WO2001008661A2 - Opioid sustained-released formulation - Google Patents
Opioid sustained-released formulation Download PDFInfo
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- WO2001008661A2 WO2001008661A2 PCT/US2000/020413 US0020413W WO0108661A2 WO 2001008661 A2 WO2001008661 A2 WO 2001008661A2 US 0020413 W US0020413 W US 0020413W WO 0108661 A2 WO0108661 A2 WO 0108661A2
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- dosage form
- exchange resin
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- hydroxyalkylcellulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
- A61K47/585—Ion exchange resins, e.g. polystyrene sulfonic acid resin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Definitions
- the present invention relates to an improved pharmaceutical drug delivery composition. More particularly, the present invention is directed to a controlled release formulation, capable of providing sustained, prolonged, repeat and/or delayed release, and methods for preparing the same. Such formulations have improved delivery characteristics.
- sustained-release pharmaceutical preparations Many attempts have been made to design sustained-release pharmaceutical preparations to provide a more constant level of the drug in the blood over a set period of time.
- Many sustained-release preparations were originally contemplated as "convenience dosage forms," that is, dosage forms designed to improve QOL (that is, the "quality of life") of a patient by eliminating the necessity of dosing a patient several times during the day and by proffering the advantage of decreased missed doses which might result from the forgetfulness of a patient.
- a number of such preparations have subsequently been shown to provide clear therapeutic benefits which cannot be obtained by multiple dosing of their active drug component (especially those drugs which display high water solubility).
- sustained- release dosage forms are: (1) the allowance of more constant blood levels over time (thus avoiding large spike and trough levels not infrequently seen with rapidly dissolving dosage forms) leading to a more consistent therapeutic effect; (2) delay of the release of drug such that significant absorption of the drug may occur at more desirable sites (e.g., causing the bulk of the absorption to occur in a more desirable pH milieu and thus reducing decomposition of the drug); (3) reduction in concentration dependent gastrointestinal irritation (owing to reduction in the concentration of drug in contact with a particular surface of the gastrointestinal tract); and (4) improvement of drug safety with respect to acute toxicity owing to lower concentrations of drug being released at a particular time as compared to readily available dosage forms of similar dose.
- the matrices may be comprised of either erodable polymers (i.e., polymers that break down in the body) or non-erodable polymers (polymers that are substantially unchanged upon passage through the gastrointestinal tract).
- sustained release is effectuated by mixing the active drug product with one or more hydrophilic hydrocolloids such that when the hydrocolloids are contacted with gastric fluid at body temperature, a sustained gelatinous mix is formed on the surface of the dosage form.
- the gelatinous layer reduces the dissolution rate and eventuates in slow release of the drug from the surface of the dosage form.
- U.S. Patent Nos. 3,965,256 and 4,235,870 teach slow release pharmaceutical compositions employing hydroxyalkyl cellulose and a higher aliphatic alcohol
- U.S. Patent No. 4,140,755 to Sheth et al. discloses sustained release tablets utilizing hydroxypropylmethylcellulose having a viscosity of 4000 cps.
- hydroxypropylmethylcellulose (a series of compounds designated as Methocel E, F, J and K, each of which has a different chemical composition with a methoxyl content within the range of 16.5 to 30 weight percent, and a hydroxypropyl content within the range of 4 to 32 weight percent) matrix formulations is that drug release rates are generally independent of processing variables such as compaction pressure, drug particle size and the incorporation of lubricant (See, Feely et al., Int. J Pharmaceutics 41 (1988) 83 - 90). Admixture of hydroxypropylmethylcellulose with anionic surfactants is reported to improve prolongation of drug release (See, Alii et al., J.
- microencapsulate the drug in a polymeric composition thus providing a slower dissolution rate.
- Microcapsules are designed such that the gastric fluids slowly diffuse through the capsule walls, dissolving the active drug. The dissolved drug slowly diffuses or leaches out through the microcapsule wall into the body.
