WO2007131619A1 - 4,5-diphenyl-pyrimidinyl-oxy oder -mercapto substituierte carbonsäuren, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel - Google Patents
4,5-diphenyl-pyrimidinyl-oxy oder -mercapto substituierte carbonsäuren, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel Download PDFInfo
- Publication number
- WO2007131619A1 WO2007131619A1 PCT/EP2007/003803 EP2007003803W WO2007131619A1 WO 2007131619 A1 WO2007131619 A1 WO 2007131619A1 EP 2007003803 W EP2007003803 W EP 2007003803W WO 2007131619 A1 WO2007131619 A1 WO 2007131619A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- alkyl
- inhibitors
- agonists
- formula
- compounds
- Prior art date
Links
- 0 *c1c(CCOc2ccc(CC(C(O)=*)C(c(cccc3)c3C(c3ccccc3)=O)=N)cc2)nc(-c2ccccc2)[o]1 Chemical compound *c1c(CCOc2ccc(CC(C(O)=*)C(c(cccc3)c3C(c3ccccc3)=O)=N)cc2)nc(-c2ccccc2)[o]1 0.000 description 3
- PKNYXWMTHFMHKD-UHFFFAOYSA-N CC(C)(C(O)=O)Sc1ccc(CCN(CCCCC2CCCCC2)C(NC2CCCCC2)=O)cc1 Chemical compound CC(C)(C(O)=O)Sc1ccc(CCN(CCCCC2CCCCC2)C(NC2CCCCC2)=O)cc1 PKNYXWMTHFMHKD-UHFFFAOYSA-N 0.000 description 1
- VRHOBXXCNBZJRX-UHFFFAOYSA-N CCC(Cc(cc1)cc(C(NCc(cc2)ccc2Oc(cc2)ccc2F)=O)c1OC)C(O)=O Chemical compound CCC(Cc(cc1)cc(C(NCc(cc2)ccc2Oc(cc2)ccc2F)=O)c1OC)C(O)=O VRHOBXXCNBZJRX-UHFFFAOYSA-N 0.000 description 1
- KWSPYUOBNIMILB-SANMLTNESA-N C[C@](Cc(cc1)ccc1OCCc1c(C)[o]c(-c2ccc[s]2)n1)(C(O)=O)Oc1ccccc1 Chemical compound C[C@](Cc(cc1)ccc1OCCc1c(C)[o]c(-c2ccc[s]2)n1)(C(O)=O)Oc1ccccc1 KWSPYUOBNIMILB-SANMLTNESA-N 0.000 description 1
- XMSXOLDPMGMWTH-UHFFFAOYSA-N C[n]1c(cc(cc2)OC)c2nc1COc1ccc(CC(C(N2)=O)SC2=O)cc1 Chemical compound C[n]1c(cc(cc2)OC)c2nc1COc1ccc(CC(C(N2)=O)SC2=O)cc1 XMSXOLDPMGMWTH-UHFFFAOYSA-N 0.000 description 1
- YDBLKRPLXZNVNB-UHFFFAOYSA-N Cc1c(CSc(cc2C)ccc2OCC(O)=O)[s]c(-c2ccc(C(F)(F)F)cc2)n1 Chemical compound Cc1c(CSc(cc2C)ccc2OCC(O)=O)[s]c(-c2ccc(C(F)(F)F)cc2)n1 YDBLKRPLXZNVNB-UHFFFAOYSA-N 0.000 description 1
- GPCJDSXBRMKASP-UHFFFAOYSA-N OC(C(CCCCCCCCCCc(cc1)ccc1Cl)(Cl)Cl)=O Chemical compound OC(C(CCCCCCCCCCc(cc1)ccc1Cl)(Cl)Cl)=O GPCJDSXBRMKASP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
Definitions
- the invention relates to 4,5-diphenyl-pyrimidinyl-oxy or -mercapto substituted carboxylic acids and their physiologically acceptable salts.
- the invention had the object to provide compounds that develop a therapeutically useful effect.
- the object was to find new compounds which are suitable for the treatment of hyperglycemia and diabetes.
- the invention therefore relates to compounds of the formula I,
- Rl, R2 are each independently (Ci-C 6) -alkyl, O- (Ci-C 6) -alkyl, NH 2, NH (Ci-C4) - alkyl, N [(Ci-C 4) alkyl] 2 , OH, CN, F, Cl, Br, O-phenyl, CF 3 , OCF 3 or OCH 3 , wherein alkyl may be mono- or polysubstituted by F, Cl, Br or CN;
- n 0, 1, 2, 3, 4 or 5
- m 0, 1, 2, 3, 4 or 5;
- Alkylene, alkenylene and alkynylene may be substituted one or more times with R3;
- Y bond (Ci-C4) - alkylene, (C 2 -C 4) -alkenylene or (C 2 -C 4) -alkynylene, may be substituted with R3 multiply said alkylene, alkenylene and alkynylene or;
- R3 NH 2, NH (C, -C 4) - alkyl, N [(C, -C 4) alkyl] 2, F, Cl, Br, CN, OH, O- (C, -C 6) alkyl .
- alkyl, alkenyl and alkynyl may be mono- or polysubstituted by F, Cl, Br or CN;
- R 4 is F, Cl, Br, CN, (C 1 -C 4 ) -alkyl or O- (C 1 -C 4 ) -alkyl, where alkyl may be mono- or polysubstituted by F, Cl, Br or CN;
- R 1, R 2 independently of one another are (C 1 -C 6 ) -alkyl, O- (C 1 -C 6 ) -alkyl, NH 25 NH (C 1 -C 4 ) -
- n 0, 1, 2, 3, 4 or 5;
- Y bond (Ci-C4) - alkylene, (C 2 -C 4) -alkenylene or (C 2 -C 4) -alkynylene, may be substituted with R3 multiply said alkylene, alkenylene and alkynylene or;
- R 3 is NH 2 , NH (C 1 -C 4 ) -alkyl, N [(C 1 -C 4 ) -alkyl] 2 , F, Cl, Br, CN, OH, O- (C 1 -C 6 ) -alkyl .
- alkyl, alkenyl and alkynyl may be mono- or polysubstituted by F, Cl, Br or CN;
- R4 F, Cl, Br, CN, (C r C4) alkyl or O- (C, -C 4) - alkyl, where alkyl may be substituted one or more times by F, Cl, Br or CN;
- R 1, R 2 independently of one another (C 1 -C 6 ) -alkyl, O- (C 1 -C 6 ) -alkyl, OH, CN, F, Cl, Br,
- n 0, 1, 2, 3, 4 or 5;
- n 0, 1, 2, 3, 4 or 5;
- R 4 is F, Cl, Br, CN, (C 1 -C 4 ) -alkyl or O- (C 1 -C 4 ) -alkyl;
- R 1, R 2 independently of one another (C 1 -C 6 ) -alkyl, O- (C 1 -C 6 ) -alkyl, OH, CN, F, Cl, Br, O---
- radicals or substituents can occur several times in the compounds of the formula I, they may all independently of one another have the stated meaning and be identical or different.
