WO2005033097A1 - P-glycoprotein inhibitor, method for preparing the same and pharmaceutical composition comprising the same - Google Patents
P-glycoprotein inhibitor, method for preparing the same and pharmaceutical composition comprising the same Download PDFInfo
- Publication number
- WO2005033097A1 WO2005033097A1 PCT/KR2004/002550 KR2004002550W WO2005033097A1 WO 2005033097 A1 WO2005033097 A1 WO 2005033097A1 KR 2004002550 W KR2004002550 W KR 2004002550W WO 2005033097 A1 WO2005033097 A1 WO 2005033097A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- dimethoxy
- phenyl
- ethyl
- dihydro
- isoquinolin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
- C04B35/632—Organic additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Definitions
- the present invention relates to an effective p-glycoprotein inhibitor and a pharmaceutically acceptable salt thereof, a method for preparing the same and a pharmaceutical composition containing the same as an active ingredient.
- anticancer agents e.g., vinca alkaloid, anthracycline, epipodophilotoxin, paclitaxel and docetaxel
- MDR multi-drug resistance
- P-glycoprotein inhibits intracellular accumulation of the administered anticancer agent by pumping the agent out of the cell
- WO 94/07858 WO 92/12132; WO 96/20180 and 98/17648; and WO 98/221112. Accordingly, the present inventors have endeavored to develop a p-glycoprotein inhibitor that is free from the above problems, and have found a novel compound which markedly enhances the bioavailability of anticancer agents by suppressing p-glycoprotein.
- Ri is aryl, heteroaryl, acrylaryl, acrylheteroaryl, heterocycloalkenyl, or carbocyclo, which is optionally substituted with one or more substituents selected from C 1-5 alkyl, hydroxy, C 1-5 alkoxy, halogen, trifluoromethyl, nitro and amino;
- R 2 , R 3 , R 4 , R 5 , R ⁇ , R 7 , Rs, R 9 , R 10 and R u are each independently hydrogen, hydroxy, halogen, nitro, C 1-5 alkyl or alkoxy, Re and R ⁇ being optionally fused together to form a 4 to 8-membered ring;
- m and n are each independently an integer ranging from 0 to 4; and
- X is CH 2 , O or S.
- the compound of formula (I) itself has no pharmacological activity, and, consequently, causes no side effects, while enhancing the bioavailability of anticancer agents by inhibiting the activity of p-glycoprotein.
- preferred R ⁇ is unsubstituted or substituted phenyl, pyridine, pyrazine, quinoline, isoquinoline, quinazoline, quinoxaline, pyrazole, imidazole, triazole, oxazole, thiazole, oxadiazole, thiadiazole, benzthiazole, benzoxazole, chromone, quinolone, cinnamic or quinoline acryl.
- Representative examples of the compound of formula (I) include: quinoline-3-carboxylic acid
- R l5 R 2 , R 3 , R 4 , R 5 , R ⁇ , R 7 , R 8 , R 9 , R 10 , Rn, m, n and X have the same meanings as defined in formula (I); R' and R" are each dependently OH, Cl or Br; and L is benzyl or tolyl.
- the compound of formula (I) may be prepared by (i) cyclizing a compound of formula (V) with a compound of formula (VI) in the presence of a base to obtain a compound of formula (IV); (ii) hydrogenating the compound of formula (IV) in the presence of a catalyst to obtain a compound of formula (II); and (iii) acylating the compound of formula (II) obtained in step (ii) with a compound of formula (III) in the presence of a base or a condensing agent.
- the base used in step (i) may be selected from the group consisting of pyridine, triethylamine and diisopropylethylamine.
- Step (i) may be conducted in a solvent such as methanol, ethanol, chloroform, dichloromethane, tetrahydrofuran, ethylether, hexane and toluene, and the compound of formula (VI) may be employed in an amount ranging from 1 to 2 equivalents based on 1 equivalent of the compound of formula (V).
- a solvent such as methanol, ethanol, chloroform, dichloromethane, tetrahydrofuran, ethylether, hexane and toluene
- Step (ii) may be conducted in a solvent, such as methanol, ethanol, chloroform, dichloromethane, tetrahydrofuran, ethylether, hexane and toluene, at a temperature ranging from 0 to 50°C; and the catalyst for step (ii) may be selected from the group consisting of palladium, platinium and zinc catalysts.
- the compound of formula (III) may be employed in an amount ranging from 1 to 1.5 equivalents relative to 1 equivalent of the compound of formula (II).
- the base of step (iii) may be used in an amount ranging from 1 to 2 equivalents per 1 equivalent of the compound of formula (II), while the condensing agent may be present in an amount ranging from 1 to 5 equivalents, preferably from 1 to 2 equivalents per 1 equivalent of the compound of formula (II).
- the base for step (iii) encompasses triethylamine, dipropylethylamine and pyridine; and the condensing agent in step (iii) may be selected from the group consisting of l-(3-dimethylaminopropyl)-3-ethylcarbodiimide, N,N'-dicyclohexylcarbodiimide, N,N'-diisopropylcarbodiimide and 1 -cyclohexyl-3-(2-(mo holinoethyl)carbodiimide) methyl-p-toluenesulfonate, preferably l-(3-dimethylaminopropyl)-3-ethylcarbodiimide.
- 4-(dimethylamino)pyridine may be added as a catalyst in an amount ranging from 0.05 to 0.3 equivalent based on 1 equivalent of the compound of formula (II).
- the acylation of the compound of formula (II) may be carried out in a solvent selected from the group consisting of dichloromethane, chloroform, N,N-dimethylformamide, tefrahydrofuran and 1,4-dioxane, preferably dichloromethane and chloroform, at a temperature ranging from -20°C to the boiling point of the solvent employed, preferably from 10 to 40°C.
- the compound of formula (V) may be prepared by reacting a compound of formula (VII) with toluenesulfonyl chloride or benzenesulfonyl chloride according to the method described in Bulletin of the Chemical Society of Japan Vol. 49(7), 1920-1923 (1976).
- toluenesulfonyl chloride or benzenesulfonyl chloride may be used in an amount ranging from 0.5 to 5 equivalents, preferably from 1 to 2 equivalents, per 1 equivalent of the compound of formula (VII), and the reaction may be conducted in a solvent selected from the group consisting of chloroform, tetrahydrofuran, ethanol, methanol and water, at a temperature ranging from -10 to 20°C, preferably from 0 to 5°C.
- the compound of formula (VI) may be prepared by reacting a compound of formula (X) with a compound of formula (XI) in the presence of a base, e.g., pyridine, triethylamine or diisopropylethylamine, to obtain a compound of formula (LX), hydrogenating the compound of formula (IX) in the presence of a catalyst to form a compound of formula (VIII), and reacting the compound of formula (VIII) with sodium nitrite and HCI ⁇ see Bulletin of the Chemical Society of Japan Vol. 49(7), 1920-1923 (1976)).
- a base e.g., pyridine, triethylamine or diisopropylethylamine
- reaction between the compound of formula (X) and the compound of formula (XI) may be carried out in a solvent selected from the group consisting of methanol, ethanol, chloroform, dichloromethane, tetrahydrofuran, ethylether, hexane and toluene, at a temperature ranging from 0 to 50°C.
- the catalyst suitable for this preparation is a metallic catalyst such as palladium, platinium or zinc catalyst, and the hydrogenation of the compound of formula (IX) may be conducted in a solvent such as methanol, ethanol, chloroform, dichloromethane, tetrahydrofuran, ethylether, hexane or toluene, at a temperature ranging from 0 to 50°C.
