WO2010072184A2 - Liquid composition containing phosphoric or thiophosphoric triamide derivative and use thereof - Google Patents
Liquid composition containing phosphoric or thiophosphoric triamide derivative and use thereof Download PDFInfo
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- WO2010072184A2 WO2010072184A2 PCT/CZ2009/000161 CZ2009000161W WO2010072184A2 WO 2010072184 A2 WO2010072184 A2 WO 2010072184A2 CZ 2009000161 W CZ2009000161 W CZ 2009000161W WO 2010072184 A2 WO2010072184 A2 WO 2010072184A2
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- WO
- WIPO (PCT)
- Prior art keywords
- alkyl
- general formula
- group
- liquid composition
- esters
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 63
- 239000007788 liquid Substances 0.000 title claims abstract description 30
- JLYVRXJEQTZZBE-UHFFFAOYSA-N ctk1c6083 Chemical class NP(N)(N)=S JLYVRXJEQTZZBE-UHFFFAOYSA-N 0.000 title claims abstract description 21
- DMSZORWOGDLWGN-UHFFFAOYSA-N ctk1a3526 Chemical compound NP(N)(N)=O DMSZORWOGDLWGN-UHFFFAOYSA-N 0.000 title claims abstract description 20
- -1 heterocyclic alcohols Chemical class 0.000 claims abstract description 27
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims abstract description 20
- 239000004202 carbamide Substances 0.000 claims abstract description 20
- 239000003337 fertilizer Substances 0.000 claims abstract description 18
- 239000000126 substance Substances 0.000 claims abstract description 14
- 150000002148 esters Chemical class 0.000 claims abstract description 13
- 239000002601 urease inhibitor Substances 0.000 claims abstract description 9
- 241001465754 Metazoa Species 0.000 claims abstract description 8
- 210000002700 urine Anatomy 0.000 claims abstract description 6
- 230000000873 masking effect Effects 0.000 claims abstract description 5
- 239000007921 spray Substances 0.000 claims abstract description 5
- 229940090496 Urease inhibitor Drugs 0.000 claims abstract description 4
- 239000002699 waste material Substances 0.000 claims abstract description 4
- 150000001261 hydroxy acids Chemical class 0.000 claims abstract description 3
- HEPPIYNOUFWEPP-UHFFFAOYSA-N n-diaminophosphinothioylbutan-1-amine Chemical compound CCCCNP(N)(N)=S HEPPIYNOUFWEPP-UHFFFAOYSA-N 0.000 claims description 52
- 125000000217 alkyl group Chemical group 0.000 claims description 51
- LZCLXQDLBQLTDK-UHFFFAOYSA-N ethyl 2-hydroxypropanoate Chemical compound CCOC(=O)C(C)O LZCLXQDLBQLTDK-UHFFFAOYSA-N 0.000 claims description 20
- 125000003118 aryl group Chemical group 0.000 claims description 19
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 17
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 16
- 239000001257 hydrogen Substances 0.000 claims description 16
- 229910052739 hydrogen Inorganic materials 0.000 claims description 16
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 16
- 150000001875 compounds Chemical class 0.000 claims description 14
- 229910052757 nitrogen Inorganic materials 0.000 claims description 12
- 238000002425 crystallisation Methods 0.000 claims description 11
- 230000008025 crystallization Effects 0.000 claims description 11
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims description 10
- 125000004432 carbon atom Chemical group C* 0.000 claims description 10
- 229940116333 ethyl lactate Drugs 0.000 claims description 10
- 229910052760 oxygen Inorganic materials 0.000 claims description 10
- 239000001301 oxygen Substances 0.000 claims description 10
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 9
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 9
- 229910052736 halogen Inorganic materials 0.000 claims description 7
- 150000002367 halogens Chemical class 0.000 claims description 7
- 125000000623 heterocyclic group Chemical group 0.000 claims description 7
- 239000003112 inhibitor Substances 0.000 claims description 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 7
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 7
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 6
- 229910052717 sulfur Chemical group 0.000 claims description 6
- 125000004450 alkenylene group Chemical group 0.000 claims description 5
- GDPVISFVPDYFPN-UHFFFAOYSA-N n-[amino(hydroxy)phosphinimyl]-2-nitroaniline Chemical compound NP(N)(=O)NC1=CC=CC=C1[N+]([O-])=O GDPVISFVPDYFPN-UHFFFAOYSA-N 0.000 claims description 5
- WOPHQTWCQNDMGH-UHFFFAOYSA-N n-diaminophosphinothioylcyclohexanamine Chemical compound NP(N)(=S)NC1CCCCC1 WOPHQTWCQNDMGH-UHFFFAOYSA-N 0.000 claims description 5
- LPEKGGXMPWTOCB-UHFFFAOYSA-N 8beta-(2,3-epoxy-2-methylbutyryloxy)-14-acetoxytithifolin Natural products COC(=O)C(C)O LPEKGGXMPWTOCB-UHFFFAOYSA-N 0.000 claims description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 4
- 125000002252 acyl group Chemical group 0.000 claims description 4
- 125000002947 alkylene group Chemical group 0.000 claims description 4
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims description 4
- 125000004122 cyclic group Chemical group 0.000 claims description 4
- 150000001991 dicarboxylic acids Chemical class 0.000 claims description 4
- ODQWQRRAPPTVAG-GZTJUZNOSA-N doxepin Chemical compound C1OC2=CC=CC=C2C(=C/CCN(C)C)/C2=CC=CC=C21 ODQWQRRAPPTVAG-GZTJUZNOSA-N 0.000 claims description 4
- 230000002708 enhancing effect Effects 0.000 claims description 4
- ZANNOFHADGWOLI-UHFFFAOYSA-N ethyl 2-hydroxyacetate Chemical compound CCOC(=O)CO ZANNOFHADGWOLI-UHFFFAOYSA-N 0.000 claims description 4
- 125000005842 heteroatom Chemical group 0.000 claims description 4
- 125000001183 hydrocarbyl group Chemical group 0.000 claims description 4
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 4
- 229940057867 methyl lactate Drugs 0.000 claims description 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 4
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 4
- 125000004434 sulfur atom Chemical group 0.000 claims description 4
- 239000003086 colorant Substances 0.000 claims description 3
- 125000001424 substituent group Chemical group 0.000 claims description 3
- 239000004094 surface-active agent Substances 0.000 claims description 3
- IEPRKVQEAMIZSS-UHFFFAOYSA-N Di-Et ester-Fumaric acid Natural products CCOC(=O)C=CC(=O)OCC IEPRKVQEAMIZSS-UHFFFAOYSA-N 0.000 claims description 2
- IEPRKVQEAMIZSS-WAYWQWQTSA-N Diethyl maleate Chemical compound CCOC(=O)\C=C/C(=O)OCC IEPRKVQEAMIZSS-WAYWQWQTSA-N 0.000 claims description 2
- 239000005864 Sulphur Substances 0.000 claims description 2
- 150000001298 alcohols Chemical class 0.000 claims description 2
- HNEGQIOMVPPMNR-IHWYPQMZSA-N citraconic acid Chemical compound OC(=O)C(/C)=C\C(O)=O HNEGQIOMVPPMNR-IHWYPQMZSA-N 0.000 claims description 2
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims description 2
- UKFXDFUAPNAMPJ-UHFFFAOYSA-N ethylmalonic acid Chemical compound CCC(C(O)=O)C(O)=O UKFXDFUAPNAMPJ-UHFFFAOYSA-N 0.000 claims description 2
- ZIYVHBGGAOATLY-UHFFFAOYSA-N methylmalonic acid Chemical compound OC(=O)C(C)C(O)=O ZIYVHBGGAOATLY-UHFFFAOYSA-N 0.000 claims description 2
- 239000011593 sulfur Substances 0.000 claims description 2
- 239000002904 solvent Substances 0.000 abstract description 41
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 29
