WO2003041496A1 - Animal transgenique - Google Patents
Animal transgenique Download PDFInfo
- Publication number
- WO2003041496A1 WO2003041496A1 PCT/JP2002/011843 JP0211843W WO03041496A1 WO 2003041496 A1 WO2003041496 A1 WO 2003041496A1 JP 0211843 W JP0211843 W JP 0211843W WO 03041496 A1 WO03041496 A1 WO 03041496A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- substance
- memory
- screening
- learning
- improving learning
- Prior art date
Links
- 230000009261 transgenic effect Effects 0.000 title 1
- 239000000126 substance Substances 0.000 abstract 6
- 238000000034 method Methods 0.000 abstract 4
- 238000012216 screening Methods 0.000 abstract 4
- 208000019901 Anxiety disease Diseases 0.000 abstract 2
- 230000002205 anti-dementic effect Effects 0.000 abstract 2
- 230000036506 anxiety Effects 0.000 abstract 2
- 238000001727 in vivo Methods 0.000 abstract 2
- 206010012289 Dementia Diseases 0.000 abstract 1
- 102000004257 Potassium Channel Human genes 0.000 abstract 1
- 102100025072 Potassium voltage-gated channel subfamily H member 3 Human genes 0.000 abstract 1
- 101710163355 Potassium voltage-gated channel subfamily H member 3 Proteins 0.000 abstract 1
- 230000001133 acceleration Effects 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000000049 anti-anxiety effect Effects 0.000 abstract 1
- 239000002249 anxiolytic agent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000002018 overexpression Effects 0.000 abstract 1
- 108020001213 potassium channel Proteins 0.000 abstract 1
- 238000011830 transgenic mouse model Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Environmental Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002465337A CA2465337A1 (en) | 2001-11-14 | 2002-11-13 | Transgenic animal |
US10/493,943 US7094948B2 (en) | 2001-11-14 | 2002-11-13 | Transgenic animals |
JP2003543396A JP3679403B2 (ja) | 2001-11-14 | 2002-11-13 | トランスジェニック動物 |
EP02781760A EP1444889A4 (en) | 2001-11-14 | 2002-11-13 | TRANSGENE ANIMAL |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001349288 | 2001-11-14 | ||
JP2001-349288 | 2001-11-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003041496A1 true WO2003041496A1 (fr) | 2003-05-22 |
Family
ID=19161979
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2002/011843 WO2003041496A1 (fr) | 2001-11-14 | 2002-11-13 | Animal transgenique |
Country Status (5)
Country | Link |
---|---|
US (1) | US7094948B2 (ja) |
EP (1) | EP1444889A4 (ja) |
JP (1) | JP3679403B2 (ja) |
CA (1) | CA2465337A1 (ja) |
WO (1) | WO2003041496A1 (ja) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4325402B2 (ja) * | 2002-02-05 | 2009-09-02 | アステラス製薬株式会社 | 2,4,6−トリアミノ−1,3,5−トリアジン誘導体 |
US20090093403A1 (en) | 2007-03-01 | 2009-04-09 | Feng Zhang | Systems, methods and compositions for optical stimulation of target cells |
US8926959B2 (en) | 2005-07-22 | 2015-01-06 | The Board Of Trustees Of The Leland Stanford Junior University | System for optical stimulation of target cells |
JP2009502140A (ja) | 2005-07-22 | 2009-01-29 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 光活性化陽イオンチャネルおよびその使用 |
US9274099B2 (en) | 2005-07-22 | 2016-03-01 | The Board Of Trustees Of The Leland Stanford Junior University | Screening test drugs to identify their effects on cell membrane voltage-gated ion channel |
US10052497B2 (en) | 2005-07-22 | 2018-08-21 | The Board Of Trustees Of The Leland Stanford Junior University | System for optical stimulation of target cells |
