At least one ultrasonic vibrator attached to the frame to irradiate ultrasonic waves; And a membrane mounted to the frame to cover a part of the frame and the ultrasonic vibrator to receive the ultrasonic transfer medium therein, wherein the ultrasonic transfer medium contains a Zion material and changes optical characteristics according to temperature change. It features.
  • a Zion material whose optical properties change due to a temperature change in a contact portion or a close contact with a living body, and quickly and accurately grasp the temperature of the transducer without disturbing the transmission of ultrasound during treatment This prevents damage to the surface of the living body or skin in advance, thereby enabling the treatment to be safely performed.
  • FIG. 1 is a partial cross-sectional view of an example of a transducer used in prior art HIFU treatment devices.
  • FIG. 2 is a partial cross-sectional view of a transducer according to an embodiment.
  • FIG. 3 is a partial cross-sectional view of a transducer according to another embodiment.
  • the transducer 200 includes a frame 101; At least one ultrasonic vibrator 102 attached to the frame 101 to irradiate ultrasonic waves; A membrane 203 is mounted on the frame 101 to cover a part of the frame 101 and the ultrasonic vibrator 102 to receive the ultrasonic transmission medium 201 therein, and the membrane 203 is a Zion material. It contains and the optical properties change with the temperature change.
  • the frame 101 may be composed of various heat sinks.
  • it may be formed of a member made of metal such as aluminum, but the material of the frame 101 is not limited thereto.
  • a substantially hemispherical concave frame 101 is illustrated in the drawings, a plurality of ultrasonic vibrators 102 may be inserted into and installed on the flat disc of the frame 101. That is, the shape of the frame 101 may be formed in various shapes that can be in contact with the surface of the living body, provided that the treatment with the ultrasonic vibrator 102 to be described later to allow treatment.
  • the ultrasonic vibrator 102 has an ultrasonic radiating surface suitably formed according to the shape of the frame 101 to cover the surface of the frame 101 with a single ultrasonic vibrator, or dozens or hundreds of ultrasonic vibrators form a disc or a polygonal flat plate. It may be formed to be attached to the frame 101.
  • the latter transducer is called a so-called array transducer, and by utilizing this, the ultrasonic focusing position can be varied by inputting an electrical signal having a different phase to each of the attached ultrasonic transducers. That is, the arrayed transducer can vary a single focal point or generate multiple focal points by electric steering alone. Therefore, since the mechanical movement of the transducer is not required to treat a wide range of areas, the treatment system is simplified and the treatment time can be shortened.
  • the arrayed transducer may include one or more acoustic matching layers positioned on one side of the ultrasonic vibrator 102 to appropriately form resonance characteristics.
  • a signal line may be connected to deliver an electrical signal to the ultrasonic vibrator 102.
  • the ultrasonic vibrator 102 may be made of piezoelectric materials such as piezoelectric ceramics, crystals, composite materials, etc., for example, PZT (Lead Zirconate Titanate), while the signal lines may be configured in the form of wires, which may be arranged and connected in various ways. The detailed description thereof will be omitted here.
  • the ultrasonic delivery medium 201 is filled between the membrane 203 and the ultrasonic radiating surface of the ultrasonic vibrator 102.
  • Unexplained reference numeral 105 denotes a push ring for connecting the membrane 203 to the frame 101.
  • an imaging probe 120 connected to an ultrasound imaging apparatus (not shown) and collecting image data may be installed in the transducer 200.
  • the ultrasonic delivery medium 201 may be water from which air is removed. As noted above, water is commonly used as the ultrasound delivery medium in many therapeutic applications for desirable acoustic transmission or cooling.
  • the membrane 203 has a sound impedance similar to water and is made of a material having low ultrasonic wave transmission loss, perfect thermal conductivity, and good elasticity such as latex, relatively soft natural rubber, silicone rubber, urethane resin, and the like.
  • the surface of the membrane 203 is a site in contact with or in proximity to the biological surface. If the surface temperature of the membrane 203 rises excessively, it may adversely affect the surface of the living body and, in severe cases, burns.
  • the temperature at the surface of the membrane 203 and its distribution vary depending on the difference in the materials used, the difference in the arrangement of the ultrasonic vibrators, and the like.
  • the actual temperature of the membrane 203 changes not only in these conditions but also in the use environment. For example, the external temperature, the body temperature of the living body, the duration of use, the presence or absence of a gel, and the contact position of the membrane 203. And the like.
  • the membrane 203 which is in direct contact with or in close proximity to the surface of the living body is included with the zion material whose optical properties change with temperature.
  • a Zion material whose optical properties change with temperature changes is mixed with the material of the Membrane 203 and the membrane ( 203).
  • Zion pigments are powdered Zion pigments or when the products are formed using the Zion pigments, the pigments are processed into microcapsules to protect the powdered pigments from heat and improve dispersion, and 12 to 18% of Zion pigments therein. Zion pigments in the form of Master Batch may be used.
  • Zion pigments use reversible types that are converted to color when the temperature returns to their original state.
  • the principles of color development are solid phase reaction, pyrolysis, dehydration, electron transfer of electron donor or acceptor, The change in crystal structure is used.
  • the reversible Zion pigment has a reference temperature of -15 ° C to 70 ° C.
  • a single pigment that discolors in a temperature range of 40 ° C to 45 ° C may be used.
  • the present invention is not necessarily limited thereto.
  • the reaction temperature range of the Zion pigment is divided by 10 ° C., and three types of Zion pigments are formed to color the temperature. It can be expressed as There are 15 kinds of colors of Zion pigment, but usually black, blue, red and yellow are used, and the remaining colors are realized by mixing general ink or pigment.
  • the first Zion pigment which changes color from yellow to transparent at around 35 ° C, and the second color changing from red to transparent at about 45 ° C It is good to combine Zion pigment, the 3rd Zion pigment which discolors from blue to transparent near 55 degreeC, and the ground color pigment which expresses red by a basic color. By combining these ground color pigments and three kinds of Zion pigments, a material which changes color from black to red with a temperature change between 30 to 60 ° C is obtained.
  • a combination of Zion Pigment and General Background Pigment is used to show the mixed color when the temperature does not rise, and when the temperature is raised, the color of Zion Pigment is changed to transparent and only the color of the background pigment is displayed. It is good to be able to pay. However, when determining the color, it is necessary to pay attention to the color of the background color pigment. If the color of the background color pigment is dark and the Zion pigment is bright, the background color may be revealed due to the hiding power.
  • an irreversible type of Zion pigment can be used, but this irreversible type is a one-time reversal which does not return to the original color, and has a temperature range of 40 to 450 ° C.
  • the zion material is prepared by mixing the membrane 203 as described above, the color of the membrane 203 is changed according to the temperature of the membrane 203 itself, and thus the membrane 203 and the living body are more accurately compared to the conventional one.
  • the temperature of the surface can be grasped quickly, accurately and easily with the naked eye through the color of the membrane 203.
  • the whole membrane 203 shows temperature, temperature distribution etc. can also be grasped reliably.
  • the identification of these changes in temperature allows the treatment to be controlled, ultimately preventing burns on the surface of the living body or skin and safely performing the treatment.
  • the zion material that changes color depending on the temperature is mixed with the material of the membrane 203, there is a difference from the technique using a conventional thermometer or a temperature sensor, and does not interfere with the transmission of ultrasonic waves.
  • the example which mixed the Zion material with the material of the membrane 203 is described, you may adhere
  • a thin film formed of a material in which a Zion material is mixed is produced, and the film is adhered to the surface of the membrane 203.
  • a liquid containing Zion material may be applied to the surface of the membrane 203.
  • the Zion part may be easily formed in the existing transducer (eg, 100) that does not contain the Zion material.
  • the HIFU transducer 300 includes a frame 101; At least one ultrasonic vibrator 102 attached to the frame 101 to irradiate ultrasonic waves; A membrane 303 is mounted on the frame 101 to cover a part of the frame 101 and the ultrasonic vibrator 102 to receive the ultrasonic transfer medium 301 therein, and the ultrasonic transfer medium 301 is Zion. It contains a substance that changes its optical properties with temperature changes.
