WO2014112238A1 - 超音波プローブシステム - Google Patents
超音波プローブシステム Download PDFInfo
- Publication number
- WO2014112238A1 WO2014112238A1 PCT/JP2013/082725 JP2013082725W WO2014112238A1 WO 2014112238 A1 WO2014112238 A1 WO 2014112238A1 JP 2013082725 W JP2013082725 W JP 2013082725W WO 2014112238 A1 WO2014112238 A1 WO 2014112238A1
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- WIPO (PCT)
- Prior art keywords
- axial direction
- main body
- distal end
- sheath
- ultrasonic probe
- Prior art date
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
- G01N29/22—Details, e.g. general constructional or apparatus details
- G01N29/24—Probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/12—Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/012—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor characterised by internal passages or accessories therefor
- A61B1/018—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor characterised by internal passages or accessories therefor for receiving instruments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
- A61B10/0233—Pointed or sharp biopsy instruments
- A61B10/0266—Pointed or sharp biopsy instruments means for severing sample
- A61B10/0275—Pointed or sharp biopsy instruments means for severing sample with sample notch, e.g. on the side of inner stylet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4444—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to the probe
- A61B8/445—Details of catheter construction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
- G01N29/04—Analysing solids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/36—Image-producing devices or illumination devices not otherwise provided for
- A61B90/37—Surgical systems with images on a monitor during operation
- A61B2090/378—Surgical systems with images on a monitor during operation using ultrasound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4444—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to the probe
- A61B8/4461—Features of the scanning mechanism, e.g. for moving the transducer within the housing of the probe
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2291/00—Indexing codes associated with group G01N29/00
- G01N2291/02—Indexing codes associated with the analysed material
- G01N2291/023—Solids
Definitions
- the present invention relates to an ultrasonic probe system including a sheath part that accommodates an elongated main body part provided with an ultrasonic observation part so as to be movable back and forth in the insertion axis direction.
- Japanese Patent Application Laid-Open No. 2004-216159 discloses an ultrasonic observation in which a sheath is inserted into a lumen together with an ultrasonic probe in a state where the ultrasonic probe is inserted into the sheath, and is provided at the axial tip of the ultrasonic probe.
- the ultrasonic probe is used to remove the ultrasonic probe from the sheath.
- a method for collecting a specimen which is a living tissue at a site to be examined, by inserting the specimen collection tool described above into a sheath and a configuration of an ultrasonic probe system are disclosed.
- the present invention has been made in view of the above circumstances, and provides an ultrasonic probe system having a configuration capable of collecting a specimen at a site to be examined during ultrasonic observation and easily taking out the collected specimen. For the purpose.
- an ultrasonic probe system is provided with a rod-shaped main body and an ultrasonic wave that is provided in the main body, transmits ultrasonic waves in a side surface direction of the main body, and receives reflected waves.
- a sound wave observation part and a base end surface which is a base end side surface, are provided so as to be adjacent to the front end in the axial direction of the main body part, a front end part having a larger diameter than the main body part, and a larger diameter than the main body part
- a cylindrical sheath part that accommodates the main body part in the axial direction so as to be movable back and forth, a distal end face that is disposed at a distal end of the sheath part and faces the proximal end face, the proximal end face, and the distal end
- a sample collection unit provided on at least one of the surfaces and having an entire circumference in the axial direction to separate the sample in an annular shape from the subject, and the annular sample collected by the sample collection unit is cut Therefore, with respect to the entire circumference of the sample collection unit To anda cutting portion disposed on the proximal face or the distal end face to the difference.
- FIG. 2 is a partial cross-sectional view showing the distal end side in the axial direction of the ultrasonic probe system when the sample collection port of FIG. 1 is open.
- the perspective view which expands and shows the front end side of the axial direction of the sheath part of FIG. 1 with a blade part.
- FIG. 2 is a partial cross-sectional view showing the position in the axial direction when the sample collection port of FIG. 1 is closed in each operation member of the sheath part and the main body part provided in the middle position in the axial direction of the ultrasonic probe system of FIG.
- FIG. 5 is a partial cross-sectional view showing the position in the axial direction when the sample collection port of FIG. 2 is open in each operation member of the sheath part and the main body part of FIG. 4.
- FIG. 6 is a partial cross-sectional view showing a state in which the axial positions of the respective operation members of the sheath portion and the main body portion shown in FIG. 5 are fixed when the sample collection port of FIG.
- FIG. 7 is a plan view of an O-ring stopper member viewed from the VII direction in FIG. 6.
- the figure which shows a mode that an ultrasonic probe system is inserted in the one lumen
- the fragmentary sectional view of the axial direction front end side of the ultrasonic probe system which shows the structure by which a front-end
- the fragmentary sectional view which shows the front end side of the axial direction of the ultrasonic probe system of 2nd Embodiment in the state in which the sample-collecting port is closed.
- FIG. 11 is a partial cross-sectional view showing an axial front end side of the ultrasonic probe system when the sample collection port of FIG. 10 is open.
- FIG. 11 is a partial cross-sectional view on the distal end side in the axial direction of an ultrasonic probe system showing a modification in which a step portion is provided at a portion of an inner peripheral surface facing the housing portion of the sheath portion of FIG.
- FIG. 13 is a partial cross-sectional view showing the distal end side in the axial direction of the ultrasonic probe system when the sample collection port of FIG. 12 is open.
- FIG. 11 is a partial cross-sectional view schematically showing a connector provided at a proximal end of the ultrasonic probe system of FIG. 10.
- FIG. 11 is a partial cross-sectional view on the distal end side in the axial direction of the ultrasonic probe system showing a configuration of a modified example in which a blade portion is removed from a housing portion of the ultrasonic probe system of FIG. A portion on the distal end side in the axial direction of the ultrasonic probe system showing a configuration of a modified example in which a plurality of grooves along the axial direction are formed along the circumferential direction on the inner peripheral surface of the sheath portion of the ultrasonic probe system in FIG. Sectional drawing. Sectional drawing of the sheath part which follows the XVII-XVII line in FIG.
