WO2004105704A2 - Emulsion base for skin care compositions - Google Patents
Emulsion base for skin care compositions Download PDFInfo
- Publication number
- WO2004105704A2 WO2004105704A2 PCT/US2004/017174 US2004017174W WO2004105704A2 WO 2004105704 A2 WO2004105704 A2 WO 2004105704A2 US 2004017174 W US2004017174 W US 2004017174W WO 2004105704 A2 WO2004105704 A2 WO 2004105704A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- emulsion base
- surfactants
- composition
- present
- total weight
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 162
- 239000000839 emulsion Substances 0.000 title claims abstract description 145
- 239000004094 surface-active agent Substances 0.000 claims abstract description 78
- 239000003795 chemical substances by application Substances 0.000 claims description 37
- 239000000516 sunscreening agent Substances 0.000 claims description 34
- 239000003755 preservative agent Substances 0.000 claims description 26
- 238000004078 waterproofing Methods 0.000 claims description 25
- 239000003974 emollient agent Substances 0.000 claims description 23
- 239000003906 humectant Substances 0.000 claims description 20
- 230000000475 sunscreen effect Effects 0.000 claims description 20
- 239000003085 diluting agent Substances 0.000 claims description 16
- 239000002562 thickening agent Substances 0.000 claims description 15
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 12
- 230000002335 preservative effect Effects 0.000 claims description 12
- 239000011734 sodium Substances 0.000 claims description 12
- 229910052708 sodium Inorganic materials 0.000 claims description 12
- -1 ceteareth-20 Chemical compound 0.000 claims description 11
- 238000000518 rheometry Methods 0.000 claims description 10
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 9
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 8
- 239000002738 chelating agent Substances 0.000 claims description 6
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 claims description 6
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims description 6
- 229940075529 glyceryl stearate Drugs 0.000 claims description 5
- 239000003002 pH adjusting agent Substances 0.000 claims description 5
- 150000002191 fatty alcohols Chemical class 0.000 claims description 4
- 239000004615 ingredient Substances 0.000 claims description 4
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 3
- NKEQOUMMGPBKMM-UHFFFAOYSA-N 2-hydroxy-2-[2-(2-hydroxy-3-octadecanoyloxypropoxy)-2-oxoethyl]butanedioic acid Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)COC(=O)CC(O)(C(O)=O)CC(O)=O NKEQOUMMGPBKMM-UHFFFAOYSA-N 0.000 claims description 3
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- CKQVRZJOMJRTOY-UHFFFAOYSA-N octadecanoic acid;propane-1,2,3-triol Chemical compound OCC(O)CO.CCCCCCCCCCCCCCCCCC(O)=O CKQVRZJOMJRTOY-UHFFFAOYSA-N 0.000 claims description 3
- 239000004147 Sorbitan trioleate Substances 0.000 claims description 2
- PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 claims description 2
- 239000002250 absorbent Substances 0.000 claims description 2
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- 239000000654 additive Substances 0.000 claims description 2
- 230000000996 additive effect Effects 0.000 claims description 2
- 150000001280 alpha hydroxy acids Chemical class 0.000 claims description 2
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- 230000000975 bioactive effect Effects 0.000 claims description 2
- 229940073669 ceteareth 20 Drugs 0.000 claims description 2
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- 230000003020 moisturizing effect Effects 0.000 claims description 2
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 claims description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 2
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- 229960004889 salicylic acid Drugs 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 235000019337 sorbitan trioleate Nutrition 0.000 claims description 2
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- 229930003231 vitamin Natural products 0.000 claims description 2
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- 229940088594 vitamin Drugs 0.000 claims description 2
- 239000004599 antimicrobial Substances 0.000 claims 1
- PYIDGJJWBIBVIA-UYTYNIKBSA-N lauryl glucoside Chemical compound CCCCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O PYIDGJJWBIBVIA-UYTYNIKBSA-N 0.000 claims 1
- 229940048848 lauryl glucoside Drugs 0.000 claims 1
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims 1
- 229940083542 sodium Drugs 0.000 claims 1
- NTYZDAJPNNBYED-UHFFFAOYSA-M sodium;2-(2-dodecanoyloxypropanoyloxy)propanoate Chemical compound [Na+].CCCCCCCCCCCC(=O)OC(C)C(=O)OC(C)C([O-])=O NTYZDAJPNNBYED-UHFFFAOYSA-M 0.000 claims 1
- AEEZIRBYGITPDN-UHFFFAOYSA-M sodium;dodecanoyl sulfate Chemical compound [Na+].CCCCCCCCCCCC(=O)OS([O-])(=O)=O AEEZIRBYGITPDN-UHFFFAOYSA-M 0.000 claims 1
- 150000003722 vitamin derivatives Chemical class 0.000 claims 1
- 239000003995 emulsifying agent Substances 0.000 abstract description 27
- 239000002537 cosmetic Substances 0.000 abstract description 10
- 229920001577 copolymer Polymers 0.000 description 22
- 238000009472 formulation Methods 0.000 description 17
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- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 9
- 239000007921 spray Substances 0.000 description 9
- WSDISUOETYTPRL-UHFFFAOYSA-N dmdm hydantoin Chemical compound CC1(C)N(CO)C(=O)N(CO)C1=O WSDISUOETYTPRL-UHFFFAOYSA-N 0.000 description 7
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 229940099451 3-iodo-2-propynylbutylcarbamate Drugs 0.000 description 5
- WYVVKGNFXHOCQV-UHFFFAOYSA-N 3-iodoprop-2-yn-1-yl butylcarbamate Chemical compound CCCCNC(=O)OCC#CI WYVVKGNFXHOCQV-UHFFFAOYSA-N 0.000 description 5
- 239000004322 Butylated hydroxytoluene Substances 0.000 description 5
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 5
- 239000013543 active substance Substances 0.000 description 5
- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 5
- 229940095259 butylated hydroxytoluene Drugs 0.000 description 5
- 150000002148 esters Chemical class 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 4
- USZDQUQLJBLEDN-UHFFFAOYSA-N 1-(1-tetradecoxypropan-2-yloxy)propan-2-yl propanoate Chemical compound CCCCCCCCCCCCCCOCC(C)OCC(C)OC(=O)CC USZDQUQLJBLEDN-UHFFFAOYSA-N 0.000 description 4
- TXBCBTDQIULDIA-UHFFFAOYSA-N 2-[[3-hydroxy-2,2-bis(hydroxymethyl)propoxy]methyl]-2-(hydroxymethyl)propane-1,3-diol Chemical compound OCC(CO)(CO)COCC(CO)(CO)CO TXBCBTDQIULDIA-UHFFFAOYSA-N 0.000 description 4
- DHVLDKHFGIVEIP-UHFFFAOYSA-N 2-bromo-2-(bromomethyl)pentanedinitrile Chemical compound BrCC(Br)(C#N)CCC#N DHVLDKHFGIVEIP-UHFFFAOYSA-N 0.000 description 4
- 229940100555 2-methyl-4-isothiazolin-3-one Drugs 0.000 description 4
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- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 description 4
- 229920002125 Sokalan® Polymers 0.000 description 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
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- 125000005250 alkyl acrylate group Chemical group 0.000 description 4
- 229960005193 avobenzone Drugs 0.000 description 4
- MWKFXSUHUHTGQN-UHFFFAOYSA-N decan-1-ol Chemical compound CCCCCCCCCCO MWKFXSUHUHTGQN-UHFFFAOYSA-N 0.000 description 4
- 239000004205 dimethyl polysiloxane Substances 0.000 description 4
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 4
- DLAHAXOYRFRPFQ-UHFFFAOYSA-N dodecyl benzoate Chemical compound CCCCCCCCCCCCOC(=O)C1=CC=CC=C1 DLAHAXOYRFRPFQ-UHFFFAOYSA-N 0.000 description 4
- 239000000499 gel Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- BEGLCMHJXHIJLR-UHFFFAOYSA-N methylisothiazolinone Chemical compound CN1SC=CC1=O BEGLCMHJXHIJLR-UHFFFAOYSA-N 0.000 description 4
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 4
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- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 4
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- PTPDZZWUOHQSLG-UHFFFAOYSA-N 2-octyldodecyl 2,2-dimethylpropanoate Chemical compound CCCCCCCCCCC(COC(=O)C(C)(C)C)CCCCCCCC PTPDZZWUOHQSLG-UHFFFAOYSA-N 0.000 description 3
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- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 description 3
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- DHNRXBZYEKSXIM-UHFFFAOYSA-N chloromethylisothiazolinone Chemical compound CN1SC(Cl)=CC1=O DHNRXBZYEKSXIM-UHFFFAOYSA-N 0.000 description 2
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- QUAMTGJKVDWJEQ-UHFFFAOYSA-N octabenzone Chemical compound OC1=CC(OCCCCCCCC)=CC=C1C(=O)C1=CC=CC=C1 QUAMTGJKVDWJEQ-UHFFFAOYSA-N 0.000 description 2
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- WSSJONWNBBTCMG-UHFFFAOYSA-N 2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester Chemical compound C1C(C)(C)CC(C)CC1OC(=O)C1=CC=CC=C1O WSSJONWNBBTCMG-UHFFFAOYSA-N 0.000 description 1
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- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 1
