WO2010067300A1 - Automatic road mapping for heart valve replacement - Google Patents
Automatic road mapping for heart valve replacement Download PDFInfo
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- WO2010067300A1 WO2010067300A1 PCT/IB2009/055547 IB2009055547W WO2010067300A1 WO 2010067300 A1 WO2010067300 A1 WO 2010067300A1 IB 2009055547 W IB2009055547 W IB 2009055547W WO 2010067300 A1 WO2010067300 A1 WO 2010067300A1
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- 210000003709 heart valve Anatomy 0.000 title claims abstract description 34
- 238000013507 mapping Methods 0.000 title abstract description 14
- 238000000034 method Methods 0.000 claims abstract description 40
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- 238000002594 fluoroscopy Methods 0.000 claims abstract description 25
- 239000002872 contrast media Substances 0.000 claims abstract description 19
- 238000004364 calculation method Methods 0.000 claims abstract description 12
- 210000002216 heart Anatomy 0.000 claims abstract description 9
- 238000004590 computer program Methods 0.000 claims description 9
- 238000003384 imaging method Methods 0.000 claims description 9
- 238000012545 processing Methods 0.000 claims description 6
- 238000002513 implantation Methods 0.000 abstract description 7
- 210000000709 aorta Anatomy 0.000 description 30
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- 238000010586 diagram Methods 0.000 description 3
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- 210000002837 heart atrium Anatomy 0.000 description 1
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- 238000002347 injection Methods 0.000 description 1
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Classifications
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- A61B6/504—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for diagnosis of blood vessels, e.g. by angiography
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Definitions
- the present invention is related to a method for automatic road mapping for heart valve replacement and an examination apparatus for automatic road mapping for heart valve replacement amongst others.
- Heart valve problems or heart valve diseases are becoming more important because of an ageing population.
- Such diseases for example aortic stenoses, usually require the replacement of a native heart valve, for example of the aortic valve, which is the most important and thus most critical valve of the human heart.
- the valve replacement can be done in two different ways, for example.
- the surgical valve replacement is considered as a "gold standard" treatment.
- the so- called percutaneous valve replacement is a fairly new intervention that is increasingly applied.
- Percutaneous valve replacement usually includes transcatheter heart valve implantation. With this method the valve can be placed either through the femoral vessels, vein or arteria (transfemoral) or through the apex of the left ventricle (transapical).
- PSV percutaneous heart valve
- the present invention aims at providing the cardiologist or surgeon with better information during percutaneous heart valve implantation.
- a method comprises the following steps. First, at least one image of the vessel root region, e.g. aortic root or pulmonary root region, is acquired with injected contrast agent. Then vessel information data within the at least one acquired image is identified. Further, a vessel root representation is modelled using the vessel information data. Then at least one current fluoroscopy image of the vessel root region is acquired. By combining the at least one fluoroscopy image with the model of the vessel root representation, the composite image is then generated. Next, the composite image is displayed on a display.
- the vessel root region e.g. aortic root or pulmonary root region
- the composite image displays the current situation in form a of greyscale fluoroscopy image in relation to the vessel root representation.
- the location and orientation of the artificial valve can be seen on this fluoroscopy image due to the frame parts of the artificial valve that provide enough contrast for the X-ray image.
- the relation to the vessel root, and of course also to the valve annulus, can easily be captured from the model of the vessel root representation that is combined with the fluoroscopy image.
- the user can adjust the positioning of the replacement valve for example through a catheter device, i.e.
- the model of the vessel root representation is in a way a sort of manipulated image data; that means the model stands for a higher level of information.
- Combining the model with the fluoroscopy image has the advantage that as little information of the fluoroscopy image as necessary is covered or erased by the additional image data during the composition, as all details on the fluoro image are important for the user.
- the composite image is a sort of hybrid image composed of fluoroscopy image data and an abstract model image data of the vessel root representation. No shading or covering of the fluoroscopy image takes place.
- the vessel image with the injected contrast agent is usually a pre-implant baseline vessel- graphy.
- the replacement valve can be roughly positioned before the contrast agent is injected.
- the device can then also be seen on the image.
- a vessel root model is shown in a fluoroscopy image on the display.
- the inventive method can easily be detected by its result.
- the present invention is also related to the replacement of other types of heart valves, such as pulmonary, mitral and tricuspid valves.
- the pulmonary valve is rather similar to the aortic valve in that it links a ventricle (right) to a main artery (pulmonary).
- the following description of the invention is focussed on the aortic valve, but the same can be applied to the pulmonary valve.
