WO2012142678A1 - Weight loss composition - Google Patents
Weight loss composition Download PDFInfo
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- WO2012142678A1 WO2012142678A1 PCT/AU2012/000427 AU2012000427W WO2012142678A1 WO 2012142678 A1 WO2012142678 A1 WO 2012142678A1 AU 2012000427 W AU2012000427 W AU 2012000427W WO 2012142678 A1 WO2012142678 A1 WO 2012142678A1
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- WIPO (PCT)
- Prior art keywords
- composition
- vitamin
- composition according
- probiotic microorganisms
- subject
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Definitions
- compositions comprising one or more probiotic microorganisms, glutamine and at least one sugar alcohol and uses thereof for promoting weight and/or fat loss in a subject.
- the number of overweight and obese individuals has more than doubled over the past two decades.
- the health problems and consequences associated with overweight and obese individuals are many and varied, including type 2 diabetes, gall bladder disease, hypertension, dyslipidaemia, insulin resistance, musculoskeletal problems, cardiovascular disease, atherosclerosis, some cancers, sleep apnoea, breathlessness, asthma, social isolation/depression and daytime sleepiness/fatigue.
- Such health problems cause discomfort and pain and decrease the quality of life to the individual and are a costly clinical problem.
- Treatment of overweight or obese individuals includes diet and exercise regimes. Unfortunately not all individuals are able to diet and/or exercise effectively due to factors such as sedentary lifestyles, the ready availability of fast foods and convenience foods leading to poor dietary selection, lack of free time, stress and depression. As a result many individuals are unable to reduce their weight and/or maintain a healthy weight. Some individuals choose to undergo surgery in an attempt to lose weight, for example by undergoing surgery to reduce the size of the stomach or the length of the bowels. Unfortunately, complications from surgery are common and the individual is required to modify their behaviour towards food to enhance the likelihood of a successful outcome.
- compositions that promotes weight loss and/or fat loss in an individual.
- the present inventors have found that a composition comprising one or more probiotic microorganisms, giutamine and at least one sugar alcohol promotes weight loss and/or fat loss in an individual.
- composition comprising one or more probiotic microorganisms, giutamine and at least one sugar alcohol.
- composition comprising one or more probiotic microorganisms, giutamine and at least one sugar alcohol for promoting weight loss and/or fat loss in a subject.
- composition according to the first or second aspect may further comprise vitamin K.
- the one or more probiotic microorganisms comprises Lactobacillus and/or Bifidobacterium.
- the probiotic microorganisms comprise Lactobacillus acidophilus.
- the probiotic microorganisms comprise Bifidobacterium lactis.
- the probiotic microorganisms comprises Lactobacillus acidophilus and Bifidobacterium lactis.
- the probiotic microorganisms in the composition may be in an amount of from about 1 billion to about 50 billion lU/mg. In one embodiment the probiotic microorganisms in the composition are in an amount of about 3 billion lU/mg.
- the giutamine in the composition may be in an amount of from about 50 to about 600 lU/mg. In one embodiment the giutamine in the composition is in an amount of about 250 lU/mg.
- the at least one sugar alcohol is xylitol, mannitol or sorbitol. In particular embodiments the at least one sugar alcohol is xylitol.
- the xylitol in the composition may be in an amount of from about 10 to about 300 g/kg. In one embodiment the xylitol in the composition is in an amount of about 110 g/kg.
- the composition further comprises vitamin K.
- the vitamin K may be vitamin K1 and/or vitamin K2.
- the vitamin K in the composition may be in an amount of from about 0.1 pg/mg to about 100 pg/mg. In one embodiment the vitamin K in the composition is in an amount of about 1 pg /mg.
- composition further comprises vitamin D.
- composition further comprises whey protein.
- composition further comprises vitamin B.
- composition further comprises polydextrose.
- composition further comprises at least one medium chain triglyceride.
- composition further comprises one or mqre enzyme.