- FIG. 10 is a partial sectional view of the tip end side in the axial direction of the ultrasonic probe system showing a configuration of a modification in which a plurality of grooves along the axial direction are formed along the circumferential direction on the outer peripheral surface of the main body portion of the ultrasonic probe system in FIG. Figure.
- wire in FIG. The figure which shows schematically the endoscope system which comprises the ultrasonic probe system of 1st and 2nd embodiment.
- FIG. 1 is a partial cross-sectional view showing the distal end side in the axial direction of the ultrasonic probe system of the present embodiment with the sample collection port closed, and FIG. 2 shows ultrasonic waves with the sample collection port of FIG. 1 open. It is a fragmentary sectional view which shows the front end side of the axial direction of a probe system.
- FIG. 3 is an enlarged perspective view showing the distal end side in the axial direction of the sheath portion in FIG. 1 together with the blade portion, and FIG. 4 is provided at a midway position in the axial direction of the ultrasonic probe system in FIG.
- FIG. 5 is a partial cross-sectional view showing the position in the axial direction when the sample collection port of FIG. 1 is closed in each operation member of the sheath portion and the main body portion, and FIG. 5 is a view of each operation member of the sheath portion and the main body portion in FIG.
- FIG. 3 is a partial cross-sectional view showing the position in the axial direction when the sample collection port of FIG. 2 is in an open state.
- FIG. 6 is a partial cross-sectional view showing a state in which the axial positions of the respective operation members of the sheath portion and the main body portion shown in FIG. 5 are fixed in a state where the sample collection port of FIG. 2 is closed
- FIG. 6 is a plan view of an O-ring stopper member viewed from the VII direction in FIG.
- the ultrasonic probe system 1 is inserted into a treatment instrument insertion channel (not shown) formed in, for example, an insertion portion 122a (see FIG. 20) of an endoscope 122, It is inserted into the subject alone, and has a rod-like, ie, elongated tubular main body portion 2 that is inserted into the subject through the treatment instrument insertion channel or directly.
- the main body 2 may be hard, may be deformable, and may be formed of a material having elasticity, for example.
- a specific example of the material having elasticity is a polyamide-based resin.
- the main-body part 2 is formed from the material whose stretchability in the axial direction E of the main-body part 2 is higher than the sheath part 5 mentioned later.
- An ultrasonic observation unit 13 that obtains an ultrasonic image in the subject by transmitting ultrasonic waves in the side surface direction S intersecting the axial direction E of the main body 2 to the distal end side in the axial direction E in the inside 2 i of the main body 2. Is provided.
- the ultrasonic observation unit 13 is composed of a ring-shaped ultrasonic transducer, and is fixed to the distal end side in the axial direction E in the inside 2i of the main body 2 by an adhesive 11 and fixed to a substrate 14 on which an IC 12 is mounted. Has been.
- the ultrasonic transducer cable 15 extends from the substrate 14 to the rear in the axial direction E in the inside 2i of the main body 2.
- the extending end of the ultrasonic transducer cable 15 is electrically connected to an electrical connector 51 (both see FIG. 14) in a connector 40 (described later) fixed to the proximal end in the axial direction E of the main body 2.
- the ultrasonic transducer cable 15 transmits an electric pulse signal from the ultrasonic observation device 123 (see FIG. 20) to which the electric connector 51 is connected to the ultrasonic observation unit 13.
- a tip 3 having a diameter larger than that of the main body 2 is provided at the front end in the axial direction E of the main body 2.
- the distal end portion 3 has an inclined surface in which the proximal end surface 3m is inclined rearward in the axial direction E from the inner portion where the proximal end surface 3g is substantially the same diameter as the outer peripheral surface 2g of the distal end in the axial direction E toward the outer side in the radial direction. Is formed.
- the proximal end 3k in the axial direction E that becomes the outer circumferential end portion of the proximal end surface 3m is formed at an acute angle by the outer circumferential surface on the proximal end side in the axial direction E of the distal end portion 3 and the proximal end surface 3m. . That is, the base end 3k is formed as an acute edge portion.
- the base end 3k functions as a sample collection unit that collects a sample of a test site in the test sample.
- the specimen collection part may be separated from the base end 3k, and the specimen collection part may be fixed to the base end 3k by bonding or insert molding.
- the tip surface 3s at the tip in the axial direction of the tip 3 is formed in a curved surface, for example.
- the tip 3 has a substantially bullet-shaped cross section.
- tip part 3 is integrally formed with the main-body part 2 in this Embodiment.
- the outer periphery of the main body 2 is covered with a sheath portion 5 that is larger in diameter than the main body 2 along the axial direction E and whose outer diameter is substantially equal to the outer diameter of the distal end portion 3 in the axial direction E. Yes. Since the sheath portion 5 is inserted into a subject having a plurality of curved portions, the sheath portion 5 is formed of a resin having flexibility and biocompatibility in order to ensure insertability. In addition, as resin which comprises the sheath part 5, polyethylene, a fluororesin, PEEK, etc. are mentioned. Further, on the distal end side in the axial direction E of the sheath portion 5, a portion facing the ultrasonic observation portion 13 has ultrasonic permeability.
- the sheath portion 5 accommodates the main body portion 2 so as to be movable back and forth in the axial direction E, and as shown in FIGS. 1 to 3, the distal end surface 5m of the distal end in the axial direction E has a sheath portion. It is formed in the inclined surface which inclines in the back of the axial direction E as it goes to the inner side of radial direction from the outer peripheral surface of the part 5. As shown in FIG.
- the distal end 5s in the axial direction E that becomes the outer peripheral end portion of the distal end surface 5m is formed at an acute angle by the outer peripheral surface on the distal end side in the axial direction E of the sheath portion 5 and the distal end surface 5m. That is, it is formed as an acute edge portion.
- the tip 5s functions as a sample collecting unit that collects a sample of a test site in the test sample.
- the sample collection part may be separated from the tip 5s, and only the sample collection part may be fixed to the tip 5s by bonding or insert molding.
- the sample collection unit is shown to be the proximal end 3k of the distal end portion 3 and the distal end 5s of the sheath portion 5 or provided at the proximal end 3k and the distal end 5s. It may be provided on either one of 5s itself or on either one.
