WO2004064648A1 - Venous anti-reflux implant - Google Patents
Venous anti-reflux implant Download PDFInfo
- Publication number
- WO2004064648A1 WO2004064648A1 PCT/US2003/040249 US0340249W WO2004064648A1 WO 2004064648 A1 WO2004064648 A1 WO 2004064648A1 US 0340249 W US0340249 W US 0340249W WO 2004064648 A1 WO2004064648 A1 WO 2004064648A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- reservoir
- venous
- reflux device
- vein segment
- housing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/08—Wound clamps or clips, i.e. not or only partly penetrating the tissue ; Devices for bringing together the edges of a wound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/122—Clamps or clips, e.g. for the umbilical cord
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00535—Surgical instruments, devices or methods, e.g. tourniquets pneumatically or hydraulically operated
- A61B2017/00557—Surgical instruments, devices or methods, e.g. tourniquets pneumatically or hydraulically operated inflatable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B2017/12004—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord for haemostasis, for prevention of bleeding
Definitions
- Venous valves are typically bicuspid valves that are forced together to prevent retrograde flow of blood while permitting forward flow to the heart.
- the forward flow occurs when the hydrostatic pressure below the valve exceeds the closing pressure of the valve. This happens, for example, when the calf muscle constricts on the venous system (calf muscle pump) or the forward hydrostatic pressure of the pooling venous blood exceeds the weight of blood above the valve, forcing it to open.
- calf muscle constricts on the venous system (calf muscle pump) or the forward hydrostatic pressure of the pooling venous blood exceeds the weight of blood above the valve, forcing it to open.
- an incompetent valve attempts to close in response to a pressure gradient across the valve, however, the valve leaflets do not seal properly such that retrograde flow of blood will occur.
- venous stasis disease develops.
- Venous vascular insufficiency results in disabling leg swelling and ulceration in about 1,000,000 Americans annually.
- the treatment of choice is leg elevation to facilitate blood flow to the heart and high pressure hosiery to provide the required hydrostatic pressure below the incompetent valve (s).
- leg elevation to facilitate blood flow to the heart
- high pressure hosiery to provide the required hydrostatic pressure below the incompetent valve (s).
- patient compliance for these treatments is poor, resulting in chronic severe disability for those affected.
- the invention provides such a device by providing an implantable compliant collar that advantageously responds to positional changes of the patient in a manner corresponding to normal venous hemodynamics .
- an inflatable collar is provided that, according to the invention, is comprised of a rigid housing or frame for being applied to the target vein such as by snapping the collar around the vein.
- the collar of the invention may be applied to, e.g., the femoral vein and/or popliteal vein.
- a flexible membrane assembly is provided inside the shell of the collar for selectively constricting the vein segment within the shell .
- the inner membrane assembly defines alone or with the rigid outer shell at least one and preferably two or more compartments. At least one of the compartments is in flow communication with a reservoir.
- the reservoir is configured and disposed so that when the patient is standing erect, media flows from the reservoir into the at least one compartment to fill the same and gently close the vein disposed within the rigid shell segment, thereby preventing reflux toward the foot.
- the flexible membrane can still act as a one way vein valve because the vein is still able to empty in a forward flow fashion toward the heart when the pressure in the venous circulation below the collar exceeds the pressure of the media behind the flexible membrane.
- the reservoir is further configured and disposed so that when the patient is supine, the media flows from the at least one compartment to at least partially return to the reservoir, so as to release the force gently closing the vein, such that blood can more freely flow along its return path to the heart.
- a venous anti-reflux device comprising a fluid reservoir and a collar assembly, said collar assembly including a flexible membrane defining at least one compartment in flow communication with said fluid reservoir and a shell for supporting said at least one compartment in surrounding relation to a target vein segment, said media reservoir providing a pressure head of media for filling and distending said flexible membrane when said reservoir is disposed vertically above said collar assembly, thereby to constrict a flow passage through the target vein segment .
- the invention may also be embodied in a method for selectively constricting a vein segment for preventing retrograde venous flow comprising providing an implantable device including: a columnar fluid reservoir and a collar assembly, said collar assembly including a flexible membrane defining at least one compartment in flow communication with said fluid reservoir and a shell containing the flexible bladder; and mounting the collar assembly in surrounding relation to a target vein segment so that the columnar reservoir is disposed in parallel to and along a portion of the vein segment downstream, relative to antigrade flow, from the collar assembly whereby when the vein segment is disposed in a generally vertical orientation, said fluid reservoir defines a pressure head of media for filling and distending said flexible bladder, thereby to constrict the target vein segment.