- the other two valves are atrio -ventricular valves (linking one atrium (left or right) to the ventricle on the same side (left or right).
- the mitral valve (on the left side) is also very important.
- the inventive model always amounts to produce a simplified structure of the valve's surrounding anatomy as displayed in a CA- filled sequence, and the composite image principle remains the same.
- aortic root region may be used for vessel root region. It is to be noted that this term is also understood as valve-vicinity. Further, the term aortic information data may be used for vessel information data or valve-vicinity data and the term aortic root representation may stand for vessel root representation or valve-vicinity representation.
- aorta the scope of the invention covers all type of heart valves as well. That is, the invention is also related to (and thus applicable) to atrio -ventricular valves (mitral, tricuspid) that link two chambers and not one chamber to one vessel. Hence, the term valve- vicinity covers all four cardiac valves.
- the roadmapping process can be achieved with hardly any manual intervention.
- no region- of-interest placement, and no clicking process designating the aortic root is involved.
- the vessel root outline is detected in the at least one acquired image as vessel information data.
- the outline of the aorta root i.e. the vessel root
- the outline has the advantage that it can easily be combined with other image data without covering or erasing too much information within this other image data.
- the outline still provides the surgeon with enough information for a correct positioning of the artificial valve to be deployed.
- the outline detection can be achieved by using medial-axis transforms or similar techniques.
- the vessel root region is segmented from the acquired image as vessel information data.
- the segmentation of the vessel root region is an alternative or complementary step for providing vessel information data.
- the segmentation can be applied to the full vessel root region. This can be achieved through purely region based techniques or the formable contour approaches, etc.
- the advantage is that the surgeon can be provided with additional information about the vessel situation in direct relation to the artificial valve or implant device.
- the segmentation can be achieved through purely region-based techniques or deformable contour approaches, etc.
- a sequence of images of the vessel root region is acquired with injected contrast agent and the image with the best contrast is selected for the step of identifying the vessel information data.
- This enables an improved modelling of the vessel or aortic root representation because the image data used for identifying the vessel or aortic information data provides more information when the contrast is better compared to an image with a low contrast.
- the selection can automatically be performed be filtering techniques and temporal histogram analysis, for example.
- the background in the at least one image is estimated and subtracted from the image before identifying the vessel information data.
- an image is achieved with data information focused on the step of identifying the vessel or aortic information data.
- the image used for further steps is reduced to the only information actually needed, which also improves the modelling step for achieving a vessel root representation.
- pre-operative data like the segmentation of the aortic root in a CT volume for example, could be used to help the detection of the segmentation of the vessel outline in the angiographic image. This can be applied alternatively or in addition to the DSA described above.
- a so-called non-intrusive model is generated, or produced respectively, for the implantation area. That means, a model is generated where the area of special interest, i.e. the area where the implant will be located, is reduced to only the basic information, or even better where no information is shown in that area to allow for a better view of the implant.
- the aortic root representation i.e. the model of the vessel root, is used for measuring, checking and rating purposes.
- the model is not only used for generating a composite image but also used for other purposes supporting the cardiologist or cardiac surgeon.
- This may also include automatic geometric measurements, such as annulus dimensions, leaflet plane orientations, etc, that can be stored for further purposes, such as controlling examinations at a later time or even adjusting or adapting the replacement valve device.
- the object is also reached with an examination apparatus for automatic road mapping for heart valve replacement that comprises at least one X-ray image acquisition device, a calculation unit and a display device.
- the image acquisition device is adapted to acquire at least one X-ray image of the vessel root region of a heart with injected contrast agent and to acquire at least one current fluoroscopy image of the vessel root region with a replacement valve inserted into the aorta.
- the calculation unit is adapted to identify vessel information data within the at least one acquired image, to model vessel root representation using the vessel information data and to generate a composite image by a combination of the model of the vessel root representation with the at least one fluoroscopy image.
- the display unit is adapted to display the composite image.
- the examination apparatus supplies the surgeon or cardiologist with improved information concerning the exact positioning of the artificial heart valve.
- the information in form of a composite image can easily be received by the surgeon and easily understood because the relation of the artificial valve and the vessel root region, e.g. the aortic root region, can be extracted directly from the image. In fact, additional abstracting mental processes by the surgeon are not necessary.
- the examination apparatus facilitates the heart valve replacement operation.
- the inventive apparatus can easily be detected, because as a result a fluoroscopy image is displayed that also shows a vessel root model.
- the invention also provides an X-ray imaging system with an examination apparatus according to the above mentioned embodiment and according to the embodiment defined by a claim.
- the imaging system also includes a resting surface for the object to be examined.