- alkyl, alkenyl, alkynyl, alkylene, alkenylene and alkynylene radicals in the radicals W, Y R1, R2, R3 and R4 can be both straight-chain and branched.
- the invention relates to compounds of the formula I in the form of their salts, racemates, racemic mixtures and pure enantiomers and their diastereomers and mixtures thereof.
- Physiologically acceptable salts are particularly suitable for medical applications due to their higher water solubility compared to the starting or basic compounds. These salts must have a physiologically acceptable anion or cation.
- Suitable physiologically acceptable acid addition salts of the compounds according to the invention are salts of inorganic acids, such as hydrochloric acid, hydrobromic acid, phosphoric, metaphosphoric, nitric, sulfonic and sulfuric acid and organic acids, such as.
- the chloro salt is used in a particularly preferred manner.
- Suitable physiologically acceptable basic salts are ammonium salts, alkali metal salts (such as sodium and potassium salts), alkaline earth salts (such as magnesium and calcium salts), zinc salts, trometamol (2-amino-2-hydroxymethyl-l, 3-propanediol), diethanolamine, lysine , Arginine, choline, meglumine or ethylenediamine salts. Salts with a non-physiologically acceptable anion or cation are also within the scope of the invention as useful intermediates for the preparation or purification of physiologically acceptable salts and / or for use in non-therapeutic, for example, in vitro applications.
- prodrugs of the compounds of the invention can be metabolized in vivo to a compound of the invention. These prodrugs may or may not be effective.
- the compounds of the invention may also be in various polymorphic forms, e.g. as amorphous and crystalline polymorphic forms. All polymorphic forms of the compounds of the invention are within the scope of the invention and are a further aspect of the invention.
- the compounds of formula I and their physiologically acceptable salts are ideal drugs for the treatment of elevated lipid concentrations in the blood, the metabolic enzymes, and their physiologically acceptable salts.
- Cardiovascular diseases and lipid metabolism disorders in particular of hyperlipidemia.
- the compound (s) of the formula (I) can also be administered in combination with other active substances.
- the amount of a compound of formula (I) required to achieve the desired biological effect is dependent upon a number of factors, eg, the specific compound chosen, the intended use, the mode of administration, and the clinical condition of the patient ,
- the daily dose ranges from 0.1 mg to 100 mg (typically from 0.1 mg to 50 mg) per day per kilogram of body weight, eg 0.1-10 mg / kg / day.
- tablets or capsules may range from 0.01 to 100 mg, typically from 0.02 to 50 mg.
- the compounds according to formula (I) may themselves be used as compound, but they are preferably present with a tolerable carrier in the form of a pharmaceutical composition.
- the carrier must of course be compatible in the sense that it is compatible with the other ingredients of the composition and is not harmful to the patient.
- the carrier may be a solid or a liquid, or both, and is preferably formulated with the compound as a single dose, for example, as a tablet, which may contain from 0.05% to 95% by weight of the active ingredient.
- Other pharmaceutically active substances may also be present, including further compounds according to formula (I).
- the pharmaceutical compositions according to the invention can be prepared by one of the known pharmaceutical methods, which consist essentially in that the ingredients are mixed with pharmacologically acceptable carriers and / or excipients.
- compositions according to the invention are those which are suitable for oral and peroral (eg sublingual) administration, although the most suitable mode of administration in each individual case is dependent on the nature and severity of the condition to be treated and on the nature of the particular compound of formula (I) used , Also coated formulations and coated slow release formulations are within the scope of the invention. Preference is given to acid and enteric formulations. Suitable enteric coatings include cellulose acetate phthalate, polyvinyl acetate phthalate, hydroxypropylmethylcellulose phthalate and anionic polymers of methacrylic acid and methyl methacrylate.
- Suitable pharmaceutical preparations for oral administration may be in separate units, such as capsules, cachets, lozenges or tablets, each containing a certain amount of the compound of formula (I); as a powder or granules; as a solution or suspension in an aqueous or non-aqueous liquid; or as an oil-in-water or water-in-oil emulsion.
- these compositions may be prepared by any suitable pharmaceutical method comprising a step of contacting the active ingredient and the carrier (which may consist of one or more additional ingredients).
- the compositions are prepared by uniformly and homogeneously mixing the active ingredient with a liquid and / or finely divided solid carrier, after which the product is molded, if necessary.
- a tablet can be made by compressing or molding a powder or granules of the compound, optionally with one or more additional ingredients.
- Pressed tablets may be prepared by tableting the compound in free-flowing form, such as a powder or granules, optionally mixed with a binder, lubricant, inert diluent and / or surfactant / dispersant in a suitable machine.
- Molded tablets may be prepared by shaping the powdered compound moistened with an inert liquid diluent in a suitable machine.
- compositions suitable for peroral (sublingual) administration include lozenges containing a compound of formula (I) with a flavoring, usually sucrose and gum arabic or tragacanth, and lozenges containing the compound in an inert base such as gelatin and glycerine or sucrose and gum arabic.
- the compounds according to the invention can be administered alone or in combination with one or more further pharmacological active ingredients which, for example, have beneficial effects on metabolic disorders or frequently associated diseases.
- further pharmacological active ingredients which, for example, have beneficial effects on metabolic disorders or frequently associated diseases. Examples of such medications are
- hypoglycaemic drugs antidiabetics
- antithrombotic agents agents for the treatment of hypertension
- the administration of the drug combination may be either by separate administration of the drugs to the patient or in the form of combination products where multiple drugs are present in a pharmaceutical preparation.
- Particularly suitable as further active ingredients for the combination preparations are: all antidiabetics which are mentioned in the Red List 2006, Chapter 12; all weight loss / appetite suppressants listed in the Red List 2006, Chapter 1; all lipid-lowering drugs mentioned in the Red List 2006, chapter 58. They can be combined with the compound of the formula I according to the invention in particular for the synergistic effect improvement.
- the administration of the active ingredient combination can be carried out either by separate administration of the active ingredients to the patient or in the form of combination preparations in which several active ingredients are present in a pharmaceutical preparation. Most of the drugs listed below are disclosed in USP Dictionary of USAN and International Drug Names, US Pharmacopeia, Rockville 2001.