- the amount of sodium nitrite used in this preparation may range from 1 to 5 equivalents, preferably from 1 to 3 equivalents, per 1 equivalent of the compound of formula (VIII), while HCI may be employed in an amount ranging from 0.5 to 1 equivalent based on 1 equivalent of the compound of formula (VIII).
- the reaction converting the compound of formula (VIII) into the compound of formula (VI) may be conducted in a solvent such as ethanol, methanol or water, at a temperature ranging from -10 to 20°C, preferably from 0 to 5°C.
- a pharmaceutically acceptable salt of the p-glycoprotein inhibitor of formula (I) derived with an inorganic or organic acid may be conducted in a solvent such as ethanol, methanol or water, at a temperature ranging from -10 to 20°C, preferably from 0 to 5°C.
- a preferred inorganic or organic acid may be selected from the group consisting of hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, nitric acid, acetic acid, glycolic acid, lactic acid, pyrubic acid, malonic acid, succinic acid, glutamic acid, fumaric acid, malic acid, mandelic acid, tartaric acid, citric acid, ascorbic acid, palmitic acid, maleic acid, hydroxymaleic acid, benzoic acid, hydroxybenzoic acid, phenylacetic acid, cinnamic acid, salicylic acid, methanesulfonic acid, benzensulfonic acid and toluenesulfonic acid.
- the p-glycoprotein inhibitor of the present invention may be administered in combination with an anticancer agent which is not readily absorbed in the digestive tract due to the inhibitory action of p-glycoprotein.
- the present invention provides a composition comprising the p-glycoprotein inhibitor of formula (I) or a pharmaceutically acceptable salt thereof together with an anticancer agent, which is effective in: (a) improving or increasing the efficacy of the anticancer agent; (b) increasing or restoring the susceptibility of a tumor to the anticancer agent; or (c) reducing or reversing MDR of a tumor to the anticancer agent regardless of whether the MDR is acquired, induced or innate.
- the anticancer agent include taxan (e.g., paclitaxel and docetaxel), vinca alkaloid (e.g., vincristine, vinblastine and vinorelbine), anthracycline (e.g., daunomycin, daunorubicin, doxorubicin and aclarubicin), camptothecin (e.g., topotecan and irinotecan), podophyllotoxin (e.g., etoposide and VP16), mitoxantrone, actinomycin, colchicine, gramicidine D, and amsacrine.
- taxan e.g., paclitaxel and docetaxel
- vinca alkaloid e.g., vincristine, vinblastine and vinorelbine
- anthracycline e.g., daunomycin, daunorubicin, doxorubicin and aclarubicin
- the present invention provides a pharmaceutical composition
- a pharmaceutical composition comprising the compound of formula (I) or a pharmaceutically acceptable salt thereof as an effective ingredient together with pharmaceutically acceptable carriers, expients, or other additives, for the treatment of a mammal which suffers from a cancer: (a) to improve or increase the efficacy of an anticancer agent; (b) to increase or restore the susceptibility of a tumor to the anticancer agent; or (c) to reduce or reverse MDR of a tumor to the anticancer agent regardless of whether the MDR is acquired, induced or innate.
- the pharmaceutical composition of the present invention may be formulated for oral administration, or parenteral administration such as intramuscular, intravenous or transdermal administration.
- the pharmaceutical composition of the present invention may take the form of tablet, coated tablet, powder, rigid or soft gelatin capsule, solution, emulsion, microemulsion, or aqueous dispersion prepared in the conventional manner together with at least one pharmaceutically acceptable excipients, such as binding agents (e.g., pregelatinized maize starch, polyvinylpyrrolidone and hydroxypropyl methylcellulose); fillers (e.g., lactose, microcrystalline cellulose and calcium hydrogen phosphate); lubricants (e.g., magnesium stearate, talc and silica); disintegrants (e.g., sodium lauryl sulphate and sodium starch glycolate).
- binding agents e.g., pregelatinized maize starch, polyvinylpyrrolidone and hydroxypropyl methylcellulose
- fillers e.g., lactose, microcrystalline cellulose and calcium hydrogen phosphate
- lubricants e.g., magnesium stearate,
- Liquid preparations for oral administration may take the form of, for example, solutions, syrups or suspensions, or they may be presented as a dry product for constitution with water or other suitable vehicle before use.
- Such liquid preparations may be prepared by the conventional means together with at least one pharmaceutically acceptable additive such as a suspending agent (e.g., sorbitol syrup, a cellulose derivative and a hydrogenated edible fat); an emulsifying agent (e.g., lecithin and acacia); a non-aqueous vehicle (e.g., almond oil, oily ester, ethyl alcohol and fractionated vegetable oil); and a preservative (e.g., methyl or propyl-p-hydroxybenzoate and sorbic acid).
- a suspending agent e.g., sorbitol syrup, a cellulose derivative and a hydrogenated edible fat
- an emulsifying agent e.g., lecithin and acacia
- compositions of the present invention may be formulated for parenteral administration by bolus injection or continuous infusion. Formulations for injection may be presented in unit dosage form e.g., in ampoules or in multi-dose containers, with an added preservative.
- the pharmaceutical compositions may take the form of suspensions, solutions or emulsions in oily, aqueous or alcoholic vehicles, and contain surfactants, suspensions or emulsifiers, which may be selected from water, saline solution, glucose solution, sugar-like solution, alcohol, glycol, ether (e.g.
- a proposed daily dose of the compound of the present invention for administration to a human is about from 0.1 mg/kg to 100 mg/kg, more preferably about from 1 mg/kg to 20 mg/kg. It should be understood that the daily dose should be determined in light of various relevant factors including the condition to be treated, the severity of the patient's symptoms, the route of administration, or the physiological form of the anticancer agent; and, therefore, the dosage suggested above should not be construed to limit the scope of the invention in anyway.
- the following Examples are intended to further illustrate the present invention without limiting its scope.
- Example 1 Synthesis of quinoline-3 -carboxylic acid [2-(2-4-[2-(6,7-dimethoxy-3,4-dihydro-lH-isoquinolin-2-yl)-ethyl]-phenyl-2H-tetr azol-5-yl)-4,5-dimethoxy-phenyl]-amide
- Step 2 Preparation of 4,5-dimethoxy-2-nitro-p-toluenesulfonylhydrazone 6.90 g of p-toluenesulfonyl hydrazide was dissolved in 40 ml of ethanol, and 7.90 g of 6-nitroveratraldehyde dissolved in a small amount of ethanol was added thereto. The mixture was stirred at 80°C for 30 min, cooled to room temperature, and mixed with 100 ml of water. The solid formed therein was filtrated, washed with 100 ml of ethanol, and dried under a reduced pressure, to obtain 12.0 g of the title compound (yield 85%).
- Step 3 Preparation of 2-(2-4-[5-(4,5-dimethoxy-2-nitro-phenyl)-tetrazol-2-yl]-phenyl-ethyl)-6,7-dimetho xy- 1 ,2,3 ,4-tetrahydro-isoquinoline
- Step 5 Preparation of quinoline-3 -carbonyl chloride 10 g of 3 -quinoline carboxylic acid was mixed with 8.5 ml of thionyl chloride and 150 ml of toluene, and allowed to react at 100°C for 12 hours. The reaction mixture was condensed under a reduced pressure, to obtain a residue that gave 10 g of the title compound (yield 90%).
- Example 2 The procedure of Example 2 was repeated except for using 3 -isoquinoline carboxylic acid hydrate instead of quinaldic acid to obtain 0.12 g of the title compound (yield 62%).
- Example 2 The procedure of Example 2 was repeated except for using 8-quinoline carboxylic acid instead of quinaldic acid, to obtain 0.13 g of the title compound (yield 67%).
