WO2012047017A3 - 2,3-dihydro-isoindol-1-one derivative and a composition comprising the same - Google Patents

2,3-dihydro-isoindol-1-one derivative and a composition comprising the same Download PDF

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Publication number
WO2012047017A3
WO2012047017A3 PCT/KR2011/007370 KR2011007370W WO2012047017A3 WO 2012047017 A3 WO2012047017 A3 WO 2012047017A3 KR 2011007370 W KR2011007370 W KR 2011007370W WO 2012047017 A3 WO2012047017 A3 WO 2012047017A3
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WO
WIPO (PCT)
Prior art keywords
composition
kinase activity
isoindol
dihydro
derivative
Prior art date
Application number
PCT/KR2011/007370
Other languages
French (fr)
Korean (ko)
Other versions
WO2012047017A2 (en
Inventor
홍용래
이미정
김정미
홍장원
장호진
박수봉
이휘성
최종류
노성구
조중명
Original Assignee
크리스탈지노믹스(주)
한국보건산업진흥원
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Application filed by 크리스탈지노믹스(주), 한국보건산업진흥원 filed Critical 크리스탈지노믹스(주)
Publication of WO2012047017A2 publication Critical patent/WO2012047017A2/en
Publication of WO2012047017A3 publication Critical patent/WO2012047017A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

The present invention relates to a pharmaceutical composition for the treatment, alleviation or prevention of diseases associated with abnormal or deregulated kinase activity, the composition comprising a compound represented by chemical formula 1 and a pharmaceutically acceptable salt, hydrate, prodrug or solvate thereof. The compound and composition of the present invention inhibit various types of protein kinase activity, and hence can be used to advantage in the treatment, alleviation or prevention of diseases associated with abnormal or deregulated kinase activity.
PCT/KR2011/007370 2010-10-05 2011-10-05 2,3-dihydro-isoindol-1-one derivative and a composition comprising the same WO2012047017A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38995010P 2010-10-05 2010-10-05
US61/389,950 2010-10-05

Publications (2)

Publication Number Publication Date
WO2012047017A2 WO2012047017A2 (en) 2012-04-12
WO2012047017A3 true WO2012047017A3 (en) 2012-05-31

Family

ID=45928221

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2011/007370 WO2012047017A2 (en) 2010-10-05 2011-10-05 2,3-dihydro-isoindol-1-one derivative and a composition comprising the same

Country Status (1)

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WO (1) WO2012047017A2 (en)

Families Citing this family (24)

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EP2918588B1 (en) 2010-05-20 2017-05-03 Array Biopharma, Inc. Macrocyclic compounds as TRK kinase inhibitors
US9758508B2 (en) * 2012-12-28 2017-09-12 Crystalgenomics, Inc. 2,3-dihydro-isoindole-1-on derivative as BTK kinase suppressant, and pharmaceutical composition including same
CN108349969B (en) 2015-07-16 2022-05-10 阵列生物制药公司 Substituted pyrazolo [1,5-a ] pyridine compounds as RET kinase inhibitors
KR101691954B1 (en) * 2016-04-26 2017-01-02 고려대학교 산학협력단 Novel N-acylurea Derivatives and Composition for Prevention or Treatment of Cardiovascular Disorders Comprising the Same
CN105906568A (en) * 2016-04-28 2016-08-31 西安交通大学 Cyclopropane diamide compound with antitumor activity and preparation method and application thereof
CN105924387A (en) * 2016-04-28 2016-09-07 西安交通大学 Diarylurea compound with antitumor activity, and preparation method and application thereof
CN105924403B (en) * 2016-04-28 2018-07-17 西安交通大学 A kind of ring propane diamide compound with anti-tumor activity and its preparation method and application
CN105859638B (en) * 2016-04-28 2018-07-17 西安交通大学 A kind of ring succinamide compound with anti-tumor activity and its preparation method and application
TWI704148B (en) 2016-10-10 2020-09-11 美商亞雷生物製藥股份有限公司 Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors
JOP20190077A1 (en) 2016-10-10 2019-04-09 Array Biopharma Inc Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors
WO2018136663A1 (en) 2017-01-18 2018-07-26 Array Biopharma, Inc. Ret inhibitors
JP6888101B2 (en) 2017-01-18 2021-06-16 アレイ バイオファーマ インコーポレイテッド Substituted pyrazolo [1,5-a] pyrazine compounds as RET kinase inhibitors
WO2018137959A1 (en) * 2017-01-25 2018-08-02 Basf Se Process for preparation of benzylic amides
KR20190128646A (en) * 2017-02-21 2019-11-18 압토스 바이오사이언시스 인코포레이티드 Treatment of patients with hematological tumors
JOP20190213A1 (en) 2017-03-16 2019-09-16 Array Biopharma Inc Macrocyclic compounds as ros1 kinase inhibitors
TWI812649B (en) 2017-10-10 2023-08-21 美商絡速藥業公司 Formulations of 6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile
TWI791053B (en) 2017-10-10 2023-02-01 美商亞雷生物製藥股份有限公司 Crystalline forms of 6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile and pharmaceutical composition thereof
WO2019134662A1 (en) * 2018-01-03 2019-07-11 南京明德新药研发股份有限公司 Heterocyclic compound as csf-1r inhibitor and use thereof
WO2019143994A1 (en) 2018-01-18 2019-07-25 Array Biopharma Inc. Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors
TWI802635B (en) 2018-01-18 2023-05-21 美商亞雷生物製藥股份有限公司 Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors
US11524963B2 (en) 2018-01-18 2022-12-13 Array Biopharma Inc. Substituted pyrazolo[3,4-d]pyrimidines as RET kinase inhibitors
JP2022500383A (en) 2018-09-10 2022-01-04 アレイ バイオファーマ インコーポレイテッド Condensed heterocyclic compound as a RET kinase inhibitor
CA3133376A1 (en) * 2018-11-30 2020-06-04 Aptose Biosciences Inc. Combination therapy with 2,3-dihydro-isoindole-1-one compounds and methods for treating patients with various mutations
WO2022212893A1 (en) 2021-04-02 2022-10-06 Biogen Ma Inc. Combination treatment methods of multiple sclerosis

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Patent Citations (2)

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US20070161648A1 (en) * 2005-10-14 2007-07-12 Hughes Terry V Substituted dihydro-isoindolones useful in treating kinase disorders

Non-Patent Citations (1)

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Title
HUGHES, T. V. ET AL.: "7-[1H-Indol-2-yl]-2,3-dihydro-isoindol-1-ones as dual Aurora-A/ VEGF-R2 kinase inhibitors: Design, synthesis, and biological activity", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 18, 2008, pages 5130 - 5133, XP025407688, DOI: doi:10.1016/j.bmcl.2008.07.090 *

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