WO2002002806A3 - Method and nucleic acids for analysing the methylation of genes implicated in pharmacogenomics - Google Patents

Method and nucleic acids for analysing the methylation of genes implicated in pharmacogenomics Download PDF

Info

Publication number
WO2002002806A3
WO2002002806A3 PCT/EP2001/007470 EP0107470W WO0202806A3 WO 2002002806 A3 WO2002002806 A3 WO 2002002806A3 EP 0107470 W EP0107470 W EP 0107470W WO 0202806 A3 WO0202806 A3 WO 0202806A3
Authority
WO
WIPO (PCT)
Prior art keywords
pharmacogenomics
analysing
methylation
nucleic acids
genes implicated
Prior art date
Application number
PCT/EP2001/007470
Other languages
French (fr)
Other versions
WO2002002806A2 (en
Inventor
Alexander Olek
Christian Piepenbrock
Kurt Berlin
Original Assignee
Epigenomics Ag
Alexander Olek
Christian Piepenbrock
Kurt Berlin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10032529A external-priority patent/DE10032529A1/en
Application filed by Epigenomics Ag, Alexander Olek, Christian Piepenbrock, Kurt Berlin filed Critical Epigenomics Ag
Priority to US10/257,166 priority Critical patent/US20040023230A1/en
Priority to EP01953995A priority patent/EP1294947A2/en
Priority to JP2002507050A priority patent/JP2004501666A/en
Priority to AU2001276371A priority patent/AU2001276371A1/en
Publication of WO2002002806A2 publication Critical patent/WO2002002806A2/en
Publication of WO2002002806A3 publication Critical patent/WO2002002806A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00—Reactions characterised by treatment of reaction samples
    • C12Q2523/10—Characterised by chemical treatment
    • C12Q2523/125—Bisulfite(s)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Saccharide Compounds (AREA)

Abstract

The present invention relates to the chemically modified genomic sequences of genes associated with pharmacogenomics, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genes associated with pharmacogenomics which are directed against the sequence, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes associated with pharmacogenomics.
PCT/EP2001/007470 2000-06-30 2001-06-29 Method and nucleic acids for analysing the methylation of genes implicated in pharmacogenomics WO2002002806A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US10/257,166 US20040023230A1 (en) 2000-06-30 2001-06-29 Method and nucleic acids for pharmacogenomic methylation analysis
EP01953995A EP1294947A2 (en) 2000-06-30 2001-06-29 Method and nucleic acids for pharmacogenomic methylation analysis
JP2002507050A JP2004501666A (en) 2000-06-30 2001-06-29 Methods and nucleic acids for methylation status analysis of pharmacogenomics
AU2001276371A AU2001276371A1 (en) 2000-06-30 2001-06-29 Method and nucleic acids for analysing the methylation of genes implicated pharmacogenomics

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10032529.7 2000-06-30
DE10032529A DE10032529A1 (en) 2000-06-30 2000-06-30 Diagnosis of major genetic parameters within the Major Histocompatibility Complex (MHC)
DE10043826 2000-09-01
DE10043826.1 2000-09-01

Publications (2)

Publication Number Publication Date
WO2002002806A2 WO2002002806A2 (en) 2002-01-10
WO2002002806A3 true WO2002002806A3 (en) 2002-05-16

Family

ID=26006285

Family Applications (8)