- the invention also relates to a catheterization laboratory system with an examination apparatus according to the invention.
- a computer readable medium in which a computer program for automatic road mapping for heart valve replacement is stored which, when being executed by a processor, causes the processor to carry out the above mentioned method steps.
- a computer program element for automatic road mapping for heart valve replacement which, when being executed by a processor, causes the processor to carry out the above mentioned method steps.
- the method of automatic road mapping for heart valve replacement may be embodied as a computer program, i.e. by software, or may be embodied using one or more special electronic optimization circuits, i.e. in hardware, or the method may be embodied in hybrid form, i.e. by means of software components and hardware components.
- This exemplary embodiment of the invention covers both a computer program that right from the beginning uses the invention and a computer program that by means of an update turns an existing program into a program that uses the invention. Further on, the computer program element might be able to provide all necessary steps to fulfil the procedure of the method as described above.
- a medium for making a computer program element available for downloading is provided, which computer program element is arranged to perform the method according to one of the previously described embodiments of the invention.
- existing imaging systems can be upgraded with a new software, which, when being executed by a processor, causes the system to carry out the above mentioned method steps.
- Fig. 1 shows an X-ray imaging system for the use in a catheterization laboratory.
- Fig. 2 schematically describes the method steps according to the invention.
- Fig. 3 schematically describes the anatomy of the aortic root.
- Fig. 4 describes possible elements of the aortic root model.
- Fig. 5 schematically shows a composite image according to the invention.
- Fig. 6 schematically shows the structure of the aorta.
- Fig. 7 schematically shows a catheterization of an object for a valve replacement.
- aortic root region is used instead of vessel root region or valve vicinity (area surrounding the annulus that is visible after contrast injection; this can be a vessel root (aortic, pulmonary), and / or the annulus walls on the surface of one or two cardiac chambers)
- aortic information data instead of vessel information data
- aortic root representation also stands for vessel root representation.
- FIG 6a heart 110 is shown with a right part 112 and a left part 114 in relation to the main vessels.
- the right part 112 is placed on the vena cava in the diagram. It should designate the part of the heart irrigated by the right coronary.
- On top of the left part an ascending aorta 116 can be seen.
- the ascending aorta 116 is forming an arch 118 where several other vessels 120 are connected to the aorta 116.
- the aorta 116 then leads downwards where several further vessels are connected, such as the celiac artery 122 and the superior mesenteric artery.
- the aorta splits up into the renal arteries 126 and the inferior mesenteric artery 128 that leads to the iliac arteries 130. This part is also called the abdominal aorta.
- two coronary arteries 133 are connected in the root region 130.
- An aortic heart valve (not shown) is located at the root 132.
- a valve delivery catheter 134 is inserted in the groin into one of the iliac arteries 130 and threaded up to the heart valve to be replaced (see fig. 7). In other words, the catheter 134 follows the aorta passing the arch 118 until it reaches the root region where the valve is deployed after correct positioning.
- FIG. 1 schematically shows an X-ray imaging system 10 for the use in a catheterization laboratory with an examination apparatus for automatic roadmapping for heart valve replacement.
- the examination apparatus comprises an X-ray image acquisition device with a source of X-ray radiation 12 provided to generate X-ray radiation.
- a table 14 is provided to receive a subject to be examined.
- an X-ray image detection module 16 is located opposite the source of X-ray radiation 12, i.e. during the radiation procedure, the subject is located between the source of X-ray radiation 12 and the detection module 16.
- the latter is sending data to a data processing unit or calculation unit 18, which is connected to both the detection module 16 and the radiation source 12.
- the calculation unit 18 is located underneath the table 14 to save space within the catheterization laboratory.
- a display device 20 is arranged in the vicinity of the table 14 to display information to the person operating the X-ray imaging system, i.e. a clinician such as a cardiologist or cardiac surgeon.
- the display device 20 is movably mounted to allow for an individual adjustment depending on the examination situation.
- an interface unit 22 is arranged to input information by the user.
- the image detection module 16 generates images by exposing the subject to X-ray radiation, wherein said images are further processed in the data processing unit 18. It is noted that the example shown is of a so-called C-type X-ray image acquisition device.
- the invention also relates to other types of X-ray image acquisition devices. The procedure according to the invention is described in more detail below.
- Fig. 2 schematically shows a flowchart of the steps, according to the invention.
- aortogram consists of a sequence of images that are taken by an X-ray imaging device of an object of interest which in the case of an aortogram is of course the aorta itself. These images are acquired after a contrast agent (CA) is injected into the aorta in order to make the volume of the aorta visible in an X-ray image.