- a sample collection port 150 (see FIG. 2), which will be described later, is closed.
- a sample collection port 150 is opened between the proximal end 3k and the distal end 5s as shown in FIG.
- the sample collection port 150 is inserted into a narrowed portion 81k (see FIG. 8) of a lumen (for example, lung peripheral bronchus) 81 formed by a lesioned portion 85 where the ultrasonic probe system 1 becomes a test site in the subject.
- a lumen for example, lung peripheral bronchus
- the ultrasonic probe system 1 becomes a test site in the subject.
- the sample collection port 150 in which the tip 5s abuts on the base end 3k is in the closed state.
- the specimen is sandwiched between the distal end 5s and the proximal end 3k, and the distal end 5s A part of the specimen is cut by at least one of the proximal end 3k.
- the sheath portion 5 is formed to have a larger diameter than the main body portion 2, so that a space 8 is formed between the inner peripheral surface 5 n of the sheath portion 5 and the outer peripheral surface 2 g of the main body portion 2. Is formed. Note that the space 8 is filled with, for example, physiological saline, which is an ultrasonic transmission medium, from a base 25 (see FIG. 4) described later.
- the physiological saline leaks from the space 8, but instead enters the space 8 when mucus or the like in the subject enters.
- the functioned liquid functions as an ultrasonic transmission medium.
- the radial interval in the space 8 is narrow, that is, when the interval between the outer peripheral surface 2g of the body portion 2 and the inner peripheral surface 5n of the sheath portion 5 in the radial direction is narrow, outside the subject.
- physiological saline may be injected from the sample collection port 150 into the space 8 using capillary action.
- a hydrophilic treatment is applied to the outer peripheral surface 2g of the main body 2 and the inner peripheral surface 5n of the sheath portion 5, a capillary phenomenon easily occurs.
- a specimen having a predetermined length from the distal end 5s of the sheath portion 5 along the axial direction E and collected by at least one of the proximal end 3y and the distal end 5s is accommodated.
- An accommodating portion 8y is provided.
- part of the outer peripheral surface 2g of the main-body part 2 which faces the accommodating part 8y is surface-treated so that hydrophobicity may become higher than the other site
- the part of the outer peripheral surface 2g of the main body 2 facing the housing part 8y may have a higher contact angle than the other part of the outer peripheral surface 2g of the main body 2 and the inner peripheral surface 5n of the sheath part 5. Absent.
- a hydrophobic coating is applied to a portion of the outer peripheral surface 2g of the main body 2 facing the accommodating portion 8y, and other portions of the outer peripheral surface 2g of the main body 2 and the inner peripheral surface of the sheath portion 5 are applied. 5n may be provided with a hydrophilic coating.
- examples of the hydrophobic coating include coating using a fluorine-based coating material
- examples of the hydrophilic coating include bio-inspired, PEG, and other hydrophilic polymer coatings.
- the outer peripheral surface of the main body 2 facing the housing portion 8y is formed by forming only the portion of the outer peripheral surface 2g of the main body 2 facing the housing portion 8y with a fluororesin such as PTFE or PE without coating.
- the 2g portion may be made more hydrophobic than the other portions on the outer peripheral surface 2g of the main body 2 and the inner peripheral surface 5n of the sheath portion 5.
- part of the outer peripheral surface 2g of the main-body part 2 which faces the accommodating part 8y has hydrophobicity rather than the other site
- FIG. Since the specimen is mainly composed of lipid, it tends to adhere to the hydrophobic material. That is, it becomes easy to adsorb to the portion of the outer peripheral surface 2g of the main body 2 facing the housing portion 8y.
- the specimen is adsorbed to the site of the outer peripheral surface 2g of the main body 2 facing the accommodation section 8y, the specimen is accommodated in a state of being adsorbed facing the specimen collection port 150.
- the sample can be easily taken out via the sample collection port 150 with tweezers or the like.
- the housing portion 8y specifically, the distal end surface 5m of the sheath portion 5 and the distal end side in the axial direction E of the inner peripheral surface 5n are axially extended from the distal end 5s of the sheath portion 5.
- the blade part 7 cuts, for example, a ring-shaped specimen housed in the housing part 8y, for example, by making the specimen into a C-shape, for example, after operation, the tweezers etc. from the housing part 8y via the specimen collection port 150 This makes it easier to remove the specimen.
- the sample collected by being sandwiched between the proximal end 3k and the distal end 5s is accommodated in a ring shape in the accommodating portion 8y. Therefore, if the sample remains in the ring shape, the sample collection port 150 is postoperatively operated. This is because it becomes difficult to take out the specimen through the. Alternatively, if the sample remains in a ring shape, the sample must be cut with a scissors or the like while the sample is held with tweezers, and the removal operation becomes complicated.
- the blade part 7 may be provided with two or more along the circumferential direction of the accommodating part 8y. Absent.
- the operation member 21 of the main body 2 that moves the main body 2 back and forth in the axial direction E inside the sheath 5 is fixed to the main body 2 by bonding or welding.
- the position of the operation member 21 shown in FIG. 4 indicates the position where the sample collection port 150 where the proximal end 3k and the distal end 5s shown in FIG.
- the operation member 21 is a member that is located outside the subject and is operated by the examiner when the ultrasonic probe system 1 is inserted into the subject.
- the proximal end of the operation member 21 in the axial direction E is An operation finger hook 22 on which an examiner's finger is hooked is provided.
- the finger hook 22 may be provided integrally with the operation member 21, or may be a separate body and fixed to the operation member 21.
- the operation member 23 of the sheath portion 5 is fixed to the outer periphery of the proximal end of the sheath portion 5 by adhesion or welding.
- the operation member 23 is a member that is positioned outside the subject and is operated by the examiner when the ultrasonic probe system 1 is inserted into the subject, and is a member that moves the sheath portion 5 back and forth in the axial direction E. It is.
- an operation finger hook 24 on which an examiner's finger is hooked is provided at the proximal end in the axial direction E of the operation member 23.
- the finger hook 24 may be provided integrally with the operation member 23 or may be a separate body and fixed to the operation member 23 by adhesion, welding, screwing, or the like.
