WO2004007658A2 - Cleaners for the control and removal of allergens - Google Patents
Cleaners for the control and removal of allergens Download PDFInfo
- Publication number
- WO2004007658A2 WO2004007658A2 PCT/US2003/016398 US0316398W WO2004007658A2 WO 2004007658 A2 WO2004007658 A2 WO 2004007658A2 US 0316398 W US0316398 W US 0316398W WO 2004007658 A2 WO2004007658 A2 WO 2004007658A2
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- WIPO (PCT)
- Prior art keywords
- cleaner
- allergen
- set forth
- wipe
- agglutinin
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
- C11D17/04—Detergent materials or soaps characterised by their shape or physical properties combined with or containing other objects
- C11D17/049—Cleaning or scouring pads; Wipes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/382—Vegetable products, e.g. soya meal, wood flour, sawdust
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/384—Animal products
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Definitions
- the present invention relates to cleaners for removing allergens from various surfaces including human and animal skin and hair. More specifically, the present invention relates to cleaners comprising a wipe, such as a wet or dry wipe, comprising an additive comprising a lectin, a protease, and/or an enzyme inhibitor capable of binding an allergen, such as animal dander, to the cleaner and removing it from a surface. Additionally, the additive may be capable of reducing the allergenicity of the allergen upon contacting the allergen.
- Allergens are substances that trigger allergic reactions in a host organism such as a human, and are typically small, acidic glycoproteins . Many allergens are members of a superfamily of extracellular proteins commonly referred to as lipocalins. Allergens such as animal dander and other animal secretions, such as saliva and urine, are commonplace in many households and businesses where animals and/or pets are present. Other allergens commonly found in the home include plant pollens, fungi allergens, cockroach allergens, and dust mite feces.
- Animal dander such as cat or dog dander for example, is one of the most common allergens.
- Animal dander is not only the hair or fur of the animal, but includes minute skin scales that fall from the hair, feathers, and skin of all warm-blooded animals.
- Animal dander carries antigens that can cause allergic reactions in sensitive people. Typically, older animals produce more skin- scale type dander than young ones because their skin is drier.
- the present invention relates to cleaners comprising wet or dry wipes that can be used to remove allergens, such as animal dander and house dust mite feces, from various surfaces including human skin, animal coats and skin, and tables and countertops.
- the wipes utilized to form the cleaners of the present invention have immobilized thereon or therein an additive, such as a lectin, a protease, and/or an enzyme inhibitor, that can bind the allergen to the wipe substrate such that the allergen can be easily removed from the surface.
- an additive such as a lectin, a protease, and/or an enzyme inhibitor
- the cleaner comprises a protease or an enzyme inhibitor alone or in combination with a lectin
- the protease or enzyme inhibitor may provide the additional benefit of chemically altering the allergen to reduce its allergenicity.
- the additive-containing cleaners of the present invention are suitable for use on hard surfaces such as tables, countertops, and electronic boards, as well as on humans and animals to remove various allergens.
- the present invention is directed to a cleaner for removing an allergen from a surface.
- the cleaner comprises a wipe and an allergen binding lectin for binding the allergen to the wipe and removing it from the surface .
- the present invention is further directed to a cleaner for removing animal dander from a surface.
- the cleaner comprises a wipe and an additive.
- the additive is present on the wipe in an amount of from about 0.00001% to about 1% (by total weight of the treated cleaner) and has a residue affinity for N-acetylgalactosamine residues.
- the present invention is further directed to a cleaner for reducing the allergenicity of an allergen located on a surface.
- the cleaner comprises a wipe and an allergen cleaving protease for cleaving the allergen to reduce the allergenicity of the allergen.
- the present invention is further directed to a cleaner for reducing the allergenicity of an allergen located on a surface.
- the cleaner comprises a wipe and an enzyme inhibitor for chemically reacting with the allergen to reduce the allergenicity of the allergen.
- the present invention is further directed to a method for removing an allergen from a surface.
- the method comprises contacting the allergen on the surface with a cleaner.
- the cleaner comprises a wipe and an allergen binding lectin for binding the allergen to the wipe and removing the allergen from the surface.
- the present invention is further directed to a method for removing an allergen from a surface.
- the method comprises contacting the allergen on the surface with a cleaner.
- the cleaner comprises a wipe and an allergen binding protease for cleaving the allergen and binding the allergen onto the wipe and removing the allergen from the surface .
- the present invention is further directed to a method for removing an allergen from a surface.
- the method comprises contacting the allergen on the surface with a cleaner comprised of a wipe and an enzyme inhibitor.
- the enzyme inhibitor chemically reacts with the allergen to reduce the allergenicity of the allergen and binds the allergen to the cleaner.
- cleaners comprising wet or dry wipes that have immobilized thereon or therein one or more additives that attract and bind numerous allergens, such as animal dander, to the wipe can be utilized to remove various allergens from hard surfaces.