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
- 238000003860 storage Methods 0.000 description 8
- LZCLXQDLBQLTDK-BYPYZUCNSA-N ethyl (2S)-lactate Chemical compound CCOC(=O)[C@H](C)O LZCLXQDLBQLTDK-BYPYZUCNSA-N 0.000 description 7
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 6
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 239000007787 solid Substances 0.000 description 6
- 230000007774 longterm Effects 0.000 description 5
- 238000006460 hydrolysis reaction Methods 0.000 description 4
- 238000005470 impregnation Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- RUOJZAUFBMNUDX-UHFFFAOYSA-N propylene carbonate Chemical compound CC1COC(=O)O1 RUOJZAUFBMNUDX-UHFFFAOYSA-N 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- 229910021529 ammonia Inorganic materials 0.000 description 3
- 239000010828 animal waste Substances 0.000 description 3
- 239000001569 carbon dioxide Substances 0.000 description 3
- 229910002092 carbon dioxide Inorganic materials 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 230000007062 hydrolysis Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- BSYVTEYKTMYBMK-UHFFFAOYSA-N tetrahydrofurfuryl alcohol Chemical compound OCC1CCCO1 BSYVTEYKTMYBMK-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 150000001408 amides Chemical class 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- BEPAFCGSDWSTEL-UHFFFAOYSA-N dimethyl malonate Chemical compound COC(=O)CC(=O)OC BEPAFCGSDWSTEL-UHFFFAOYSA-N 0.000 description 2
- 150000002009 diols Chemical class 0.000 description 2
- 210000003608 fece Anatomy 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000010871 livestock manure Substances 0.000 description 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000002689 soil Substances 0.000 description 2
- 230000000087 stabilizing effect Effects 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 150000004072 triols Chemical class 0.000 description 2
- 125000005916 2-methylpentyl group Chemical group 0.000 description 1
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 1
- 239000005695 Ammonium acetate Substances 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- UIRBIJPMBUWYNJ-UHFFFAOYSA-N OC1C=[O]COC1 Chemical compound OC1C=[O]COC1 UIRBIJPMBUWYNJ-UHFFFAOYSA-N 0.000 description 1
- YSNVSVCWTBLLRW-UHFFFAOYSA-N OCC1CCOCC1 Chemical compound OCC1CCOCC1 YSNVSVCWTBLLRW-UHFFFAOYSA-N 0.000 description 1
- BOHGAOWOIJMTPZ-UHFFFAOYSA-N OCC1OCOC1 Chemical compound OCC1OCOC1 BOHGAOWOIJMTPZ-UHFFFAOYSA-N 0.000 description 1
- 108010046334 Urease Proteins 0.000 description 1
- 239000001089 [(2R)-oxolan-2-yl]methanol Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229940043376 ammonium acetate Drugs 0.000 description 1
- 235000019257 ammonium acetate Nutrition 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000003889 eye drop Substances 0.000 description 1
- 229940012356 eye drops Drugs 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 239000000576 food coloring agent Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229940074076 glycerol formal Drugs 0.000 description 1
- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 125000002883 imidazolyl group Chemical group 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 125000002757 morpholinyl group Chemical group 0.000 description 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 239000000618 nitrogen fertilizer Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000002971 oxazolyl group Chemical group 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 125000004193 piperazinyl group Chemical group 0.000 description 1
- 235000012731 ponceau 4R Nutrition 0.000 description 1
- 239000004175 ponceau 4R Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 125000003226 pyrazolyl group Chemical group 0.000 description 1
- 125000000168 pyrrolyl group Chemical group 0.000 description 1
- 238000004007 reversed phase HPLC Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 231100000378 teratogenic Toxicity 0.000 description 1
- 230000003390 teratogenic effect Effects 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- SWGJCIMEBVHMTA-UHFFFAOYSA-K trisodium;6-oxido-4-sulfo-5-[(4-sulfonatonaphthalen-1-yl)diazenyl]naphthalene-2-sulfonate Chemical compound [Na+].[Na+].[Na+].C1=CC=C2C(N=NC3=C4C(=CC(=CC4=CC=C3O)S([O-])(=O)=O)S([O-])(=O)=O)=CC=C(S([O-])(=O)=O)C2=C1 SWGJCIMEBVHMTA-UHFFFAOYSA-K 0.000 description 1
- 238000000825 ultraviolet detection Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/224—Phosphorus triamides
-
- C—CHEMISTRY; METALLURGY
- C05—FERTILISERS; MANUFACTURE THEREOF
- C05G—MIXTURES OF FERTILISERS COVERED INDIVIDUALLY BY DIFFERENT SUBCLASSES OF CLASS C05; MIXTURES OF ONE OR MORE FERTILISERS WITH MATERIALS NOT HAVING A SPECIFIC FERTILISING ACTIVITY, e.g. PESTICIDES, SOIL-CONDITIONERS, WETTING AGENTS; FERTILISERS CHARACTERISED BY THEIR FORM
- C05G3/00—Mixtures of one or more fertilisers with additives not having a specially fertilising activity
- C05G3/90—Mixtures of one or more fertilisers with additives not having a specially fertilising activity for affecting the nitrification of ammonium compounds or urea in the soil
Definitions
- the invention relates to a liquid composition containing urease inhibitors based on phosphoric or thiophosphoric triamide derivatives, containing novel solvents.
- Urea constitutes 46 % of the worldwide consumption of nitrogen in agriculture and is the most widely used nitrogen fertilizer. However, after its application to soil, its partial hydrolysis to yield ammonia and carbon dioxide occurs. This process is catalysed by the enzyme urease, which is produced by some bacteria and fungi. The gaseous products formed by the hydrolysis reaction (ammonia and carbon dioxide) volatilize to the atmosphere and thus, substantial losses from the total amount of the nitrogen applied to the field occur.
- urease inhibitors that are applied together with urea.
- urease inhibitors include the thiophosphoric triamide compounds disclosed in the US Pat. No. 4,530,714, above all N-(n-butyl)thiophosphoric triamide (NBPT).
- NBPT N-(n-butyl)thiophosphoric triamide
- the thiophosphoric triamides are used also for prevention of nitrogen loss from animal wastes (excrements, manure), which are caused by the enzymatic cleavage of urea present in the wastes to ammonia.
- urease inhibitors can be added to animal wastes also for the purpose of decreasing odour formation.
- the urease inhibitors may be utilized in sprays masking animal urine odour, which are used for dissuading animals from undesired territorial behaviour including territory marking by urine.
- Industrial grade N-(n-butyl)thiophosphoric triamide (NBPT) is a solid, waxy compound, which decomposes by the action of moisture and elevated temperature.
- NBPT solutions in a suitable solvent, which should comply with some basic requirements: high solubility and stability of NBPT in the solvent, resistance of the NBPT solutions against the crystallization at a low temperature, low viscosity of the concentrated solutions of NBPT, low toxicity, volatility and flammability, minimum content of water in the commercially available form of the solvent, low cost.
