WO1998047857A1 - Solid compositions suitable for oral administration comprising l-carnitine or alkanoyl-l-carnitine choline tartrate - Google Patents
Solid compositions suitable for oral administration comprising l-carnitine or alkanoyl-l-carnitine choline tartrate Download PDFInfo
- Publication number
- WO1998047857A1 WO1998047857A1 PCT/IT1998/000080 IT9800080W WO9847857A1 WO 1998047857 A1 WO1998047857 A1 WO 1998047857A1 IT 9800080 W IT9800080 W IT 9800080W WO 9847857 A1 WO9847857 A1 WO 9847857A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- carnitine
- alkanoyl
- salt
- composition
- choline
- Prior art date
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- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 title claims abstract description 34
- QWJSAWXRUVVRLH-LREBCSMRSA-M 2-hydroxyethyl(trimethyl)azanium;(2r,3r)-2,3,4-trihydroxy-4-oxobutanoate Chemical compound C[N+](C)(C)CCO.OC(=O)[C@H](O)[C@@H](O)C([O-])=O QWJSAWXRUVVRLH-LREBCSMRSA-M 0.000 title claims abstract description 6
- 239000008247 solid mixture Substances 0.000 title abstract description 3
- 229960001518 levocarnitine Drugs 0.000 title 2
- 150000003839 salts Chemical class 0.000 claims abstract description 28
- 235000015872 dietary supplement Nutrition 0.000 claims abstract description 13
- 230000000378 dietary effect Effects 0.000 claims abstract description 3
- 239000013589 supplement Substances 0.000 claims abstract description 3
- 239000000203 mixture Substances 0.000 claims description 18
- 239000004480 active ingredient Substances 0.000 claims description 4
- -1 isovaleryl Chemical group 0.000 claims description 4
- RDHQFKQIGNGIED-MRVPVSSYSA-N O-acetyl-L-carnitine Chemical compound CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C RDHQFKQIGNGIED-MRVPVSSYSA-N 0.000 claims description 3
- 239000002775 capsule Substances 0.000 claims description 3
- 229910052739 hydrogen Inorganic materials 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- UFAHZIUFPNSHSL-MRVPVSSYSA-N O-propanoyl-L-carnitine Chemical compound CCC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C UFAHZIUFPNSHSL-MRVPVSSYSA-N 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 239000007910 chewable tablet Substances 0.000 claims description 2
- 239000001257 hydrogen Substances 0.000 claims description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000001589 carboacyl group Chemical group 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 229960001231 choline Drugs 0.000 description 13
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 13
- 235000016709 nutrition Nutrition 0.000 description 10
- 230000001225 therapeutic effect Effects 0.000 description 9
- 235000013350 formula milk Nutrition 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 239000002417 nutraceutical Substances 0.000 description 6
- 235000021436 nutraceutical agent Nutrition 0.000 description 6
- 235000013305 food Nutrition 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 4
- PHIQHXFUZVPYII-UHFFFAOYSA-N carnitine Chemical class C[N+](C)(C)CC(O)CC([O-])=O PHIQHXFUZVPYII-UHFFFAOYSA-N 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 235000013402 health food Nutrition 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 239000001358 L(+)-tartaric acid Substances 0.000 description 3
- 235000011002 L(+)-tartaric acid Nutrition 0.000 description 3
- FEWJPZIEWOKRBE-LWMBPPNESA-N L-(+)-Tartaric acid Natural products OC(=O)[C@@H](O)[C@H](O)C(O)=O FEWJPZIEWOKRBE-LWMBPPNESA-N 0.000 description 3
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 3
- 125000002252 acyl group Chemical group 0.000 description 3
- SGMZJAMFUVOLNK-UHFFFAOYSA-M choline chloride Chemical compound [Cl-].C[N+](C)(C)CCO SGMZJAMFUVOLNK-UHFFFAOYSA-M 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 235000005911 diet Nutrition 0.000 description 3
- 230000037213 diet Effects 0.000 description 3
- 235000013336 milk Nutrition 0.000 description 3
- 239000008267 milk Substances 0.000 description 3
- 210000004080 milk Anatomy 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
- 239000001763 2-hydroxyethyl(trimethyl)azanium Substances 0.000 description 2
- 235000019743 Choline chloride Nutrition 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 206010019280 Heart failures Diseases 0.000 description 2
- 208000017170 Lipid metabolism disease Diseases 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 2
- 239000008116 calcium stearate Substances 0.000 description 2
- 235000013539 calcium stearate Nutrition 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 229960003178 choline chloride Drugs 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000003925 fat Substances 0.000 description 2
