WO2014172488A3 - Chemically and thermodynamically stable insulin analogues and improved methods for their production - Google Patents

Chemically and thermodynamically stable insulin analogues and improved methods for their production Download PDF

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Publication number
WO2014172488A3
WO2014172488A3 PCT/US2014/034411 US2014034411W WO2014172488A3 WO 2014172488 A3 WO2014172488 A3 WO 2014172488A3 US 2014034411 W US2014034411 W US 2014034411W WO 2014172488 A3 WO2014172488 A3 WO 2014172488A3
Authority
WO
WIPO (PCT)
Prior art keywords
chemically
improved methods
thermodynamically stable
production
insulin analogues
Prior art date
Application number
PCT/US2014/034411
Other languages
French (fr)
Other versions
WO2014172488A2 (en
Inventor
Michael H.B. Stowell
Yanyu PENG
Mikhail Plam
Original Assignee
AmideBio LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AmideBio LLC filed Critical AmideBio LLC
Priority to EP14785749.4A priority Critical patent/EP2986315A4/en
Publication of WO2014172488A2 publication Critical patent/WO2014172488A2/en
Publication of WO2014172488A3 publication Critical patent/WO2014172488A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The subject matter of this invention is directed towards chemically and thermodynamically stable single-chain insulin (SCI) analogues that are resistant to deamidation and fibrillation. The invention further discloses improved methods for the recombinant expression, purification and refolding of SCI.
PCT/US2014/034411 2013-04-17 2014-04-16 Chemically and thermodynamically stable insulin analogues and improved methods for their production WO2014172488A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP14785749.4A EP2986315A4 (en) 2013-04-17 2014-04-16 Chemically and thermodynamically stable insulin analogues and improved methods for their production

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361813174P 2013-04-17 2013-04-17
US61/813,174 2013-04-17

Publications (2)

Publication Number Publication Date
WO2014172488A2 WO2014172488A2 (en) 2014-10-23
WO2014172488A3 true WO2014172488A3 (en) 2015-03-05

Family

ID=51729461

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2014/034411 WO2014172488A2 (en) 2013-04-17 2014-04-16 Chemically and thermodynamically stable insulin analogues and improved methods for their production

Country Status (3)

Country Link
US (3) US9163073B2 (en)
EP (1) EP2986315A4 (en)
WO (1) WO2014172488A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130137645A1 (en) * 2010-07-19 2013-05-30 Mary S. Rosendahl Modified peptides and proteins
EP2768520A4 (en) 2011-10-18 2015-07-15 AmideBio LLC Chemically and thermodynamically stable insulin analogues and improved methods for their production
US10745457B2 (en) 2015-09-02 2020-08-18 Merck Sharp & Dohme Corp. Process for obtaining insulin with correctly formed disulfide bonds
WO2018187147A1 (en) * 2017-04-03 2018-10-11 Amidebio, Llc Glucose-responsive insulin analogs and methods of use thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040014169A1 (en) * 2000-03-08 2004-01-22 Gabriel Vogeli Novel G protein-coupled receptors
US20070129284A1 (en) * 2003-12-03 2007-06-07 Novo Nordisk A/S Single-chain insulin
US20110112990A1 (en) * 2009-11-09 2011-05-12 The Regents Of The University Of Colorado, A Body Corporate Efficient Production of Peptides
US8192957B2 (en) * 2006-10-04 2012-06-05 Case Western Reserve University Fibrillation-resistant insulin and insulin analogues

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995016708A1 (en) 1993-12-17 1995-06-22 Novo Nordisk A/S Proinsulin-like compounds
KR0150565B1 (en) 1995-02-15 1998-08-17 김정재 A process for preparing human proinsulin by recombinant dna technology
JP2002543092A (en) 1999-04-27 2002-12-17 イーライ・リリー・アンド・カンパニー Insulin crystals for pulmonary administration
WO2000073793A2 (en) 1999-05-27 2000-12-07 Cecil Yip Identification of compounds modulating insulin receptor activity
DE60104069T2 (en) 2000-10-02 2005-08-25 Yonsei University Single-chain insulin analogs
US7638138B2 (en) 2003-02-21 2009-12-29 Translational Research, Ltd. Compositions for nasal administration of pharmaceuticals
EA014887B1 (en) 2003-06-17 2011-02-28 Сембайосиз Джинетикс Инк. Method for the expression of insulin in plant seeds, a method for obtaining plant seeds comprising insulin and a plant capable of setting seeds comprising insulin
JP5256199B2 (en) 2006-08-07 2013-08-07 テヴァ バイオファーマシューティカルズ ユーエスエー，インコーポレーティッド Albumin-insulin fusion protein
CN101541830A (en) 2006-09-22 2009-09-23 诺沃-诺迪斯克有限公司 Protease resistant insulin analogues
US7790677B2 (en) 2006-12-13 2010-09-07 Elona Biotechnologies Insulin production methods and pro-insulin constructs
EP2116264B1 (en) 2006-12-26 2017-09-27 Shin Nippon Biomedical Laboratories, Ltd. Preparation for transnasal application
EP2152294B1 (en) 2007-05-02 2017-07-26 Dana-Farber Cancer Institute, Inc. A bad bh3 domain peptide for use in treating or delaying the onset of diabetes.
CA2711749A1 (en) 2008-01-09 2009-07-16 Sanofi-Aventis Deutschland Gmbh Novel insulin derivatives having an extremely delayed time-action profile
US8993516B2 (en) 2008-04-14 2015-03-31 Case Western Reserve University Meal-time insulin analogues of enhanced stability
KR20120129875A (en) 2008-07-31 2012-11-28 케이스 웨스턴 리저브 유니버시티 Insulin analogues with chlorinated amino acids
ES2705249T3 (en) 2009-06-08 2019-03-22 Amunix Operating Inc Glucose regulating polypeptides and methods for their production and use
EP2768520A4 (en) 2011-10-18 2015-07-15 AmideBio LLC Chemically and thermodynamically stable insulin analogues and improved methods for their production

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040014169A1 (en) * 2000-03-08 2004-01-22 Gabriel Vogeli Novel G protein-coupled receptors
US20070129284A1 (en) * 2003-12-03 2007-06-07 Novo Nordisk A/S Single-chain insulin
US8192957B2 (en) * 2006-10-04 2012-06-05 Case Western Reserve University Fibrillation-resistant insulin and insulin analogues
US20110112990A1 (en) * 2009-11-09 2011-05-12 The Regents Of The University Of Colorado, A Body Corporate Efficient Production of Peptides

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BHATLA, S ET AL.: "Use Of Oil Bodies And Oleosins In Recombinant Protein Production And Other Biotechnological Applications.", BIOTECHNOLOGY ADVANCES., vol. 28, pages 293 - 300, XP026983663 *
See also references of EP2986315A4 *

Also Published As

Publication number Publication date
EP2986315A4 (en) 2017-03-01
EP2986315A2 (en) 2016-02-24
US9163073B2 (en) 2015-10-20
WO2014172488A2 (en) 2014-10-23
US20170368147A1 (en) 2017-12-28
US20160166653A1 (en) 2016-06-16
US20140315798A1 (en) 2014-10-23

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