- U.S. Patent Nos. 3,155,590, 3,341,416, 3,488,418 and 3,531,418 are representative of early work involving microencapsulation techniques. While microencapsulation is used extensively in sustained-release formulations, microencapsulation of drugs frequently fails to provide a desired sustained-release profile in that the dissolution rate often decreases rapidly over time.
- sustained release formulations of medicaments by applying rupturable, relatively water-insoluble, water permeable films over an insoluble swelling type release matrix (such as a blend of polyvinyl pyrrolidone and carboxyvinyl hydrophilic polymer) which contains the medicament (See, e.g., U.S. Patent No. 4,252,786 to Weiss).
- an insoluble swelling type release matrix such as a blend of polyvinyl pyrrolidone and carboxyvinyl hydrophilic polymer
- Sustained release formulations containing actives in a coated core material are also known (See, e.g., U.S. Patent Nos. 4,248,857 and 4,309,405)
- Multilayering is also used to prepare solid dosage forms with sustained release profiles. Such technique involves incorporating into the dosage form two or more separate layers of granulation which are designed to release drug at different rates. By compounding each layer differently, the rate of dissolution of the layer may be controlled in a desired manner.
- Controlled drug release may also be effectuated by taking advantage of charge-charge interactions, such as reacting basic drugs with polymers having acidic moieties (See, e.g. U.S. Patent No. 3,608,063).
- charge-charge interactions such as reacting basic drugs with polymers having acidic moieties
- extended action has been obtained by loading drugs onto ion-exchange resins (See, Remington 's Pharmaceutical Sciences, 15th Ed. 1975). Such extended action is presumed to result from the slow rate of the displacement reaction when drug-resin complex contacts gastrointestinal fluids and ionic constituents are displaced from the resin, essentially by other ions. Sorption of the drug to the resin is believed to be primarily due to ionic electrostatic interactions (See, Jenquin et al., Int. J.
- amine containing drugs such as codeine (See, e.g. Amsel et al., Pharm. Tech. 8 (1984) 28) and propanolol (Burke et al., Drug DeveL Indust. Pharmacy 12 (1986) 713 - 732)
- codeine See, e.g. Amsel et al., Pharm. Tech. 8 (1984) 28
- propanolol (Burke et al., Drug DeveL Indust. Pharmacy 12 (1986) 713 - 732)
- strong cationic exchange resins yielding restricted elution of the drug from the resinates (See, Sanghvai et al, Indian Drugs 26 (1988) 27 - 32).
- Uncoated ion exchange resin-drug complexes which delay release of a drug in the gastrointestinal tract are described in U.S. Patent Nos.
- Opioid analgesics comprise the major class of drugs used in the management of moderate to severe pain. Until recently most opioid analgesics were available only in rapid dissolution forms. Because opioid drugs typically are metabolized and/or excreted relatively rapidly, dosing of rapid dissolution opioid preparations is typically frequent so that steady state blood levels may be maintained. Due to rapid dissolution and absorption which results in a relatively large peak to trough differential with regard to active drug concentrations, pain relief from rapid dissolution opioids is frequently found to be quite variable.
- sustained-release opioid analgesic formulations promise relief from pain with, in theory, minimal addiction liability owing to a substantially lower C max without compromise of analgesic efficacy.
- the approach taken by many manufacturers has been to develop sustained-release opioid formulations which provide zero order pharmacokinetics (thereby providing very slow opioid absorption and a generally flat serum concentration curve over time) to mimic a steady- state level.
- greater analgesic efficacy is achieved by formulations designed to provide more rapid initial opioid release within two to four hours, and which follow first order pharmacokinetics (See, e.g., U.S. Patent No.
- sustained-release opioid analgesic formulations employing, for example, granulation and coating of the opioid drug (e.g., with a water insoluble cellulose), to control the release of the drug (See, e.g., U.S. Patent Nos. 5,478,577, 5,580,578, 5,639,476, and 5,672,360), standard release matrices (See, e.g., U.S. Patent No. 5,226,331), drug loading onto a resin utilizing wet granulation (See, e.g., U.S. Patent Nos.
