WO1998047016A1 - Shifted echo mr method and device - Google Patents
Shifted echo mr method and device Download PDFInfo
- Publication number
- WO1998047016A1 WO1998047016A1 PCT/IB1998/000390 IB9800390W WO9847016A1 WO 1998047016 A1 WO1998047016 A1 WO 1998047016A1 IB 9800390 W IB9800390 W IB 9800390W WO 9847016 A1 WO9847016 A1 WO 9847016A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- gradient
- navigator
- sequence
- signals
- measured
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/565—Correction of image distortions, e.g. due to magnetic field inhomogeneities
- G01R33/56554—Correction of image distortions, e.g. due to magnetic field inhomogeneities caused by acquiring plural, differently encoded echo signals after one RF excitation, e.g. correction for readout gradients of alternating polarity in EPI
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/4806—Functional imaging of brain activation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/50—NMR imaging systems based on the determination of relaxation times, e.g. T1 measurement by IR sequences; T2 measurement by multiple-echo sequences
Definitions
- the invention relates to a method of imaging an object placed in a static magnetic field by means of magnetic resonance (MR), which method comprises the generation of a plurality of sequences, each sequence comprising a) excitation of nuclear spins in a portion of the object, and b) generation of a read gradient and other gradients for measurement of MR signals along a plurality of lines in k-space.
- the sequence furthermore comprising the generation of a first auxiliary gradient before the read gradient and a second auxiliary gradient after the read gradient, the first and the second auxiliary gradients being generated such that the nuclear spins excited in a sequence (n) are rephased in a sequence (n+i) for i ⁇ i
- the method also
- the invention also relates to an apparatus for carrying out such a method.
- a k-space is to be understood as a spatial frequency domain in which an MR signal is measured along a predetermined trajectory and the measured values yield the inverse fourier transformed values of the image of the object.
- the trajectory in the k-space is determined by the time integral of temporary gradient fields over a time interval from the excitation of the nuclear spins to the actual instant of measurement of the MR signal.
- gradients are to be understood as temporary magnetic fields which are superposed on the steady magnetic field and cause a gradient of the static magnetic field in three respective orthogonal directions.
- the gradient in a first direction is denoted as a read gradient
- the gradient in a second direction as a phase-encoding gradient
- the gradient in a third direction as a slice-encoding gradient.
- the known method is a fast imaging method based on gradient recalled echoes of nuclear spins whose excitation and echo formation are not in the same sequence. Furthermore, the known method has an increased sensitivity to variations in the time constant T 2 * of the free induction decay of the MR signal. Therefore, the known method is used in functional MR imaging studies that are based on temporary changes in T 2 * which result from local changes in magnetic susceptibility, for example, local changes in the brain oxygenation state of a human or animal body.
- a drawback of the known method is that image quality is susceptible to motion, such as the heart rhythm, respiration and motion of the human body itself.
- a method in accordance with the invention is characterized in that the method comprises the further steps of generation of a first navigator gradient within each sequence in order to measure a navigator MR signal; determination of a phase correction from the navigator MR signals measured in order to correct the MR signals measured, and correction of the MR signals measured.
- the susceptibility of the image quality to motion is thus reduced.
- the invention is based on the insight that the image quality is dependant on phase errors in successive MR signals. Motion of the body forms a substantial contribution to these phase errors.
- the motion induced phase errors are due to a long period of time elapsing between the excitation of the nuclear spins in the portion of the body in the first sequence and the measurement of the MR signal relating to that excitation in the further sequence. Furthermore, the motion related phase error of the navigator MR signal and the phase error of the MR signal are correlated. Therefore, the correction of phase errors of the measured MR signals can be determined from the phases of navigator MR signals measured. Navigator MR signals are known per se from US 4,937,526. In the method according to that patent one or more navigator MR signals are produced during the acquisition of the MR signals. From the navigator MR signals corrective operators are derived to reduce motion artefacts.
- a particular version of the method in accordance with the invention is characterised in that the first navigator gradient in the sequence is generated after the first auxiliary gradient and before the read gradient.
- the effect of the generation of the first navigator gradient after the first auxiliary gradient is that phase errors due to the generation of the large first auxiliary gradient will not contribute to a phase difference between the navigator MR signal and the MR signal and therefore the phase error of the MR signal can be determined more accurately.
- a further version of the method in accordance with the invention is characterized in that a first lobe of the read gradient is generated according to a function f(t), and the first navigator gradient is generated according to a function -f(t).
- a further embodiment of the method in accordance with the invention is characterised in that the sequence also comprises the generation of a second navigator gradient in order to measure a further navigator MR signal, the first navigator gradient being generated before the read gradient, whereas the second navigator gradient is generated after the read gradient and before the second auxiliary gradient.
- the effect of this measure is that the image quality is improved more than expected in comparison with a single navigator gradient.
- An explanation of this effect is that phase errors due to an a priori unknown source can be determined more accurately. Examples of a priori unknown sources of phase errors are motion of the body or field deviations in the static magnetic field.
- a further advantage is that the accuracy of determination of the phase corrections is improved because phase errors due to the second auxiliary gradient are not accumulated in the phase errors between the measured first and second navigator MR signals.
- a further version of the method in accordance with the invention is characterised in that the second navigator gradient is generated according to the function -f(t) of the first navigator gradient.
- identical sampling techniques can be used again for the navigator MR signal as well as for the MR signals, for example, the sampling period of the navigator MR signal can be extended to the slopes of the navigator gradient. Therefore the phase correction can be determined more accurately.