- the immobilized additive can comprise a lectin, a protease, and/or an enzyme inhibitor, each of which will attract various allergens and bind to them thus allowing for removal of the allergen from a surface.
- both proteases and enzyme inhibitor additives may provide the additional benefit of chemically reacting with the allergen to alter its chemistry and reduce its allergenicity in addition to binding the allergen.
- Cleaners treated in accordance with the present invention provide an economical and effective vehicle for removing numerous allergens from various surfaces to reduce the probability of the allergen causing an allergic response in a host such as a human being.
- the additive-treated cleaners of the present invention are particularly suited for removing numerous allergens from various surfaces.
- allergen is meant to include any antigen that is capable of inducing an allergic reaction in a host such as a human being.
- many common allergens are lipocalins. Lipocalins are a large, diverse group of at least about 50 proteins that serve as transporters from small hydrophobic molecules such as lipids, steroid hormones, bilins, and retenoids. It has been speculated that with regard to animal allergens, lipocalins function biologically as pheromones or pheromone binding proteins.
- Allergens which can be removed from surfaces in accordance with the present invention include, for example, animal allergens such as animal dander and animal saliva, plant allergens such as pollen, fungi, cockroach allergens, and house dust mite allergens including house dust mite feces.
- animal allergens such as animal dander and animal saliva
- plant allergens such as pollen, fungi, cockroach allergens
- house dust mite allergens including house dust mite feces.
- the additive-treated wipes of the present invention are suited for removing allergens associated with domestic and laboratory animals such as dogs, cats, rabbits, mice rats and guinea pigs. More specifically, allergens such as Fel d 1, the most common cat allergen, and Can f 1 and Can f 2, the most common dog allergens can be removed from various surfaces utilizing the wipes of the present invention.
- Various common allergens are further detailed in Table 1.
- the additive-treated wipes of the present invention will remove numerous allergens from various surfaces and the particular listing of allergens herein is merely illustrative and not meant to be in any way limiting.
- the additives comprising a lectin, protease, and/or enzyme inhibitor as described herein are immobilized onto or incorporated into a wipe which is used to form the cleaners of the present invention. Additionally, any one or a combination of the additives could be introduced onto a furniture cover, such as a couch cover, to attract and potentially destroy allergens.
- Suitable wipes for forming the cleaners of the present invention include wet wipes, dry wipes, hand wipes, household wipes, industrial wipes, allergy wipes, and the like.
- conventional wipes have included a single layer of a substantially homogeneous material, but can also comprise a layered material comprised of more than one layer of homogeneous or heterogeneous material.
- wipe substrates Materials suitable for the substrate of the wipes described herein are well known to those skilled in the art, and are typically made from a fibrous sheet material which may be either woven or nonwoven, a knit material, or heavy duty paper.
- the wipes incorporating the additives described herein to remove allergens from a surface may include nonwoven fibrous sheet materials which include meltblown, coform, air-laid, bonded-carded web materials, hydroentangled materials, and combinations thereof. Such materials can be comprised of synthetic or natural fibers, or a combination thereof.
- wipe substrates define a basis weight of from about 25 to about 120 grams per square meter and desirably from about 40 to about 90 grams per square meter.
- the wipe substrate incorporating the additives described herein comprise a coform basesheet of polymeric microfibers and cellulosic fibers having a basis weight of from about 60 to about 80 grams per square meter and desirably about 75 grams per square meter.
- coform basesheets are manufactured generally as described in U.S. Patent No. 4,100,324, which is incorporated by reference.
- coform basesheets comprise a gas- formed matrix of thermoplastic polymeric meltblown microfibers, such as, for example, polypropylene microfibers, and cellulosic fibers, such as, for example, wood pulp fibers.
- the relative percentages of the polymeric microfibers and cellulosic fibers in the coform basesheet can vary over a wide range depending upon the desired characteristics of the wet wipes.
- the coform basesheet may comprise from about 20 to about 100 weight percent, desirably from about 20 to about 60 weight percent, and more desirably from about 30 to about 40 weight percent of the polymeric microfibers based on the dry weight of the coform basesheet being used to provide the wet wipes .
- the wipe substrates can comprise a composite which includes multiple layers of materials.
- the wipe may include a three layer composite which includes an elastomeric film or meltblown layer between two coform layers as described above.
- the coform layers may define a basis weight of from about 15 to about 30 grams per square meter and the elastomeric layer may include a film material such as a polyethylene metallocene film.
- Each wipe is typically rectangular in shape and may have any suitable unfolded width and length. It will be recognized by one skilled in the art, however, that the shape, width, and length of the wipe is not critical to the present invention, and the wipes described herein can be any shape, width, and/or length suitable for the intended application.
- the wipe may have an unfolded length of from about 2.0 to about 80.0 centimeters and desirably from about 10.0 to about 25.0 centimeters and an unfolded width of from about 2.0 to about 80.0 centimeters and desirably from about 10.0 to about 25.0 centimeters.