- NBPT N-(n-butyl)thiophosphoric triamide
- aliphatic diols and triols or their esters containing up to 50 wt. % of NBPT, preferably 20 - 30 wt. % of NBPT.
- These mixtures are suitable for the impregnation of granular urea, but they are liquid only at the temperatures above 15 0 C. Below this temperature, they solidify or crystallize. This undesired property renders the manipulation with the solutions and their application to granular urea in the course of its production, particularly during the cold periods of the year, when the temperature can fall deep below 0 °C.
- Object of the present invention is a liquid composition containing
- R 6 R 7 N(NH 2 ) 2 P Y (VIII) wherein Y is oxygen or sulphur atom and R 6 and R 7 are independently selected from the group comprising hydrogen, Ci-Ci 0 alkyl, C 3 -Ci O cycloalkyl, C 6 -Ci 0 aryl and di(hydrocarbyl)aminocarbonyl, in which the hydrocarbyls can be the same or different and are selected from the group comprising Ci-Ci 0 alkyl, C 3 -Ci 0 cycloalkyl, C 6 -Ci O aryl, or R 6 and R 7 together with the nitrogen atom, to which they are bound, may form a heterocyclic ring containing 1 to 5 carbon atoms and optionally further one or two heteroatoms selected from the group comprising nitrogen, sulphur and oxygen, whereas the alkyl, cycloalkyl, aryl and heterocyclic moieties may optionally be substituted with one to five groups selected from
- the alkyl groups may include, e.g., methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, pentyl, isopentyl, neopentyl, tert-pentyl, hexyl, 2-methylpentyl, heptyl, octyl, 2- ethylhexyl, isoctyl, nonyl, isononyl, decyl, isodecyl.
- Cycloalkyl groups may include, e.g., cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and cyclooktyl.
- Aryl groups may include, e.g., phenyl or naphthyl.
- R 6 R 7 N heterocyclic rings may be, e.g., piperazinyl, morpholinyl, pyrrolyl, pyrazolyl, triazolyl, oxazolyl, thiazolyl or imidazolyl,
- R 1 is hydrogen or methyl
- R 2 is Ci to C 6 primary alkyl, C 3 to C 6 secondary alkyl or C 4 to C 6 tertiary alkyl
- R 3 is hydrogen, Ci to C 4 primary alkyl, C 3 to C 4 secondary alkyl or C 1 to C 4 acyl and heterocyclic alcohols of formulas III, IV a V;
- R 4 is hydrogen, Ci to C 4 alkyl or Ci to C 2 hydroxyalkyl; and d) esters of dicarboxyacids of general formula VII
- composition may optionally further contain auxiliary substances improving the stability and application properties of the solutions.
- aryl is a group containing at least one aromatic cycle
- halogen is selected from the group comprising fluorine, chlorine, bromine, iodine
- nitro denotes the group -NO 2
- amino denotes the group -NH 2
- hydroxy denotes the group -OH
- methoxy denotes the group -OCH 3
- ethoxy denotes the group -OCH 2 CH 3 .
- Hydroxyacid esters of the general formula I may be in the form of optically active isomers, when R 1 is methyl. In a preferred embodiment, S-isomers of hydroxyacid esters are used. Preferred compounds of the general formula I are methyl lactate, ethyl lactate, methyl glycolate, and ethyl glycolate.
- the compounds of formulas II, III and VI may be used in the form of any optically active isomer or mixture of isomers.
- Esters of unsaturated dicarboxylic acids of formula VII may form E- and Z- isomers.
- Z-isomers of the esters of unsaturated dicarboxylic acids are used.
- Preferred compounds of general formula VII are methyl malonate, ethyl malonate, methyl maleate and ethyl maleate.
- the liquid composition comprises:
- R 6 R 7 N(NH 2 ) 2 P Y (VIII) wherein Y is oxygen or sulfur atom, and R 6 and R 7 are independently selected from the group comprising hydrogen, Ci-Ci 0 alkyl, C 3 -Ci 0 cycloalkyl, C 6 -Ci 0 aryl and di(hydrocarbyl)aminocarbonyl, in which the hydrocarbyls can be the same or different and are selected from the group comprising Ci-Ci 0 alkyl, C 3 -Ci 0 cycloalkyl, C 6 -Ci O aryl, or R 6 and R 7 together with the nitrogen atom, to which they are bound, may form a heterocyclic ring containing 1 to 5 carbon atoms and optionally further one or two heteroatoms selected from the group comprising nitrogen, sulfur and oxygen, whereas the alkyl, cycloalkyl and aryl substituents may optionally be substituted by one to five groups selected from the group comprising halogen,
- R is hydrogen, Ci to C 4 primary alkyl C 3 to C 4 secondary alkyl or Ci to C 4 acyl,
- X is Ci to C 6 alkylene or C 2 to C 6 alkenylene and R 5 is Ci to C 6 primary alkyl, C 3 to C 6 secondary alkyl or C 4 to C 6 tertiary alkyl; whereas the composition may optionally contain further auxiliary substances enhancing the stability and application properties of the solutions.
- the auxiliary substances enhancing the stability and application properties of solutions may be, e.g., crystallization inhibitors, surface active agents, or colorants.
- the crystallization inhibitors may be polyvinylpyrrolidone or N-methylpyrrolidone.
- the crystallization inhibitor used is polyvinylpyrrolidone in the concentration range of from 0.01 to 5 % w/w. This substance is non-toxic and is used in similar concentrations in, e.g., medicine as an additive to eye drops.
- a solid urea-containing fertilizer e.g., granulated urea
- colorants commonly used in agriculture or food industry may be added to the solution.
- surface active agents such as those commonly used in agriculture for this purpose may be added to the solution.
- the liquid composition according to the present invention can further contain at least one glycol ether of the general formula (IX)
- R is hydrogen or methyl
- the composition contains at least one phosphoric or thiophosphoric triamide derivative of general formula (Villa),
- the phosphoric or thiophosphoric triamide derivative of general formula Villa is selected from the group comprising N-(n- butyl) thiophosphoric acid triamide, N-cyclohexyl thiophosphoric acid triamide and N-(2-nitrophenyl) phosphoric acid triamide.
- the composition of the present invention contains 5 to 50 % w/w of the phosphoric or thiophosphoric triamide derivative of general formula VIII, preferably of N-(n-butyl) thiophosphoric triamide, N-cyclohexyl thiophosphoric triamide or N- (2-nitrophenyl) phosphoric triamide.
- the composition of the present invention contains 10 to 40 % w/w of the phosphoric or thiophosphoric triamide derivative of general formula VIII, preferably of N-(n-butyl) thiophosphoric triamide, N-cyclohexyl thiophosphoric triamide or N-(2-nitrophenyl) phosphoric triamide.
- the composition of the present invention contains 20 to 30 % w/w of the phosphoric or thiophosphoric triamide derivative of general formula VIII, preferably of N-(n-butyl) thiophosphoric triamide, N-cyclohexyl thiophosphoric triamide or N-(2-nitrophenyl) phosphoric triamide.
- Another object of the present invention is the use of the composition containing the phosphoric or thiophosphoric triamide derivative as urease inhibitor in urea- containing fertilizers.