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- WYWZRNAHINYAEF-UHFFFAOYSA-N Padimate O Chemical compound CCCCC(CC)COC(=O)C1=CC=C(N(C)C)C=C1 WYWZRNAHINYAEF-UHFFFAOYSA-N 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 230000006750 UV protection Effects 0.000 description 1
- 229920006322 acrylamide copolymer Polymers 0.000 description 1
- BAPJBEWLBFYGME-UHFFFAOYSA-N acrylic acid methyl ester Natural products COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 1
- 229940069521 aloe extract Drugs 0.000 description 1
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- 230000004075 alteration Effects 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 229940111759 benzophenone-2 Drugs 0.000 description 1
- QRUDEWIWKLJBPS-UHFFFAOYSA-N benzotriazole Chemical compound C1=CC=C2N[N][N]C2=C1 QRUDEWIWKLJBPS-UHFFFAOYSA-N 0.000 description 1
- 239000012964 benzotriazole Substances 0.000 description 1
- WXNRYSGJLQFHBR-UHFFFAOYSA-N bis(2,4-dihydroxyphenyl)methanone Chemical compound OC1=CC(O)=CC=C1C(=O)C1=CC=C(O)C=C1O WXNRYSGJLQFHBR-UHFFFAOYSA-N 0.000 description 1
- SODJJEXAWOSSON-UHFFFAOYSA-N bis(2-hydroxy-4-methoxyphenyl)methanone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=C(OC)C=C1O SODJJEXAWOSSON-UHFFFAOYSA-N 0.000 description 1
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- 238000013461 design Methods 0.000 description 1
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- 230000009977 dual effect Effects 0.000 description 1
- CBZHHQOZZQEZNJ-UHFFFAOYSA-N ethyl 4-[bis(2-hydroxypropyl)amino]benzoate Chemical compound CCOC(=O)C1=CC=C(N(CC(C)O)CC(C)O)C=C1 CBZHHQOZZQEZNJ-UHFFFAOYSA-N 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000013020 final formulation Substances 0.000 description 1
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
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- 150000002433 hydrophilic molecules Chemical class 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 229940097413 isopropyl maleate Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229940102398 methyl anthranilate Drugs 0.000 description 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- VAMFXQBUQXONLZ-UHFFFAOYSA-N n-alpha-eicosene Natural products CCCCCCCCCCCCCCCCCCC=C VAMFXQBUQXONLZ-UHFFFAOYSA-N 0.000 description 1
- AFFLGGQVNFXPEV-UHFFFAOYSA-N n-decene Natural products CCCCCCCCC=C AFFLGGQVNFXPEV-UHFFFAOYSA-N 0.000 description 1
- 229920001206 natural gum Polymers 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- AEIJTFQOBWATKX-UHFFFAOYSA-N octane-1,2-diol Chemical compound CCCCCCC(O)CO AEIJTFQOBWATKX-UHFFFAOYSA-N 0.000 description 1
- FMJSMJQBSVNSBF-UHFFFAOYSA-N octocrylene Chemical group C=1C=CC=CC=1C(=C(C#N)C(=O)OCC(CC)CCCC)C1=CC=CC=C1 FMJSMJQBSVNSBF-UHFFFAOYSA-N 0.000 description 1
- 229960000601 octocrylene Drugs 0.000 description 1
- WCJLCOAEJIHPCW-UHFFFAOYSA-N octyl 2-hydroxybenzoate Chemical compound CCCCCCCCOC(=O)C1=CC=CC=C1O WCJLCOAEJIHPCW-UHFFFAOYSA-N 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- DXGLGDHPHMLXJC-UHFFFAOYSA-N oxybenzone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1 DXGLGDHPHMLXJC-UHFFFAOYSA-N 0.000 description 1
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- 239000002245 particle Substances 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001522 polyglycol ester Polymers 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000006254 rheological additive Substances 0.000 description 1
- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 description 1
- 235000019982 sodium hexametaphosphate Nutrition 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- CXVGEDCSTKKODG-UHFFFAOYSA-N sulisobenzone Chemical compound C1=C(S(O)(=O)=O)C(OC)=CC(O)=C1C(=O)C1=CC=CC=C1 CXVGEDCSTKKODG-UHFFFAOYSA-N 0.000 description 1
- 229960000368 sulisobenzone Drugs 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- UUJLHYCIMQOUKC-UHFFFAOYSA-N trimethyl-[oxo(trimethylsilylperoxy)silyl]peroxysilane Chemical compound C[Si](C)(C)OO[Si](=O)OO[Si](C)(C)C UUJLHYCIMQOUKC-UHFFFAOYSA-N 0.000 description 1
- 229920001567 vinyl ester resin Polymers 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/604—Alkylpolyglycosides; Derivatives thereof, e.g. esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Definitions
- the emulsion base itself can be formulated using ordinary, simple equipment and does not require major laboratory alteration or specialized equipment.
- LEXFEEL 350 which is dipentaerythritol hexa C 5 . 9 acid esters, is available from Inolex.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Cosmetics (AREA)
Abstract
The present invention is directed to an emulsion base for formulating cosmetic and dermatological compositions. The emulsion base has particular surfactant and/or emulsifier ratios such that a wide range of compositions with varying forms and additional components can be formulated without changing the ratio or amount of the primary and/or co surfactant/emulsifier in the emulsion base or the amount of the emulsion base in the final composition. The emulsion base can be used in a system of formulating cosmetic and dermatological compositions.
Description
EMULSION BASE FOR SKIN CARE COMPOSITIONS
BACKGROUND OF THE INVENTION
1. Field of the Invention The present invention relates to a stable and flexible emulsion base for use in formulating cosmetic and dermatological compositions. More particularly, the present invention relates to stable and flexible emulsion bases with surfactant/emulsifier ratios that allow formulation of a broad range of cosmetic and dermatological compositions, specifically suncare compositions.
2. Description of the Related Art
Cosmetic and dermatological compositions, including suncare compositions, are commercially available in various forms, such as lotions, sprays, creams, gels, milks, and the like, and are well known in the art. Formulators of such compositions generally start by combining various components together to develop, through trial and error, a composition that is stable and has the desired properties and form. These formulations typically involve a significant amount of time and expense with each attempt at a different combination of components and concentrations of those components.
Particularly, there are difficulty-formulating compositions that are stable and have properties desired for a specific type of composition. Compositions for different end uses require different basic properties, such as affinity of the composition for the skin and ability to be waterproof. The consumers of the compositions also demand certain properties, such as a luxurious, non-oily feeling on the skin. Consumers of suncare compositions, in particular, consider many factors when purchasing a suncare product, such as, the sun protection factor (SPF), how durable the product is after applying it over the skin, the shelf life of the product, and product form (i.e., lotions, gels, creams, and sprays). Another important and influential property of a suncare product considered by a consumer is how the product dispenses and how well the product spreads over the skin.
Typically, consumers want a suncare product that does not drip and/or run from the dispenser orifice, from the hand during application, or once applied to the skin. Balancing these properties in a composition that is also stable over time can require a multitude of costly trials before a suitable final formulation is obtained.
This difficulty is evident in the formulation of suncare compositions, especially those having UV absorbing or blocking active agents. Many of the suncare active agents, such as avobenzone, are known to pose particular problems in formulating stable compositions that also have desirable aesthetic and skin feel properties. Furthermore, the addition of waterproofing agents to compositions is often highly desirable. This is the case with suncare products where the consumer expects UV protection to last for considerable time periods despite the typical use of suncare products in outdoor activities that involve either water or perspiration. However, the addition of waterproofing agents is also known to produce difficulties in formulating stable compositions.
Attempts have been made to provide base formulations to which active agents, typical excipients, and emollients can be easily added to form cosmetic and dermatological compositions with decreased formulation and production expense. However, designing a base formulation that is stable, while providing the flexibility to adjust the base formulation and/or produce final compositions that have properties over wide ranges, is very difficult. A particular difficulty arises in balancing the types and concentrations of emulsifiers and surfactants in the base formulation needed to provide the desired properties in an oil-in-water (O/W) emulsion. Stability of such O/W emulsions can typically be enhanced by increasing the viscosity, which can be achieved by the addition of hydrophilic compounds such as certain emulsifiers and gums. However, finding the proper balance between greater stability and compositions that have unworkable thicknesses has heretofore not been satisfactorily achieved. A base formulation that also allows for ease and flexibility in the addition of waterproofing agents engenders further difficulty in design.