Application Number Title Priority Date Filing Date
PCT/EP2001/007470 WO2002002806A2 (en) 2000-06-30 2001-06-29 Method and nucleic acids for analysing the methylation of genes implicated in pharmacogenomics
PCT/EP2001/007472 WO2002000926A2 (en) 2000-06-30 2001-06-29 Diagnosis of diseases associated with signal transduction
PCT/EP2001/007471 WO2002002807A2 (en) 2000-06-30 2001-06-29 Diagnosis of diseases associated with cell signalling
PCT/EP2001/007540 WO2002002809A2 (en) 2000-06-30 2001-07-02 Diagnosis of behavioural disorders, neurological disorders and cancer
PCT/EP2001/007539 WO2002000705A2 (en) 2000-06-30 2001-07-02 Method and nucleic acids for the differentiation of astrocytoma, oligoastrocytoma and oligodendroglioma tumor cells
PCT/EP2001/007537 WO2002000928A2 (en) 2000-06-30 2001-07-02 Diagnosis of diseases associated with the immune system by determining cytosine methylation
PCT/EP2001/007536 WO2002000927A2 (en) 2000-06-30 2001-07-02 Diagnosis of diseases associated with development by means of assessing their methylation status
PCT/EP2001/007538 WO2002002808A2 (en) 2000-06-30 2001-07-02 Method and nucleic acids for the analysis of astrocytomas

Family Applications After (7)

Application Number Title Priority Date Filing Date
PCT/EP2001/007472 WO2002000926A2 (en) 2000-06-30 2001-06-29 Diagnosis of diseases associated with signal transduction
PCT/EP2001/007471 WO2002002807A2 (en) 2000-06-30 2001-06-29 Diagnosis of diseases associated with cell signalling
PCT/EP2001/007540 WO2002002809A2 (en) 2000-06-30 2001-07-02 Diagnosis of behavioural disorders, neurological disorders and cancer
PCT/EP2001/007539 WO2002000705A2 (en) 2000-06-30 2001-07-02 Method and nucleic acids for the differentiation of astrocytoma, oligoastrocytoma and oligodendroglioma tumor cells
PCT/EP2001/007537 WO2002000928A2 (en) 2000-06-30 2001-07-02 Diagnosis of diseases associated with the immune system by determining cytosine methylation
PCT/EP2001/007536 WO2002000927A2 (en) 2000-06-30 2001-07-02 Diagnosis of diseases associated with development by means of assessing their methylation status
PCT/EP2001/007538 WO2002002808A2 (en) 2000-06-30 2001-07-02 Method and nucleic acids for the analysis of astrocytomas

Country Status (5)

Country Link
US (5) US20040023230A1 (en)
EP (9) EP1297185A2 (en)
JP (1) JP2004501666A (en)
AU (8) AU2001276371A1 (en)
WO (8) WO2002002806A2 (en)