- a further version of the method in accordance with the invention is characterised in that a phase correction determined for the MR signal relating to a centre region of the k-space is used for the correction of the MR signals measured within the sequence.
- Other known phase correction techniques for MR signals measured during EPI techniques can thus be employed.
- An example of such echo shifted phase correction is known from US 5,270,654.
- phase correction a step- wise function of the phase error as a function of the k y - values is adapted to a linear function of the k y - value by shifting the instant of rephasing of the nuclear spins with respect to the excitation RF-pulse. That phase correction results in a reduction of ghost-like artefacts in the reconstructed image.
- phase correction is determined by linear correction of the navigator MR signals measured.
- ⁇ mr0 (x) ⁇ mrl (x) ⁇ 0 - — ⁇ — , wherein
- ⁇ mr0 (x) represents the corrected phase
- ⁇ mrI (x) represents the phase of a sample x of the MR signal measured within the further sequence
- ⁇ 0 represents the first correction value based on the measured navigator signals measured within the first and further sequences
- ⁇ ,(x) represents a first correction function based on the measured navigator MR signals within the first and further sequences.
- a further version of the method in accordance with the invention is characterised in that the phase correction is determined by non-linear correction based of the navigator MR signals measured.
- the result of the non-linear correction is that a sample i of the MR signals is corrected with the phase correction determined from corresponding samples i of navigator MR signals measured within the first and further sequences, respectively.
- An example of such a non-linear correction is given by formula ⁇ mr ⁇ t ⁇ ' ⁇ mr My ⁇ t ⁇ ' wherein represents the phase of a sample x of the corrected MR signal and ⁇ mr ,(x) represents the MR signal measured within the further sequence.
- An embodiment of an MR device is characterized in that the control unit is arranged such that each sequence also comprises the generation of a first navigator gradient to measure a navigator MR signal; and that the MR-apparatus also comprises: means for determinating a phase correction from the navigator MR signals measured for correction of the MR signals measured, and means for correcting the MR signals measured.
- Fig. 1 shows an embodiment of an MR apparatus
- Fig. 2 shows two echo shifted EPI sequences, each comprising a navigator gradient
- Fig. 3 shows two echo shifted EPI sequences, each comprising first and second navigator gradients.
- Fig. 1 shows an embodiment of an MR apparatus 1.
- the MR apparatus 1 comprises a first magnet system 2 for generating a steady magnetic field.
- the z-direction of the coordinate system shown corresponds to the direction of the steady magnetic field in the magnet system 2.
- the MR apparatus also comprises a second magnet system 3 for generating temporary magnetic fields directed in the z-direction and gradients in the x,y and z direction, respectively.
- x,y and z are used for the frequency encode, phase encode and selection direction, respectively. These directions do not have to coincide wit the main directions of the system.
- the temporary gradient fields having a gradient in the x-direction, the y-direction and the z- direction are referred to as read gradient, phase-encode gradient and slice-selection gradient, respectively.
- Power supply means 4 feed the second magnet system 3.
- the magnet system 2 encloses an examination space which is large enough to accommodate a part of an object 7 to be examined, for example a part of a human body.
- An RF transmitter coil 5 serves to generate RF magnetic fields and is connected via a transmitter/receiver circuit 9 to an RF source and modulator 6.
- the RF transmitter coil 5 is arranged around the part of the body 7 within the examination space.
- the MR apparatus also comprises a receiver coil which is connected via the transmitter/receiver circuit 9 to a signal amplification and demodulation unit 10.
- the receiver coil and the RF transmitter coil 5 may be one and the same coil.
- a control unit 11 controls the modulator 6 and the power supply means 4 in order to generate imaging sequences comprising RF-pulses and temporary magnetic gradient fields. After excitation of nuclear spins in a part of the body placed within the examination space, the receiver coil 5 receives an MR signal. The phase and amplitude derived therefrom are sampled and further processed in the amplification and demodulation unit 10.
- An image reconstruction unit 12 processes the signals presented so as to form an image. Via an image processing unit 13 this image is displayed, for example on a monitor 14.
- the control unit 11 also controls the image reconstruction unit 12, and the image processing unit 13.
- the invention will be explained, by way of example, on the basis of a shifted echo Planar Imaging sequence (EPI).
- EPI shifted echo Planar Imaging sequence
- Fig. 2 shows a first sequences 20 and a further, second sequence 30, each comprising a navigator gradient.
- the first and second sequences 20,30 comprise an RF- excitation pulse, gradients G x ,G y ,G z and auxiliary gradients G aux .
- the sequences 20,30 are repeated with a period T R .
- the shifted echo EPI sequence 20,30 commences with the application of RF-excitation pulses 100, 101 having a flip angle ⁇ and slice selection gradients 110,111 to excite nuclear spins within a slice of interest of the body 7.
- the flip angle is, for example, 90°.
- first auxiliary gradients 170,172 are generated.
- the first auxiliary gradients 170, 172 are also referred to as crusher gradients and are used to dephase any gradient-recalled MR signals of nuclear spins that are excited in the same sequences.
- the second auxiliary gradients 171, 173 are generated after the read gradient 155,162 at the end of the sequences 20,30.
- the polarity of the second auxiliary gradient 171 opposes that of the first auxiliary gradient 170 in order to rephase in the second sequence 30 the spins excited by the RF-excitation pulse 100 in the first sequence 20.
- the auxiliary gradients 170,172 are generated before the initial phase encoding gradient 120 and the initial phase encoding gradient 126, respectively.