- the enzyme may be selected from the group consisting of protease, bromelain and papain.
- the composition is in a form suitable for oral administration.
- the composition is in the form of a liquid, a powder or a unit dosage form such as a tablet, capsule or caplet.
- a method of promoting weight loss and/or fat loss in a subject comprising administering to the subject a composition comprising one or more probiotic microorganisms, glutamine and at least one sugar alcohol.
- composition is typically administered to the subject orally.
- the composition is in the form of a liquid, a powder or a unit dosage form.
- the unit dosage form may be a tablet, a capsule or a caplet. Typically between 1 and 5 unit dosage forms are administered per day.
- a method of promoting a healthy immune system in a subject comprising administering to the subject a composition comprising one or more probiotic microorganisms, glutamine and at least one sugar alcohol.
- the composition is typically administered to the subject orally.
- the composition is in the form of a liquid, a powder or a unit dosage form.
- the unit dosage form may be a tablet, a capsule or a caplet. Typically between 1 and 5 unit dosage forms are administered per day.
- the oral composition as defined above may be in the form of a food stuff or beverage, or suitable for administering with a food stuff or beverage.
- composition comprising one or more probiotic microorganisms, glutamine and at least one sugar alcohol in the manufacture of a medicament for promoting weight loss and/or fat loss in a subject.
- composition comprising one or more probiotic microorganisms, glutamine and at least one sugar alcohol in the manufacture of a medicament for promoting a healthy immune system in a subject.
- an element means one element or more than one element.
- sucrose alcohol or “sugar alcohols” is understood to refer to those compounds with the general formula H(HCHO) n+ iH and which can be administered to a subject. A person skilled in the art will appreciate that the term does not include the sugar alcohol glycol.
- probiotic microorganisms is to be given its broadest construction and is understood to refer to any live microorganisms which when administered in an effective amount promotes a health benefit.
- prebiotic is to be given its broadest construction and is understood to refer to any non-digestible substance that stimulates the growth and/or activity of bacteria, in particular probiotic bacteria, in the digestive system.
- the terms “promote” and “promoting” and variations thereof as used herein refer to the ability of a composition of the present disclosure to achieve or assist in achieving a benefit, either directly or indirectly, in relation to weight loss and/or fat loss, the health of the gastrointestinal tract, the health of the immune system and/or diseases associated therewith; or to improve the ability to achieve or assist in achieving a measurable benefit, either directly or indirectly, in relation to weight loss and/or fat loss, the health of the gastrointestinal tract, the health of the immune system and/or diseases associated therewith; or otherwise prevent, hinder, retard, or reverse the deterioration in the health of a subject in any way whatsoever.
- promote promote
- a derivative of vitamin D 3 is understood to include compounds that are formed from a parent compound by chemical reaction(s).
- a derivative of vitamin D 3 is a compound formed by a chemical reaction with vitamin D 3 .
- precursors or precursors
- a precursor of vitamin D 3 forms vitamin D 3 via chemical reaction(s) or metabolic process(es).
- “food”, “foods”, “beverage” or “beverages” includes but is not limited to health foods, functional foods and foods for specified health use. When such food or beverage of the present disclosure is used for subjects other than humans, the term can be used to include a feedstuff.
- the term “subject” includes humans, primates, livestock animals (eg. sheep, pigs, cattle, horses, donkeys), laboratory test animals (eg. mice, rabbits, rats, guinea pigs), companion animals (eg. dogs, cats) and captive wild animals (eg. foxes, kangaroos, deer). Typically, the subject is a human or a laboratory test animal. Even more typically, the subject is a human.
- Embodiments of the present disclosure provide compositions comprising one or more probiotic microorganisms, glutamine and at least one sugar alcohol.
- the compositions promote weight loss and/or fat loss in a subject.
- the compositions may be used as meal replacements or alternatively in addition to meals as part of a calorie controlled diet/weight loss regime.