Families Citing this family (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20000070174A (en) 1997-01-14 2000-11-25 벤슨 로버트 에이치. Tumor necrosis factor receptors 6α and 6β
US7285267B2 (en) 1997-01-14 2007-10-23 Human Genome Sciences, Inc. Tumor necrosis factor receptors 6α & 6β
US6818404B2 (en) 1997-10-23 2004-11-16 Exact Sciences Corporation Methods for detecting hypermethylated nucleic acid in heterogeneous biological samples
US8076063B2 (en) * 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US7611869B2 (en) * 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
AU2001276330B2 (en) 2000-04-06 2006-08-31 Epigenomics Ag Diagnosis of diseases associated with apoptosis
AU2001281311A1 (en) * 2000-07-10 2002-01-21 Epigenx Pharmaceutical, Inc. Detecting methylated cytosine in polynucleotides
JP2002034575A (en) * 2000-07-28 2002-02-05 Shiseido Co Ltd Human type ii 5 alpha-reductase promoter gene and its use
DE10054974A1 (en) * 2000-11-06 2002-06-06 Epigenomics Ag Diagnosis of diseases associated with Cdk4
DE10061338A1 (en) * 2000-12-06 2002-06-20 Epigenomics Ag Diagnosis of diseases associated with angiogenesis
US6756200B2 (en) * 2001-01-26 2004-06-29 The Johns Hopkins University School Of Medicine Aberrantly methylated genes as markers of breast malignancy
EP1410304A2 (en) * 2001-03-26 2004-04-21 Epigenomics AG Method for epigenetic feature selection
WO2002083921A2 (en) 2001-04-10 2002-10-24 Agensys, Inc. Nuleic acids and corresponding proteins useful in the detection and treatment of various cancers
US7235358B2 (en) 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
DE10128508A1 (en) 2001-06-14 2003-02-06 Epigenomics Ag Methods and nucleic acids for the differentiation of prostate tumors
AU2002342004A1 (en) 2001-10-05 2003-04-22 Case Western Reserve University Methods and compositions for detecting colon cancers
US20110151438A9 (en) 2001-11-19 2011-06-23 Affymetrix, Inc. Methods of Analysis of Methylation
US20030211522A1 (en) * 2002-01-18 2003-11-13 Landes Gregory M. Methods for fetal DNA detection and allele quantitation
EP1470255A2 (en) * 2002-01-30 2004-10-27 Epigenomics AG Identification of cell differentiation states based on methylation patterns
EP1340818A1 (en) * 2002-02-27 2003-09-03 Epigenomics AG Method and nucleic acids for the analysis of a colon cell proliferative disorder
CN1650033A (en) * 2002-03-07 2005-08-03 约翰霍普金斯大学医学院 Genomic screen for epigenetically silenced genes associated with cancer
AU2003247880B2 (en) * 2002-07-03 2010-09-02 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7605138B2 (en) * 2002-07-03 2009-10-20 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US20040053880A1 (en) 2002-07-03 2004-03-18 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7807803B2 (en) 2002-07-03 2010-10-05 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US20040029128A1 (en) * 2002-08-08 2004-02-12 Epigenomics, Inc. Methods and nucleic acids for the analysis of CpG dinucleotide methylation status associated with the calcitonin gene
ES2447566T3 (en) 2002-10-01 2014-03-12 Epigenomics Ag Use of PITX2 nucleic acids to improve the treatment of breast cell proliferative disorders
DE60331852D1 (en) * 2002-12-02 2010-05-06 Illumina Cambridge Ltd DETERMINATION OF THE METHYLATION OF NUCLEIC ACID SEQUENCES
AU2003303963A1 (en) * 2002-12-20 2004-10-25 Bioseek, Inc. Drug target
ITRM20030149A1 (en) 2003-04-02 2004-10-03 Giuliani Spa ANTISENSE OLIGONUCLEOTIDES (ODN) FOR SMAD7 AND THEIR USE IN THE MEDICAL FIELD
US20050009059A1 (en) * 2003-05-07 2005-01-13 Affymetrix, Inc. Analysis of methylation status using oligonucleotide arrays
US7430335B2 (en) 2003-08-13 2008-09-30 Apple Inc Pre-processing method and system for data reduction of video sequences and bit rate reduction of compressed video sequences using spatial filtering
US7403568B2 (en) 2003-08-13 2008-07-22 Apple Inc. Pre-processing method and system for data reduction of video sequences and bit rate reduction of compressed video sequences using temporal filtering
US8062849B2 (en) 2003-10-28 2011-11-22 The Johns Hopkins University Quantitative multiplex methylation-specific PCR
ES2801379T3 (en) 2003-12-01 2021-01-11 Epigenomics Ag Methods and nucleic acids for the analysis of gene expression associated with the development of proliferative disorders of prostate cells
EP1561821B1 (en) 2003-12-11 2011-02-16 Epigenomics AG Prognostic markers for prediction of treatment response and/or survival of breast cell proliferative disorder patients
EP2290074B1 (en) 2004-05-28 2014-12-17 Asuragen, Inc. Methods and compositions involving microRNA