- Antidiabetics include insulin and insulin derivatives, such as Lantus ® (see www.lantus.com) or HMR 1964 or those as described in WO2005005477 (Novo Nordisk), fast-acting insulins (see US No. 6,221,633), inhalable insulins such. Exubera or oral insulins such.
- GLP-I derivatives such as exenatide, liraglutide or those described in WO 98/08871 or WO2005027978 of Novo Nordisk A / S, in WO 01/04156 by Zealand or WO 00/34331 to Beaufour-Ipsen, Pramlintide Acetate (Symlin; Amylin Pharmaceuticals), as well as orally active hypoglycemic agents.
- the orally active hypoglycemic agents preferably comprise sulfonylureas,
- Glucokinase activators inhibitors of fructose 1, 6-bisphosphatase
- Potassium channel opener e.g. those disclosed in WO 97/26265 and WO 99/03861 by Novo Nordisk A / S,
- DPP-IV dipeptidyl peptidase-IV
- PTPlB protein tyrosine phosphatase-1B
- Modulators of the sodium-dependent glucose transporter 1 or 2 (SGLT1, SGLT2), fat metabolism-altering compounds such as antihyperlipidemic agents and antilipidemic agents,
- the compound of the formula I is administered in combination with an HMGCoA reductase inhibitor, such as simvastatin, fluvastatin, pravastatin, lovastatin, atorvastatin, cerivastatin, rosuvastatin or L-659699.
- an HMGCoA reductase inhibitor such as simvastatin, fluvastatin, pravastatin, lovastatin, atorvastatin, cerivastatin, rosuvastatin or L-659699.
- the compound of the formula I is administered in combination with a cholesterol absorption inhibitor, such as e.g. Ezetimibe, Tiqueside, Pamaqueside, FM-VP4 (sitostanol / campesterol ascorbyl phosphate; Forbes Medi-Tech, WO2005042692), MD-0727 (Microbia Inc., WO2005021497) or with compounds as described in WO2002066464 (Kotobuki Pharmaceutical Co. Ltd.), WO2005062824 (Merck & Co.) or WO2005061451 and WO2005061452 (AstraZeneca AB).
- a cholesterol absorption inhibitor such as e.g. Ezetimibe, Tiqueside, Pamaqueside, FM-VP4 (sitostanol / campesterol ascorbyl phosphate; Forbes Medi-Tech, WO2005042692), MD-0727 (Microbia Inc., WO2005021497) or with compounds as described in WO2002066464 (K
- the compound of the formula I is administered in combination with a PPAR gamma agonist, such as e.g. Rosiglitazone, pioglitazone, JTT-501, Gl 262570, R-483 or CS-Ol 1 (rivoglitazone).
- a PPAR gamma agonist such as e.g. Rosiglitazone, pioglitazone, JTT-501, Gl 262570, R-483 or CS-Ol 1 (rivoglitazone).
- the compound of formula I is administered in combination with a PPAR alpha agonist, e.g. GW9578, GW-590735, K-11 1, LY-674, KRP-101 or DRF-10945.
- a PPAR alpha agonist e.g. GW9578, GW-590735, K-11 1, LY-674, KRP-101 or DRF-10945.
- the compound of formula I is used in combination with a mixed PPAR alpha / gamma agonist, e.g. Muraglitazar, Tesaglitazar, Naveglitazar, LY-510929, ONO-5129, E-3030, AVE 8042, AVE 8134, AVE 0847 or as in PCT / US 00/1 1833, PCT / US 00/1 1490, DE 10142734.4 or in JP Berger et al., TRENDS in Pharmacological Sciences 28 (5), 244-251, 2005.
- a mixed PPAR alpha / gamma agonist e.g. Muraglitazar, Tesaglitazar, Naveglitazar, LY-510929, ONO-5129, E-3030, AVE 8042, AVE 8134, AVE 0847 or as in PCT / US 00/1 1833, PCT / US 00/1 1490, DE 10142734.4 or in JP Berger
- the compound of formula I is used in combination with a PPAR delta agonist, e.g. GW-501516 administered.
- a PPAR delta agonist e.g. GW-501516 administered.
- the compound of formula I is administered in combination with metaglidases or with MBX-2044 or other partial PPAR gamma agonist / antagonist. In one embodiment of the invention, the compound of formula I is administered in combination with a fibrate, such as fenofibrate, clofibrate or bezafibrate.
- the compound of formula I is used in combination with an MTP inhibitor, e.g. Implitapide, BMS-201038, R-103757 or those described in WO2005085226.
- an MTP inhibitor e.g. Implitapide, BMS-201038, R-103757 or those described in WO2005085226.
- the compound of formula I is used in combination with a CETP inhibitor, e.g. Torcetrapib or JTT-705.
- a CETP inhibitor e.g. Torcetrapib or JTT-705.
- the compound of formula I is used in combination with a bile acid resorption inhibitor (see, for example, US 6,245,744, US 6,221,897 or WO00 / 61568), e.g. HMR 1741 or as described in DE 10 2005 033099.1 and DE 10 2005 033100.9.
- a bile acid resorption inhibitor see, for example, US 6,245,744, US 6,221,897 or WO00 / 61568
- HMR 1741 e.g. HMR 1741 or as described in DE 10 2005 033099.1 and DE 10 2005 033100.9.
- the compound of formula I is used in combination with a polymeric bile acid adsorber, e.g. Cholestyramine or colesevelam.
- a polymeric bile acid adsorber e.g. Cholestyramine or colesevelam.
- the compound of formula I is used in combination with an LDL receptor inducer (see US 6,342,512), e.g. HMRI 171, HMR1586 or those described in WO2005097738.
- an LDL receptor inducer see US 6,342,512
- the compound of formula I is administered in combination with Omacor® (omega-3 fatty acids, high-concentration ethyl esters of eicosapentaenoic acid and docosahexaenoic acid).
- Omacor® omega-3 fatty acids, high-concentration ethyl esters of eicosapentaenoic acid and docosahexaenoic acid.
- the compound of the formula I is administered in combination with an ACAT inhibitor, such as avasimibe.
- the compound of the formula I is administered in combination with an antioxidant, for example OPC-14117, probucol, tocopherol, ascorbic acid, ⁇ -carotene or selenium.
- the compound of the formula I in combination with a vitamin, such as. As vitamin B6 or vitamin B12 administered.
- the compound of the formula I is administered in combination with a lipoprotein-lipase modulator, e.g. Ibrolipim (NO-1886).
- a lipoprotein-lipase modulator e.g. Ibrolipim (NO-1886).
- the compound of formula I is used in combination with an ATP citrate lyase inhibitor, e.g. SB-204990 administered.
