WO1998021182A2 - Use of cis-δ4 analogs of prostaglandins as ocular hypotensives - Google Patents
Use of cis-δ4 analogs of prostaglandins as ocular hypotensives Download PDFInfo
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- WO1998021182A2 WO1998021182A2 PCT/US1997/020857 US9720857W WO9821182A2 WO 1998021182 A2 WO1998021182 A2 WO 1998021182A2 US 9720857 W US9720857 W US 9720857W WO 9821182 A2 WO9821182 A2 WO 9821182A2
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- alkyl
- acyl
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- 229940094443 oxytocics prostaglandins Drugs 0.000 title abstract description 18
- 208000001953 Hypotension Diseases 0.000 title 1
- 208000021822 hypotensive Diseases 0.000 title 1
- 230000001077 hypotensive effect Effects 0.000 title 1
- 238000000034 method Methods 0.000 claims abstract description 16
- 206010018307 Glaucoma and ocular hypertension Diseases 0.000 claims abstract description 6
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
Definitions
- the present invention relates to novel compounds for the treatment of glaucoma and ocular hypertension.
- the present invention relates to the use of certain cis-A 4 analogs of D and F series prostaglandins to treat glaucoma and ocular hypertension.
- Glaucoma is a progressive disease which leads to optic nerve damage, and, ultimately, total loss of vision.
- the causes of this disease have been the subject of extensive studies for many years, but are still not fully understood.
- the principal symptom of and/or risk factor for the disease is elevated intraocular pressure or ocular hypertension due to excess aqueous humor in the anterior chamber of the eye.
- IOP elevated intraocular pressure
- beta-blockers and carbonic anhydrase inhibitors can be at least partially controlled by administering drugs which either reduce the production of aqueous humor within the eye, such as beta-blockers and carbonic anhydrase inhibitors, or increase the flow of aqueous humor out of the eye, such as miotics and sympathomimetics.
- Miotics such as pilocarpine can cause blurring of vision and other visual side effects, which may lead either to decreased patient compliance or to termination of therapy.
- Systemically administered carbonic anhydrase inhibitors can also cause serious side effects, such as nausea, dyspepsia, fatigue, and metabolic acidosis, which side effects can affect patient compliance and/or necessitate the termination of treatment.
- Beta- blockers have increasingly become associated with serious pulmonary side effects attributable to their effects on beta-2 receptors in pulmonary tissue. Sympathomimetics may cause tachycardia, arrhythmia and hypertension.
- prostaglandins and prostaglandin derivatives have been described in the art as being useful in reducing intraocular pressure.
- prostaglandin therapy for the treatment of elevated intraocular pressure is attended by undesirable side-effects, such as irritation and hyperemia of varying severity and duration.
- undesirable side-effects such as irritation and hyperemia of varying severity and duration.
- Prostaglandins are metabolite derivatives of arachidonic acid. Arachidonic acid in the body is converted to prostaglandin G 2 , which is subsequently converted to prostaglandin H 2 . Other naturally occurring prostaglandins are derivatives of prostaglandin H 2 .
- a number of different types of prostaglandins have been discovered including A, B, D, E, F,G,I and J-Series prostaglandins (EP 0 561 073 Al). Of interest in the present invention are compounds which are believed to exhibit IOP lowering mechanisms similar to those exhibited by PGD 2 (a D-series prostaglandin of formula I) and PGF 2 ⁇ (an F-series prostaglandin of formula II):
- PGD 2 receptor activation leads to second messenger activation and in particular, to the stimulation of adenylate cyclase and resultant increases in cAMP levels (Thierauch, Prostaglandins and their Receptors: II. Receptor Structure and Signal Transduction, Journal of Hypertension, volume 12, pages 1-5 (1994). Regardless of the mechanism, PGD 2 has been shown to lower IOP (Nakajima, Effects of Prostaglandin D 2 and its analogue, BW245C, on Intraocular Pressure in Humans, Graefe's Archive Ophthalmology, volume 229, pages 411-413 (1991)). Thus, it has been of interest in the ophthalmic field to develop synthetic PGD 2 analogs with IOP lowering efficacy.
- the present invention is directed to compositions and methods of their use in treating IOP and ocular hypertension.
- the present invention provides certain classes of cis-A prostaglandin analogs, and methods of their use in treating glaucoma and ocular hypertension.
- the mechanism of action by which PGD 2 and PGF 2 ⁇ type prostaglandins lower IOP is not well understood.