EP2302073A1 (en) * 2004-07-18 2011-03-30 Epigenomics AG Epigenetic methods and nucleic acids for the detection of breast cell proliferative disorders
US20080171318A1 (en) * 2004-09-30 2008-07-17 Epigenomics Ag Epigenetic Methods and Nucleic Acids for the Detection of Lung Cell Proliferative Disorders
EP2287303B1 (en) 2004-11-12 2014-07-02 Asuragen, Inc. Methods and compositions involving miRNA and miRNA inhibitor molecules
US20060134650A1 (en) * 2004-12-21 2006-06-22 Illumina, Inc. Methylation-sensitive restriction enzyme endonuclease method of whole genome methylation analysis
EP1693468A1 (en) 2005-02-16 2006-08-23 Epigenomics AG Method for determining the methylation pattern of a polynucleic acid
EP1863924A2 (en) 2005-03-11 2007-12-12 Epiontis GmbH Specific dnas for epigenetic characterisation of cells and tissues
EP1748080A3 (en) * 2005-03-11 2007-04-11 Epiontis GmbH Specific DNAs for epigenetic characterisation of cells and tissues
PL1871912T3 (en) 2005-04-15 2012-07-31 Epigenomics Ag Method for determining DNA methylation in blood or urine samples
WO2006111586A2 (en) * 2005-04-20 2006-10-26 Proyecto De Biomedicina Cima, S.L. Method for the in vitro determination of the degree of methylation of the line-1 promoter
US20060292585A1 (en) * 2005-06-24 2006-12-28 Affymetrix, Inc. Analysis of methylation using nucleic acid arrays
WO2007003397A2 (en) * 2005-07-01 2007-01-11 Epigenomics Ag Method and nucleic acids for the improved treatment of cancers
WO2007032748A1 (en) * 2005-09-15 2007-03-22 Agency For Science, Technology & Research Method for detecting dna methylation
CA2629008A1 (en) 2005-11-08 2007-09-13 Euclid Diagnostics Llc Materials and methods for assaying for methylation of cpg islands associated with genes in the evaluation of cancer
US20070161006A1 (en) * 2006-01-10 2007-07-12 Vita Genomics, Inc. Single nucleotide polymorphisms in protein-tyrosine phosphatase receptor-type delta for the diagnosis of susceptibility to infection and asthma
WO2007095032A2 (en) * 2006-02-09 2007-08-23 Novartis Ag Mutations and polymorphisms of ptk2b
US20070238115A1 (en) * 2006-02-27 2007-10-11 Dwinell Michael B Method of Diagnosing and Treating Colon Cancer
US7901882B2 (en) 2006-03-31 2011-03-08 Affymetrix, Inc. Analysis of methylation using nucleic acid arrays
US8084734B2 (en) * 2006-05-26 2011-12-27 The George Washington University Laser desorption ionization and peptide sequencing on laser induced silicon microcolumn arrays
AU2007254983A1 (en) * 2006-05-31 2007-12-13 Orion Genomics Llc Gene methylation in cancer diagnosis
EP2634265B1 (en) * 2006-07-21 2016-09-14 Epigenomics AG Methods related to the gene GLI3 for detection of colorectal cancer
AU2007299828C1 (en) * 2006-09-19 2014-07-17 Interpace Diagnostics, Llc MicroRNAs differentially expressed in pancreatic diseases and uses thereof
CN101622350A (en) * 2006-12-08 2010-01-06 奥斯瑞根公司 miR-126 regulated genes and pathways as targets for therapeutic intervention
GB0625321D0 (en) * 2006-12-19 2007-01-24 Univ Surrey Cancer biomarker
CA2667302C (en) 2007-01-18 2013-06-25 Molecor Tecnologia S.L. System for the manufacturing of integrated sockets in biaxially oriented plastic pipes
US20090170087A1 (en) 2007-02-02 2009-07-02 Orion Genomics Llc Gene Methylation in Cervical Cancer Diagnosis
WO2008096146A1 (en) * 2007-02-07 2008-08-14 Solexa Limited Preparation of templates for methylation analysis
US20090131354A1 (en) * 2007-05-22 2009-05-21 Bader Andreas G miR-126 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
EP2198050A1 (en) 2007-09-14 2010-06-23 Asuragen, INC. Micrornas differentially expressed in cervical cancer and uses thereof
WO2009052386A1 (en) * 2007-10-18 2009-04-23 Asuragen, Inc. Micrornas differentially expressed in lung diseases and uses thereof
US8071562B2 (en) 2007-12-01 2011-12-06 Mirna Therapeutics, Inc. MiR-124 regulated genes and pathways as targets for therapeutic intervention
WO2009108917A2 (en) * 2008-02-29 2009-09-03 Oncomethylome Sciences, S.A. Markers for improved detection of breast cancer
EP2268832A2 (en) * 2008-03-06 2011-01-05 Asuragen, INC. Microrna markers for recurrence of colorectal cancer
US8258111B2 (en) 2008-05-08 2012-09-04 The Johns Hopkins University Compositions and methods related to miRNA modulation of neovascularization or angiogenesis
EP2340314B8 (en) 2008-10-22 2015-02-18 Illumina, Inc. Preservation of information related to genomic dna methylation
US8110796B2 (en) 2009-01-17 2012-02-07 The George Washington University Nanophotonic production, modulation and switching of ions by silicon microcolumn arrays
WO2010091296A2 (en) * 2009-02-06 2010-08-12 The Regents Of The University Of California Emx2 in cancer diagnosis and prognosis