- an ATP citrate lyase inhibitor e.g. SB-204990 administered.
- the compound of formula I is used in combination with a squalene synthetase inhibitor, e.g. BMS-188494 or as described in WO2005077907.
- a squalene synthetase inhibitor e.g. BMS-188494 or as described in WO2005077907.
- the compound of formula I is administered in combination with a lipoprotein (a) antagonist, e.g. Gemcabene (CI-1027).
- a lipoprotein (a) antagonist e.g. Gemcabene (CI-1027).
- the compound of formula I in combination with an HM74A receptor agonist such as e.g. Nicotinic acid administered.
- the compound of formula I is administered in combination with a lipase inhibitor, e.g. Orlistat or cetilistat (ATL-962).
- a lipase inhibitor e.g. Orlistat or cetilistat (ATL-962).
- the compound of the formula I is administered in combination with insulin.
- the compound of the formula I is administered in combination with a sulfonylurea, such as, for example, tolbutamide, glibenclamide, glipizide or glimepiride.
- a sulfonylurea such as, for example, tolbutamide, glibenclamide, glipizide or glimepiride.
- the compound of the formula I is administered in combination with a biguanide, such as, for example, metformin.
- the compound of formula I is used in combination with a meglitinide, e.g. Repaglinide or nateglinide.
- a meglitinide e.g. Repaglinide or nateglinide.
- the compound of formula I is used in combination with a thiazolidinedione, e.g. Troglitazone, ciglitazone, pioglitazone, rosiglitazone or those described in WO 97/41097 by Dr. med. Reddy's Research Foundation disclosed compounds, particularly 5 - [[4 - [(3,4-dihydro-3-methyl-4-oxo-2-quinazolinylmethoxy) phenyl] methyl] -2,4-thiazolidinedione.
- the compound of the formula I is administered in combination with an ⁇ -glucosidase inhibitor, e.g. Miglitol or acarbose, administered.
- an ⁇ -glucosidase inhibitor e.g. Miglitol or acarbose
- the compound of formula I is administered in combination with an agent which acts on the ATP-dependent potassium channel of the beta cells, e.g. Tolbutamide, glibenclamide, glipizide, glimepiride or repaglinide.
- an agent which acts on the ATP-dependent potassium channel of the beta cells e.g. Tolbutamide, glibenclamide, glipizide, glimepiride or repaglinide.
- the compound of formula I is used in combination with more than one of the aforementioned compounds, e.g. in combination with a sulfonylurea and metformin, a sulfonylurea and acarbose, repaglinide and metformin, insulin and a sulfonylurea, insulin and metformin, insulin and troglitazone, insulin and lovastatin, etc.
- the compound of formula I is used in combination with an inhibitor of glycogen phosphorylase, e.g. PSN-357 or FR-258900 or those described in WO2003084922, WO2004007455, WO2005073229-31 or WO2005067932.
- an inhibitor of glycogen phosphorylase e.g. PSN-357 or FR-258900 or those described in WO2003084922, WO2004007455, WO2005073229-31 or WO2005067932.
- the compound of formula I is administered in combination with glucagon receptor antagonists such as A-770077, NNC-25-2504 or as described in WO2004100875 or WO2005065680.
- glucagon receptor antagonists such as A-770077, NNC-25-2504 or as described in WO2004100875 or WO2005065680.
- the compound of the formula I in combination with activators of glucokinase such. RO-4389620, LY-2121260 (WO2004063179), PSN-105, PSN-1 10, GKA-50, or those as described e.g.
- the compound of the formula I in combination with an inhibitor of gluconeogenesis, such as. FR-225654.
- the compound of formula I is used in combination with inhibitors of fructose 1,6-bisphosphatase (FBPase), e.g. CS-917 administered.
- FBPase fructose 1,6-bisphosphatase
- the compound of formula I is used in combination with modulators of glucose transporter-4 (GLUT4), e.g. KST-48 (D.O. Lee et al .: Arzneim.-Forsch.drug Res. 54 (12), 835 (2004)).
- GLUT4 glucose transporter-4
- KST-48 D.O. Lee et al .: Arzneim.-Forsch.drug Res. 54 (12), 835 (2004).
- the compound of the formula I in combination with inhibitors of glutamine-fructose-6-phosphate amidotransferase (GFAT), as z. As described in WO2004101528 administered.
- GFAT glutamine-fructose-6-phosphate amidotransferase
- the compound of the formula I in combination with inhibitors of dipeptidyl peptidase-IV in combination with inhibitors of dipeptidyl peptidase-IV (DPP-IV), such.
- DPP-IV dipeptidyl peptidase-IV
- the compound of the formula I in combination with inhibitors of protein tyrosine phosphatase 1 B (PTPlB), as z.
- PTPlB protein tyrosine phosphatase 1 B
- the compound of formula I is used in combination with modulators of the sodium-dependent glucose transporter 1 or 2 (SGLT1, SGLT2), e.g. KGA-2727, T-1095, SGL-0010, AVE 2268 and SAR 7226, or as described e.g. In WO2004007517, WO200452903, WO200452902, PCT / EP2005 / 005959, WO2005085237, JP2004359630 or by A.L. Handion in Expert Opin. Ther. Patents (2005) 15 (11), 1531-1540.
- SGLT1, SGLT2 the sodium-dependent glucose transporter 1 or 2
- the compound of the formula I in combination with inhibitors of hormone-sensitive lipase (HSL), such as. As described in WO2005073199 administered.
- HSL hormone-sensitive lipase
- the compound of the formula I in combination with inhibitors of acetyl-CoA carboxylase (ACC) such as in WO 199946262, WO200372197, WO2003072197 or WO2005044814.
- the compound of formula I is used in combination with an inhibitor of phosphoenolpyruvate carboxykinase (PEPCK), e.g. such as described in WO2004074288 administered.
- PPCK phosphoenolpyruvate carboxykinase
- the compound of the formula I in combination with an inhibitor of glycogen synthase kinase-3 beta (GSK-3 beta), such as.
- GSK-3 beta glycogen synthase kinase-3 beta
- GSK-3 beta glycogen synthase kinase-3 beta
- the compound of the formula I in combination with an inhibitor of the protein kinase C beta (PKC beta), such.
- PLC beta protein kinase C beta
- the compound of the formula I in combination with an endothelin A receptor antagonists, such as. B. avosentan (SPP-301).
- the compound of the formula I is administered in combination with inhibitors of the "I-kappaB kinase" (IKK inhibitors), as described, for example, in WO2001000610, WO2001030774, WO2004022553 or WO2005097129.