- the urea-containing fertilizers may be solid, then the composition according to the present invention can be added to the mixture during the manufacture of these fertilizers, or the particles of the fertilizer, e.g., granules, can be impregnated by the composition of the present invention.
- the urea-containing fertilizers may be liquid, and then the composition of the present invention can be mixed with the liquid fertilizer.
- the composition can also be added to fertilizers and wastes of animal origin (excrements, manure) in order to decrease nitrogen loss and odour formation.
- the composition can also be added into sprays masking the animal urine odours.
- the solvents according to the present invention have properties that are advantageous for their use in agriculture: a high concentration of phosphoric or thiophosphoric triamide derivatives, such as N-(n-butyl) thiophosphoric acid triamide (NBPT), in the solution can be achieved and the derivatives (such as NBPT) are stabilized in these solutions.
- a high concentration of phosphoric or thiophosphoric triamide derivatives such as N-(n-butyl) thiophosphoric acid triamide (NBPT)
- NBPT N-(n-butyl) thiophosphoric acid triamide
- the solvents of the present invention are degradable to naturally occuring substances (e.g., lactic acid and ethanol for ethyl lactate, carbon dioxide and diols for carbon acid cyclic esters) and thus belong among ,,green" solvents.
- the importance of these solvents is gradually increasing, because their use does not add toxic residues into the environment.
- the solvents of the invention further show a high resistance against solidifying and crystallization at low temperatures, are water-miscible, they are not toxic and have a low volatility and flammability. Due to their solvent and chemical properties, the solvent systems of the invention are suitable for impregnation of granular urea and for addition into liquid fertilizers containing water as the solvent. Another advantage is their low cost.
- the invention is further illustrated by way of examples, which should not be construed as further limiting.
- N-(n-butyl) thiophosphoric triamide (NBPT) in the solvent systems of the present invention have the capability to remain liquid at very low temperatures. This capability is due to the chemical nature of the solvents. In this example, stability against crystallization and flowability of the compositions of the invention is described.
- the concentration of technical-grade NBPT in the solutions was 20 wt. %.
- the temperature -5 0 C was selected.
- the presence of crystals in the solutions yes-no
- the flowability of the solutions were assessed.
- the composition of the liquid compositions and the results are summarized in Table 1.
- Table 1 Effect of the composition of the solvent systems on the crystallization of NBPT from its solutions at the temperature of -5 0 C.
- composition D crystallization inhibitor polyvinylpyrrolidone
- Example 4 A high stability of N-(n-butyl)thiophosphoric triamide (NBPT) in the solvent system is the key feature for long-term storage of its solutions.
- the presence of water causes the decomposition of NBPT into non-effective substances during a longer storage and is the main cause of the NBPT degradation during a long-term storage.
- the solvent systems of the present invention show a stabilizing effect towards NBPT. All solvents used in this example are commercially available in a very good quality, having the water content lower than 0.1 wt. %. Nevertheless, to confirm the stabilization effect of the solvents, the water content was artificially increased to 1 wt. %. The thus adjusted solvent systems simulate the effect of the moisture on NBPT (higher contents of the moisture than 1 wt. % are uncommon).
- Table 3 Composition of solvents containing 1 wt. % water. Designation Composition of the solvent NR2 (S)-ethyl lactate containing 1 wt. % water
- NR4 propylene carbonate containing 1 wt. % water mixture containing 33 wt. % of ethyl lactate and 67 wt. % of propylene NR6 carbonate, further containing 1 wt. % water
- the solutions of NBPT in these solvents having the concentration ca 20 wt. % (weighed portion) were stored at room temperature at daylight in glass, well-sealed vials.
- the determination of the content of NBPT was carried out by reverse-phase HPLC with UV detection in the mobile phase containing 25 vol. % acetonitrile and 75 vol. % 0.005 M ammonium acetate.
- the chromatogram was evaluated at the wavelength of 193 nm.
- the mobile phase flow was 1 ml/min, the column temperature was 40 0 C.
- the injected volume was 5 ⁇ l.
- the evaluation was carried out by the method of external standard with the calibration using a calibration line. The results are summarized in Tab. 4.
- Table 4 Summary of the results (in wt. %) of the determination of NBPT content in time from the preparation of the composition.
- RSD is the relative deviation in rel. %, calculated from three repeats of sampling and two repeats of analysis of each sample.
- solutions of N-alkyl phosphoric or thiophosphoric triamides in the solvent systems of the present invention can be long-term stored, used for the impregnation of solid urea-containing fertilizers, such as granular urea, added into the mixture for the manufacture of solid urea-containing fertilizers or added into liquid urea- containing fertilizers. They can also be used as a suitable urease inhibitor formulation for addition into animal wastes or sprays masking urine odour.
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Abstract
The invention relates to a liquid composition containing phosphoric or thiophosphoric triamide derivatives and suitable solvents selected from the group comprising esters of hydroxyacids, heterocyclic alcohols and their derivatives, cyclic carbonic acid esters and dicarboxyacid esters, optionally the composition may also contain glycol ethers and auxiliary substances. The invention further includes the use of this liquid composition as urease inhibitor in urea-containing fertilizers, in fertilizers and wastes of animal origin or in sprays masking animal urine odours.
Description
Liquid composition containing phosphoric or thiophosphoric triamide derivative and use thereof
Field of Art
The invention relates to a liquid composition containing urease inhibitors based on phosphoric or thiophosphoric triamide derivatives, containing novel solvents.
Background Art
Urea constitutes 46 % of the worldwide consumption of nitrogen in agriculture and is the most widely used nitrogen fertilizer. However, after its application to soil, its partial hydrolysis to yield ammonia and carbon dioxide occurs. This process is catalysed by the enzyme urease, which is produced by some bacteria and fungi. The gaseous products formed by the hydrolysis reaction (ammonia and carbon dioxide) volatilize to the atmosphere and thus, substantial losses from the total amount of the nitrogen applied to the field occur.
The hydrolysis process can be considerably decelerated by urease inhibitors that are applied together with urea. Among the most effective urease inhibitors are the thiophosphoric triamide compounds disclosed in the US Pat. No. 4,530,714, above all N-(n-butyl)thiophosphoric triamide (NBPT). The use of NBPT was experimentally verified and this compound is now industrially available for the use in agriculture (Watson, CJ. (2005) Proc. Internat. Fertiliser Soc. 454, 1-38).
The thiophosphoric triamides are used also for prevention of nitrogen loss from animal wastes (excrements, manure), which are caused by the enzymatic cleavage of urea present in the wastes to ammonia. According to WO 98/27261, urease inhibitors can be added to animal wastes also for the purpose of decreasing odour formation. Similarly, the urease inhibitors may be utilized in sprays masking animal urine odour, which are used for dissuading animals from undesired territorial behaviour including territory marking by urine.
Industrial grade N-(n-butyl)thiophosphoric triamide (NBPT) is a solid, waxy compound, which decomposes by the action of moisture and elevated temperature. With regard to its consistence, its direct application onto urea particles is very difficult. Technologically more advantageous is the use of the NBPT solutions in a suitable solvent, which should comply with some basic requirements: high solubility and stability of NBPT in the solvent, resistance of the NBPT solutions against the crystallization at a low temperature, low viscosity of the concentrated solutions of NBPT, low toxicity, volatility and flammability, minimum content of water in the commercially available form of the solvent, low cost.