- sustained-release opioid analgesic formulations have improved therapeutic efficacy (i.e., dosing is less frequent and hence dosing compliance by patients is believed to be achieved over rapid dissolution-type dosage forms incorporating the same opioid analgesic) in practice, consistent amelioration of pain between administration of doses is often less than adequate. Further, manufacture of presently available sustained-release opioid analgesic formulations is complex, requiring specialized granulation and coating equipment, cumbersome techniques, and expensive excipients.
- the present invention provides an improved solid, oral dosage formulation for the in vivo sustained-release of opioid compounds, and salts thereof, and in particular for the sustained-release of opioid analgesics.
- the formulation comprises a simple mixture of a hydrophilic matrix-forming agent, ionic exchange resin, and one or more opioid compound(s).
- Such formulation may be prepared without the need for wet granulation of the mixture, drug loading of the resin, or the application of coating materials over the active component. However, wet granulation may be employed.
- Significantly improved formulations employ ionic exchange resins which are processed such that the particle size distribution of the resin is less than or equal to about 325 mesh, U.S. Standard mesh size, and the mean particle size of the resin particles is less than about 50 ⁇ m.
- an oxycodone formulation of the present invention comprises a therapeutically effective amount of oxycodone, or salt thereof, in a matrix wherein the dissolution rate in vitro of the dosage form, when measured by the USP Basket Method at 100 rpm in 900 mL aqueous buffer (pH 1.2 for the first hour and 7.5 for hours 2 through 12) at 37 ° C is between about 5 and 25% (by weight) oxycodone released over the first hour, between about 16 and 36% (by weight) oxycodone released after the second hour, between about 40 and 60% ⁇ (by weight) oxycodone released after six hours, and between about 60 and 80%> (by weight) oxycodone released after twelve hours.
- the release rate is independent of pH between about 1.2 and 7.5. Additionally, the peak plasma level of oxycodone obtained in vivo occurs between five and six hours after administration of the dosage form.
- formulations having from about 5 to about 100 mg oxycodone may be manufactured to have such release rates when the formulation comprises between about 30 and 65% matrix-forming polymer, more preferably between 50 - 60% matrix-forming polymer, and between about 1 and 20% ion exchange resin.
- Significantly improved formulations containing approximately 10 mg - 30 mg of oxycodone hydrochloride contain between about 50 to about 60% matrix-forming polymer and between about 5 and about 15% ion exchange resin.
- the present invention overcomes many of the prior art problems associated with sustained-release opioid formulations.
- the present inventor has discovered a unique sustained-release formulation and process for opioid compounds, and in particular opioid analgesics, which does not require polymeric coatings to be applied to the active, does not require wet granulation procedures in the preparation of the formulation (although wet granulation can be used if desired), and does not require drug loading onto exchange resins, and yet which provides an advantageous release profile of the active.
- a solid, oral, controlled release dosage form comprising a therapeutically effective amount of opioid compound, or a salt thereof, between about 30 and 65% of a matrix-forming polymer, more preferably between about 50 - 60% matrix-forming polymer, and between 5 and 15%) of a ionic exchange resin.
- the opioid compound included in the formulation is an opioid analgesic. It has been surprisingly found that a simple mixture of the matrix-forming agent with the opioid compound and ion-exchange resin, in the proportions disclosed, results in a formulation with improved opioid release kinetics without the need for, or recourse to, expensive coating procedures or wet granulation techniques.
- Coating and wet granulation may be used in conjunction with the present invention in order to obtain desired tablet configurations, but such procedures and techniques are optional.
- Such discovery is taught away from by presently available opioid analgesic sustained-release preparations, and goes against conventional thought with respect to highly water soluble drugs (such as the opioid analgesics) which points toward the desirability of drug loading onto the resin, of coating drug-resin complexes, and which suggests that uncoated complexes provide only a relatively short delay of drug release (See, e.g., U.S. Patent No. 4,996,047 to Kelleher et al).