US9238150B2 (en) | 2005-07-22 | 2016-01-19 | The Board Of Trustees Of The Leland Stanford Junior University | Optical tissue interface method and apparatus for stimulating cells |
DE102006021257A1 (de) * | 2006-04-28 | 2007-11-08 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Nachweis von transgener DNA (t DNA) |
US8398692B2 (en) | 2007-01-10 | 2013-03-19 | The Board Of Trustees Of The Leland Stanford Junior University | System for optical stimulation of target cells |
US10035027B2 (en) | 2007-10-31 | 2018-07-31 | The Board Of Trustees Of The Leland Stanford Junior University | Device and method for ultrasonic neuromodulation via stereotactic frame based technique |
US10434327B2 (en) | 2007-10-31 | 2019-10-08 | The Board Of Trustees Of The Leland Stanford Junior University | Implantable optical stimulators |
WO2009131837A2 (en) | 2008-04-23 | 2009-10-29 | The Board Of Trustees Of The Leland Stanford Junior University. | Systems, methods and compositions for optical stimulation of target cells |
SG191604A1 (en) | 2008-06-17 | 2013-07-31 | Univ Leland Stanford Junior | Apparatus and methods for controlling cellular development |
WO2010006049A1 (en) | 2008-07-08 | 2010-01-14 | The Board Of Trustees Of The Leland Stanford Junior University | Materials and approaches for optical stimulation of the peripheral nervous system |
NZ602416A (en) | 2008-11-14 | 2014-08-29 | Univ Leland Stanford Junior | Optically-based stimulation of target cells and modifications thereto |
KR101036338B1 (ko) | 2009-03-27 | 2011-05-23 | 경상대학교산학협력단 | Tresk 유전자를 과발현하는 형질전환 동물 및 이의 제조방법 |
US8399663B2 (en) * | 2009-04-03 | 2013-03-19 | Astellas Pharma Inc. | Salt of 1,3,5-triazine-2,4,6-triamine derivative |
US20120088772A1 (en) | 2009-05-29 | 2012-04-12 | Astellas Pharma Inc. | Novel pharmaceutical composition for prevention and/or treatment of attention deficit/hyperactivity disorder |
CN105941328B (zh) | 2010-11-05 | 2019-04-09 | 斯坦福大学托管董事会 | 一种鉴定抑制前额叶皮质中的兴奋性或抑制性神经元的去极化的化合物的*** |
US8932562B2 (en) | 2010-11-05 | 2015-01-13 | The Board Of Trustees Of The Leland Stanford Junior University | Optically controlled CNS dysfunction |
WO2012061681A1 (en) | 2010-11-05 | 2012-05-10 | The Board Of Trustees Of The Leland Stanford Junior University. | Control and characterization of memory function |
AU2011323226B2 (en) | 2010-11-05 | 2015-03-12 | The Board Of Trustees Of The Leland Stanford Junior University | Light-activated chimeric opsins and methods of using the same |
CN110215614A (zh) | 2010-11-05 | 2019-09-10 | 斯坦福大学托管董事会 | 用于光遗传学方法的光的上转换 |
CN103476456B (zh) | 2010-11-05 | 2017-10-03 | 斯坦福大学托管董事会 | 奖赏相关行为的光遗传学控制 |
US8696722B2 (en) | 2010-11-22 | 2014-04-15 | The Board Of Trustees Of The Leland Stanford Junior University | Optogenetic magnetic resonance imaging |
CA2859364C (en) | 2011-12-16 | 2019-05-07 | The Board Of Trustees Of The Leland Stanford Junior University | Opsin polypeptides and methods of use thereof |
ES2728077T3 (es) | 2012-02-21 | 2019-10-22 | Univ Leland Stanford Junior | Composiciones para el tratamiento de trastornos neurogénicos del suelo pélvico |
CA2906756A1 (en) | 2013-03-15 | 2014-09-18 | The Board Of Trustees Of The Leland Stanford Junior University | Optogenetic control of behavioral state |
EP2991491B1 (en) | 2013-04-29 | 2019-12-25 | The Board of Trustees of the Leland Stanford Junior University | Devices, systems and methods for optogenetic modulation of action potentials in target cells |
