WO2001028542A3 - Combination therapy including camptothecin - Google Patents

Combination therapy including camptothecin Download PDF

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Publication number
WO2001028542A3
WO2001028542A3 PCT/US2000/025105 US0025105W WO0128542A3 WO 2001028542 A3 WO2001028542 A3 WO 2001028542A3 US 0025105 W US0025105 W US 0025105W WO 0128542 A3 WO0128542 A3 WO 0128542A3
Authority
WO
WIPO (PCT)
Prior art keywords
camptothecin
combination therapy
therapy including
including camptothecin
effective amount
Prior art date
Application number
PCT/US2000/025105
Other languages
French (fr)
Other versions
WO2001028542A2 (en
Inventor
Joseph Rubinfeld
Original Assignee
Supergen Inc
Joseph Rubinfeld
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Supergen Inc, Joseph Rubinfeld filed Critical Supergen Inc
Priority to AU73772/00A priority Critical patent/AU7377200A/en
Priority to EP00961879A priority patent/EP1223934A2/en
Publication of WO2001028542A2 publication Critical patent/WO2001028542A2/en
Publication of WO2001028542A3 publication Critical patent/WO2001028542A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A method for treating diseases comprises delivering to a patient in need of treatment a therapeutically effective amount of 20(S)-camptothecin, an analog of 20(S)-camptothecin, or a derivative of 20(S)-camptothecin in combination with an effective amount of at least one of an alkylating agent, epidophyllotoxin, antimetabolite, antibiotic or vinca alkaloid.
PCT/US2000/025105 1999-10-15 2000-09-13 Combination therapy including camptothecin WO2001028542A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU73772/00A AU7377200A (en) 1999-10-15 2000-09-13 Combination therapy including camptothecin
EP00961879A EP1223934A2 (en) 1999-10-15 2000-09-13 Combination therapy including camptothecin

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/418,862 1999-10-15
US09/418,862 US6191119B1 (en) 1999-10-15 1999-10-15 Combination therapy including 9-nitro-20(S)-camptothecin

Publications (2)

Publication Number Publication Date
WO2001028542A2 WO2001028542A2 (en) 2001-04-26
WO2001028542A3 true WO2001028542A3 (en) 2002-01-10

Family

ID=23659848

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/025105 WO2001028542A2 (en) 1999-10-15 2000-09-13 Combination therapy including camptothecin

Country Status (4)

Country Link
US (4) US6191119B1 (en)
EP (2) EP1676576A1 (en)
AU (1) AU7377200A (en)
WO (1) WO2001028542A2 (en)