- 230000036449 good health Effects 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000000787 lecithin Substances 0.000 description 2
- 229940067606 lecithin Drugs 0.000 description 2
- 235000010445 lecithin Nutrition 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000010606 normalization Methods 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 150000003904 phospholipids Chemical class 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 230000009469 supplementation Effects 0.000 description 2
- 239000000454 talc Substances 0.000 description 2
- 229910052623 talc Inorganic materials 0.000 description 2
- KIZQNNOULOCVDM-UHFFFAOYSA-M 2-hydroxyethyl(trimethyl)azanium;hydroxide Chemical compound [OH-].C[N+](C)(C)CCO KIZQNNOULOCVDM-UHFFFAOYSA-M 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-M 3-carboxy-2,3-dihydroxypropanoate Chemical compound OC(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-M 0.000 description 1
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 206010007559 Cardiac failure congestive Diseases 0.000 description 1
- 206010058892 Carnitine deficiency Diseases 0.000 description 1
- 208000004481 Choline Deficiency Diseases 0.000 description 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 208000004930 Fatty Liver Diseases 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 206010019708 Hepatic steatosis Diseases 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 208000007101 Muscle Cramp Diseases 0.000 description 1
- 208000021642 Muscular disease Diseases 0.000 description 1
- 206010028372 Muscular weakness Diseases 0.000 description 1
- 201000009623 Myopathy Diseases 0.000 description 1
- 229910020939 NaC104 Inorganic materials 0.000 description 1
- 208000018262 Peripheral vascular disease Diseases 0.000 description 1
- 206010038481 Renal necrosis Diseases 0.000 description 1
- 244000258044 Solanum gilo Species 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 1
- 229960004373 acetylcholine Drugs 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000000748 cardiovascular system Anatomy 0.000 description 1
- 229960004203 carnitine Drugs 0.000 description 1
- 229920001429 chelating resin Polymers 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 150000001840 cholesterol esters Chemical class 0.000 description 1
- 229960004874 choline bitartrate Drugs 0.000 description 1
- 208000021752 choline deficiency disease Diseases 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 235000013345 egg yolk Nutrition 0.000 description 1
- 210000002969 egg yolk Anatomy 0.000 description 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 208000010706 fatty liver disease Diseases 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000021474 generally recognized As safe (food) Nutrition 0.000 description 1
- 235000021473 generally recognized as safe (food ingredients) Nutrition 0.000 description 1
- 230000002008 hemorrhagic effect Effects 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000008604 lipoprotein metabolism Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 210000001700 mitochondrial membrane Anatomy 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 208000029372 muscular lipidosis Diseases 0.000 description 1
- 230000036473 myasthenia Effects 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 1
- 238000013379 physicochemical characterization Methods 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 231100000240 steatosis hepatitis Toxicity 0.000 description 1
- 230000016978 synaptic transmission, cholinergic Effects 0.000 description 1
- 208000016505 systemic primary carnitine deficiency disease Diseases 0.000 description 1
- 235000021476 total parenteral nutrition Nutrition 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
- C07C59/255—Tartaric acid
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/40—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton with quaternised nitrogen atoms bound to carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
Definitions
- compositions suitable for oral administration comprising L- carnitine or alkanoyl-L-carnitine choline tartrate
- the present invention relates to stable, non-hygroscopic, pharmacologically acceptable salts of L-carnitine and lower alkanoyl-L- carnitines which favourably lend themselves to the preparation of solid, orally administrable compositions, which are useful not only as pharmaceuticals but also for the "health food” and “nutraceutical” market.