- 1H-NMR(CDC1 3 ) ⁇ : 13.69(s, IH), 8.87(d, IH), 8.77(q, IH), 8.37(s, IH), 8.24(d, IH), 8.06(d, IH), 8.00(d, 2H), 7.38(m, IH), 7.23(s, IH), 6.58(d, 2H), 4.03(d, 6H), 3.85(s, 6H), 3.65(s, 2H), 2.95(m, 2H), 2.81(m, 6H)
- Example 2 The procedure of Example 2 was repeated except for using 1 -isoquinoline carboxylic acid instead of quinaldic acid, to obtain 0.12 g of the title compound (yield 62%).
- 1H-NMR(CDC1 3 ) ⁇ : 12.76(s, IH), 9.76(d, IH), 8.91(s, IH), 8.73(d, IH), 8.37(d, 2H), 8.05(s, IH), 8.00(m, IH), 7.93(d, IH), 7.86(m, 2H), 7.47(d, 2H), 6.70(d, 2H), 4.17(d, 6H), 3.96(s, 6H), 3.80(s, 2H), 3.15(t, 2H), 2.94(m, 6H)
- Example 7 Synthesis of 4-methoxy-quinoline-2-carboxylic acid [2-(2- ⁇ 4-[2-(6,7-dimethoxy-3,4-dihydro-lH-isoquinolin-2-yl)-ethyl]- ⁇ henyl ⁇ -2H-tetr azol-5-yl)-4,5-dimethoxy-phenyl]-amide
- the procedure of Example 2 was repeated except for using 0.06 g of 4-methoxy-2-quinoline carboxylic acid instead of 0.05 g of quinaldic acid, to obtain 0.15 g of the title compound (yield 76%).
- Example 2 The procedure of Example 2 was repeated except for using 2-quinoxaline carboxylic acid instead of quinaldic acid, to obtain 0.14 g of the title compound (yield 73%).
- 1H-NMR(CDC1 3 ) ⁇ : 12.45(s, IH), 9.75(s, IH), 8.65(s, IH), 8.14(m, 4H),
- Example 9 Synthesis of pyridine-2-carboxylic acid [2-(2- ⁇ 4-[2-(6,7-dimethoxy-3,4-dihydro-lH-isoquinolin-2-yl)-ethyl]-phenyl ⁇ -2H-tetr azol-5-yl)-4,5-dimethoxy-phenyl]-amide
- Example 2 The procedure of Example 2 was repeated except for using 0.04 g of picolinic acid instead of 0.05 g of quinaldic acid, to obtain 0.13 g of the title compound (yield 73%).
- 1H-NMR(CDC1 3 ) ⁇ : 12.55(s, IH), 8.77(s, IH), 8.73(d, IH), 8.35(m, 3H), 7.94(t, 2H), 7.50(m, 3H), 6.58(d, 2H), 4.03(d, 6H), 3.85(d, 6H), 3.69(s, 2H), 3.05(t, 2H), 2.84(m, 6H)
- Example 2 The procedure of Example 2 was repeated except for using 0.04 g of nicotinic acid instead of 0.05 g of quinaldic acid, to obtain 0.12 g of the title compound (yield 67%).
- 1H-NMR(CDC1 3 ) ⁇ : 11.77(s, IH), 9.54(s, IH), 8.92(d, IH), 8.78(s, IH), 8.55(d, IH), 8.20(d, 2H), 7.93(s, IH), 7.60(m, 3H), 6.69(d, 2H), 4.14(d, 6H), 3.96(d, 6H), 3.79(s, 2H), 3.14(t, 2H), 2.95(m, 6H)
- Example 2 N-[2-(2- ⁇ 4-[2-(6,7-dimethoxy-3,4-dihydro-lH-isoquinolin-2-yl)-ethyl]- ⁇ henyl ⁇ -2H-t etrazol-5-yl)-4,5-dimethoxy-phenyl]-isonicotinamide
- the procedure of Example 2 was repeated except for using 0.04 g of isonicotinic acid instead of 0.05 g of quinaldic acid, to obtain 0.12 g of the title compound (yield 67%).
- Example 2 The procedure of Example 2 was repeated except for using 0.04 g of 2-pyrazine carboxylic acid instead of 0.05 g of quinaldic acid, to obtain 0.14 g of the title compound (yield 78%).
- 1H-NMR(CDC1 3 ) ⁇ : 12.47(s, IH), 9.56(d, IH), 8.83(d, IH), 8.73(s, IH), 8.70(m, IH), 8.30(d, 2H), 7.93(s, IH), 7.52(d, 2H), 6.59(d, 2H), 4.05(d, 6H), 3.86(d, 6H), 3.70(2H), 3.06(t, 2H), 2.85(m, 6H)
- Example 2 The procedure of Example 2 was repeated except for using benzoic acid instead of quinaldic acid, to obtain 0.15 g of the title compound (yield 84%).
- 1H-NMR(CDC1 3 ) ⁇ : 11.39(s, IH), 8.68(s, IH), 8.15(d, 2H), 8.08(d, 2H), 7.78(s, IH), 7.53(m, 3H), 7.42(d, 2H), 6.59(s, IH), 6.52(s, IH), 3.98(d, 6H), 3.82(s, 6H), 3.66(s, 2H), 2.98(t, 2H), 2.83(m, 6H)
- Example 2 The procedure of Example 2 was repeated except for using 0.06 g of 2-naphthoic acid instead of 0.05 g of quinaldic acid, to obtain 0.15 g of the title compound (yield 77%).
- 1H-NMR(CDC1 3 ) ⁇ : 11.65(s, IH), 8.79(s, IH), 8.69(s, IH), 8.23(d, IH),
- Example 2 The procedure of Example 2 was repeated except for using 2-fluorobenzoic acid instead of quinaldic acid, to obtain 0.12 g of the title compound (yield 66%).
- 1H-NMR(CDC1 3 ) ⁇ : 11.23(s, IH), 8.58(s, IH), 8.08(m, 3H), 7.84(s, IH), 7.52(m, IH), 7.44(d, 2H), 7.32(t, IH), 7.23(m, IH), 6.62(s, IH), 6.55(s, IH), 4.03(d, 6H), 3.85(s, 6H), 3.67(s, 2H), 3.01(t, 2H), 2.85(m, 6H)
- Example 2 The procedure of Example 2 was repeated except for using 3-fluorobenzoic acid instead of quinaldic acid, to obtain 0.02 g of the title compound (yield 11%).
- Example 2 The procedure of Example 2 was repeated except for using 4-fluorobenzoic acid instead of quinaldic acid, to obtain 0.13 g of the title compound (yield 70%).
- Example 2 The procedure of Example 2 was repeated except for using 0.06 g of 3,4-difluorobenzoic acid instead of 0.05 g of quinaldic acid, to obtain 0.12 g of the title compound (yield 63%).
- 1H-NMR(CDC1 3 ) ⁇ : 11.53(s, IH), 8.65(s, IH), 8.10(d, 2H), 7.98(m, IH), 7.90(m, IH), 7.84(s, IH), 7.49(d, 2H), 7.35(d, IH), 6.62(s, IH), 6.55(s, IH), 4.03(d, 6H), 3.85(s, 6H), 3.68(s, 2H), 3.04(t, 2H), 2.85(m, 6H)
- Example 2 The procedure of Example 2 was repeated except for using 3-thiophene carboxylic acid instead of quinaldic acid, to obtain 0.10 g of the title compound
- Example 2 [2-(2- ⁇ 4-[2-(6,7-dimethoxy-3,4-dihydro-lH-isoquinolin-2-yl)-ethyl]-phenyl ⁇ -2H-tetr azol-5-yl)-4,5-dimethoxy-phenyl]-amide
- the procedure of Example 2 was repeated except for using 0.04 g of 3-furoic acid instead of 0.05 g of quinaldic acid, to obtain 0.11 g of the title compound (yield 62%).