  • the transducer 300 according to the second embodiment has a configuration and operation except that Zion material is included in the ultrasonic transfer medium 301 instead of the membrane 203 of the transducer 200 according to the first embodiment. Since it is the same as the transducer 200 according to the first embodiment, in describing the transducer 300 according to the second embodiment, the same components as those of the transducer 200 according to the first embodiment will be described. The same reference numerals will be used to omit the detailed description of the structure and function.
  • the ultrasonic transfer medium 301 may be water from which air is removed.
  • the ultrasonic delivery medium 301 that is, water that is close to the surface of the living body, includes a zion material whose optical properties change with temperature.
  • Zion pigments which has high precision of discoloration, and has high freedom of selection of a color species and discoloration temperature.
  • Zion pigments are used as Zion pigments in the form of aqueous slurries, and reversible types are used that revert when the temperature returns to the original state.
  • aqueous slurries are in the form of a liquid so as to mix well with an aqueous ink or an aqueous solution, and are dispersed in water smoothly.
  • Reversible Zion pigments have a reference temperature of generally -15 ° C to 70 ° C.
  • a single pigment that discolors in a temperature range of 40 ° C to 45 ° C may be used.
  • the present invention is not necessarily limited thereto, and two or more types of Zion pigments may be combined to express temperature in color.
  • a combination of Zion Pigment and General Ink shows a mixed color when the temperature is not raised, and when the temperature is raised, the Zion Pigment is changed to a transparent color. have.
  • the membrane 303 has a sound impedance similar to that of water, and is made of a material having low ultrasonic transmission loss, perfect thermal conductivity, and good elasticity. At this time, the membrane 303 is preferably visually transparent or translucent. However, it is not necessarily limited thereto.
  • the color of the ultrasonic delivery medium 301 is changed according to the temperature of the ultrasonic delivery medium 301 itself, and due to the color change, the membrane 303 ) Will also appear to change color. Accordingly, the temperature of the ultrasonic delivery medium 301 or the membrane 303 and the surface of the living body can be quickly and accurately identified with the naked eye through the color of the ultrasonic delivery medium 301 as compared with the conventional art. The identification of such temperature changes allows the treatment to be controlled, ultimately preventing burns on the surface of the living body or skin and safely performing the treatment. In addition, since the Zion material that changes color depending on the temperature is contained in the ultrasonic transmission medium 301, there is a difference from the conventional technique using a thermometer or a temperature sensor, and does not interfere with the transmission of ultrasonic waves.
  • the membrane 203 and the membrane 203 of the transducer 200 according to the first embodiment may be used. Since there is no need for a process such as curing or molding after mixing, there is an advantage that it is much easier to configure and manufacture than the transducer 200 according to the first embodiment.

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Abstract

An embodiment of the present invention relates to a transducer comprising heat-sensitive material, in or near the area of contact with the body, the optical characteristics of which vary according to temperature changes, thereby allowing rapid and accurate examination of the temperature of the transducer without interfering with the ultrasound transmission during treatment, and thus a treatment can be safely administered by preventing damage from happening to a biosurface or the skin.

Description

트랜스듀서Transducer
본 실시예는 트랜스듀서에 관한 것이다. 더욱 상세하게는 생체와의 접촉 부분에 온도 변화로 광학 특성이 변화하는 시온물질을 포함하여서, 치료시 트랜스듀서의 온도를 신속하고 정확히 파악하게 되어 생체 표면 또는 피부의 손상을 미연에 방지함으로써 치료를 안전하게 수행할 수 있는 트랜스듀서에 관한 것이다.This embodiment relates to a transducer. More specifically, it includes a zion material whose optical properties change due to temperature changes in the contact area with the living body, so that the temperature of the transducer can be quickly and accurately detected during treatment, thereby preventing damage to the surface or skin of the living body. It relates to a transducer that can be safely performed.
이하에 기술되는 내용은 단순히 본 실시예와 관련되는 배경정보만을 제공할 뿐 종래기술을 구성하는 것이 아님을 밝혀둔다. It should be noted that the contents described below merely provide background information related to the present embodiment and do not constitute a prior art.
근래에, 의학 연구자들은 암 세포의 열 저항이 정상 세포보다 뒤떨어진다는 점을 발견하였다. 즉, 온도가 섭씨 42.5 도를 상회할 때 정상 세포는 약간 손상되고 그 손상된 세포는 재생될 수 있지만, 암 세포는 30 분 이내에 소멸한다. 이러한 특성에 따라 고강도 집속 초음파(High Intensity Focused Ultrasound; 이하 HIFU라 함) 치료장치는 에너지의 원천으로서 초음파 그리고 이 초음파의 관통성 및 집속성을 이용한다. In recent years, medical researchers have found that the heat resistance of cancer cells lags behind normal cells. That is, when the temperature is above 42.5 degrees Celsius, normal cells are slightly damaged and the damaged cells can be regenerated, but cancer cells die out within 30 minutes. According to these characteristics, the High Intensity Focused Ultrasound (hereinafter referred to as HIFU) treatment device utilizes ultrasound as a source of energy and the penetrability and focus of the ultrasound.
HIFU 치료장치의 한 예에서는, 전달매질을 포함하는 트랜스듀서로부터 피부를 통하여 HIFU를 인체 내의 암 조직으로 방사한다. 비교적 낮은 레벨(Level)의 초음파를 전달하면, 조직 내에서 초음파 빔(Beam)은 초점이 맞추어지고, 0.1 W/cm2를 넘는 강도 레벨을 가진 대략 쌀알 모양의 초점영역(약 3 mm × 8 mm 크기)이 형성된다. 이 초점영역에서 온도는 순간(0.1 내지 5 초 이내)적으로 급상승(섭씨 70 도 이상)한다. In one example of a HIFU treatment device, HIFU is radiated through the skin from a transducer comprising a delivery medium to cancerous tissue in the human body. By delivering a relatively low level of ultrasound, the ultrasound beam is focused within the tissue and is a roughly grain-shaped focal region (approximately 3 mm × 8 mm) with an intensity level above 0.1 W / cm 2 . Size) is formed. In this focal region, the temperature rises instantaneously (within 0.1 to 5 seconds) (more than 70 degrees Celsius).
이 열적 효과에 의해, 초점영역에서 암 세포를 파괴하고 최종적으로 암 조직 전체를 괴사 소멸시켜 치료의 목적이 실현된다.This thermal effect destroys cancer cells in the focal region and finally necrosis and destroys the entire cancer tissue, thereby realizing the purpose of treatment.
통상 HIFU 치료에서는, 강도 레벨이 0.1 W/cm2 보다 낮은 진단용 영상 초음파와는 대조적으로, 1,000 ∼ 10,000 W/cm2의 초음파 빔을 초점영역에 전달할 수 있는 초음파 진동자를 사용한다. 이 초음파 진동자로부터 발생한 HIFU의 일부 에너지가 열 에너지로 대상 영역에 전달된다. 이처럼 전달되는 열 에너지량은, 조직을 실제 물리적으로 태우지 않고 섭씨 70 도 이상의 온도로 상승하게 함으로써 바람직하지 못한 조직을 소작(燒灼)하거나 괴사시킬 정도로 충분히 강하게 공급할 수 있다. 또, 인접한 정상적인 조직을 손상시키지 않으면서 작은 대상 영역의 이상 조직 또는 바람직하지 못한 조직의 괴사를 얻도록 초점영역을 엄밀하게 제어할 수 있다.In conventional HIFU treatment, in contrast to diagnostic imaging ultrasound having an intensity level lower than 0.1 W / cm 2 , an ultrasonic vibrator capable of delivering an ultrasound beam of 1,000 to 10,000 W / cm 2 to the focal region is used. Some energy of HIFU generated from this ultrasonic vibrator is transferred to the target area as thermal energy. The amount of thermal energy delivered in this way can be supplied sufficiently strong to cauterize or necrosis the undesirable tissue by causing the tissue to rise to a temperature above 70 degrees Celsius without actually burning it. Further, the focal region can be strictly controlled to obtain necrosis of abnormal tissue or undesirable tissue of a small target region without damaging adjacent normal tissue.
조직의 괴사는 기계적 행위만으로(즉, 조직 구조의 기계적 파괴를 가져오는 공동(空洞, Cavitation) 형성에 따라) 달성할 수도 있다. 또한, 혈액을 내부 구조에 공급하는 심장계가 치료의 대상인 경우, HIFU를 사용하여 지혈할 수도 있다. Necrosis of tissue can also be achieved by mechanical action alone (ie, by the formation of cavities that lead to mechanical destruction of the tissue structure). In addition, if the cardiac system that supplies blood to the internal structure is the subject of treatment, hemostasis may be performed using HIFU.