SUMMARY OF THE INVENTION
It is an object of the present invention to provide a flexible and stable emulsion base for formulating stable compositions including suncare, cosmetic, and dermatological compositions. It is another object of the present invention to provide a flexible and stable emulsion base that allows the formulation of a broad range of product forms without changing the ratio or amount of the primary surfactant/emulsifier and/or co-surfactant/emulsifier.
It is still another object of the present invention to provide such an emulsion base that can be formulated easily with a broad range of active agents, excipients, and emollients without changing the ratio or amount of the primary surfactant/emulsifier and/or co-surfactant/emulsifier.
It is still yet another object of the present invention to provide such an emulsion base that can be formulated easily with waterproofing agents without changing the ratio or amount of the primary surfactant/emulsifier and/or co-surfactant/emulsifier.
It is a further object of the present invention to provide a stable and flexible system using such an emulsion base.
It is still a further object of the present invention to provide such a system that allows changes in viscosity of the formulated composition without changes in the emulsion base and/or the amount of the emulsion base present in the total composition.
It is yet a further object of the present invention to provide a method of formulating a composition, including a suncare composition, having a stable and flexible emulsion base that does not change the ratio or amount of the primary surfactant/emulsifier and/or co-surfactant/emulsifier.
These and other foregoing objects and advantages, of the present invention are achieved, in brief summary, by an emulsion base that is stable and has the flexibility to allow the formulation of a broad range of product forms without changing the ratio or amount of the primary surfactant/emulsifier and/or co-surfactant/emulsifier. The present invention also provides a system of using an emulsion base to formulate a broad range of compositions without changing the ratio or amount of the primary
surfactant/emulsifier and/or co-surfactant/emulsifier. The present invention further provides suncare compositions formulated using such an emulsion base and/or system.
DETAILED DESCRIPTION OF THE INVENTION
It has been unexpectedly found that a flexible and stable system including an emulsion base, or base chassis, for use in the formulation of stable compositions, including cosmetic, dermatological, and/or suncare compositions, can be designed with particular ratios of one or more surfactants and/or emulsifiers.
An emulsion base of the present invention is a formulation having one or more primary surfactants/emulsifiers and one or more co- surfactants/emulsifiers. The one or more primary surfactants is a material that reduces interfacial tensions by having a dual functionality (hydrophobic portion and hydrophilic portion) allowing it to form an emulsion. Examples of suitable primary surfactants for use in an emulsion base of the present invention include, but are not limited to, CERALUTION® F, ceteareth-20, lauryi glucoside, sodium dicocoylethylenediamine PEG-15 sulfate, sodium iauroyl sarcosinates, or any combinations thereof. CERALUTION® F is available from Sasol and includes sodium dicocoylethylenediamine PEG-15 sulfate and sodium Iauroyl sulfate.
The one or more co-surfactants is a material that assists the primary surfactant by improving the packing at the primary surfactant interface and stabilizing the emulsion. The one or more co-surfactants preferably have an HLB value equal to or less than about 5. At this HLB value, a lamellar gel network is pre-built that when combined with a hydrophilic surfactant, that has a high HLB, renders the final emulsion. Examples of suitable co- surfactants for use in an emulsion base of the present invention include, but are not limited to, CERALUTION® H, BIOBASE® EP, glyceryl monostearate, solid fatty alcohols, sorbitan trioleate, fatty esters, glyceryl stearate, or any combinations thereof. CERALUTION® H is available from Sasol and includes behenyl alcohol, glyceryl stearate, glyceryl stearate citrate, and sodium dicocoylethylenediamine PEG-15 sulfate. BIOBASE®
EP is available from Tri-K and includes glycerin stearate, cetearyl alcohol, sodium Iauroyl lactylate, and lecithin.
It has been unexpectedly found that combining the one or more primary surfactants and the one or more co-surfactants in certain ratios provides a stable emulsion base, which can be used to formulate a broad range of product forms using a broad range of additional components, without changing the ratio of the primary surfactants and/or co-surfactants and/or changing the amount of the emulsion base in the total amount of the final formulated composition. As a result, a composition can be formulated without undue experimentation, reducing the time and expense associated with the formulation. In addition, it has been found that the emulsion base permits the inclusion of any known ester therein.
The ratio of the one or more primary surfactants to the one or more co-surfactants in an emulsion base of the present invention ranges from about 1 :3.75 to about 3.75:1 In one embodiment of the present invention, the ratio of the one or more primary surfactants to the one or more co- surfactants in an emulsion base of the present invention is from about 1 :2.67 to about 3:1. In another embodiment of the present invention, the ratio is about 2.13:1 of one or more primary surfactants to one or more co- surfactants. In yet another embodiment of the present invention, the ratio is about 3:1 of one or more primary surfactants to one or more co- surfactants. In still yet another embodiment of the present invention, the ratio is about 1 :2.67 of one or more primary surfactants to one or more co- surfactants. Once an acceptable ratio is chosen, different compositions can be formed having varying properties from an emulsion base of the present invention without changing the chosen ratio of one or more primary surfactants to one or more co-surfactants.
An emulsion base of the present invention itself may have the following components: diluent, thickener, emollient, humectant, preservative, solvent, or any combinations thereof. Preferably, an emulsion base of the present invention itself is formulated with one or more primary surfactants, one or more co-surfactants, one or more diluents, one or more
thickeners, one or more emollients, one or more humectants, and one or more preservatives.
One or more diluents may be present in an emulsion base of the present invention. Preferably, the diluent is water. The diluent may be present in an emulsion base of the present invention in an amount from about 39 wt.% to about 87 wt.%, preferably from about 42 wt.% to about 70 wt.%, most preferably about 44 wt.% to about 68 wt.% of the total weight of the emulsion base itself.
One or more emollients may be present in an emulsion base of the present invention. Examples of emollients that can be used in an emulsion base of the present invention include, but are not limited to, cocoglyceride, cyclomethicone, dimethicone, dicapryl maleate, caprylic/capric triglyceride, isopropyl myristate, octyl stearate, mineral oil, lanolin oil, coconut oil, cocoa butter, olive oil, avocado oil, aloe extracts, jojoba oil, castor oil, fatty acid such as oleic and stearic, fatty alcohol such as cetyl and hexadecyl, diisopropyl adipate, hydroxybenzoate esters, benzoic acid ester of C9-C15 alcohols, isononyl iso-nonanoate, alkane such as mineral oil, silicone such as dimethyl polysiloxane, ether such as polyoxypropylene butyl ether and polyoxypropylene cetyl ether, C12-C15 alkyl benzoate, octyldodecyl neopentanoate, PEG-7 methyl ether, di-PPG-3 myristyl ether adipate, LEXFEEL 350 (dipentaerythritol hexa C5.9 acid esters), LEXGARD O (caprylyl glycol) that is available from Inolex, CRODAMOL PMP (PPG-2 myristyl ether propionate) that is available from Croda or any combinations thereof. Preferably, the emollient of an emulsion base of the present invention is Cι2-C1 alkyl benzoate, PEG-7 methyl ether, or any combinations thereof.
It is noted that the emulsion base can include sunscreen boosters and/or photostabilizers. For example, PEG-7 methyl ether acts as a SPF booster. LEXOGARD O acts as both a sunscreen photostabilizer and booster. The emollient may be present in an emulsion base of the present invention in an amount about 14 wt.% to about 45 wt.%, preferably about 18 wt.% to about 33 wt.%, and more preferably about 21 wt.% to about 28 wt.% of the total weight of the emulsion base itself.
One or more thickeners may be present in an emulsion base of the present invention. Examples of thickeners that can be used in an emulsion base of the present invention include, but are not limited to, acetamide MEA, acrylamide copolymer, acrylates copolymer, acrylates/steareth-20 methacrylate copolymer, acrylates/beheneth-25 methacrylate copolymer, PEG-150/decyl alcohol/SMDI copolymer, PVP, PVM/MA decadiene crosspolymer, carbomer, PEG crosspolymer, acrylates/palmeth-25 acrylates copolymer, polysaccharide, polyether-1 , sodium magnesium silicate, bentonite, trihydroxystearin, hydroxy stearate, aluminum- magnesium hydroxide stearate, acacia gum, xanthan gum, or any combinations thereof. Preferably, the thickeners of an emulsion base of the present invention are Acacia gum, xanthan gum, or any combinations thereof.
The one or more thickeners may be present in an emulsion base of the present invention in an amount from about 0.05 wt.% to about 3 wt.%, preferably from about 0.1 wt.% to about 2 wt.%, and more preferably about 0.15 wt.% to about 1.7 wt.% of the total weight of the emulsion base itself.
One or more humectants may be present in an emulsion base of the present invention. Examples of humectants that can be used in an emulsion base of the present invention include, but are not limited to, glycerin, propylene glycol, butylene glycol, sorbitol, PEG-4, or any combinations thereof. Preferably, the humectant of an emulsion base of the present invention is glycerin.
The one or more humectants may be present in an emulsion base of the present invention in an amount about 3 wt.% to about 11 wt.%, preferably about 4 wt.% to about 8 wt.%, most preferably about 5 wt.% to about 7 wt.%, of the total weight of the emulsion base itself.
