WO2011162678A1 - Method for performing maintenance on a chromatography column - Google Patents
Method for performing maintenance on a chromatography column Download PDFInfo
- Publication number
- WO2011162678A1 WO2011162678A1 PCT/SE2011/050746 SE2011050746W WO2011162678A1 WO 2011162678 A1 WO2011162678 A1 WO 2011162678A1 SE 2011050746 W SE2011050746 W SE 2011050746W WO 2011162678 A1 WO2011162678 A1 WO 2011162678A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- bottom plate
- adaptor
- chromatography column
- chromatography
- column
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/22—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/50—Conditioning of the sorbent material or stationary liquid
- G01N30/56—Packing methods or coating methods
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49718—Repairing
- Y10T29/49721—Repairing with disassembling
Definitions
- the present invention relates to a method for performing maintenance on a
- a chromatography column need to be cleaned or replaced regularly. For example access is needed beneath a bottom plate of the chromatography column to change a valve provided there. Usually there is not much space between the bottom plate and the floor because it is preferable to keep the overall height of the chromatography column as small as possible. Because of the limited space below the bottom plate it is tricky to get access to the bolts and valves that need to be accessed.
- An object of the present invention is to solve the problems described above related to prior art.
- Figures la-lc show schematically a chromatography system according to one
- Figure 2 shows schematically one example of a nut securing the bottom plate to the stand.
- Figure 3 is a flow chart of a method according to one embodiment of the invention that can be performed on the chromatography system of Figures la-lc.
- Figures 4a - 4d show schematically a chromatography system according to another embodiment of the invention in different positions of a method according to one embodiment of the invention.
- Figure 5 is a flow chart of a method according to one embodiment of the invention that can be performed on the chromatography system shown in the Figures 3a-3d.
- Figure 6 shows schematically a chromatography system according to another
- Figure la shows schematically a chromatography system according to one embodiment of the invention. All the parts are not mentioned here but they are conventional parts of a chromatography system.
- a chromatography column 1 is provided on a stand 3.
- a bottom plate 5 of the chromatography column is detachably secured with a detachable joint 7 to the stand 3.
- the detachable joint 7 is shown as two bolts 7 securing the bottom plate 5 to the stand 3.
- the chromatography column 1 comprises further a column tube 9, connected at its bottom end to a bottom flange 1 1 , a distributor 13 and the bottom plate 5.
- the column tube 9 is connected at its upper end to an upper flange 14.
- an adaptor 15 is provided in the chromatography system. According to the invention the adaptor 15 can be secured to the chromatography column 1 by a locking means 16.
- the adaptor 15 comprises an adaptor rod 17, a worm gear 19, an adaptor backing plate 21 and an adaptor stop 23.
- the adaptor stop 23 is provided in order to secure that the adaptor backing plate 21 will not be lifted above the column tube 9.
- a locking means 16 is provided to the upper flange 14 and is adapted to engage with the adaptor stop 23 when the adaptor 15 is raised such that the whole column can be raised from the stand when the detachable joint 7 has been released.
- the locking means 16 can instead be arranged to engage directly with the adaptor backing plate 21 when the adaptor 15 is raised when maintenance beneath the column is needed.
- the locking means 16 is detachable and will be removed when the adaptor needs to be lowered inside the column tube 9.
- the design of the locking means 16 can of course vary. Furthermore a lid 27 and a lid support 29 are provided above the column tube 9 and upper flange 14 and connected to the stand 3 in order to support the chromatography system structure and aid maintenance. This is according to conventional models of chromatography systems.
- FIG 1 c the chromatography system of Figure 1 a is shown schematically in a third position where the adaptor 15 is raised. Because of the locking means 16 securing the adaptor stop 23 and thus the adaptor backing plate 21 to the upper flange 14 of the chromatography column 1 and because the detachable joint 7 between the bottom plate 5 and the stand 3 has been released the chromatography column 1 will be raised above the stand 3 together with the adaptor 15. Hereby there will be a space below the bottom plate which can be used when access is needed to the underside of the chromatography column 1 for performing maintenance of the system. Furthermore a lock sprint 22 is possibly provided in order to secure the adaptor and the chromatography column in the raised position.