기존의 치료에 비해 HIFU 치료가 갖는 우수한 특징은 HIFU 치료가 비침습성(Non-invasive)이라는 점이다. 한 예로, 암 부위를 수술하지 않고 HIFU로 심부에 있는 암을 파괴할 수 있다. An excellent feature of HIFU treatment compared to conventional treatment is that HIFU treatment is non-invasive. For example, HIFU can destroy cancer in the heart without surgery on the cancer site.
의학적 치료의 현재의 방향은, 복강경 및 내시경 기법의 사용이 증대하고 있는 것으로부터 분명히 알 수 있듯이, 점진적으로 비침습성 및 비수술식의 방법을 사용하는 방향으로 발전하고 있다. 이의 장점은, 혈액 손실의 감소, 감염 위험성의 감소, 더욱 짧은 입원일수, 및 더욱 저렴한 건강 관리 비용 등이 있다. The current direction of medical treatment is evolving toward the use of progressively non-invasive and non-surgical methods, as is evident from the increasing use of laparoscopic and endoscopic techniques. Advantages include reduced blood loss, reduced risk of infection, shorter hospitalization days, and lower health care costs.
HIFU는 비침습성 수술 방법을 제공함으로써, 이러한 경향과 모순되지 않는 추가의 치료 방법을 제공할 수 있다. HIFU는 절개하지 않고 피부를 통한 치료(Transcutaneous Treatment)를 가능하게 하며, 이로써 혈액의 손실 및 감염의 위험을 피할 수 있다. 또한, HIFU 치료는 마취할 필요가 없어서 수술의 복잡함 및 비용을 감소시킨다. 이러한 HIFU 치료는, 통원 환자에 대하여 시술할 수도 있으며, 건강 관리 비용을 더욱 감소시키는 한편, 환자의 편의성을 향상시킨다는 점이 가장 큰 장점이다. HIFU can provide additional methods of treatment that do not contradict this tendency by providing noninvasive surgical methods. HIFU allows for transcutaneous treatment without incision, thereby avoiding blood loss and risk of infection. In addition, HIFU treatment does not require anesthesia, reducing the complexity and cost of surgery. Such HIFU treatment may be performed on hospital patients, and the greatest advantage is that the health care costs are further reduced while the convenience of the patients is improved.
이러한 HIFU를 이용한 치료장치에 구비되는 트랜스듀서는, 제어장치의 제어 하에서 초음파 진동자에 의해 물리적 진동에너지인 HIFU가 발생하여 치료대상인 인체의 내부에 있는 치료영역에 대해 HIFU를 조사(照射)한다. 트랜스듀서는 시술자에 의한 수동의 위치 조정 또는 로보틱 아암 기구(Robotic Arm Mechanism)를 매개로 한 자동 위치 조정을 통하여 치료영역에 근접하게 위치될 수 있다. The transducer provided in the treatment apparatus using the HIFU generates the HIFU, which is the physical vibration energy, by the ultrasonic vibrator under the control of the control device, and irradiates the HIFU to the treatment area inside the human body to be treated. The transducer can be positioned in close proximity to the treatment area through manual positioning by the operator or automatic positioning via robotic arm mechanisms.
트랜스듀서를 구비한 HIFU 치료장치를 이용하여, 예를 들면 인체에 대하여 HIFU의 발열 작용을 이용한 치료를 행하는 경우에, 트랜스듀서로부터 치료영역에 대하여 HIFU를 수십에서 수백 와트(Watt) 정도의 출력으로 수 초에서 수십 초간 연속하여 조사함으로써, 치료영역을 고온(예컨대, 섭씨 70 도 이상)으로 가열되게 하고, 이를 소작하여 치료가 이루어진다. Using a HIFU treatment device equipped with a transducer, for example, when a human body uses the heat exerted by the HIFU, the HIFU can be output from the transducer to a treatment area of about tens to hundreds of watts. By continuously irradiating for a few seconds to several tens of seconds, the treatment area is heated to a high temperature (eg, 70 degrees Celsius or more), which is cauterized and treatment is performed.
도 1은 전술한 HIFU 치료장치들에 사용되는 트랜스듀서의 한 예를 부분적으로 도시한 단면도이다. 1 is a partial cross-sectional view of an example of a transducer used in the aforementioned HIFU treatment devices.
이에 도시된 트랜스듀서(100)는 대략 반구 형상의 프레임(101)과, 이 프레임(101)에 부착되어 초음파를 조사하는 적어도 하나의 초음파 진동자(102)를 구비한다. 또한, 트랜스듀서(100)는 프레임(101)에 밀폐되도록 연결되기 위해 단부에 밀폐장치(104)가 형성된 대략 반구 형상의 멤브레인(103)을 구비한다. 이 멤브레인(103)은 초음파 진동자(102)를 씌우면서 이를 폐쇄한다. Transducer 100 shown here includes a substantially hemispherical frame 101 and at least one ultrasonic vibrator 102 attached to the frame 101 to irradiate ultrasonic waves. In addition, the transducer 100 has a substantially hemispherical membrane 103 having a sealing device 104 formed at its end to be connected to the frame 101 to be hermetically sealed. The membrane 103 covers and closes the ultrasonic vibrator 102.
초음파 전달매질은 멤브레인(103)과 초음파 진동자(102) 사이에 채워진다. 미설명된 참조부호 105는 멤브레인(103)을 프레임(101)에 연결하기 위한 누름링을 표시한다. 추가로, 초음파 영상장치(미도시)에 연결되고 영상 데이터를 수집하는 이미징용 프로브(120)가 트랜스듀서(100) 내에 설치될 수 있다. The ultrasonic delivery medium is filled between the membrane 103 and the ultrasonic vibrator 102. Unexplained reference numeral 105 denotes a push ring for connecting the membrane 103 to the frame 101. In addition, an imaging probe 120 connected to an ultrasound imaging apparatus (not shown) and collecting image data may be installed in the transducer 100.
초음파 전달매질은 공기가 제거된 물일 수 있다. 모든 유형의 HIFU 치료장치의 중요한 구성요소 중 하나는 초음파 에너지를 조직 내에 커플링하는 수단이다. 초음파 진동자(102)로부터 치료영역에 초음파 에너지를 효율적으로 전달하기 위해서는 양호한 음향 커플링이 필요하다. 이상적인 음향 커플러(Acoustic Coupler)는 조직과 동일한 낮은 감쇠 및 음향 임피던스를 가지는 동질 매체이다. 바람직한 음향 투과 특성을 위해 많은 HIFU 치료 분야에서는 물이 초음파 전달매질로서 통상 사용되어 왔다.The ultrasonic delivery medium may be water deaired. One of the important components of all types of HIFU treatment devices is the means of coupling ultrasound energy into tissue. Good acoustic coupling is required to efficiently transfer ultrasonic energy from the ultrasonic vibrator 102 to the treatment area. An ideal acoustic coupler is a homogenous medium with the same low attenuation and acoustic impedance as the tissue. Water has been commonly used as ultrasonic delivery medium in many HIFU therapeutic fields for desirable acoustic transmission properties.
멤브레인(103)은 물과 유사한 음향 임피던스를 갖고, 적은 초음파 전달손실, 완벽한 열전도율, 그리고 좋은 탄성을 가진 물질로 제조된다. Membrane 103 is made of a material having a sound impedance similar to water, low ultrasonic transmission loss, perfect thermal conductivity, and good elasticity.
트랜스듀서(100)는 초음파 에너지의 물리적 집속을 위해 초점거리를 반경으로 하여 초음파 진동자(102)를 오목하게 가공하여 만들어질 수 있다. 혹은, 트랜스듀서(100)는 수십 내지 수백 개의 원판이나 다각형 평판 형태의 초음파 진동자(102)를 초점거리를 반경으로 하는 오목한 형태의 프레임(101)에 부착하여 만들어질 수 있다. The transducer 100 may be made by concave processing of the ultrasonic vibrator 102 using a focal length as a radius for physical focusing of ultrasonic energy. Alternatively, the transducer 100 may be made by attaching an ultrasonic vibrator 102 in the form of tens or hundreds of disks or polygonal plates to a concave frame 101 having a radius of focal length.