One or more preservatives may be present in an emulsion base of the present invention. The one or more preservatives protect the emulsion base and the compositions formulated from the emulsion base from microbial contamination and/or oxidation. As such, the preservative can include an antioxidant. Examples of preservatives that can be used in an emulsion base of the present invention include, but are not limited to,
diazolidinyl urea, iodopropynyl butylcarbamate, DMDM hydantoin, iodipropynyl butylcarbamate, chloromethylisotiazolinone, methylisothiazolinone, methyldibromo glutaronitrile, vitamin E and its derivatives including vitamin E acetate, vitamin C, butylated hydroxytoluene (BHT), butylparaben, ethylparaben, methylparaben, propylparaben, phenoxyethanol, or any combinations thereof. In one embodiment, the preservative is a combination of DMDM hydantoin and iodopropynyl butylcarbamate sold under the tradename GLYDANT PLUS® by Lonza. In another embodiment, the preservative is a combination of methyldibromo glutaronitrile, methylchloroisothiazolinone, methylisothiazolinone, and phenoxyethanol sold under the tradename EUXYL® K727 by Schulke and Mayr GMBH & Co. KG.
The one or more preservatives may be present in an emulsion base of the present invention in an amount about 0.1 wt.% to about 2 wt.%, preferably about 0.5 wt.% to about 1.5 wt.%, most preferably about 1 wt.% to about 1.3 wt.%, of the total weight of the emulsion base itself.
A preferred example of the emulsion base is set forth in Table 1.
Table 1 : Emulsion Base Example A
CERALUTION® F is available from Sasol and includes sodium dicocoylethylenediamine PEG-15 sulfate and sodium Iauroyl sulfate.
CERALUTION® H is available from Sasol and includes behenyl alcohol, glyceryl stearate, glyceryl stearate citrate, and sodium dicocoylethylenediamine PEG-15 sulfate.
BIOBASE® EP is available from Tri-K and includes glycerin stearate, cetearyl alcohol, sodium Iauroyl lactylate, and lecithin.
GLYDANT® Plus is available from Lonza and includes DMDM hydantoin and iodopropynyl butylcarbamate.
Another example of an emulsion base of the present invention is set forth in Table 2.
Table 2: Emulsion Base Example B
EUXYL K727 is available from Schulke and Mayr GMBH & Co. KG and includes methyldibromo glutaronitrile, methylchloroisothiazolinone, methylisothiazolinone, and phenoxyethanol.
Yet another example of an emulsion base of the present invention is set forth in Table 3.
Table 3: Emulsion Base Example C
Still yet another example of an emulsion base of the present invention is set forth in Table 4.
Table 4: Emulsion Base Example D
PEMULEN® TR-2 is available from Noveon and includes acrylates/Cιo-3o alkyl acrylate crosspolymer.
Testing has shown these examples of the emulsion base of the present invention to be stable at higher temperatures, e.g. 40°C for three months and 50°C for one month.
These examples of the stable emulsion base of the present invention provide superb flexibility in the ability to formulate a wide range of product forms including a wide range of additional components. The emulsion base provides a stable platform for formulating compositions that have desirable properties, including, for example, a luxurious skin feel and improved skin affinity.
The use of the primary and co-surfactant in the specified ratios provides a system that allows the formulator to simply add additional components to a sample of the emulsion base to produce a stable composition. There are no specific requirements for the additional
components that may be selected from the typical components used to formulate cosmetic and dermatological compositions. Examples of additional components that may be formulated with an emulsion base of the present invention include, but are not limited to, sunscreen agent; secondary surfactant; secondary emollient; skin-feel additive; moisturizing agent; film former/waterproofing agent; bio-active (functional) ingredient; pharmaceutical ingredient; pH adjuster/chelating agent; secondary preservative; antimicrobial; secondary humectant; rheology modifying agent; one or more fragrances; colorants; plant extracts; absorbents; salicylic acid; alpha and beta hydroxy acids; vitamins including vitamins A, C, and E and their derivatives; or any combinations thereof.
The formulator can easily change compositions by simply changing the type and amount of additional components. Further, the formulator can easily change the emulsion base so long as the emulsion base retains the desired ratio of primary surfactant to co-surfactant. The formulator can use the same emulsion base to formulate a wide range of compositions having various viscosities, SPF values, levels of active agent, levels of waterproofing agent, or levels of other desired additional components. Additional aqueous components can be added to the emulsion base by simple mixing. Additional oil components can be added to the emulsion base with the addition of energy and/or high sheer. This is done to ensure desired particle sizes. Additional components can be easily added to the emulsion base after the emulsion base has been formulated. Alternatively, additional components can be added to the oil phase of the emulsion base and to the aqueous phase of the emulsion base prior to combination.
The formulation of various compositions having different properties can be done with or without changing the amount of the emulsion base present in the final composition. Thus, a static amount of an emulsion base of the present invention can be used to formulate compositions that have various properties. Typically, the amount of an emulsion base of the present invention that can be used to formulate compositions is about 10 wt.% to about 25 wt.% of the total weight of the composition formulated therewith. Preferably, the amount of an emulsion base of the present
invention is about 15 wt.% to about 25 wt.% of the total weight of the formulated composition. More preferably, the amount of an emulsion base of the present invention is about 17 wt.% to about 23.5 wt.% of the total weight of the formulated composition. Formulating one or more waterproofing agents with a suncare composition is highly desirable, yet poses stability problems in balancing the waterproofing agent with the emulsion system and other components of the composition. High surfactant or emulsifier content raises this difficulty. After a sunscreen emulsion is applied to the skin, emulsifier components tend to become part of the oil phase, which remains on the skin. If there is excess emulsifier unbound in the oil phase, it more readily reforms an emulsion when water comes in contact with the skin and, thus, allows for oil phase active ingredients to be washed off the skin. Having a minimum amount of emulsifier necessary to maintain a given oil phase in a sunscreen composition minimizes this wash off effect and keeps the sunscreen actives on the skin.
Further, with less emulsifier, it is possible to use less waterproofing agent/film forming compound or to use a less efficient waterproofing agent/film forming compound than would otherwise be necessary to achieve a certain level of waterproofing. Less efficient waterproofing agent/film forming compounds are also less expensive than the higher efficiency components. The emulsion base of the present invention overcomes these difficulties.
The one or more film former/waterproofing agents is a hydrophobic material that imparts film forming and waterproofing characteristics to the emulsion. It has been unexpectedly found that the emulsion base of the present invention provides a stable base for formulating the one or more film former/waterproofing agents in ratios of 0.1 :7 to 7:0.1 film former/waterproofing agent to total amount of surfactants/emulsifiers in the total composition.
Suitable film former/waterproofing agent for use in the compositions of the present invention include, but is not limited to, acrylates/C-12-22 alkylmethacrylate copolymer, C30-38 olefin/isopropyl maleate/MA copolymer,
polyethylene, waxes, VP/dimethiconylacrylate/polycarbamyl polyglycol ester, butylated PVP, PVP/hexadecane copolymer, PVP/eicosene copolymer, tricontanyl PVP, Brassica Campestris/Aleuritis Fordi Oil copolymer, aminofunctional silicones, decamethyl cyclopentasiloxane (and) trimethylsiloxysilicate, octadecene/MA copolymer, or any combinations thereof.
In one embodiment, the one or more film former/waterproofing agents is acrylates/Cι2-22 alkylmethacrylate copolymer sold under the tradename Allianz OPT® by ISP. In another embodiment, the one or more film former/waterproofing agents is octadecene/MA copolymer sold under the tradename PA-18 by Chevron Philips.
One or more film formers/waterproofing agents may be present in the compositions of the present invention in an amount about 0.1 wt.% to about 5 wt.% of the total weight of the composition. Preferably, the one or more film formers/waterproofing agents are present in the compositions of the present invention in an amount about 1 wt.% to about 3 wt.% of the total weight of the composition. More preferably, the one or more film formers/waterproofing agents are present in the compositions of the present invention in an amount about 1.5 wt.% to about 2.5 wt.% of the total weight of the composition.
Furthermore, the emulsion base overcomes the inherent instability of formulating compositions with particular sunscreen agents, for example avobenzone or octyl methoxycinnamate. The emulsion base provides a stable platform for the formulation of compositions having one or more sunscreen agents. These compositions are stable and have aesthetic and skin feel properties that are desirable to the consumer.