WO2015023782A1 (en) | 2013-08-14 | 2015-02-19 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for controlling pain |
US10568516B2 (en) | 2015-06-22 | 2020-02-25 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and devices for imaging and/or optogenetic control of light-responsive neurons |
US11294165B2 (en) | 2017-03-30 | 2022-04-05 | The Board Of Trustees Of The Leland Stanford Junior University | Modular, electro-optical device for increasing the imaging field of view using time-sequential capture |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999027677A1 (en) * | 1997-11-26 | 1999-06-03 | V-One Corporation | Session key recovery system and method |
WO1999043696A1 (en) * | 1998-02-25 | 1999-09-02 | Icagen Inc. | Human potassium channel genes |
WO2000005346A1 (en) * | 1998-07-21 | 2000-02-03 | Millennium Pharmaceuticals, Inc. | Novel potassium channel molecules and uses therefor |
WO2000009534A1 (en) * | 1998-08-14 | 2000-02-24 | Elan Pharmaceuticals, Inc. | Novel esk potassium channel polypeptide and polynucleotide compositions |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU1982799A (en) * | 1998-01-23 | 1999-08-09 | Yamanouchi Pharmaceutical Co., Ltd. | Novel potassium channel protein |
US6413741B1 (en) | 1998-07-01 | 2002-07-02 | Icagen, Incorporated | Human elk a voltage-gated potassium channel subunit |
FR2781979B1 (fr) * | 1998-08-05 | 2001-06-08 | Fond Jean Dausset Ceph | Modele animal presentant une deficience de la memoire et/ou des troubles comportementaux |
EP1002863A1 (en) | 1998-10-13 | 2000-05-24 | Sanofi-Synthelabo | A potassium channel member of the erg family |
CA2457819A1 (en) | 2001-08-14 | 2003-02-27 | The General Hospital Corporation | Nucleic acid and amino acid sequences involved in pain |
-
2002
- 2002-11-13 US US10/493,943 patent/US7094948B2/en not_active Expired - Fee Related
- 2002-11-13 CA CA002465337A patent/CA2465337A1/en not_active Abandoned
- 2002-11-13 EP EP02781760A patent/EP1444889A4/en not_active Withdrawn
- 2002-11-13 WO PCT/JP2002/011843 patent/WO2003041496A1/ja active Application Filing
- 2002-11-13 JP JP2003543396A patent/JP3679403B2/ja not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999027677A1 (en) * | 1997-11-26 | 1999-06-03 | V-One Corporation | Session key recovery system and method |
WO1999043696A1 (en) * | 1998-02-25 | 1999-09-02 | Icagen Inc. | Human potassium channel genes |
WO2000005346A1 (en) * | 1998-07-21 | 2000-02-03 | Millennium Pharmaceuticals, Inc. | Novel potassium channel molecules and uses therefor |
WO2000009534A1 (en) * | 1998-08-14 | 2000-02-24 | Elan Pharmaceuticals, Inc. | Novel esk potassium channel polypeptide and polynucleotide compositions |
Non-Patent Citations (2)
Title |
---|
MAYFORD M. ET AL: "The 3'-untranslated region of CaMKIIalpha is a cis-acting signal for the localization and translation of mRNA in dendrites", PROC. NATL. ACAD. SCI. USA, vol. 93, 27 August 1996 (1996-08-27), pages 13250 - 13255, XP002918895 * |
See also references of EP1444889A4 * |
Also Published As
Publication number | Publication date |
---|---|
US20040210952A1 (en) | 2004-10-21 |
EP1444889A1 (en) | 2004-08-11 |
US7094948B2 (en) | 2006-08-22 |
CA2465337A1 (en) | 2003-05-22 |
JP3679403B2 (ja) | 2005-08-03 |
JPWO2003041496A1 (ja) | 2005-03-03 |
EP1444889A4 (en) | 2006-10-04 |
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