WO2005079920A1 - Equipo y procedimiento para la disminución y/o eliminación de arrugas en la piel - Google Patents
Equipo y procedimiento para la disminución y/o eliminación de arrugas en la piel Download PDFInfo
- Publication number
- WO2005079920A1 WO2005079920A1 PCT/ES2004/000046 ES2004000046W WO2005079920A1 WO 2005079920 A1 WO2005079920 A1 WO 2005079920A1 ES 2004000046 W ES2004000046 W ES 2004000046W WO 2005079920 A1 WO2005079920 A1 WO 2005079920A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- area
- treated
- skin
- equipment
- reduction
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/203—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser applying laser energy to the outside of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
- A61B2018/0047—Upper parts of the skin, e.g. skin peeling or treatment of wrinkles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B2018/1807—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using light other than laser radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B2018/2035—Beam shaping or redirecting; Optical components therefor
- A61B2018/20351—Scanning mechanisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B2018/2065—Multiwave; Wavelength mixing, e.g. using four or more wavelengths
- A61B2018/207—Multiwave; Wavelength mixing, e.g. using four or more wavelengths mixing two wavelengths
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/073—Radiation therapy using light using polarised light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
Definitions
- the skin is made up of three fundamental layers. The most external of them, the epidermis, presents a superficial layer (cornea) and an underlying layer that intervenes in the formation of new elements and in the determination of skin color.
- the dermis is made up of the papillary layer and the reticular layer that has a structural function and is made up of a series of cross-linked fibrils where collagen and elastin are found.
- the hypodermis the innermost layer of the skin, is located below the dermis and through it flow the blood vessels and nerves that go to the epidermis.
- the epidermis is made up of four layers: the basal layer, the spinous layer, the granular layer and the horny layer.
- the "stratum corneum”, the outermost layer of the skin, is the main barrier tissue that prevents loss of water from the body.
- ⁇ provides mechanical, bacterial and chemical protection.
- This layer is formed by a continuous matrix of organized lipid sheets inside which an extensive network of corneocytes is encapsulated.
- Corneocytes are plaque-shaped cells that play a crucial role in mechanically resistant barrier tissue. These cells are located inside the hydrophobic lipid sheets.
- a drawback of the prior art kits resides in the fact that they do not use polarized light in the post-treatment, which helps speed up the process of creating neo-collagen.
- the equipment of the invention is particularly, but not exclusively, intended for the reduction and / or elimination of skin wrinkles. With this equipment it is possible to modify and / or induce structural changes in the skin and / or subcutaneous tissue and it is particularly advantageous for the treatment of developmental, environmental, aging, post-surgical, post-traumatic conditions and certain aesthetic and pathological. It is a team that incorporates means for preparing the area of the skin to be treated and means for applying energy to said area to be treated.
- the equipment of the invention resides in that said means for preparing the area to be treated and said energy application means are all integrated in the same equipment.
- the means for preparing the area to be treated are formed by an ultrasound emission and / or dermabrasion device whose mission is to break the laminar organization of lipids and reduce the scattering of light that is radiated on the area to be treated, as will be detailed later, altering the ultrastructure of the corneal lipid layer.
- the energy application means comprise an emitting device capable of emitting individually or in combination various types of energy to the area to be treated.
- said ultrasound emission device is adapted to emit low frequency ultrasound to the area to be treated.
- said device comprises an ultrasound spatula provided with an extreme area adapted to be placed in contact with the area of the skin to be treated in order to clean the superficial layer of the epidermis, which has previously been impregnated by topical agents and / or appropriate drugs.
- Low frequency ultrasound application or dermabrasion allows to advantageously increase the permeability of the skin (low frequency sonophoresis). This facilitates the penetration of said topical agents and / or drugs.
- the energy emitted towards the area to be treated may be one of those listed below: - laser light and polarized light - intense pulsed light without polarization and polarized light; or - intense pulsed light with polarization and polarized light
- Polarization is a state of radiant energy, most noticeable in light, whose vibrations take on a definite shape or direction when subjected to special influences.
- Light can be polarized by reflection, or by transmission, through polarizing optical elements.
- Laser light monochromatic coherent polarized light
- the radiation response can be altered in different ways through physical factors such as the wavelength of the source used, or the increase in induced temperature.
- Conventional prior art equipment does not combine laser or intense pulsed light sources with a polarized or IP 2 L light source.
- the equipment of the present invention advantageously uses laser light or intense polarized pulsed light or intense non-polarized pulsed light with the advantage that it allows to maintain the temperature increase induced in the tissue for a longer period of time compared to the prior art equipment. Additionally, the use of polarized light has the advantage that it induces vasodilation of the area treated which produces an increase in the transport of active substances to the cell. Therefore, it is an advantage of the equipment object of the present invention the fact that, by using any of the combinations of light sources above, and by exposing the area to be treated of the skin with energy radiation Combined with at least one laser light source or intense polarized pulsed light or intense non-polarized pulsed light, significant structural changes will be induced in the collagen matrix and in the fibroblast phenotype.