- each individual wipe is arranged in a folded configuration and stacked one on top of the other to provide a stack of wipes.
- Such folded configurations are well known to those skilled in the art and include c-folded, z-folded, quarter- folded configurations and the like.
- the stack of folded wipes may be placed in the interior of a container, such as a plastic tub, to provide a package of wipes for eventual sale to a consumer.
- the wipes may include a continuous strip of material which has perforations between each wipe and which may be arranged in a stack or wound into a roll for dispensing.
- the above- described wipes have one or more additives incorporated therein or thereon to facilitate the removal of allergens from a surface through the attraction to, or binding of, the allergen with the additive onto the wipe.
- the additive can be applied to the surface of the wipe or can be introduced into the fabric matrix either during or after the formation of the substrate. It is not critical whether the additive is on the surface of the wipe or impregnated into the fibers so long as the additive can contact or come into close proximity with the allergen during the use of the wipe.
- the cleaner comprises a wipe having incorporated thereon or therein a lectin compound for attracting and binding allergens to allow removal of the allergens from a surface.
- a lectin compound for attracting and binding allergens to allow removal of the allergens from a surface.
- the term "lectin” or “lectin compound” is meant to include protein or glycoprotein compounds of plant or animal origin having a molecular weight of from about 60,000 Daltons to about 120,000 Daltons capable of specific recognition of and reversibly binding to, carbohydrate moieties of complex glycoconjugates such as allergens.
- Lectins are also commonly referred to as "phytohemagglutinins” or “phytagglutinins . " Lectins typically chemically bind to sugar moieties of the allergen.
- the lectins used in combination with the cleaners described herein contact the allergen located on a surface as the cleaner is moved across the surface. Upon contacting the allergen, the lectin binds or bonds to one or more carbohydrate or sugar moieties located on the surface structure of the allergen such that the binding or bonding strength between the allergen and the lectin exceeds the forces retaining the allergen on the surface thereby allowing the allergen to be lifted from the surface onto the cleaner for removal.
- the lectins chemically interact substantially with the allergen to cleave numerous bonds to break the allergen into numerous peptides and lead to a significantly different structure or conformation, but simply bond onto the allergen to allow for its removal from the surface.
- the resulting bonding between the allergen and the lectin may be a covalent-type bonding.
- Lectins suitable for use with the cleaners of the present invention include plant or animal lectins capable of binding or bonding to an allergen.
- legume lectins are suitable for use in accordance with the present invention.
- lectins having an affinity for N-acetylgalactosamine (GalNAc) residues are particularly suitable for incorporation into or onto the wipe substrates of the present invention for binding numerous allergens. It is preferred that the lectin be capable of binding or bonding to a lipocalin.
- lectins suitable for use in accordance with the present invention include, but are not limited to, peanut agglutinin, Dolichus biflorus agglutinin, soy bean agglutinin, Lens culinaris agglutinin, Phaseolus agglutinin I, pealectin-I, Ricinus communis agglutinin, Jacalin lectins, Erythrina corallodendron, vicia Villosa, wheat germ agglutinin and combinations thereof.
- Particularly preferred lectins include peanut agglutinin, soybean agglutinin, and Jacalin lectins.
- lectins which are proteins
- lectins can be utilized in combination with the cleaners of the present invention by introducing a lectin- containing protein extract into or onto the wipe comprising the cleaner.
- protein extracts from lectin plant or animal sources can be introduced into or onto the wipes without purifying out the lectin itself from the extract.
- the protein extracts of lectin sources typically contain a sufficiently high concentration of lectin to be highly useful in the present invention.
- soy bean agglutinin can be introduced into a wipe by introducing a soy bean protein extract taken from a soy bean plant directly into or onto the wipe.
- the extract although containing components other than lectins, also contains soybean agglutinin lectins in sufficient amounts as to provide the intended benefits of the present invention.
- plant and animal protein extracts containing lectins may be a highly economical means of implementing the present invention.
- Lectins can be combined with the cleaners in any amount suitable to bind allergens onto the cleaner for removal from a surface.
- Particularly preferred amounts of lectins to be combined with the cleaners are from about 0.00001% (by total weight of the treated cleaner) to about 10% (by total weight of the treated cleaner), more preferably from about 0.00001% (by total weight of the treated cleaner) to about 1% (by total weight of the treated cleaner) , and still more preferably from about 0.00001% (by total weight of the treated cleaner) to about 0.1% (by total weight of the treated cleaner) .
- "by total weight of the treated cleaner” means the weight of the cleaner including the additive.
- the cleaner prior to the addition of the additive would have weighed 9 grams and 1 gram of additive would have been added (1 gram is equal to 10% of the total weight of the cleaner) .
- a protease in another embodiment, can be introduced into or onto cleaner to bind and remove an allergen, such as animal dander, from a surface.
- an allergen such as animal dander
- the term “protease” is meant to include any enzyme that catalyzes the hydrolysis of a protein during the first stage of its degradation to a simpler substance.