- the operation member 23 is operated in a radial direction at a position in front of the axial direction E relative to the position where the finger hook 24 is provided on the proximal end side in the axial direction E of the operation member 23 and a position rearward in the axial direction E from the proximal end of the sheath portion 5.
- a through hole 23 h that penetrates the member 23 is formed.
- the through hole 23 h is provided with a base 25 that supplies fluid to the space 8 through the through hole 23 h or discharges fluid from the space 8.
- the base 25 has, for example, a luer base shape.
- a fluid supply device is attached to the base 25 when supplying the above-described physiological saline to the space 8 or when supplying a liquid or gas to the space 8 when removing the specimen from the storage portion 8y.
- the sample collection port 150 is opened to facilitate entry of the sample into the storage unit 8y by reducing the pressure in the space 8, or when the sample stored in the storage unit 8y is aspirated and taken out through the base 25 A suction device is attached.
- an O-ring 27 is provided between the inner peripheral surface on the proximal end side in the axial direction E of the operation member 23 and the outer peripheral surface of the operation member 21 behind the through hole 23 h in the axial direction E. Yes.
- the O-ring 27 is a member that prevents the fluid in the space 8 from being discharged from the proximal end side in the axial direction E of the operation member 23 and prevents the outside liquid from entering the space 8 unexpectedly. It is.
- a retaining member 28 of a ring-shaped O-ring 27 is fixed to the operating member 23 by screwing, bonding, press-fitting or the like on the inner peripheral surface of the base end in the axial direction E of the operating member 23.
- a convex portion 28 t is provided on the inner peripheral surface 28 n of the retaining member 28, and at a position facing the convex portion 28 t on the outer peripheral surface 21 g of the operation member 21, as shown in FIG. 6.
- Two concave portions 21p and 21q that are spaced apart along the axial direction E and into which the convex portion 28t can be fitted may be provided.
- the sample collection port 150 whose base end 3k abuts on the distal end 5s is closed.
- the operation member 21, that is, the main body 2 is fixed at a position where the state is reached.
- the operation member 21, that is, the main body portion is located at a position where the sample collection port 150 where the proximal end 3k is separated from the distal end 5s is opened. 2 is fixed.
- FIG. 8 schematically shows a state in which an ultrasound probe system is inserted into one lumen having a narrowed portion due to a lesioned portion and the other lumen having no lesioned portion at a branching portion of the lung in a subject.
- the examiner inserts the main body portion 2 along the axial direction E into the sheath portion 5 from the distal end side in the axial direction E of the sheath portion 5 outside the subject. Note that this operation may be substituted by covering the outer periphery of the main body portion 2 with the sheath portion 5 along the axial direction E from the proximal end side in the axial direction E of the main body portion 2.
- work may be performed from the nozzle
- the examiner closes the sample collection port 150 shown in FIG. 1, in which the distal end 5 s is in contact with the proximal end 3 k by fitting the retaining member 28 into the recess 21 p of the operation member 21.
- the position of the body portion 2 in the axial direction E with respect to the sheath portion 5 is fixed.
- the examiner uses the ultrasonic probe system 1 to collect a small-diameter peripheral lung specimen that cannot be inserted by the insertion portion 122a of the endoscope 122
- the examiner uses the insertion portion 122a of the endoscope 122.
- the operation part 122b of the endoscope 122 (FIG. 20) is inserted into the treatment instrument insertion channel of the insertion part 122a of the endoscope 122.
- the ultrasonic probe system 1 is inserted from the distal end side in the axial direction E through the treatment instrument insertion port 122e (see FIG. 20) of the treatment instrument insertion channel provided in the reference).
- the examiner projects the distal end side in the axial direction E of the ultrasonic probe system 1 from the distal end opening of the insertion portion 122a of the treatment instrument insertion channel, and then, under X-ray observation, the ultrasonic probe system 1 While confirming the position of the distal end side in the axial direction E, as shown in FIG.
- the retaining member 28 is fitted into the recess 21p, that is, the positions of the main body 2 and the sheath 5 are fixed, the closed state of the sample collection port 150 is maintained. Since the proximal end 3k is in close contact with the distal end 5s, the wall surface of the lung peripheral bronchus 80 that comes into contact with at least the proximal end 3k and the distal end 5s comes into contact with the insertion of the ultrasonic probe system 1. One side is not shaved.
- the closed state of the sample collection port 150 is maintained, so that the peripheral lung bronchus 80 that comes into contact with the insertion of the ultrasonic probe system 1 is maintained.
- the wall surface of the pulmonary peripheral bronchus 80 is formed by the distal end 5s and the proximal end 3k. It is possible to prevent the shaving.
- the examiner After inserting the ultrasonic probe system 1 into the peripheral lung bronchus 80, the examiner searches for the lesioned part 85 while performing ultrasonic observation using the ultrasonic observation unit 13.
- the examiner from the observation image of the ultrasonic observation unit 13 shows that the distal end side in the axial direction E of the ultrasonic probe system 1 is a tube without a lesioned part 85 from the branch of the peripheral lung bronchus 80.
- the distal end side in the axial direction E of the ultrasonic probe system 1 is removed from the lumen 82 and inserted into another lumen 81.
- the distal end side in the axial direction E of the ultrasonic probe system 1 is located at the center of the lesioned part 85 from the branch of the lung peripheral bronchus 80 as shown in FIG.
- the examiner can recognize that the narrowed portion 81k has been inserted into the lumen 81 formed by the portion 85, the examiner can detect the axial direction of the ultrasonic probe system 1 approximately 1 cm before the center of the lesioned portion 85. Position the tip of E.
- the inspector moves the main body 2 from the position shown in FIG. 6 to the position shown in FIG.
- the narrowed portion 81k is expanded in diameter by the distal end portion 3, and the base end 3k that has been in contact with the distal end 5s moves forward in the axial direction E as shown in FIG.
- the mouth 150 is opened.
- the narrowed portion 81k is formed in the lumen 81 in which the lesioned portion 85 is formed along with the opening of the sample collecting port 150, a part of the lesioned portion 85 is connected to the main body via the sample collecting port 150.