When it is desired to formulate a suncare composition, one or more sunscreen agents may be formulated with the emulsion base and system of the present invention. The one or more sunscreen agents that can be used in the present invention must be capable of absorbing or blocking the harmful effects of ultraviolet radiation. In addition, they must be non-toxic and non-irritating when applied to the skin. Suitable sunscreen agents that may be used in formulating a suncare composition include, but are not
limited to, para-aminobenzoic acid (PABA), butyl methoxydibenzoylmethane (avobenzone), benzophenone-1 , benzophenone-2, benzophenone-3, benzophenone-4, benzophenone-6, benzophenone-8, benzophenone-12, methoxycinnamate, ethyl dihydroxypropyl-PABA, glyceryl PABA, homosalate, methyl anthranilate, octocrylene, octyl dimethyl PABA, octyl methoxycinnamate (octinoxate), octyl salicylate (octisalate), PABA, 2-phenylbenzimidazole-5-sulphonic acid, triethanolamine salicylate, 3-(4-methylbenzylidene)-camphor, red petrolatum, zinc oxide, titanium dioxide, 3-(4-methylbenzyldine)boran-2- one(methylbenzindinecamphor), benzotriazole, phenylbenzimidazole-5- sulfonic acid, methylene bis-benzotrizolyl tetramethylbutyl phenol, or any combinations thereof.
The one or more sunscreen agents may be present in compositions formulated according to the present invention at about 1 wt.% to about 40 wt.% of the total weight of the composition. The amount of sunscreen agent in the composition will vary in the above range depending on the sun protection factor (SPF) desired. Typically, the higher the SPF, the greater the total amount of sunscreen agent. In one embodiment of the present invention, the one or more sunscreen agents are included at about 2 wt.% to about 35 wt.% of the total weight of the composition to achieve a SPF of about 2 to about 50. In another embodiment of the present invention, the one or more sunscreen agents are included in an amount about 4 wt.% to about 24 wt.% of the total weight of the composition to achieve a SPF value of about 4 to about 30. In yet another embodiment of the present invention, the one or more sunscreen agents are present in an amount about 16 wt.% to about 24 wt.% of the total weight of the composition.
The emulsion base of the present invention provides a stable platform for formulating waterproof sunscreen compositions, while also maintaining the ability to contain high levels of oil phase within the emulsion. The emulsion base is stable using a broad range of oil phase volume. Suitable ranges for the oil phase volume of the composition are about 5% to about 45% by volume of the total composition.
Compositions formulated according to the present invention may include one or more secondary rheology modifying agents. Such secondary rheology modifying agents may be present in addition to any rheology modifying agents or thickeners in the emulsion base itself in order to further modify the aesthetics of the final composition. Suitable secondary rheology modifying agents for use in formulating compositions according to the present invention include, but are not limited to, one or more polymeric emulsifiers, thickening agents, synthetic and natural gum or polymer products, polysaccharide thickening agents, associative thickeners, rheological additives and/or stabilizers, oil-thickening agents, or any combinations thereof.
Preferably, the one or more secondary rheology modifying agents for use in compositions formulated according to the present invention include, but are not limited to, acrylates crosspolymer, acrylates/Cιo-30 alkylacrylate crosspolymer, polyacrylic acid, sodium polyacrylate, polyacrylate, acrylates/vinyl ester copolymer, PVP/decene copolymer, styrene/MA copolymer, acetamide MEA, acrylamides copolymer, acrylates copolymer, acrylates/steareth-20 methacrylate copolymer, acrylates/beheneth-25 methacrylate copolymer, PEG-150/decyl alcohol/SMDI copolymer, PVP, PVM/MA decadiene crosspolymer, carbomer, PEG crosspolymer, acrylates/palmeth-25 acrylates copolymer, polysaccharide, polyether-1 , sodium magnesium silicate, bentonite, trihydroxystearin, hydroxy stearate, aluminum-magnesium hydroxide stearate, acacia gum, xanthan gum, microcrystalline cellulose, cellulose gum, or any combinations thereof. More preferably, the one or more secondary rheology modifying agents are microcrystalline cellulose, cellulose gum, acrylates/C10-3o alkylacrylate crosspolymer, or any combinations thereof.
The amount of the one or more secondary rheology modifying agents that may be present in composition formulated according to the present invention is about 0.01 wt.% to about 10 wt.% of the total weight of the composition. Preferably, the one or more secondary rheology- modifying agent is present in an amount about 0.1 wt.% to about 5 wt.% of
the total weight of the composition. More preferably, the one or more secondary rheology-modifying agent is present in an amount about 0.4 wt.% to about 1.5 wt.% of the total weight of the composition.
Compositions formulated according to the present invention may also include one or more secondary diluents. The one or more secondary diluents are in addition to any diluents present in the emulsion base itself. Suitable secondary diluents include, but are not limited to, water, glycol, or any combinations thereof. Preferably, the additional diluent is water. The one or more secondary diluent is present in compositions formulated according to the present invention in an amount about 40 wt.% to about 90 wt.%, preferably about 45 wt.% to about 75 wt.%, and more preferably about 47 wt.% to about 51 wt.%, of the total weight of the composition.
Compositions formulated according to the present invention may include one or more secondary emollients. The one or more secondary emollients are in addition to any emollients present in the emulsion base itself. Examples of suitable secondary emollients include, but are not limited to cocoglyceride, cyclomethicone, dimethicone, dicapryl maleate, caprylic/capric triglyceride, isopropyl myristate, octyl stearate, mineral oil, lanolin oil, coconut oil, cocoa butter, olive oil, avocado oil, aloe extract, jojoba oil, castor oil, fatty acid such as oleic and stearic, fatty alcohol such as cetyl and hexadecyl, diisopropyl adipate, hydroxybenzoate esters, benzoic acid ester of C9-C15 alcohols, isononyl iso-nonanoate, alkane such as mineral oil, silicone such as dimethyl polysiloxane, ether such as polyoxypropylene butyl ether and polyoxypropylene cetyl ether, C-12-C15 alkyl benzoate, octyldodecyl neopentanoate, di-PPG-3 myristyl ether adipate, dipentaerythritol hexa C5.9 acid ester, tribehenin, cetyl palmitate, or any combinations thereof. Preferably, the one or more secondary emollients are octyldodecyl neopentanoate, Cι2-Cι5 alkyl benzoate, di- PPG-3 myristyl ether adipate, dipentaerythritol hexa C5-9 acid ester, tribehenin, cetyl palmitate, or any combinations thereof.
The one or more secondary emollients may be present in compositions formulated according to the present invention in an amount
about 0.1 wt.% to about 30 wt.% of the total weight of the composition. Preferably, the one or more secondary emollients are present in an amount about 1 wt.%) to about 20 wt.% of the total weight of the composition. More preferably, the one or more secondary emollients are present in an amount about 5 wt.% to about 10 wt. % of the total weight of the composition. The pH of the compositions of the present invention may be adjusted by one or more pH adjusters and/or chelating agents. For example, sodium hydroxide, triethanolamine, EDTA salt, or any combinations thereof, are suitable pH adjusters/chelating agents that may be included in compositions formulated according to the present invention. Preferably, the pH adjuster/chelating agent is triethanolamine, disodium EDTA, or any combinations thereof.
An effective amount of a pH adjuster and/or chelating agent is included to adjust the pH of the final compositions to about 3 to about 9. Preferably, the pH is adjusted to about 5 to about 8, and more preferably about 6 to about 7.
One or more secondary humectants may be used in the compositions of the present invention. The one or more secondary humectants are in addition to any humectant present in the emulsion base itself. Suitable secondary humectants include, but are not limited to, glycerin, propylene glycol, butylene glycol, sorbitol, PEG-4, aloe, or any combinations thereof. Preferably, the one or more secondary humectants is aloe.
One or more secondary humectants may be included in the compositions of the present invention in an amount about 0.01 wt.% to about 15 wt.% of the total weight of the composition. Preferably, the one or more secondary humectants are present in an amount about 0.01 wt.% to about 5 wt.% of the total weight of the composition. More preferably, the one or more secondary humectants are present in an amount about 0.05 wt.%) of the total weight of the composition.
One or more secondary preservatives may be formulated in the compositions of the present invention. The one or more secondary preservatives are in addition to any preservative in the emulsion base itself.
The one or more secondary preservatives may be present in the compositions formulated according to the present invention to provide additional preservative, antioxidant, and/or antimicrobial activity. Examples of secondary preservatives include, but are not limited to, diazolidinyl urea, iodopropynyl butylcarbamate, DMDM hydantoin, iodipropynyl butylcarbamate, chloromethylisotiazolinone, methylisothiazolinone, vitamin E and its derivatives including vitamin E acetate, vitamin C, butylated hydroxytoluene (BHT), butylparaben, ethylparaben, methylparaben, propylparaben, phenoxyethanol, or any combinations thereof. Preferably, the one or more secondary preservatives are BHT, tocopheryl acetate, DMDM hydantoin, iodopropynyl butylcarbamate, methyldibromo glutaronitrile, or any combinations thereof.
The one or more secondary preservatives may be present in an amount about 0.01 wt.% to about 2 wt.% of the total weight of the composition. Preferably, one or more secondary preservatives are present in an amount about 0.1 wt.% to about 1.5 wt.% of the total weight of the composition. More preferably, the one or more secondary preservatives may be present in an amount about 0.1 wt.%.