- the auxiliary gradients 170-173 are generated by applying both gradients in the y-direction and the z-direction.
- phase-encoding gradients 121- 124, 127-130 are applied after the lobes of the read gradient 151- 154,158-161 .
- the number of parallel lines in the k-space is, for example, 64, 128 or 256.
- first navigator gradients 150, 157 are generated within the first and second sequences 20,30.
- the first navigator gradients are generated such that if the first lobe 151, 157 of the read gradient is generated according to a function f(t), the navigator gradients 150, 157 are generated according to a function -f(t).
- the navigator gradients 150, 157 are applied after the first auxiliary gradients 170, 172 and before the initial phase encoding gradients 120,126.
- Navigator MR signals 180, 187 are measured during the first navigator gradient 150,157 within the first sequence 20 and the second sequence 30.
- the navigator MR signal measured within the first sequence 20 serves as a reference navigator MR signal for the determination of the phase correction for MR signals 188-192 measured in the subsequent second sequence 30.
- arrays are obtained by application of one-dimensional Fourier transformations, which arrays contain the phases as a function of the distance in the direction of the navigator gradients 150.
- the measured MR signals 181-185 are also transformed by a one-dimensional Fourier transformation so as to obtain arrays ⁇ ,( ⁇ m-/ M) containing the phases as a function of the distance in the direction of the read gradient.
- the x-direction corresponds to both the direction of the navigator gradient and the direction of the read gradient.
- a phase correction is determined in order to correct the array of phases ⁇ ,( ⁇ mr ( )) of the measured MR signals i.
- the phase correction is determined by employing a linear correction or a non-linear correction based on the navigator signals 180, 187 measured within the first and the second sequence, respectively.
- a linear phase correction based on a zero-order interpolation is given by the formula wherein ⁇ mr0 (x) represents the corrected phase, ⁇ mrl ( ⁇ ) represents the phase of a sample x of the measured MR signal i within the second sequence 30, and ⁇ 0 represents a first correction value calculated from the navigator MR signals 180,187, measured within the first and second sequences 20,30 respectively and is given by: x*N
- N represents the number of samples of the na/igator MR signal 180 stored in the arra Y *» * / •
- the first correction function ⁇ ,( ) is also based on the navigator MR signals 180, 187 measured within the first and second sequences 20,30 respectively and is determined by
- said phase corrections do not alter the modulus of the measured MR signal.
- a second navigator gradient is generated within each sequence. That second version is described in relation to Fig 3.
- Fig. 3 shows a third and a fourth echo shifted EPI sequence 40,50, each sequence 40,50 comprising first and second navigator gradients.
- excitation RF pulses 100, 101 slice selection gradients 110, 111 , phase encoding gradients 120-125 , 126- 131 , read gradients 151-155, 158-162, auxiliary gradients 170-173 and first navigator gradients 150, 157 are also generated analogously to the corresponding gradients in the first and second sequences 20,30 as described in relation to Fig.2.
- second navigator gradients 156, 163 are generated for the measurement of further navigator MR signals 186, 193 in the third and fourth sequences 40,50 such that if the first lob 151 , 157 of the read gradient is generated according to a function f(t), the first navigator gradients 150, 157 and the second navigator gradients 156, 163 are generated according to a function -f(t). Furthermore, the second navigator gradients 156, 163 are generated after the last lobes 156, 162 of the read gradient and before the second auxiliary gradients 171 , 173.
- a phase correction for the MR signals 188- 193 measured within the fourth sequence 50 in which the first and second navigator gradients 157, 163 have been generated can be determined from the measured navigator signals 180, 187, 193 by linear correction as well as non-linear correction.
- the second correction function ⁇ .(x) is determined by ⁇ (x)- .x , ⁇ x wherein
- ⁇ 0 represents the second correction value calculated from the navigator MR signals 187, 193 measured within the fourth sequence 50.
- Executing of the phase correction on the measured MR signals, stored in successive arrays yields a set of corrected MR signals.
- the image can be reconstructed from the corrected set of MR signals by using a further one-dimensional Fourier transformation.
- a correction determined for MR signal 159, measured during the lobe 160 of the read gradient corresponding to a central region in the k-space, is also employed to correct each of the other measured MR signals 188,189,191, 192, measured during the other lobes
- phase correction a step-wise function of the phase error as a function of the k y -values is adapted to a linear function of the k y - value by shifting the read gradient with respect to the excitation RF-pulse. This phase correction reduces ghost-like artefacts in the reconstructed image.
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Engineering & Computer Science (AREA)
- Signal Processing (AREA)
- High Energy & Nuclear Physics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Abstract
The invention relates to a fast imaging method based on gradient recalled echoes of nuclear spins whose excitation and echo formation are not contained in the same sequence. The method has an increased susceptibility to variations in the time constant T2* of the free induction decay of the MR signal and is used in, for example, functional MR imaging studies that are based on temporary changes in T2* which are caused by local changes in magnetic susceptibility e.g. local changes in brain oxygenation state of a human or animal body. In order to reduce the susceptibility of the image quality to motion navigator, gradients are generated in each sequence so as to measure a navigator MR signal. From the measured navigator signals a phase correction is determined and the MR signals measured are corrected by means of this phase correction. The invention is based on the insight that the image quality is dependent on phase errors in successive MR signals and that motion of the body makes a substantial contribution to these phase errors. Furthermore, the motion-related phase error of the navigator MR signal and the phase error of the MR signal are correlated. Therefore, the correction of phase errors of the measured MR signals can be determined from the phases of navigator MR signals measured.