- the portion 2 is introduced into the sheath portion 5 to the vicinity of the vicinity of the outer peripheral surface 2g on the distal end side in the axial direction E.
- the suction device is attached to the base 25 and the space 8 is decompressed, a part of the lesioned portion 85 is more likely to enter the sheath portion 5 more reliably.
- the ultrasonic observation unit 13 also moves about 1 cm forward in the axial direction E, but the lesioned part 85 may have 2 cm or more in the axial direction E. Therefore, the ultrasonic observation unit 13 does not lose sight of the lesioned part 85 as it moves.
- the examiner confirms that the lesioned part is drawn from the observation image, and then adjusts the position of the main body part 2 or the sheath part 5 in the axial direction E as necessary while observing with the ultrasonic observation part 13. To do.
- the main body part 2 is moved back and forth in the axial direction E, or the sheath part 5 is moved back and forth in the axial direction E using the operation member 23.
- At least one of the distal end 5s and the proximal end 3k allows the living tissue of the lesioned part 85 to be accommodated as a specimen in the accommodating part 8y via the specimen collection port 150.
- the specimen can be more easily accommodated in the accommodating portion 8y. If the space 8 is decompressed, the amount of sample collected can be increased, and the sample can be collected even for a bronchi having a slightly larger lumen.
- a part of the ring-shaped specimen accommodated in the accommodating portion 8y is cut at the blade portion 7, and becomes, for example, C-shaped.
- the specimen is accommodated in the outer peripheral surface 2g of the main body 2 if, for example, the hydrophobic coating is applied to the portion of the outer peripheral surface 2g of the main body 2 facing the accommodating portion 8y in the accommodating portion 8y as described above. It is adsorbed on the part facing the part 8y.
- the examiner moves the main body 2 rearward in the axial direction E until the retaining member 28 is fitted into the recess 21p, and pulls out the ultrasonic probe system 1 from the treatment instrument insertion channel of the endoscope 122. . That is, it is pulled out of the subject.
- the examiner moves the main body 2 again to the front in the axial direction E or moves the sheath 5 to the rear in the axial direction E, as shown in FIG.
- the sample accommodated in the accommodation portion 8 y on the outer peripheral surface 2 g of the main body 2 and cut by the blade portion 7 is taken out via the sample collection port 150 using tweezers or the like.
- the specimen may be removed not only by dropping the specimen into the liquid by immersing the tip end side in the axial direction E of the ultrasonic probe system 1 into the liquid, but also by removing the liquid from the base 25 into the space 8. It may be performed by supplying, or may be performed by sucking from the base 25 through the space 8.
- the examiner moves the main body portion 2 rearward in the axial direction E or moves the sheath portion 5 forward in the axial direction E until the retaining member 28 is fitted into the recess 21p after the sample is taken out.
- the base end 3k is brought into contact with the tip 5s. That is, the sample collection port 150 is closed as shown in FIG.
- the main body part 2 is moved back and forth in the axial direction E, or the sheath part 5 is moved in the axial direction E. It was shown that the specimen of the lesioned part 85 can be collected using at least one of the proximal end 3k of the distal end part 3 and the distal end 5s of the sheath part 5 by moving back and forth.
- the specimen of the lesioned part 85 can be collected reliably and with high positional accuracy.
- the blade portion 7 for cutting the specimen accommodated in the accommodating portion 8y is provided in the accommodating portion 8y.
- the part of the outer peripheral surface 2g of the main body 2 facing the housing part 8y is shown to be more hydrophobic than the other part of the outer peripheral surface 2g of the main body 2 and the inner peripheral surface 5n of the sheath part 5. .
- the specimen accommodated in the accommodating part 8y is cut by the blade part 7, and the specimen is adsorbed to the part of the outer peripheral surface 2g of the main body part 2 facing the accommodating part 8y.
- a sample can be easily collected from the storage portion 8y via the sample collection port 150.
- the reliability of the diagnosis of the lesion is improved and the examination time is shortened and reexamination is not required, which not only reduces the burden on the examiner and the subject, but also selects an appropriate treatment method. Is possible.
- the ultrasonic probe system 1 having a configuration capable of collecting a specimen at a test site during ultrasonic observation and easily taking out the collected specimen.
- FIG. 9 is a partial cross-sectional view of the distal end side in the axial direction of the ultrasonic probe system showing a configuration in which the distal end portion is detachable from the main body portion of FIG.
- the tip portion 3 is formed integrally with the main body portion 2. Not only this but the front-end
- tip part 3 may be provided in the main body part 2 and the different body.
- a small diameter portion 2 w having a screw 2 r formed on the outer peripheral surface is formed at the distal end in the axial direction E of the main body portion 2, and the small diameter portion is formed at the distal end portion 3.
- a groove 3x along the axial direction E into which 2w can be inserted is formed in the center of the tip 3 in the radial direction, and a screw groove 3r is formed in which the screw 2r is screwed onto the inner peripheral surface of the groove 3x.
- a rotation groove 3v for rotating the tip portion 3 is formed on the outer peripheral surface of the tip portion 3 in order to fix the tip portion 3 to the small diameter portion 2w.
- the small diameter portion 2w is inserted into the concave groove 3x, the tip portion 3 is rotated in one direction using the rotation groove 3v, and the screw 2r is screwed into the screw groove 3r.
- the tip 3 can be attached to the tip. Further, the tip 3 can be removed from the tip in the axial direction E of the main body 2 simply by rotating the tip 3 in the other direction using the rotation groove 3v and removing the small diameter portion 2w from the groove 3x.
- the distal end portion 3 having the proximal end 3k for collecting the sample can be removed from the main body portion 2 and the distal end portion 3 is removed, the outer surface of the main body portion 2 is cleaned, disinfected, Since it becomes possible to sterilize, the main-body part 2 can be utilized again.
- a plurality of types of distal end portions 3 having different base end 3k angles can be attached to the main body portion 2 in accordance with the purpose.
- FIG. 10 is a partial cross-sectional view showing the distal end side in the axial direction of the ultrasonic probe system of the present embodiment with the sample collection port closed, and FIG. 11 shows ultrasonic waves with the sample collection port of FIG. 10 open. It is a fragmentary sectional view which shows the front end side of the axial direction of a probe system.