In the US Pat. No. 5,698,003, mixtures of N-(n-butyl)thiophosphoric triamide (NBPT) and aliphatic diols and triols or their esters are described, containing up to 50 wt. % of NBPT, preferably 20 - 30 wt. % of NBPT. These mixtures are suitable for the impregnation of granular urea, but they are liquid only at the temperatures above 15 0C. Below this temperature, they solidify or crystallize. This undesired property renders the manipulation with the solutions and their application to granular urea in the course of its production, particularly during the cold periods of the year, when the temperature can fall deep below 0 °C. US 5,698,003 teaches that the addition of so-called ,,liquid amides" (e.g. 10 wt. % of N-methylpyrrolidone) to these solvents can shift the solidification temperature to 0 0C. The liquid amides, however, are health-deleterious (N-methylpyrrolidone is often classified among carcinogenic and teratogenic compounds) and the solidifying temperature achieved is still not sufficient for the manipulation at low temperatures or at freezing.
Another issue is the technical quality and hygroscopicity of the commercially available diols and triols. They often contain few tenths of percent of water and this amount can further increase during storage due to the hygroscopicity of the solvents. During a longer storage period, the presence of water causes the decomposition of N- (n-butyl) thiophosphoric triamide (NBPT) into non-effective substances and is the main cause of the NBPT degradation during a long-term storage. The instability of NBPT towards hydrolysis is well known, e.g. because of it, NBPT is poorly utilizable on moist soils.
Czech patent application PV 2006-422 teaches a solvent system for the preparation of N-alkyl thiophosphoric triamide solutions containing glykolethers, and optionally further auxiliary substances, such as N-methylpyrrolidone or polyvinylpyrrolidone. The glycolethers show excellent solvent properties, but they belong among synthetic solvents. For both ecological and legislative reasons, it is at present more advantageous to use so-called ,,green" solvents, that decompose to natural substances in the ecosystem.
The above mentioned disadvantages can be solved by liquid compositions of N-alkyl phosphoric or thiophosphoric triamides with a new group of solvents according to the present invention.
Disclosure of the Invention
Object of the present invention is a liquid composition containing
- at least one phosphoric or thiophosphoric triamide derivative of general formula (VIII),
R6R7N(NH2)2P=Y (VIII) wherein Y is oxygen or sulphur atom and R6 and R7 are independently selected from the group comprising hydrogen, Ci-Ci0 alkyl, C3-CiO cycloalkyl, C6-Ci0 aryl and di(hydrocarbyl)aminocarbonyl, in which the hydrocarbyls can be the same or different and are selected from the group comprising Ci-Ci0 alkyl, C3-Ci0 cycloalkyl, C6-CiO aryl, or R6 and R7 together with the nitrogen atom, to which they are bound, may form a heterocyclic ring containing 1 to 5 carbon atoms and optionally further one or two heteroatoms selected from the group comprising nitrogen, sulphur and oxygen, whereas the alkyl, cycloalkyl, aryl and heterocyclic moieties may optionally be substituted with one to five groups selected from the group comprising halogen, nitro, amino, hydroxy, methoxy and ethoxy substituents. The alkyl groups may include, e.g., methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, pentyl, isopentyl, neopentyl, tert-pentyl, hexyl, 2-methylpentyl, heptyl, octyl, 2- ethylhexyl, isoctyl, nonyl, isononyl, decyl, isodecyl. Cycloalkyl groups may include, e.g., cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and cyclooktyl. Aryl groups may include, e.g., phenyl or naphthyl. R6R7N heterocyclic rings may be, e.g.,
piperazinyl, morpholinyl, pyrrolyl, pyrazolyl, triazolyl, oxazolyl, thiazolyl or imidazolyl,
- and one or more compounds selected from the group comprising a) esters of hydroxyacids of general formula I,
b) heterocyklic alcohols and derivatives thereof of general formula II,
(III) (IV) (V)
c) cyclic esters of carbonic acid of general formula VI,
wherein X is Ci to C6 alkylene or C2 to C6 alkenylene and R5 is Ci to C6 primary alkyl, C3 to C6 secondary alkyl or C4 to C6 tertiary alkyl, whereas the composition may optionally further contain auxiliary substances improving the stability and application properties of the solutions.
Herein, the substituent names have the following meanings: aryl is a group containing at least one aromatic cycle, halogen is selected from the group comprising fluorine, chlorine, bromine, iodine, nitro denotes the group -NO2, amino denotes the group -NH2, hydroxy denotes the group -OH, methoxy denotes the group -OCH3 and ethoxy denotes the group -OCH2CH3.
Hydroxyacid esters of the general formula I may be in the form of optically active isomers, when R1 is methyl. In a preferred embodiment, S-isomers of hydroxyacid esters are used. Preferred compounds of the general formula I are methyl lactate, ethyl lactate, methyl glycolate, and ethyl glycolate.
The compounds of formulas II, III and VI may be used in the form of any optically active isomer or mixture of isomers.
Esters of unsaturated dicarboxylic acids of formula VII may form E- and Z- isomers.
In a preferred embodiment, Z-isomers of the esters of unsaturated dicarboxylic acids are used. Preferred compounds of general formula VII are methyl malonate, ethyl malonate, methyl maleate and ethyl maleate.
In a preferred embodiment, the liquid composition comprises:
- at least one phosphoric or thiophosphoric triamide derivative of general formula
(VIII),
R6R7N(NH2)2P=Y (VIII)
wherein Y is oxygen or sulfur atom, and R6 and R7 are independently selected from the group comprising hydrogen, Ci-Ci0 alkyl, C3-Ci0 cycloalkyl, C6-Ci0 aryl and di(hydrocarbyl)aminocarbonyl, in which the hydrocarbyls can be the same or different and are selected from the group comprising Ci-Ci0 alkyl, C3-Ci0 cycloalkyl, C6-CiO aryl, or R6 and R7 together with the nitrogen atom, to which they are bound, may form a heterocyclic ring containing 1 to 5 carbon atoms and optionally further one or two heteroatoms selected from the group comprising nitrogen, sulfur and oxygen, whereas the alkyl, cycloalkyl and aryl substituents may optionally be substituted by one to five groups selected from the group comprising halogen, nitro, amino, hydroxy, methoxy and ethoxy substituents;
- at least one compound of general formula I selected from the group comprising methyl lactate, ethyl lactate, methyl glycolate, ethyl glycolate, preferably, the compound of general formula I is ethyl lactate,
- and optionally one or more compounds selected from the group comprising b) heterocyclic alcohols and derivatives thereof of general formula II,
and heterocyclic alcohols of formulas III, IV and V,
c) cyclic esters of carbonic acid of general formula VI,
wherein R4 is hydrogen, Ci to C4 alkyl or Ci to C2 hydroxyalkyl and d) esters of dicarboxyacids of general formula VII
wherein X is Ci to C6 alkylene or C2 to C6 alkenylene and R5 is Ci to C6 primary alkyl, C3 to C6 secondary alkyl or C4 to C6 tertiary alkyl; whereas the composition may optionally contain further auxiliary substances enhancing the stability and application properties of the solutions.