그런데 HIFU를 이용하여 생체 내를 가열하려고 할 때, 트랜스듀서와 생체 표면의 커플링 되는 부위에 예컨대 기포 등과 같이 음향 특성이 생체와 분명히 다른 물질이 존재하게 되면, 그 부분이 발열하여 생체 표면을 손상시킬 우려가 있다. 또, 생체 표면에 존재하는 각질층과 생체 내부의 음향 특성의 차이에 따라서도 마찬가지의 발열이 일어날 수 있다. However, when attempting to heat the living body using HIFU, if a material that is clearly different from the living body, such as air bubbles, exists in the portion where the transducer and the surface are coupled, for example, the part generates heat and damages the surface of the living body. There is a risk of making. In addition, the same heat generation may occur depending on the difference in the stratum corneum existing on the surface of the living body and the acoustic characteristics inside the living body.
이에 따라 발열에 의한 생체 표면의 손상, 즉 화상을 미연에 방지하기 위해, 생체 표면의 온도 변화를 항상 관측하고, 비정상적인 발열이 나타나는 경우에 HIFU의 조사를 약하게 하거나 정지시킬 수 있는 다양한 방안이 제안되어 있다. Accordingly, in order to prevent damage to the surface of the living body due to heat generation, that is, burns, various measures have been proposed to always observe the temperature change on the surface of the living body and to weaken or stop the HIFU irradiation when abnormal heat is generated. have.
통상 생체 표면의 온도 변화를 측정하기 위해서는, 백금측온 저항체 온도계, 열전대 온도계, 서미스터(Thermistor) 온도계 등의 접촉형 온도계와, 방사 온도계, 적외선 온도계, 열화상 카메라 등의 비접촉형 온도계를 사용하는 것이 생각될 수 있다. In order to measure the temperature change of the surface of a living body, it is generally thought to use contact type thermometers, such as a platinum resistance thermometer, a thermocouple thermometer, and a thermistor thermometer, and non-contact thermometers, such as a radiation thermometer, an infrared thermometer, and a thermal imaging camera. Can be.
하지만, HIFU를 이용한 가열 중의 측정에서는 생체 표면에 음향 특성이 다른 금속성의 온도계를 접촉시키기가 어렵고 생체 표면의 커플링 부위에 온도계를 위치시킬 수도 없어, 접촉형 온도계는 바람직하지 못하다.However, in the measurement during heating using HIFU, it is difficult to contact metallic thermometers with different acoustic characteristics on the surface of the living body, and the thermometer cannot be placed at the coupling site of the living body surface, so that the contact thermometer is not preferable.
또한, 비접촉형 온도계는 고온의 피측정물체로부터 방사되는 예컨대 빛 또는 열과 같은 방사 에너지를 감지하고 온도와 에너지의 일정한 관계를 이용하여 온도를 검출하게 되는데, 방사율의 부적확성 또는 광로 중의 흡수나 산란 등에 의해 오차가 발생하여 생체 표면의 커플링 부위에서의 온도를 정확히 측정하기 곤란하다는 문제점이 있다. 더구나, 온도계 또는 카메라와 더불어, 관련 부품을 설치하는 데에 부품수 및 비용이 증가하는 문제도 있다.In addition, the non-contact thermometer detects radiation energy such as light or heat emitted from an object under high temperature and detects temperature by using a constant relationship between temperature and energy, such as inaccuracy of emissivity or absorption or scattering in an optical path. There is a problem that an error occurs and it is difficult to accurately measure the temperature at the coupling site of the living body surface. In addition to thermometers or cameras, there is also a problem in that the number of parts and the cost of installing the related parts are increased.
본 실시예는 치료시 초음파의 전달을 방해하지 않고서 트랜스듀서의 온도를 신속하고 정확히 파악하게 되어 생체 표면 또는 피부의 손상을 미연에 방지함으로써 치료를 안전하게 수행할 수 있는 트랜스듀서를 제공하는 데에 그 주된 목적이 있다.The present embodiment provides a transducer capable of safely carrying out the treatment by quickly and accurately determining the temperature of the transducer without interrupting the delivery of ultrasound during treatment, thereby preventing damage to the surface or skin of the living body. There is a main purpose.
일 실시예에 따른 트랜스듀서는, 프레임; 상기 프레임에 부착되어 초음파를 조사하는 적어도 하나의 초음파 진동자; 상기 프레임의 일부와 상기 초음파 진동자를 씌우면서 상기 프레임에 장착되어 내부에 초음파 전달매질을 수용하게 되는 멤브레인을 구비하고, 상기 멤브레인이 시온물질을 함유하여 온도 변화에 따라 광학 특성이 변화하는 것을 특징으로 한다. Transducer according to an embodiment, the frame; At least one ultrasonic vibrator attached to the frame to irradiate ultrasonic waves; And a membrane mounted to the frame to cover a part of the frame and the ultrasonic vibrator to receive the ultrasonic transmission medium therein, wherein the membrane contains a Zion material, and the optical properties change according to temperature changes. do.
다른 실시예에 따른 트랜스듀서는, 프레임; 상기 프레임에 부착되어 초음파를 조사하는 적어도 하나의 초음파 진동자; 상기 프레임의 일부와 상기 초음파 진동자를 씌우면서 상기 프레임에 장착되어 내부에 초음파 전달매질을 수용하게 되는 멤브레인을 구비하고, 상기 초음파 전달매질이 시온물질을 함유하여 온도 변화에 따라 광학 특성이 변화하는 것을 특징으로 한다. Transducer according to another embodiment, the frame; At least one ultrasonic vibrator attached to the frame to irradiate ultrasonic waves; And a membrane mounted to the frame to cover a part of the frame and the ultrasonic vibrator to receive the ultrasonic transfer medium therein, wherein the ultrasonic transfer medium contains a Zion material and changes optical characteristics according to temperature change. It features.
이상과 같이 본 실시예에 의하면, 생체와의 접촉 부분 또는 근접한 부위에 온도 변화로 광학 특성이 변화하는 시온물질을 포함하여서, 치료시 초음파의 전달을 방해하지 않고서 트랜스듀서의 온도를 신속하고 정확히 파악하게 되어 생체 표면 또는 피부의 손상을 미연에 방지함으로써 치료를 안전하게 수행할 수 있는 효과가 있게 된다. As described above, according to the present embodiment, a Zion material whose optical properties change due to a temperature change in a contact portion or a close contact with a living body, and quickly and accurately grasp the temperature of the transducer without disturbing the transmission of ultrasound during treatment This prevents damage to the surface of the living body or skin in advance, thereby enabling the treatment to be safely performed.
도 1은 종래기술의 HIFU 치료장치들에 사용되는 트랜스듀서의 한 예를 부분적으로 도시한 단면도이다. 1 is a partial cross-sectional view of an example of a transducer used in prior art HIFU treatment devices.
도 2는 일 실시예에 따른 트랜스듀서를 부분적으로 도시한 단면도이다. 2 is a partial cross-sectional view of a transducer according to an embodiment.
도 3은 다른 실시예에 따른 트랜스듀서를 부분적으로 도시한 단면도이다. 3 is a partial cross-sectional view of a transducer according to another embodiment.
이하, 본 실시예를 첨부된 도면들을 참조하여 상세히 설명한다. 우선 각 도면의 구성요소들에 참조부호를 부가함에 있어서, 동일한 구성요소들에 대해서는 비록 다른 도면상에 표시되더라도 가능한 한 동일한 부호를 가지도록 하고 있음에 유의해야 한다. 또한, 본 실시예를 설명함에 있어, 관련된 공지 구성 또는 기능에 대한 구체적인 설명이 당업자에게 자명하거나 본 실시예의 요지를 흐릴 수 있다고 판단되는 경우에는 그 상세한 설명은 생략한다.Hereinafter, the present embodiment will be described in detail with reference to the accompanying drawings. First of all, in adding reference numerals to the components of each drawing, it should be noted that the same reference numerals are used as much as possible even if displayed on different drawings. In addition, in describing the present embodiment, if a detailed description of the related well-known configuration or function is apparent to those skilled in the art or may make the gist of the present embodiment obscure, the detailed description thereof will be omitted.