- compositions of the disclosure are also useful for managing diseases and/or disorders that are associated with excessive calorie intake, such as obesity, metabolic syndrome and diseases and conditions related thereto.
- compositions may promote a healthy immune system thereby reducing the risk of autoimmune disease, reducing inflammation, and promoting the health of the gastrointestinal tract thereby promoting healthy digestion and absorption of nutrients in a subject.
- compositions may promote an improved mood state and/or boost the metabolism and assist in balancing the appetite of a subject.
- compositions may promote the health of a subject by reducing the risk of hypothyroidism.
- compositions of the present disclosure may also assist in reducing or inhibiting bone decay in a subject, thereby decreasing the pain associated with the effects of carrying extra weight.
- compositions of the present disclosure seek to not only address the issue of weight loss and or fat loss but also to reduce systematic inflammation and stress in the gastrointestinal tract thereby promoting an improvement in the health of the gastrointestinal tract, promoting weight loss and/or fat loss and promoting additional health benefits.
- Compositions comprising one or more probiotic microorganisms, glutamine and at least one sugar alcohol work synergistically promoting bacterial growth in the gut because the glutamine and at least one sugar alcohol nourish the probiotic microorganisms during proliferation.
- BMI Body Mass Index
- compositions may reduce systemic inflammation and promote the health of the gastrointestinal tract and therefore assist in preventing and/or promoting the improvement of conditions associated with systemic inflammation.
- Dysbiosis is a condition that causes microbial imbalances on or within the body.
- Dysbiosis can cause major problems in the gastrointestinal tract or on the skin, and has been associated with inflammatory bowel disease, chronic fatigue syndrome, poor oestrogen clearance and compromised digestion which can reduce the absorption of nutrients.
- Dysbiosis can also lead to leaky gut and can comprise vitamin K in a subject.
- the probiotic microorganisms in accordance with embodiments of the present disclosure may reduce dysbiosis thereby promoting absorption of B vitamins and vitamin K.
- the compositions of the present disclosure may comprise any one or more probiotic microorganisms.
- the one or more probiotic microorganisms may be present in the composition as specially selected strains as a culture concentrate or as part of a multiple strain blend with a variety of excipients.
- the one or more probiotic microorganisms may include but are not limited to one or more of a strain of Lactobacillus, Bifidobacterium, Streptococcus Saccharomyces, Bacillus, Enterococcus, Bacteroides or Propionibacterium.
- the Lactobacillus may be one or more of, but is not limited to, Lactobacillus acidophilus, Lactobacillus bulgaricus, Lactobacillus rhamnosus, Lactobacillus bulgaricus, Lactobacillus salivarius, Lactobacillus plantarum, Lactobacillus casei, Lactobacillus helveticus, Lactobacillus reuteri, Lactobacillus johnsonii, Lactobacillus paracasei, Lactobacillus gasseri or Lactobacillus sporogenes.
- the Lactobacillus is Lactobacillus acidophilus.
- the Bifidobacterium may be one or more of, but is not limited to, Bifidobacterium animalis, Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium infantis, Bifidobacterium Lafti, Bifidobacterium breve or Bifidobacterium lactis. In one embodiment the Bifidobacterium is Bifidobacterium lactis.
- the Streptococcus may be one or more of, but is not limited to, Streptococcus thermophilus, Streptococcus faecium, or Streptococcus salivarius.
- the Saccharomyces may be one or more of, but is not limited to, Saccharomyces cerevisiae or Saccharomyces boulardii.
- the Bacillus may be one or more of, but is not limited to, Bacillus coagulans, Bacillus cereus, Bacillus clausii, or Bacillus pumilus.
- the Enterococcus may be, but is not limited to, Enterococcus faecium.
- the amount of one or more probiotic microorganisms present in the compositions may be between about 1 billion to about 100 billion lU/mg, or more typically between about 2 billion to about 5 billion lU/mg.