US9490113B2 (en) * 2009-04-07 2016-11-08 The George Washington University Tailored nanopost arrays (NAPA) for laser desorption ionization in mass spectrometry
KR20120051638A (en) * 2009-06-09 2012-05-22 배너 선 헬스 리서치 인스티튜트 Method and system to detect, diagnose, and monitor the progression of alzheimer's disease
EP2494067A1 (en) * 2009-10-28 2012-09-05 Signature Diagnostics AG Method for the prognosis of ovarian carcinoma
US9394570B2 (en) * 2010-04-21 2016-07-19 The Chinese University Of Hong Kong Marker for colon cancer and method for detecting colon cancer
DK2614952T3 (en) 2010-09-06 2016-06-27 Molecor Tecnologia Sl DEVICES AND METHOD FOR PRODUCING mouths of biaxially oriented plastic pipe having INTEGRATED SEAL PACKAGING
US9222088B2 (en) * 2010-10-22 2015-12-29 Curna, Inc. Treatment of alpha-L-iduronidase (IDUA) related diseases by inhibition of natural antisense transcript to IDUA
WO2012162139A1 (en) 2011-05-20 2012-11-29 The Regents Of The University Of California Method to estimate age of individual based on epigenetic markers in biological sample
JP6085603B2 (en) * 2011-08-25 2017-02-22 クリニカル ゲノミクス プロプライエタリー リミテッド DNA methylation in colorectal and breast cancer diagnostics
US9644241B2 (en) 2011-09-13 2017-05-09 Interpace Diagnostics, Llc Methods and compositions involving miR-135B for distinguishing pancreatic cancer from benign pancreatic disease
WO2013131083A1 (en) * 2012-03-02 2013-09-06 Winthrop-University Hospital METHOD FOR USING PROBE BASED PCR DETECTION TO MEASURE THE LEVELS OF CIRCULATING DEMETHYLATED β CELL DERIVED DNA AS A MEASURE OF β CELL LOSS IN DIABETES
WO2014071281A1 (en) 2012-11-02 2014-05-08 The Johns Hopkins University Dna methylation biomarkers of post-partum depression risk
ES2712798T3 (en) 2013-03-14 2019-05-14 Exact Sciences Dev Co Llc Detection of neoplasms
ES2527724B1 (en) * 2013-05-29 2015-11-10 Fundación Para La Investigación Biomédica Del Hospital Universitario La Paz METHOD FOR PREACHING THE RESPONSE TO THE TREATMENT WITH RADIOTHERAPY COMBINED WITH CISPLATINO-BASED CHEMOTHERAPY
WO2015153283A1 (en) 2014-03-31 2015-10-08 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasm
US9840742B2 (en) * 2014-06-16 2017-12-12 JBS Science Inc. Detection of hepatitis B virus (HBV) DNA and methylated HBV DNA in urine of patients with HBV-associated hepatocellular carcinoma
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
US10030272B2 (en) 2015-02-27 2018-07-24 Mayo Foundation For Medical Education And Research Detecting gastrointestinal neoplasms
US20180230539A1 (en) * 2015-07-21 2018-08-16 Indiana University Research And Technology Corporation Cell-free methylated and unmethylated dna in diseases resulting from abnormalities in blood glucose levels
CN108138235B (en) 2015-08-31 2022-04-15 梅约医药教育及研究基金会 Detection of gastric tumors
CA3020628A1 (en) 2016-04-14 2017-10-19 Mayo Foundation For Medical Education And Research Detecting pancreatic high-grade dysplasia
US10370726B2 (en) 2016-04-14 2019-08-06 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasia
CN105734152B (en) * 2016-04-20 2019-02-26 苏州吉诺瑞生物科技有限公司 Detect the primer pair and its application of the expression of people SRPK2 gene
EP4293128A3 (en) * 2016-09-02 2024-03-20 Mayo Foundation for Medical Education and Research Detecting hepatocellular carcinoma
US20190284636A1 (en) * 2016-10-26 2019-09-19 Brown University A method to measure myeloid suppressor cells for diagnosis and prognosis of cancer
CN110431241B (en) 2017-02-28 2024-04-19 梅约医学教育与研究基金会 Detection of prostate cancer
AU2018374176A1 (en) 2017-11-30 2020-06-11 Exact Sciences Corporation Detecting breast cancer
KR102512282B1 (en) * 2017-12-01 2023-03-23 바이오체인 (베이징) 사이언스 앤드 테크놀로지, 인크. Composition for detecting esophageal cancer and use thereof
CN108977457B (en) * 2018-08-31 2021-04-02 长江大学 Preparation method of finless eel antibacterial peptide
EP3911761A4 (en) 2019-01-18 2022-10-19 The Regents of the University of California Dna methylation measurement for mammals based on conserved loci
DE102020111423B4 (en) 2020-04-27 2022-03-03 Precision For Medicine Gmbh MYH11/NDE1 region as an epigenetic marker for the identification of endothelial progenitor cells (EPCs)
MX2023000105A (en) * 2020-06-23 2023-04-25 Univ Colorado Regents Methods for diagnosing respiratory pathogens and predicting covid-19 related outcomes.
EP4196611A1 (en) 2020-08-15 2023-06-21 Regeneron Pharmaceuticals, Inc. Treatment of obesity in subjects having variant nucleic acid molecules encoding calcitonin receptor (calcr)
WO2023175019A1 (en) 2022-03-15 2023-09-21 Genknowme S.A. Method determining the difference between the biological age and the chronological age of a subject