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US6441025B2 (en) * 1996-03-12 2002-08-27 Pg-Txl Company, L.P. Water soluble paclitaxel derivatives
US6485514B1 (en) * 1997-12-12 2002-11-26 Supergen, Inc. Local delivery of therapeutic agents
US6191119B1 (en) * 1999-10-15 2001-02-20 Supergen, Inc. Combination therapy including 9-nitro-20(S)-camptothecin
US6420378B1 (en) * 1999-10-15 2002-07-16 Supergen, Inc. Inhibition of abnormal cell proliferation with camptothecin and combinations including the same
CA2401340A1 (en) * 2000-02-28 2001-09-07 The University Of British Columbia Compositions and methods for the treatment of inflammatory disease using topoisomerase inhibitors
ES2273841T3 (en) 2000-02-28 2007-05-16 Pfizer Enterprises Sarl SYNERGIC COMBINATION FOR COLORRECTAL CANCER TREATMENT.
US9522217B2 (en) 2000-03-15 2016-12-20 Orbusneich Medical, Inc. Medical device with coating for capturing genetically-altered cells and methods for using same
US8088060B2 (en) 2000-03-15 2012-01-03 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
EP1716852A1 (en) * 2000-03-17 2006-11-02 Pfizer Enterprises SARL A composition comprising campothecin or a campothecin derivative and an alkylating agent for the treatment of cancer
US6548488B2 (en) 2000-03-17 2003-04-15 Aventis Pharma S.A. Composition comprising camptothecin or a camptothecin derivative and an alkylating agent for the treatment of cancer
US6545010B2 (en) * 2000-03-17 2003-04-08 Aventis Pharma S.A. Composition comprising camptothecin or a camptothecin derivative and a platin derivative for the treatment of cancer
US6629995B1 (en) * 2000-03-31 2003-10-07 Super Gen, Inc. Camptothecin conjugates
ATE309786T1 (en) * 2000-06-30 2005-12-15 Inex Pharmaceuticals Corp LIPOSOMAL ANTINEOPLASTIC DRUGS AND USES THEREOF
US6977247B2 (en) * 2002-02-21 2005-12-20 Supergen, Inc. Sequential therapy comprising a 20(S)-camptothecin and a pyrimidine base analog
EP1796644B1 (en) * 2004-09-07 2011-04-13 Biocompatibles UK Limited Drug delivery from embolic agents
JP4990786B2 (en) * 2004-11-05 2012-08-01 イネックス ファーマシューティカルズ コーポレイション Compositions and methods for stabilizing drug liposome formulations
CN100438913C (en) * 2004-11-22 2008-12-03 山东蓝金生物工程有限公司 Anti-cancer medicine composition
US20070123539A1 (en) * 2005-10-20 2007-05-31 University Of South Florida Treatment of Restenosis and Stenosis with Dasatinib
MX2015005992A (en) 2012-11-20 2016-03-07 Spectrum Pharmaceuticals Inc Improved method for the preparation of liposome encapsulated vincristine for therapeutic use.
TWI678213B (en) 2015-07-22 2019-12-01 美商史倍壯製藥公司 A ready-to-use formulation for vincristine sulfate liposome injection

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0517353A (en) * 1991-07-10 1993-01-26 Kanebo Ltd Carcinostatic action-enhancing agent

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US4740207A (en) 1986-09-10 1988-04-26 Kreamer Jeffry W Intralumenal graft
US5007926A (en) 1989-02-24 1991-04-16 The Trustees Of The University Of Pennsylvania Expandable transluminally implantable tubular prosthesis
US5147302A (en) 1989-04-21 1992-09-15 Scimed Life Systems, Inc. Method of shaping a balloon of a balloon catheter
US5053007A (en) 1989-12-14 1991-10-01 Scimed Life Systems, Inc. Compression balloon protector for a balloon dilatation catheter and method of use thereof
US5183085A (en) 1991-09-27 1993-02-02 Hans Timmermans Method and apparatus for compressing a stent prior to insertion
US5352236A (en) 1992-09-29 1994-10-04 Medtronic, Inc. Balloon protector
US5437083A (en) 1993-05-24 1995-08-01 Advanced Cardiovascular Systems, Inc. Stent-loading mechanism
US5604233A (en) * 1994-04-28 1997-02-18 Bionumerik Pharmaceuticals, Inc. Lactone stable formulation of 7-ethyl camptothecin and methods for uses thereof
US5786344A (en) * 1994-07-05 1998-07-28 Arch Development Corporation Camptothecin drug combinations and methods with reduced side effects
US5746764A (en) 1995-12-04 1998-05-05 Atrion Medical Products, Inc. Stent compression instrument
US5626604A (en) 1995-12-05 1997-05-06 Cordis Corporation Hand held stent crimping device
US5693066A (en) 1995-12-21 1997-12-02 Medtronic, Inc. Stent mounting and transfer device and method
US5731316A (en) * 1996-01-30 1998-03-24 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
EP0795334B1 (en) * 1996-03-12 2006-02-01 Sanofi-Aventis Deutschland GmbH Prodrugs for the treatment tumors and inflammatory diseases
US5868707A (en) 1996-08-15 1999-02-09 Advanced Cardiovascular Systems, Inc. Protective sheath for catheter balloons
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US5836952A (en) 1996-08-21 1998-11-17 Cordis Corporation Hand-held stent crimper
US5725519A (en) 1996-09-30 1998-03-10 Medtronic Instent Israel Ltd. Stent loading device for a balloon catheter
US5893867A (en) 1996-11-06 1999-04-13 Percusurge, Inc. Stent positioning apparatus and method
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US6420378B1 (en) * 1999-10-15 2002-07-16 Supergen, Inc. Inhibition of abnormal cell proliferation with camptothecin and combinations including the same
US6977247B2 (en) * 2002-02-21 2005-12-20 Supergen, Inc. Sequential therapy comprising a 20(S)-camptothecin and a pyrimidine base analog