- the present invention also provides a pharmaceutical preparation with a different pharmacokinetic profile. Peak plasma levels of, for example, oxycodone, five to six hours after administration presents a unique profile for an analgesic.
- opioid it is meant a substance, whether agonist, antagonist, or mixed agonist-antagonist, which reacts with one or more receptor sites bound by endogenous opioid peptides such as the enkephalins, endorphins and the dyno ⁇ hins.
- opioid analgesic it is meant a diverse group of drugs, of natural, synthetic, or semi-synthetic origin, that displays opium or mo ⁇ hine-like properties.
- Opioid analgesics include, without limitation, mo ⁇ hine, heroin, hydromo ⁇ hone, oxymo ⁇ hone, bupreno ⁇ hine, levo ⁇ hanol, buto ⁇ hanol, codeine, dihydrocodeine, hydrocodone, oxycodone, meperidine, methadone, nalbulphine, opium, pentazocine, propoxyphene, as well as less widely employed compounds such as alfentanil, allylprodine, alphaprodine, anileridine, benzylmo ⁇ hine, bezitramide, clonitazene, cyclazocine, desomo ⁇ hine, dextromoramide, dezocine, diampromide, dihydromo ⁇ hine, dimenoxadol, dimepheptanol, dimethylthiambutene, dioxaphetyl butyrate, dipipanone, eptazocine, etho
- Matrix-forming polymers useful in the present invention may comprise any polymer not readily degradable by the body.
- Typical matrix-forming polymers useful in the present invention include, without limitation, hydroxypropylmethyl cellulose (in particular having a molecular weight range of 50,000 to 1,250,000 daltons), ethylcellulose, methylcellulose, hydroxypropyl cellulose, hydroxyethyl cellulose, carboxymethyl cellulose calcium, sodium carboxymethylcellulose, hydroxypropylmethyl cellulose phthalate, cellulose acetate phthalate, carnauba wax and stearyl alcohol, carbomer, cetostearyl alcohol, cetyl alcohol, cetyl esters wax, guar gum, hydrogenated castor oil, magnesium aluminum silicate, maltodextrin, polyvinyl alcohol, polyvinyl chloride, polyethylene glycol, polyethylene glycol alginate, polymethacrylates, polyesters, polysaccharides, poloxamer, povidone, stearyl alcohol, gly
- a preferred matrix-forming polymer is alkylcellulose-based, more particularly hydroxyalkylcellulose-based.
- Alkylcellulose matrix-forming polymers were found unexpectedly to improve the release profile of opioids when used in conjunction with numerous types of ionic exchange resins. The most efficacious matrix-forming polymers were found to be hydrophilic in nature.
- ionic exchange resins useful in the present invention are styrene-divinylbenzene copolymers (e.g. IRP-69, IR-120, IRA- 400 and IRP- 67 — Rohm & Haas), copolymers of methacrylic acid and divinylbenzene (e.g. IRP-64 and IRP-88 - Rohm & Haas), phenolic polyamines (e.g., IRP-58 ⁇ Rohm & Haas), and styrene-divinylbenzene (e.g., colestyramine resin U.S.P.).
- styrene-divinylbenzene copolymers e.g. IRP-69, IR-120, IRA- 400 and IRP- 67 — Rohm & Haas
- copolymers of methacrylic acid and divinylbenzene e.g. IRP-64 and IRP-88
- the drug and resin should be oppositely charged such that the drug will bind to the resin when solubilized in the matrix formed by the matrix-former.
- the ionic exchange resin be cationic in nature, and most preferably be strongly acidic in nature.
- micronization of the ionic resin particles such that about 90% or more of the particles are less than about 325 mesh, U.S. Standard mesh size, or such that the particles have an mean particle size of less than about 50 ⁇ m, significantly improves the sustained release profile of a wide array of opioid compounds inco ⁇ orated into a polymeric matrix, in particular a hydrophilic matrix.