- IKK inhibitors inhibitors of the "I-kappaB kinase"
- the compound of the formula I in combination with modulators of the glucocorticoid receptor, as described, for. As described in WO2005090336 administered.
- the compound of the formula I is used in combination with CART modulators (see “***e amphetamine-regulated transcript Influenza energy metabolism, anxiety and gastric emptying in mice “Asakawa, A. et al .: Hormones and Metabolism Research (2001), 33 (9), 554-558);
- NPY antagonists e.g. Naphthalene-1-sulfonic acid ⁇ 4 - [(4-amino-quinazolin-2-ylamino) -methyl] -cyclohexylmethyl ⁇ -amide hydrochloride (CGP 71683A); Peptide YY 3-36 (PYY3-36) or analogous compounds, such as. CJC-1682 (PYY3-36 conjugated to human serum albumin via Cys34), CJC-1643 (derivative of PYY3-36 conjugated to serum albumin in vivo) or those described in WO2005080424; Cannabinoid receptor 1 antagonists, such as Rimonabant, SR 147778 or such as in z. EP 0656354, WO 00/15609, WO 02/076949, WO2005080345, WO2005080328,
- MC4 agonists eg 1-amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid [2- (3a-benzyl-2-methyl-3-oxo-2,3,3a, 4,6, 7-hexahydro-pyrazolo [4,3-c] pyridin-5-yl) -1- (4-chloro-phenyl) -2-oxo-ethyl] -amide (WO 01/91752) or LB53280, LB53279, LB53278 or THIQ, MB243, RY764, CHIR-785, PT-141 or those as described in WO2005060985, WO2005009950, WO2004087159, WO2004078717, WO2004078716, WO2004024720, US20050124652, WO2005051391, WO2004112793, WO200200222014, US20050176728, US20050164914, US20050124636, US
- Histamine H3 receptor agonists eg, 3-cyclohexyl-1- (4,4-dimethyl-1,4,6,7-tetrahydroimidazo [4,5-c] pyridin-5-yl) -propan-1 oxalic acid salt (WO 00/63208) or those as described in
- CRF antagonists eg [2-methyl-9- (2,4,6-trimethyl-phenyl) -9H-l, 3,9-triaza-fluoren-4-yl] -dipropyl-amine (WO 00/66585) );
- CRF BP antagonists e.g., urocortin
- Urocortin agonists e.g., ⁇ 3 agonists (such as, for example, 1- (4-chloro-3-methanesulfonylmethyl-phenyl) -2- [2- (2,3-dimethyl-1H-indol-6-yloxy) -ethyl-amino] -ethanol hydrochloride (WO 01 / 83451));
- MSH melanocyte-stimulating hormone
- MCH (melanin-concentrating hormone) receptor antagonists such as NBI-845, A-761, A-665798, A-798, ATC-0175, T-226296, T-71, GW-803430 or such compounds, as described in WO2003 / 15769, WO2005085200, WO2005019240, WO2004011438, WO2004012648,
- WO2003033476 WO2002006245, WO2002002744, WO2003004027 or FR2868780 are described); CCK-A agonists (such as ⁇ 2- [4- (4-chloro-2,5-dimethoxyphenyl) -5- (2-cyclohexyl-ethyl) -thiazol-2-ylcarbamoyl] -5,7-dimethyl indol-1-yl ⁇ acetic acid trifluoroacetic acid salt (WO
- Serotonin reuptake inhibitors e.g., dexfenfiuramines
- mixed serotonin and noradrenergic compounds e.g., WO 00/71549
- 5-HT receptor agonists e.g. 1- (3-ethyl-benzofuran-7-yl) -piperazine oxalic acid salt (WO
- 5-HT2C receptor agonists such as APD-356, BVT-933 or those as described in U.S. Pat
- WO2005082859 are described); 5-HT6 receptor antagonists, as e.g. in WO2005058858 are described;
- BTS-3 agonists Bombesin receptor agonists
- Galanin receptor antagonists eg, human growth hormone or AOD-9604;
- Growth Hormone Secretagogue Receptor Antagonists such as A-778193 or those as described in WO2005030734;
- TRH agonists see, e.g., EP 0 462 884; decoupling protein 2- or 3-modulators;
- Leptin agonists See, e.g., Lee, Daniel W., Leinung, Matthew C; Rozhavskaya Arena,
- DA agonists bromocriptine or doprexin
- Lipase / amylase inhibitors (as described, for example, in WO 00/40569);
- DGATs diacylglycerol O-acyltransferases
- Inhibitors of fatty acid synthase e.g. C75 or those as described in WO2004005277;
- the further active ingredient is leptin; see, e.g. "Perspectives in the therapeutic use of leptin", Salvador, Javier; Gomez-Ambrosi, Javier; Fruhbeck, Gema, Expert Opinion on Pharmacotherapy (2001), 2 (10), 1615-1622.
- the further active ingredient is dexamphetamine or amphetamine. In one embodiment of the invention, the further active ingredient is fenfluramine or dexfenfluramine.
- the further active ingredient is sibutramine.
- the further active ingredient is mazindol or phentermine.
- the compound of formula I in combination with bulking agents preferably insoluble bulking agents
- bulking agents preferably insoluble bulking agents
- Caromax is a carob-containing product of the company Nutrinova, Nutrition Specialties & Food Ingredients GmbH, Industriepark availability, 65926 Frankfurt / Main) administered.
- Combination with Caromax ® is possible in one preparation or by separate administration of compounds of the formula I and Caromax ®.
- Caromax ® can also be administered in the form of food, such as in baked goods or muesli bars.
- the invention furthermore relates to stereoisomer mixtures of the formula I as well as to the pure stereoisomers of the formula I and to diastereomer mixtures of the formula I and also to the pure diastereomers.
- the separation of the mixtures is carried out by chromatographic means.
- Functional assays were performed by FLIPR technique ("Fluorescence Imaging Plate Reader", Molecular Devices Corp.), using agonist-induced changes in the intracellular concentration of Ca 2+ in recombinant HEK293 cells expressing GPCR GPR40.
- the compounds of the formula I increase the activity at the GPR40 receptor and are therefore well suited for the treatment of hyperglycemia and diabetes.
- the compounds of the formula I increase the insulin secretion (see Itoh et al., Nature 422, 173-176).
- the compounds of the formula I can also show a corresponding effect on the GPRI 20 receptor.