- the polarized light source With the polarized light source, an increase in the amount of negatively charged sites on the fibroblast cell surface is obtained. This increase in negative surface charges can be considered as a biological effect of polarized light exerted on the cell membrane. This would produce an increase in the permeability of the membrane.
- the action of the equipment described on the area to be treated causes the release of growth factors from the stimulation of fibroblasts as a consequence of a proliferative response of the fibroblast. This effect cannot be achieved with non-polarized light sources used by conventional equipment.
- the aforementioned energy radiation is associated with the ultrasound radiation indicated above, as well as the application of topical agents and / or drugs. This combination allows to effectively improve the transcutaneous or transdermal delivery of such active substances by improving their penetration.
- the equipment of the invention may additionally be provided with a spraying device for the application of said topical agents and / or drugs on the area to be treated.
- the spraying device cooperates with said means for preparing the area to be treated.
- a scanner may also be arranged to cooperate with said emitting device. This scanner is adapted to automatically and evenly distribute the incident laser light beam over the area of the skin to be treated.
- the invention also relates to a procedure for the removal of wrinkles which can be carried out by means of the equipment of the invention described above.
- the procedure basically consists of impregnating the area of the skin to be treated with a topical agent and / or an appropriate drug, for example a cleansing substance to remove superficial dead cells from the epidermis.
- ultrasound is applied by means of the ultrasound spatula of the aforementioned equipment on the area to be treated impregnated with said topical agents and / or drugs.
- the area to be treated is then anesthetized and the ultrasound spatula is reapplied, but on the reverse side, so that the area to be treated absorbs said topical agents and / or drugs in a deeper and more immediate way by sonophoresis.
- the next step is to radiate laser light, unpolarized intense pulsed light, or polarized intense pulsed light.
- This will allow inducing an increase in temperature in the tissue for a determined period of time to cause significant structural changes in the collagen matrix and in the fibroblast phenotype, favoring vasodilation of the treated area, improving the transport of metabolites and active substances to the cells.
- the treated area will then be irradiated with polarized light to promote tissue recovery.
- Figure 1 is a perspective view illustrating an example of an apparatus according to the invention
- Figure 2 is an enlarged side elevation view of the ultrasonic spatula used in the embodiment of the equipment of the invention shown in Figure 1
- Figure 3 is an image obtained by optical microscopy by polarized light corresponding to an untreated area of the skin
- Figure 4 is an image obtained by optical microscopy by polarized light corresponding to a treated area of the skin
- Figure 5 is an image obtained by electron microscopy corresponding to dermis treated with the equipment of the invention
- Figure 6 is an image showing lysosomes going to the cell surface
- Figure 7 is an image showing the accumulation of substance around the fibroblast
- Figure 8 is an image showing large fibroblasts in the treated area
- Figures 9a and 9b are images obtained by electron
- FIG. 1 illustrates an example of a possible embodiment of an equipment for the elimination of skin wrinkles according to the invention which has been collectively designated by (1).
- the equipment (1) has the function of modifying and / or inducing structural changes in the patient's skin and / or subcutaneous tissue, with particular application in the treatment of developmental, environmental, aging, post-surgical, post-traumatic conditions and certain aesthetic and pathological conditions.
- Said equipment (1) comprises a display screen (2) to inform the operator of various operating parameters of the equipment (1) which is controlled by means of front buttons (3).
- Means are provided for the preparation of the area to be treated (4) and energy application means (5), both integrated in the equipment itself (1), as shown in said figure No. 1.
- Said means for the preparation of the area to be treated (4) comprise an ultrasound emission device, preferably a low frequency ultrasound emission device (15 KHz - 3 MHz) and / or a mechanical microdermabrasion device (0.01 - 3 bar) associated , by means of a cable (6), to an ultrasound spatula (7), which can be seen more clearly in Figure 5 of the drawings attached hereto.
- the ultrasound spatula (7) is provided with a handle (10) and an extreme application area (11).
- Said extreme application area (11) is adapted to be placed in contact with the area of the skin to be treated to clean the superficial layer of the epidermis, which has previously been impregnated by topical agents and / or drugs.
- the impregnation of the skin area to be treated is carried out through the aforementioned means for preparing the area to be treated (4) of the equipment (1).
- These means (4) also include nebulizers (12) that are connected, through respective ducts (13), to a compressor.
- the compressor (not shown) drives a pneumatic membrane and / or cylinder device that operates at a pressure in the order of 0.1-3 bar.