- the present invention also relates to such compositions.
- L-carnitine has been used in the cardiovascular field for the treatment of acute and chronic myocardial ischaemia, angina pectoris, heart failure and cardiac arrhythmias.
- L-carnitine has been administered to chronic uraemics undergoing regular haemodialytic treatment to combat myasthenia and the onset of muscular cramps.
- acetyl-L-carnitine has been used for the treatment of pathological disturbances of the CNS, particularly Alzheimer's disease and diabetic neuropathy; propionyl-L- carnitine has been used for treating peripheral vascular diseases and congestive heart failure.
- the object of the present invention is to provide stable and non- hygroscopic salts of L-carnitine and lower alkanoyl-L-carnitines which are endowed with an enhanced therapeutical and/or nutritional efficacy with respect to their inner salt counterparts.
- the finished products must be packed in hermetically sealed blisters in order to avoid unpleasant consequences due to humidity.
- the former use L-carnitine or nutritional/dietary supplements containing L-carnitine because it facilitates the oxidation of fatty acids and makes a larger amount of energy available to skeletal muscle, thus allowing enhanced performance and giving rise to less accumulation of lactic acid in the athletes' muscles.
- EP 0 434 088 filed December 21 , 1990 discloses the use of the non-hygroscopic L(-)carnitine L(+)tartrare (2: 1 ) (the preparation and physico-chemical characterization of which were, however, described by D. M ⁇ ller and E. Strack in Hoppe Seyler's Z. Physiol. Chem 351, 618-622, April 1972) for the preparation of solid forms suitable for oral administration.
- This salt presents, however, some drawbacks, such as e.g. the release, after prolonged storage, of traces of trimethylamine which give the product an unpleasant fishy odour.
- L(-)-carnitine L(+)- tartrate (2: 1 ) becomes deliquescent at relative humidity slightly exceeding 60%.
- L-(+)-tartaric acid is unable to give non- hygroscopic salts with the alkanoyl-L-carnitines, such as e.g. acetyl-L- carnitine. It should, furthermore, be noticed that tartaric anion is unable by itself to enhance the therapeutic/nutritional value of L-carnitine.
- the aforesaid object of the present invention i.e. to provide novel, pharmacologically acceptable salts of both L-carnitine and lower alkanoyl-L-carnitines which not only are stable and non-hygroscopic but also possess a higher therapeutic and/or nutritional value than the corresponding inner salts, is achieved by the salts of formula (I):
- R is hydrogen or a straight or branched lower alkanoyl having 2-5 carbon atoms.
- choline ( ⁇ -hydroxyethyl)trimethylammonium hydroxide
- foods e.g. egg yolk, liver, soya, wheat germs, peanuts, etc.
- lecithin phosphatidylcholine
- recent studies have demonstrated that certain clinical and pathological conditions give rise to a deficiency of both choline and L-carnitine and that supplementation of the diet with these compounds is beneficial.
- Choline like L-carnitine inner salt, is a highly hygroscopic compound which, when it decomposes, emits an abnoxious fishy odour due to trimethylamine.
- Choline acts as a source of methyl groups for the biosynthesis of other methylated products. It is the precursor of the neurotransmitter acetylcholine. It has been proved that the administration of choline is beneficial in patients suffering from any disorder related to defective cholinergic neurotransmission.
- Choline is also a major component, along with lecithin, of phospholipids and sphingomyelin.
- a choline deficiency causes a whole range of phospholipid abnormalities which express themselves clinically as fatty liver, kidney lesions (haemorrhagic renal necrosis) and impairment of lipoprotein metabolism.
- a diet deficient in choline cholesterol esters and fats accumulate in the liver.
- the present invention also relates to compositions comprising as active principle(s) at least one of the aforesaid non-hygroscopic pharmacologically acceptable salts and, optionally, one or more pharmacologically acceptable excipients and active ingredients which are well-known to the experts in pharmacy and food technology.
