WO1999000373A8 - Derives de benzimidazole - Google Patents

Derives de benzimidazole

Info

Publication number
WO1999000373A8
WO1999000373A8 PCT/JP1998/002885 JP9802885W WO9900373A8 WO 1999000373 A8 WO1999000373 A8 WO 1999000373A8 JP 9802885 W JP9802885 W JP 9802885W WO 9900373 A8 WO9900373 A8 WO 9900373A8
Authority
WO
WIPO (PCT)
Prior art keywords
benzimidazole derivatives
alkyl
general formula
medicines
salts
Prior art date
Application number
PCT/JP1998/002885
Other languages
English (en)
French (fr)
Other versions
WO1999000373A1 (fr
Inventor
Noritsugu Yamasaki
Takafumi Imoto
Teruo Oku
Akira Katayama
Hiroshi Kayakiri
Osamu Onomura
Takahiro Hiramura
Masahiro Nishikawa
Hitoshi Sawada
Original Assignee
Fujisawa Pharmaceutical Co
Noritsugu Yamasaki
Takafumi Imoto
Teruo Oku
Akira Katayama
Hiroshi Kayakiri
Osamu Onomura
Takahiro Hiramura
Masahiro Nishikawa
Hitoshi Sawada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co, Noritsugu Yamasaki, Takafumi Imoto, Teruo Oku, Akira Katayama, Hiroshi Kayakiri, Osamu Onomura, Takahiro Hiramura, Masahiro Nishikawa, Hitoshi Sawada filed Critical Fujisawa Pharmaceutical Co
Priority to IL13367498A priority Critical patent/IL133674A0/xx
Priority to US09/446,749 priority patent/US6420409B1/en
Priority to EP98929723A priority patent/EP1020452A4/en
Priority to CA002294505A priority patent/CA2294505A1/en
Priority to BR9811273-2A priority patent/BR9811273A/pt
Priority to AU79346/98A priority patent/AU748541B2/en
Priority to HU0002324A priority patent/HUP0002324A3/hu
Publication of WO1999000373A1 publication Critical patent/WO1999000373A1/ja
Publication of WO1999000373A8 publication Critical patent/WO1999000373A8/ja
Priority to HK00107463A priority patent/HK1028246A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PCT/JP1998/002885 1997-06-27 1998-06-26 Derives de benzimidazole WO1999000373A1 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
IL13367498A IL133674A0 (en) 1997-06-27 1998-06-26 Benzimidazole derivatives
US09/446,749 US6420409B1 (en) 1997-06-27 1998-06-26 Benzimidazole derivatives
EP98929723A EP1020452A4 (en) 1997-06-27 1998-06-26 benzimidazole derivatives
CA002294505A CA2294505A1 (en) 1997-06-27 1998-06-26 Benzimidazole derivatives
BR9811273-2A BR9811273A (pt) 1997-06-27 1998-06-26 Derivados de benzimidazol
AU79346/98A AU748541B2 (en) 1997-06-27 1998-06-26 Benzimidazole derivatives
HU0002324A HUP0002324A3 (en) 1997-06-27 1998-06-26 Benzimidazole derivatives and pharmaceutical compositions containing them
HK00107463A HK1028246A1 (en) 1997-06-27 2000-11-22 Benzimidazole derivatives

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP9/187696 1997-06-27
JP18769697 1997-06-27
JP7635798 1998-03-25
JP10/76357 1998-03-25

Publications (2)

Publication Number Publication Date
WO1999000373A1 WO1999000373A1 (fr) 1999-01-07
WO1999000373A8 true WO1999000373A8 (fr) 2000-07-20

Family

ID=26417500

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1998/002885 WO1999000373A1 (fr) 1997-06-27 1998-06-26 Derives de benzimidazole

Country Status (15)