- FIGURE 1 is a schematic perspective view illustrating a cuff according to the invention in an unsecured position ready for application to a target vein segment;
- FIGURE 2 is a perspective view of an extra- vascular implant embodying the invention disposed in surrounding relation to a target vein segment;
- FIGURE 3 is a schematic top plan view of the extra-vascular implant of FIGURE 2 and with the vein shown in collapsed form within the cuff;
- FIGURE 4A is a cross-sectional view taken along line IV-IV in FIGURE 3 before the flexible membrane has been filled and omitting the vein for clarity;
- FIGURE 4B is a schematic cross-sectional view taken along line IV-IV of FIGURE 3 showing the filled membrane according to a first embodiment of the invention.
- FIGURE 4C is a cross-sectional view taken along line IV-IV in FIGURE 3 showing the filled membrane according to a second embodiment of the invention and omitting the vein for clarity.
- FIGURE 1 An example of an inflatable collar or cuff device 10 embodying the invention is illustrated in the accompanying FIGURES.
- the device is comprised of a reservoir portion 12 and a collar or cuff portion 14 in fluid flow communication with the reservoir.
- the collar portion 14 includes a rigid housing or shell 16 which is provided to enable the collar to be fixedly secured in surrounding relation to a target segment 18 of the patient's vein.
- the shell 16 is formed in two parts 20,22 that are hinged together so that they can be pivoted from an open configuration as shown in FIGURE 1 to a closed configuration as shown in FIGURES 2 and 3 to surround the target vein segment 18.
- typically an artery 28 will be disposed in parallel side by side relation to the target vein segment 18.
- one of the shell halves is recessed as at 30 to accommodate the artery.
- the shell parts are hinged at an integral, living hinge 24. When the shell parts are pivoted to the closed configuration of FIGURES 2-3, they are secured together.
- one or more sutures is looped around the shell to hold the shell in its closed disposition.
- circumferential grooves 26 as schematically shown in FIGURES 4A-4C may be defined about the outer circumference of the shell 16 for receiving and properly positioning the suture material .
- a protrusion such as a knob or hook may be provided so that the shell halves 20,22 snap and secure together or to receive e.g., suture material.
- the cuff has a height of about 1 cm and an interior diameter of the shell is between about 1.5 and 2 cm to encompass a variety of vein diameters .
- an inflatable membrane or bladder assembly for selectively receiving media from the reservoir 12, as described in greater detail hereinbelow.
- the shell halves 20,22 are generally C-shaped in vertical section to define an inflatable membrane receiving pocket.
- the inflatable membrane or bladder assembly is preferably comprised of at least two compartments respectively defined by the membrane that are closed but for their communication with each other and with the reservoir 12.
- the inflatable membrane assembly is provided as two inflatable membrane compartments 44,46, communication between the membrane compartments is provided adjacent the hinge 24 and media flows into the inflatable membrane assembly via conduit 32 and port 34 as illustrated e.g., in FIGURES 1 and 4.
- the membrane assembly may be comprised of inflatable membranes or bladders.
- the fillable compartments of the membrane assembly are defined by membranes suitably secured to the shell halves, so that the fillable compartments are defined between the flexible membranes and the respective wall of the respective shell half.
- FIGURE 4A schematically illustrates the closed shell with the membrane (s) 40,42 in an uninflated or not fully inflated configuration so that blood is free to flow through the vein segment 18.
- the membrane is preformed or distendable so that it will transition from the unfilled configuration of FIGURE 4A to the fully inflated configuration of FIGURES 3, 4B and/or 4C when media flows from the reservoir to the compartments 44 , 46 ;44 ' , 46 ' .
- the fillable compartment (s) can be defined by separately formed bladders secured within the shell halves and in flow communication with port 34.
- the fillable compartment (s) define a vein receiving opening 36 when the shell 16 is secured closed.
- a gap G is still defined between opposing sides of the filled compartments 44, 46; 44 ' ,46' , as illustrated in FIGURES 3, 4B, and 4C.
- This gap prevents the membranes 40 , 42 ;40 ' , 42 ' from compressing the walls of the vein 18 on each other.
- the opposing membrane walls in a collar with two compartments filled with fluid should preferably not get closer than, e.g., the thickness of two vein walls (2 mm) .
- the compartments are preferably inflatable but not expandable so that the compartments define a prescribed shape when fully inflated.
- the protruding compartments are generally parabolic in vertical section.
- the closest point between the inflated compartments 44 ',46' is at one vertical end of the shell 16', e.g., the vertically upper end. While two fillable compartments are provided in the illustrated embodiment, it is to be understood that additional fillable compartments may be provided as deemed necessary or desirable to define the proper inflated bladder profile for occluding the blood vessel when the patient is standing erect.