- the term “protease” may also be referred to in the art as a “protolytic enzyme” or as a "peptidase.”
- the protease immobilized onto the cleaner will not only attract and bind the allergen to the cleaner to facilitate the removal of the allergen from the surface, but will provide the additional benefit of chemically reacting with the allergen to cleave bonds in the allergen to degrade the allergen into non-allergenic peptides to reduce the allergenicity of the allergen.
- the proteases described herein for immobilization onto the cleaner will chemically interact with the allergen and non-specifically attack and cleave bonds within the allergen structure thus disrupting the overall structure of the allergen and hence its ability to induce an allergic response in a host.
- the protease immobilized into or onto the cleaner will typically bind the allergen onto the cleaner and allow the allergen to therefore be removed from a surface
- the additional advantage of a chemical interaction between the protease and the allergen leading to the cleaving of various bonds and the rendering of the allergen less allergenistic may be important in those cases where the allergen actually removes the immobilized protease from the cleaner to the surface, or where the allergen, after being initially bound onto the cleaner is released back to the surface.
- the allergen even though the allergen remains on the surface and not on the cleaner, the allergen, through chemical cleaving reactions with the protease, will be altered chemically and will be a less potent allergen and less likely to induce an allergic reaction in a host.
- the protease immobilized onto the substrate provides a dual benefit.
- suitable proteases for immobilization onto the cleaner include both include both exopeptidases and endopeptidases .
- the protease immobilized onto the cleaner is capable of chemically interacting with and cleaving bonds non-specifically (that is, at random and not at any specific or pre-determined sites) in lipocalins, a protein family to which numerous important allergen belong.
- suitable proteases include serine proteinases, cysteine proteinases, aspartic proteinases, and metallo proteinases.
- proteases for use in combination with the cleaners discussed herein include chymotrypsin, trypsin, elastase, kallikrein subtilisin, papain, actinidin, bormelain, cathepsins, calpains, pepsin, chymosin, cathepsins, renin, penicillopepsin, rhizopuspepsin, endothiapepsin, thermolysin, neprilysin, aminopeptidase, and astacin.
- proteases include endopeptidases such as bromelain, cathepsin B, cathepsin D, Cathepsin G, chymotrypsin, clostripain, collagenase, dispase, endoproteinase Arg-C, endoproteinase Asp-N, Endoproteinase Glu-C, Endoproteinase Lys-C, Factor Xa, Kallidrein, papain, pepsin, plasmin, proteinase K, subtilisin, thermolysin, thrombin, and trypsin.
- endopeptidases such as bromelain, cathepsin B, cathepsin D, Cathepsin G, chymotrypsin, clostripain, collagenase, dispase, endoproteinase Arg-C, endoproteinase Asp-N, Endoproteinase Glu-C, Endoproteinase Lys
- Endopeptidases as set forth herein are preferred proteases for use in combination with the cleaners disclosed herein because they typically cleave or break apart a protein molecule by cleaving bonds throughout the molecular structure, and in particular in the middle or center of the structure as opposed to simply cleaving or breaking bonds on the ends of the chains. This type of cleaving action results in the protein being broken down into numerous smaller pieces of roughly the same molecular weight.
- exopeptidases which are also useful in the present invention, typically cleave bonds from the ends of molecules and continue cleaving bonds toward the centers of molecules.
- an exopeptidase may break a 2000 unit protein molecule into several individual peptides having an average unit size of a few hundred units
- an exopeptidase cleaving the same protein molecule will produce one peptide structure comprising 1900 units and several other peptides comprising only a few units resulting in less disruption of the allergen protein molecule.
- Proteases can be combined with the cleaners in any amount suitable to bind allergens onto the cleaner to facilitate removal from a surface.
- Particularly preferred amounts of proteases to be combined with the cleaners are from about 0.0001% (by total weight of the treated cleaner) to about 10% (by total weight of the treated cleaner) , more preferably from about 0.0001% (by total weight of the treated cleaner) to about 1% (by total weight of the treated cleaner), and still more preferably from about 0.0001% (by total weight of the treated cleaner) to about 0.1% (by total weight of the treated cleaner) .
- an enzyme inhibitor can be introduced into or onto the cleaner to bind to, and remove allergens, such as animal dander, from a surface.
- allergens such as animal dander
- the term "enzyme inhibitor” is meant to include any compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate- enzyme combination and the resulting catalytic reaction.
- the enzyme inhibitor immobilized onto the cleaner will not only bind onto allergens and remove them from a surface, but will also provide the additional benefit of chemically reacting with the allergen, or an enzyme required for the allergen to be allergenistic, to reduce the allergenicity of the allergen.
- the enzyme inhibitor interacts with the enzyme required by the allergen to be allergenistic and prevents the normal substrate-enzyme catalytic reaction from occurring such that the allergenicity of the allergen is significantly reduced or eliminated.
- allergens can exist chemically as proteins and/or as enzymes.