- compositions such as tablets, chewable tablets and capsules, which comprise a salt of L-carnitine or alkanoyl-L-carnitine of formula (I) in an amount corresponding to 50-2,000 mg, preferably 100- 1 ,000 mg, of L-carnitine or alkanoyl-L-carnitine inner salt.
- composition for preparing tablets is the following:
- a composition suitable for preparing capsules is the following:
- compositions of the present invention may be used as dietary/nutritional supplements for human use or as fodder supplement for veterinary purposes.
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cosmetics (AREA)
- Fodder In General (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
Description
Claims
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/402,650 US6080786A (en) | 1997-04-18 | 1998-04-04 | Solid compositions suitable for oral administration comprising L-carnitine or alkanoyl-L-carnitine choline tartrate |
CA002286631A CA2286631C (en) | 1997-04-18 | 1998-04-08 | Solid compositions suitable for oral administration comprising l-carnitine or an alkanoyl-l-carnitinecholine tartrate |
BRPI9808908-0A BR9808908B1 (en) | 1997-04-18 | 1998-04-08 | 1-carnitine or alkanoyl-1-carnitine salt, as well as a pharmaceutical or nutritional composition based thereon. |
JP54538898A JP4046361B2 (en) | 1997-04-18 | 1998-04-08 | Solid composition suitable for oral administration comprising L-carnitine or alkanoyl-L-carnitine choline tartrate |
KR1019997009473A KR100562052B1 (en) | 1997-04-18 | 1998-04-08 | Solid compositions suitable for oral administration comprising L-carnitine or alkanoyl-L-carnitine choline tartrate |
AT98917598T ATE208759T1 (en) | 1997-04-18 | 1998-04-08 | SOLID COMPOSITIONS FOR ORAL ADMINISTRATION CONTAINING L-CARNITINE OR ALKANOYL-L-CARNITINE-CHOLINE TARTRATE |
NZ500535A NZ500535A (en) | 1997-04-18 | 1998-04-08 | Solid compositions suitable for oral administration comprising L-carnitine or alkanoyl-L-carnitine choline tartrate |
EP98917598A EP0975581B1 (en) | 1997-04-18 | 1998-04-08 | Solid compositions suitable for oral administration comprising l-carnitine or alkanoyl-l-carnitine choline tartrate |
AU70777/98A AU731223B2 (en) | 1997-04-18 | 1998-04-08 | Solid compositions suitable for oral administration comprising L-carnitine or alkanoyl-L-carnitine choline tartrate |
DK98917598T DK0975581T3 (en) | 1997-04-18 | 1998-04-08 | Suitable solid oral compositions comprising L-carnitine or alkanoyl-L-canitincholine tartrate |
DE69802518T DE69802518T2 (en) | 1997-04-18 | 1998-04-08 | SOLID COMPOSITIONS FOR ORAL ADMINISTRATION CONTAINING L-CARNITINE OR ALKANOYL-L-CARNITINE CHOLINE TARTRATE |
SI9830051T SI0975581T1 (en) | 1997-04-18 | 1998-04-08 | Solid compositions suitable for oral administration comprising l-carnitine or alkanoyl-l-carnitine choline tartrate |
HK00102419A HK1025562A1 (en) | 1997-04-18 | 2000-04-20 | Solid compositions suitable for oral administration comprising l-carnitine choline tartrate |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT97RM000222A IT1291143B1 (en) | 1997-04-18 | 1997-04-18 | SOLID COMPOSITIONS SUITABLE FOR ORAL ADMINISTRATION INCLUDING L-CARNITINE CHOLINE TARTRATE OR AN ALCANOYL L-CARNITINE CHOLINE |
ITRM97A000222 | 1997-04-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1998047857A1 true WO1998047857A1 (en) | 1998-10-29 |
Family
ID=11404982
