WO1998023727A1 - Lactic ferment comprising a particular strain of lactobacillus acidophilus and use thereof - Google Patents
Lactic ferment comprising a particular strain of lactobacillus acidophilus and use thereof Download PDFInfo
- Publication number
- WO1998023727A1 WO1998023727A1 PCT/CA1997/000915 CA9700915W WO9823727A1 WO 1998023727 A1 WO1998023727 A1 WO 1998023727A1 CA 9700915 W CA9700915 W CA 9700915W WO 9823727 A1 WO9823727 A1 WO 9823727A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- dairy product
- strain
- fermented dairy
- infections
- lactobacillus acidophilus
- Prior art date
Links
- 240000001046 Lactobacillus acidophilus Species 0.000 title claims abstract description 19
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 title claims abstract description 19
- 229940039695 lactobacillus acidophilus Drugs 0.000 title claims abstract description 19
- 235000013365 dairy product Nutrition 0.000 claims abstract description 19
- 230000000694 effects Effects 0.000 claims abstract description 9
- LWGJTAZLEJHCPA-UHFFFAOYSA-N n-(2-chloroethyl)-n-nitrosomorpholine-4-carboxamide Chemical compound ClCCN(N=O)C(=O)N1CCOCC1 LWGJTAZLEJHCPA-UHFFFAOYSA-N 0.000 claims abstract description 9
- 241000124008 Mammalia Species 0.000 claims abstract description 8
- 238000004519 manufacturing process Methods 0.000 claims abstract description 7
- 244000199866 Lactobacillus casei Species 0.000 claims abstract description 5
- 235000013958 Lactobacillus casei Nutrition 0.000 claims abstract description 5
- 229940017800 lactobacillus casei Drugs 0.000 claims abstract description 5
- 239000003242 anti bacterial agent Substances 0.000 claims abstract description 3
- 229940088710 antibiotic agent Drugs 0.000 claims abstract description 3
- 235000021001 fermented dairy product Nutrition 0.000 claims description 27
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 10
- 239000008280 blood Substances 0.000 claims description 9
- 210000004369 blood Anatomy 0.000 claims description 9
- 238000000855 fermentation Methods 0.000 claims description 8
- 230000004151 fermentation Effects 0.000 claims description 8
- 201000010099 disease Diseases 0.000 claims description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 7
- 244000005700 microbiome Species 0.000 claims description 7
- 208000035473 Communicable disease Diseases 0.000 claims description 6
- 206010012735 Diarrhoea Diseases 0.000 claims description 6
- 208000007784 diverticulitis Diseases 0.000 claims description 6
- 208000015181 infectious disease Diseases 0.000 claims description 6
- 235000013336 milk Nutrition 0.000 claims description 6
- 239000008267 milk Substances 0.000 claims description 6
- 210000004080 milk Anatomy 0.000 claims description 6
- 201000009890 sinusitis Diseases 0.000 claims description 6
- 208000019206 urinary tract infection Diseases 0.000 claims description 6
- 208000011231 Crohn disease Diseases 0.000 claims description 5
- 230000037406 food intake Effects 0.000 claims description 5
- 208000004840 megacolon Diseases 0.000 claims description 5
- 235000013305 food Nutrition 0.000 claims description 3
- 206010022678 Intestinal infections Diseases 0.000 claims 1
- 208000028774 intestinal disease Diseases 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 abstract description 4
- 210000000987 immune system Anatomy 0.000 abstract description 4
- 230000000968 intestinal effect Effects 0.000 abstract description 4
- 230000009286 beneficial effect Effects 0.000 abstract description 3
- 230000003312 cholesterol blood level Effects 0.000 abstract description 3
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 230000009467 reduction Effects 0.000 description 15
- 241000894006 Bacteria Species 0.000 description 10
- 241000186660 Lactobacillus Species 0.000 description 7
- 229940039696 lactobacillus Drugs 0.000 description 6
- 235000012000 cholesterol Nutrition 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 241000282412 Homo Species 0.000 description 4
- 102000004196 processed proteins & peptides Human genes 0.000 description 4
- 108090000765 processed proteins & peptides Proteins 0.000 description 4
- 235000013618 yogurt Nutrition 0.000 description 4
- 241000282414 Homo sapiens Species 0.000 description 3
- 230000029087 digestion Effects 0.000 description 3
- 210000002249 digestive system Anatomy 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 102000014171 Milk Proteins Human genes 0.000 description 2