Description
Shifted echo MR method and device
The invention relates to a method of imaging an object placed in a static magnetic field by means of magnetic resonance (MR), which method comprises the generation of a plurality of sequences, each sequence comprising a) excitation of nuclear spins in a portion of the object, and b) generation of a read gradient and other gradients for measurement of MR signals along a plurality of lines in k-space. the sequence furthermore comprising the generation of a first auxiliary gradient before the read gradient and a second auxiliary gradient after the read gradient, the first and the second auxiliary gradients being generated such that the nuclear spins excited in a sequence (n) are rephased in a sequence (n+i) for i≥i , the method also
comprising the reconstruction of an image of the portion of the body from the MR signals measured.
The invention also relates to an apparatus for carrying out such a method.
Such a method is known from the article "A Fast Gradient-Recalled MRI Technique with Increased Sensitivity to Dynamic Susceptibility Effects by C.T.W Moonen et al, Magnetic Resonance in Medicine, Vol 26, 1992, page 184-189. It is to be noted that in the context of the present Patent Application a k-space is to be understood as a spatial frequency domain in which an MR signal is measured along a predetermined trajectory and the measured values yield the inverse fourier transformed values of the image of the object. The trajectory in the k-space is determined by the time integral of temporary gradient fields over a time interval from the excitation of the nuclear spins to the actual instant of measurement of the MR signal. Furthermore, gradients are to be understood as temporary magnetic fields which are superposed on the steady magnetic field and cause a gradient of the static magnetic field in three respective orthogonal directions. Generally speaking, the gradient in a first direction is denoted as a read gradient, the gradient in a second direction as a phase-encoding gradient and the gradient in a third direction as a slice-encoding
gradient.
The known method is a fast imaging method based on gradient recalled echoes of nuclear spins whose excitation and echo formation are not in the same sequence. Furthermore, the known method has an increased sensitivity to variations in the time constant T2 * of the free induction decay of the MR signal. Therefore, the known method is used in functional MR imaging studies that are based on temporary changes in T2 * which result from local changes in magnetic susceptibility, for example, local changes in the brain oxygenation state of a human or animal body.
A drawback of the known method is that image quality is susceptible to motion, such as the heart rhythm, respiration and motion of the human body itself.
It is inter alia an object of the invention to reduce the susceptibility of the image quality to motion. To this end, a method in accordance with the invention is characterized in that the method comprises the further steps of generation of a first navigator gradient within each sequence in order to measure a navigator MR signal; determination of a phase correction from the navigator MR signals measured in order to correct the MR signals measured, and correction of the MR signals measured. The susceptibility of the image quality to motion is thus reduced. The invention is based on the insight that the image quality is dependant on phase errors in successive MR signals. Motion of the body forms a substantial contribution to these phase errors. The motion induced phase errors are due to a long period of time elapsing between the excitation of the nuclear spins in the portion of the body in the first sequence and the measurement of the MR signal relating to that excitation in the further sequence. Furthermore, the motion related phase error of the navigator MR signal and the phase error of the MR signal are correlated. Therefore, the correction of phase errors of the measured MR signals can be determined from the phases of navigator MR signals measured. Navigator MR signals are known per se from US 4,937,526. In the method according to that patent one or more navigator MR signals are produced during the acquisition of the MR signals. From the navigator MR signals corrective operators are derived to reduce motion artefacts.
A particular version of the method in accordance with the invention is characterised in that the first navigator gradient in the sequence is generated after the first auxiliary gradient and before the read gradient. The effect of the generation of the first navigator gradient after the first auxiliary gradient is that phase errors due to the generation
of the large first auxiliary gradient will not contribute to a phase difference between the navigator MR signal and the MR signal and therefore the phase error of the MR signal can be determined more accurately.
A further version of the method in accordance with the invention is characterized in that a first lobe of the read gradient is generated according to a function f(t), and the first navigator gradient is generated according to a function -f(t). The result of this measure is that identical sampling techniques can be used for the navigator MR signal as well as for the MR signals, for example, the sampling period of the MR signal can be extended to the slopes of the read gradient. A phase error can thus be determined more accurately. A further embodiment of the method in accordance with the invention is characterised in that the sequence also comprises the generation of a second navigator gradient in order to measure a further navigator MR signal, the first navigator gradient being generated before the read gradient, whereas the second navigator gradient is generated after the read gradient and before the second auxiliary gradient. Surprisingly, the effect of this measure is that the image quality is improved more than expected in comparison with a single navigator gradient. An explanation of this effect is that phase errors due to an a priori unknown source can be determined more accurately. Examples of a priori unknown sources of phase errors are motion of the body or field deviations in the static magnetic field. A further advantage is that the accuracy of determination of the phase corrections is improved because phase errors due to the second auxiliary gradient are not accumulated in the phase errors between the measured first and second navigator MR signals.
A further version of the method in accordance with the invention is characterised in that the second navigator gradient is generated according to the function -f(t) of the first navigator gradient. As a result of this measure identical sampling techniques can be used again for the navigator MR signal as well as for the MR signals, for example, the sampling period of the navigator MR signal can be extended to the slopes of the navigator gradient. Therefore the phase correction can be determined more accurately.
A further version of the method in accordance with the invention is characterised in that a phase correction determined for the MR signal relating to a centre region of the k-space is used for the correction of the MR signals measured within the sequence. Other known phase correction techniques for MR signals measured during EPI techniques can thus be employed. An example of such echo shifted phase correction is known from US 5,270,654. According to that phase correction a step- wise function of the phase error as a function of the ky- values is adapted to a linear function of the ky- value by shifting
the instant of rephasing of the nuclear spins with respect to the excitation RF-pulse. That phase correction results in a reduction of ghost-like artefacts in the reconstructed image.