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IT1998/000080 WO1998047857A1 (en) | 1997-04-18 | 1998-04-08 | Solid compositions suitable for oral administration comprising l-carnitine or alkanoyl-l-carnitine choline tartrate |
Country Status (17)
Country | Link |
---|---|
US (1) | US6080786A (en) |
EP (1) | EP0975581B1 (en) |
JP (1) | JP4046361B2 (en) |
KR (1) | KR100562052B1 (en) |
AT (1) | ATE208759T1 (en) |
AU (1) | AU731223B2 (en) |
BR (1) | BR9808908B1 (en) |
CA (1) | CA2286631C (en) |
DE (1) | DE69802518T2 (en) |
DK (1) | DK0975581T3 (en) |
ES (1) | ES2167889T3 (en) |
HK (1) | HK1025562A1 (en) |
IT (1) | IT1291143B1 (en) |
NZ (1) | NZ500535A (en) |
PT (1) | PT975581E (en) |
SI (1) | SI0975581T1 (en) |
WO (1) | WO1998047857A1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000073258A1 (en) * | 1999-05-28 | 2000-12-07 | Biosalts S.R.L. | Therapeutically and/or nutritionally enhanced derivatives of active ingredients and orally administrable compositions containing same |
WO2001017948A1 (en) * | 1999-09-03 | 2001-03-15 | Biosalts S.R.L. | Non-hygroscopic salts of active ingredients having therapeutical and/or nutritional activities and orally administrable compositions containing same |
EP1103259A1 (en) * | 1999-11-25 | 2001-05-30 | Basf Aktiengesellschaft | Use of y-butyrobetaine salts for the preparation of compositions suitable for human or animal nutrition |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10350140A1 (en) * | 2003-03-28 | 2004-10-14 | Martin Schymura | Fruit gum composition |
BR102016009579A2 (en) * | 2016-04-28 | 2017-10-31 | Geralatex Indl E Coml Prod Agro Florestais | NUTRITIONAL FOOD SUPPLEMENT FORMULATED ON THE BASIS OF PULP OR HUMID WATERMELON FACTOR, MODIFIED BY HYDRATION OR REIDRATING, ALSO KNOWN AS TAPIOCA ATHLETES OR PRACTICERS OF PHYSICAL ACTIVITIES, ITS COMPOSITIONS AND PROCESS |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1153640A (en) * | 1967-04-10 | 1969-05-29 | Soc D Etudes Prod Chimique | A Carnitin Salt |
FR2529545A1 (en) * | 1982-07-02 | 1984-01-06 | Sanofi Sa | New carnitine salts and process for their preparation. |
US4602039A (en) * | 1983-12-28 | 1986-07-22 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Salts of-carnitine and alkanoyl L-carnitines and process for preparing same |
EP0402755A2 (en) * | 1989-06-14 | 1990-12-19 | Lonza Ag | L-carnitine magnesium citrate |
EP0434088A1 (en) * | 1989-12-22 | 1991-06-26 | Lonza Ag | Pharmaceutical compositions containing L-carnitine |
EP0628309A1 (en) * | 1993-05-28 | 1994-12-14 | AVANTGARDE S.p.A. | Use of O-esters of L-carnitine for the treatment of dermatoses |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5001117A (en) * | 1989-03-07 | 1991-03-19 | Pharmacaps, Inc. | Use of lecithin to restore olfaction and taste |
-
1997
- 1997-04-18 IT IT97RM000222A patent/IT1291143B1/en active IP Right Grant
-
1998
- 1998-04-04 US US09/402,650 patent/US6080786A/en not_active Expired - Fee Related
- 1998-04-08 DE DE69802518T patent/DE69802518T2/en not_active Expired - Lifetime
- 1998-04-08 ES ES98917598T patent/ES2167889T3/en not_active Expired - Lifetime
- 1998-04-08 SI SI9830051T patent/SI0975581T1/en unknown
- 1998-04-08 JP JP54538898A patent/JP4046361B2/en not_active Expired - Fee Related
- 1998-04-08 AT AT98917598T patent/ATE208759T1/en not_active IP Right Cessation
- 1998-04-08 NZ NZ500535A patent/NZ500535A/en unknown