The auxiliary substances enhancing the stability and application properties of solutions may be, e.g., crystallization inhibitors, surface active agents, or colorants. In a preferred embodiment, the crystallization inhibitors may be polyvinylpyrrolidone or N-methylpyrrolidone. Preferably, the crystallization inhibitor used is polyvinylpyrrolidone in the concentration range of from 0.01 to 5 % w/w. This substance is non-toxic and is used in similar concentrations in, e.g., medicine as an additive to eye drops. For indication of homogeneity of the coverage of a solid urea-containing fertilizer (e.g., granulated urea) surface by the solution of the phosphoric or thiophosphoric triamide derivative, colorants commonly used in agriculture or food industry may be added to the solution. In order to achieve a sufficient coverage of a solid urea-containing fertilizer (e.g., granulated urea) surface by the solution of the phosphoric or thiophosphoric triamide derivative, surface active agents such as those commonly used in agriculture for this purpose may be added to the solution.
The liquid composition according to the present invention can further contain at least one glycol ether of the general formula (IX)
8 O wherein R is hydrogen or methyl, R is a substituent selected from the group comprising C1-C6 primary alkyl, C3-C6 isoalkyl, C4-C6 tertiary alkyl, m = 2-4.
In a preferred embodiment, the composition contains at least one phosphoric or thiophosphoric triamide derivative of general formula (Villa),
R6aNH(NH2)2P=Y (Villa) wherein Y is oxygen or sulfur atom and R6a is selected from the group comprising linear or branched alkyl chains having 1 to 8 carbon atoms, cycloalkyl chains having 3 to 8 carbon atoms and aryl groups containing 6 to 10 carbon atoms, whereas these alkyl, cycloalkyl and aryl substituents may optionally be substituted by one to five groups selected from the group comprising halogen, nitro, amino, hydroxy, methoxy and ethoxy substituents. Preferably, the phosphoric or thiophosphoric triamide derivative of general formula Villa is selected from the group comprising N-(n- butyl) thiophosphoric acid triamide, N-cyclohexyl thiophosphoric acid triamide and N-(2-nitrophenyl) phosphoric acid triamide.
Preferably, the composition of the present invention contains 5 to 50 % w/w of the phosphoric or thiophosphoric triamide derivative of general formula VIII, preferably of N-(n-butyl) thiophosphoric triamide, N-cyclohexyl thiophosphoric triamide or N- (2-nitrophenyl) phosphoric triamide.
More preferably, the composition of the present invention contains 10 to 40 % w/w of the phosphoric or thiophosphoric triamide derivative of general formula VIII, preferably of N-(n-butyl) thiophosphoric triamide, N-cyclohexyl thiophosphoric triamide or N-(2-nitrophenyl) phosphoric triamide.
Most preferably, the composition of the present invention contains 20 to 30 % w/w of the phosphoric or thiophosphoric triamide derivative of general formula VIII,
preferably of N-(n-butyl) thiophosphoric triamide, N-cyclohexyl thiophosphoric triamide or N-(2-nitrophenyl) phosphoric triamide.
Another object of the present invention is the use of the composition containing the phosphoric or thiophosphoric triamide derivative as urease inhibitor in urea- containing fertilizers. The urea-containing fertilizers may be solid, then the composition according to the present invention can be added to the mixture during the manufacture of these fertilizers, or the particles of the fertilizer, e.g., granules, can be impregnated by the composition of the present invention. In another embodiment of the present invention, the urea-containing fertilizers may be liquid, and then the composition of the present invention can be mixed with the liquid fertilizer. The composition can also be added to fertilizers and wastes of animal origin (excrements, manure) in order to decrease nitrogen loss and odour formation. The composition can also be added into sprays masking the animal urine odours.
The solvents according to the present invention have properties that are advantageous for their use in agriculture: a high concentration of phosphoric or thiophosphoric triamide derivatives, such as N-(n-butyl) thiophosphoric acid triamide (NBPT), in the solution can be achieved and the derivatives (such as NBPT) are stabilized in these solutions.
The solvents of the present invention are degradable to naturally occuring substances (e.g., lactic acid and ethanol for ethyl lactate, carbon dioxide and diols for carbon acid cyclic esters) and thus belong among ,,green" solvents. The importance of these solvents is gradually increasing, because their use does not add toxic residues into the environment. The solvents of the invention further show a high resistance against solidifying and crystallization at low temperatures, are water-miscible, they are not toxic and have a low volatility and flammability. Due to their solvent and chemical properties, the solvent systems of the invention are suitable for impregnation of granular urea and for addition into liquid fertilizers containing water as the solvent. Another advantage is their low cost.
The invention is further illustrated by way of examples, which should not be construed as further limiting.
Examples
Example 1
Preparation of solution of N-(n-butyl)thiophosphoric triamide in (S)-ethyl lactate:
2.0 kg of N-(n-butyl)thiophosphoric triamide was slowly added to 8.0 kg of (S)-ethyl lactate under stirring. A clear solution was formed.
Example 2
Preparation of solution of N-(n-butyl)thiophosphoric triamide in the mixture of (S)- ethyl lactate and dimethyl malonate:
2.0 kg of N-(n-butyl)thiophosphoric triamide was slowly added to the mixture of 3.0 kg of (S)-ethyl lactate and 5.0 kg of dimethyl malonate under stirring. A clear solution was formed.
Example 3
The solutions of N-(n-butyl) thiophosphoric triamide (NBPT) in the solvent systems of the present invention have the capability to remain liquid at very low temperatures. This capability is due to the chemical nature of the solvents. In this example, stability against crystallization and flowability of the compositions of the invention is described.
The concentration of technical-grade NBPT in the solutions was 20 wt. %. For testing, the temperature -5 0C was selected. After 1 month of storage the presence of crystals in the solutions (yes-no) and the flowability of the solutions were assessed. The composition of the liquid compositions and the results are summarized in Table 1.
Abbreviations used:
(S)-ethyl lactate EL propylene carbonate PC
tetrahydrofurfuryl alcohol THFA polyvinylpyrrolidone PVP
N-methyl pyrrolidone NMP glycerol formal GF propylene glycol PG
Table 1 : Effect of the composition of the solvent systems on the crystallization of NBPT from its solutions at the temperature of -5 0C.
Composition _ on Composition components (wt. %) at — 3 L,
NBPT EL PC THFA PVP GF NMP PG
A no 2 200 4 400 40
B no 2200 1100 70
C no 2200 4400 10 30
D no 2200 3399 40
E no 2200 5500 30
F no 2200 4400 40
G no 2200 3300 50
H yes 2200 10 70
All prepared solutions showed an excellent flowability. The solvent systems have proven very technologically suitable for the preparation of NBPT solutions, because highly concentrated compositions containing 20 wt. % of NBPT do not crystallize at a low temperature and maintain an excellent flowability also after cooling. Binary (A, B, E, F and G) and ternary (C) solvent systems have similar properties. The addition of crystallization inhibitor polyvinylpyrrolidone (composition D) does not adversely affect the flowability of the solution. All solvent systems are water- miscible. For comparison with the prior art, a mixture containing propylene glycol (PG) with 10 wt. % N-methyl pyrrolidone (NMP) described in the US 5,698,003 was used. This mixture crystallized under said conditions.
Example 4 A high stability of N-(n-butyl)thiophosphoric triamide (NBPT) in the solvent system is the key feature for long-term storage of its solutions. The presence of water causes
the decomposition of NBPT into non-effective substances during a longer storage and is the main cause of the NBPT degradation during a long-term storage.