- FIG. 2 shows schematically in more detail the detachable joint 7 according to one embodiment of the invention.
- the bottom plate 5 and the stand 3 are shown partly in this view.
- the detachable joint 7 comprises a bolt 31, a lock nut 33 and a nut 35.
- the detachable joint 7 can of course be deigned differently.
- Figure 3 is a flow chart of a method according to one embodiment of the invention that can be performed on the system shown in Figures la-lc. The method steps are described in order below: SI : Lifting the lid 27 and lid support 29 to a first position.
- Figures 4a-4d show schematically a chromatography system according to another embodiment of the invention in different positions of a method according to one embodiment of the invention.
- the chromatography system comprises a chromatography column 41 on a stand 43 with a swing out feature, i.e. a column tube 45 together with an upper flange 47 and a bottom flange 49 can be separated from an upper lid 51 and a bottom plate 53 and then rotated out from these parts.
- the bottom plate 53 comprises here also a distributor 54.
- the column tube 45 is all time supported by the stand 43.
- Figure 5 is a flow chart of a method according to one embodiment of the invention that can be performed on the chromatography system shown in the Figures 4a-4d. The method steps are described in order below and with reference to the corresponding Figures 4a-4d.
- the adaptor 59 is locked to the bottom plate 53 by a locking means 61.
- the locking means 61 can be designed in different ways. In this shown embodiment one part of the locking means is attached to the adaptor by a bolt and another part of the locking means is attached to the bottom plate by another bolt.
- FIG. 6 shows schematically a chromatography system according to another embodiment of the invention. Most of the parts here are the same as the parts described in Figures la-lc and these parts will not be mentioned here. The difference in this embodiment is the design of the locking means 16'.
- an adaptor stop 23' is designed similar to the design of the adaptor stop 23 in Figures la-lc. The adaptor stop 23' is arranged to engage with a locking means 16' that is secured to the
- chromatography column 1 ' when the adaptor 15 ' is moving upwards when maintenance below the chromatography column is needed.
- the locking means 16' could be arranged to engage directly with the adapter in a construction without adapter stop.
- a detachable joint 7' For lifting the column with the adapter during maintenance a detachable joint 7' needs also to be detached as described in relation to Figures la-lc.
- the locking means 16' is a detachable part.
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201180030700.XA CN102946959B (en) | 2010-06-23 | 2011-06-16 | Method for performing maintenance on a chromatography column |
JP2013516525A JP5755736B2 (en) | 2010-06-23 | 2011-06-16 | How to maintain chromatography columns |
US13/703,388 US8668829B2 (en) | 2010-06-23 | 2011-06-16 | Method for performing maintenance on a chromatography column |
EP11798449.2A EP2585186B1 (en) | 2010-06-23 | 2011-06-16 | Method for performing maintenance on a chromatography column |
US14/159,046 US9155979B2 (en) | 2010-06-23 | 2014-01-20 | Method for performing maintenance on a chromatography column |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN1457/DEL/2010 | 2010-06-23 | ||
IN1457DE2010 | 2010-06-23 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/703,388 A-371-Of-International US8668829B2 (en) | 2010-06-23 | 2011-06-16 | Method for performing maintenance on a chromatography column |
US14/159,046 Division US9155979B2 (en) | 2010-06-23 | 2014-01-20 | Method for performing maintenance on a chromatography column |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2011162678A1 true WO2011162678A1 (en) | 2011-12-29 |