- a further aspect of the present invention therefore comprises a novel solid, oral, controlled release dosage form comprising a therapeutically effective amount of an opioid compound, or a salt thereof, between about 30 and 65% of a matrix-forming polymer and between 5 and 15% ionic exchange resin having a mean particle size of less than about 50 ⁇ m and a particle size distribution such that not less than 90% of the particles pass through a 325 mesh sieve, US. Standard Sieve Size.
- strongly acidic cationic exchange resins such as IRP-69 (Rohm & Hass) having a particle size of less than about 325 mesh (U.S. Standard mesh size) and/or a mean particle size of less than about 50 ⁇ m, more preferably less than about 44 ⁇ m, are particularly useful in formulating improved slow-release oxycodone preparations, particularly when an alkylcellulose matrix-former is utilized.
- the formulations of the present invention may include diluents, lubricants, glidants and additives, as known to those of ordinary skill in the art to improve compaction, augment swallowability, decrease gastrointestinal irritation, and generally to improve the pharmaceutical elegance of the final product.
- diluents which may find application in the present formulations are, without limitation, lactose, microcrystalline cellulose, starch and pregelatinized starch, sucrose, compressible sugar and confectioner's sugar, polyethylene glycol, powdered cellulose, calcium carbonate, calcium sulfate, croscarmellose sodium, crospovidone, dextrates, dextrin, dextrose, fructose, glyceryl palmitostearate, kaolin, magnesium aluminum silicate, magnesium carbonate, magnesium oxide, maltodextrin, mannitol, dibasic calcium phosphate, tribasic calcium phosphate, sodium strach glycolate, sorbitol, and hydrogenated vegetable oil (type 1).
- lubricants which may find application in the present formulations are, without limitation, stearic acid, calcium stearate, glyceryl monostearate, glyceryl palmitostearate, hydrogenated castor oil, hydrogenated vegetable oil (type 1), magnesium stearate, sodium stearyl fumarate, talc and zinc stearate.
- Suitable glidants which may find application in the present formulations, are, without limitation, colloidal silicon dioxide, magnesium trisilicate, starch, talc, and tribasic calcium phosphate.
- additives that may find application in the present formulations are, without limitation, colorants, flavorants, sweetners, granulating agents, and coating agents such as cellulose acetate phthalate.
- a formulation of the present invention may comprise from about 0.1 - 500 mg opioid compound, a matrix-forming polymer from about 10 - 95% w/w, an ion exchange resin from about 0.1 - 50%> w/w, a diluent from about 0 -100% w/w, a glidant from about 0 - 5% w/w and a lubricant from about 0 - 20%> w/w.
- An advantage of the present formulations is that preparation of the formulations typically requires only industry standard equipment.
- Another aspect of the present invention is a process for the preparation of a solid, controlled release, oral dosage form comprising the step of inco ⁇ orating an analgesically effective amount of an opioid analgesic, or salt thereof, in a bulk mixture comprising about 30 to about 65%> of a matrix-forming polymer and about 5 to about 15% of a ionic exchange resin, thereby forming an admixture.
- a process for the preparation of a solid, controlled release, oral dosage form comprising the step of inco ⁇ orating an analgesically effective amount of oxycodone, or a salt thereof, in a bulk mixture comprising about 30 to about 65% of a matrix-forming polymer and about 5 to about 15% of an ionic exchange resin, wherein the dissolution rate in vitro, when measured by the USP Basket Method at 100 ⁇ ra in 900 mL aqueous buffer (pH 1.2 for the first hour and 7.5 for hours 2 through 12) at 37 ° C is between about 5 and 25%> (by weight) oxycodone released over the first hour, between about 16 and 36%» (by weight) oxycodone released after the second hour, between about 40 and 60%) (by weight) oxycodone released after six hours, and between about 60 and 80% (by weight) oxycodone released after twelve hours.
- the release rate is independent of pH between about 1.2 and 7.5. Additionally, the peak plasma level of oxycodone
- Yet another aspect of the present invention relates to methods for reducing the range in daily dosages required to control pain in a human using the formulations described.