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5744305A (en) * 1989-06-07 1998-04-28 Affymetrix, Inc. Arrays of materials attached to a substrate
WO1999028498A2 (en) * 1997-11-27 1999-06-10 Epigenomics Gmbh Method for producing complex dna methylation fingerprints
WO1999029898A2 (en) * 1997-12-05 1999-06-17 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Method for identifying nucleic acids by means of matrix-assisted laser desorption/ionisation mass spectrometry
DE19905082C1 (en) * 1999-01-29 2000-05-18 Epigenomics Gmbh Identification of methylation patterns of cytosine in genome DNA comprises chemical treatment to produce different base pairing behavior between cytosine and 5-methylcytosine

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4965188A (en) * 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5843654A (en) * 1992-12-07 1998-12-01 Third Wave Technologies, Inc. Rapid detection of mutations in the p53 gene
US5837832A (en) * 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
AU8126694A (en) * 1993-10-26 1995-05-22 Affymax Technologies N.V. Arrays of nucleic acid probes on biological chips
US5804407A (en) * 1993-11-04 1998-09-08 University Technologies International, Inc. Method of expressing genes in mammalian cells
US5756668A (en) * 1994-11-15 1998-05-26 The Johns Hopkins University School Of Medicine Hypermethylated in cancer polypeptide, HIC-1
US6017704A (en) * 1996-06-03 2000-01-25 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
AU7829398A (en) * 1997-06-09 1998-12-30 University Of Southern California A cancer diagnostic method based upon dna methylation differences
US6342350B1 (en) * 1997-09-05 2002-01-29 The General Hospital Corporation Alpha-2-macroglobulin diagnostic test
JP2004507214A (en) * 2000-03-15 2004-03-11 エピゲノミクス　アーゲー Diagnosis of tumor suppressor genes and diseases related to oncogenes
AU2001276330B2 (en) * 2000-04-06 2006-08-31 Epigenomics Ag Diagnosis of diseases associated with apoptosis
DE10128508A1 (en) * 2001-06-14 2003-02-06 Epigenomics Ag Methods and nucleic acids for the differentiation of prostate tumors
WO2003004696A2 (en) * 2001-07-02 2003-01-16 Epigenomics Ag A distributed system for epigenetic based prediction of complex phenotypes