Family
ID=45371654
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/SE2011/050746 WO2011162678A1 (en) | 2010-06-23 | 2011-06-16 | Method for performing maintenance on a chromatography column |
Country Status (5)
Country | Link |
---|---|
US (2) | US8668829B2 (en) |
EP (1) | EP2585186B1 (en) |
JP (1) | JP5755736B2 (en) |
CN (1) | CN102946959B (en) |
WO (1) | WO2011162678A1 (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013191629A1 (en) * | 2012-06-21 | 2013-12-27 | Ge Healthcare Bio-Sciences Ab | Chromatography column stand |
WO2013191627A1 (en) | 2012-06-21 | 2013-12-27 | Ge Healthcare Bio-Sciences Ab | Chromatography column and method of conducting maintenance on a chromatography column |
JP2015034816A (en) * | 2013-08-07 | 2015-02-19 | ポール・コーポレーションPallCorporation | Chromatography column |
US20160152660A1 (en) * | 2013-07-09 | 2016-06-02 | Ge Healthcare Bio-Sciences Ab | An arrangement for a column, a method for substituting a tubular housing in such an arrangement for a column and a method for conducting peptide and/or oligonucleotide synthesis in a column |
CN104837536B (en) * | 2012-12-14 | 2018-01-02 | 通用电气医疗集团生物工艺研发股份公司 | The method for cleaning packed bed chromatographic column |
EP3556448A1 (en) * | 2018-04-16 | 2019-10-23 | Asahi Kasei Bioprocess, Inc. | Chromatography and synthesis column apparatus and method of assembly |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103505909B (en) | 2012-06-21 | 2018-02-13 | 通用电气健康护理生物科学股份公司 | Chromatographic column framework and the method safeguarded and filled to chromatographic column |
CN106413832B (en) * | 2014-04-12 | 2019-10-22 | 通用电气健康护理生物科学股份公司 | Promotion and holding system for chromatographic column |
Citations (5)
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US2007013A (en) | 1934-04-13 | 1935-07-02 | Monsanto Chemicals | Manufacture of salol |
US6736974B1 (en) * | 2001-11-02 | 2004-05-18 | Mann Welding Company | Chromatography column and method of operation |
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US20070138098A1 (en) * | 2003-12-10 | 2007-06-21 | Pall Euroflow Limited | Chromatography columns and their operation |
WO2009093952A1 (en) * | 2008-01-23 | 2009-07-30 | Ge Healthcare Bio-Sciences Ab | Chromatography column and maintenance method |
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JP2595015B2 (en) * | 1988-02-25 | 1997-03-26 | 東ソー株式会社 | Method for forming a packed bed of liquid chromatography column, and movable stopper type column apparatus used in the method |
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US20060124525A1 (en) * | 2004-09-07 | 2006-06-15 | Louis Bellafiore | Hoist-free chromatography column and method |
JP5048785B2 (en) * | 2006-12-13 | 2012-10-17 | バイオ−ラッド ラボラトリーズ,インコーポレイティド | Support structure for preparative chromatography columns |
US7708891B2 (en) * | 2007-06-15 | 2010-05-04 | Ge Healthcare Bio-Sciences Ab | Chromatography column and method of maintenance |
US7780853B2 (en) * | 2007-06-15 | 2010-08-24 | Ge Healthcare Bio-Sciences Ab | Method for conducting maintenance on a chromatography column |
US8066876B2 (en) * | 2009-11-23 | 2011-11-29 | Agilent Technologies, Inc. | Apparatus and methods for packing chromatography columns |
-
2011
- 2011-06-16 WO PCT/SE2011/050746 patent/WO2011162678A1/en active Application Filing
- 2011-06-16 US US13/703,388 patent/US8668829B2/en active Active
- 2011-06-16 JP JP2013516525A patent/JP5755736B2/en active Active
- 2011-06-16 EP EP11798449.2A patent/EP2585186B1/en active Active
- 2011-06-16 CN CN201180030700.XA patent/CN102946959B/en active Active
-
2014
- 2014-01-20 US US14/159,046 patent/US9155979B2/en active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
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US2007013A (en) | 1934-04-13 | 1935-07-02 | Monsanto Chemicals | Manufacture of salol |