The solvent systems of the present invention show a stabilizing effect towards NBPT. All solvents used in this example are commercially available in a very good quality, having the water content lower than 0.1 wt. %. Nevertheless, to confirm the stabilization effect of the solvents, the water content was artificially increased to 1 wt. %. The thus adjusted solvent systems simulate the effect of the moisture on NBPT (higher contents of the moisture than 1 wt. % are uncommon).
In order to verify the long-term stability of NBPT, the following solvents containing less than 0.1 wt. % of water were selected, which are characterized in Table 2.
Table 2: Composition of solvents
Designation Composition of the solvent
NRl (S)-ethyl lactate
NR3 propylene carbonate
NR5 mixture containing 33 wt. % of ethyl lactate and 67 wt. % of propylene carbonate
These solvents were further adjusted to 1 wt. % water content, whereby the solvents characterized in Table 3 were obtained.
Table 3: Composition of solvents containing 1 wt. % water. Designation Composition of the solvent NR2 (S)-ethyl lactate containing 1 wt. % water
NR4 propylene carbonate containing 1 wt. % water mixture containing 33 wt. % of ethyl lactate and 67 wt. % of propylene NR6 carbonate, further containing 1 wt. % water
The solutions of NBPT in these solvents having the concentration ca 20 wt. % (weighed portion) were stored at room temperature at daylight in glass, well-sealed vials.
The determination of the content of NBPT was carried out by reverse-phase HPLC with UV detection in the mobile phase containing 25 vol. % acetonitrile and 75 vol. % 0.005 M ammonium acetate. The chromatogram was evaluated at the wavelength of 193 nm. The mobile phase flow was 1 ml/min, the column temperature was 40 0C. The injected volume was 5 μl. The evaluation was carried out by the method of external standard with the calibration using a calibration line. The results are summarized in Tab. 4.
Table 4: Summary of the results (in wt. %) of the determination of NBPT content in time from the preparation of the composition. RSD is the relative deviation in rel. %, calculated from three repeats of sampling and two repeats of analysis of each sample.
NBPT content (wt . %)
0 days 14 days 39 days 3 months
Designation RSD RSD RSD RSD
(%) (%) (%) (%)
NRl 19.62 1.74 19.66 1.40 19.51 0.84 19.46 1.35
NR2 20.08 1.63 19.90 1.39 19.45 2.16 19.59 0.84
NR3 19.62 0.90 19.46 2.05 19.45 1.53 19.61 1.00
NR4 19.82 1.18 19.50 1.20 19.41 1.33 19.51 1.10
NR5 19.83 1.22 19.78 0.87 19.54 1.16 19.51 0.86
NR6 20.00 1.91 19.67 0.67 19.32 0.97 19.30 0.32
The results show that the solvent systems of the present invention have a stabilizing effect towards NBPT, even at the water content of 1 wt. %. After twelve weeks of storage, no significant decrease of the content of the active component NBPT occurred in any sample (the method used can determine the change of approx. at least 1 wt. %).
Example 5
Preparation of granulated urea containing N-(n-butyl)thiophosphoric triamide
1 ton of granulated urea was impregnated in an impregnation machine by 3 kg of the composition of example 1 containing 20 wt. % NBPT, into which food colorants
were added (Brilliant Blue FCF, 0.033% and Ponceau 4R, 0.033%) in order to assess the homogeneity of the coverage of the granule surface. It was observed that the composition was homogeneously distributed on the granule surface.
Industrial Applicability
The solutions of N-alkyl phosphoric or thiophosphoric triamides in the solvent systems of the present invention can be long-term stored, used for the impregnation of solid urea-containing fertilizers, such as granular urea, added into the mixture for the manufacture of solid urea-containing fertilizers or added into liquid urea- containing fertilizers. They can also be used as a suitable urease inhibitor formulation for addition into animal wastes or sprays masking urine odour.
Claims
1. A liquid composition, characterized in that it contains: - at least one phosphoric or thiophosphoric triamide derivative of general formula (VIII),
R6R7N(NH2)2P=Y (VIII) wherein Y is oxygen or sulphur atom and R6 and R7 are independently selected from the group comprising hydrogen, C1-Ci0 alkyl, C3-Ci0 cycloalkyl, C6-CiO aryl and di(hydrocarbyl)aminocarbonyl, in which the hydrocarbyls can be the same or different and are selected from the group comprising Ci-Ci0 alkyl, C3-CiO cycloalkyl, C6-Ci0 aryl, or R6 and R7 together with the nitrogen atom, to which they are bound, may form a heterocyclic ring containing 1 to 5 carbon atoms and optionally further one or two heteroatoms selected from the group comprising nitrogen, sulphur and oxygen, whereas the alkyl, cycloalkyl, aryl and heterocyclic moieties may optionally be substituted with one to five groups selected from the group comprising halogen, nitro, amino, hydroxy, methoxy and ethoxy substituents;
- and one or more compounds selected from the group comprising a) esters of hydroxyacids of general formula I,
b) heterocyklic alcohols and derivatives thereof of general formula II,
(III) (IV) (V)
c) cyclic esters of carbonic acid of general formula VI,
wherein X is Ci to C6 alkylene or C2 to C6 alkenylene and R is Ci to C6 primary alkyl, C3 to C6 secondary alkyl or C4 to C6 tertiary alkyl, whereas the composition may optionally further contain auxiliary substances improving the stability and application properties of the solutions.
2. The liquid composition of claim 1, characterized in that the hydroxyacid esters of the general formula I, wherein R1 is methyl, are in the form of S-isomers.
3. The liquid composition of claim 1, characterized in that the hydroxyacid esters of the general formula I are selected from the group comprising methyl lactate, ethyl lactate, methyl glycolate, and ethyl glycolate, preferably the hydroxyacid ester of the general formula I is ethyl lactate.
4. The liquid composition of claim 1, characterized in that the esters of dicarboxylic acids of the general formula VII, wherein X is C2 to C6 alkenylene, are in the form of Z-isomers.
5. The liquid composition of claim 1, characterized in that the esters of dicarboxylic acids of the general formula VII are selected from the group comprising methyl malonate, ethyl malonate, methyl maleate and ethyl maleate.
6. The liquid composition according to claim 1, characterized in that it comprises:
- at least one phosphoric or thiophosphoric triamide derivative of general formula (VIII),
R6R7N(NH2)2P=Y (VIII) wherein Y is oxygen or sulfur atom, and R6 and R7 are independently selected from the group comprising hydrogen, Ci-Ci0 alkyl, C3-CiO cycloalkyl, C6-Ci0 aryl and di(hydrocarbyl)aminocarbonyl, in which the hydrocarbyls can be the same or different and are selected from the group comprising Ci-Ci0 alkyl, C3-C]0 cycloalkyl, C6-Ci0 aryl, or R6 and R7 together with the nitrogen atom, to which they are bound, may form a heterocyclic ring containing 1 to 5 carbon atoms and optionally further one or two heteroatoms selected from the group comprising nitrogen, sulfur and oxygen, whereas the alkyl, cycloalkyl and aryl substituents may optionally be substituted by one to five groups selected from the group comprising halogen, nitro, amino, hydroxy, methoxy and ethoxy substituents;
- at least one compound of general formula I selected from the group comprising methyl lactate, ethyl lactate, methyl glycolate, ethyl glycolate, preferably, the compound of general formula I is ethyl lactate,
- and optionally one or more compounds selected from the group comprising b) heterocyclic alcohols and derivatives thereof of general formula II,
and heterocyclic alcohols of formulas III, IV and V,
(III) (IV) (V)
c) cyclic esters of carbonic acid of general formula VI,
wherein X is Ci to C6 alkylene or C2 to C6 alkenylene and R5 is Ci to C6 primary alkyl, C3 to C6 secondary alkyl or C4 to C6 tertiary alkyl; whereas the composition may optionally contain further auxiliary substances enhancing the stability and application properties of the solutions.