- an allergen is a protein, it may require the enzymatic activity of a enzyme to render the allergen allergenistic, or at least to increase the level of allergenicity of the allergen.
- an allergen may exist as a long chain protein which, by itself, because of its structure and chain size could not significantly penetrate the skin or mucosa membranes of a host and, therefore, would be expected to typically have a low allergenicity by itself.
- this type of protein allergen structure becomes significantly more allergenistic when a specific protease enzyme interacts with the allergen to cleave the allergen at one or more specific bonding sites into smaller, allergenistically active, peptide fragments which can penetrate the skin or mucosa membrane of a host and lead to an allergic reaction.
- an enzyme inhibitor By introducing an enzyme inhibitor into or onto the cleaner and contacting the allergen and protease enzyme with the impregnated cleaner, the enzyme inhibitor will significantly reduce or inhibit the enzymatic activity of the protease enzyme resulting in a disruption of the enzyme-substrate interaction and a decrease in allergenicity.
- allergens may themselves exist as enzymes.
- the allergen can interact with itself to cleave specific bonds or otherwise chemically alter its structure to reduce the overall size or change the conformation of the allergen to allow penetration into skin or mucosa membrane openings.
- the allergen typically does not require an external protease enzyme to chemically alter its size or conformation to become allergenistic.
- an enzyme inhibitor By contacting the allergen, which exists as an enzyme, with an enzyme inhibitor, the allergenicity of the allergen is significantly reduced as the allergen cannot be specifically cleaved into smaller fragments or its conformation changed to allow for penetration into a host.
- the enzyme inhibitors immobilized onto the cleaners as set forth herein will bind both protein-type and enzyme-type allergens onto the substrate allowing them to be removed from a surface upon contacting the wipe.
- enzyme-type allergens it is believed that the enzyme inhibitor is attracted to the enzyme-type allergen and a chemical interaction occurs whereby the enzymatic activity of the allergen is reduced; that is, a chemical interaction occurs wherein attraction and/or binding between the allergen and the enzyme inhibitor occurs allowing for the allergen to be attracted to and retained in the substrate of the wipe and removed from a surface.
- the enzyme inhibitor chemically interacts with the required protease enzyme which may be in chemical contact with the protein and allow for attraction and binding of the entire complex onto the cleaner.
- the enzyme inhibitors described herein will attract and bind for removal both enzyme-type allergens and protein-type allergen, it is further believed that the enzyme inhibitors are more likely to bind and retain enzyme-type allergens .
- the enzyme inhibitor immobilized onto the cleaner will typically bind an allergen onto the cleaner and allow the allergen to therefore be removed from a surface
- the additional advantage of having the enzyme inhibitor inhibit the enzymatic activity of the enzyme may be important in those cases where the allergen actually removes the immobilized enzyme inhibitor from the cleaner to the surface, or where the allergen, after being initially bound onto the cleaner is released back to the surface.
- the allergen even though the allergen remains on the surface and not on the cleaner, the allergen, through the interaction with the enzyme inhibitor, may be a less potent allergen and less likely to induce an allergic reaction in a host.
- the enzyme inhibitors immobilized onto the web provide a dual benefit.
- suitable enzyme inhibitors for immobilization on the cleaners of the present invention include, but are not limited to, Amastatin, Antipain, Actinonin, Aprotinin, APMSF, Bestatin, Benzamidine, Chymostatin, 3 , 4-dichloroisocoumarin, DFP, E-64, Elastatinal, Leupeptin, Pepstatin, 1,10- Phenanthroline, Phosphoramidon, TLCK, and TPCK.
- Enzyme inhibitors can be combined with the wipe substrate in any amount suitable to bind allergens onto the cleaner to facilitate removal from a surface.
- Particularly preferred amounts of enzyme inhibitors to be combined with the cleaners are from about 0.0001% (by total weight of the treated cleaner) to about 10% (by total weight of the treated cleaner), more preferably from about 0.0001% (by total weight of the treated cleaner) to about 1% (by total weight of the treated cleaner) , and still more preferably from about 0.0001% (by total weight of the treated cleaner) to about 0.1% (by total weight of the treated cleaner).
- the cleaners described herein can have immobilized thereon or therein a combination of lectins, proteases and/or enzyme inhibitors to attract, bind and potentially reduce the allergenicity of, various allergens.
- the cleaner comprises a combination of lectins and proteases or a combination of lectins and enzyme inhibitors. Because it is believed that lectins simply attract and bind the allergen to the cleaner but do not significantly reduce the allergenicity of the allergen, it may be preferable to impregnate the cleaner with a protease and/or an enzyme inhibitor in addition to the lectin to act upon the bound allergen (or required enzyme) on the cleaner to ultimately reduce its allergenicity.
- the protease or the enzyme inhibitor can chemically interact with the allergen to reduce its allergenicity on the substrate's surface. This may be important should the allergen be dislodged from the cleaner.