- the composition may comprise about 2.5 billion lU/mg, 3.0 billion lU/mg, 3.5 billion lU/mg, 4.0 billion lU/mg or 4.5 billion lU/mg of the one or more probiotic microorganisms.
- the glutamine may be present in the composition in the form of a salt or derivative.
- the amount of glutamine present in the composition may be between about 1 lU/mg and about 1000 lU/mg, or more typically between about 50 lU/mg and about 600 lU/mg.
- the composition may comprise about 100 lU/mg, 150 lU/mg, 200 lU/mg, 250 lU/mg, 300 lU/mg, 350 lU/mg, 400 lU/mg, 450 lU/mg, 500 lU/mg or 550 of glutamine.
- compositions of the present disclosure comprise at least one sugar alcohol.
- the at least one sugar alcohol is typically selected from a sugar alcohol that also functions as a sweetener.
- the at least one sugar alcohol may include, but is not limited to, one or more of glycerol, erythritol, xylitol, mannitol, sorbitol, isomalt, maltitol, lactitol or polyglycitol.
- the at least one sugar alcohol is sorbitol.
- the at least one sugar alcohol is mannitol.
- the at least one sugar alcohol is xylitol.
- the xylitol may be present in the composition in the form of a salt or derivative.
- the amount of xylitol present in the composition may be between about 1 g/kg and about 1000 g/kg, or more typically between about 10 g/kg and about 300 g/kg.
- the composition may comprise about 20 g/kg, 30 g/kg, 40 g/kg, 50 g/kg, 60 g/kg, 70 g/kg, 80 g/kg, 90 g/kg, 100 g/kg, 110 g/kg, 120 g/kg, 130 g/kg, 140 g/kg, 150 g/kg, 160 g/kg, 170 g/kg, 180 g/kg, 190 g/kg, 200 g/kg, 210 g/kg, 220 g/kg, 230 g/kg, 240 g/kg, 250 g/kg, 260 g/kg, 270 g/kg, 280 g/kg or 290 g/kg of xylitol.
- the composition may further comprise vitamin K.
- the vitamin K may be vitamin Ki and/or vitamin K 2 .
- the vitamin K is vitamin K2.
- the vitamin K may be present in the form of suitable precursors, derivatives or analogues thereof.
- the body does not store vitamin K and therefore it is an essential vitamin that needs to be continuously ingested.
- Vitamin K 2 is produced by probiotics and some vegetables such as broccoli, however vitamin K 2 produced by probiotics is not always readily absorbed in the gut and the harmful bacteria in the gut does not permit vegetables to be digested effectively enough to ' extract sufficient vitamin K 2 from such foods.
- the one or more probiotic microorganisms in the compositions of the present disclosure harmonise the gut of an overweight or obese individual thereby allowing vitamin K to be more effectively extracted from food.
- the combination of one or more probiotic microorganisms and vitamin K (in particular vitamin K 2 ) in the compositions promote the proliferation of the beneficial bacteria and promote the absorption of vitamin K 2 .
- the amount of vitamin K present in the composition may be between about 0.1 Mg/mg and about 100 Mg/mg, or more typically between about 0.2 ⁇ /mg and about 5 ⁇ /mg w/w.
- the composition may comprise about 0.4 Mg/mg, 0.6 Mg/mg, 0.8 M /mg, 1.0 Mg/mg, 1.2 M /mg, 1.4 Mg/mg, 1.6 Mg/mg, 1.8 Mg/mg, 2.0 Mg/mg, 2,2 Mg/mg, 2.4 Mg/mg, 2.6 Mg/mg, 2.8 Mg/mg, 3.0 Mg/mg, 3.2 Mg/mg, 3.4 Mg/mg, 3.6.
- Fat cells can sequester vitamin D3 which can result in overweight and obese individuals suffering from vitamin D3 deficient related conditions, for example low bone density, inflammation, autoimmune diseases, poor immunity to colds and flu, depression, and cancer. Accordingly, in some embodiments vitamin D is added to the compositions to assist in replacing the vitamin D sequestered by fat cells.