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5744305A (en) * 1989-06-07 1998-04-28 Affymetrix, Inc. Arrays of materials attached to a substrate
WO1999028498A2 (en) * 1997-11-27 1999-06-10 Epigenomics Gmbh Method for producing complex dna methylation fingerprints
WO1999029898A2 (en) * 1997-12-05 1999-06-17 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Method for identifying nucleic acids by means of matrix-assisted laser desorption/ionisation mass spectrometry
DE19905082C1 (en) * 1999-01-29 2000-05-18 Epigenomics Gmbh Identification of methylation patterns of cytosine in genome DNA comprises chemical treatment to produce different base pairing behavior between cytosine and 5-methylcytosine

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] EBI; 21 July 1995 (1995-07-21), YOSHIDA A., ET AL.: "Human aldehyde dehydrogenase 1 (ALDH1) gene, promoter region and partial cds.", XP002181030, retrieved from HTTP://WWW.EBI.AC.UK/CGI-BIN/EMBLFETCH Database accession no. U28416 *
DATABASE EMBL [online] EBI; 9 July 1993 (1993-07-09), YOSHIDA A., ET AL.: "ALDH1=aldehyde dehydrogenase 1 {5' region} [human, Genomic, 971 nt]", XP002181031, retrieved from HTTP://WWW.EBI.AC.UK/CGI-BIN/EMBLFETCH Database accession no. S61235 *
DATABASE GENBANK [online] NCBI; 22 November 1994 (1994-11-22), KIMURA, S. ET AL.: "Human cytochrome P450 IID6 (CYP2D6) gene, complete cds.", XP002181029, retrieved from HTTP://WWW.NCBI.NLM.NIH.GOV Database accession no. M33388 *
KIMURA S., ET AL.: "The human debrisoquine 4-hydroxylase (CYP2d) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene.", AM. J. HUM. GENET., vol. 45, no. 6, December 1989 (1989-12-01), pages 889 - 904, XP001033901 *
YANAGAWA, Y., ET AL.: "The transcriptional regulation of human aldehyde dehydrogenase I gene.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 29, 21 July 1995 (1995-07-21), pages 17521 - 17527, XP002181225 *
YOSHIDA A., ET AL.: "Biological role of human cytosolic aldehyde dehydrogenase 1. hormonal response, retinal oxidation and implication in testicular feminization.", ADV. EXP. MED. BIOL., vol. 328, 1993, pages 37 - 44, XP002181226 *