The emulsion base and system of the present invention can be used in the formulation of compositions in a broad range of product forms.
Examples of product forms that may be obtained using the emulsion base and system include cream, lotion, spray, gel, and milk.
The emulsion base itself and compositions formulated therefrom may be dispensed from a variety of containers. Examples of suitable containers for dispensing include tube, bottle, jar, and spray devices.
The emulsion base itself can be formulated using ordinary, simple equipment and does not require major laboratory alteration or specialized equipment.
The emulsion base may be used in a method of formulating cosmetic and dermatological compositions. The method includes providing an emulsion base according to the present invention and formulating with the emulsion base additional components to provide a desired composition with desired properties. Alternatively, the method includes formulating the
aqueous additional components with the aqueous phase of the emulsion base, formulating the oil phase additional components with the oil phase of the emulsion base, and combining the two phases, optionally with the addition of further components thereafter.
An example of a spray sunscreen composition formulated with an emulsion base of the present invention is set forth in Table 5.
Table 5: Spray Sunscreen Composition
Another example of a spray sunscreen composition formulated with mulsion base of the present invention is set forth in Table 6.
Table 6: Spray Sunscreen Composition
An example of a lotion sunscreen composition formulated with an emulsion base of the present invention is set forth in Table 7.
Table 7: Lotion Sunscreen Composition
LEXFEEL 350, which is dipentaerythritol hexa C5.9 acid esters, is available from Inolex.
CARBOPOL ULTREZ 21, which is acrylates/C10-3o alkyl acrylate crosspolymer, is available from Noveon.
Another example of a lotion sunscreen composition formulated with mulsion base of the present invention is set forth in Table 8.
Table 8: Lotion Sunscreen Composition
UV TITAN X263 is available from Kemira and includes titanium dioxide, alumina, sodium hexametaphosphate, and polyvinylpyrrolidone (PVP).
Yet another example of a lotion sunscreen composition formulated with an emulsion base of the present invention is set forth in Table 9.
Table 9: Lotion Sunscreen Composition
ALLIANZ OPT, which is an acrylates/Cι2-22 alkyl methylacrylate copolymer, is available from ISP.
The following is an example of a spray composition having an emulsion base of the present invention.
Table 10 Sunblock Lotion
CRODAMOL PMP is a PPG-2 Myristyl Ether Propionate, and is available from Croda.
The following is an example of a sunblock lotion composition having an emulsion base of the present invention.
Table 11 Sunblock Lotion
The following is an example of a sunblock lotion composition having mulsion base of the present invention.
Table 12 Sunblock Lotion
Claims
1. An emulsion base for formulating stable compositions comprising: one or more primary surfactants; and one or more co-surfactants, wherein the one or more primary surfactants to the one or more co- surfactants are present in the emulsion base in a ratio from about 1 :3.75 to about 3.75:1.
2. The emulsion base of claim 1 , wherein the ratio of the one or more primary surfactants to the one or more co-surfactants is from about 1 :2.67 to about 3:1.
3. The emulsion base of claim 1 , wherein the ratio of the one or more primary surfactants to the one or more co-surfactants is about 2.13:1.
4. The emulsion base of claim 1 , wherein the ratio of the one or more primary surfactants to the one or more co-surfactants is about 3:1.
5. The emulsion base of claim 1 , wherein the ratio of the one or more primary surfactants to the one or more co-surfactants is about 1 :2.67.
6. The emulsion base of claim 1 , wherein the ratio of the one or more primary surfactants is selected from the group consisting of sodium dicocoylethylenediamine PEG-15 sulfate and sodium lauroyl sulfate, ceteareth-20, lauryl glucoside, sodium dicocoylethylenediamine PEG-15 sulfate, sodium lauroyl sarcosinates, and any combinations thereof.
7. The emulsion base of claim 1 , wherein the ratio of the one or more co-surfactants is selected from the group consisting of the combination of behenyl alcohol, glyceryl stearate, glyceryl stearate citrate, and sodium dicocoylethylenediamine PEG-15 sulfate; the combination of glycerin stearate, cetearyl alcohol, sodium lauroyl lactylate, and lecithin, glyceryl monostearate; solid fatty alcohols; sorbitan trioleate; fatty esters; glyceryl stearate; and any combinations thereof.
8. The emulsion base of claim 1 , further comprising one or more of the following components a diluent, an, emollient, a humectant, a preservative, and a thickener.
9. The emulsion base of claim 1 , further comprising a diluent, wherein the diluent is present in an amount about 39 wt.% to about 87 wt.% of the total weight of the emulsion base.
10. The emulsion base of claim 1 , further comprising an emollient, wherein the emollient may be present in an amount about 14 wt.% to about 45 wt.% of the total weight of the emulsion base.
11. The emulsion base of claim 1 , further comprising a humectant, wherein the humectant is present in an amount about 3 wt.% to about 11 wt.% of the total weight of the emulsion base.
12. The emulsion base of claim 1 , further comprising a preservative, wherein the preservative is present in an amount about 0.1 wt.% to about 2 wt.% of the total weight of the emulsion base.
13. The emulsion base of claim 1 , further comprising a thickener, wherein the thickener is present in an amount from about 0.05 wt.% to about 3 wt.% of the total weight of the emulsion base.
14. The emulsion base of claim 1 , further comprising one or more ingredients selected from the group consisting of a sunscreen agent, a secondary surfactant, a secondary emollient, a skin-feel additive, a moisturizing agent, a film former/waterproofing agent , a bio-active ingredient, a pharmaceutical ingredient, a pH adjuster/chelating agent, a secondary preservative, an antimicrobial, a secondary humectant, a rheology modifying agent, a fragrance, a colorant; a plant extract, an absorbent, salicylic acid, alpha and beta hydroxy acid, a vitamin, and any combinations thereof.
15. The emulsion base of claim 1 , further comprising a sunscreen photostablizer.
16. The emulsion base of claim 15, further comprising a sunscreen booster.
17. The emulsion base of claim 1 , further comprising a sunscreen booster.
18. A stable composition comprising: an emulsion base having one or more primary surfactants and one or more co-surfactants, wherein the one or more primary surfactants to the one or more co-surfactants are present in a ratio from about 1:3.75 to about 3.75:1, .wherein the emulsion base is about 10 wt.% to about 25 wt.% of the total weight of the composition.
19. The composition of claim 18, wherein the ratio of the one or more primary surfactants to the one or more co-surfactants is from about 1 :2.67 to about 3:1.
20. The composition of claim 18, further comprising one or more film former/waterproofing agents.
21. The composition of claim 20, wherein the one or more film former/waterproofing agents to the one or more surfactants and co- surfactants are in the ratio of 0.1 :7 to 7:0.1 in the composition.
22. The composition of claim 18, further comprising one or more sunscreen agents.
23. The composition of claim 22, wherein the one or more sunscreens are present at about 1 wt.% to about 40 wt.% of the total weight of the composition.
24. The composition of claim 18, further comprising one or more secondary rheology modifying agents in an amount about 0.01 wt.% to about 10 wt.% of the total weight of the composition.
25. The composition of claim 18, further comprising one or more secondary diluents in an amount about 40 wt.% to about 90 wt.% of the total weight of the composition.
26. The composition of claim 18, further comprising one or more secondary emollients in an amount about 0.1 wt.% to about 30 wt.% of the total weight of the composition.
27. The composition of claim 18, further comprising an effective amount of a pH adjuster to adjust the pH of the compositions to about 3 to about 9.
28. The composition of claim 18, further comprising one or more secondary preservatives in an amount about 0.01 wt.% to about 2 wt.% of the total weight of the composition.