- 1998-04-08 EP EP98917598A patent/EP0975581B1/en not_active Expired - Lifetime
- 1998-04-08 KR KR1019997009473A patent/KR100562052B1/en not_active IP Right Cessation
- 1998-04-08 AU AU70777/98A patent/AU731223B2/en not_active Ceased
- 1998-04-08 WO PCT/IT1998/000080 patent/WO1998047857A1/en not_active Application Discontinuation
- 1998-04-08 BR BRPI9808908-0A patent/BR9808908B1/en not_active IP Right Cessation
- 1998-04-08 PT PT98917598T patent/PT975581E/en unknown
- 1998-04-08 CA CA002286631A patent/CA2286631C/en not_active Expired - Fee Related
- 1998-04-08 DK DK98917598T patent/DK0975581T3/en active
-
2000
- 2000-04-20 HK HK00102419A patent/HK1025562A1/en not_active IP Right Cessation
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1153640A (en) * | 1967-04-10 | 1969-05-29 | Soc D Etudes Prod Chimique | A Carnitin Salt |
FR2529545A1 (en) * | 1982-07-02 | 1984-01-06 | Sanofi Sa | New carnitine salts and process for their preparation. |
US4602039A (en) * | 1983-12-28 | 1986-07-22 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Salts of-carnitine and alkanoyl L-carnitines and process for preparing same |
EP0402755A2 (en) * | 1989-06-14 | 1990-12-19 | Lonza Ag | L-carnitine magnesium citrate |
EP0434088A1 (en) * | 1989-12-22 | 1991-06-26 | Lonza Ag | Pharmaceutical compositions containing L-carnitine |
EP0628309A1 (en) * | 1993-05-28 | 1994-12-14 | AVANTGARDE S.p.A. | Use of O-esters of L-carnitine for the treatment of dermatoses |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000073258A1 (en) * | 1999-05-28 | 2000-12-07 | Biosalts S.R.L. | Therapeutically and/or nutritionally enhanced derivatives of active ingredients and orally administrable compositions containing same |
US6703042B1 (en) | 1999-05-28 | 2004-03-09 | Sigma-Tau Industries Farmaceutiche Riunite S.P.A. | Salts of L-carnitine and lower alkanoyl L-carnitine |
WO2001017948A1 (en) * | 1999-09-03 | 2001-03-15 | Biosalts S.R.L. | Non-hygroscopic salts of active ingredients having therapeutical and/or nutritional activities and orally administrable compositions containing same |
US6653504B1 (en) | 1999-09-03 | 2003-11-25 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Non-hygroscopic salts of active ingredients having therapeutical and/or nutritional activities and orally administrable compositions containing same |
EP1103259A1 (en) * | 1999-11-25 | 2001-05-30 | Basf Aktiengesellschaft | Use of y-butyrobetaine salts for the preparation of compositions suitable for human or animal nutrition |
Also Published As
Publication number | Publication date |
---|---|
BR9808908A (en) | 2000-08-01 |
JP2002512613A (en) | 2002-04-23 |
ATE208759T1 (en) | 2001-11-15 |
DK0975581T3 (en) | 2002-03-25 |
AU7077798A (en) | 1998-11-13 |
KR20010006386A (en) | 2001-01-26 |
CA2286631C (en) | 2008-07-08 |
CA2286631A1 (en) | 1998-10-29 |
ITRM970222A1 (en) | 1998-10-18 |
BR9808908B1 (en) | 2011-02-08 |
DE69802518T2 (en) | 2002-05-16 |
KR100562052B1 (en) | 2006-03-17 |
US6080786A (en) | 2000-06-27 |
SI0975581T1 (en) | 2002-06-30 |
HK1025562A1 (en) | 2000-11-17 |
ES2167889T3 (en) | 2002-05-16 |
PT975581E (en) | 2002-04-29 |
EP0975581A1 (en) | 2000-02-02 |
JP4046361B2 (en) | 2008-02-13 |
AU731223B2 (en) | 2001-03-29 |
NZ500535A (en) | 2001-03-30 |
DE69802518D1 (en) | 2001-12-20 |
EP0975581B1 (en) | 2001-11-14 |
IT1291143B1 (en) | 1998-12-29 |
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