Also Published As

Publication number Publication date
WO2002002806A2 (en) 2002-01-10
WO2002002807A3 (en) 2002-08-08
AU2001287576A1 (en) 2002-01-08
WO2002000926A3 (en) 2002-11-21
WO2002000926A2 (en) 2002-01-03
WO2002000927A3 (en) 2002-07-18
AU2001287575A1 (en) 2002-01-08
EP1297182A2 (en) 2003-04-02
JP2004501666A (en) 2004-01-22
US20040023230A1 (en) 2004-02-05
WO2002000926A8 (en) 2002-07-18
WO2002002807A8 (en) 2002-05-30
WO2002002809A3 (en) 2003-01-30
US20030143606A1 (en) 2003-07-31
EP1676927A3 (en) 2006-12-06
EP1297185A2 (en) 2003-04-02
US20080145839A1 (en) 2008-06-19
EP1356099A2 (en) 2003-10-29
EP1294947A2 (en) 2003-03-26
AU2001283915A1 (en) 2002-01-08
WO2002002808A3 (en) 2003-09-04
US20040115630A1 (en) 2004-06-17
WO2002000927A2 (en) 2002-01-03
EP1294951A2 (en) 2003-03-26
AU2001279707A1 (en) 2002-01-14
AU2001276371A1 (en) 2002-01-14
EP1294950A2 (en) 2003-03-26
EP1676927A2 (en) 2006-07-05
WO2002000928A2 (en) 2002-01-03
WO2002000705A2 (en) 2002-01-03
WO2002000705A3 (en) 2003-08-14
WO2002002809A2 (en) 2002-01-10
WO2002000928A3 (en) 2002-08-01
EP1355932A2 (en) 2003-10-29
US20080026396A1 (en) 2008-01-31
WO2002002808A2 (en) 2002-01-10
WO2002002807A2 (en) 2002-01-10
AU2001283916A1 (en) 2002-01-14
WO2002000927A8 (en) 2002-03-21
AU2001277521A1 (en) 2002-01-14
AU2001289617A1 (en) 2002-01-08
EP1294948A2 (en) 2003-03-26

Similar Documents

Publication Publication Date Title
WO2002002806A3 (en) Method and nucleic acids for analysing the methylation of genes implicated in pharmacogenomics
WO2001081622A8 (en) Diagnosis of diseases associated with dna repair
WO2001068911A3 (en) Diagnosis of diseases associated with the cell cycle
WO2002077272A3 (en) Methods and nucleic acids for the analysis of hematopoietic cell proliferative disorders
WO2001071042A8 (en) Detection kits, such as nucleic acid arrays, for detecting the expression of 10,000 or more drosophila genes and uses thereof
WO2004035803A3 (en) Method and nucleic acids for the treatment of breast cell proliferative disorders
WO2003052135A8 (en) Method and nucleic acids for the analysis of a lung cell proliferative disorder
WO2003014388A3 (en) Method and nucleic acids for the analysis of colon cancer
WO2004020662A3 (en) Method and nucleic acids for the analysis of breast cell proliferative disorders
WO2002103042A3 (en) Method and nucleic acids for the differentiation of prostate tumors
WO2002046454A3 (en) Diagnosis of diseases associated with angiogenesis by determining the methylation of genes associated with angiogenesis
WO2003044226A3 (en) Method and nucleic acids for the analysis of a lymphoid cell proliferative disorder
WO2002036814A3 (en) Diagnosis of diseases associated with cdk4 by determining the methylation state of the cdk4
WO2002012554A3 (en) Diagnosis of diseases which are associated with cd24
WO2002103041A3 (en) Method and nucleic acids for the differentiation of prostate and renal carcinomas
WO2002036604A3 (en) Diagnosis of diseases associated with the human c-mos gene
EP1688493A4 (en) Method of detecting genetic polymorphism

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 2001953995

Country of ref document: EP

ENP Entry into the national phase

Ref country code: JP

Ref document number: 2002 507050

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 2001276371

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 10257166

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 2001953995

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWW Wipo information: withdrawn in national office

Ref document number: 2001953995

Country of ref document: EP