29. A flexible and stable emulsion base for formulating stable compositions comprising: one or more primary surfactants; one or more co-surfactants, wherein the one or more primary surfactants to the one or more co-surfactants are present in a ratio from about 1 :3.75 to about 3.75:1 ; and one or more of the following components a diluent, an, emollient, a humectant, a preservative, a solvent, and a thickener, wherein the emulsion base is about 10 wt.% to about 25 wt.% of the total weight of the composition.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0525553A GB2418360B (en) | 2003-05-29 | 2004-05-28 | Emulsion base for skin care compositions |
| CA2526626A CA2526626C (en) | 2003-05-29 | 2004-05-28 | Emulsion base for skin care compositions |
| AU2004242983A AU2004242983B2 (en) | 2003-05-29 | 2004-05-28 | Emulsion base for skin care compositions |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47445103P | 2003-05-29 | 2003-05-29 | |
| US60/474,451 | 2003-05-29 | ||
| US56706204P | 2004-04-30 | 2004-04-30 | |
| US60/567,062 | 2004-04-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2004105704A2 true WO2004105704A2 (en) | 2004-12-09 |
| WO2004105704A3 WO2004105704A3 (en) | 2005-08-04 |
Family
ID=33493386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2004/017174 WO2004105704A2 (en) | 2003-05-29 | 2004-05-28 | Emulsion base for skin care compositions |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8512683B2 (en) |
| AU (1) | AU2004242983B2 (en) |
| CA (1) | CA2526626C (en) |
| GB (1) | GB2418360B (en) |
| WO (1) | WO2004105704A2 (en) |
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| FR2891456A1 (en) * | 2005-09-30 | 2007-04-06 | Oreal | Cosmetic composition in oil-in-water emulsion form, useful as e.g. skin care and make-up products, comprises a polymeric surfactant and a tetrapolymer of methacrylic acid, methyl acrylate, butyl methacrylate and alkyl(meth)acrylate |
| WO2007054824A2 (en) * | 2005-09-30 | 2007-05-18 | L'oréal | O/w emulsion containing a gemini surfactant |
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Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| DE102004062775A1 (en) | 2004-12-21 | 2006-06-29 | Stockhausen Gmbh | Alcoholic pump foam |
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| KR102354352B1 (en) * | 2021-10-29 | 2022-01-21 | 한국콜마주식회사 | Oil-in- water cosmetic composition comprising physical sunscreen |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6395701B1 (en) * | 1997-10-23 | 2002-05-28 | Daniel Stedman Connor | Fatty acids, soaps, surfactant systems, and consumer products based on branched 17-carbon fatty acids |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0085334A3 (en) | 1982-01-25 | 1985-08-07 | PLOUGH, INC. (a Delaware corporation) | Substantive topical compositions |
| US5047232A (en) | 1986-09-29 | 1991-09-10 | Schering-Plough Healthcare Products, Inc. | Non-aqueous waterproof oil-based compositions and method of preparing same |
| US5587150A (en) | 1990-02-14 | 1996-12-24 | L'oreal | Photostable cosmetic screening composition containing a UV-A screening agent and an alkyl β, β-diphenylacrylate or α-cyano-β,β-diphenylacrylate |
| FR2658075B1 (en) | 1990-02-14 | 1992-05-07 | Oreal | PHOTOSTABLE FILTERING COSMETIC COMPOSITION CONTAINING A UV-A FILTER AND A BETA, BETA-DIPHENYLACRYLATE OR ALPHA-CYANO-BETA, BETA-DIPHENYLACRYLATE. |
| US5229104A (en) | 1991-04-29 | 1993-07-20 | Richardson-Vicks Inc. | Artificial tanning compositions containing positively charged paucilamellar vesicles |
| FR2720639B1 (en) | 1994-06-03 | 1996-07-05 | Oreal | Photoprotective cosmetic compositions and uses. |
| US5567420A (en) | 1994-11-16 | 1996-10-22 | Mceleney; John | Lotion which is temporarily colored upon application |
| US6033649A (en) | 1995-12-18 | 2000-03-07 | Roche Vitamins Inc. | Light screening agents |
| US5807561A (en) | 1996-05-23 | 1998-09-15 | Elizabeth Arden Co., Division Of Conopco, Inc. | Emulsifying system for a whitening cosmetic composition |
| US5770183A (en) | 1996-08-01 | 1998-06-23 | Linares; Francisco J. | High SPF (30 and over) waterproof sunblock compositions |
| US6197281B1 (en) | 1997-06-04 | 2001-03-06 | Ernest G. Stewart | Wet appliable, instant protection sunscreen and makeup and method of use |
| US5985251A (en) | 1997-12-01 | 1999-11-16 | Roche Vitamins Inc. | Light screening compositions |
| FR2778560B1 (en) | 1998-05-12 | 2001-06-01 | Oreal | USE OF CINNAMIC ACID OR AT LEAST ONE OF ITS DERIVATIVES IN A COMPOSITION FOR PROMOTING DEQUAMATION OF THE SKIN, AND COMPOSITION COMPRISING SAME |
| AU757342B2 (en) | 1998-06-22 | 2003-02-20 | Ciba Specialty Chemicals Holding Inc. | Sun screen formulations |
| US5989528A (en) | 1998-07-30 | 1999-11-23 | The Procter & Gamble Company | Sunscreen compositions |
| EP1104287B9 (en) | 1998-08-13 | 2012-12-19 | Sol-Gel Technologies Ltd. | Method for the preparation of oxide microcapsules loaded with functional molecules and the products obtained thereof |
| US20020006418A1 (en) | 1998-10-13 | 2002-01-17 | John Kung | Composition to enhance permeation of topical skin agents |
| WO2000035415A1 (en) | 1998-12-11 | 2000-06-22 | Cognis Deutschland Gmbh | Utilization of nanoscalar organic filters which provide protection against uv light |
| US6468509B2 (en) | 1998-12-18 | 2002-10-22 | Sol-Gel Technologies Ltd. | Sunscreen composition containing sol-gel microcapsules |
| US6238650B1 (en) | 1999-05-26 | 2001-05-29 | Sol-Gel Technologies Ltd. | Sunscreen composition containing sol-gel microcapsules |
| US6071501A (en) | 1999-02-05 | 2000-06-06 | The Procter & Gamble Company | Photostable UV protection compositions |
| NO20002309L (en) | 1999-05-12 | 2000-11-13 | Hoffmann La Roche | Photo-stable cosmetic light-shielding compositions |
| US6436375B1 (en) | 1999-05-25 | 2002-08-20 | Sol-Gel Technologies Ltd. | Method for obtaining photostable sunscreen compositions |
| EP1068866A3 (en) | 1999-07-12 | 2004-03-17 | Ciba SC Holding AG | Use of mixtures of micropigments for prevening tannig and to induce skin and hair lightening |
| DE19943668A1 (en) * | 1999-09-13 | 2001-03-15 | Rwe Dea Ag | Surfactant composition containing gemini surfactants and co-amphiphiles, their preparation and their use |
| FR2799965B1 (en) | 1999-10-22 | 2002-10-31 | Oreal | EMULSION-FREE EMULSIONS CONTAINING AT LEAST ONE INSOLUBLE ORGANIC UV FILTER |
| FR2799964B1 (en) | 1999-10-22 | 2002-07-26 | Oreal | EMULSIONS CONTAINING AT LEAST ONE INSOLUBLE ORGANIC UV FILTER AND AN ASSOCIATIVE POLYMER |
| FR2799963B1 (en) | 1999-10-22 | 2002-07-19 | Oreal | EMULSIONS CONTAINING AT LEAST ONE INSOLUBLE ORGANIC UV FILTER AND A NON-FILTERING ORGANOMODIFIED SILICONE |
| US6074630A (en) | 1999-11-23 | 2000-06-13 | Devillez; Richard L. | Delivery system for suncare products |
| US7250174B2 (en) | 1999-12-07 | 2007-07-31 | Schott Ag | Cosmetic, personal care, cleaning agent, and nutritional supplement compositions and methods of making and using same |
| US7083780B2 (en) | 1999-12-11 | 2006-08-01 | Cognis Deutschland Gmbh & Co. Kg | Cosmetic composition containing hydroxyethers |
| FR2804600B1 (en) | 2000-02-08 | 2002-03-22 | Oreal | PHOTOPROTECTIVE COMPOSITIONS COMPRISING A MIXTURE OF A POLYETHYLENE HAVING A TERMINAL CARBOXYLIC ACID FUNCTION AND A POLYETHYLENE |
| ATE479419T1 (en) | 2000-02-17 | 2010-09-15 | Basf Se | AQUEOUS DISPERSION OF WATER-INSOLUBLE ORGANIC UV FILTER SUBSTANCES |
| EP1129695A1 (en) | 2000-02-29 | 2001-09-05 | Basf Aktiengesellschaft | Cosmetic or dermatological sunscreen formulations |
| US6511673B1 (en) | 2000-05-10 | 2003-01-28 | Rohm And Haas Company | Microbicidal composition |
| DE10025558A1 (en) * | 2000-05-24 | 2001-11-29 | Merck Patent Gmbh | Topical composition containing at least one aryloxime and process for its preparation |