- 108010011756 Milk Proteins Proteins 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 235000015140 cultured milk Nutrition 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 235000021239 milk protein Nutrition 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 1
- 244000199885 Lactobacillus bulgaricus Species 0.000 description 1
- 235000013960 Lactobacillus bulgaricus Nutrition 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 241000194020 Streptococcus thermophilus Species 0.000 description 1
- 229930003451 Vitamin B1 Natural products 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 201000009840 acute diarrhea Diseases 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000036765 blood level Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000020247 cow milk Nutrition 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 238000007872 degassing Methods 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 229940004208 lactobacillus bulgaricus Drugs 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000001539 phagocyte Anatomy 0.000 description 1
- 230000004526 pharmaceutical effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 235000010374 vitamin B1 Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/123—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt
- A23C9/1234—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt characterised by using a Lactobacillus sp. other than Lactobacillus Bulgaricus, including Bificlobacterium sp.
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/113—Acidophilus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/225—Lactobacillus
- C12R2001/23—Lactobacillus acidophilus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/853—Lactobacillus
- Y10S435/854—Lactobacillus acidophilus
Definitions
- the present invention concerns a purified strain Lactobacillus acidophilus identified as CNCM/l-1 492 (hereinafter called L.a. 1- 1 492), the microorganism from this strain, a lactic ferment comprising this strain, a process for making dairy products using this ferment, and the dairy products obtained by this process and containing at least 500 million per gram of Lactobacillus acidophilus (including the L.a. 1-1 492 strain) or 380 million/gram of L.a. 1-1492.
- L.a. 1- 1 492 a purified strain Lactobacillus acidophilus identified as CNCM/l-1 492
- the invention also concerns the use of a ferment comprising the strain Lactobacillus acidophilus CNCM/l-1 492 and of a dairy product containing the same in the pharmaceutical field for reducing the level of cholesterol in the blood of a mammal.
- Yogurts are fermented dairy products obtained by fermentation of different lactic bacterias with milk.
- the most widely used milk is cow's milk.
- These lactic bacterias mainly Streptococcus thermophilus and Lactobacillus bulgaricus
- These lactic bacterias are foreign bodies to the human intestinal flora and are not implanted in the digestive system during consumption of these dairy products.
- lactic bacterias are present in their natural state in the human digestive system. It seems that the presence of such bacterias are beneficial and helpful in particular to improve the absorption of food while maintaining the equilibrium in the intestinal flora.
- Such other bacterias in particular are Lactobacillus casei and Lactobacillus acidophilus.
- dairy products containing such bacterias are of particular interest inasmuch as they allow better digestion and provide an easier absorption of calcium when the latter is in the presence of moderate amounts of lactose. Indeed, during fermentation, milk protein and sugar are hydrolyzed, thereby falicitating hydrolisation of minerals such as calcium, iron essential to their absorption.
- Lb casei and milk Lb acidophilus have been found effective to rapidly reduce acute diarrhea in humans.
- Lb acidophilus has also been found to have a healing effect on other gastric- intestinal related problems such as diverticulitis, food poisining, abnormal fermentation.
- I- 1492 strain or L.a. 1-1492, has not only a beneficial effect on digestion and the equilibrium of the intestinal tract, but also has a major pharmaceutical effect allowing the reduction of the cholesterol level in the blood of mammals, and more particularly humans.
- the present invention concerns a purified strain Lactobacillus acidophilus 1-1492 (L.a. 1-1492) and the microorganism from this strain.