- a double diaphragm pump activated by an axis and a single motor can be used.
- the use of the ultrasound spatula (7) of the equipment (1) allows to effectively break the laminar organization of lipids in the superficial layer of the skin.
- the means for applying laser energy (5) are made up of an applicator (8) that is connected, through a fiber optic cable (9), to a device that emits the equipment (1).
- the applicator (8) transmits laser light, although it could also be, according to the invention, an applicator of intense pulsed light without polarization (IPL) or intense pulsed light polarized (IP 2 L) that would be formed by a flash (Xenon or Kripton) and a polarizing filter in case of IP 2 L and it would be connected to the equipment using electrical cables and cooling ducts (air or water).
- the broad spectrum polarized light application means consists of a broad spectrum lamp (17), a reflector, a polarizing filter, a bandpass filter, and a mechanical arm.
- One of said forms of energy is always a high power light source that can be either Laser, IPL or IP 2 L, according to the invention.
- the other form of energy can be polarized light.
- the values that define the energy emitted by the equipment (1) of the invention are, by way of example, the following: - Wavelength of laser light: 400-2000 nm. - Wavelength of intense pulsed light without polarization: 400-2000 nm. -Intense pulsed light wavelength with polarization: 400-2000 nm. - Wavelength of polarized light 400-3000 nm. - Ultrasonic frequency: 15 KHz-3 MHz.
- the equipment (1) also incorporates a scanner (14) adapted to be coupled to the handpiece (15) of the applicator (8) of the laser emitting device.
- the scanner (14) incorporates lenses (16) intended to direct the energy emitted towards the area of the skin to be treated.
- the face (A) of the extreme part (11) of the ultrasound spatula (7) of the equipment (1) is applied to said area of the skin emitting low frequency ultrasound.
- the combination of ultrasound emission with the application of the mentioned substance allows to effectively eliminate superficial dead cells from the patient's epidermis.
- the area to be treated is anesthetized and the ultrasound spatula (7) is reapplied but on the reverse side (B) of the end part (11). With this, the area to be treated absorbs the applied substance in a deeper and more immediate way by sonophoresis.
- Figures 3 and 4 illustrate the ultrastructural changes of the collagen network in the skin of a human being.
- Figures 9a and 9b the same microscope configurations have been used for the analysis. Comparing these figures, a clear increase in the polarization of the collagen network is observed due to structural changes in the organization of the fibrils.
- Fibroblasts are modified to a synthetic phase (figure n ° 5) in which an active synthesis of tropocollagen is observed.
- the cell expands and organelles such as endoplasmic reticulum and the Golgi apparatus expand.
- lysosomes are seen in the cell and multiple sites where tropocollagen is released are seen on the cell surface.
- the fibroblast is in the synthetic phase.
- the increase of the cell can also be observed by means of light microscopy (figure n ° 8).
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Optics & Photonics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Electromagnetism (AREA)
- Medical Informatics (AREA)
- Otolaryngology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgical Instruments (AREA)
- Radiation-Therapy Devices (AREA)
- Laser Surgery Devices (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002519553A CA2519553A1 (en) | 2004-02-20 | 2004-02-20 | Equipment for reducing and/or removing wrinkles in the skin and method thereof |
PCT/ES2004/000046 WO2005079920A1 (es) | 2004-02-20 | 2004-02-20 | Equipo y procedimiento para la disminución y/o eliminación de arrugas en la piel |
EP04713093A EP1716886A1 (en) | 2004-02-20 | 2004-02-20 | Equipment and method for reducing and eliminating wrinkles in the skin |
US10/544,723 US20060212029A1 (en) | 2004-02-20 | 2004-02-20 | Equipment and method for reducing and eliminating wrinkles in the skin |
JP2006553598A JP2007522854A (ja) | 2004-02-20 | 2004-02-20 | 皮膚の皺の低減及び/または除去機器並びに方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/ES2004/000046 WO2005079920A1 (es) | 2004-02-20 | 2004-02-20 | Equipo y procedimiento para la disminución y/o eliminación de arrugas en la piel |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2005079920A1 true WO2005079920A1 (es) | 2005-09-01 |