도 2는 일 실시예에 따른 트랜스듀서를 부분적으로 도시한 단면도로서, 이에 도시된 바와 같이 제1실시예에 따른 트랜스듀서(200)는, 프레임(101); 이 프레임(101)에 부착되어 초음파를 조사하는 적어도 하나의 초음파 진동자(102); 프레임(101)의 일부와 초음파 진동자(102)를 씌우면서 프레임(101)에 장착되어 내부에 초음파 전달매질(201)을 수용하게 되는 멤브레인(203)을 구비하고, 이 멤브레인(203)은 시온물질을 함유하여 온도 변화에 따라 광학 특성이 변화하게 된다. 2 is a cross-sectional view partially illustrating a transducer according to an embodiment, and as shown therein, the transducer 200 according to the first embodiment includes a frame 101; At least one ultrasonic vibrator 102 attached to the frame 101 to irradiate ultrasonic waves; A membrane 203 is mounted on the frame 101 to cover a part of the frame 101 and the ultrasonic vibrator 102 to receive the ultrasonic transmission medium 201 therein, and the membrane 203 is a Zion material. It contains and the optical properties change with the temperature change.
프레임(101)은 다양한 방열체로 구성될 수 있다. 예를 들면, 알루미늄과 같은 금속으로 된 부재로 형성될 수 있지만, 프레임(101)의 재질은 이에 한정되지 않는다. The frame 101 may be composed of various heat sinks. For example, it may be formed of a member made of metal such as aluminum, but the material of the frame 101 is not limited thereto.
또한, 도면들에서는 대략 반구 형상의 오목한 프레임(101)이 도시되어 있지만, 이에 한정되지 않고 프레임(101)의 평탄한 원판에 다수의 초음파 진동자(102)가 각각 삽입되어 설치될 수 있다. 즉, 프레임(101)의 형상은 후술하는 다수의 초음파 진동자(102)를 구비하면서 치료를 허용할 수만 있다면, 생체 표면과 접촉될 수 있는 다양한 형상으로 형성될 수 있다.In addition, although a substantially hemispherical concave frame 101 is illustrated in the drawings, a plurality of ultrasonic vibrators 102 may be inserted into and installed on the flat disc of the frame 101. That is, the shape of the frame 101 may be formed in various shapes that can be in contact with the surface of the living body, provided that the treatment with the ultrasonic vibrator 102 to be described later to allow treatment.
초음파 진동자(102)는 프레임(101)의 형상에 따라 적절히 형성된 초음파 방사면을 구비하여 단일의 초음파 진동자로 프레임(101)의 표면을 커버하거나, 혹은 수십 내지 수백 개의 초음파 진동자가 원판이나 다각형 평판 형태로 형성되어 프레임(101)에 부착될 수 있다. 후자의 트랜스듀서를 소위 배열형 트랜스듀서라 하는데, 이를 활용하면 부착된 각각의 초음파 진동자에 위상이 다른 전기적 신호를 입력하여 초음파 집속 위치를 가변시킬 수 있다. 즉, 배열형 트랜스듀서는 전기적인 조향만으로 단일 초점을 가변하거나 다중 초점을 생성할 수 있다. 따라서, 넓은 범위의 영역을 치료할 때 트랜스듀서의 기구적 이동이 필요 없으므로 치료 시스템이 단순해지고, 치료 시간을 단축할 수 있는 장점이 있게 된다.The ultrasonic vibrator 102 has an ultrasonic radiating surface suitably formed according to the shape of the frame 101 to cover the surface of the frame 101 with a single ultrasonic vibrator, or dozens or hundreds of ultrasonic vibrators form a disc or a polygonal flat plate. It may be formed to be attached to the frame 101. The latter transducer is called a so-called array transducer, and by utilizing this, the ultrasonic focusing position can be varied by inputting an electrical signal having a different phase to each of the attached ultrasonic transducers. That is, the arrayed transducer can vary a single focal point or generate multiple focal points by electric steering alone. Therefore, since the mechanical movement of the transducer is not required to treat a wide range of areas, the treatment system is simplified and the treatment time can be shortened.
배열형 트랜스듀서에서는 초음파 진동자(102)의 일측에 위치되어 공진 특성을 적절히 형성하도록 된 하나 이상의 음향 정합층을 포함할 수 있다. 또한, 신호라인이 전기적 신호를 초음파 진동자(102)로 전달하도록 연결될 수 있다. 초음파 진동자(102)는 예컨대 PZT(Lead Zirconate Titanate)와 같은 압전 세라믹, 크리스탈, 복합 재료 등과 같은 압전 재료로 만들어질 수 있는 한편, 신호라인은 와이어 형태로 구성될 수 있는데, 다양한 방식으로 배치 및 연결될 수 있어 여기서는 그 상세한 설명을 생략하기로 한다. The arrayed transducer may include one or more acoustic matching layers positioned on one side of the ultrasonic vibrator 102 to appropriately form resonance characteristics. In addition, a signal line may be connected to deliver an electrical signal to the ultrasonic vibrator 102. The ultrasonic vibrator 102 may be made of piezoelectric materials such as piezoelectric ceramics, crystals, composite materials, etc., for example, PZT (Lead Zirconate Titanate), while the signal lines may be configured in the form of wires, which may be arranged and connected in various ways. The detailed description thereof will be omitted here.
초음파 전달매질(201)은 멤브레인(203)과 초음파 진동자(102)의 초음파 방사면 사이에 채워진다. 미설명된 참조부호 105는 멤브레인(203)을 프레임(101)에 연결하기 위한 누름링을 표시한다. 추가로, 초음파 영상장치(미도시)에 연결되고 영상 데이터를 수집하는 이미징용 프로브(120)가 트랜스듀서(200) 내에 설치될 수 있다. The ultrasonic delivery medium 201 is filled between the membrane 203 and the ultrasonic radiating surface of the ultrasonic vibrator 102. Unexplained reference numeral 105 denotes a push ring for connecting the membrane 203 to the frame 101. In addition, an imaging probe 120 connected to an ultrasound imaging apparatus (not shown) and collecting image data may be installed in the transducer 200.
초음파 전달매질(201)은 공기가 제거된 물일 수 있다. 전술한 바와 같이, 바람직한 음향 투과 특성 또는 냉각을 위해 많은 치료 분야에서는 물이 초음파 전달매질로서 통상 사용된다. The ultrasonic delivery medium 201 may be water from which air is removed. As noted above, water is commonly used as the ultrasound delivery medium in many therapeutic applications for desirable acoustic transmission or cooling.
멤브레인(203)은 물과 유사한 음향 임피던스를 갖고, 라텍스, 상대적으로 부드러운 천연 고무, 실리콘 고무, 우레탄 수지 등과 같이 적은 초음파 전달손실, 완벽한 열전도율, 그리고 좋은 탄성을 가진 물질로 제조된다. The membrane 203 has a sound impedance similar to water and is made of a material having low ultrasonic wave transmission loss, perfect thermal conductivity, and good elasticity such as latex, relatively soft natural rubber, silicone rubber, urethane resin, and the like.
멤브레인(203)의 표면은 생체 표면에 접촉 또는 근접하는 부위이다. 이 멤브레인(203)의 표면 온도가 과도하게 상승하게 되면, 생체 표면에 악영향을 주고 심한 경우에는 화상을 입힐 우려가 있다. 그런데 멤브레인(203)의 표면에서의 온도 및 그 분포는, 사용되는 재료의 차이나 초음파 진동자 배열의 차이 등에 의해 달라진다. 또, 실제의 멤브레인(203)의 온도는, 이러한 조건뿐만 아니라 사용 환경에 따라 변하게 되는데, 예를 들면, 외부 기온이나 생체의 체온, 사용 지속 시간, 젤의 존재 유무, 멤브레인(203)의 접촉 위치 등에 의해 변경될 수 있다.The surface of the membrane 203 is a site in contact with or in proximity to the biological surface. If the surface temperature of the membrane 203 rises excessively, it may adversely affect the surface of the living body and, in severe cases, burns. The temperature at the surface of the membrane 203 and its distribution vary depending on the difference in the materials used, the difference in the arrangement of the ultrasonic vibrators, and the like. In addition, the actual temperature of the membrane 203 changes not only in these conditions but also in the use environment. For example, the external temperature, the body temperature of the living body, the duration of use, the presence or absence of a gel, and the contact position of the membrane 203. And the like.