- FIG. 12 shows a modification in which a step portion is provided at a portion of the inner peripheral surface facing the housing portion of the sheath portion of FIG. 10 on the distal end side in the axial direction of the ultrasonic probe system in which the sample collection port is closed.
- FIG. 13 is a partial cross-sectional view
- FIG. 13 is a partial cross-sectional view showing a distal end side in the axial direction of the ultrasonic probe system when the sample collection port of FIG. 12 is open
- FIG. 14 is provided at the proximal end of the ultrasonic probe system of FIG. It is a fragmentary sectional view which shows schematically the formed connector.
- the configuration of the ultrasonic probe system according to the second embodiment is such that the ultrasonic observation unit 33 is provided in the main body 2 as compared with the ultrasonic probe system according to the first embodiment shown in FIGS. The difference is that it is provided so as to be movable back and forth in the axial direction.
- an ultrasonic image is obtained in the subject 2 by transmitting ultrasonic waves in the side surface direction S of the main body 2.
- a sound wave observation unit 33 is provided so as to be movable back and forth in the axial direction E.
- the ultrasonic observation unit 33 is provided at the tip in the axial direction E of the ultrasonic probe 31 that is housed in the interior 2 i of the main body 2 so as to be movable in the front and rear directions in the axial direction E. That is, the ultrasonic probe 31 having the ultrasonic observation unit 33 is provided unfixed to the main body unit 2.
- the ultrasonic probe 31 is composed of a mechanical radial scanning probe.
- the ultrasonic probe 31 includes an ultrasonic observation unit 33 including a single-plate ultrasonic transducer, a housing 36 that holds the ultrasonic observation unit 33, and an ultrasonic observation unit 33.
- An electrical pulse signal from an ultrasonic observation device 123 (see FIG. 20), which will be described later, is transmitted to an ultrasonic observation unit 33 that extends to the connector 40 (see FIG. 14), which will be described later, from the rear in the axial direction E.
- the ultrasonic probe 31 includes a flexible shaft 35 that includes the ultrasonic transducer cable 15 and extends rearward in the axial direction E from the housing 36.
- the flexible shaft 35 applies rotational power to the housing 36. That is, the ultrasonic observation unit 33 rotates together with the housing 36 by the rotational power from the flexible shaft 35.
- the base end of the flexible shaft 35 in the axial direction E is a connector 40 provided at the base end of the ultrasonic probe system 1 in the axial direction E, for example, in a connector cover 48 made of resin.
- the rotation transmission shaft 44 and the fixed pin 47 are connected to the connector main body 49 via a bearing 46 that is prevented from being detached from the connector cover 48.
- the electrical connector 51 and the rotation transmission pin 52 extending from the connector main body 49 are ultrasonic waves.
- a rotational driving force is transmitted from a drive source provided in the ultrasonic observation device 123.
- the connector body 49 is fixed to the connector cover 48 by fixing pins 47.
- a noise reducing shield cover 50 made of metal such as stainless steel or copper alloy is provided.
- the rotation transmission shaft 44 is in contact with the inner peripheral surface of the connector cover 48 via an O-ring 45, and a screw formed on the outer periphery on the distal end side in the axial direction E of the connector cover 48 is attached to a sheath fixing ring. 43 is rotatably screwed.
- a sheath fixing base 41 having a base end in the axial direction E of the main body 2 fixed thereto is provided inside the sheath fixing ring 43, and between the outer periphery of the sheath fixing base 41 and the inner periphery of the sheath fixing ring 43. Is provided with a rubber ring 42.
- the sheath fixing ring 43 compresses the rubber ring 42 in the radial direction as it rotates, and when the rubber ring 42 is compressed in the radial direction, the inner diameter becomes smaller and comes into contact with the outer peripheral surface of the sheath fixing base 41. Thereby, the position of the base end in the axial direction E of the main body 2 is fixed.
- the operation member 21 for moving the main body 2 forward and backward in the axial direction E and the sheath 5 in the axial direction E are used.
- the operation member 23 to be moved back and forth is provided in front of the connector 40 in the axial direction E at a midway position in the axial direction E of the ultrasonic probe system 1.
- the retaining member 28 provided in the operation member 23 is fitted into the recesses 21 p and 21 q provided in the operation member 21.
- the inside 2i of the main body 2 is filled with an ultrasonic transmission medium.
- the ultrasonic transmission medium filled in the interior 2i include sterilized water, distilled water, and liquid paraffin.
- the portion facing the housing portion 8 y is formed to be thinner in the radial direction than the other portions, so that the sheath portion 5 is formed on the inner peripheral surface 5 n.
- a step portion 5d having a predetermined length from the tip of each of them may be formed.
- the step portion 5d is formed at the portion of the inner peripheral surface 5n facing the accommodating portion 8y, the space 8 between the outer peripheral surface 2g of the main body portion 2 and the inner peripheral surface 5n of the sheath portion 5 is formed. 12 and FIG. 13, even if it is very narrow, the step 5d can secure a large specimen storage space.
- the above-described surface treatment that increases the hydrophobicity may be applied to the portion of the outer peripheral surface 2g of the main body 2 facing the inner peripheral surface 5n formed by the step portion 5d of the sheath portion 5.
- the part of the outer peripheral surface 2g of the main body part 2 facing the housing part 8y is more than the other part of the outer peripheral surface 2g of the main body part 2 not facing the housing part 8y and the inner peripheral surface 5n formed by the step part 5d.
- the contact angle may be high.
- the above-described hydrophobic coating is applied to the portion of the outer peripheral surface 2g of the main body portion 2 facing the housing portion 8y, and the other portion of the outer peripheral surface 2g of the main body portion 2 that does not face the housing portion 8y.
- the inner peripheral surface 5n formed by the step portion 5d of the sheath portion 5 may be provided with a hydrophilic coating.
- the outer peripheral surface of the main body 2 facing the housing portion 8y is formed by forming only the portion of the outer peripheral surface 2g of the main body 2 facing the housing portion 8y with a fluororesin such as PTFE or PE without coating.
