WO2002022611A3 - Caspase inhibitors and uses thereof - Google Patents

Caspase inhibitors and uses thereof Download PDF

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Publication number
WO2002022611A3
WO2002022611A3 PCT/US2001/028450 US0128450W WO0222611A3 WO 2002022611 A3 WO2002022611 A3 WO 2002022611A3 US 0128450 W US0128450 W US 0128450W WO 0222611 A3 WO0222611 A3 WO 0222611A3
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Prior art keywords
group
optionally substituted
ring
hydrogen
caspase inhibitors
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PCT/US2001/028450
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French (fr)
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WO2002022611A2 (en
Inventor
Jean-Damien Charrier
Ronald Knegtel
Michael Mortimore
Original Assignee
Vertex Pharma
Jean-Damien Charrier
Ronald Knegtel
Michael Mortimore
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Application filed by Vertex Pharma, Jean-Damien Charrier, Ronald Knegtel, Michael Mortimore filed Critical Vertex Pharma
Priority to JP2002526864A priority Critical patent/JP2004509120A/en
Priority to AU2001290795A priority patent/AU2001290795A1/en
Priority to CA002418720A priority patent/CA2418720A1/en
Priority to EP01970836A priority patent/EP1317454B1/en
Priority to AT01970836T priority patent/ATE510837T1/en
Publication of WO2002022611A2 publication Critical patent/WO2002022611A2/en
Publication of WO2002022611A3 publication Critical patent/WO2002022611A3/en

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Abstract

Described herein are compounds that are useful as caspase inhibitors having the formula (I):wherein Ring A is an optionally substituted piperidine, tetrahydorquinoline or tetrahydroisoquinoline ring; R1 is hydrogen, CN, CHN2, R, or CH2Y; R is an optionally substituted group selected from an aliphatic group, an aryl group, or an aralkyl group; Y is an electronegative leaving group; R?2 is CO2H, CH2CO2¿H, or esters, amides or isosteres thereof; and R3 is hydrogen, an optionally substituted aryl group, and optionally substituted aralkyl group, or an optionally substituted C¿1-6? aliphatic group, R?4¿ is an optionally substituted group selected from an aryl group or a heterocycle group, or R?3 and R4¿ taken toegether with the nitrogen to which they are attached optionally form a substituted or unsubstituted monocyclic, bicyclic or tricyclic ring.
PCT/US2001/028450 2000-09-13 2001-09-12 Caspase inhibitors and uses thereof WO2002022611A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2002526864A JP2004509120A (en) 2000-09-13 2001-09-12 Caspase inhibitors and their uses
AU2001290795A AU2001290795A1 (en) 2000-09-13 2001-09-12 Caspase inhibitors and uses thereof
CA002418720A CA2418720A1 (en) 2000-09-13 2001-09-12 Caspase inhibitors and uses thereof
EP01970836A EP1317454B1 (en) 2000-09-13 2001-09-12 Caspase inhibitors and uses thereof
AT01970836T ATE510837T1 (en) 2000-09-13 2001-09-12 CASPASE INHIBITORS AND THEIR USE

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23257300P 2000-09-13 2000-09-13
US60/232,573 2000-09-13

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