- the inventors postulate that the compounds of the present invention, with a cis double bond between carbons 4 and 5 in the alpha ( ⁇ ) chain, are less susceptible to metabolic degradation than are their non-cis-A 4 counterparts, and therefore enjoy a longer in vivo half-life than the non- cis-A compounds. A longer in vivo half life should enable relatively lower dosing and a reduction in side effects.
- cis-A analogs of the present invention exhibit an improved therapeutic profile in the treatment of glaucoma and ocular hypertension when compared to natural prostaglandins and many of their known analogs.
- the cis-A 4 analogs of the present invention are heptenoic acid derivatives having the following formula III:
- A CO 2 R, CONR'R 2 , CH 2 OR 3 , or CH 2 NR 4 R 5 ;
- R 3 H, acyl, or alkyl;
- n 0 or 2;
- Y a phenyl ring optionally substituted with alkyl, halo, trihalomethyl, alkoxy, acyl, acyloxy, amino, alkylamino, acylamino, or hydroxy; or
- Z H, alkyl, alkoxy, acyl, acyloxy, halo, trihalomethyl, amino, alkylamino, acylamino, or hydroxy;
- a ii B R O , where R is as defined above;
- Y a phenyl ring, optionally substituted with halo.
- the term "pharmaceutically acceptable ester” means any ester that would be suitable for therapeutic administration to a patient by any conventional means without significant deleterious health consequences; and "ophthalmically acceptable ester” means any pharmaceutically acceptable ester that would be suitable for ophthalmic application, i.e. non-toxic and non- irritating.
- Y phenyl, optionally substituted with halo or trihalomethyl
- n 0;
- X CH 2 CH 2 or CH 2 O;
- Y a phenyl ring, optionally substituted with halo.
- the individual enantiomers can be enantioselectively synthesized from the appropriate enantiomerically pure or enriched starting material by means such as those described below. Alternatively, they may be enantioselectively synthesized from racemic/non-racemic or achiral starting materials.
- racemic and non-racemic mixtures may also be isolated from racemic and non-racemic mixtures by a number of known methods, e.g. by purification of a sample by chiral HPLC (A Practical Guide to Chiral Separations by HPLC, G. Subramanian, Ed., VCH Publishers: New York, 1994; Chiral Separations by HPLC, A.M. Krstulovic, Ed., Ellis Horwood Ltd. Publishers, 1989), or by enantioselective hydrolysis of a carboxylic acid ester sample by an enzyme (Ohno, M.; Otsuka, M. Organic Reactions, volume 37, page 1 (1989)).
- racemic and non-racemic mixtures may be obtained by several means, including without limitation, nonenantioselective synthesis, partial resolution or even mixing samples having different enantiomeric ratios.
- A CO 2 R, CONR'R 2 , CH 2 OR 3 , or CH 2 NR 4 R 5 ;
- R H or cationic salt moiety, or CO 2 R forms a pharmaceutically acceptable ester moiety;
- R 3 H, acyl, or alkyl;
- n 0 or 2;
- a hatched line as used e.g. at carbon 9, indicates the ⁇ configuration.
- a solid triangular line as used e.g. at carbon 12, indicates the ⁇ configuration.
- Dashed lines on bonds, e.g. between carbons 13 and 14, indicate a single or double bond. Two solid lines between carbons indicate a double bond of the specified configuration.
- Wittig reaction of 3 with Ph 3 P + CH 2 OCH 3 Cl " in THF at 0 °C in the presence of potassium t- butoxide (KOBu') provides enol ether 4, which is hydrolyzed with TsOH in THF/water to yield lactol 5.
- Wittig reaction of 5 with Ph 3 P + (CH 2 ) 3 CO 2 H Br " in THF at 0 °C in the presence of KOBu followed by alkylation of the product carboxylic acid with isopropyl iodide in acetone in the presence of DBU, yields IV after purification via silica gel chromatography.
- Swern oxidation of 28 (oxalyl chloride, DMSO, CH 2 C1 2 , ⁇ Et 3 , -78 °C) affords aldehyde 29, which is treated with (MeO) 2 P(O)CH 2 C(O)CH 2 OC 6 H 4 - -CF 3 , NEt 3 , and LiCl in THF to provide enone 30.
- Luche reduction of 30 NaBH 4 , CeCl 3 , MeOH, 0 °C gives allyl alcohol 31 as a mixture of C-15 diastereomers. Acidic deprotection of 31 using aqueous HC1 in isopropanol, followed by purification via silica gel chromatography, gives VII.