US6736974B1 (en) * | 2001-11-02 | 2004-05-18 | Mann Welding Company | Chromatography column and method of operation |
US20070138098A1 (en) * | 2003-12-10 | 2007-06-21 | Pall Euroflow Limited | Chromatography columns and their operation |
US20060091052A1 (en) | 2004-11-02 | 2006-05-04 | Per Uselius | Chromatography column |
WO2009093952A1 (en) * | 2008-01-23 | 2009-07-30 | Ge Healthcare Bio-Sciences Ab | Chromatography column and maintenance method |
Non-Patent Citations (1)
Title |
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See also references of EP2585186A4 * |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9687756B2 (en) | 2012-06-21 | 2017-06-27 | Ge Healthcare Bio-Sciences Ab | Chromatography column stand |
WO2013191627A1 (en) | 2012-06-21 | 2013-12-27 | Ge Healthcare Bio-Sciences Ab | Chromatography column and method of conducting maintenance on a chromatography column |
CN104364645A (en) * | 2012-06-21 | 2015-02-18 | 通用电气健康护理生物科学股份公司 | Chromatography column and method of conducting maintenance on a chromatography column |
US10307692B2 (en) | 2012-06-21 | 2019-06-04 | Ge Healthcare Bio-Sciences Ab | Chromatography column and method of conducting maintenance on a chromatography column |
EP2864776A4 (en) * | 2012-06-21 | 2016-06-15 | Ge Healthcare Bio Sciences Ab | Chromatography column and method of conducting maintenance on a chromatography column |
WO2013191629A1 (en) * | 2012-06-21 | 2013-12-27 | Ge Healthcare Bio-Sciences Ab | Chromatography column stand |
CN104364645B (en) * | 2012-06-21 | 2016-10-19 | 通用电气健康护理生物科学股份公司 | Chromatographic column and the method that chromatographic column is safeguarded |
CN104837536B (en) * | 2012-12-14 | 2018-01-02 | 通用电气医疗集团生物工艺研发股份公司 | The method for cleaning packed bed chromatographic column |
JP2016530877A (en) * | 2013-07-09 | 2016-10-06 | ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ | Column configuration, method for exchanging tubular housing in such column configuration, and method for performing peptide and / or oligonucleotide synthesis in a column |
EP3019860A4 (en) * | 2013-07-09 | 2017-05-31 | GE Healthcare Bio-Sciences AB | An arrangement for a column, a method for substituting a tubular housing in such an arrangement for a column and a method for conducting peptide and/or oligonucleotide synthesis in a column |
US20160152660A1 (en) * | 2013-07-09 | 2016-06-02 | Ge Healthcare Bio-Sciences Ab | An arrangement for a column, a method for substituting a tubular housing in such an arrangement for a column and a method for conducting peptide and/or oligonucleotide synthesis in a column |
US10227377B2 (en) | 2013-07-09 | 2019-03-12 | Ge Healthcare Bio-Sciences Ab | Arrangement for a column, a method for substituting a tubular housing in such an arrangement for a column and a method for conducting peptide and/or oligonucleotide synthesis in a column |
JP2015034816A (en) * | 2013-08-07 | 2015-02-19 | ポール・コーポレーションPallCorporation | Chromatography column |
EP3556448A1 (en) * | 2018-04-16 | 2019-10-23 | Asahi Kasei Bioprocess, Inc. | Chromatography and synthesis column apparatus and method of assembly |
US11745119B2 (en) | 2018-04-16 | 2023-09-05 | Asahi Kasei Bioprocess America, Inc. | Chromatography and synthesis column apparatus and method of assembly |
Also Published As
Publication number | Publication date |
---|---|
JP5755736B2 (en) | 2015-07-29 |
US8668829B2 (en) | 2014-03-11 |
CN102946959B (en) | 2015-04-29 |
US20140131266A1 (en) | 2014-05-15 |
US20130087491A1 (en) | 2013-04-11 |
CN102946959A (en) | 2013-02-27 |
EP2585186A4 (en) | 2015-01-28 |
US9155979B2 (en) | 2015-10-13 |
EP2585186A1 (en) | 2013-05-01 |
EP2585186B1 (en) | 2017-01-18 |
JP2013529782A (en) | 2013-07-22 |
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