- Example 21 Synthesis of 4-oxo-4H-chromen-2-carboxylic acid [2-(2- ⁇ 4-[2-(6,7-dimethoxy-3,4-dihydro-lH-isoquinolin-2-yl)-ethyl]-phenyl ⁇ -2H-tetr azol-5-yl)-4,5-dimethoxy-phenyl]-amide
- the procedure of Example 2 was repeated except for using 0.07 g of chromone-2-carboxylic acid instead of 0.05 g of quinaldic acid, to obtain 0.16 g of the title compound (yield 80%).
- Example 22 Synthesis of 6-methyl-4-oxo-4H-chromene-2-carboxylic acid [2-(2- ⁇ 4-[2-(6,7-dimethoxy-3,4-dihydro-lH-isoquinolin-2-yl)-ethyl]-phenyl ⁇ -2H-t etrazol-5-yl)-4,5-dimethoxy-phenyl]-amide
- Example 2 The procedure of Example 2 was repeated except for using 0.08 g of 6-methylchromone-2-carboxylic acid instead of 0.05 g of quinaldic acid, to obtain 0.16 g of the title compound (yield 79%).
- 1H-NMR(CDC1 3 ) ⁇ : 12.49(s, IH), 8.62(s, IH), 8.14(d, 2H), 8.02(s, IH),
- Example 2 The procedure of Example 2 was repeated except for using 0.3 g of the compound obtained in step 4 of Example 1 and 0.19 g of 5-methoxychromone-2-carboxylic acid instead of 0.15 g of the compound of step 4 of Example 1 and 0.05 g of quinaldic acid, respectively, to obtain 0.23 g of the title compound (yield 55%).
- Example 2 The procedure of Example 2 was repeated except for using 0.3 g of the compound obtained in step 4 of Example 1 and 0.16 g of
- Example 25 Synthesis of 6-bromo-4-oxo-4H-chromene-2-carboxylic acid [2-(2- ⁇ 4-[2-(6,7-dimethoxy-3,4-dihydro-lH-isoquinolin-2-yl)-ethyl]-phenyl ⁇ -2H-t etrazol-5-yl)-4,5-dimethoxy-phenyl]-amide
- Example 2 The procedure of Example 2 was repeated except for using 0.25 g of the compound obtained in step 4 of Example 1 and 0.20 g of
- Example 2 [2-(2- ⁇ 4-[2-(6,7-dimethoxy-3,4-dihydro-lH-isoquinolin-2-yl)-ethyl]- ⁇ henyl ⁇ -2H-t etrazol-5-yl)-4,5-dimethoxy-phenyl]-amide
- the procedure of Example 2 was repeated except for using 0.3 g of the compound obtained in step 4 of Example 1 and 0.13 g of cinoline-4-carboxylic acid instead of 0.15 g of the compound of step 4 of Example 1 and 0.05 g of quinaldic acid, respectively, to obtain 0.16 g of the title compound (yield 41%).
- Example 27 Synthesis of 4-oxo-4H-chromene-3 -carboxylic acid [2-(2- ⁇ 4-[2-(6,7-dimethoxy-3,4-dihydro-lH-isoquinolin-2-yl)-ethyl]-phenyl ⁇ -2H-tetr azol-5-yl)-4,5-dimethoxy-phenyl]-amide
- Example 2 The procedure of Example 2 was repeated except for using 0.06 g of chromone-3 -carboxylic acid instead of 0.05 g of quinaldic acid, to obtain 0.08 g of the title compound (yield 40%).
- 1H-NMR(CDC1 3 ) ⁇ : 12.15(s, IH), 9.04(s, IH), 8.89(d, IH), 8.50(d, 2H),
- Step 1 Preparation of 4,5-difluoro-2-nitro-p-toluenesulfonehydrazone
- Step 4 Preparation of quinoline-3 -carboxylic acid [2-(2- ⁇ 4-[2-(6,7-dimethoxy-3 ,4-dihydro- 1 H-isoquinolin-2-yl)-ethyl]-phenyl ⁇ -2H-tetr azol-5-yl)-4,5-difluoro-phenyl]-amide
- Example 29 Synthesis of quinoline-3 -carboxylic acid [2-(2- ⁇ 4-[2-(6,7-dimethoxy-3,4-dihydro-lH-isoquinolin-2-yl)-ethylsulfanyl]-phenyl ⁇ -2H-tettazol-5-yl)-4,5-dimemoxy-phenyl]-amide
- Step 1 Preparation of l-(2-bromo-ethylsulfanyl)-4-nitro-benzene 6.94 ml of 1,2-dibromoethane was diluted with 100 ml of acetonitrile, mixed with 11.2 g of potassium carbonate and 5.0 g of 4-nitro-benzenethiol, and stirred at 80°C for 18 hours. After washing with 300 ml of distilled water and with 300 ml of aqueous NaCl, the resulting organic layer was dried over magnesium sulfate, filtrated, and distilled under a reduced pressure.
- Step 2 Preparation of 4-[2-(6,7-dimethoxy-3,4-dihydro-lH-isoquinolin-2-yl)-ethylsulfanyl]phenylamine
- Example 30 Synthesis of quinoline-3 -carboxylic acid
- Step 3 Preparation of 2-[2-(6,7-dimethoxy-3,4-dihydro-lH-isoquinolin-2-yl-ethyl)-2H-tetrazol-5-yl]-4,5-di methoxy-phenylamine
- Example 31 The procedure of Example 2 was repeated except for using 0.40 g of the compound obtained in Step 3 and 0.22 g of 3-quin ⁇ line carboxylic acid as starting materials to obtain 0.30 g of the title compound (yield 56%).
- 1H-NMR(CDC1 3 ) 9.30(s, IH), 8.80(s, IH), 8.20(m, IH), 8.15(d, IH), 7.90(t, 2H), 7.80(t, IH), 7.53(s, IH), 6.60(s, IH), 6.55(s, IH), 4.01(s, 2H), 3.80(s, 6H), 3.70(s, 6H), 3.7-3.5(m, 8H)
- Example 31 Synthesis of
- Example 2 N-[2-(2- ⁇ 4-[2-(6,7-dimethoxy-3,4-dihydro-lH-isoquinolin-2-yl)-ethyl]-phenyl ⁇ -2H-t etrazol-5-yl)-4,5-dimethoxy-phenyl]-3-phenyl-acrylamide
- the procedure of Example 2 was repeated except for using 0.15 g of the compound obtained in Step 4 of Example 1 and 0.05 g of trans-cinnamic acid as starting materials to obtain 0.11 g of the title compound (yield 59%).
- Example 2 N-[2-(2- ⁇ 4-[2-(6,7-dimethoxy-3,4-dihydro-lH-isoquinolin-2-yl)-ethyl]-phenyl ⁇ -2H-t etrazol-5-yl)-4,5-dimethoxy-phenyl]-3-quinolin-3-yl-acrylamide
- Example 2 was repeated except for using 0.22 g of the compound obtained in Step 4 of Example 1 and 0.10 g of the compound obtained in Step 1 as starting materials to obtain 0.18 g of the title compound (yield 61%).
- 1H-NMR(CDC1 3 ) 9.09(s, IH), 8.22(s, IH), 7.89-7.84(m, 2H), 7.77-7.71(m,
- Example 33 Synthesis of 4-oxo-4H-chromene-2-carboxylic acid (2- ⁇ 2-[4-(2- ⁇ [2-(3,4-dimethoxy-phenyl)-ethyl]-methyl-amino ⁇ -ethyl)-phenyl]-2H-tet razol-5-yl ⁇ -4,5-dimethoxy-phenyl)-amide
- the residue obtained thus was recrystallized from ethyl acetate to obtain 7.86 g of a nitro derivative.
