WO2002067239A3 - Process for preparing intermediates of hiv protease inhibitors - Google Patents

Process for preparing intermediates of hiv protease inhibitors Download PDF

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Publication number
WO2002067239A3
WO2002067239A3 PCT/US2001/051428 US0151428W WO02067239A3 WO 2002067239 A3 WO2002067239 A3 WO 2002067239A3 US 0151428 W US0151428 W US 0151428W WO 02067239 A3 WO02067239 A3 WO 02067239A3
Authority
WO
WIPO (PCT)
Prior art keywords
protease inhibitors
hiv protease
preparing intermediates
intermediates
preparing
Prior art date
Application number
PCT/US2001/051428
Other languages
French (fr)
Other versions
WO2002067239A2 (en
Inventor
Roman Davis
Thomas Claiborne Lovelace
Original Assignee
Glaxo Group Ltd
Roman Davis
Thomas Claiborne Lovelace
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd, Roman Davis, Thomas Claiborne Lovelace filed Critical Glaxo Group Ltd
Priority to EP01271082A priority Critical patent/EP1404680A2/en
Priority to AU2002255473A priority patent/AU2002255473A1/en
Priority to US10/399,809 priority patent/US20040026230A1/en
Priority to JP2002566479A priority patent/JP2004519473A/en
Publication of WO2002067239A2 publication Critical patent/WO2002067239A2/en
Publication of WO2002067239A3 publication Critical patent/WO2002067239A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

The invention describes a method for effecting intramolecular cyclization reactions using light, in the absence of radical initiators, to provide useful polycyclic compounds.
PCT/US2001/051428 2000-10-24 2001-10-22 Process for preparing intermediates of hiv protease inhibitors WO2002067239A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP01271082A EP1404680A2 (en) 2000-10-24 2001-10-22 Process for preparing intermediates of hiv protease inhibitors
AU2002255473A AU2002255473A1 (en) 2000-10-24 2001-10-22 Process for preparing intermediates of hiv protease inhibitors
US10/399,809 US20040026230A1 (en) 2001-10-22 2001-10-22 Process for preparing intermediates of hiv protease inhibitors
JP2002566479A JP2004519473A (en) 2000-10-24 2001-10-22 Method for producing intermediate of HIV protease inhibitor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24282200P 2000-10-24 2000-10-24
US60/242,822 2000-10-24

Publications (2)

Publication Number Publication Date
WO2002067239A2 WO2002067239A2 (en) 2002-08-29
WO2002067239A3 true WO2002067239A3 (en) 2004-01-08

Family

ID=22916319

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2001/046116 WO2002060905A2 (en) 2000-10-24 2001-10-22 Process for preparing intermediates of hiv protease inhibitors
PCT/US2001/051428 WO2002067239A2 (en) 2000-10-24 2001-10-22 Process for preparing intermediates of hiv protease inhibitors

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2001/046116 WO2002060905A2 (en) 2000-10-24 2001-10-22 Process for preparing intermediates of hiv protease inhibitors

Country Status (4)

Country Link
EP (1) EP1404680A2 (en)
JP (1) JP2004519473A (en)
AU (1) AU2002255473A1 (en)
WO (2) WO2002060905A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003247651A1 (en) * 2002-06-27 2004-01-19 Smithkline Beecham Corporation PREPARATION OF STEREOISOMERS OF (3ALPHA, 3ALPHA/BETA, 6ALPHA/BETA) HEXAHYDROFURO(2,3-b)FURAN-3-OL
ES2572001T3 (en) 2006-03-29 2016-05-27 Gilead Sciences Inc Derived from antiviral bisfuran as an HIV protease inhibitor and intermediates thereof
RS51675B (en) 2006-11-09 2011-10-31 Tibotec Pharmaceuticals Methods for the preparation of hexahydrofuro[2,3-b]furan-3-ol
CN103864813B (en) * 2012-12-18 2017-02-22 上海迪赛诺化学制药有限公司 Synthetic methods of hexahydrofuro[2,3-b]furan-3-ol and enantiomer thereof
CN107607635B (en) * 2017-08-15 2020-07-31 东北制药集团股份有限公司 Method for detecting content of propiolic alcohol in levophosphamide salt by adopting headspace gas chromatography
CR20220316A (en) 2019-12-06 2022-10-07 Vertex Pharma Substituted tetrahydrofurans as modulators of sodium channels
WO2022256622A1 (en) 2021-06-04 2022-12-08 Vertex Pharmaceuticals Incorporated N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHIN-KANG SHA ET AL.: "Radical Cyclization of alpha-Iodo Enones by Photoinduced Electron Transfer Reaction", CHEM. COMMUN., 1998, pages 397 - 8, XP002214198 *
COSSY J ET AL: "An Approach to the Skeleton of Eriolanin", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 36, no. 12, 20 March 1995 (1995-03-20), pages 2067 - 2070, XP004028406, ISSN: 0040-4039 *
DULCÈRE, J.-P. ET AL.: "New Triethylamine induced Carbocycliation of beta-Bromopropargyl Ethers in the Pyrimidinedione Series", SYNLETT, 1995, pages 705 - 6, XP002214199 *
JANINE COSSY ET AL.: "Formation of Radicals by Irradiation of Alkyl Halides in the Presence of Triethylamine", TETRAHEDRON LETTERS, ELEVIER SCIENCE PUBLISHERS, AMSTERDAN, NL, vol. 35, no. 44, 1994, pages 8161 - 2, XP002214197 *

Also Published As

Publication number Publication date
WO2002067239A2 (en) 2002-08-29
JP2004519473A (en) 2004-07-02
WO2002060905A2 (en) 2002-08-08
EP1404680A2 (en) 2004-04-07
AU2002255473A1 (en) 2002-09-04

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