- the silyl ether 36 thus obtained was dissolved in 20 mL of THF and the solution was treated with tetra-n-butylammonium fluoride (7.0 mL, 1.0 M in THF, 7.0 mmol) at room temperature for 2 h. The reaction mixture was then poured into water and was extracted with EtOAc (3X25 mL). The organic extracts were combined and dried (MgSO4), filtered and concentrated.
- tetra-n-butylammonium fluoride 7.0 mL, 1.0 M in THF, 7.0 mmol
- the reaction was gradually warmed to room temperature and then poured into 50 mL of water. The layers were separated and the water layer was extracted with 3X25 mL of CH 2 C1 2 . The combined organic extracts were washed with water and brine, and dried (MgSO 4 ).
- the allyl alcohol 40 (0.30 g, 0.55 mmol) was dissolved in a mixture of 10 mL of methanol and 1.0 mL of water, and the solution was cooled to 0 °C. Approximately 10 drops of 12 NHC1 was added to it dropwise, and stirring was continued at 0 °C for 15 min and then at room temperature for 1 h. The reaction was then quenched by the addition of solid ⁇ aHC0 3 , and the suspension was partitioned between CHC1 3 and water. The layers were separated and the aqueous layer was extracted with 3X25 mL of CHC1 3 . The organic extracts were combined and washed with water (2X10 mL) and brine and dried (Na 2 SO 4 ).
- Ketone reduction of 11 with (+)-5-chlorodiisopinocampheylborane in THF at 0 °C affords C-15 ⁇ -hydroxy isomer 41 after chromatographic purification.
- Olefm reduction using Pd/C under a hydrogen atmosphere in ethyl acetate solvent provides alcohol 42, which is fluorinated using DAST to yield ⁇ -fluoride 43.
- Debenzoylation with potassium carbonate in methanol gives alcohol 44, which is treated with 3,4-dihydro-27J-pyran in methylene chloride in the presence of TsOH to afford THP ether 45.
- the cis-A 4 analogs of the present invention may be formulated in various pharmaceutical compositions for administering to humans and other mammals as a treatment of glaucoma or ocular hypertension.
- pharmaceutically effective amount refers to that amount of a compound of the present invention which lowers IOP when administered to a patient, especially a mammal.
- the preferred route of administration is topical.
- the compounds of the present invention can be administered as solutions, suspensions, or emulsions (dispersions) in an ophthalmically acceptable vehicle.
- ophthalmically acceptable vehicle refers to any substance or combination of substances which are non-reactive with the compounds and suitable for administration to a patient. Solubilizers and stabilizers are deemed to be non-reactive.
- Preferred are aqueous vehicles suitable for topical application to the patient's eyes.
- the compounds of the present invention are generally formulated as between about 0.00003 to about 0.5 percent by weight (wt%) solutions in water at a pH between 4.5 to 8.0.
- the compounds are preferably formulated as between about 0.0005 to about 0.03 wt% and, most preferably, between about 0.001 and about 0.01 wt%. While the precise regimen is left to the discretion of the clinician, it is recommended that the resulting solution be topically applied by placing one drop in each eye one or two times a day.
- ingredients which may be desirable to use in the ophthalmic preparations of the present invention include preservatives, co-solvents and viscosity building agents.
- Ophthalmic products are typically packaged in multidose form. Preservatives are
- Prostaglandins and particularly ester derivatives, typically have limited solubility
- compositions include: Polysorbate 20, 60 and 80; Pluronic F-68, F-84
- CREMOPHORE ® EL polyoxyl 35 castor oil
- Viscosity Agents between about 0.01% and about 2% by weight.
- Viscosity greater than that of simple aqueous solutions may be desirable to increase ocular absorption of the active compound, to decrease variability in dispensing the formulations, to decrease physical separation of components of a suspension or emulsion of formulation and/or otherwise to improve the ophthalmic formulation.