A further version of the method in accordance with the invention is characterised in that the phase correction is determined by linear correction of the navigator MR signals measured. The phase correction is determined by a zero-order interpolation formula φmr0(x)=φmrl(x)-φ0 , wherein φmr0(x) represents the corrected phase, φmrl(x)
represents the phase of a sample x of the measured MR signal, and φ0 represents a first correction value based on the corrected phase
of tire navigator MR signals of the first and further sequences. Another possibility for linear correction is δφ.(x) determined by a first order interpolation formula Φmr0(x)=Φmrl(x)~Φ0- — ^ — , wherein
φmr0(x) represents the corrected phase, φmrI(x) represents the phase of a sample x of the MR signal measured within the further sequence, φ0 represents the first correction value based on the measured navigator signals measured within the first and further sequences, and φ,(x) represents a first correction function based on the measured navigator MR signals within the first and further sequences.
A further version of the method in accordance with the invention is characterised in that the phase correction is determined by non-linear correction based of the navigator MR signals measured. The result of the non-linear correction is that a sample i of the MR signals is corrected with the phase correction determined from corresponding samples i of navigator MR signals measured within the first and further sequences, respectively. An example of such a non-linear correction is given by formula Φmrϋtø'ΦmrMyΦtø ' wherein
represents the phase of a sample x of the corrected MR signal and Φmr,(x) represents the MR signal measured within the further sequence.
An embodiment of an MR device according to the invention is characterized in that the control unit is arranged such that each sequence also comprises the generation of a first navigator gradient to measure a navigator MR signal; and that the MR-apparatus also comprises: means for determinating a phase correction from the navigator MR signals measured for correction of the MR signals measured, and means for correcting the MR signals measured.
These and other aspects of the invention will be apparent from and elucidated with reference to the embodiments described hereinafter.
In the drawing:
Fig. 1 shows an embodiment of an MR apparatus, Fig. 2 shows two echo shifted EPI sequences, each comprising a navigator gradient, and
Fig. 3 shows two echo shifted EPI sequences, each comprising first and second navigator gradients.
Fig. 1 shows an embodiment of an MR apparatus 1. The MR apparatus 1 comprises a first magnet system 2 for generating a steady magnetic field. The z-direction of the coordinate system shown corresponds to the direction of the steady magnetic field in the magnet system 2. The MR apparatus also comprises a second magnet system 3 for generating temporary magnetic fields directed in the z-direction and gradients in the x,y and z direction, respectively. It is to be noted that for ease of argument x,y and z are used for the frequency encode, phase encode and selection direction, respectively. These directions do not have to coincide wit the main directions of the system. Furthermore, in this Application the temporary gradient fields having a gradient in the x-direction, the y-direction and the z- direction are referred to as read gradient, phase-encode gradient and slice-selection gradient, respectively. Power supply means 4 feed the second magnet system 3. The magnet system 2 encloses an examination space which is large enough to accommodate a part of an object 7 to be examined, for example a part of a human body. An RF transmitter coil 5 serves to generate RF magnetic fields and is connected via a transmitter/receiver circuit 9 to an RF source and modulator 6. The RF transmitter coil 5 is arranged around the part of the body 7 within the examination space. The MR apparatus also comprises a receiver coil which is connected via the transmitter/receiver circuit 9 to a signal amplification and demodulation unit 10. The receiver coil and the RF transmitter coil 5 may be one and the same coil. A control unit 11 controls the modulator 6 and the power supply means 4 in order to generate imaging sequences comprising RF-pulses and temporary magnetic gradient fields. After excitation of nuclear spins in a part of the body placed within the examination space, the receiver coil 5 receives an MR signal. The phase and amplitude derived therefrom are
sampled and further processed in the amplification and demodulation unit 10. An image reconstruction unit 12 processes the signals presented so as to form an image. Via an image processing unit 13 this image is displayed, for example on a monitor 14. The control unit 11 also controls the image reconstruction unit 12, and the image processing unit 13. The invention will be explained, by way of example, on the basis of a shifted echo Planar Imaging sequence (EPI).
Fig. 2 shows a first sequences 20 and a further, second sequence 30, each comprising a navigator gradient. The first and second sequences 20,30 comprise an RF- excitation pulse, gradients Gx,Gy,Gz and auxiliary gradients Gaux. The sequences 20,30 are repeated with a period TR. The shifted echo EPI sequence 20,30 commences with the application of RF-excitation pulses 100, 101 having a flip angle α and slice selection gradients 110,111 to excite nuclear spins within a slice of interest of the body 7. The flip angle is, for example, 90°. After the slice selection, first auxiliary gradients 170,172 are generated. The first auxiliary gradients 170, 172 are also referred to as crusher gradients and are used to dephase any gradient-recalled MR signals of nuclear spins that are excited in the same sequences. The second auxiliary gradients 171, 173 are generated after the read gradient 155,162 at the end of the sequences 20,30. In this example, the polarity of the second auxiliary gradient 171 opposes that of the first auxiliary gradient 170 in order to rephase in the second sequence 30 the spins excited by the RF-excitation pulse 100 in the first sequence 20. Preferably, the auxiliary gradients 170,172 are generated before the initial phase encoding gradient 120 and the initial phase encoding gradient 126, respectively. Furthermore, the auxiliary gradients 170-173 are generated by applying both gradients in the y-direction and the z-direction.