본 실시예에서는 생체 표면에 직접적으로 접촉 또는 근접하게 되는 멤브레인(203)에다 온도에 따라 광학 특성이 변화하는 시온물질이 포함되게 하였다. 특히 제1실시예에서는, 멤브레인(203) 전체를 시온부로 기능시키기 위해, 해당 멤브레인(203)의 재료에 온도 변화에 따라 광학 특성이 변화하는 시온물질을 혼합하고, 혼합된 재료를 이용하여 멤브레인(203)을 형성하였다. In the present embodiment, the membrane 203 which is in direct contact with or in close proximity to the surface of the living body is included with the zion material whose optical properties change with temperature. In particular, in the first embodiment, in order to function the entire membrane 203 as a Zion part, a Zion material whose optical properties change with temperature changes is mixed with the material of the Membrane 203 and the membrane ( 203).
시온물질은, 특별히 한정되지 않지만, 변색의 정밀도가 높고, 색종과 변색 온도의 선택 자유도가 높은 가역성 시온안료를 이용하는 것이 바람직하다. 시온안료로는, 분말상의 시온안료 또는 이 시온안료를 사용하여 제품을 성형할 때 분말상의 안료를 열로부터 보호하고 분산을 좋게 하기 위해 마이크로캡슐로 가공하고, 그 내부에 12 ~ 18 %의 시온안료를 함유한 마스터 배치(Master Batch) 형태의 시온안료를 사용할 수 있다. Although a Zion substance is not specifically limited, It is preferable to use the reversible Zion pigment which has high precision of discoloration, and has high freedom of selection of a color species and a discoloration temperature. Zion pigments are powdered Zion pigments or when the products are formed using the Zion pigments, the pigments are processed into microcapsules to protect the powdered pigments from heat and improve dispersion, and 12 to 18% of Zion pigments therein. Zion pigments in the form of Master Batch may be used.
특히, 시온안료는 온도가 원래대로 되돌아가면 복색(複色)되는 가역성 타입의 것을 사용하는데, 발색의 원리는 고상(固相)반응, 열분해, 탈수, 전자공여체 또는 수용체의 전자 수수(授受), 결정 구조의 변화 등을 이용하고 있다. 일반적으로 가역성 시온안료는 기준 온도가 -15 ℃에서 70 ℃까지인데, 본 실시예에서는 40 ℃ 내지 45 ℃의 온도 범위에서 변색되는 단일의 안료를 사용할 수 있다.In particular, Zion pigments use reversible types that are converted to color when the temperature returns to their original state. The principles of color development are solid phase reaction, pyrolysis, dehydration, electron transfer of electron donor or acceptor, The change in crystal structure is used. Generally, the reversible Zion pigment has a reference temperature of -15 ° C to 70 ° C. In this embodiment, a single pigment that discolors in a temperature range of 40 ° C to 45 ° C may be used.
하지만, 반드시 이에 한정되지 않는데, 예를 들면 30 ~ 60 ℃의 온도에서 색을 변화시킬 경우에, 시온안료의 반응 온도 영역을 10 ℃씩 구분하고, 3 종류 색상의 시온안료를 편성하여 온도를 색상으로 표현할 수 있다. 시온안료의 색상은 15 종류가 있으나, 통상 흑색, 청색, 적색, 황색을 사용하며 나머지 색상은 일반 잉크나 안료를 혼합하여 구현한다. However, the present invention is not necessarily limited thereto. For example, when the color is changed at a temperature of 30 to 60 ° C., the reaction temperature range of the Zion pigment is divided by 10 ° C., and three types of Zion pigments are formed to color the temperature. It can be expressed as There are 15 kinds of colors of Zion pigment, but usually black, blue, red and yellow are used, and the remaining colors are realized by mixing general ink or pigment.
30 ~ 60 ℃의 사이로, 흑색으로부터 적색으로 변색시키는 경우의 재료 편성을 예로 들어 설명하자면, 35 ℃ 부근에서 황색으로부터 투명으로 변색하는 제1시온안료, 45 ℃ 부근에서 적색으로부터 투명으로 변색하는 제2시온안료, 55 ℃ 부근에서 청색으로부터 투명으로 변색하는 제3시온안료, 및 기본 색상으로 적색을 표출하는 바탕색 안료를 조합하면 좋다. 이들 바탕색 안료 및 3 종류의 시온안료를 조합시키는 것으로, 30 ~ 60 ℃의 사이에서 온도 변화에 따라 흑색으로부터 적색으로 변색하는 재료가 얻어지게 된다.For example, the first Zion pigment which changes color from yellow to transparent at around 35 ° C, and the second color changing from red to transparent at about 45 ° C It is good to combine Zion pigment, the 3rd Zion pigment which discolors from blue to transparent near 55 degreeC, and the ground color pigment which expresses red by a basic color. By combining these ground color pigments and three kinds of Zion pigments, a material which changes color from black to red with a temperature change between 30 to 60 ° C is obtained.
이와 같이, 시온안료와 일반 바탕색 안료를 조합하여, 온도가 안 올라가면 혼합된 색상을 나타내고 있다가 온도가 올라가면 시온안료의 색상은 투명하게 변화되고 바탕색 안료의 색상만 나타나게 하는 이중 또는 다중 색상의 효과를 낼 수 있는 것이 좋다. 단, 색상 결정시 바탕색 안료의 색상에 유의해야 하는데, 바탕색 안료의 색상이 진하고 시온안료가 밝으면 은폐력이 떨어져 바탕색이 드러나게 될 수도 있다. In this way, a combination of Zion Pigment and General Background Pigment is used to show the mixed color when the temperature does not rise, and when the temperature is raised, the color of Zion Pigment is changed to transparent and only the color of the background pigment is displayed. It is good to be able to pay. However, when determining the color, it is necessary to pay attention to the color of the background color pigment. If the color of the background color pigment is dark and the Zion pigment is bright, the background color may be revealed due to the hiding power.
물론, 비가역성 타입의 시온안료를 사용할 수 있지만, 이러한 비가역성 타입의 것은 원래의 색상으로 되돌아가지 않는 1회성이며, 40 ~ 450 ℃의 온도 범위를 갖는다. Of course, an irreversible type of Zion pigment can be used, but this irreversible type is a one-time reversal which does not return to the original color, and has a temperature range of 40 to 450 ° C.
이상과 같은 시온물질을 멤브레인(203)에 혼합하여 제조하게 되면, 멤브레인(203) 자체의 온도에 따라 멤브레인(203)의 색상이 변화하게 되고, 이에 따라 종래에 비해 더욱 정확히 멤브레인(203) 및 생체 표면의 온도를 멤브레인(203)의 색상을 매개로 하여 육안으로 신속하고 정확히 그리고 용이하게 파악할 수 있다. 동시에, 멤브레인(203) 전체가 온도를 나타내고 있기 때문에, 온도 분포 등도 확실하게 파악할 수 있다. 이러한 온도 변화의 확인을 통해 치료를 제어할 수 있어 궁극적으로 생체 표면 또는 피부의 화상을 미연에 방지하고 치료를 안전하게 수행할 수 있다. 또, 온도에 따라 색상을 변화시키는 시온물질이 멤브레인(203)의 재료에 혼합되어 있기 때문에, 종래의 온도계 또는 온도센서 등을 사용한 기술과 차이가 있으며 초음파의 전달에 방해되지도 않는다. When the Zion material is prepared by mixing the membrane 203 as described above, the color of the membrane 203 is changed according to the temperature of the membrane 203 itself, and thus the membrane 203 and the living body are more accurately compared to the conventional one. The temperature of the surface can be grasped quickly, accurately and easily with the naked eye through the color of the membrane 203. At the same time, since the whole membrane 203 shows temperature, temperature distribution etc. can also be grasped reliably. The identification of these changes in temperature allows the treatment to be controlled, ultimately preventing burns on the surface of the living body or skin and safely performing the treatment. In addition, since the zion material that changes color depending on the temperature is mixed with the material of the membrane 203, there is a difference from the technique using a conventional thermometer or a temperature sensor, and does not interfere with the transmission of ultrasonic waves.