- CA contrast agent
- the aorta can be seen in an X-ray image without a contrast agent, but the contrast agent provides a better visual detectability of the aorta.
- aortogram stands for a sequence with a contrast agent injected into a vessel (or heart chamber) to visualize an anatomic location or surrounding of a valve heart.
- vesselgram or angiogram can also be used.
- valvologram is also suitable for the description of the above mentioned sequence of images concerning valves of the heart.
- aortic information data is identified within the at least one acquired image.
- the aortic information data is then used for modelling an aortic root representation in a modelling step 36.
- the aortogram image or images can be refined before modelling the aortic root representation. For example, after the aortogram acquisition 32, an image with the best contrast for identifying aortic information data is selected in a selection step 37. The selected image with the best contrast is then used in the identifying step 34.
- the aortic root outline is detected in the selected image.
- the selected image is used in a segmentation step 40 where the aortic root region is segmented from the acquired image as the aortic information data.
- the aortogram is processed in a subtraction step 42 where a background is estimated in the at least one image or the image sequence and a digital subtraction angiogram (DSA) is performed for subtracting the background from the image before using the image data in the identifying step 34.
- DSA image can be used in the detection step 38 for detecting the root outline and for the segmentation step 40 for segmenting the root region.
- the result of the identification step 34 i.e. the root outline and/or the root region, is then used in the modelling step 36.
- the aortic information data is used for modelling the aortic root representation.
- the aortic root representation is basically consisting of image data representing a model of the aorta itself.
- the aortic root representation comprises an annulus model, i.e. the annulus plane of the aorta.
- the model can comprise curve definitions and/or vector data.
- the model represents a far more enhanced image data than only image pixels as is the case in the acquired image at the beginning. So to speak, the aortic root representation is image information on a higher level than the acquired pixel image from the aortogram at the beginning.
- the aortic root representation is then used in a composite image generating step 44 where the composite image is generated.
- the aortogram acquisition 32 and the further processing steps are usually achieved before placing the replacement valve at its location at the aorta root.
- fluoroscopy images are acquired in a fluoro acquisition step 46. These X-ray images show the replacement valve due to the frame parts used in the replacement valve. When using, for example, material from pigs or bovine / ovine for the valve leaflets, these cannot be seen in the fluoro image. But the detectable frame construction gives enough information for the location and orientation of the replacement valve.
- the fluoro images resulting from the acquisition step 46 are combined with the model of the aortic root representation. Hence, in the combining step 44 a composite image is generated that can then be displayed on a display during the device implantation 46.
- the displayed composite image provides the cardiac surgeon or cardiologist with the information needed for a correct deployment of the artificial valve. For actual, respectively current, information it is possible to repeat the fluoroscopy image acquisition 46 in a pre-determined interval. Usually, the fluoroscopy acquisition step 46 is undertaken without the use of contrast agent. By providing the surgeon with the composite image in the display step 46, it is possible to reduce the amount of contrast agent used during the procedure, which means a great relief for patients who have liver problems.
- aortogram acquisition 32 it is also possible to repeat the aortogram acquisition 32 and the following steps for modelling the aortic root representation 36 at a pre-determined rate or according to the actual need, for example, in case a procedure takes longer than actually expected.
- this model for measuring, checking and rating the aortic root representation itself in a further checking and exploitation step 50. For example, this can be undertaken on demand or also by automatic measurements 52 providing the surgeon with information that is necessary or that can be used in further treatment or preparation steps.
- the aortic root representation By combining the aortic root representation with a fluoro acquisition image in the composite step 44 it is possible to provide the surgeon with the most possible amount of information. Amongst others, this is because the information within the fluoro acquisition image is not erased or covered otherwise by simply overlaying pixels from the aortogram on to the fluoro acquisition image.
- the invention rather provides an aortic root representation where the fluoro acquisition image is nearly fully visible, for example, by showing the aortic root model in a colour that still allows the visibility of the underlying fluoro acquisition image in the composite image.
- the aortic root representation can consist of a detected aortic root outline that is manipulated in the further step of modelling, i.e., for example, the root outline is reduced to a one pixel line without interruptions or enclosures.
- the term of modelling the aortic root representation is understood in a rather broad way, i.e. the modelling may include the above mentioned preparation of the outline, but it can also comprise a more complex modelling such as a rendered or shaded representation of the aortic root to provide the surgeon with an image which provides the impression of a 3-dimensional model.
- the modelling is, of course, adapted to the fluoro acquisition image which is normally a greyscale or black and white X-ray image.