7. The liquid composition according to any of claims 1 to 6, characterized in that the auxiliary substances enhancing the stability and application properties of the solutions are selected from the group comprising crystallization inhibitors, surface active agents, and colorants.
8. The liquid composition according to claim 7, characterized in that the crystallization inhibitors are polyvinylpyrrolidone or N-methylpyrrolidone, preferably, the crystallization inhibitor is polyvinylpyrrolidone in the concentration range of from 0.01 to 5 % w/w.
9. The liquid composition according to any of claims 1 to 8, characterized in that it further contains at least one glycol ether of the general formula (IX)
wherein R8 is hydrogen or methyl, R9 is a substituent selected from the group comprising Ci-C6 primary alkyl, C3-C6 isoalkyl, C4-C6 tertiary alkyl, m = 2-4.
10. The liquid composition according to any of claims 1 to 9, characterized in that the phosphoric or thiophosphoric triamide derivative is a derivative of general formula (Villa),
R6aNH(NH2)2P=Y (Villa) wherein Y is oxygen or sulfur atom and R6a is selected from the group comprising linear or branched alkyl chains having 1 to 8 carbon atoms, cycloalkyl chains having 3 to 8 carbon atoms and aryl groups containing 6 to 10 carbon atoms, whereas these alkyl, cycloalkyl and aryl substituents may optionally be substituted by one to five groups selected from the group comprising halogen, nitro, amino, hydroxy, methoxy and ethoxy substituents; preferably, the phosphoric or thiophosphoric triamide derivative of general formula Villa is selected from the group comprising N-(n- butyl) thiophosphoric acid triamide, N-cyclohexyl thiophosphoric acid triamide and N-(2-nitrophenyl) phosphoric acid triamide.
11. The liquid composition according to claim 1 , characterized in that it contains 5 to 50 % wt/wt, preferably 10 to 40 % wt/wt, more preferably 20 to 30 % wt/wt of the phosphoric or thiophosphoric triamide derivative of general formula VIII.
12. Use of the liquid composition according to any of claims 1 to 11 as urease inhibitor in urea-containing fertilizers, in fertilizers and wastes of animal origin or in sprays masking animal urine odours.
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/132,565 US8617425B2 (en) | 2008-12-23 | 2009-12-21 | Liquid composition containing phosphoric or thiophosphoric triamide derivative and use thereof |
| ES09815452.9T ES2461146T3 (en) | 2008-12-23 | 2009-12-21 | Liquid composition containing phosphoric or thiophosphoric triamide derivative and use thereof |
| PL09815452T PL2376506T3 (en) | 2008-12-23 | 2009-12-21 | Liquid composition containing phosphoric or thiophosphoric triamide derivative and use thereof |
| AU2009329568A AU2009329568A1 (en) | 2008-12-23 | 2009-12-21 | Liquid composition containing phosphoric or thiophosphoric triamide derivative and use thereof |
| EA201100886A EA020890B1 (en) | 2008-12-23 | 2009-12-21 | Liquid composition containing phosphoric or thiophosphoric triamide derivative and use thereof |
| DK09815452.9T DK2376506T3 (en) | 2008-12-23 | 2009-12-21 | Liquid composition containing phosphoric acid or thiophosphoric triamide derivative and use thereof |
| CA2745584A CA2745584C (en) | 2008-12-23 | 2009-12-21 | Liquid composition containing phosphoric or thiophosphoric triamide derivative and use thereof |
| EP09815452.9A EP2376506B1 (en) | 2008-12-23 | 2009-12-21 | Liquid composition containing phosphoric or thiophosphoric triamide derivative and use thereof |
| NZ593120A NZ593120A (en) | 2008-12-23 | 2009-12-21 | Liquid composition containing phosphoric or thiophosphoric triamide derivative and use thereof |
| CN200980152228XA CN102264748A (en) | 2008-12-23 | 2009-12-21 | Liquid composition containing phosphoric or thiophosphoric triamide derivative and use thereof |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CZPV2008-842 | 2008-12-23 | ||
| CZ20080842A CZ2008842A3 (en) | 2008-12-23 | 2008-12-23 | Liquid composition ontaining derivative of phosphoric or thiophosphoric acid thiamide and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2010072184A2 true WO2010072184A2 (en) | 2010-07-01 |
| WO2010072184A3 WO2010072184A3 (en) | 2010-08-19 |
Family
ID=42154275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/CZ2009/000161 WO2010072184A2 (en) | 2008-12-23 | 2009-12-21 | Liquid composition containing phosphoric or thiophosphoric triamide derivative and use thereof |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8617425B2 (en) |
| EP (1) | EP2376506B1 (en) |
| CN (1) | CN102264748A (en) |
| AU (1) | AU2009329568A1 (en) |
| CA (1) | CA2745584C (en) |
| CZ (1) | CZ2008842A3 (en) |
| DK (1) | DK2376506T3 (en) |
| EA (1) | EA020890B1 (en) |
| ES (1) | ES2461146T3 (en) |
| NZ (1) | NZ593120A (en) |
| PL (1) | PL2376506T3 (en) |
| PT (1) | PT2376506E (en) |
| WO (1) | WO2010072184A2 (en) |
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| WO2014100561A1 (en) * | 2012-12-20 | 2014-06-26 | Rhodia Operations | Liquid dicyandiamide and/or alkyl thiophosphoric triamide compositions and their use in agricultural applications |
| DE102013012760A1 (en) | 2013-03-27 | 2014-10-02 | Dreiturm GmbH | Compositions containing a dispersed urease inhibitor, and their use for the treatment of urea-based fertilizers |
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| US9212101B2 (en) | 2012-08-15 | 2015-12-15 | Koch Agronomic Services, Llc | Liquid compositions containing urease inhibitors and aryl alkyl alcohols and methods of making and use thereof |
| WO2016137815A1 (en) | 2015-02-24 | 2016-09-01 | Koch Agronomic Services, Llc | Granular Urea Fertilizer with Nitrogen Stabilizer Additives |
| WO2016174648A1 (en) * | 2015-04-30 | 2016-11-03 | Universidade Federal De Minas Gerais - Ufmg | Urea pearls combined with aldimines, method for producing same and uses thereof in agriculture, and uses of aldimines for the treatment of bacterial infections |
| WO2017011397A1 (en) * | 2015-07-13 | 2017-01-19 | Koch Agronomic Services, Llc | Highly concentrated phosphoric or thiophosphoric triamide formulation |
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| DE102019201159A1 (en) | 2019-01-30 | 2020-07-30 | Skw Stickstoffwerke Piesteritz Gmbh | Highly effective concentrates with PPDA and their use to stabilize the valuable substances in animal excrement |
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Also Published As
| Publication number | Publication date |
|---|---|
| US8617425B2 (en) | 2013-12-31 |
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