- One method comprises administering an oral controlled release dosage form comprising a therapeutically effective amount of an opioid compound, or salt thereof, between 30 and 65% of a matrix-forming polymer and between 5 and 15% ionic exchange resin.
- Another method comprises administering a solid, oral, controlled release dosage form comprising a therapeutically effective amount of oxycodone, or a salt thereof, a matrix- forming polymer and a ionic exchange resin comprising a copolymerization of divinylbenzene.
- the preferred matrix-forming polymer of the present formulations is an alkylcellulose, more preferably a Cj - C 6 hydroxyalkylcellulose.
- the hydroxyalkylcellulose is selected from the group consisting of: hydroxypropylcellulose, hydroxypropylmethyl cellulose and hydroxyethylcellulose.
- the ionic exchange resin of the present invention may be phenolic-based polyamine condensates or styrene-divinylbenzene copolymers, it is preferred that the ionic exchange resin comprise a cationic exchange resin, in particular one which is sulfonated, to maximize charge-charge interactions between the resin and the opioids.
- Cationic exchange resins particularly useful in the present invention may comprise divinylbenzene co-polymers, such as a copolymer of divinylbenzene and styrene, or co-polymer of divinylbenzene and methacrylic acid, and the like. It is preferred that the ionic exchange resin comprise between 5 and 15% of the final dosage form, more preferably between about 7 and 10%>. Preferably the final dosage form contains between about 30 - 65%> matrix-forming polymer, more preferably between about 50 - 60%.
- the matrix-forming polymer, the opioid compound and ionic exchange resin are preferably admixed with one another in dry form, thus decreasing the time and expense involved in the formulation of a final dosage form.
- an oral dosage form is formed by, or in conjunction with, compression and shaping of the admixture. It is preferred, due to the advantageous drug release profile produced thereby, that the ionic exchange resin have a mean particle size of less than about 50 ⁇ m and a particle size distribution such that not less than 90%o of the particles pass through a 325 mesh sieve, U.S. Standard sieve size.
- Preferred opioid compounds useful in the present invention are selected, without limitation, from the group consisting of: buto ⁇ hanol, fentanyl, codeine, dihydrocodeine, hydrocodone bitartrate, hydromo ⁇ hone, meperidine, methadone, mo ⁇ hine, oxycodone hydrochloride, oxymo ⁇ hone, pentazocine, propoxyphene hydrochloride and propoxyphene napsylate.
- the present inventor has in particular discovered that fine particle size resin, having a particle size such that more than about 90%o of the resin particles passes through a 325 mesh screen, U.S. Standard mesh size, significantly improves the sustained release profile of the present formulations as compared to the regular particle size resins (e.g. Amberlite IRP-69M vs. Amberlite IRP-69).
- regular particle size resins e.g. Amberlite IRP-69M vs. Amberlite IRP-69.
- biostudies of formulations using fine particle size resin suggest sustained-release formulations of the present invention may provide abso ⁇ tion equivalent to that obtained with oral oxycodone solutions with lower C max .
- Oxycodone is a semisynthetic narcotic analgesic agent with actions, uses, and side effects similar to those of hydromo ⁇ hone and mo ⁇ hine.
- this highly water soluble compound typically has a half-time of abso ⁇ tion of about 0.4 hours, a half-life of approximately 2 to 3 hours, and a duration of action of approximately 3 to 4 hours.
- the release rate is independent of pH between about 1.2 and
- Oxycodone hydrochloride 10 mg sustained-release dosage forms having the formulations given in Table I below were prepared as follows: oxycodone hydrochoride, USP, lactose NF (Flast Flo), and Amberlite IRP 69M fine particle size cationic exchange resin were run through a No. 20 mesh screen for delumping and were mixed for 10 minutes. Hydroxypropyl methylcellulose, USP, and Cab-O-Sil (M-5) (a glidant) was passed through a No. 20 mesh screen for delumping and then added to the drug powder blend. Mixing of the admixture was performed for 20 minutes. Stearic Acid NF (powder) (a lubricant) was passed through a No. 40 mesh screen and then added to the mixed batch. The batch was subsequently mixed for 3 minutes, the mixer sides wiped, and any adhering powder inco ⁇ orated into the batch. The batch was then mixed for an additional 2 minutes and compressed to form tablets.