- Such viscosity building agents include, for example, polyvinyl alcohol, polyvinyl pyrrolidone, methyl cellulose, hydroxy propyl methylcellulose, hydroxyethyl cellulose, carboxymethyl cellulose, hydroxy propyl cellulose, chondroitin sulfate and salts thereof, hyaluronic acid and salts thereof, and other agents known to those skilled in the art. Such agents are typically employed at a level between about 0.01% and about 2% by weight
- Preferred formulations of cis-A prostaglandins of the present invention include the following Examples 8-11:
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Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP52285998A JP2001504122A (en) | 1996-11-12 | 1997-11-07 | CIS-Δ ▲ 44 analogs of prostaglandins as intraocular pressure lowering agents |
US09/284,431 US6235779B1 (en) | 1996-11-12 | 1997-11-07 | Use of cis-Δ4 analogs of prostaglandins as ocular hypotensives |
CA002269853A CA2269853A1 (en) | 1996-11-12 | 1997-11-07 | Use of cis-.delta.4 analogs of prostaglandins as ocular hypotensives |
EP97948304A EP0944593A2 (en) | 1996-11-12 | 1997-11-07 | $i(CIS)-$g(D)?4 ANALOGS OF PROSTAGLANDINS AS OCULAR HYPOTENSIVES |
AU54393/98A AU5439398A (en) | 1996-11-12 | 1997-11-07 | Cis-delta4 analogs of prostaglandins as ocular hypotensives |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3050496P | 1996-11-12 | 1996-11-12 | |
US60/030,504 | 1996-11-12 |
Publications (2)
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WO1998021182A2 true WO1998021182A2 (en) | 1998-05-22 |
WO1998021182A3 WO1998021182A3 (en) | 1998-06-25 |
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Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/020857 WO1998021182A2 (en) | 1996-11-12 | 1997-11-07 | Use of cis-δ4 analogs of prostaglandins as ocular hypotensives |
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US (1) | US6235779B1 (en) |
EP (1) | EP0944593A2 (en) |
JP (1) | JP2001504122A (en) |
KR (1) | KR20000053228A (en) |
CN (1) | CN1237157A (en) |
AU (1) | AU5439398A (en) |
CA (1) | CA2269853A1 (en) |
WO (1) | WO1998021182A2 (en) |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998020880A2 (en) * | 1996-11-12 | 1998-05-22 | Alcon Laboratories, Inc. | 11-halo prostaglandins for the treatment of glaucoma or ocular hypertension |
WO2001087897A1 (en) * | 2000-05-19 | 2001-11-22 | Chirotech Technology Limited | Process for the preparation of 11-oxaprostaglandins and intermediates therein |
WO2010096123A2 (en) | 2008-10-29 | 2010-08-26 | Aerie Pharmaceuticals, Inc. | Amino acid salts of prostaglandins |
WO2014144781A1 (en) | 2013-03-15 | 2014-09-18 | Aerie Pharmaceuticals, Inc. | Combination therapy |
US9643927B1 (en) | 2015-11-17 | 2017-05-09 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
US9675539B2 (en) | 2000-03-31 | 2017-06-13 | Duke University | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
US10112920B2 (en) | 2008-07-25 | 2018-10-30 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
US10174017B2 (en) | 2009-05-01 | 2019-01-08 | Aerie Pharmaceuticals, Inc. | Dual mechanism inhibitors for the treatment of disease |
US10472327B2 (en) | 2007-01-10 | 2019-11-12 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
US10858339B2 (en) | 2017-03-31 | 2020-12-08 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
US11389441B2 (en) | 2016-08-31 | 2022-07-19 | Aerie Pharmaceuticals, Inc. | Ophthalmic compositions |
US11427563B2 (en) | 2018-09-14 | 2022-08-30 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000051980A1 (en) | 1999-03-05 | 2000-09-08 | The Procter & Gamble Company | C16 unsaturated fp-selective prostaglandins analogs |
US20020172693A1 (en) | 2000-03-31 | 2002-11-21 | Delong Michell Anthony | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
CN105566192B (en) * | 2006-10-02 | 2019-01-22 | 于崇曦 | Positively charged water-soluble prodrugs of prostaglandins and related compounds with fast skin penetration rate |
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WO1990002553A1 (en) * | 1988-09-06 | 1990-03-22 | Pharmacia Ab | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
EP0299914B1 (en) * | 1987-07-17 | 1993-04-07 | Schering Aktiengesellschaft | 9-halogen (z) prostaglandin derivatives, process for their production and their use as medicines |