- the compounds of the formula I can be prepared by reacting suitable starting materials of the formula II
- LG can denote a leaving group such as, for example, halogen, O-mesylate, O-tosylate, O-triflate or SO 2 Me and n, m, R 1 and R 2 have the abovementioned meanings, with compounds of the formula III,
- OR5 is a suitable protecting group for esters and V is an oxygen or sulfur atom and W, X and Y have the meanings mentioned above, under the influence of suitable inorganic and organic bases such as Na 2 CO 3 , Cs 2 CO 3 , K 2 CO 3 , NaH, DBU, DBN or potassium tert-butoxide in a suitable solvent such as dimethylformamide, dimethyl sulfoxide, toluene or tetrahydrofuran to give compounds of formula IV.
- suitable inorganic and organic bases such as Na 2 CO 3 , Cs 2 CO 3 , K 2 CO 3 , NaH, DBU, DBN or potassium tert-butoxide in a suitable solvent such as dimethylformamide, dimethyl sulfoxide, toluene or tetrahydrofuran to give compounds of formula IV.
- Mitsunobu conditions (O. Mitsunobu, Synthesis 1981, 1-28) to compounds of general formula IV, wherein V represents an oxygen atom.
- Mitsunobu conditions are also understood to mean the use of perfluorinated triphenylphosphine and perfluoro-azo-dicarboxylate variants, which became known only in later literature (S. Dandapani, D. P. Curran, Tetrahedron 2002, 58 (20), 3855-3864).
- the subsequent ester cleavage to compounds of the formula I is carried out according to literature-known methods.
- cyclopropanation of the acrylic ester can be carried out by literature-known methods, such as with trimethylsulfoxonium iodide in dimethyl sulfoxide and sodium hydride as base, to compounds of general formula XIII.
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Description
Claims
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2007250210A AU2007250210B2 (en) | 2006-05-11 | 2007-04-30 | 4,5-diphenyl-pyrimidinyl-oxy or -mercapto substituted carboxylic acids, method for the production and use thereof as medicaments |
MX2008014208A MX2008014208A (es) | 2006-05-11 | 2007-04-30 | Acidos carboxilicos sustituidos con 4,5-difenil-pirimidinil-oxi o -mercapto, metodo para la produccion y su uso como medicamentos. |
EP07724730.2A EP2024339B1 (de) | 2006-05-11 | 2007-04-30 | 4,5-diphenyl-pyrimidinyl-oxy oder -mercapto substituierte carbonsäuren, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
BRPI0711399-4A BRPI0711399A2 (pt) | 2006-05-11 | 2007-04-30 | ácidos carboxìlicos 4,5-difenil-primidinil-óxil ou -mercapto substituìdos, método para a produção e seu como medicamentos |
CA002651466A CA2651466A1 (en) | 2006-05-11 | 2007-04-30 | 4,5-diphenyl-pyrimidinyl-oxy or -mercapto substituted carboxylic acids, method for the production and use thereof as medicaments |
JP2009508190A JP2009536626A (ja) | 2006-05-11 | 2007-04-30 | 4,5−ジフェニル−ピリミジニル−オキシ又は−メルカプト置換カルボン酸類、それらの製造方法及び医薬品としての使用 |
IL195178A IL195178A0 (en) | 2006-05-11 | 2008-11-09 | 4,5-diphenyl-pyrimidinyl-oxy or-mercapto substituted carboxylic acids, method for the production and use thereof as medicaments |
US12/267,925 US7709494B2 (en) | 2006-05-11 | 2008-11-10 | 4,5-diphenyl-pyrimidinyl-oxy or -mercapto substituted carboxylic acids, method for the production and use thereof as medicaments |
NO20085064A NO20085064L (no) | 2006-05-11 | 2008-12-04 | 4,5-difenyl-pyrimidinyl-oksy eller -merkaptosubstituerte karboksylsyrer, fremgangsmate for deres fremstilling og anvendelse derav som medikamenter |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102006021872A DE102006021872B4 (de) | 2006-05-11 | 2006-05-11 | 4,5-Diphenyl-pyrimidinyl-oxy oder -mercapto substituierte Carbonsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
DE102006021872.8 | 2006-05-11 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/267,925 Continuation US7709494B2 (en) | 2006-05-11 | 2008-11-10 | 4,5-diphenyl-pyrimidinyl-oxy or -mercapto substituted carboxylic acids, method for the production and use thereof as medicaments |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2007131619A1 true WO2007131619A1 (de) | 2007-11-22 |
Family
ID=38283003
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2007/003803 WO2007131619A1 (de) | 2006-05-11 | 2007-04-30 | 4,5-diphenyl-pyrimidinyl-oxy oder -mercapto substituierte carbonsäuren, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
Country Status (16)
Country | Link |
---|---|
US (1) | US7709494B2 (de) |
EP (1) | EP2024339B1 (de) |
JP (1) | JP2009536626A (de) |
KR (1) | KR20090007413A (de) |
CN (1) | CN101421249A (de) |
AR (1) | AR060993A1 (de) |
AU (1) | AU2007250210B2 (de) |
BR (1) | BRPI0711399A2 (de) |
CA (1) | CA2651466A1 (de) |
DE (1) | DE102006021872B4 (de) |
IL (1) | IL195178A0 (de) |
MX (1) | MX2008014208A (de) |
MY (1) | MY148483A (de) |
NO (1) | NO20085064L (de) |
TW (1) | TW200815367A (de) |
WO (1) | WO2007131619A1 (de) |
Cited By (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7465804B2 (en) | 2005-05-20 | 2008-12-16 | Amgen Inc. | Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders |
WO2009021740A2 (de) | 2007-08-15 | 2009-02-19 | Sanofis-Aventis | Substituierte tetrahydronaphthaline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
US7572934B2 (en) | 2007-04-16 | 2009-08-11 | Amgen Inc. | Substituted biphenyl GPR40 modulators |
US7582803B2 (en) | 2005-09-14 | 2009-09-01 | Amgen Inc. | Conformationally constrained 3-(4-hydroxy-phenyl)-substituted-propanoic acids useful for treating metabolic disorders |
US7687526B2 (en) | 2006-09-07 | 2010-03-30 | Amgen Inc. | Benzo-fused compounds for use in treating metabolic disorders |
US7714008B2 (en) | 2006-09-07 | 2010-05-11 | Amgen Inc. | Heterocyclic GPR40 modulators |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
US8030354B2 (en) | 2007-10-10 | 2011-10-04 | Amgen Inc. | Substituted biphenyl GPR40 modulators |
WO2011157827A1 (de) | 2010-06-18 | 2011-12-22 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
WO2011161030A1 (de) | 2010-06-21 | 2011-12-29 | Sanofi | Heterocyclisch substituierte methoxyphenylderivate mit oxogruppe, verfahren zu ihrer herstellung und ihre verwendung als gpr40 rezeptor modulatoren |