- the 2g portion may be more hydrophobic than the other peripheral portion of the outer peripheral surface 2g of the main body 2 and the inner peripheral surface 5n formed by the step portion 5d of the sheath portion 5.
- the portion of the outer peripheral surface 2g of the main body 2 facing the housing portion 8y is more hydrophobic than the inner peripheral surface 5n formed by the other portion of the outer peripheral surface 2g of the main body 2 and the step portion 5d of the sheath portion 5. If it has the property, since the specimen has lipid as a main component, it easily adheres to the hydrophobic material. That is, the sample is easily adsorbed to the portion of the outer peripheral surface 2g of the main body 2 facing the storage portion 8y.
- step portion 5d may be formed on the inner peripheral surface 5n of the sheath portion 5 of the ultrasonic probe system 1 of the first embodiment described above.
- the portion facing the ultrasonic observation portion 33 has ultrasonic permeability.
- a blade 30 may be provided along the axial direction E in a portion where the ultrasonic wave transmitted from the ultrasonic observation unit 33 in the side surface direction S does not pass in the sheath portion 5. According to this, since the elasticity of the sheath part 5 in the axial direction E is lowered by the blade 30, as shown in FIGS. 10 and 12, when the sample collection port 150 is in the closed state, the shaft of the ultrasonic probe system 1 is closed. When the distal end side in the direction E is inserted to the lesioned part 85 in the pulmonary peripheral bronchus 80, the sample collection port 150 is prevented from opening unexpectedly.
- the inspector takes out the sheath part 5 and the main body part 2 from the sterilization pack, and fills the inside 2i of the main body part 2 with an ultrasonic transmission medium.
- the inspector inserts the ultrasonic probe system 1 into the inside 2i of the main body 2 and rotates the sheath fixing ring 43 (see FIG. 14), so that the axial direction E of the main body 2 is as described above. Fix the proximal end.
- the step of filling the space 8 with physiological saline the step of inserting the distal end side in the axial direction E of the ultrasonic probe system 1 to the pulmonary peripheral bronchus 80, the specimen of the lesioned portion 85, the proximal end 3k and the distal end 5s. Since the step of collecting the sample so as to be accommodated in the accommodating unit 8y and the step of extracting the sample accommodated in the accommodating unit 8y outside the subject after the collection are the same as those in the first embodiment described above, The description is omitted.
- the base end in the axial direction E of the main body 2 is shown in FIG.
- the main body portion 2 is more stretchable in the axial direction E than the sheath portion 5, so that as shown in FIG.
- the retaining member 28 is fitted into the recess 21p, and the proximal end 3k of the distal end portion 3 is in contact with the distal end 5s of the sheath portion 5 with pressure in the rear in the axial direction E (FIG. 6 corresponding to FIG. 4).
- the main body 2 extends forward in the axial direction E as the distal end 3 is pressed forward in the axial direction E by the distal end 5s of the sheath 5 as shown in FIG.
- the ultrasonic probe 31 has a body portion. 2 is moved to the rear in the axial direction E.
- the inspector removes the main body 2 and the sheath 5 after taking out the specimen from the container 8y. Thereafter, the ultrasonic probe 31 taken out from the inside 2i of the main body 2 is washed and then placed in a sterilization pack and sterilized.
- the ultrasonic probe 31 having the ultrasonic observation unit 33 is provided to be movable forward and backward in the axial direction E inside the main body 2. That is, the ultrasonic probe 31 having the ultrasonic observation part 33 is shown to be provided unfixed to the main body part 2.
- FIG. 15 is a partial cross-sectional view of the tip end side in the axial direction of the ultrasonic probe system showing a configuration of a modification example in which the blade portion 7 is removed from the housing portion 8y of the ultrasonic probe system 1 of FIG.
- the blade portion 7 may not be provided in the housing portion 8y. According to this, although it becomes difficult to take out the specimen accommodated in the accommodating part 8y, the same effects as those of the second embodiment described above can be obtained.
- FIG. 16 is an ultrasonic probe system showing a configuration of a modified example in which a plurality of grooves 5e along the axial direction are formed along the circumferential direction on the inner peripheral surface 5n of the sheath portion 5 of the ultrasonic probe system 1 of FIG.
- FIG. 17 is a sectional view of the sheath portion taken along the line XVII-XVII in FIG. 16.
- a plurality of grooves 5 e along the axial direction E may be formed along the circumferential direction on the inner circumferential surface 5 n of the sheath portion 5.
- the plurality of grooves 5e can smoothly move the sheath part 5 or the body part 2 in the axial direction E, and the space of the accommodating part 8y is larger than that of the present embodiment shown in FIG.
- the eccentricity of the sheath part 5 with respect to the main body part 2 can be suppressed as much as possible by the plurality of grooves 5e, so that it is possible to reliably collect a sample.
- Other effects are the same as those of the second embodiment described above.
- FIG. 18 is an axis of an ultrasonic probe system showing a configuration of a modified example in which a plurality of grooves 2e along the axial direction are formed along the circumferential direction on the outer peripheral surface 2g of the main body 2 of the ultrasonic probe system of FIG.
- FIG. 19 is a cross-sectional view of the sheath part and the main body part taken along line XIX-XIX in FIG.
- a plurality of grooves 2 e along the axial direction E may be formed along the circumferential direction on the outer circumferential surface 2 g of the main body 2.
- the plurality of grooves 2e can smoothly move the sheath portion 5 or the body portion 2 in the axial direction E, and the space of the accommodating portion 8y is larger than that of the present embodiment shown in FIG.
- the eccentricity of the sheath part 5 with respect to the main body part 2 can be suppressed as much as possible by the plurality of grooves 2e. This makes it possible to reliably collect a sample.
- the proximal end surface 3 m of the distal end portion 3 may be formed as a flat surface. That is, the base end 3k may not be formed at an acute angle. In this case, the proximal end 3k does not constitute a specimen collection unit.
- the tip 3 may be provided separately from the main body 2 as shown in FIG. 9 described above in the first embodiment.
- ultrasonic probe system 1 is used in an endoscope system as shown in FIG. 20, for example.