| US20030228267A1 (en) | 2001-07-09 | 2003-12-11 | Aust Duncan T. | Suncreen composition wit enhanced spf and water resistant properties |
| JP2002284705A (en) | 2001-01-19 | 2002-10-03 | Shiseido Co Ltd | Torpent |
| US6491902B2 (en) | 2001-01-29 | 2002-12-10 | Salvona Llc | Controlled delivery system for hair care products |
| US6500411B2 (en) | 2001-02-05 | 2002-12-31 | Amcol International Corporation | Multifunctional particulate additive for personal care and cosmetic compositions, and the process of making the same |
| US6436376B1 (en) | 2001-02-26 | 2002-08-20 | Societe L'oreal S.A. | Enhanced SPF UV-sunscreen/tricontanyl PVP photoprotecting (sprayable) formulations |
| KR100428817B1 (en) | 2001-05-24 | 2004-04-28 | 김원규 | Cosmetic composition having UV-blocking and slimming effects |
| US6432389B1 (en) | 2001-07-06 | 2002-08-13 | Societe L'oreal | High SPF nontacky/nongreasy UV-photoprotecting compositions comprising particulates of MMA crosspolymers |
| DE10141324A1 (en) * | 2001-08-28 | 2003-04-24 | Sasol Germany Gmbh | Sprayable O / W emulsions of low viscosity |
| FR2830773B1 (en) | 2001-10-11 | 2004-07-23 | Oreal | USE OF AMPHIPHILIC COPOLYMERS FOR STABILIZING DISPERSIONS OF INSOLUBLE ORGANIC COMPOUNDS FILTERING UV RADIATION, DISPERSIONS STABILIZED BY SUCH COPOLYMERS AND COSMETIC COMPOSITIONS CONTAINING THE SAME |
| US6485713B1 (en) | 2002-03-05 | 2002-11-26 | The C. P. Hall Company | Sunscreen compositions and methods and materials for producing the same |
| DE10218730A1 (en) | 2002-04-26 | 2003-11-20 | Wacker Chemie Gmbh | O / W emulsion |
| US7147841B2 (en) | 2002-06-17 | 2006-12-12 | Ciba Specialty Chemicals Corporation | Formulation of UV absorbers by incorporation in solid lipid nanoparticles |
| US6696490B2 (en) * | 2002-07-10 | 2004-02-24 | Unilever Home & Personal Care Usa Division Of Conopco, Inc. | Slow release insect repellent compounds and process for delivering active |
| US6664356B1 (en) * | 2003-01-23 | 2003-12-16 | Isp Investments Inc. | Leach resistant oil based carrier for cosmetically and pharmaceutically active agents |
-
2004
- 2004-05-28 AU AU2004242983A patent/AU2004242983B2/en not_active Ceased
- 2004-05-28 US US10/856,738 patent/US8512683B2/en active Active
- 2004-05-28 CA CA2526626A patent/CA2526626C/en not_active Expired - Fee Related
- 2004-05-28 WO PCT/US2004/017174 patent/WO2004105704A2/en active Application Filing
- 2004-05-28 GB GB0525553A patent/GB2418360B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6395701B1 (en) * | 1997-10-23 | 2002-05-28 | Daniel Stedman Connor | Fatty acids, soaps, surfactant systems, and consumer products based on branched 17-carbon fatty acids |
| US6602845B2 (en) * | 1997-10-23 | 2003-08-05 | The Procter & Gamble Company | Fatty acids, soaps, surfactant systems, and consumer products based thereon |
Cited By (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1539098A2 (en) * | 2002-09-20 | 2005-06-15 | Fmc Corporation | Cosmetic composition containing microcrystalline cellulose |
| EP1539098A4 (en) * | 2002-09-20 | 2008-09-24 | Fmc Corp | Cosmetic composition containing microcrystalline cellulose |
| US7815924B2 (en) | 2002-09-20 | 2010-10-19 | Fmc Corporation | Cosmetic composition containing microcrystalline cellulose |
| EP1762217A1 (en) * | 2005-09-09 | 2007-03-14 | Beiersdorf AG | Sunscreen composition comprising PPG-3 Benzyl Ether Myristate |
| FR2891456A1 (en) * | 2005-09-30 | 2007-04-06 | Oreal | Cosmetic composition in oil-in-water emulsion form, useful as e.g. skin care and make-up products, comprises a polymeric surfactant and a tetrapolymer of methacrylic acid, methyl acrylate, butyl methacrylate and alkyl(meth)acrylate |
| WO2007054824A2 (en) * | 2005-09-30 | 2007-05-18 | L'oréal | O/w emulsion containing a gemini surfactant |
| WO2007054824A3 (en) * | 2005-09-30 | 2007-10-04 | Oreal | O/w emulsion containing a gemini surfactant |
| FR2905855A1 (en) * | 2006-09-15 | 2008-03-21 | Oreal | Composition useful in non-therapeutic cosmetic treatment or make-up of keratinous matter, comprises ascorbic acid, a copolymer of styrenic monomer and carboxylic diacid with ethylene unsaturation, a wax and geminated amide surfactant |
| DE102007024138A1 (en) | 2007-05-23 | 2008-11-27 | Coty Prestige Lancaster Group Gmbh | Cosmetic skin cleanser |
| US9757313B2 (en) * | 2007-09-24 | 2017-09-12 | L'oreal | Cosmetic oil-in-water emulsion |
| FR2921262A1 (en) * | 2007-09-24 | 2009-03-27 | Oreal | COSMETIC EMULSION OF OIL TYPE IN WATER |
| EP2039339A3 (en) * | 2007-09-24 | 2012-06-20 | L'Oréal | Oil-in-water type cosmetic emulsion |
| EP2039339A2 (en) * | 2007-09-24 | 2009-03-25 | L'oreal | Oil-in-water type cosmetic emulsion |
| DE102007051614A1 (en) | 2007-10-24 | 2009-04-30 | Coty Prestige Lancaster Group Gmbh | Retinol-containing cosmetic product |
| DE102007055008A1 (en) | 2007-11-14 | 2009-06-10 | Coty Prestige Lancaster Group Gmbh | Cosmetic product for the protection of the skin against environmental influences |
| FR2924930A1 (en) * | 2007-12-18 | 2009-06-19 | Oreal | OIL-IN-WATER PHOTOPROTECTIVE EMULSIONS FLUIDS CONTAINING GEMINE SURFACTANTS AND A RETICULATED COPOLYMER OF METHACRYLIC ACID AND C1-C4 ALKYL ACRYLATE; PROCESS FOR THE PREPARATION OF THESE EMULSIONS |
| WO2009077272A1 (en) * | 2007-12-18 | 2009-06-25 | L'oreal | Fluid oil-in-water sunscreen emulsions containing gemini surfactants and a crosslinked copolymer of methacrylic acid and of c1-c4 alkyl acrylate |
| CN105708730A (en) * | 2007-12-18 | 2016-06-29 | 莱雅公司 | Fluid oil-in-water sunscreen emulsions containing gemini surfactants and a crosslinked copolymer of methacrylic acid and of c1-c4 alkyl acrylate |
| CN101896229A (en) * | 2007-12-18 | 2010-11-24 | 莱雅公司 | The flow-like oil-in-water ultra light sun block lotion that contains the cross-linked copolymer of binode configuration surfactant and methacrylic acid and acrylic acid C1-C4 Arrcostab |
| US20110027202A1 (en) * | 2007-12-18 | 2011-02-03 | Didier Candau | Fluid oil-in-water sunscreen emulsions containing gemini surfactants and a crosslinked copolymer of methacrylic acid and of c1-c4 alkyl acrylate |
| DE102008004665A1 (en) | 2008-01-11 | 2009-07-16 | Coty Prestige Lancaster Group Gmbh | Cosmetic composition with anti-aging effect |
| DE102008004664A1 (en) | 2008-01-11 | 2009-07-23 | Coty Prestige Lancaster Group Gmbh | Sunscreen cosmetic kit and cosmetic method for the treatment of sensitive skin |
| DE102008022041A1 (en) | 2008-04-29 | 2009-11-05 | Coty Prestige Lancaster Group Gmbh | Cosmetic product with delayed retinol release |
| FR2967056A1 (en) * | 2010-11-05 | 2012-05-11 | Oreal | AQUEOUS FLUID SOLAR COMPOSITION BASED ON A SUPERABSORBENT POLYMER AND A RETICULATED METHACRYLIC ACID COPOLYMER AND C 1 -C 4 ALKYL ACRYLATE. |
| WO2012059348A1 (en) * | 2010-11-05 | 2012-05-10 | L'oreal | Fluid aqueous antisun composition based on a superabsorbent polymer and a crosslinked copolymer of methacrylic acid and of a c1-c4 alkyl acrylate |
| US9925132B2 (en) | 2010-11-05 | 2018-03-27 | L'oreal | Fluid aqueous antisun composition based on a superabsorbent polymer and a crosslinked copolymer of methacrylic acid and of a C1-C4 alkyl acrylate |
| CN103987372A (en) * | 2011-12-08 | 2014-08-13 | 化工产品开发公司Seppic | Novel oil-in-water emulsions enriched with salt, which are stabilized using natural gums, highly viscous, and stable over time |
| US9192562B2 (en) | 2013-09-18 | 2015-11-24 | L'oreal | High color intensity and easily removable mascara |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2526626A1 (en) | 2004-12-09 |
| US8512683B2 (en) | 2013-08-20 |
| AU2004242983A1 (en) | 2004-12-09 |
| AU2004242983B2 (en) | 2008-01-03 |
| US20050152931A1 (en) | 2005-07-14 |
| GB2418360A (en) | 2006-03-29 |
| GB2418360B (en) | 2007-07-11 |
| GB0525553D0 (en) | 2006-01-25 |
| CA2526626C (en) | 2012-08-28 |
| WO2004105704A3 (en) | 2005-08-04 |
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