- the nitro derivative was mixed with 200 ml of tefrahydrofuran and 200 ml of methanol, 0.5 g of Pd/C was added thereto, and the mixture was kept under 1 atmospheric hydrogen atmosphere for 18 hours.
- the reduction mixture was filtrated through a cellite pad under a reduced pressure, the pad was washed with methanol, the filtrate and wash solution were combined, and distilled under a reduced pressure to obtain a residue that gave 6.52 g of the title compound (yield 68%).
- Step 2 Preparation of 2- ⁇ 2-[4-(2- ⁇ [2-(3,4-dimethoxy- ⁇ henyl)-ethyl]-methyl-amino ⁇ -ethyl)- ⁇ henyl]-2H-tetr azol-5-yl ⁇ -4,5-dimethoxy-phenylamine
- Step 3 Preparation of 4-oxo-4H-chromene-2-carboxylic acid (2- ⁇ 2-[4-(2- ⁇ [2-(3,4-dimethoxy- ⁇ henyl)-ethyl]-methyl-amino ⁇ -ethyl)-phenyl]-2H-tet razol-5-yl ⁇ -4,5-dimethoxy-phenyl)-amide
- the procedure of Example 2 was repeated except for using 1 g of the compound obtained in Step 2 and 0.97 g of chromone-2-carboxylic acid as starting materials to obtain 0.99 g of the title compound (yield 75%).
- Example 34 Synthesis of quinoline-3-carboxylic acid [2-(2-4-[2-(6,7-dimethoxy-3,4-dihydro-lH-isoquinolin-2-yl)-ethyl]-phenyl-2H-tetraz ol-5-yl)-4,5-dimethoxy-phenyl]-amide methanesulfonate
- Example 2 1 g of the compound obtained in Example 1 was stirred with 70 ml of methanol for 30 min, and a mixture of 0.1 ml of methanesulfonic acid and 5 ml of methanol, was added dropwise thereto at 0°C. The mixture was heated to room temperature for 10 min, and stirred for 6 hours, which gave 0.95 g of the title compound (yield 83%).
- Example 35 Synthesis of 4-oxo-4H-chromene-2-carboxylic acid [2-(2- ⁇ 4-[2-(6,7-dimethoxy-3,4-dihydro-lH-isoquinoilin-2-yl)-ethyl]-phenyl ⁇ -2H-tet razol-5-yl)-4,5-dimethoxy-phenyl]-amide methanesulfonate
- Example 33 The procedure of Example 33 was repeated except for using 1.2 g of the compound obtained in Example 21 and 0.12 ml of methanesulfonic acid as starting materials to obtain 1.1 g of the title compound (yield 80%).
- Example 36 Synthesis of 4-oxo-4H-chromene-2-carboxylic acid [2-(2- ⁇ 4-[2-(6,7-dimethoxy-3,4-dihydro-lH-isoquinolin-2-yl)-ethyl]-phenyl ⁇ -2H-tetr azol-5-yl)-4,5-dimethoxy-phenyl]-amide hydrochloride
- Example 33 The procedure of Example 33 was repeated except for using 1.5 g of the compound obtained in Example 21 and 0.1 ml of hydrochloric acid as starting materials to obtain 1.4 g of the title compound (yield 89%).
- Example 1 Formulation of preparation for oral administration A tablet was prepared using the following ingredients, wherein the active ingredient was the compound of Example 21:
- Preparation Example 2 Formulation of preparation for oral administration.
- a hard gelatin capsule was prepared using the following ingredients, wherein the active ingredient was the compound of Example 21:
- capsules were also prepared by the same method using each of the inventive tetrazole derivatives of Example from 1 to 20 and from 22 to 36 as an active ingredient. At a case of the compound of Example 35, the amount used was 114 mg.
- injective preparations were also prepared by the same method using each of the inventive tetrazole derivatives of Example from 1 to 20 and from 22 to 36 as an active ingredient. At a case of the compound of Example 35, the amount used was 23 mg and HCI was not used.
- An injective preparation was prepared using the following ingredients, wherein the active ingredient was the compound of Example 21 :
- injective preparations were also prepared by the same method using each of the inventive tetrazole derivatives of Example from 1 to 20 and from 22 to 36 as an active ingredient. At a case of the compound of Example 35, the amount used was 23 mg.
- Test Example 1 Inhibition activity of inventive compound against p-glycoprotein
- MCF-7 cell and MCF-7/Dox cell which is MCF-7 expressing p-glycoprotein.
- the cells were subcultured in 5% FBS (fetal bovine serum)/RPMI1640 medium supplemented with glutamine 2 mmol, sodium bicarbonate 3.7 g/L and gentamicin 10 mg/L at 37°C in 5% CO 2 incubator under 100% humidity, and collected using a 0.25 % trypsin solution containing 3 mM 1,2-cyclohenxandiamine tetraacetic acid.
- the collected cells were plated on a 96 well flat-bottomed plate at a density of
- each well was treated with 100 ul of a test solution, alone or in combination with 50 nM each of the test compounds of Examples 1 to 30. After incubating for 72 hours, the culture medium was removed, each well was treated with 10% trichloroacetic acid for 1 hour to fix the cells, washed with water, and dried at room temperature.
- the paclitaxel has markedly higher cytotoxicity against MCF-7/Dx cells in case of treating in combination with the compounds of Examples than when treated alone, and it can be seen that the inventive compounds of formula (I) effectively suppress the activity of p-glycoprotein even at a low concentration of 50 nM.
- Test Example 2 In vivo absorption of orally administered paclitaxel
- Three of the former test groups were orally administered with 20 mg/kg body weight of paclitaxel (6 mg of paclitaxel/0.5 ml of cremophor EL + 0.5 ml of ethanol) and each of the compounds of Example 1, 21 and 22 (12 mg of the compounds of Examples/4 ml of 5% dextrose + 1.2 meg of methanesulfonic acid), and the control group was administered with a veheicle (4 mC of 5%-dextrose + 1.2 meg of methanesulfonic acid) and 20 mg of paclitaxel (composition: 6 mg of paclitaxel in 0.5 m# of cremorphor EL + 0.5 m ⁇ of ethanol).
- Blood samples were taken directly from the heart of each rat before and 1 , 2, 4, 6, 8 and 24 hours after the administration. Each of blood samples was centrifuged at 12,000 rpm to obtain a serum sample, 200 ⁇ l of which was mixed with 400 ⁇ l of acetonitrile (an internal standard) and the mixture was shaken to obtain an extract. The extract was centrifuged at 12,000 rpm, 4°C for 5 min to obtain a supernatant.