- the vitamin D may be present as vitamin D 2 and/or D3.
- the compositions comprise vitamin D3 (cholecalciferol).
- the vitamin D3 may be in the form of any suitable precursor, derivative or analogue thereof;
- the composition comprises vitamin D 2 (ergocalciferol), or metabolites, analogues or derivatives thereof.
- compositions may further comprise a fibre and/or a prebiotic.
- compositions further comprise polydextrose which acts both as a source of a fibre and a prebiotic.
- the fibre and prebiotic may be inulin, fructooligosaccharides (FOS), xylooligosaccharides (XOS) and/or galactooligosaccharides (GOS).
- FOS fructooligosaccharides
- XOS xylooligosaccharides
- GOS galactooligosaccharides
- At least one enzyme such as but not limited to, protease (peptidase), bromelain and papain and/or at least one medium chain triglyceride (medium- chain (6 to 12 carbons) fatty acid esters of glycerol) may be added to the compositions.
- the at least one medium chain triglyceride may be selected from the group consisting of caproic acid (C6), caprylic acid (C8), capric acid (C10) and lauric acid (C12).
- C6 caproic acid
- C8 caprylic acid
- capric acid C10
- lauric acid C12
- a combination of at least one medium chain triglyceride and at least one enzyme in the compositions of the invention promotes the digestion of the at least medium chain triglyceride and ensures that the medium chain triglyceride is effectively utilised as energy thereby further promoting weight loss and/or fat loss.
- compositions may comprise protein.
- the protein may be whey protein, however a person skilled in the art will appreciate that other protein sources may also be used.
- the whey protein may be in the form of a concentrate, an isolate, and/or a hydrolysate.
- the whey protein is typically obtained from cow's milk, however those skilled in the art will appreciate that whey protein sourced from other milk may be used.
- the whey protein may comprise at least one of alpha iactalbumin, beta lactoglobulin, bovine serum albumin immunoglobulins and glycomacropeptides or mixtures thereof.
- compositions of the present disclosure may further comprise vitamins and/or minerals and/or amino acids.
- the vitamins and/or minerals may be one or more vitamins or minerals indicated for weight loss and/or appetite control.
- the vitamins and minerals may be selected from, but not limited to: vitamins A, Bi, B2, B 3 , B5, Be, B9, B12, C, D, E and calcium, chromium, copper, fluorine, iodine, iron, magnesium, manganese, molybdenum, phosphorus, potassium, selenium, sodium and zinc.
- amino acids may be selected from, but are not limited to: alanine, arginine, aspartic acid, cystine, glycine, histidine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan and tyrosine.
- compositions may be used as meal replacements or supplements. Alternatively, the compositions may form part of a calorie controlled diet. The methods and compositions of the disclosure may form part of a weight management program in a subject in need thereof. The compositions may be taken before, during, or after a meal and/or in between meals where necessary. In some embodiments the serving size of the composition may be between about 1 g and about 100 g, or between about 5 g and about 50 g, or between about 25 g and about 35 g, or about 26 g, 27 g, 28 g, 29 g, 30 g, 31 g, 32 g, 33 g or 34 g.
- compositions will depend on a number of factors such as the particular composition being administered, the age, body weight, general health, sex and dietary requirements of the subject, as well as any drugs or agents used in combination or coincidental with the compositions. Based on the teaching herein those skilled in the art will, by routine trial and experimentation, be capable of determining suitable dosage regimes on a case-by-case basis.
- compositions may be provided to the user, for example, in a liquid form, a powder form or as a solid unit dosage form such as a tablet, capsule or caplet.
- the compositions may be added in powder form by the user to any type of drink or food product (for example water, fruit juice or yoghurt) and consumed there after.
- the compositions may simply be consumed as a powder in the absence of a drink or additional food product.
- the composition may be conveniently presented and consumed in a dosage form prepared by any of the methods well known in the art.