- the lectin is typically present in an amount of from about 0.0001% (by total weight of the treated cleaner) to about 10% (by total weight of the treated cleaner), more preferably from about 0.0001% (by total weight of the treated cleaner) to about 1% (by total weight of the treated cleaner) , and still more preferably from about 0.0001% (by total weight of the treated cleaner) to about 0.1% (by total weight of the treated cleaner).
- the protease When proteases are used in combination with lectins, the protease is typically present in an amount of from about 0.0001% (by total weight of the treated cleaner) to about 10% (by total weight of the treated cleaner) , more preferably from about 0.0001% (by total weight of the treated cleaner) to about 1% (by total weight of the treated cleaner) , and still more preferably from about 0.0001% (by total weight of the treated cleaner) to about 0.1% (by total weight of the treated cleaner) .
- the enzyme inhibitors are used in combination with lectins, the enzyme inhibitor is typically present in an amount of from about 0.0001% (by total weight of the treated cleaner) to about 10% (by total weight of the treated cleaner) , more preferably from about 0.0001% (by total weight of the treated cleaner) to about 1% (by total weight of the treated cleaner) , and still more preferably from about 0.0001% (by total weight of the treated cleaner) to about 0.1% (by total weight of the treated cleaner) .
- the additives described herein can be immobilized or impregnated onto the surface of the cleaner by any means capable of stabilizing the additive on or near the cleaner's surface including, for example, printing, particle impingement and/or through the manipulation of electrostatic forces.
- the additive (s) is introduced onto or into a gas permeable cleaner in accordance with the present invention through the use of a vacuum driving force or through the use of a pressure differential.
- a vacuum driving force When utilizing a vacuum force, the additive (s) is positioned on the cleaner while a vacuum driving force is applied to the opposite side of the cleaner to drive the additive into the fabric matrix of the cleaner.
- Varying degrees of vacuum can be applied depending upon the required depth of the additive, and it is typically preferred that the additives remain at or near the surface of the cleaner for maximum effectiveness.
- the additive-containing cleaners of the present invention can be utilized to remove allergens such as animal dander from a variety of surfaces including, for example, human skin, animal skin, human hair, animal hair, tabletops, countertops, electronic boards, and other hard or soft surfaces where allergens are problematic.
- the additive- containing cleaners described herein are particularly useful in removing animal or pet dander, such as cat or dog dander, from various surfaces in the home or office.
- the additives can be immobilized on a cleaner to be used as a wet wipe or as a dry wipe.
- the wipe substrate When a wet wipe is utilized, the wipe substrate will be in direct contact with a liquid, or wetting agent.
- the liquid formulation is not critical to the present invention with the exception that the components of the liquid portion of the wet wipe should not be substantially antagonistic to the additive (s) introduced onto the wipe substrate and cleaner.
- the liquid can typically be any solution which can be absorbed into the wet wipe substrate and may include any suitable components which provide the desired wiping properties.
- the components may include water, alcohol, emollients, surfactants, fragrances, preservatives, chelating agents, pH buffers or combinations thereof as are well known to those skilled in the art.
- the liquid may contain lotions and/or medicaments.
- the additives described herein can be introduced into the liquid component of a wet wipe system and be used in combination with a wet wipe substrate.
- the additive is contained in the liquid component of the wet wipe system and, as such, may be retained on the surface being cleaned after wiping instead of being removed by the substrate.
- this embodiment is useful in some applications.
- the wet wipe solution comprises a lectin
- the lectin may bind onto the allergen located on the surface and may thus inhibit the bound allergen from entering host and causing an allergic response because the combination of the lectin and the allergen it too large to effectively enter a host.
- the allergen may be effectively neutralized and may not be capable of inducing an allergic reaction even if introduced into the host.
- the additives described herein could also be introduced into a cleansing cream or lotion meant to be used to clean human and animal skin or hair. Similar to the additives in the wet wipe solutions described above, the additives in the cleansing cream or lotion may remain on the skin or hair, but could still provide significant benefits relating to the reduction of allergic responses.
- each wet wipe may vary depending upon the type of material being used to provide the wet wipe, the type of liquid being used, the type of container being used to store the wet wipes, and the desired end use of the wet wipe.
- each wet wipe can contain from about 150 to about 600 weight percent and desirably from about 250 to about 450 weight percent liquid based on the dry weight of the wipe for improved wiping.
- the amount o of liquid contained within the wet wipe is from about 300 to about 400 weight percent and desirably about 330 weight percent based on the dry weight of the wet wipe. If the amount of liquid is less than the above-identified ranges, the wet wipe may be too dry and may not adequately perform. If the amount of liquid is greater than the above-identified ranges, the wet wipe may be oversaturated and soggy and the liquid may pool in the bottom of the container.
- Example 1 In this Example, various lectins were evaluated to determine whether the lectin exhibited a binding affinity for feline dander, a glycoprotein, at various feline dander concentrations.