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Ceramic Engineering (AREA)
- Manufacturing & Machinery (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Structural Engineering (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials Engineering (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- External Artificial Organs (AREA)
Abstract
Description
Claims
Priority Applications (17)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BRPI0415053A BRPI0415053B8 (en) | 2003-10-07 | 2004-10-06 | p-glycoprotein inhibitor, method for preparing the same and pharmaceutical composition comprising the same |
CN2004800293562A CN1863795B (en) | 2003-10-07 | 2004-10-06 | P-glycoprotein inhibitor, method for preparing the same and pharmaceutical composition comprising the same |
DE602004026903T DE602004026903D1 (en) | 2003-10-07 | 2004-10-06 | P-GLYCOPROTEIN INHIBITOR, PROCESS TO WHICH HERSESIS CONTAINS |
US10/574,098 US7625926B2 (en) | 2003-10-07 | 2004-10-06 | P-glycoprotein inhibitor, method for preparing the same and pharmaceutical composition comprising the same |
EP04774778A EP1678162B1 (en) | 2003-10-07 | 2004-10-06 | P-glycoprotein inhibitor, method for preparing the same and pharmaceutical composition comprising the same |
JP2006532094A JP4481992B2 (en) | 2003-10-07 | 2004-10-06 | P-glycoprotein inhibitor, method for producing the same, and pharmaceutical composition containing the same |
NZ546257A NZ546257A (en) | 2003-10-07 | 2004-10-06 | P-glycoprotein inhibitor, method for preparing the same and pharmaceutical composition comprising the same |
PL04774778T PL1678162T3 (en) | 2003-10-07 | 2004-10-06 | P-glycoprotein inhibitor, method for preparing the same and pharmaceutical composition comprising the same |
DK04774778.7T DK1678162T3 (en) | 2003-10-07 | 2004-10-06 | Β-glycoprotein inhibitor, process for its preparation and pharmaceutical composition comprising it |
SI200431434T SI1678162T1 (en) | 2003-10-07 | 2004-10-06 | P-glycoprotein inhibitor, method for preparing the same and pharmaceutical composition comprising the same |
AU2004277475A AU2004277475B2 (en) | 2003-10-07 | 2004-10-06 | P-glycoprotein inhibitor, method for preparing the same and pharmaceutical composition comprising the same |
CA002541301A CA2541301C (en) | 2003-10-07 | 2004-10-06 | P-glycoprotein inhibitor, method for preparing the same and pharmaceutical composition comprising the same |
AT04774778T ATE466008T1 (en) | 2003-10-07 | 2004-10-06 | P-GLYCOPROTEIN INHIBITOR, METHOD FOR PRODUCING THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING SAME |
MXPA06003803A MXPA06003803A (en) | 2003-10-07 | 2004-10-06 | P-glycoprotein inhibitor, method for preparing the same and pharmaceutical composition comprising the same. |
IL174665A IL174665A (en) | 2003-10-07 | 2006-03-30 | Heterocyclic compounds which act as p-glycoprotein inhibitors, process for producing the same and pharmaceutical compositions containing the same |
NO20062019A NO336127B1 (en) | 2003-10-07 | 2006-05-05 | Β-glycoprotein inhibitor, processes for its preparation and pharmaceutical composition comprising the same |
HK07103870.2A HK1096399A1 (en) | 2003-10-07 | 2007-04-13 | P-glycoprotein inhibitor, method for preparing the same and pharmaceutical composition comprising the same p- |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020030069582A KR100557093B1 (en) | 2003-10-07 | 2003-10-07 | Tetrazole derivatives having inhibitory activity against multi-drug resistance and preparation thereof |
KR10-2003-0069582 | 2003-10-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2005033097A1 true WO2005033097A1 (en) | 2005-04-14 |
Family
ID=36500896
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/KR2004/002550 WO2005033097A1 (en) | 2003-10-07 | 2004-10-06 | P-glycoprotein inhibitor, method for preparing the same and pharmaceutical composition comprising the same |
Country Status (23)
Country | Link |
---|---|
US (1) | US7625926B2 (en) |
EP (1) | EP1678162B1 (en) |
JP (1) | JP4481992B2 (en) |
KR (1) | KR100557093B1 (en) |
CN (1) | CN1863795B (en) |
AT (1) | ATE466008T1 (en) |
AU (1) | AU2004277475B2 (en) |
BR (1) | BRPI0415053B8 (en) |
CA (1) | CA2541301C (en) |
DE (1) | DE602004026903D1 (en) |
DK (1) | DK1678162T3 (en) |
ES (1) | ES2342290T3 (en) |
HK (1) | HK1096399A1 (en) |
IL (1) | IL174665A (en) |
MX (1) | MXPA06003803A (en) |
NO (1) | NO336127B1 (en) |
NZ (1) | NZ546257A (en) |
PL (1) | PL1678162T3 (en) |
PT (1) | PT1678162E (en) |
RU (1) | RU2317985C1 (en) |
SI (1) | SI1678162T1 (en) |
WO (1) | WO2005033097A1 (en) |
ZA (1) | ZA200603538B (en) |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010520228A (en) * | 2007-03-01 | 2010-06-10 | ノバルティス アーゲー | PIM kinase inhibitor and method of use thereof |
JP2010522735A (en) * | 2007-03-28 | 2010-07-08 | ステリックス リミテッド | Tetrahydroisoquinolines as tumor growth inhibitors |
WO2011087316A2 (en) | 2010-01-15 | 2011-07-21 | 한미홀딩스 주식회사 | Method for preparing tetrazole methanesulfonic acid salts, and novel compound used in same |
US8592455B2 (en) | 2008-09-02 | 2013-11-26 | Novartis Ag | Kinase inhibitors and methods of their use |
CN103804352A (en) * | 2014-01-23 | 2014-05-21 | 中国药科大学 | Triazole phenethyl tetrahydro naphthalene compound and preparation method and application thereof |
WO2014092489A1 (en) | 2012-12-13 | 2014-06-19 | Hanmi Pharm. Co., Ltd. | Solid dispersion with improved solubility comprising tetrazole derivative as an active ingredient |
CN104327046A (en) * | 2014-10-14 | 2015-02-04 | 中国药科大学 | Triazole-N-ethyl tetrahydroisoquinoline compounds and preparing process and application thereof |
US8987457B2 (en) | 2012-05-21 | 2015-03-24 | Novartis Ag | Ring-substituted N-pyridinyl amides as kinase inhibitors |
WO2019200290A1 (en) * | 2018-04-13 | 2019-10-17 | Athenex Therapeutics Limited | Therapeutic combinations of orally administered paclitaxel and a p-gp inhibitor for the treatment of angiosarcoma |
WO2020124069A1 (en) * | 2018-12-14 | 2020-06-18 | Athenex HK Innovative Limited | Therapeutic combinations of orally administered docetaxel and a p-gp inhibitor for the treatment of cancer |
WO2020124070A1 (en) * | 2018-12-14 | 2020-06-18 | Athenex HK Innovative Limited | Therapeutic combinations of orally administered irinotecan and a p-gp inhibitor for the treatment of cancer |
WO2020168144A1 (en) | 2019-02-14 | 2020-08-20 | Teva Pharmaceuticals International Gmbh | Solid state forms of n-[2-(2-{4-[2-(6,7-dimethoxy-3,4-dihydro-2(lh)- isoquinolinyl)ethyl] phenyl }-2h-tetrazol-5-yl)-4,5-dimethoxyphenyl] -4- oxo-4h-chromene-2-carboxamide and of its mesylate salt |
WO2022011221A1 (en) | 2020-07-10 | 2022-01-13 | Teva Czech Industries S.R.O | Solid state forms of n-[2-(2-{4-[2-(6,7-dimethoxy-3,4-dihydro-2(1h)-isoquinolinyl)ethyl]phenyl}-2h-tetrazol-5-yl)-4,5-dimethoxyphenyl]-4-oxo-4h-chromene-2-carboxamide mesylate salt |
WO2022076663A1 (en) | 2020-10-07 | 2022-04-14 | Athenex, Inc. | Acetamido-phenyltetrazole derivatives and methods of using the same |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0700773D0 (en) * | 2007-01-15 | 2007-02-21 | Portela & Ca Sa | Drug therapies |