- the method may include the step of bringing the components of the oral composition into association with a carrier which constitutes one or more accessory ingredients.
- oral compositions are prepared by uniformly and intimately bringing into association the components of the composition with a liquid carrier or finely divided solid carrier, or both and then, if necessary, shaping the product into the desired composition.
- composition may be conveniently incorporated in a variety of food and/or beverage products, nutraceutical products, pharmaceuticals and over-the- counter formulations.
- the food may be a solid form such as a powder, or a liquid form.
- beverages or foods include, but are not limited to water-based, milk-based, yoghurt-based, other dairy-based, milk-substitute based such as soy milk or oat milk, or juice-based beverages, water, soft drinks, carbonated drinks, and nutritional beverages, (including a concentrated stock solution of a beverage and a dry powder for preparation of such a beverage); baked products such as crackers, breads, muffins, rolls, bagels, biscuits, cereals, bars such as muesli bars, health food bars and the like, dressings, sauces, custards, yoghurts, puddings, prepackaged frozen meals, soups and confectioneries.
- compositions of the disclosure may be used in conjunction with other treatments directed to other diseases.
- the compositions of the invention may be used as part of a treatment regime or combination therapy, wherein the role of the composition is to promote weight loss and/or fat loss.
- the composition may be administered to a subject undergoing drug treatment for heart disease, wherein the composition assists in weight loss and/or fat loss.
- Example 1 Oral powder composition
- a typical powder composition for oral administration is prepared by combining the following components:
- Vitamin K 0.156 g/Kg (optional)
- alpha lactalbumin alpha lactalbumin, beta lactoglobulin, bovine serum albumin, immunoglobulins (IgG) and glycomacropeptides
- Vitamin A 0.060 g/Kg
- Vitamin Bi as thiamine hydrochloride
- Vitamin B 2 (as riboflavin) 0.027 g/Kg
- Vitamin BY (as nicotinamide) 0.156 g/Kg
- Vitamin Be (as pyridoxine hydrochloride) 0.030 g/Kg
- Vitamin B (as biotin) 0.047 g/Kg
- Vitamin B9 (as folic acid) 0.031 g/Kg
- Vitamin B12 0.003 g/Kg
- Vitamin C (ascorbic acid) 0.625 g/Kg
- Vitamin D3 0.016 g/Kg Vitamin E (d-alpha tocopheryl succinate) 0.189 g/Kg
- Chromium Chromium Pieolinate 2%) 0.318 g/Kg
- the dosage is 32 g of the resulting powder (typically dissolved in 200 mL water or other liquid) to be taken once to three times daily.
- Example 2 Oral powder composition
- An exemplary oral composition in accordance with the present disclosure comprises:
- Vitamin A 625.000 IU 1953.125 IU
- Vitamin D3 50.000 IU 156.250 IU
- Vitamin B12 (Cyanocobalamin) 1.000 meg 3.125 meg
- Pantothenic Acid (Vitamin B5) 0.800 mg 2.500 mg Ascorbic Acid 20,000 mg 62.500 mg
- Vitamin E 5.000 mg 15.625 mg
- Immunoglobulins (IgG) 586.000 mg 1831.250 mg
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Abstract
Description
Claims
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EP3513665A1 (en) * | 2018-01-23 | 2019-07-24 | Omega Pharma Innovation and Development NV | Dietary supplement and uses thereof |
CN111449183A (en) * | 2019-06-24 | 2020-07-28 | 广州维汝堂营养健康咨询有限公司 | Probiotic solid beverage with fat reducing function |
CN111254087A (en) * | 2019-12-27 | 2020-06-09 | 杭州娃哈哈科技有限公司 | Lactobacillus helveticus with high adhesion performance and function of enhancing immunity and application thereof |
CN111254087B (en) * | 2019-12-27 | 2021-12-17 | 杭州娃哈哈科技有限公司 | Lactobacillus helveticus with high adhesion performance and function of enhancing immunity and application thereof |
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