- the membrane or bladder compartments are selectively filled with a media that flows thereto from a reservoir 12.
- the media reservoir has a longitudinal axis that extends substantially perpendicular to a horizontal plane of the collar portion so that it will be disposed vertically above the collar assembly when the patient is standing erect.
- the fluid reservoir is defined as a fluid column disposed generally in parallel to the target vein so as to be exposed to the same gravitational and positional influences as the patient's venous system.
- the fluid reservoir may be formed from a flexible membrane or, more preferably, as a rigid or semi-rigid structure, as deemed necessary or desirable to provide for a reliable flow connection to the inflatable bladder and to resist compressive external forces which may preclude re-filing of the reservoir when the patient is supine.
- the fluid reservoir would be implanted in continuity with the collar 12 in the sub-contaneous space.
- the size of the column is defined by, e.g., the density of the fluid within it and by the weight of the venous blood between the last competent valve and the collar implant site. The latter may be calculated invasively from duplex scan data. Also, implantation of two or more devices in series would shorten the length of each column. This is because the reservoir size dictates how much retrograde flow pressure can be resistant by the device and multiple devices will reduce the amount of retrograde flow each device is designed to resist.
- the media contained within the reservoir may be either a fluid, a solid or a combination thereof.
- the media provided in the reservoir is a biocompatible fluid.
- An exemplary fluid is saline which would be provided to mimic a column of blood.
- a relatively large/long fluid reservoir would be required to mimic the pressure of a corresponding column of blood.
- suitable fluids will have a low viscosity and high density to provide appropriate flowability and pressure as the patient's position changes. It will be appreciated that a relatively limited flow of fluid from the reservoir to the inflatable membrane in conjunction with the pressure head created by the column of fluid will be sufficient to advantageously allow the venous segment to resist retrograde flow while allowing the desired anti-flux flow.
- the media contained in the reservoir may be a solid, such as flowable particulate matter.
- a solid and a fluid can be paired, the fluid providing the flowability for compartment filling and displacement of the membranes, and the solid providing the appropriate force (pressure) to displace the fluid.
- the weight (solid) would act as a force generator and the fluid as the vein closure actuator.
- the reservoir 12 itself is preferably provided as an externally supported graft disposed in the subcutaneous tissue and fluidly coupled to the cuff, as mentioned above.
- the reservoir may be formed from PTFE so that the flow of media from the reservoir to the compartments of the collar is due to the patient ' s position rather than external compressive forces on the reservoir.
- the media connection from the reservoir to the cuff may be a 5mm diameter conduit 32 that is e.g., friction fit to a port 34 defined in the wall of the collar shell half 20. A suture may be secured around the friction fit components to enhance the security of the connection.
- the proposed constricting collar of the invention does not sit over the existing incompetent vein valve, can accommodate changes in pressure and volume, and does not have to be configured to precisely fit the vein segment since the only absolute dimension is the distance between opposing sides of the deformable membranes within the rigid shell. This dimension prevents the membrane from compressing and crushing the walls of the vein on each other.
- the inflatable cuff of the invention advantageously mimics the venous circulation by defining a parallel circuit that responds to gravity just as the venous circulation does but prevents deleterious reverse flow which causes venous hypertension and skin ulceration at the ankles.
- the device is provided wholly outside the blood stream so that the endothelial layer within the vein is not disrupted.
- the device of the invention is also easy to implant, requiring little time to implant and requiring only the skill of a general surgeon.
- long graft tunnels are routinely created for routing arterial grafts.
- the same equipment may be used for tunneling to accommodate the columnar reservoir of the invention.