KR20150135110A (en) * | 2014-05-23 | 2015-12-02 | 한미정밀화학주식회사 | PHARMACEUTICAL COMPOSITION COMPRISING p-GLYCOPROTEIN INHIBITOR AND p-GLYCOPROTEIN SUBSTRATE DRUG |
JO3737B1 (en) * | 2015-07-21 | 2021-01-31 | Athenex Therapeutics Ltd | THERAPEUTIC COMBINATIONS OF ORALLY ADMINISTERED PACLITAXEL AND A P-gp INHIBITOR FOR THE TREATMENT OF CANCER |
TWI752750B (en) | 2015-09-30 | 2022-01-11 | 香港商慧源香港創新有限公司 | Oral taxane compositions and methods |
WO2020230037A1 (en) * | 2019-05-13 | 2020-11-19 | Dr. Reddy's Laboratories Limited | Alternate process for the preparation of encequidar |
WO2021044350A1 (en) * | 2019-09-04 | 2021-03-11 | Dr. Reddy’S Laboratories Limited | Solid forms of encequidar mesylate and processes thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992007844A1 (en) * | 1990-11-06 | 1992-05-14 | Pfizer Inc. | Quinazolines derivatives for enhancing antitumor activity |
JPH0543544A (en) * | 1991-08-09 | 1993-02-23 | Nisshin Flour Milling Co Ltd | Indole derivative and anticancer agent resistance overcomer containing the same as active ingredient |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE152443T1 (en) | 1992-07-10 | 1997-05-15 | Glaxo Lab Sa | ANILIDE DERIVATIVES |
GB9717576D0 (en) | 1997-08-19 | 1997-10-22 | Xenova Ltd | Pharmaceutical compounds |
AU2001234089B2 (en) * | 2000-02-15 | 2005-08-11 | Teijin Limited | Cancer remedy comprising anthranilic acid derivative as active ingredient |
DE60326341D1 (en) | 2002-05-14 | 2009-04-09 | Xenova Ltd | PROCESS FOR PREPARING ANTHRANILIC ACID DERIVATIVE HYDRATE |
KR100580743B1 (en) | 2003-10-08 | 2006-05-15 | 한미약품 주식회사 | A novel chromone derivative having multidrug resistance inhibitory activity or a pharmaceutically acceptable salt thereof and a preparing method thereof |
-
2003
- 2003-10-07 KR KR1020030069582A patent/KR100557093B1/en active IP Right Grant
-
2004
- 2004-10-06 PT PT04774778T patent/PT1678162E/en unknown
- 2004-10-06 DE DE602004026903T patent/DE602004026903D1/en active Active
- 2004-10-06 MX MXPA06003803A patent/MXPA06003803A/en active IP Right Grant
- 2004-10-06 EP EP04774778A patent/EP1678162B1/en active Active
- 2004-10-06 CA CA002541301A patent/CA2541301C/en active Active
- 2004-10-06 PL PL04774778T patent/PL1678162T3/en unknown
- 2004-10-06 SI SI200431434T patent/SI1678162T1/en unknown
- 2004-10-06 AU AU2004277475A patent/AU2004277475B2/en active Active
- 2004-10-06 WO PCT/KR2004/002550 patent/WO2005033097A1/en active IP Right Grant
- 2004-10-06 JP JP2006532094A patent/JP4481992B2/en active Active
- 2004-10-06 DK DK04774778.7T patent/DK1678162T3/en active
- 2004-10-06 CN CN2004800293562A patent/CN1863795B/en active Active
- 2004-10-06 AT AT04774778T patent/ATE466008T1/en active
- 2004-10-06 RU RU2006114427/04A patent/RU2317985C1/en active
- 2004-10-06 ES ES04774778T patent/ES2342290T3/en active Active
- 2004-10-06 NZ NZ546257A patent/NZ546257A/en unknown
- 2004-10-06 BR BRPI0415053A patent/BRPI0415053B8/en active IP Right Grant
- 2004-10-06 US US10/574,098 patent/US7625926B2/en active Active
-
2006
- 2006-03-30 IL IL174665A patent/IL174665A/en active IP Right Grant
- 2006-05-04 ZA ZA200603538A patent/ZA200603538B/en unknown
- 2006-05-05 NO NO20062019A patent/NO336127B1/en unknown
-
2007
- 2007-04-13 HK HK07103870.2A patent/HK1096399A1/en unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992007844A1 (en) * | 1990-11-06 | 1992-05-14 | Pfizer Inc. | Quinazolines derivatives for enhancing antitumor activity |
JPH0543544A (en) * | 1991-08-09 | 1993-02-23 | Nisshin Flour Milling Co Ltd | Indole derivative and anticancer agent resistance overcomer containing the same as active ingredient |
Non-Patent Citations (3)
Title |
---|
BORREL M.R. ET AL.: "Mobile ionophores are a novel class of P-glycoprotein inhibitors. The effect of ionophores on 4'-O-tetrahydropyranyladriamycin incorporation in K562 drug-resistant cells", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 233, no. 1, 1994, pages 125 - 133, XP008096606 * |
HAIT W. N. ET AL.: "Rational design and preclinical pharmacology of drugs for reversing multidrug resistance", BIOCHEMICAL PHARMACOLOGY, vol. 43, no. 1, 1992, pages 103 - 107, XP008096604 * |
WANG S. ET AL.: "Studies on quinazolinones as dual inhibitors of Pgp and MRP1 in multidrug resistance", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 12, no. 4, 2002, pages 571 - 574, XP009077496 * |
Cited By (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8822497B2 (en) | 2007-03-01 | 2014-09-02 | Novartis Ag | PIM kinase inhibitors and methods of their use |
JP2010520228A (en) * | 2007-03-01 | 2010-06-10 | ノバルティス アーゲー | PIM kinase inhibitor and method of use thereof |
JP2010522735A (en) * | 2007-03-28 | 2010-07-08 | ステリックス リミテッド | Tetrahydroisoquinolines as tumor growth inhibitors |
US8592455B2 (en) | 2008-09-02 | 2013-11-26 | Novartis Ag | Kinase inhibitors and methods of their use |
US9079889B2 (en) | 2008-09-02 | 2015-07-14 | Novartis Ag | Kinase inhibitors and methods of their use |
CN102812020A (en) * | 2010-01-15 | 2012-12-05 | 韩美科学株式会社 | Method for preparing tetrazole methanesulfonic acid salts, and novel compound used in same |
EP2524916A4 (en) * | 2010-01-15 | 2013-07-17 | Hanmi Science Co Ltd | Method for preparing tetrazole methanesulfonic acid salts, and novel compound used in same |
US8680277B2 (en) | 2010-01-15 | 2014-03-25 | Hanmi Science Co., Ltd | Method for preparing tetrazole methanesulfonic acid salts, and novel compound used in same |
EP2524916A2 (en) * | 2010-01-15 | 2012-11-21 | Hanmi Science Co., Ltd. | Method for preparing tetrazole methanesulfonic acid salts, and novel compound used in same |
US8940908B2 (en) | 2010-01-15 | 2015-01-27 | Hanmi Science Co., Ltd | Method for preparing tetrazole methanesulfonic acid salts, and novel compound used in same |
NO342589B1 (en) * | 2010-01-15 | 2018-06-18 | Hanmi Science Co Ltd | Process for the preparation of tetrazole-methanesulfonic acid salts and novel compound used therein |
CN102812020B (en) * | 2010-01-15 | 2015-03-18 | 韩美科学株式会社 | Method for preparing tetrazole methanesulfonic acid salts, and novel compound used in same |
WO2011087316A2 (en) | 2010-01-15 | 2011-07-21 | 한미홀딩스 주식회사 | Method for preparing tetrazole methanesulfonic acid salts, and novel compound used in same |
US8987457B2 (en) | 2012-05-21 | 2015-03-24 | Novartis Ag | Ring-substituted N-pyridinyl amides as kinase inhibitors |
US9173883B2 (en) | 2012-05-21 | 2015-11-03 | Novartis Ag | Ring-substituted N-pyridinyl amides as kinase inhibitors |
AU2013360544B2 (en) * | 2012-12-13 | 2017-05-11 | Hanmi Pharm. Co., Ltd. | Solid dispersion with improved solubility comprising tetrazole derivative as an active ingredient |
WO2014092489A1 (en) | 2012-12-13 | 2014-06-19 | Hanmi Pharm. Co., Ltd. | Solid dispersion with improved solubility comprising tetrazole derivative as an active ingredient |