- oxycodone hydrochoride USP
- Table 1 The in vitro release rates of formulations 1 - 4 were assessed by the USP Basket Method described hereinabove. Each of the formulations contained a total of 10 mg of oxycodone hydrochloride. The release rate of oxycodone from each of the preparations is set forth below in Table 2.
- Oxycodone hydrochloride 30 mg sustained-release dosage forms having the formulations given in Table 3 were prepared as follows: Lactose NF (Fast Flo) was passed through a No. 20 mesh screen for delumping and was mixed with the D and C Yellow No. 10 Aluminum Lake 6010 and the FD and C Yellow No. 6 Aluminum Lake 5285 for 10 minutes. The lactose/color mix was then milled. Cab-O-Sil (M-5) (a glidant), oxycodone hydrochloride USP and Amberlite IRP-69M fine particle size were passed through a No. 20 mesh screen for delumping and were then mixed with the lactose/color blend for 10 minutes.
- Hydroxypropyl methylcellulose USP Metal K100M (premium) CR
- Stearic acid NF powder
- the batch was mixed for 3 minutes, then the mixer sides and blades were wiped and adhering powder was inco ⁇ orated into the batch.
- the batch was then mixed for an additional 2 minutes and compressed to form tablets.
- formulations 5 and 6 set forth in Table 3, were assessed by the USP Basket Method described hereinabove.
- Each of the formulations contained a total of 30 mg of oxycodone hydrochloride.
- the release rate of the oxycodone from each of the preparations is set forth below in Table 4.
- formulations according to the present invention are also made for tablets having 30 mg, 60 mg and 120 mg of Oxycodone Hydrochloride. Such formulation are set forth in Table 5.
- Oxycodone hydrochloride, USP, Lactose, NF (Fast Flo), and Sodium Polystyrene Sulfonate, USP 27 ⁇ m Fine Particle Size and Methocel K100M (Premium) CR (Hydroxypropyl Methylcellulose, USP) are passed through a #20 mesh screen for delumping and are mixed for 20 minutes.
- the Water, Purified, USP and Alcohol, SDA 23A are added to a tank and mixed. With the mixer running, the granulating fluid is added to the powder blend and the mixture is granulated. The wet mass is passed through a No. 10 mesh screen, placed back into the mixer and dried at 49°C.
- the dried granulation is passed through a mill.
- the Cab-O-Sil (M-5) is passed through a #20 mesh screen for delumping, then added to the drug powder blend and mixed for 5 minutes.
- the Stearic Acid, NF (Powder) is passed through a #40 mesh screen and then added to the batch. The batch is mixed for 5 minutes. Tablets are compressed using 5/16 inch tooling at a weight of 180 mg.
- Oxycodone hydrochloride, USP, Lactose, NF (Fast Flo), and Sodium Polystyrene Sulfonate, USP 27 ⁇ m Fine Particle Size are passed through a #20 mesh screen for delumping and are mixed for 10 minutes in a Bin.
- the Methocel K100M (Premium) CR (Hydroxypropyl Methylcellulose, USP) and Cab-O-Sil (M-5) are passed through a #20 mesh screen for delumping then added to the drug powder blend and mixed for 20 minutes in a Bin.
- the Stearic Acid, NF (Powder) is passed through a #40 mesh screen and then added to the batch. The batch is mixed for 5 minutes. Tablets are compressed using 11/32 inch tooling at a weight of 300 mg.
- Oxycodone Hydrochloride, USP, Sodium Polystyrene Sulfonate, USP 27 ⁇ m Fine Particle Size and Methocel K100M (Premium) CR (Hydroxypropyl Methylcellulose, USP) are passed through a #20 mesh screen for delumping and are mixed for 20 minutes.
