WO2005083127A3 - Genetic polymorphisms associated with stroke, methods of detection and uses thereof - Google Patents

Genetic polymorphisms associated with stroke, methods of detection and uses thereof Download PDF

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Publication number
WO2005083127A3
WO2005083127A3 PCT/US2005/006075 US2005006075W WO2005083127A3 WO 2005083127 A3 WO2005083127 A3 WO 2005083127A3 US 2005006075 W US2005006075 W US 2005006075W WO 2005083127 A3 WO2005083127 A3 WO 2005083127A3
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WO
WIPO (PCT)
Prior art keywords
methods
detection
stroke
nucleic acid
genetic polymorphisms
Prior art date
Application number
PCT/US2005/006075
Other languages
French (fr)
Other versions
WO2005083127A2 (en
Inventor
May Luke
James Devlin
Michele Cargill
Original Assignee
Applera Corp
May Luke
James Devlin
Michele Cargill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applera Corp, May Luke, James Devlin, Michele Cargill filed Critical Applera Corp
Priority to JP2007501004A priority Critical patent/JP2009521205A/en
Priority to EP05733208A priority patent/EP1725684A2/en
Priority to CA002555259A priority patent/CA2555259A1/en
Publication of WO2005083127A2 publication Critical patent/WO2005083127A2/en
Publication of WO2005083127A3 publication Critical patent/WO2005083127A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention is based on the discovery of genetic polymorphisms that are associated with vascular diseases, particularly stroke. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
PCT/US2005/006075 2004-02-27 2005-02-25 Genetic polymorphisms associated with stroke, methods of detection and uses thereof WO2005083127A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2007501004A JP2009521205A (en) 2004-02-27 2005-02-25 Genetic polymorphisms associated with seizures, methods of detecting and using the same
EP05733208A EP1725684A2 (en) 2004-02-27 2005-02-25 Genetic polymorphisms associated with stroke, methods of detection and uses thereof
CA002555259A CA2555259A1 (en) 2004-02-27 2005-02-25 Genetic polymorphisms associated with stroke, methods of detection and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54809104P 2004-02-27 2004-02-27
US60/548,091 2004-02-27

Publications (2)

Publication Number Publication Date
WO2005083127A2 WO2005083127A2 (en) 2005-09-09
WO2005083127A3 true WO2005083127A3 (en) 2006-01-05

Family

ID=34910980

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/006075 WO2005083127A2 (en) 2004-02-27 2005-02-25 Genetic polymorphisms associated with stroke, methods of detection and uses thereof

Country Status (5)

Country Link
US (2) US20070059710A1 (en)
EP (1) EP1725684A2 (en)
JP (1) JP2009521205A (en)
CA (1) CA2555259A1 (en)
WO (1) WO2005083127A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12031161B2 (en) 2021-10-08 2024-07-09 University Of Massachusetts Targeting Nrip1 to alleviate metabolic disease

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US7666584B2 (en) * 2005-09-01 2010-02-23 Philadelphia Health & Education Coporation Identification of a pin specific gene and protein (PIN-1) useful as a diagnostic treatment for prostate cancer
US7799530B2 (en) 2005-09-23 2010-09-21 Celera Corporation Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof
EP2423334A3 (en) 2006-02-02 2012-04-18 The Board of Trustees of The Leland Stanford Junior University Non-invasive fetal genetic screening by digital analysis
US20080070792A1 (en) 2006-06-14 2008-03-20 Roland Stoughton Use of highly parallel snp genotyping for fetal diagnosis
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
US7695916B2 (en) * 2007-03-22 2010-04-13 Celera Corporation Genetic polymorphisms associated with coronary events and drug response, methods of detection and uses thereof
US20090221620A1 (en) * 2008-02-20 2009-09-03 Celera Corporation Gentic polymorphisms associated with stroke, methods of detection and uses thereof
CN102232116A (en) * 2008-10-03 2011-11-02 玛尔斯有限公司 Genetic test for liver copper accumulation in dogs and low copper pet diet
ES2344396B1 (en) * 2009-02-24 2011-06-24 Fina Biotech Slu GENETIC MARKERS OF THE RISK OF SUFFERING RESISTANCE.
US20110312503A1 (en) 2010-01-23 2011-12-22 Artemis Health, Inc. Methods of fetal abnormality detection
ES2387292B1 (en) * 2010-06-29 2013-10-30 Fundacio Institut De Recerca Hospital Universitari Vall D'hebron COMBINATION OF SNPS TO DETERMINE THE RISK OF SUFFERING A NEUROVASCULAR DISEASE
EP2750686B1 (en) 2011-06-17 2017-06-14 Shire Human Genetic Therapies, Inc. Polypeptide comprising frataxin and a c-terminal mitochondria penetrating peptide for use in the treatment of friedreich's ataxia
WO2013059740A1 (en) 2011-10-21 2013-04-25 Foundation Medicine, Inc. Novel alk and ntrk1 fusion molecules and uses thereof
GB201120989D0 (en) 2011-12-06 2012-01-18 Mars Inc Genetic test
AU2013337277B2 (en) 2012-11-05 2018-03-08 Foundation Medicine, Inc. Novel NTRK1 fusion molecules and uses thereof
AU2013337264B2 (en) 2012-11-05 2018-03-08 Foundation Medicine, Inc. Novel fusion molecules and uses thereof
WO2014113729A2 (en) 2013-01-18 2014-07-24 Foundation Mecicine, Inc. Methods of treating cholangiocarcinoma
EP3935581A4 (en) 2019-03-04 2022-11-30 Iocurrents, Inc. Data compression and communication using machine learning
CN110964802B (en) * 2019-11-11 2023-05-02 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） Application of ApoE gene in cerebral hemorrhage acute stage hematoma re-expansion and prognosis evaluation
CN115701998A (en) * 2020-06-25 2023-02-14 Ionis制药公司 Compounds and methods for reducing KCNT1 expression
EP4225904A2 (en) * 2020-10-09 2023-08-16 University of Massachusetts Targeting nrip1 to alleviate metabolic disease

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US5955266A (en) * 1996-04-01 1999-09-21 The Johns Hopkins University School Of Medicine Use of platelet polymorphism P1A2 to diagnose risk of thrombotic disease
WO2000071751A1 (en) * 1999-05-21 2000-11-30 Myriad Genetics, Inc. Diabetes gene
WO2001018250A2 (en) * 1999-09-10 2001-03-15 Whitehead Institute For Biomedical Research Single nucleotide polymorphisms in genes
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WO1998045477A2 (en) * 1997-04-04 1998-10-15 Eurona Medical Ab Methods for assessing cardiovascular status and compositions for use thereof
WO2000071751A1 (en) * 1999-05-21 2000-11-30 Myriad Genetics, Inc. Diabetes gene
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LEE BYUNG-CHEOL ET AL: "Susceptibility for ischemic stroke in Korean population is associated with polymorphisms of the interleukin-1 receptor antagonist and tumor necrosis factor-alpha genes, but not the interleukin-1beta gene.", NEUROSCIENCE LETTERS, vol. 357, no. 1, 26 February 2004 (2004-02-26), pages 33 - 36, XP002340558, ISSN: 0304-3940 *
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12031161B2 (en) 2021-10-08 2024-07-09 University Of Massachusetts Targeting Nrip1 to alleviate metabolic disease

Also Published As

Publication number Publication date
JP2009521205A (en) 2009-06-04
CA2555259A1 (en) 2005-09-09
WO2005083127A2 (en) 2005-09-09
US20090170111A1 (en) 2009-07-02
EP1725684A2 (en) 2006-11-29
US20070059710A1 (en) 2007-03-15

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