EP2931720A4 (en) * | 2012-12-13 | 2016-06-29 | Hanmi Pharm Ind Co Ltd | Solid dispersion with improved solubility comprising tetrazole derivative as an active ingredient |
CN103804352A (en) * | 2014-01-23 | 2014-05-21 | 中国药科大学 | Triazole phenethyl tetrahydro naphthalene compound and preparation method and application thereof |
CN103804352B (en) * | 2014-01-23 | 2017-06-13 | 中国药科大学 | Triazole phenethyl tetrahydroisoquinolicompounds compounds and its preparation method and application |
CN104327046A (en) * | 2014-10-14 | 2015-02-04 | 中国药科大学 | Triazole-N-ethyl tetrahydroisoquinoline compounds and preparing process and application thereof |
WO2019200290A1 (en) * | 2018-04-13 | 2019-10-17 | Athenex Therapeutics Limited | Therapeutic combinations of orally administered paclitaxel and a p-gp inhibitor for the treatment of angiosarcoma |
US10849893B2 (en) | 2018-12-14 | 2020-12-01 | Athenex HK Innovative Limited | Therapeutic combinations of orally administered docetaxel and a P-gp inhibitor for the treatment of cancer |
WO2020124070A1 (en) * | 2018-12-14 | 2020-06-18 | Athenex HK Innovative Limited | Therapeutic combinations of orally administered irinotecan and a p-gp inhibitor for the treatment of cancer |
WO2020124069A1 (en) * | 2018-12-14 | 2020-06-18 | Athenex HK Innovative Limited | Therapeutic combinations of orally administered docetaxel and a p-gp inhibitor for the treatment of cancer |
CN113631166A (en) * | 2018-12-14 | 2021-11-09 | 慧源香港创新有限公司 | Therapeutic combination of orally administered irinotecan and a P-gp inhibitor for the treatment of cancer |
US11389442B2 (en) | 2018-12-14 | 2022-07-19 | Athenex HK Innovative Limited | Therapeutic combinations of orally administered docetaxel and a P-gp inhibitor for the treatment of cancer |
US11752139B2 (en) | 2018-12-14 | 2023-09-12 | Athenex HK Innovative Limited | Therapeutic combinations of orally administered irinotecan and a p-gp inhibitor for the treatment of cancer |
WO2020168144A1 (en) | 2019-02-14 | 2020-08-20 | Teva Pharmaceuticals International Gmbh | Solid state forms of n-[2-(2-{4-[2-(6,7-dimethoxy-3,4-dihydro-2(lh)- isoquinolinyl)ethyl] phenyl }-2h-tetrazol-5-yl)-4,5-dimethoxyphenyl] -4- oxo-4h-chromene-2-carboxamide and of its mesylate salt |
WO2022011221A1 (en) | 2020-07-10 | 2022-01-13 | Teva Czech Industries S.R.O | Solid state forms of n-[2-(2-{4-[2-(6,7-dimethoxy-3,4-dihydro-2(1h)-isoquinolinyl)ethyl]phenyl}-2h-tetrazol-5-yl)-4,5-dimethoxyphenyl]-4-oxo-4h-chromene-2-carboxamide mesylate salt |
WO2022076663A1 (en) | 2020-10-07 | 2022-04-14 | Athenex, Inc. | Acetamido-phenyltetrazole derivatives and methods of using the same |
US11739089B2 (en) | 2020-10-07 | 2023-08-29 | Athenex, Inc. | Acetamido-phenyltetrazole derivatives and methods of using the same |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US7625926B2 (en) | P-glycoprotein inhibitor, method for preparing the same and pharmaceutical composition comprising the same | |
SK3892001A3 (en) | Substituted 3-cyanoquinolines as protein tyrosine kinases inhibitors | |
EP2312950B1 (en) | Compounds as kinase inhibitors | |
CZ303899B6 (en) | Substituted 3-cyanoquinoline, process for its preparation and pharmaceutical composition containing thereof | |
KR102319264B1 (en) | Benzimidazole thiophene derivative compounds inducing selective degradation of PLK1 | |
WO2003000660A1 (en) | Quinoline derivative and quinazoline derivative inhibiting self-phosphorylation of hepatocytus proliferator receptor, and medicinal composition containing the same | |
JP2001502683A (en) | Anthranilic acid derivatives as multidrug resistance modulators | |
CZ299136B6 (en) | Substituted 3-cyanoquinolines | |
JP5229853B2 (en) | Novel bicyclic urea derivatives useful for the treatment of cancer and other diseases | |
EP3737677B1 (en) | Tetrahydroisoquinoline compounds | |
WO2009086731A1 (en) | New benzimidazole compounds | |
CA2404665A1 (en) | Novel compounds for enhancing chemotherapy | |
CN106117182B (en) | Quinazoline-N- phenethyl tetrahydroisoquinolicompounds compounds and its preparation method and application | |
EP3750893B1 (en) | Dioxazoline compound, preparation method therefor, and uses thereof | |
KR20200127223A (en) | Oxazino-quinazoline and oxazino-quinoline type compound, preparation method and use thereof | |
WO2023284159A1 (en) | Compound containing sulfamide structure, and preparation method therefor and application thereof, and pharmaceutical composition and application | |
CN104327046B (en) | Triazole N ethyl tetrahydroisoquinolicompounds compounds and its preparation method and application | |
CN106565599A (en) | 2-aminomethylpyridylnicotinamides and preparation method and application thereof | |
CN107529531A (en) | Triazole-N- phenethyl tetrahydroisoquinolicompounds compounds and its preparation method and application | |
WO2021254464A1 (en) | Substituted quinazoline compound, and preparation method therefor, pharmaceutical composition thereof, and use thereof | |
CN118146194A (en) | Novel quinoline compound containing 6-oxo-1-substituted phenyl-1, 6-dihydropyridazine-3-carboxamide and application thereof | |
KR20210131288A (en) | Benzimidazole thiophene derivative compounds inducing selective degradation of PLK1 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 200480029356.2 Country of ref document: CN |
|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 12006500648 Country of ref document: PH |
|
WWE | Wipo information: entry into national phase |
Ref document number: 174665 Country of ref document: IL Ref document number: 546257 Country of ref document: NZ |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2007072900 Country of ref document: US Ref document number: 10574098 Country of ref document: US |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2541301 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: PA/a/2006/003803 Country of ref document: MX |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2006532094 Country of ref document: JP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2327/DELNP/2006 Country of ref document: IN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2004774778 Country of ref document: EP Ref document number: 200603538 Country of ref document: ZA Ref document number: 2004277475 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2006114427 Country of ref document: RU |
|
ENP | Entry into the national phase |
Ref document number: 2004277475 Country of ref document: AU Date of ref document: 20041006 Kind code of ref document: A |
|
WWP | Wipo information: published in national office |
Ref document number: 2004277475 Country of ref document: AU |
|
WWP | Wipo information: published in national office |
Ref document number: 2004774778 Country of ref document: EP |
|
ENP | Entry into the national phase |
Ref document number: PI0415053 Country of ref document: BR |
|
WWP | Wipo information: published in national office |
Ref document number: 10574098 Country of ref document: US |
|
WWG | Wipo information: grant in national office |
Ref document number: 2004277475 Country of ref document: AU |