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0517353A (en) * 1991-07-10 1993-01-26 Kanebo Ltd Carcinostatic action-enhancing agent

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
BERNACKI: "in vitro antitumour activity...", AAN. N. Y. ACAD.SCI., vol. 922, 2000, pages 293 - 297, XP000998793 *
CIESIELSKI M.J. ET AL: "Synergistic cytotoxicity, apoptosis and protein-linked DNA breakage by etoposide and camptothecin in human U87 glioma cells: Dependence on tyrosine phosphorylation.", JOURNAL OF NEURO-ONCOLOGY, (1999) 41/3 (223-234)., XP000997759 *
DAINIAK N ET AL: "DNA TOPOISOMERASE INHIBITORS BLOCK ERYTHROPOIESIS AND DELAY HEMOGLOBINIZATION IN-VITRO", JOURNAL OF CELLULAR PHYSIOLOGY, vol. 138, no. 1, 1989, pages 87 - 96, XP000997671, ISSN: 0021-9541 *
DATABASE WPI Section Ch Week 199309, Derwent World Patents Index; Class B02, AN 1993-071029, XP002165592 *
DREWINKO B ET AL: "COMBINATION CHEMO THERAPY IN-VITRO WITH ADRIAMYCIN OBSERVATIONS OF ADDITIVE ANTAGONISTIC AND SYNERGISTIC EFFECTS WHEN USED IN 2 DRUG COMBINATIONS ON CULTURED HUMAN LYMPHOMA CELLS", CANCER BIOCHEMISTRY BIOPHYSICS, vol. 1, no. 4, 1976, pages 187 - 195, XP000997672 *
GIOVANELLA: "enhanced antitumour effectiveness...", PROCEEDINGS OF THE AM. ASS. FOR CANCER RESEARCH ANNUAL MEETING, vol. 36, no. 0, 1995, pages 391, XP000992942 *
GUICHARD SYLVIE ET AL: "Cellular interactions of 5-fluorouracil and the camptothecin analogue CPT-11 (irinotecan) in a human colorectal carcinoma cell line.", BIOCHEMICAL PHARMACOLOGY, vol. 55, no. 5, 1 March 1998 (1998-03-01), pages 667 - 676, XP000997661, ISSN: 0006-2952 *
KARABERIS E ET AL: "Enhanced cytogenetic and antitumor effects by 9-nitrocamptothecin and antineoplastics.", TERATOGENESIS CARCINOGENESIS AND MUTAGENESIS, vol. 20, no. 3, 2000, pages 141 - 146, XP000997739, ISSN: 0270-3211 *
KAUFMANN S H: "ANTAGONISM BETWEEN CAMPTOTHECIN AND TOPOISOMERASE II-DIRECTED CHEMOTHERAPEUTIC AGENTS IN A HUMAN LEUKEMIA CELL LINE", CANCER RESEARCH, vol. 51, no. 4, 1991, pages 1129 - 1136, XP000997673, ISSN: 0008-5472 *
See also references of EP1223934A2 *
TAKIMOTO: "cancer chemotherapy and biotherapy", 1996, CHABNER, PHILADELPHIA, XP000998056 *

Also Published As

Publication number Publication date
US20020086818A1 (en) 2002-07-04
WO2001028542A2 (en) 2001-04-26
US6664233B1 (en) 2003-12-16
US6191119B1 (en) 2001-02-20
EP1676576A1 (en) 2006-07-05
AU7377200A (en) 2001-04-30
US20050130882A1 (en) 2005-06-16
EP1223934A2 (en) 2002-07-24

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