- This strain can used in a lactic ferment, which is also an object of the invention, comprising a mixture of the following lactic strains:
- Lactobacillus casei strain at least one Lactobacillus casei strain.
- the latter two strains may be of commercial origin and can be purchased from manufacturers of lactic ferments.
- the commercial Lactobacillus acidophilus strain that is used in the ferment of the present invention may be the one sold under the trademark RP Texel by Rh ⁇ ne-Poulenc or the one sold under the trademark L.a. RO-52 by Rosell.
- the commercial Lactobacillus casei strain may be the one sold under the trademark E2AL by Rh ⁇ ne-Poulenc.
- Another object of the invention is a fermented lactic product of the yogurt type obtained by fermentation of the strain or of the lactic ferment according to the invention, with a dairy compound.
- a further object of the invention is a method of manufacturing a fermented dairy product by the fermentation of the ferment according to the invention, said product having the texture of a yogurt.
- a further object of the invention is the use of such fermented dairy product in the stimulation of the immune system for curing sore throat, flu, sinusitis and urinary infection.
- This same fermented dairy product has also been found to be useful in treating gatric-intestinal related diseases and infections.
- Still a further object of the invention is the use of the above dairy products to reduce the cholesterol blood level in mammals, especially humans, and a method of medical treatment comprising the ingestion of a dairy product according to the invention.
- the purified Lactobacillus acidophilus strain 1-1492 according to the invention was filed on November 1 5, 1 994 in the National Collection of Microorganism Cultures (25, Rue du Dr. ROUX, F-75724 Paris Cedex 1 5) according to the provisions of the Budapest Treaty.
- the physiological, chemical and biochemical characteristics of the acidophilus strains that may be used in the ferment according to the invention are shown in tables 1 and 2. It has been found that the L.a. 1-1 492 strain present chemical, biochemical and physiological characteristics similar to those of the other L.a. strains. As a matter of fact, the L.a. 1-1492 strain differs from the others only in that it degrades cholesterol more efficiently.
- Lactobacillus type (Group I): chemical and biochemical characteristics
- the fermenting profile for the L.a. strains which include the L.a. 1-1 492 strain is shown in table 3.
- Lactobacillus type (Groupe II) Chemical and biochemical characteristics
- Lactobacillus type (Group I I): physiological characteristics
- Lactobacillus type (Group II): fermenting profile
- a dairy product according to the present invention can be obtained by fermenting the ferment of the invention in a milk-based medium.
- the following process may be used.
- the L.a. 1-1 492, acidophilus and casei strains are incubated in a MRS type fermentation medium under 10% of CO2 according to a standard program comprising several steps.
- the recombined lacteal base which is partially lactose-free and degassed is pasteurized for 1 ,5 minutes at 95 °C and inoculated at 1 0% .
- it is incubated according to the following program:
- the product is then co-fermented in an anaerobic atmosphere and medium for 1 5 hours at 37 °C (degassing under CO2) .
- any acidophilus and casei strains may be used as long as they present no health risk.
- the following acidophilus strain should be used: RP Texel TM by Rh ⁇ ne-Poulenc and L.a. RO-52 TMby Rosell.
- the commercial casei E2ALTM by Rh ⁇ ne-Poulenc is preferably used.
- L.a. 1-1492 must be at least 380* 10 6 /g.
- the level of peptides comprised in the fermented dairy product having a molecular weight between 1000 and 5000 Da. is around 30% and the level of small peptides having less than 1 0 residues is approximately 1 5% . It is known that such levels of peptides fortify, in a suprising way, the immune and digestive systems.
- the dairy proteins are disintegrated into peptides whose size may be more or less large, allowing for an easier digestion of the product. Indeed, subject allergic to milk proteins were able to digest the fermented dairy product thus obtained.
- the fermented dairy product is manufactured, it is thereafter refrigerated and must be consumed before it deteriorates. Generally, the consumption of the same must take place within a period of 60 to 1 20 days.