- Cat hair was obtained from two felines via routing grooming. Approximately 0.5 grams of fur from each cat was placed into the same 50 mL conical tube with 15 mL of Phosphate Buffered Saline (PBS) . The tube was placed on a rocker overnight. The following day, the extracted dander was analyzed using the fel d 1 ELISA procedure referenced below. The extracted dander was tested neat, 1:10, 1:100, 1:1000, 1:10,000, 1:100,000, and 1:1,000,000. The dilutions were prepared in PBS . The concentration of the extracted dander in the phosphate buffered saline solution was determined using a monoclonal Fel d 1 ELISA kit (Indoor Biotechnologies, Charlottesville, Va . ) .
- PBS Phosphate Buffered Saline
- lectins (bead bound, from Sigma Chemical St. Louis, Mo) were evaluated for their ability to bind feline dander: Concanavalin A, Jacalin, Peanut, Soybean, and UEA. Each lectin was separately introduced into 0.1 M Phosphate Buffered Saline (PBS) to produce a 0.4 milligram/milliliters solution of lectin in PBS. 500 microliters of the 0.4 milligram/milliliter lectin solution was introduced into a microcentrifuge tube. To the tube was added feline dander (500 microliters of either 3.4 microgram/milliliter dander in PBS or 37 micrograms/milliliter dander in PBS, depending on the experiment) .
- PBS Phosphate Buffered Saline
- the lectin/dander mixture was vortexed for 1 hour at room temperature to thoroughly mix the dander and lectin. Upon completion of the mixing, the lectin bound dander and free dander were separated by centrifugation (13,000 rpm for 5 minutes). The amount of free dander in the resulting supernate was determined using the Fel d 1 ELISA method referenced above. The amount of dander bound by the lectin is described by the ratio of the amount of free dander in lectin treated samples to the amount of free dander in control samples not exposed to the lectin.
- Jacalin, Peanut, and Soybean lectin all removed at least 50% of the added feline dander. Also, increasing the concentration of dander by about 10 fold did not appear to reduce the binding affinity of the Jacalin, Peanut, and Soybean lectins. Also, at the higher concentration, the Jacalin and Peanut (Soybean not tested at higher concentration) removed at least 90% of the dander in solution. Jacalin, Peanut, and Soybean lectins each have a residue affinity for N-acetyl-D-galactosamine while both Concanavalin A and UEA do not. This indicates that lectins having a residue affinity for N-acetyl-D-galactosamine are good candidates for dander binding.
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Cleaning Implements For Floors, Carpets, Furniture, Walls, And The Like (AREA)
- Detergent Compositions (AREA)
- Cosmetics (AREA)
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004521447A JP2005532463A (en) | 2002-07-10 | 2003-05-23 | Detergents for control and removal of allergens |
AU2003231836A AU2003231836B2 (en) | 2002-07-10 | 2003-05-23 | Cleaners for the control and removal of allergens |
BR0312565-3A BR0312565A (en) | 2002-07-10 | 2003-05-23 | Wipers for the control and removal of allergens from various surfaces and method for removing them |
MXPA05000109A MXPA05000109A (en) | 2002-07-10 | 2003-05-23 | Cleaners for the control and removal of allergens. |
EP03764300A EP1520005B1 (en) | 2002-07-10 | 2003-05-23 | Cleaners for the control and removal of allergens |
DE60316292T DE60316292T2 (en) | 2002-07-10 | 2003-05-23 | CLEANING AGENT FOR CONTROLLING AND REMOVING ALLERGENIC |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/192,053 US20040007251A1 (en) | 2002-07-10 | 2002-07-10 | Cleaners for the control and removal of allergens |
US10/192,053 | 2002-07-10 |
Publications (2)
Publication Number | Publication Date |
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WO2004007658A2 true WO2004007658A2 (en) | 2004-01-22 |
WO2004007658A3 WO2004007658A3 (en) | 2004-06-10 |
Family
ID=30114264
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/016398 WO2004007658A2 (en) | 2002-07-10 | 2003-05-23 | Cleaners for the control and removal of allergens |
Country Status (9)
Country | Link |
---|---|
US (2) | US20040007251A1 (en) |
EP (1) | EP1520005B1 (en) |
JP (1) | JP2005532463A (en) |
KR (1) | KR20050025323A (en) |
AU (2) | AU2003231836B2 (en) |
BR (1) | BR0312565A (en) |
DE (1) | DE60316292T2 (en) |
MX (1) | MXPA05000109A (en) |
WO (1) | WO2004007658A2 (en) |