추가로 본 실시예에서는, 멤브레인(203)의 재료에 시온물질을 혼합한 예를 기술하고 있지만, 멤브레인(203)의 적어도 일부에 시온물질을 접착 또는 도포하여도 된다. 예를 들면, 시온물질이 혼입된 재료로 형성시킨 얇은 막을 제작하고, 이 막을 멤브레인(203)의 표면에 접착한다. 혹은, 시온물질을 함유한 액체를 멤브레인(203)의 표면에 도포할 수도 있다. 이처럼, 시온물질을 멤브레인(203)의 표면에 접착 또는 도포함으로써, 시온물질이 포함되어 있지 않은 기존의 트랜스듀서(예컨대 100)에도 시온부를 용이하게 형성할 수 있다.In addition, in this embodiment, although the example which mixed the Zion material with the material of the membrane 203 is described, you may adhere | attach or apply a Zion material to at least one part of the membrane 203. As shown in FIG. For example, a thin film formed of a material in which a Zion material is mixed is produced, and the film is adhered to the surface of the membrane 203. Alternatively, a liquid containing Zion material may be applied to the surface of the membrane 203. As such, by attaching or applying the Zion material to the surface of the membrane 203, the Zion part may be easily formed in the existing transducer (eg, 100) that does not contain the Zion material.
도 3은 다른 실시예에 따른 트랜스듀서를 부분적으로 도시한 단면도로서, 이에 도시된 바와 같이 제2실시예에 따른 HIFU용 트랜스듀서(300)는, 프레임(101); 이 프레임(101)에 부착되어 초음파를 조사하는 적어도 하나의 초음파 진동자(102); 프레임(101)의 일부와 초음파 진동자(102)를 씌우면서 프레임(101)에 장착되어 내부에 초음파 전달매질(301)을 수용하게 되는 멤브레인(303)을 구비하고, 초음파 전달매질(301)이 시온물질을 함유하여 온도 변화에 따라 광학 특성이 변화하게 된다. 3 is a cross-sectional view partially showing a transducer according to another embodiment, and as shown therein, the HIFU transducer 300 according to the second embodiment includes a frame 101; At least one ultrasonic vibrator 102 attached to the frame 101 to irradiate ultrasonic waves; A membrane 303 is mounted on the frame 101 to cover a part of the frame 101 and the ultrasonic vibrator 102 to receive the ultrasonic transfer medium 301 therein, and the ultrasonic transfer medium 301 is Zion. It contains a substance that changes its optical properties with temperature changes.
제2실시예에 따른 트랜스듀서(300)는, 제1실시예에 따른 트랜스듀서(200)의 멤브레인(203) 대신에 초음파 전달매질(301)에 시온물질을 포함한 것을 제외하고 그 구성 및 작용이 제1실시예에 따른 트랜스듀서(200)와 동일하기 때문에, 본 제2실시예에 따른 트랜스듀서(300)를 설명함에 있어, 제1실시예에 따른 트랜스듀서(200)와 동일한 구성요소에 대해서는 동일한 부호를 부여하면서 그 구성 및 기능의 상세한 설명을 생략하기로 한다.The transducer 300 according to the second embodiment has a configuration and operation except that Zion material is included in the ultrasonic transfer medium 301 instead of the membrane 203 of the transducer 200 according to the first embodiment. Since it is the same as the transducer 200 according to the first embodiment, in describing the transducer 300 according to the second embodiment, the same components as those of the transducer 200 according to the first embodiment will be described. The same reference numerals will be used to omit the detailed description of the structure and function.
전술한 바와 같이 초음파 전달매질(301)은 공기가 제거된 물일 수 있다. 본 실시예에서는 이러한 초음파 전달매질(301), 즉 생체 표면에 근접하게 되는 물에다 온도에 따라 광학 특성이 변화하는 시온물질이 포함되게 하였다. As described above, the ultrasonic transfer medium 301 may be water from which air is removed. In the present embodiment, the ultrasonic delivery medium 301, that is, water that is close to the surface of the living body, includes a zion material whose optical properties change with temperature.
시온물질로는, 특별히 한정되지 않지만, 변색의 정밀도가 높고, 색종과 변색 온도의 선택 자유도가 높은 가역성 시온안료를 이용하는 것이 바람직하다. 시온안료로는 수성 슬러리 형태의 시온안료를 사용하며, 온도가 원래대로 되돌아가면 복색되는 가역성 타입의 것을 사용한다. 이러한 수성 슬러리는 수성 잉크나 수성 용액에 잘 섞이도록 액체의 형태로 되어 물에 원활히 분산되게 되어 있다. Although it does not specifically limit as a Zion material, It is preferable to use the reversible Zion pigment which has high precision of discoloration, and has high freedom of selection of a color species and discoloration temperature. Zion pigments are used as Zion pigments in the form of aqueous slurries, and reversible types are used that revert when the temperature returns to the original state. These aqueous slurries are in the form of a liquid so as to mix well with an aqueous ink or an aqueous solution, and are dispersed in water smoothly.
가역성 시온안료는 기준 온도가 대체로 -15 ℃에서 70 ℃까지인데, 본 실시예에서는 40 ℃ 내지 45 ℃의 온도 범위에서 변색되는 단일의 안료를 사용할 수 있다. 하지만, 반드시 이에 한정되지 않는데, 2 종류 색상 이상의 시온안료를 편성하여 온도를 색상으로 표현할 수 있다. 또한, 시온안료와 일반 잉크를 조합하여, 온도가 안 올라가면 혼합된 색상을 나타내고 있다가 온도가 올라가면 시온안료의 색상은 투명하게 변화되고 일반 잉크의 색상만 나타나게 하는 이중 또는 다중 색상의 효과를 낼 수도 있다. Reversible Zion pigments have a reference temperature of generally -15 ° C to 70 ° C. In this embodiment, a single pigment that discolors in a temperature range of 40 ° C to 45 ° C may be used. However, the present invention is not necessarily limited thereto, and two or more types of Zion pigments may be combined to express temperature in color. In addition, a combination of Zion Pigment and General Ink shows a mixed color when the temperature is not raised, and when the temperature is raised, the Zion Pigment is changed to a transparent color. have.
멤브레인(303)은 물과 유사한 음향 임피던스를 갖고, 적은 초음파 전달손실, 완벽한 열전도율, 그리고 좋은 탄성을 가진 물질로 제조된다. 이때, 멤브레인(303)은 시각적으로 투명 또는 반투명인 것이 바람직하다. 그러나 반드시 이에 한정되는 것은 아니다. The membrane 303 has a sound impedance similar to that of water, and is made of a material having low ultrasonic transmission loss, perfect thermal conductivity, and good elasticity. At this time, the membrane 303 is preferably visually transparent or translucent. However, it is not necessarily limited thereto.
이상과 같이 시온물질을 초음파 전달매질(301)에 혼입시킨 경우에, 초음파 전달매질(301) 자체의 온도에 따라 초음파 전달매질(301)의 색상이 변화하게 되고, 이러한 색상 변화로 인해 멤브레인(303)의 색상도 변화한 것처럼 보이게 된다. 이에 따라, 종래에 비해 더욱 정확히 초음파 전달매질(301) 또는 멤브레인(303) 및 생체 표면의 온도를 초음파 전달매질(301)의 색상을 매개로 하여 육안으로 신속하고 정확히 그리고 용이하게 파악할 수 있다. 이와 같은 온도 변화의 확인을 통해 치료를 제어할 수 있어 궁극적으로 생체 표면 또는 피부의 화상을 미연에 방지하고 치료를 안전하게 수행할 수 있다. 또, 온도에 따라 색상을 변화시키는 시온물질이 초음파 전달매질(301)에 함유되어 있기 때문에, 종래의 온도계 또는 온도센서 등을 사용한 기술과 차이가 있고 초음파의 전달에 방해되지도 않는다. When the Zion material is incorporated into the ultrasonic delivery medium 301 as described above, the color of the ultrasonic delivery medium 301 is changed according to the temperature of the ultrasonic delivery medium 301 itself, and due to the color change, the membrane 303 ) Will also appear to change color. Accordingly, the temperature of the ultrasonic delivery medium 301 or the membrane 303 and the surface of the living body can be quickly and accurately identified with the naked eye through the color of the ultrasonic delivery medium 301 as compared with the conventional art. The identification of such temperature changes allows the treatment to be controlled, ultimately preventing burns on the surface of the living body or skin and safely performing the treatment. In addition, since the Zion material that changes color depending on the temperature is contained in the ultrasonic transmission medium 301, there is a difference from the conventional technique using a thermometer or a temperature sensor, and does not interfere with the transmission of ultrasonic waves.