WO2012004270A1 (de) | 2010-07-05 | 2012-01-12 | Sanofi | Spirocyclisch substituierte 1,3-propandioxidderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
WO2012004269A1 (de) | 2010-07-05 | 2012-01-12 | Sanofi | ( 2 -aryloxy -acetylamino) - phenyl - propionsäurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
WO2012010413A1 (de) | 2010-07-05 | 2012-01-26 | Sanofi | Aryloxy-alkylen-substituierte hydroxy-phenyl-hexinsäuren, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
WO2012030165A2 (ko) | 2010-08-31 | 2012-03-08 | 서울대학교산학협력단 | P P A R δ 활성물질의 태자재프로그래밍용도 |
WO2012120054A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2012120052A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
WO2012120055A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2012120053A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
US8450522B2 (en) | 2008-03-06 | 2013-05-28 | Amgen Inc. | Conformationally constrained carboxylic acid derivatives useful for treating metabolic disorders |
WO2014064215A1 (en) | 2012-10-24 | 2014-05-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | TPL2 KINASE INHIBITORS FOR PREVENTING OR TREATING DIABETES AND FOR PROMOTING β-CELL SURVIVAL |
US8748462B2 (en) | 2008-10-15 | 2014-06-10 | Amgen Inc. | Spirocyclic GPR40 modulators |
WO2016151018A1 (en) | 2015-03-24 | 2016-09-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method and pharmaceutical composition for use in the treatment of diabetes |
US9957219B2 (en) | 2013-12-04 | 2018-05-01 | Merck Sharp & Dohme Corp. | Antidiabetic bicyclic compounds |
US10059667B2 (en) | 2014-02-06 | 2018-08-28 | Merck Sharp & Dohme Corp. | Antidiabetic compounds |
US10710986B2 (en) | 2018-02-13 | 2020-07-14 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
US10774071B2 (en) | 2018-07-13 | 2020-09-15 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
US10899735B2 (en) | 2018-04-19 | 2021-01-26 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
US11236085B2 (en) | 2018-10-24 | 2022-02-01 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8193243B2 (en) | 2009-05-19 | 2012-06-05 | Neuroderm, Ltd. | Continuous administration of dopa decarboxylase inhibitors and compositions for same |
EP3159331A1 (de) | 2010-05-05 | 2017-04-26 | Infinity Pharmaceuticals, Inc. | Tetrazolone als fettsäuresynthasehemmer |
WO2011140296A1 (en) | 2010-05-05 | 2011-11-10 | Infinity Pharmaceuticals | Triazoles as inhibitors of fatty acid synthase |
CN103442693A (zh) * | 2010-11-15 | 2013-12-11 | 纽罗德姆有限公司 | L-多巴、多巴脱羧酶抑制剂、儿茶酚-o-甲基转移酶抑制剂及其组合物的连续施用 |
TR201903492T4 (tr) | 2012-06-05 | 2019-04-22 | Neuroderm Ltd | Apomorfin ve organik asitler içeren bileşimler ve bunların kullanım alanları. |
ES2836325T3 (es) | 2014-03-13 | 2021-06-24 | Neuroderm Ltd | Composiciones del inhibidor de la dopa descarboxilasa |
US10258585B2 (en) | 2014-03-13 | 2019-04-16 | Neuroderm, Ltd. | DOPA decarboxylase inhibitor compositions |
CN104193731B (zh) * | 2014-08-27 | 2017-03-15 | 广东东阳光药业有限公司 | 一种脲取代联苯类化合物及其组合物及用途 |
US11213502B1 (en) | 2020-11-17 | 2022-01-04 | Neuroderm, Ltd. | Method for treatment of parkinson's disease |
US11844754B2 (en) | 2020-11-17 | 2023-12-19 | Neuroderm, Ltd. | Methods for treatment of Parkinson's disease |
US11331293B1 (en) | 2020-11-17 | 2022-05-17 | Neuroderm, Ltd. | Method for treatment of Parkinson's disease |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5366982A (en) * | 1990-07-24 | 1994-11-22 | Rhone-Poulenc Rorer S.A. | Substituted bicyclic bis-aryl compounds exhibiting selective leukotriene B4 antagonist activity, their preparation and use in pharmaceutical compositions |
WO2004029204A2 (en) * | 2002-09-27 | 2004-04-08 | Merck & Co., Inc. | Substituted pyrimidines |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040259887A1 (en) * | 2003-06-18 | 2004-12-23 | Pfizer Inc | Cannabinoid receptor ligands and uses thereof |
-
2006
- 2006-05-11 DE DE102006021872A patent/DE102006021872B4/de not_active Withdrawn - After Issue
-
2007
- 2007-04-30 WO PCT/EP2007/003803 patent/WO2007131619A1/de active Application Filing
- 2007-04-30 JP JP2009508190A patent/JP2009536626A/ja not_active Ceased
- 2007-04-30 KR KR1020087027547A patent/KR20090007413A/ko active IP Right Grant
- 2007-04-30 AU AU2007250210A patent/AU2007250210B2/en not_active Ceased
- 2007-04-30 EP EP07724730.2A patent/EP2024339B1/de not_active Not-in-force
- 2007-04-30 MX MX2008014208A patent/MX2008014208A/es active IP Right Grant
- 2007-04-30 BR BRPI0711399-4A patent/BRPI0711399A2/pt not_active IP Right Cessation
- 2007-04-30 CA CA002651466A patent/CA2651466A1/en not_active Abandoned
- 2007-04-30 CN CNA2007800133694A patent/CN101421249A/zh active Pending
- 2007-04-30 MY MYPI20084471A patent/MY148483A/en unknown
- 2007-05-09 AR ARP070102011A patent/AR060993A1/es not_active Application Discontinuation
- 2007-05-09 TW TW096116360A patent/TW200815367A/zh unknown
-
2008
- 2008-11-09 IL IL195178A patent/IL195178A0/en unknown
- 2008-11-10 US US12/267,925 patent/US7709494B2/en not_active Expired - Fee Related
- 2008-12-04 NO NO20085064A patent/NO20085064L/no not_active Application Discontinuation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5366982A (en) * | 1990-07-24 | 1994-11-22 | Rhone-Poulenc Rorer S.A. | Substituted bicyclic bis-aryl compounds exhibiting selective leukotriene B4 antagonist activity, their preparation and use in pharmaceutical compositions |
WO2004029204A2 (en) * | 2002-09-27 | 2004-04-08 | Merck & Co., Inc. | Substituted pyrimidines |
Cited By (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7465804B2 (en) | 2005-05-20 | 2008-12-16 | Amgen Inc. | Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders |
US7582803B2 (en) | 2005-09-14 | 2009-09-01 | Amgen Inc. | Conformationally constrained 3-(4-hydroxy-phenyl)-substituted-propanoic acids useful for treating metabolic disorders |
US7687526B2 (en) | 2006-09-07 | 2010-03-30 | Amgen Inc. | Benzo-fused compounds for use in treating metabolic disorders |
US7714008B2 (en) | 2006-09-07 | 2010-05-11 | Amgen Inc. | Heterocyclic GPR40 modulators |