Country Link
US (1) US6420409B1 (ja)
EP (1) EP1020452A4 (ja)
KR (1) KR20010014166A (ja)
CN (1) CN1135224C (ja)
AR (1) AR016108A1 (ja)
AU (1) AU748541B2 (ja)
BR (1) BR9811273A (ja)
CA (1) CA2294505A1 (ja)
HK (1) HK1028246A1 (ja)
HU (1) HUP0002324A3 (ja)
IL (1) IL133674A0 (ja)
RU (1) RU2243968C2 (ja)
TR (1) TR199903277T2 (ja)
TW (1) TW453999B (ja)
WO (1) WO1999000373A1 (ja)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2199532C2 (ru) * 1997-06-27 2003-02-27 Фудзисава Фармасьютикал Ко., Лтд. Сульфонамидное соединение
BR9909440A (pt) * 1998-04-06 2000-12-26 Fujisawa Pharmaceutical Co Derivados de indol
EP1132087A4 (en) * 1998-11-13 2002-06-26 Fujisawa Pharmaceutical Co MEDICINE AGAINST POLYCYSTIC OVARY SYNDROME
US6869950B1 (en) 1998-12-24 2005-03-22 Fujisawa Pharmaceutical Co., Ltd. Benzimidazole derivatives
US6432989B1 (en) 1999-08-27 2002-08-13 Pfizer Inc Use of CRF antagonists to treat circadian rhythm disorders
US6525067B1 (en) 1999-11-23 2003-02-25 Pfizer Inc Substituted heterocyclic derivatives
EP1149583A3 (en) * 2000-04-13 2001-11-14 Pfizer Products Inc. Combinations of corticotropin releasing factor antagonists and growth hormone secretagogues
US6821978B2 (en) 2000-09-19 2004-11-23 Schering Corporation Xanthine phosphodiesterase V inhibitors
CA2465893A1 (en) 2001-11-09 2003-05-22 Schering Corporation Polycyclic guanine derivative phosphodiesterase v inhibitors
WO2003047573A1 (fr) * 2001-12-03 2003-06-12 Takeda Chemical Industries, Ltd. Agents pour améliorer l'état de résistance à l'insuline
US20030181461A1 (en) * 2002-01-25 2003-09-25 Lautt Wilfred Wayne Use of phosphodiesterase antagonists to treat insulin resistance
KR101027570B1 (ko) * 2002-05-03 2011-04-06 이스라엘 인스티튜트 포 바이올로지컬 리서치 중추 및 말초 신경계 장애의 치료를 위한 방법 및 조성물, 및 그에 유용한 신규 화합물
AU2003902860A0 (en) * 2003-06-06 2003-06-26 Daicel Chemical Industries, Ltd Benzimidazole compounds
WO2005082414A2 (en) * 2004-03-02 2005-09-09 Astellas Pharma Inc. Concomitant drugs of a sulfonamide and another therapeutic agent
JP2009523816A (ja) * 2006-01-19 2009-06-25 アボット・ラボラトリーズ ２−イミノ−ベンズイミダゾール類
WO2011063339A1 (en) * 2009-11-23 2011-05-26 Cardioxyl Pharmaceuticals, Inc. Nitroxyl donors for the treatment of pulmonary hypertension
CA2782110A1 (en) * 2009-12-07 2011-06-16 Johns Hopkins University N-acyloxysulfonamide and n-hydroxy-n-acylsulfonamide derivatives
JP5832447B2 (ja) 2009-12-07 2015-12-16 ザ ジョンズ ホプキンス ユニバーシティ ビスアシル化ヒドロキシルアミン誘導体
US8987473B2 (en) 2011-01-28 2015-03-24 Sato Pharmaceutical Co., Ltd. Ring-fused compound
US10689354B2 (en) * 2015-12-11 2020-06-23 Teijin Pharma Limited Aminoazole derivative
WO2017192728A1 (en) 2016-05-03 2017-11-09 Virginia Commonwealth University Heteroatom -doped porous carbons for clean energy applications and methods for their synthesis