Family
ID=34878419
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/ES2004/000046 WO2005079920A1 (es) | 2004-02-20 | 2004-02-20 | Equipo y procedimiento para la disminución y/o eliminación de arrugas en la piel |
Country Status (5)
Country | Link |
---|---|
US (1) | US20060212029A1 (es) |
EP (1) | EP1716886A1 (es) |
JP (1) | JP2007522854A (es) |
CA (1) | CA2519553A1 (es) |
WO (1) | WO2005079920A1 (es) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009028278A (ja) * | 2007-07-26 | 2009-02-12 | Panasonic Electric Works Co Ltd | 光照射美容器具 |
JP2009539763A (ja) * | 2006-03-13 | 2009-11-19 | ザ プロクター アンド ギャンブル カンパニー | 哺乳類の皮膚の状態を調整する目的による、エネルギーと局所適用組成物の混用 |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6641591B1 (en) | 1999-08-26 | 2003-11-04 | John H. Shadduck | Instruments and techniques for controlled removal of epidermal layers |
US8048089B2 (en) | 2005-12-30 | 2011-11-01 | Edge Systems Corporation | Apparatus and methods for treating the skin |
US9566088B2 (en) | 2006-03-29 | 2017-02-14 | Edge Systems Llc | Devices, systems and methods for treating the skin |
WO2014151104A1 (en) | 2013-03-15 | 2014-09-25 | Edge Systems Llc | Devices, systems and methods for treating the skin |
US10172644B2 (en) | 2006-03-29 | 2019-01-08 | Edge Systems Llc | Devices, systems and methods for treating the skin |
KR101836310B1 (ko) | 2008-01-04 | 2018-03-08 | 엣지 시스템즈 엘엘씨 | 피부 처리 장치 및 방법 |
US9056193B2 (en) | 2008-01-29 | 2015-06-16 | Edge Systems Llc | Apparatus and method for treating the skin |
EP2451367B1 (en) | 2009-07-08 | 2020-01-22 | Edge Systems Corporation | Devices for treating the skin using time-release substances |
KR101178345B1 (ko) | 2010-04-30 | 2012-08-29 | 이하영 | 초음파를 이용한 광대 라인 교정 시스템 및 방법 |
US10238812B2 (en) | 2013-03-15 | 2019-03-26 | Edge Systems Llc | Skin treatment systems and methods using needles |
US10179229B2 (en) | 2014-12-23 | 2019-01-15 | Edge Systems Llc | Devices and methods for treating the skin using a porous member |
CA2971728A1 (en) | 2014-12-23 | 2016-06-30 | Edge Systems Llc | Devices for treating the skin using a rollerball |
JP2018527052A (ja) | 2015-07-08 | 2018-09-20 | エッジ システムズ エルエルシー | 育毛を促進するための装置、システムおよび方法 |
CN106109010B (zh) * | 2016-08-26 | 2019-02-05 | 柳州市工人医院 | 医用电离子点痣笔 |
BR102016027540A2 (pt) * | 2016-11-23 | 2018-06-12 | Lmg Lasers Comércio, Importação E Exportação Ltda | Aparelho para tratamento estético |
CN108187240B (zh) * | 2017-12-15 | 2022-11-25 | 重庆云帆医疗设备有限公司 | 一种祛皱治疗仪 |
CN110038230A (zh) * | 2019-05-14 | 2019-07-23 | 史灵芝 | 一种激光医疗机控制*** |
CN109999357A (zh) * | 2019-05-14 | 2019-07-12 | 史灵芝 | 皮肤治疗控制*** |
USD1016615S1 (en) | 2021-09-10 | 2024-03-05 | Hydrafacial Llc | Container for a skin treatment device |
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2004
- 2004-02-20 JP JP2006553598A patent/JP2007522854A/ja active Pending
- 2004-02-20 WO PCT/ES2004/000046 patent/WO2005079920A1/es not_active Application Discontinuation
- 2004-02-20 CA CA002519553A patent/CA2519553A1/en not_active Abandoned
- 2004-02-20 EP EP04713093A patent/EP1716886A1/en not_active Withdrawn
- 2004-02-20 US US10/544,723 patent/US20060212029A1/en not_active Abandoned
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US6595934B1 (en) * | 2000-01-19 | 2003-07-22 | Medtronic Xomed, Inc. | Methods of skin rejuvenation using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions |
WO2003001984A2 (en) | 2001-06-29 | 2003-01-09 | Light Bioscience, Inc. | Method and apparatus for the photomodulation of living cells |
WO2003015869A1 (en) * | 2001-08-20 | 2003-02-27 | Shanks Steven C | Improved hand-held laser device for skin treatment |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009539763A (ja) * | 2006-03-13 | 2009-11-19 | ザ プロクター アンド ギャンブル カンパニー | 哺乳類の皮膚の状態を調整する目的による、エネルギーと局所適用組成物の混用 |
JP2009028278A (ja) * | 2007-07-26 | 2009-02-12 | Panasonic Electric Works Co Ltd | 光照射美容器具 |
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Publication number | Publication date |
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US20060212029A1 (en) | 2006-09-21 |
EP1716886A1 (en) | 2006-11-02 |
JP2007522854A (ja) | 2007-08-16 |
CA2519553A1 (en) | 2005-09-01 |
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