In order to measure the MR signals 181-185, 188-192 along a plurality of parallel lines which are regularly distributed in the k-space and extend parallel to the kx-axis, during the measurement of the MR signals the initial phase-encoding gradients 120, 126 and the read gradients 151-155,158-162 are applied. Furthermore, phase-encoding gradients 121- 124, 127-130, referred to as blips, are applied after the lobes of the read gradient 151- 154,158-161 . The number of parallel lines in the k-space is, for example, 64, 128 or 256. In order to obtain a complete set of measured MR signals for the reconstruction of an image of the region of the body the echo shifted EPI sequence is repeated for different values of the initial phase-encoding gradients 120, 126. For the sake of simplicity, the method according to the invention is elucidated for only one subsequent second sequence. To compensate for phase fluctuations in the measured MR signals in a first
version of the method first navigator gradients 150, 157 are generated within the first and second sequences 20,30. Preferably, the first navigator gradients are generated such that if the first lobe 151, 157 of the read gradient is generated according to a function f(t), the navigator gradients 150, 157 are generated according to a function -f(t). Furthermore, the navigator gradients 150, 157 are applied after the first auxiliary gradients 170, 172 and before the initial phase encoding gradients 120,126. Navigator MR signals 180, 187 are measured during the first navigator gradient 150,157 within the first sequence 20 and the second sequence 30. Preferably, the navigator MR signal measured within the first sequence 20 serves as a reference navigator MR signal for the determination of the phase correction for MR signals 188-192 measured in the subsequent second sequence 30. From the measured navigator MR signal 187,187 arrays
are obtained by application of one-dimensional Fourier transformations, which arrays contain the phases as a function of the distance in the direction of the navigator gradients 150. The measured MR signals 181-185 are also transformed by a one-dimensional Fourier transformation so as to obtain arrays Φ,(Φm-/M) containing the phases as a function of the distance in the direction of the read gradient. In this example, the x-direction corresponds to both the direction of the navigator gradient and the direction of the read gradient. From the arrays ΦΠΛ ,Φ„ΠV2 a phase correction is determined in order to correct the array of phases Φ,(φmr ( )) of the measured MR signals i. In order to determine a phase correction for an MR signal i which is due to known sources of phase error in the first version of the method, the phase correction is determined by employing a linear correction or a non-linear correction based on the navigator signals 180, 187 measured within the first and the second sequence, respectively. An example of a linear phase correction based on a zero-order interpolation is given by the formula
wherein φmr0(x) represents the corrected phase, Φmrl(χ) represents the phase of a sample x of the measured MR signal i within the second sequence 30, and φ0 represents a first correction value calculated from the navigator MR signals 180,187, measured within the first and second sequences 20,30 respectively and is given by:
x*N
∑ Φ )-Mnav2(χ) x=\
Φ ■Όθ = " x=N
∑ Mnav2(x) x=\
wherein N represents the number of samples of the na/igator MR signal 180 stored in the arraY *»*/ •
The first correction function φ,( ) is also based on the navigator MR signals 180, 187 measured within the first and second sequences 20,30 respectively and is determined by
An example of a linear phase correction for the MR signal i measured within the second sequence 30 is based on a linear interpolation and given by
An example of non-linear phase correction is given by φmrϋ(x)=φmrl(x)-φ(x) ■ In this type of non-linear phase correction the phase of a sample x of a measured MR signal 190 is corrected by a phase correction pixel-wise determined from the corresponding samples of the navigator MR signals 180, 187 measured within the first and second sequences 20,30, respectively. Furthermore, it is to be noted that said phase corrections do not alter the modulus of the measured MR signal.
Repeating one of the above phase correction on subsequent arrays of measured navigator MR signals and measured MR signals of further subsequent second sequences yields a set of corrected MR signals. An image can then be reconstructed from the corrected set of MR signals by using a further one-dimensional Fourier transformation.
In order to determine phase corrections for MR signals due to a priori unknown sources of phase errors in a second version of the method a second navigator gradient is generated within each sequence. That second version is described in relation to Fig 3. Fig. 3 shows a third and a fourth echo shifted EPI sequence 40,50, each sequence 40,50 comprising first and second navigator gradients. In the third and fourth sequences 40,50 excitation RF
pulses 100, 101 , slice selection gradients 110, 111 , phase encoding gradients 120-125 , 126- 131 , read gradients 151-155, 158-162, auxiliary gradients 170-173 and first navigator gradients 150, 157 are also generated analogously to the corresponding gradients in the first and second sequences 20,30 as described in relation to Fig.2. Furthermore, in the third and fourth sequences 40,50 second navigator gradients 156, 163 are generated for the measurement of further navigator MR signals 186, 193 in the third and fourth sequences 40,50 such that if the first lob 151 , 157 of the read gradient is generated according to a function f(t), the first navigator gradients 150, 157 and the second navigator gradients 156, 163 are generated according to a function -f(t). Furthermore, the second navigator gradients 156, 163 are generated after the last lobes 156, 162 of the read gradient and before the second auxiliary gradients 171 , 173.
In the second version of the method a phase correction for the MR signals 188- 193 measured within the fourth sequence 50 in which the first and second navigator gradients 157, 163 have been generated, can be determined from the measured navigator signals 180, 187, 193 by linear correction as well as non-linear correction.
These kinds of corrections are analogous to the corrections described with reference to Fig.2.