- a dairy product according to the invention has been commercialized by the applicant Bio-K PLUS International Inc. (whose address is: 635 Victoria, Westmount, H3Y 2R9, CANADA) since June 2, 1 996, under the trade-mark
- the fermented dairy product according to the invention has a stimulation effect on the immune system and is thereby effective for treating various inflammatory reactions and/or infectious diseases such as colds, sinusitis, urinary infections.
- the recommanded treatment is a dose of 1 00g per day of the fermented dairy product for a period of 10 to 60 days depending on the case.
- the fermented dairy product neutralizes side effects caused by antibiotics.
- the fermented dairy product of the invention has also been found to have significant effect in treating diseases and infections related to the intestinal tract such as diarrhea, diverticulitis, mega-colon, Crohn disease. Indeed, the applicant has found that daily consumption of the dairy product of the invention eliminates most cases of the above-mentioned diseases.
- the fermented dairy product of the present invention contains a fair amount of folic acid and vitamin B1 2 which was produced during fermentation of the lactic culture.
- consumption of such product resulted in fast recuperation time in subjects whom regularly exercise. This observation is especially true for older individuals. As a matter of fact, 8 out of
- the fermented dairy product according to the invention may also be used for the treatment of high blood levels of cholesterol.
- the recommended treatment consists of a dose of 100g per day for a period of 30 to 60 days.
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- Microbiology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Mycology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Dairy Products (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002271930A CA2271930C (en) | 1996-11-29 | 1997-11-28 | Lactic ferment comprising a particular strain of lactobacillus acidophilus and use thereof |
AU51137/98A AU5113798A (en) | 1996-11-29 | 1997-11-28 | Lactic ferment comprising a particular strain of (lactobacillus acidophilus) and use thereof |
DE69737420T DE69737420T2 (en) | 1996-11-29 | 1997-11-28 | MILK ALLOY THE SPECIAL STRAIN OF LACTOBACILLUS ACIDOPHILUS CONTAINS AND USES |
EP97945702A EP0951531B1 (en) | 1996-11-29 | 1997-11-28 | Lactic ferment comprising a particular strain of lactobacillus acidophilus and use thereof |
US09/322,030 US6607905B1 (en) | 1996-11-29 | 1999-05-28 | Lactic ferment comprising a particular strain of lactobacillus acidophilus and use thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3215796P | 1996-11-29 | 1996-11-29 | |
US60/032,157 | 1996-11-29 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/322,030 Continuation US6607905B1 (en) | 1996-11-29 | 1999-05-28 | Lactic ferment comprising a particular strain of lactobacillus acidophilus and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1998023727A1 true WO1998023727A1 (en) | 1998-06-04 |
Family
ID=21863414
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CA1997/000915 WO1998023727A1 (en) | 1996-11-29 | 1997-11-28 | Lactic ferment comprising a particular strain of lactobacillus acidophilus and use thereof |
Country Status (8)
Country | Link |
---|---|
US (1) | US6607905B1 (en) |
EP (2) | EP0951531B1 (en) |
AT (1) | ATE355360T1 (en) |
AU (1) | AU5113798A (en) |
CA (1) | CA2271930C (en) |
DE (1) | DE69737420T2 (en) |
ES (1) | ES2283027T3 (en) |
WO (1) | WO1998023727A1 (en) |
Cited By (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999010476A1 (en) | 1997-08-21 | 1999-03-04 | New Zealand Dairy Board | Immunity enhancing lactic acid bacteria |
WO2000035465A2 (en) * | 1998-12-11 | 2000-06-22 | Urex Biotech Inc. | Oral administration of lactobacillus for the treatment and prevention of urogenital infection |