- FIG. 20 is a diagram schematically illustrating an endoscope system including the ultrasonic probe system according to the first and second embodiments.
- the endoscope 122 provided in the endoscope system 200 has a long flexible endoscope insertion portion 122a, and the proximal side of the endoscope insertion portion 122a. Is provided with an operation unit 122b.
- a universal cord 122c is extended from the operation portion 122b, and a scope connector 122d is provided at an end thereof.
- a video processor device and a light source device are connected to the scope connector 122d.
- a treatment instrument insertion port 122e is opened in the vicinity of the connecting portion between the endoscope insertion section 122a and the operation section 122b, and the above-described treatment instrument insertion channel is communicated with the treatment instrument insertion opening 122e.
- the treatment instrument insertion treatment instrument channel is formed in the endoscope insertion section 122a, and the distal end of the treatment instrument channel is opened to the distal end surface of the endoscope insertion section 122a.
- the connector 40 provided at the proximal end of the ultrasonic probe system 1 is connected to the connector receiving portion 123a of the ultrasonic observation device 123.
- the ultrasonic observation device 123 causes the monitor 124 to display the ultrasonic image obtained by the ultrasonic observation unit 13 (33).
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Abstract
Description
図1は、本実施の形態の超音波プローブシステムの軸方向の先端側を、検体採取口が閉状態にて示す部分断面図、図2は、図1の検体採取口が開状態における超音波プローブシステムの軸方向の先端側を示す部分断面図である。
図10は、本実施の形態の超音波プローブシステムの軸方向の先端側を、検体採取口が閉状態にて示す部分断面図、図11は、図10の検体採取口が開状態における超音波プローブシステムの軸方向の先端側を示す部分断面図である。
図20に示すように、内視鏡システム200に備えられている内視鏡122は長尺の可撓性を有する内視鏡挿入部122aを有し、この内視鏡挿入部122aの手元側に操作部122bが設けられている。
Claims (4)
- 棒状の本体部と、
前記本体部に設けられ、前記本体部の側面方向に超音波を送信し、反射波を受信する超音波観察部と、
基端側の面である基端面が前記本体部の軸方向の先端に隣接するように設けられ、前記本体部よりも大径の先端部と、
前記本体部よりも大径であり、前記本体部を前記軸方向に進退自在に内部に収容する筒形状のシース部と、
前記シース部の先端に配置され、前記基端面と対面する先端面と、
前記基端面および前記先端面の少なくとも一方に設けられ、被検体から円環状に検体を分離するために全周が軸方向に向けて鋭角な検体採取部と、
前記検体採取部により採取された円環状の前記検体を切断するため、前記検体採取部の前記全周に対して交差するように前記基端面または前記先端面に配置された刃部と、
を具備することを特徴とする超音波プローブシステム。 - 前記刃部は、前記先端面に形成されていることを特徴とする請求項1に記載の超音波プローブシステム。
- 前記本体部は、前記シース部よりも前記軸方向における伸縮性が高いことを特徴とする請求項1に記載の超音波プローブシステム。
- 前記本体部の前記外周面は、前記シース部の前記内周面よりも疎水性が高いことを特徴とする請求項1に記載の超音波プローブシステム。
Priority Applications (4)
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CN201380012174.3A CN104159522B (zh) | 2013-01-16 | 2013-12-05 | 超声波探头*** |
JP2014508411A JP5572781B1 (ja) | 2013-01-16 | 2013-12-05 | 超音波プローブシステム |
EP13871805.1A EP2803322A4 (en) | 2013-01-16 | 2013-12-05 | ULTRASONIC PROBE SYSTEM |
US14/199,251 US8991257B2 (en) | 2013-01-16 | 2014-03-06 | Ultrasound probe system |
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JP2013-005626 | 2013-01-16 | ||
JP2013005626 | 2013-01-16 |
Related Child Applications (1)
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US14/199,251 Continuation US8991257B2 (en) | 2013-01-16 | 2014-03-06 | Ultrasound probe system |
Publications (1)
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WO2014112238A1 true WO2014112238A1 (ja) | 2014-07-24 |
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ID=51209348
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PCT/JP2013/082725 WO2014112238A1 (ja) | 2013-01-16 | 2013-12-05 | 超音波プローブシステム |
Country Status (5)
Country | Link |
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US (1) | US8991257B2 (ja) |
EP (1) | EP2803322A4 (ja) |
JP (1) | JP5572781B1 (ja) |
CN (1) | CN104159522B (ja) |
WO (1) | WO2014112238A1 (ja) |
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WO2016039291A1 (ja) * | 2014-09-12 | 2016-03-17 | オリンパス株式会社 | 超音波内視鏡 |
JP7013249B2 (ja) * | 2018-01-16 | 2022-01-31 | オリンパス株式会社 | 超音波プローブ |
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-
2013
- 2013-12-05 JP JP2014508411A patent/JP5572781B1/ja active Active
- 2013-12-05 CN CN201380012174.3A patent/CN104159522B/zh active Active
- 2013-12-05 EP EP13871805.1A patent/EP2803322A4/en not_active Withdrawn
- 2013-12-05 WO PCT/JP2013/082725 patent/WO2014112238A1/ja active Application Filing
-
2014
- 2014-03-06 US US14/199,251 patent/US8991257B2/en active Active
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JPS62270140A (ja) * | 1986-02-28 | 1987-11-24 | カ−デイオヴアスキユラ− イメイジングシステムズ インコ−ポレ−テツド | 血管内の2次元超音波検査のためのカテーテル装置 |
JP2001104316A (ja) * | 1999-10-13 | 2001-04-17 | Asahi Optical Co Ltd | 内視鏡用組織採取具 |
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Also Published As
Publication number | Publication date |
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JPWO2014112238A1 (ja) | 2017-01-19 |
US8991257B2 (en) | 2015-03-31 |
EP2803322A4 (en) | 2015-10-21 |
CN104159522A (zh) | 2014-11-19 |
CN104159522B (zh) | 2016-03-09 |
JP5572781B1 (ja) | 2014-08-13 |
US20140238138A1 (en) | 2014-08-28 |
EP2803322A1 (en) | 2014-11-19 |
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