An example of linear phase correction based on the zero-order interpolation is given by the formula ΦmJ7>
' wherein φmr0(x) represents the corrected phase, φmrl(x) represents the phase of a sample x of the measured MR signal, and ψ0 represents a second correction value calculated from the measured navigator MR signals 180, 187, 193 of the third and fourth sequences 40,50, respectively, and is given by
Σ x= l ^W
The second correction function ψ.(x) is determined by ψ(x)- .x , δx wherein
An example of linear phase correction based on linear interpolation is given by
of the MR signal measured within the fourth sequence 50, respectively, and ψ0 represents the second correction value calculated from the navigator MR signals 187, 193 measured within the fourth sequence 50.
An example of a non-linear interpolation is given by the formula
• I this type of non-linear phase correction the phase of a sample x of a MR signal 190 measured within the fourth sequence 50 is corrected by a phase correction pixel-wise determined from the navigator MR signal 180 measured in the third sequence 40 and the navigator MR signals 187,193 measured in the fourth sequences 50. Furthermore, it is to be noted that said phase corrections do not alter the modulus of the measured MR signals.
Executing of the phase correction on the measured MR signals, stored in successive arrays yields a set of corrected MR signals. The image can be reconstructed from the corrected set of MR signals by using a further one-dimensional Fourier transformation.
In order to enable the use of echo shifted EPI phase correction techniques a correction determined for MR signal 159, measured during the lobe 160 of the read gradient corresponding to a central region in the k-space, is also employed to correct each of the other measured MR signals 188,189,191, 192, measured during the other lobes
158, 159,161,162 of the read gradient of the fourth sequence 50. Such an echo-shifted EPI phase correction is known from the cited US 5270654. According to that phase correction a step-wise function of the phase error as a function of the ky-values is adapted to a linear function of the ky- value by shifting the read gradient with respect to the excitation RF-pulse. This phase correction reduces ghost-like artefacts in the reconstructed image.
Table of used symbols
Gx,Gy,Gz gradients in the x,y,and z directions, respectively
Gaux auxiliary gradient Q! flip angle of RF excitation pulse
TR repetition period of the image sequence
Mmvl(x) magnitude of sample x of a first navigator MR signal nβv/W phase of sample x of a navigator MR signal of the first sequence φmv2(x) phase of sample x of a first navigator MR signal in a second sequence Φnav3 ) phase of sample x of a second navigator MR signal in the second sequence
Φmr ) phase of sample x of the measured MR signal in the second sequence φ mro(χ) phase of sample x of the corrected MR signal φ0 first correction value Ό second correction value Φ,(Λ;) first correction function
I ,(J ) second correction function tnπv2 time elapsed between the RF-excitation pulse in the first sequence and the measurement of the first navigator MR signal in the second sequence tmv3 time elapsed between the RF-excitation pulse in the first sequence and the measurement of the second navigator MR signal in the second sequence.
Claims
1. A method of imaging an object placed in a static magnetic field by means of magnetic resonance (MR), which method comprises the generation of a plurality of sequences, each sequence comprising a) excitation of nuclear spins in a portion of the object, and b) generation of a read gradient and other gradients for measurement of MR signals along a plurality of lines in k-space the sequence furthermore comprising the generation of a first auxiliary gradient before the read gradient and a second auxiliary gradient after the read gradient, the first and the second auxiliary gradients being generated such that the nuclear spins excited in a sequence (n) are rephased in a sequence (n+i) for i ≥ 1 , the method also comprising the reconstruction of an image of the portion of the object from the MR signals measured, characterized in that the method comprises the further steps of generation of a first navigator gradient in each sequence in order to measure a navigator MR signal, determination of a phase correction from the navigator MR signals measured in order to correct the MR signals measured, and correction of the MR signals measured.
2. A method as claimed in Claim 1, characterized in that the first navigator gradient in the sequence is generated after the first auxiliary gradient and before the read gradient.
3. A method as claimed in Claim 1 or 2 characterized in that a first lobe of the read gradient is generated according to a function f(t), and the first navigator gradient is generated according to a function -f(t).
4. A method as claimed in Claim 1,2 or 3 characterized in that the sequence also comprises the generation of a second navigator gradient in order to measure a further navigator MR signal, the first navigator gradient being generated before the read gradient, whereas the second navigator gradient is generated after the read gradient and before the second auxiliary gradient.
5. A method as claimed in Claim 4 characterized in that the second navigator gradient is generated according to the function -f(t) of the first navigator gradient.
6. A method as claimed in any of Claims 1-5 characterized in that a phase correction determined for the MR signal relating to a centre region of the k-space is used for the correction of the other MR signals measured within the sequence.
7. A method as claimed in any of Claims 1-6 characterized in that the phase correction is determined by a linear correction of the navigator MR signals measured.
8. A method as claimed in any of Claims 1-7 characterised in that the phase correction is determined by non-linear correction of the navigator MR signals measured.