Cited By (7)
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JP2006143700A (en) * | 2004-10-18 | 2006-06-08 | Maruzen Pharmaceut Co Ltd | Allergen inactivator and allergen inactivating substance |
JP2011225627A (en) * | 2004-10-18 | 2011-11-10 | Maruzen Pharmaceut Co Ltd | Allergen deactivating agent, and allergen deactivating material |
US8153635B2 (en) | 2007-09-20 | 2012-04-10 | Irm Llc | Compounds and compositions as modulators of GPR119 activity |
DE102012219954A1 (en) | 2012-10-31 | 2014-04-30 | Henkel Ag & Co. Kgaa | Polymers for allergen-repulsive equipment |
DE102012219948A1 (en) | 2012-10-31 | 2014-04-30 | Henkel Ag & Co. Kgaa | Polymers for allergen-adhesive equipment |
WO2015092663A1 (en) * | 2013-12-19 | 2015-06-25 | Nestec Sa | Compositions and methods for reducing cat allergens in the environment |
WO2016123311A1 (en) * | 2015-01-28 | 2016-08-04 | North Carolina Agricultural And Technical State University | Enzymatic treatment of peanuts |
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US7527783B2 (en) * | 2004-03-23 | 2009-05-05 | The Clorox Company | Methods for deactivating allergens and preventing disease |
US20060034952A1 (en) * | 2004-08-13 | 2006-02-16 | Kondhalkar Mrinmayee B | Agent for inhibiting the growth of mammalian hair |
US20070037721A1 (en) * | 2004-09-01 | 2007-02-15 | The Procter & Gamble Company | Moistened disposable wipe for controlling allergens |
WO2006028273A1 (en) * | 2004-09-09 | 2006-03-16 | Uni-Charm Corporation | Cleaning implement |
CN100577082C (en) * | 2004-09-09 | 2010-01-06 | 尤妮佳股份有限公司 | Cleaning implement |
WO2006028280A1 (en) * | 2004-09-09 | 2006-03-16 | Uni-Charm Corporation | Cleaning implement |
JP4822704B2 (en) * | 2004-12-28 | 2011-11-24 | ユニ・チャーム株式会社 | Cleaning tool |
ATE521370T1 (en) * | 2005-07-12 | 2011-09-15 | Stepan Co | COMPOSITION AND METHOD FOR DEACTIVATION OF ALLERGENIC PROTEINS ON SURFACES |
US9603781B2 (en) | 2012-09-07 | 2017-03-28 | Coviden Lp | Skin cleaning kit |
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- 2003-05-23 EP EP03764300A patent/EP1520005B1/en not_active Expired - Fee Related
- 2003-05-23 AU AU2003231836A patent/AU2003231836B2/en not_active Ceased
- 2003-05-23 WO PCT/US2003/016398 patent/WO2004007658A2/en active IP Right Grant
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- 2003-05-23 MX MXPA05000109A patent/MXPA05000109A/en active IP Right Grant
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Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2006143700A (en) * | 2004-10-18 | 2006-06-08 | Maruzen Pharmaceut Co Ltd | Allergen inactivator and allergen inactivating substance |
JP2011225627A (en) * | 2004-10-18 | 2011-11-10 | Maruzen Pharmaceut Co Ltd | Allergen deactivating agent, and allergen deactivating material |
US8153635B2 (en) | 2007-09-20 | 2012-04-10 | Irm Llc | Compounds and compositions as modulators of GPR119 activity |
DE102012219954A1 (en) | 2012-10-31 | 2014-04-30 | Henkel Ag & Co. Kgaa | Polymers for allergen-repulsive equipment |
DE102012219948A1 (en) | 2012-10-31 | 2014-04-30 | Henkel Ag & Co. Kgaa | Polymers for allergen-adhesive equipment |
EP2727985A2 (en) | 2012-10-31 | 2014-05-07 | Henkel AG & Co. KGaA | Polymers for allergen repulsive equipment |
EP2727986A2 (en) | 2012-10-31 | 2014-05-07 | Henkel AG & Co. KGaA | Polymers for allergen adhesive equipment |
WO2015092663A1 (en) * | 2013-12-19 | 2015-06-25 | Nestec Sa | Compositions and methods for reducing cat allergens in the environment |
US10889785B2 (en) | 2013-12-19 | 2021-01-12 | Société des Produits Nestlé S.A. | Compositions and methods for reducing cat allergens in the environment |
WO2016123311A1 (en) * | 2015-01-28 | 2016-08-04 | North Carolina Agricultural And Technical State University | Enzymatic treatment of peanuts |
Also Published As
Publication number | Publication date |
---|---|
US20040007251A1 (en) | 2004-01-15 |
JP2005532463A (en) | 2005-10-27 |
US20080244853A1 (en) | 2008-10-09 |
KR20050025323A (en) | 2005-03-14 |
WO2004007658A3 (en) | 2004-06-10 |
EP1520005B1 (en) | 2007-09-12 |
AU2003231836A1 (en) | 2004-02-02 |
BR0312565A (en) | 2005-10-18 |
EP1520005A2 (en) | 2005-04-06 |
DE60316292D1 (en) | 2007-10-25 |
AU2008237615A1 (en) | 2008-11-27 |
AU2003231836B2 (en) | 2008-08-21 |
DE60316292T2 (en) | 2008-06-12 |
MXPA05000109A (en) | 2005-04-08 |
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