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- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Reproductive Health (AREA)
- Vascular Medicine (AREA)
- Prostheses (AREA)
- External Artificial Organs (AREA)
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003293580A AU2003293580A1 (en) | 2003-01-15 | 2003-12-18 | Venous anti-reflux implant |
JP2004566940A JP2006512989A (en) | 2003-01-15 | 2003-12-18 | Implant for venous reflux prevention |
EP03790529A EP1585447A1 (en) | 2003-01-15 | 2003-12-18 | Venous anti-reflux implant |
CA002512609A CA2512609A1 (en) | 2003-01-15 | 2003-12-18 | Venous anti-reflux implant |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44001903P | 2003-01-15 | 2003-01-15 | |
US60/440,019 | 2003-01-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2004064648A1 true WO2004064648A1 (en) | 2004-08-05 |
Family
ID=32771769
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/040249 WO2004064648A1 (en) | 2003-01-15 | 2003-12-18 | Venous anti-reflux implant |
Country Status (8)
Country | Link |
---|---|
US (1) | US20040138684A1 (en) |
EP (1) | EP1585447A1 (en) |
JP (1) | JP2006512989A (en) |
KR (1) | KR20050092767A (en) |
AU (1) | AU2003293580A1 (en) |
CA (1) | CA2512609A1 (en) |
TW (1) | TW200501913A (en) |
WO (1) | WO2004064648A1 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007140564A2 (en) * | 2006-06-06 | 2007-12-13 | Luiz Gonzaga Granja Filho | Extraluminal stent type prosthesis for anastomosis |
WO2011102958A1 (en) * | 2010-02-17 | 2011-08-25 | Medtronic Vascular Inc. | Apparatus for creating a venous valve from autologous tissue |
US9504572B2 (en) | 2010-02-17 | 2016-11-29 | Medtronic Vascular, Inc. | Apparatus and methods for creating a venous valve from autologous tissue |
US10182823B2 (en) | 2016-02-17 | 2019-01-22 | Atricure, Inc. | Inflatable atrial appendage occlusion apparatus and methods |
Families Citing this family (22)
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US6973617B1 (en) * | 2000-05-24 | 2005-12-06 | Cisco Technology, Inc. | Apparatus and method for contacting a customer support line on customer's behalf and having a customer support representative contact the customer |
WO2005096988A1 (en) | 2004-04-01 | 2005-10-20 | Cook Incorporated | A device for retracting the walls of a body vessel with remodelable material |
US20060264982A1 (en) * | 2005-05-20 | 2006-11-23 | Viola Frank J | Gastric restrictor assembly and method of use |
US7691053B2 (en) * | 2005-05-20 | 2010-04-06 | Tyco Healthcare Group Lp | Gastric restrictor assembly and method of use |
US7666180B2 (en) * | 2005-05-20 | 2010-02-23 | Tyco Healthcare Group Lp | Gastric restrictor assembly and method of use |
US8435203B2 (en) | 2007-06-20 | 2013-05-07 | Covidien Lp | Gastric restrictor assembly and method of use |
US7846199B2 (en) | 2007-11-19 | 2010-12-07 | Cook Incorporated | Remodelable prosthetic valve |
US20120157762A1 (en) * | 2010-12-16 | 2012-06-21 | Ryan Darnell | System and method for treating erectile dysfunction |
EP3113692A4 (en) | 2011-01-11 | 2018-03-14 | Amsel Medical Corporation | Method and apparatus for occluding a blood vessel and/or other tubular structures |
US10820895B2 (en) | 2011-01-11 | 2020-11-03 | Amsel Medical Corporation | Methods and apparatus for fastening and clamping tissue |
JP2014508571A (en) * | 2011-01-11 | 2014-04-10 | アムセル・メディカル・コーポレーション | Method and apparatus for treating varicose veins |
US10398445B2 (en) | 2011-01-11 | 2019-09-03 | Amsel Medical Corporation | Method and apparatus for clamping tissue layers and occluding tubular body structures |
FR2988287B1 (en) * | 2012-03-26 | 2017-01-27 | Medical Innovation Dev | ADJUSTABLE VASCULAR RING, MEDIUM FOR TREATING THE SFS SYNDROME AND IMPLANTABLE NEEDS COMPRISING SUCH A RING, MOLD AND METHOD OF OBTAINING SUCH A RING |
CN110101422A (en) | 2013-05-07 | 2019-08-09 | 阿姆泽尔医药公司 | For occluding vascular and/or the method and apparatus that two objects are fixed together |
CN103519863B (en) * | 2013-10-28 | 2017-02-08 | 胡佑伦 | Flow-limiting external vascular stent |
CN103784179B (en) * | 2014-01-22 | 2016-05-18 | 李宝童 | Blood vessel restraint device |
JP6466120B2 (en) * | 2014-09-24 | 2019-02-06 | 学校法人大阪医科薬科大学 | Artificial blood flow control device |
GB2545667A (en) * | 2015-12-21 | 2017-06-28 | Balatech Ltd | Flow control valves |