WO2000067583A2 (en) * | 1999-05-07 | 2000-11-16 | Compagnie Gervais Danone | Use of lactic acid bacteria in the preparation of fermented milks for the treatment of depressed immunity levels |
WO2000071139A2 (en) * | 1999-05-25 | 2000-11-30 | Gregor Reid | Lactobacillus compositions and methods for preventing wound infections and biofilm formation on implantable surgical devices |
WO2000071138A2 (en) * | 1999-05-25 | 2000-11-30 | Gregor Reid | Oral administration of lactobacillus for the maintenance of health in women |
ES2155783A1 (en) * | 1999-05-07 | 2001-05-16 | Danone Sa | Lactic acid bacteria used in the preparation of orally-administrable fermented milks for the treatment of temporarily-depressed immunity levels in individuals subjected to physiological stress |
ES2155782A1 (en) * | 1999-05-07 | 2001-05-16 | Danone Sa | Lactic acid bacteria used in the preparation of orally-administrable fermented milks for the treatment of temporarily-depressed immunity levels in individuals subjected to physiological stress |
WO2001097821A1 (en) * | 2000-06-19 | 2001-12-27 | Mucoprotec Pty Ltd | Immunotherapy or treating bacterial or viral infection at mucosal surfaces with probiotics, and compositions therefor. |
ES2169675A1 (en) * | 2000-07-19 | 2002-07-01 | Danone Sa | Human colon anti inflammation agent includes a specific bacteria material readily released into the colon |
WO2004106498A1 (en) * | 2003-05-30 | 2004-12-09 | Shanghai Bright Dairy & Food Co., Ltd. | Lactobacillus casei bd-ii strain and used to reduce blood cholesterol |
WO2005123100A1 (en) * | 2004-06-18 | 2005-12-29 | Bio-K Plus International Inc. | Lactic bacteria and their use in the prevention of diarrhea |
WO2008077229A1 (en) * | 2006-12-22 | 2008-07-03 | Luquet Francois-Marie | Growth inhibition of microorganisms by lactic acid bacteria |
US7785635B1 (en) | 2003-12-19 | 2010-08-31 | The Procter & Gamble Company | Methods of use of probiotic lactobacilli for companion animals |
WO2011000124A1 (en) * | 2009-07-02 | 2011-01-06 | Universidad De Concepcion | Pharmaceutical composition including viable probiotic strains of lactobacillus spp. used for the prevention and recovery of individuals with urinary tract infections and immunocompromised individuals |
US7887794B2 (en) | 2001-11-27 | 2011-02-15 | Bio-K Plus International, Inc. | Lactic acid bacteria and their use in the treatment of cancer |
US7906112B2 (en) | 2003-12-19 | 2011-03-15 | The Procter & Gamble Company | Canine probiotic Lactobacilli |
US7998473B2 (en) | 2003-12-19 | 2011-08-16 | The Procter & Gamble Company | Methods of treatment or prevention of gastrointestinal disorders using canine probiotic bifidobacterium |
US8034601B2 (en) | 2005-05-31 | 2011-10-11 | The Procter & Gamble Company | Feline probiotic bifidobacteria |
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US8563522B2 (en) | 1997-07-08 | 2013-10-22 | The Iams Company | Method of maintaining and/or attenuating a decline in quality of life |
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- 1997-11-28 DE DE69737420T patent/DE69737420T2/en not_active Expired - Lifetime
- 1997-11-28 AU AU51137/98A patent/AU5113798A/en not_active Abandoned
- 1997-11-28 ES ES97945702T patent/ES2283027T3/en not_active Expired - Lifetime
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Also Published As
Publication number | Publication date |
---|---|
CA2271930A1 (en) | 1998-06-04 |
AU5113798A (en) | 1998-06-22 |
US6607905B1 (en) | 2003-08-19 |
ATE355360T1 (en) | 2006-03-15 |
ES2283027T3 (en) | 2007-10-16 |
CA2271930C (en) | 2006-10-17 |
DE69737420D1 (en) | 2007-04-12 |
EP0951531A1 (en) | 1999-10-27 |
EP2159277A1 (en) | 2010-03-03 |
DE69737420T2 (en) | 2007-11-15 |
EP0951531B1 (en) | 2007-02-28 |
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