US8003648B2 (en) | 2006-09-07 | 2011-08-23 | Amgen Inc. | Heterocyclic GPR40 modulators |
US7572934B2 (en) | 2007-04-16 | 2009-08-11 | Amgen Inc. | Substituted biphenyl GPR40 modulators |
WO2009021740A2 (de) | 2007-08-15 | 2009-02-19 | Sanofis-Aventis | Substituierte tetrahydronaphthaline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
US8030354B2 (en) | 2007-10-10 | 2011-10-04 | Amgen Inc. | Substituted biphenyl GPR40 modulators |
US8450522B2 (en) | 2008-03-06 | 2013-05-28 | Amgen Inc. | Conformationally constrained carboxylic acid derivatives useful for treating metabolic disorders |
US8748462B2 (en) | 2008-10-15 | 2014-06-10 | Amgen Inc. | Spirocyclic GPR40 modulators |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
WO2011157827A1 (de) | 2010-06-18 | 2011-12-22 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
WO2011161030A1 (de) | 2010-06-21 | 2011-12-29 | Sanofi | Heterocyclisch substituierte methoxyphenylderivate mit oxogruppe, verfahren zu ihrer herstellung und ihre verwendung als gpr40 rezeptor modulatoren |
WO2012004270A1 (de) | 2010-07-05 | 2012-01-12 | Sanofi | Spirocyclisch substituierte 1,3-propandioxidderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
WO2012004269A1 (de) | 2010-07-05 | 2012-01-12 | Sanofi | ( 2 -aryloxy -acetylamino) - phenyl - propionsäurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
WO2012010413A1 (de) | 2010-07-05 | 2012-01-26 | Sanofi | Aryloxy-alkylen-substituierte hydroxy-phenyl-hexinsäuren, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
WO2012030165A2 (ko) | 2010-08-31 | 2012-03-08 | 서울대학교산학협력단 | P P A R δ 활성물질의 태자재프로그래밍용도 |
WO2012120054A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2012120052A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
WO2012120055A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2012120053A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2014064215A1 (en) | 2012-10-24 | 2014-05-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | TPL2 KINASE INHIBITORS FOR PREVENTING OR TREATING DIABETES AND FOR PROMOTING β-CELL SURVIVAL |
US9957219B2 (en) | 2013-12-04 | 2018-05-01 | Merck Sharp & Dohme Corp. | Antidiabetic bicyclic compounds |
US10059667B2 (en) | 2014-02-06 | 2018-08-28 | Merck Sharp & Dohme Corp. | Antidiabetic compounds |
WO2016151018A1 (en) | 2015-03-24 | 2016-09-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method and pharmaceutical composition for use in the treatment of diabetes |
US10710986B2 (en) | 2018-02-13 | 2020-07-14 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
US11555029B2 (en) | 2018-02-13 | 2023-01-17 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
US10899735B2 (en) | 2018-04-19 | 2021-01-26 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
US10774071B2 (en) | 2018-07-13 | 2020-09-15 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
US11236085B2 (en) | 2018-10-24 | 2022-02-01 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
Also Published As
Publication number | Publication date |
---|---|
BRPI0711399A2 (pt) | 2011-11-01 |
CA2651466A1 (en) | 2007-11-22 |
EP2024339B1 (de) | 2013-04-10 |
MY148483A (en) | 2013-04-30 |
EP2024339A1 (de) | 2009-02-18 |
AR060993A1 (es) | 2008-07-30 |
TW200815367A (en) | 2008-04-01 |
US20090149486A1 (en) | 2009-06-11 |
NO20085064L (no) | 2009-02-06 |
AU2007250210A1 (en) | 2007-11-22 |
IL195178A0 (en) | 2009-08-03 |
KR20090007413A (ko) | 2009-01-16 |
MX2008014208A (es) | 2008-11-14 |
CN101421249A (zh) | 2009-04-29 |
US7709494B2 (en) | 2010-05-04 |
DE102006021872B4 (de) | 2008-04-17 |
JP2009536626A (ja) | 2009-10-15 |
DE102006021872A1 (de) | 2007-12-27 |
AU2007250210B2 (en) | 2011-11-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE102006021872B4 (de) | 4,5-Diphenyl-pyrimidinyl-oxy oder -mercapto substituierte Carbonsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel | |
EP2024340B1 (de) | 4,5-diphenyl-pyrimidinyl-amino substituierte carbonsäuren, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel | |
EP2024338B1 (de) | 4,5-diphenyl-pyrimidinyl substituierte carbonsäuren, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel | |
EP2024347B1 (de) | Phenylamino-benzoxazol substituierte carbonsäuren, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel | |
EP2152711B1 (de) | 2 -heteroaryl- pyrrolo [3, 4-c]pyrrol- derivate und deren verwendung als scd inhibitoren | |
EP2328898B1 (de) | 2-heteroaryl-pyrrolo[3,4-c]pyrrol- derivate und ihre verwendung als scd inhibitoren | |
EP1940807B1 (de) | Carbamoylbenzotriazol-derivate als inhibitoren von lipasen und phospholipasen | |
EP2084173A1 (de) | Neue mit fluor substituierte 1,4-benzothiepin-1,1-dioxidderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung | |
WO2008058628A1 (de) | Neue mit benzylresten substituierte 1,4-benzothiepin-1,1-dioxidderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung | |
DE102005055726A1 (de) | Hydroxy-substituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung | |
EP2183222B1 (de) | Azoloarin derivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 07724730 Country of ref document: EP Kind code of ref document: A1 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 200780013369.4 Country of ref document: CN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2007724730 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2651466 Country of ref document: CA Ref document number: MX/a/2008/014208 Country of ref document: MX |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2009508190 Country of ref document: JP Ref document number: 2007250210 Country of ref document: AU Ref document number: 1020087027547 Country of ref document: KR |
|
WWE | Wipo information: entry into national phase |
Ref document number: 6119/CHENP/2008 Country of ref document: IN |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
ENP | Entry into the national phase |
Ref document number: 2007250210 Country of ref document: AU Date of ref document: 20070430 Kind code of ref document: A |
|
ENP | Entry into the national phase |
Ref document number: PI0711399 Country of ref document: BR Kind code of ref document: A2 Effective date: 20081112 |