- the Water, Purified, USP and Alcohol, SDA 23A are added to a tank and mixed. With the mixer running, the granulating fluid is added to the powder blend and the mixture is granulated.
- the wet mass is passed through a No. 10 mesh screen, placed back into the mixer and dried at 49°C. The dried granulation is passed through a mill.
- the Cab-O-Sil (M-5) is passed through a #20 mesh screen for delumping, then added to the drug powder blend and mixed for 5 minutes.
- the Stearic Acid, NF (Powder) is passed through a #40 mesh screen and then added to the batch. The batch is mixed for 5 minutes. Tablets are compressed using 3/8 inch tooling at a weight of 402 mg.
- Example formulations of Oxycodone Hydrochloride Sustained Release Tablets were prepared using various particle sizes of Amberlite IRP 69. The specific formulations are set forth in Table 7. The function of each ingredient is also described.
- Oxycodone Hydrochloride, USP, Lactose, NF (Fast Flo), and Amberlite IRP 69 Sodium Polystyrene Sulfonate, USP
- the Methocel K100M (Premium) CR (Hydroxypropyl Methylcellulose, USP) and Cab-O-Sil (M-5) are passed through a #20 mesh screen for delumping, then added to the drug powder blend and mixed for 20 minutes.
- the Stearic Acid, NF (Powder) is passed through a #40 mesh screen and then added to the batch. The batch is mixed for 5 minutes. Tablets are compressed using 9/32 inch tooling at a weight of 150 mg.
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Abstract
Description
Claims
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00950755A EP1204406A2 (en) | 1999-07-29 | 2000-07-27 | Opioid sustained-released formulation |
CA002379987A CA2379987A1 (en) | 1999-07-29 | 2000-07-27 | Opioid sustained-released formulation |
AU63813/00A AU6381300A (en) | 1999-07-29 | 2000-07-27 | Opioid sustained-released formulation |
JP2001513391A JP2003522127A (en) | 1999-07-29 | 2000-07-27 | Opioid sustained release formulation |
MXPA02000725A MXPA02000725A (en) | 1999-07-29 | 2000-07-27 | Opioid sustained released formulation. |
US10/085,597 US20020164373A1 (en) | 1999-07-29 | 2002-02-27 | Opioid sustained-released formulation |
US10/657,011 US20040062812A1 (en) | 1999-07-29 | 2003-09-05 | Opioid sustained release formulation |
US11/462,061 US20060263431A1 (en) | 1999-07-29 | 2006-08-03 | Opioid Sustained Release Formulation |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14629899P | 1999-07-29 | 1999-07-29 | |
US60/146,298 | 1999-07-29 |
Publications (2)
Publication Number | Publication Date |
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WO2001008661A2 true WO2001008661A2 (en) | 2001-02-08 |
WO2001008661A3 WO2001008661A3 (en) | 2001-03-22 |
Family
ID=22516741
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/020413 WO2001008661A2 (en) | 1999-07-29 | 2000-07-27 | Opioid sustained-released formulation |
Country Status (7)
Country | Link |
---|---|
US (3) | US20020164373A1 (en) |
EP (1) | EP1204406A2 (en) |
JP (1) | JP2003522127A (en) |
AU (1) | AU6381300A (en) |
CA (1) | CA2379987A1 (en) |
MX (1) | MXPA02000725A (en) |
WO (1) | WO2001008661A2 (en) |
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EP1204406A2 (en) | 2002-05-15 |
MXPA02000725A (en) | 2003-07-14 |
JP2003522127A (en) | 2003-07-22 |
AU6381300A (en) | 2001-02-19 |
CA2379987A1 (en) | 2001-02-08 |
US20020164373A1 (en) | 2002-11-07 |
US20060263431A1 (en) | 2006-11-23 |
US20040062812A1 (en) | 2004-04-01 |
WO2001008661A3 (en) | 2001-03-22 |
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