추가로, 본 제2실시예에 따른 트랜스듀서(300)는 초음파 전달매질(301)에 시온물질을 혼합하기만 하면 되기 때문에, 제1실시예에 따른 트랜스듀서(200)의 멤브레인(203)과는 달리 혼합 후 경화 또는 성형 등의 공정이 필요 없어, 제1실시예에 따른 트랜스듀서(200)보다 구성 및 제조하기가 훨씬 수월한 장점이 있다. In addition, since the transducer 300 according to the second embodiment only needs to mix a Zion material in the ultrasonic delivery medium 301, the membrane 203 and the membrane 203 of the transducer 200 according to the first embodiment may be used. Since there is no need for a process such as curing or molding after mixing, there is an advantage that it is much easier to configure and manufacture than the transducer 200 according to the first embodiment.
이상의 설명은 본 실시예의 기술 사상을 예시적으로 설명한 것에 불과한 것으로서, 본 실시예가 속하는 기술 분야에서 통상의 지식을 가진 자라면 본 실시예의 본질적인 특성에서 벗어나지 않는 범위에서 다양한 수정 및 변형이 가능할 것이다. 따라서, 개시된 본 실시예는 그 기술 사상을 한정하기 위한 것이 아니라 설명하기 위한 것이고, 이러한 실시예에 의하여 그 기술 사상의 범위가 한정되는 것은 아니다. 본 실시예의 보호 범위는 아래의 청구범위에 의하여 해석되어야 하며, 그와 동등한 범위 내에 있는 모든 기술 사상은 본 실시예의 권리범위에 포함되는 것으로 해석되어야 할 것이다.The above description is merely illustrative of the technical idea of the present embodiment, and those skilled in the art to which the present embodiment belongs may make various modifications and changes without departing from the essential characteristics of the present embodiment. Accordingly, the disclosed embodiments are not intended to limit the technical spirit of the present invention but to describe the technical spirit, and the scope of the technical spirit is not limited by these embodiments. The scope of protection of the present embodiment should be interpreted by the following claims, and all technical ideas within the scope equivalent thereto should be construed as being included in the scope of the present embodiment.
(부호의 설명)(Explanation of the sign)
100, 200, 300 : 트랜스듀서100, 200, 300: transducer
101 : 프레임101: frame
102 : 초음파 진동자102: ultrasonic vibrator
201, 301 : 초음파 전달매질201, 301: ultrasonic delivery medium
203, 303 : 멤브레인203, 303: membrane

Claims (12)

  1. 프레임; frame;
    상기 프레임에 부착되어 초음파를 조사하는 적어도 하나의 초음파 진동자;At least one ultrasonic vibrator attached to the frame to irradiate ultrasonic waves;
    상기 프레임의 일부와 상기 초음파 진동자를 씌우면서 상기 프레임에 장착되어 내부에 초음파 전달매질을 수용하게 되는 멤브레인Membrane mounted on the frame while covering the part of the frame and the ultrasonic vibrator to receive the ultrasonic transmission medium therein
    을 구비하고, And
    상기 멤브레인이 시온물질을 함유하여 온도 변화에 따라 광학 특성이 변화하는 것을 특징으로 하는 트랜스듀서. Transducer, characterized in that the membrane contains a Zion material, the optical properties change with temperature changes.
  2. 제1항에 있어서, The method of claim 1,
    상기 멤브레인은 성형 재료에 상기 시온물질을 혼합하여 형성된 트랜스듀서. The membrane is formed by mixing the Zion material with a molding material.
  3. 제1항에 있어서, The method of claim 1,
    상기 멤브레인의 적어도 일부에 상기 시온물질을 접착 또는 도포한 트랜스듀서. Transducer to which the Zion material is adhered or applied to at least a portion of the membrane.
  4. 제2항 또는 제3항에 있어서, The method according to claim 2 or 3,
    상기 시온물질은 가역성 시온안료인 트랜스듀서. The Zion material is a reversible Zion pigment.
  5. 제4항에 있어서, The method of claim 4, wherein
    상기 시온물질은 온도 차이가 있는 둘 이상의 시온안료를 조합한 것인 트랜스듀서. The Zion material is a transducer that is a combination of two or more Zion pigment with a temperature difference.
  6. 제4항에 있어서,The method of claim 4, wherein
    상기 시온물질은 시온안료와 일반 안료를 조합한 것인 트랜스듀서. The Zion material is a transducer that combines a Zion pigment and a general pigment.
  7. 프레임; frame;
    상기 프레임에 부착되어 초음파를 조사하는 적어도 하나의 초음파 진동자;At least one ultrasonic vibrator attached to the frame to irradiate ultrasonic waves;
    상기 프레임의 일부와 상기 초음파 진동자를 씌우면서 상기 프레임에 장착되어 내부에 초음파 전달매질을 수용하게 되는 멤브레인Membrane mounted on the frame while covering the part of the frame and the ultrasonic vibrator to receive the ultrasonic transmission medium therein
    을 구비하고, And
    상기 초음파 전달매질이 시온물질을 함유하여 온도 변화에 따라 광학 특성이 변화하는 것을 특징으로 하는 트랜스듀서. The ultrasonic transmission medium contains a Zion material, the transducer, characterized in that the optical properties change with temperature changes.
  8. 제7항에 있어서, The method of claim 7, wherein
    상기 시온물질은 가역성 시온안료인 트랜스듀서. The Zion material is a reversible Zion pigment.
  9. 제8항에 있어서, The method of claim 8,
    상기 시온안료는 수성 슬러리 형태인 트랜스듀서. The Zion pigment is a transducer in the form of an aqueous slurry.
  10. 제8항에 있어서, The method of claim 8,
    상기 시온물질은 온도 차이가 있는 둘 이상의 시온안료를 조합한 것인 트랜스듀서. The Zion material is a transducer that is a combination of two or more Zion pigment with a temperature difference.
  11. 제8항에 있어서,The method of claim 8,
    상기 시온물질은 시온안료와 일반 잉크를 조합한 것인 트랜스듀서. The Zion material is a combination of a Zion pigment and a general ink.
  12. 제7항에 있어서, The method of claim 7, wherein
    상기 멤브레인은 시각적으로 투명 또는 반투명인 트랜스듀서.The membrane is visually transparent or translucent.
PCT/KR2013/004131 2013-05-10 2013-05-10 Transducer WO2014181903A1 (en)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07275378A (en) * 1994-04-08 1995-10-24 Shimadzu Corp Therapeutic apparatus
KR100698582B1 (en) * 2006-02-15 2007-03-21 주식회사 에이치엔티메디칼 Apparatus for generating shock wave and shock wave treatment apparatus
KR100830638B1 (en) * 2001-11-05 2008-05-20 베이징 유안데 바이오메디칼 프로젝트 컴파니 리미티드 The structure containing the conductive medium for the source of the external high-power focusing ultrasonic treatment
KR100969543B1 (en) * 2006-01-06 2010-07-12 주식회사 메디슨 3-dimension probe
JP2011172807A (en) * 2010-02-25 2011-09-08 Hitachi Aloka Medical Ltd Ultrasonic probe and ultrasonic diagnostic equipment

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07275378A (en) * 1994-04-08 1995-10-24 Shimadzu Corp Therapeutic apparatus
KR100830638B1 (en) * 2001-11-05 2008-05-20 베이징 유안데 바이오메디칼 프로젝트 컴파니 리미티드 The structure containing the conductive medium for the source of the external high-power focusing ultrasonic treatment
KR100969543B1 (en) * 2006-01-06 2010-07-12 주식회사 메디슨 3-dimension probe
KR100698582B1 (en) * 2006-02-15 2007-03-21 주식회사 에이치엔티메디칼 Apparatus for generating shock wave and shock wave treatment apparatus
JP2011172807A (en) * 2010-02-25 2011-09-08 Hitachi Aloka Medical Ltd Ultrasonic probe and ultrasonic diagnostic equipment

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