- the composite image is adapted for the best visibility and an easy detectability for the surgeon.
- FIG 3 a schematic illustration of an aorta root region 210 is shown, where an aorta 212 is ascending from a heart chamber 214.
- the aorta is having an annulus 216 at its bottom part providing the connection to the heart chamber 214. Slightly stream upwards from the annulus 216 there is connected to the aorta 212 a left coronary 218 and a right coronary 220. Further, the annulus 216 is shown in relation to its projected plane 224.
- FIG 3 is showing a root diagram according to the invention, there is also indicated an annulus projected diameter 226, a root projected diameter 230 and a projected diameter 232 of the ascending aorta 212.
- the aorta 212 is also having a so-called left and right sinus 234, 236.
- the left and right coronaries 218, 220 which are also known as ostia, open into the aorta with openings 238, 240 which should not be blocked with the replacement valve.
- the valve is usually located below the openings 238, 240 or its frame features a concave part that avoids the blocking of the coronary artery ostia.
- the information shown in the root diagram is processed to provide an aortic root model which is schematically shown in figure 4.
- the aorta 212 is shown with the modelled root outlines 242.
- the coronaries 216, 220 respectively ostia are also shown with their modelled outlines 244 only.
- the modelled annulus plane 224 is shown in a dashed line 246 to indicate that this is only a mere graphical display means.
- the model is modified such that there is non-intrusive model information in that specific area.
- This model is then combined with an X-ray image to form a composite image of which an example is shown in fig. 5a and 5b.
- the aortic root model described in figure 4 is computed in an aortagram (not shown).
- the result is then composed with a fluoroscopy image.
- the composite image is showing an aortic root model 250 which comprises the root outline 242 and the annulus plane 246.
- a replacement valve 252 with markers is shown in the time of positioning, i.e. the valve 252 is inserted in an unexpended state by the means of a delivery catheter 254.
- the same situation is shown at expansion time.
- the valve 252 with its base 256 is expended with a balloon.
- the composite image according to the invention shows that the device base 256 is well aligned with the annulus plane 246.
- the dark tube like device 258 is a TEE probe (Trans-Esophagus Echographic) arranged for separate aspects which are not related to the invention.
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Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
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EP09795554.6A EP2376013B8 (en) | 2008-12-12 | 2009-12-07 | Automatic road mapping for heart valve replacement |
CN200980149333.8A CN102245120B (en) | 2008-12-12 | 2009-12-07 | Automatic road mapping for heart valve replacement |
RU2011128732/14A RU2526567C2 (en) | 2008-12-12 | 2009-12-07 | Automatic creation of reference points for replacement of heart valve |
JP2011540302A JP5718820B2 (en) | 2008-12-12 | 2009-12-07 | Automatic road mapping for heart valve replacement |
US13/133,693 US10646184B2 (en) | 2008-12-12 | 2009-12-07 | Automatic road mapping for heart valve replacement |
Applications Claiming Priority (2)
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EP08305929 | 2008-12-12 | ||
EP08305929.5 | 2008-12-12 |
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WO2010067300A1 true WO2010067300A1 (en) | 2010-06-17 |
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ID=41800539
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PCT/IB2009/055547 WO2010067300A1 (en) | 2008-12-12 | 2009-12-07 | Automatic road mapping for heart valve replacement |
Country Status (6)
Country | Link |
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US (1) | US10646184B2 (en) |
EP (1) | EP2376013B8 (en) |
JP (1) | JP5718820B2 (en) |
CN (1) | CN102245120B (en) |
RU (1) | RU2526567C2 (en) |
WO (1) | WO2010067300A1 (en) |
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JPS6180931A (en) * | 1984-09-28 | 1986-04-24 | Oki Electric Ind Co Ltd | Signal distance calculation processing method |
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WO2024038054A1 (en) | 2022-08-16 | 2024-02-22 | Syngenta Crop Protection Ag | Fungicidal compositions |
Also Published As
Publication number | Publication date |
---|---|
EP2376013B1 (en) | 2020-03-04 |
JP2012511386A (en) | 2012-05-24 |
EP2376013A1 (en) | 2011-10-19 |
RU2011128732A (en) | 2013-01-20 |
US20110249794A1 (en) | 2011-10-13 |
CN102245120A (en) | 2011-11-16 |
CN102245120B (en) | 2014-08-13 |
RU2526567C2 (en) | 2014-08-27 |
US10646184B2 (en) | 2020-05-12 |
EP2376013B8 (en) | 2020-04-15 |
JP5718820B2 (en) | 2015-05-13 |
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