EP3412229A1 (en) * | 2017-06-07 | 2018-12-12 | Servizo Galego de Saúde (SERGAS) | Surgery multichannel device |
US10548604B2 (en) * | 2018-01-05 | 2020-02-04 | Richard A Rizzolo | Slow blood vessel occlusion apparatus |
FR3092486B1 (en) | 2019-02-13 | 2021-11-12 | Marc Bouiller | Hydraulic implant |
DE102021106199A1 (en) | 2021-03-15 | 2022-09-15 | Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen, Körperschaft des öffentlichen Rechts | Implant for intermittent occlusion of a vessel |
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US4256094A (en) * | 1979-06-18 | 1981-03-17 | Kapp John P | Arterial pressure control system |
US4549531A (en) * | 1982-04-26 | 1985-10-29 | Medical Engineering Corporation | Artificial sphincter with inflatable cuff |
US5454826A (en) * | 1993-02-26 | 1995-10-03 | Mineluba Co., Ltd. | Temporary clip with balloon activation means for controlling blood flow |
US6616624B1 (en) * | 2000-10-30 | 2003-09-09 | Cvrx, Inc. | Systems and method for controlling renovascular perfusion |
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FR2534801A1 (en) * | 1982-10-21 | 1984-04-27 | Claracq Michel | DEVICE FOR PARTIALLY OCCLUDING A VESSEL, PARTICULARLY OF THE CAUDAL CAVE VEIN, AND CONSTITUENT PART THEREOF |
US4708140A (en) * | 1986-05-08 | 1987-11-24 | Baron Howard C | Atraumatic vascular balloon clamp |
EP0276254A4 (en) * | 1986-07-17 | 1989-07-26 | Quotidian No 100 Pty Ltd | Correction of incompetent venous valves. |
CA2054728C (en) * | 1989-05-31 | 2003-07-29 | Rodolfo C. Quijano | Biological valvular prosthesis |
JP2874934B2 (en) * | 1990-02-08 | 1999-03-24 | 三菱化学株式会社 | Production of .ALPHA.-olefin polymer |
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-
2003
- 2003-12-17 TW TW092135820A patent/TW200501913A/en unknown
- 2003-12-18 AU AU2003293580A patent/AU2003293580A1/en not_active Abandoned
- 2003-12-18 KR KR1020057013213A patent/KR20050092767A/en not_active Application Discontinuation
- 2003-12-18 JP JP2004566940A patent/JP2006512989A/en active Pending
- 2003-12-18 US US10/737,754 patent/US20040138684A1/en not_active Abandoned
- 2003-12-18 WO PCT/US2003/040249 patent/WO2004064648A1/en active Application Filing
- 2003-12-18 EP EP03790529A patent/EP1585447A1/en not_active Withdrawn
- 2003-12-18 CA CA002512609A patent/CA2512609A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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US4256094A (en) * | 1979-06-18 | 1981-03-17 | Kapp John P | Arterial pressure control system |
US4549531A (en) * | 1982-04-26 | 1985-10-29 | Medical Engineering Corporation | Artificial sphincter with inflatable cuff |
US5454826A (en) * | 1993-02-26 | 1995-10-03 | Mineluba Co., Ltd. | Temporary clip with balloon activation means for controlling blood flow |
US6616624B1 (en) * | 2000-10-30 | 2003-09-09 | Cvrx, Inc. | Systems and method for controlling renovascular perfusion |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007140564A2 (en) * | 2006-06-06 | 2007-12-13 | Luiz Gonzaga Granja Filho | Extraluminal stent type prosthesis for anastomosis |
WO2007140564A3 (en) * | 2006-06-06 | 2008-08-14 | Filho Luiz Gonzaga Granja | Extraluminal stent type prosthesis for anastomosis |
WO2011102958A1 (en) * | 2010-02-17 | 2011-08-25 | Medtronic Vascular Inc. | Apparatus for creating a venous valve from autologous tissue |
US8292948B2 (en) | 2010-02-17 | 2012-10-23 | Medtronic Vascular, Inc. | Apparatus and methods for creating a venous valve from autologous tissue |
US9504572B2 (en) | 2010-02-17 | 2016-11-29 | Medtronic Vascular, Inc. | Apparatus and methods for creating a venous valve from autologous tissue |
US10182823B2 (en) | 2016-02-17 | 2019-01-22 | Atricure, Inc. | Inflatable atrial appendage occlusion apparatus and methods |
US10959736B2 (en) | 2016-02-17 | 2021-03-30 | Atricure, Inc. | Inflatable atrial appendage occlusion apparatus and methods |
Also Published As
Publication number | Publication date |
---|---|
TW200501913A (en) | 2005-01-16 |
JP2006512989A (en) | 2006-04-20 |
CA2512609A1 (en) | 2004-08-05 |
EP1585447A1 (en) | 2005-10-19 |
AU2003293580A1 (en) | 2004-08-13 |
US20040138684A1 (en) | 2004-07-15 |
KR20050092767A (en) | 2005-09-22 |
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