9. An MR device for the acquisition of images of a region of an object arranged in a substantially uniform steady magnetic field, the MR device comprising; a) a magnet for generating the steady magnetic field, b) means for generating temporary magnetic gradient fields, comprising a read gradient and other temporary gradient fields orthogonal to the read gradient, c) means for generating RF pulses, d) means for measuring MR signals, e) processing means for processing the MR signals measured so as to determine an image of the region of the object, and f) a control unit for generating control signals for the means for generating the temporary gradient fields, and the means for generating the RF pulses, the control unit being arranged such that a plurality of sequences is generated, each sequence comprising generation of RF pulses to excite nuclear spins in a portion of the object, generation of a read gradient and other gradients for measurement of MR signals along a plurality of lines in k-space the sequence furthermore comprising the generation a first auxiliary gradient before the read gradient and a second auxiliary gradient after the read gradient, the first and the second auxiliary gradient being generated such that nuclear spins excited in a sequence (n) are rephased in a sequence (n+i) for / > 1 , characterized in that the control unit is arranged such that each sequence also comprises the generation of a first navigator gradient to measure a navigator MR signal; and that the MR-device also comprises: means for determinating a phase correction from the navigator MR signals measured for correction of the measured MR signals, and means for correcting the MR signals measured.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10529349A JP2000511815A (en) | 1997-04-11 | 1998-03-19 | Shift echo MR method and apparatus |
EP98907089A EP0917654A1 (en) | 1997-04-11 | 1998-03-19 | Shifted echo mr method and device |
PCT/IB1998/000390 WO1998047016A1 (en) | 1997-04-11 | 1998-03-19 | Shifted echo mr method and device |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97201088 | 1997-04-11 | ||
EP97201088.8 | 1997-04-11 | ||
PCT/IB1998/000390 WO1998047016A1 (en) | 1997-04-11 | 1998-03-19 | Shifted echo mr method and device |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1998047016A1 true WO1998047016A1 (en) | 1998-10-22 |
Family
ID=26146360
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB1998/000390 WO1998047016A1 (en) | 1997-04-11 | 1998-03-19 | Shifted echo mr method and device |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP0917654A1 (en) |
WO (1) | WO1998047016A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103513204A (en) * | 2012-06-29 | 2014-01-15 | 西门子(深圳)磁共振有限公司 | Track correction method and device of K space data in magnetic resonance imaging |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4937526A (en) * | 1988-11-23 | 1990-06-26 | Mayo Foundation For Medical Education And Research | Adaptive method for reducing motion and flow artifacts in NMR images |
US5254948A (en) * | 1988-04-01 | 1993-10-19 | Hitachi, Ltd. | Method and apparatus for body motion corrective imaging |
US5581184A (en) * | 1994-12-21 | 1996-12-03 | Siemens Aktiengesellschaft | Method for phase correction of nuclear magnetic resonance signals |
-
1998
- 1998-03-19 EP EP98907089A patent/EP0917654A1/en not_active Withdrawn
- 1998-03-19 WO PCT/IB1998/000390 patent/WO1998047016A1/en not_active Application Discontinuation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5254948A (en) * | 1988-04-01 | 1993-10-19 | Hitachi, Ltd. | Method and apparatus for body motion corrective imaging |
US4937526A (en) * | 1988-11-23 | 1990-06-26 | Mayo Foundation For Medical Education And Research | Adaptive method for reducing motion and flow artifacts in NMR images |
US5581184A (en) * | 1994-12-21 | 1996-12-03 | Siemens Aktiengesellschaft | Method for phase correction of nuclear magnetic resonance signals |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103513204A (en) * | 2012-06-29 | 2014-01-15 | 西门子(深圳)磁共振有限公司 | Track correction method and device of K space data in magnetic resonance imaging |
Also Published As
Publication number | Publication date |
---|---|
EP0917654A1 (en) | 1999-05-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20140070805A1 (en) | Mr imaging with b1 mapping | |
US6472872B1 (en) | Real-time shimming of polarizing field in magnetic resonance system | |
JP5196408B2 (en) | Magnetic resonance spectroscopy of species with multiple peaks. | |
US10247798B2 (en) | Simultaneous multi-slice MRI measurement | |
JPH08275929A (en) | Shim adjusting method for magnetic device of nuclear spin tomographic device,and device to perform said method | |
US11585884B2 (en) | Continual trajectory correction in magnetic resonance imaging | |
US5592091A (en) | Method for shimming a magnetic field in an examination space of a nuclear magnetic resonance apparatus including use of fuzzy logic | |
US6331777B1 (en) | Magnetic resonance method and device | |
US6076006A (en) | Diffusion-weighted MRI method | |
CN107624162B (en) | Magnetic resonance examination system with field probe | |
WO2016180983A1 (en) | Multi-echo mri with correction of concomitant gradient-induced phase errors | |
US5810727A (en) | Method of and device for the imaging of objects by means of magnetic resonance | |
US4616183A (en) | Method for reducing baseline error components in NMR signals | |
US6285900B1 (en) | Method and device for generating a perfusion image of a body portion using magnetic resonance imaging | |
JP7023954B2 (en) | Propeller MR imaging | |
US6489770B1 (en) | Nuclear magnetic resonance imaging apparatus | |
US6057686A (en) | Shifted echo MR method and device | |
US6172502B1 (en) | Method of and device for imaging by means of magnetic resonance | |
EP0910804A1 (en) | Diffusion-weighted mri method | |
US20050036944A1 (en) | Diffusion-weighted parallel imaging with navigator-signal-based phase correction | |
WO1998047016A1 (en) | Shifted echo mr method and device | |
JP3367693B2 (en) | Magnetic resonance apparatus and method for adjusting uniformity of static magnetic field in magnetic resonance apparatus | |
US20200300948A1 (en) | Dixon type water/fat separation mr imaging with improved fat shift correction | |
EP3480617A1 (en) | Diffusion weighted turbo spin echo mr imaging with motion compensation | |
US11681002B2 (en) | Method for recording a magnetic resonance image data set, data carrier, computer-program product, and magnetic resonance system |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): JP |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1998907089 Country of ref document: EP |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWP | Wipo information: published in national office |
Ref document number: 1998907089 Country of ref document: EP |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 1998907089 Country of ref document: EP |