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE676196C (de) 1936-08-21 1939-05-30 I G Farbenindustrie Akt Ges Verfahren zur Herstellung von Imidazolverbindungen
US3152142A (en) 1962-05-24 1964-10-06 Dow Chemical Co Benzimidazole compounds
FR2291749A1 (fr) 1974-11-20 1976-06-18 Delalande Sa Nouveaux benzimidazoles acetiques, leur procede de preparation et leur application en therapeutique
JPS51133267A (en) 1975-05-08 1976-11-18 Lilly Co Eli Substituted 11sulphonyl benzimidazole
US4179505A (en) 1977-03-30 1979-12-18 Janssen Pharmaceutica N.V. 5-[4-(Diarylmethyl)-1-piperazinylalkyl]benzimidazole derivatives
US4243806A (en) 1979-06-13 1981-01-06 Janssen Pharmaceutica N.V. 5-[4-(Diarylmethyl)-1-piperazinylalkyl]benzimidazole derivatives
GB2053215B (en) 1979-06-25 1983-04-07 May & Baker Ltd Benzimidazole derivatives
JPS625966A (ja) 1985-07-03 1987-01-12 Nippon Shinyaku Co Ltd ベンズイミダゾ−ル誘導体
NZ221729A (en) 1986-09-15 1989-07-27 Janssen Pharmaceutica Nv Imidazolyl methyl-substituted benzimidazole derivatives and pharmaceutical compositions
CA2004911A1 (en) 1988-12-22 1990-06-22 Mitsuaki Ohta 4,5,6,7-tetrahydrobenzimidazole derivatives
DE3928177A1 (de) * 1989-04-08 1991-02-28 Thomae Gmbh Dr K Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0525129A4 (en) 1990-04-13 1993-03-24 Smith-Kline Beecham Corporation Substituted benzimidazoles
US5196444A (en) 1990-04-27 1993-03-23 Takeda Chemical Industries, Ltd. 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
US5703110A (en) 1990-04-27 1997-12-30 Takeda Chemical Industries, Ltd. Benzimidazole derivatives, their production and use
DE4023369A1 (de) * 1990-07-23 1992-01-30 Thomae Gmbh Dr K Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
RU1836357C (ru) 1990-07-23 1993-08-23 Др.Карл Томэ ГмбХ Производные бензимидазола, их изомеры, смеси изомеров, гидраты или их физиологически переносимые соли, обладающие антагонистическими в отношении ангиотензина свойствами
US5594003A (en) 1991-02-06 1997-01-14 Dr. Karl Thomae Gmbh Tetrahydroimidazo[1,2-a]pyridin-2-yl-(benzimidazol-1-yl)-methyl-biphenyls useful as angiotensin-II antagonists
DE4224133A1 (de) * 1992-07-22 1994-01-27 Thomae Gmbh Dr K Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US5602127A (en) 1991-02-06 1997-02-11 Karl Thomae Gmbh (Alkanesultam-1-yl)-benzimidazol-1-yl)-1yl)-methyl-biphenyls useful as angiotensin-II antagonists
US5614519A (en) 1991-02-06 1997-03-25 Karl Thomae Gmbh (1-(2,3 or 4-N-morpholinoalkyl)-imidazol-4-yl)-benizimidazol-1-yl-methyl]-biphenyls useful as angiotensin-II antagonists
SI9210098B (sl) * 1991-02-06 2000-06-30 Dr. Karl Thomae Benzimidazoli, zdravila, ki te spojine vsebujejo, in postopek za njihovo pripravo
US5407835A (en) 1991-07-31 1995-04-18 Abbott Laboratories Reagents and methods for the quantification of amitriptyline or nortriptyline in biological fluids
GB9121776D0 (en) 1991-10-14 1991-11-27 Fujisawa Pharmaceutical Co Benzimidazole derivatives and process for preparation thereof
DE4237557A1 (de) 1992-11-06 1994-05-11 Bayer Ag Substituierte Benzimidazole
JPH0853424A (ja) 1994-08-11 1996-02-27 Kureha Chem Ind Co Ltd ベンズイミダゾールスルホン酸アミド誘導体
GB9423910D0 (en) 1994-11-26 1995-01-11 Pfizer Ltd Therapeutic agents
EA002357B1 (ru) * 1995-12-28 2002-04-25 Фудзисава Фармасьютикал Ко., Лтд. Производные бензимидазола

Also Published As

Publication number Publication date
HK1028246A1 (en) 2001-02-09
CA2294505A1 (en) 1999-01-07
TR199903277T2 (xx) 2000-07-21
HUP0002324A3 (en) 2001-07-30
CN1135224C (zh) 2004-01-21
AU7934698A (en) 1999-01-19
US6420409B1 (en) 2002-07-16
AR016108A1 (es) 2001-06-20
EP1020452A1 (en) 2000-07-19
WO1999000373A1 (fr) 1999-01-07
BR9811273A (pt) 2000-07-18
HUP0002324A2 (hu) 2001-05-28
TW453999B (en) 2001-09-11
RU2243968C2 (ru) 2005-01-10
CN1268123A (zh) 2000-09-27
EP1020452A4 (en) 2003-04-02
IL133674A0 (en) 2001-04-30
KR20010014166A (ko) 2001-02-26
AU748541B2 (en) 2002-06-06

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