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ZA771725B (en) | 1976-04-21 | 1978-02-22 | Upjohn Co | Ayal prostaglandin analogs |
US4212985A (en) | 1978-04-28 | 1980-07-15 | The Upjohn Company | cis-4,5-Didehydro-16-phenoxy-PGE1 compounds |
US4599353A (en) | 1982-05-03 | 1986-07-08 | The Trustees Of Columbia University In The City Of New York | Use of eicosanoids and their derivatives for treatment of ocular hypertension and glaucoma |
ATE108330T1 (en) | 1987-09-18 | 1994-07-15 | R Tech Ueno Ltd | HYPOTENSIVE OCULAR MEDIUM. |
US5321128A (en) | 1988-09-06 | 1994-06-14 | Kabi Pharmacia Ab | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
DK0561073T3 (en) | 1992-03-19 | 2001-11-12 | R Tech Ueno Ltd | Treatment of eye hypertension |
-
1997
- 1997-11-07 JP JP52285998A patent/JP2001504122A/en active Pending
- 1997-11-07 EP EP97948304A patent/EP0944593A2/en not_active Withdrawn
- 1997-11-07 WO PCT/US1997/020857 patent/WO1998021182A2/en not_active Application Discontinuation
- 1997-11-07 KR KR1019990704203A patent/KR20000053228A/en not_active Application Discontinuation
- 1997-11-07 AU AU54393/98A patent/AU5439398A/en not_active Abandoned
- 1997-11-07 CN CN97199645A patent/CN1237157A/en active Pending
- 1997-11-07 CA CA002269853A patent/CA2269853A1/en not_active Abandoned
- 1997-11-07 US US09/284,431 patent/US6235779B1/en not_active Expired - Fee Related
Patent Citations (2)
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EP0299914B1 (en) * | 1987-07-17 | 1993-04-07 | Schering Aktiengesellschaft | 9-halogen (z) prostaglandin derivatives, process for their production and their use as medicines |
WO1990002553A1 (en) * | 1988-09-06 | 1990-03-22 | Pharmacia Ab | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
Cited By (37)
Publication number | Priority date | Publication date | Assignee | Title |
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WO1998020880A3 (en) * | 1996-11-12 | 1998-08-20 | Alcon Lab Inc | 11-Halo prostaglandins for the treatment of glaucoma or ocular hypertension |
WO1998020880A2 (en) * | 1996-11-12 | 1998-05-22 | Alcon Laboratories, Inc. | 11-halo prostaglandins for the treatment of glaucoma or ocular hypertension |
US9675539B2 (en) | 2000-03-31 | 2017-06-13 | Duke University | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
WO2001087897A1 (en) * | 2000-05-19 | 2001-11-22 | Chirotech Technology Limited | Process for the preparation of 11-oxaprostaglandins and intermediates therein |
US10472327B2 (en) | 2007-01-10 | 2019-11-12 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
US10899714B2 (en) | 2007-01-10 | 2021-01-26 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
US10882840B2 (en) | 2008-07-25 | 2021-01-05 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
US11021456B2 (en) | 2008-07-25 | 2021-06-01 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
US10112920B2 (en) | 2008-07-25 | 2018-10-30 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
US10532993B2 (en) | 2008-07-25 | 2020-01-14 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
WO2010096123A2 (en) | 2008-10-29 | 2010-08-26 | Aerie Pharmaceuticals, Inc. | Amino acid salts of prostaglandins |
US11028081B2 (en) | 2009-05-01 | 2021-06-08 | Aerie Pharmaceuticals, Inc. | Dual mechanism inhibitors for the treatment of disease |
US11618748B2 (en) | 2009-05-01 | 2023-04-04 | Aerie Pharmaceuticals, Inc. | Dual mechanism inhibitors for the treatment of disease |
US10174017B2 (en) | 2009-05-01 | 2019-01-08 | Aerie Pharmaceuticals, Inc. | Dual mechanism inhibitors for the treatment of disease |
US10654844B2 (en) | 2009-05-01 | 2020-05-19 | Aerie Pharmaceuticals, Inc. | Dual mechanism inhibitors for the treatment of disease |
US10316029B2 (en) | 2009-05-01 | 2019-06-11 | Aerie Pharmaceuticals, Inc. | Dual mechanism inhibitors for the treatment of disease |
US9993470B2 (en) | 2013-03-15 | 2018-06-12 | Aerie Pharmaceuticals, Inc. | Combination therapy |
US11197853B2 (en) | 2013-03-15 | 2021-12-14 | Aerie Pharmaceuticals, Inc. | Combination therapy |
US10568878B2 (en) | 2013-03-15 | 2020-02-25 | Aerie Pharmaceuticals, Inc. | Combination therapy |
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US9931336B2 (en) | 2013-03-15 | 2018-04-03 | Aerie Pharmaceuticals, Inc. | Combination therapy |
EP3811943A1 (en) | 2013-03-15 | 2021-04-28 | Aerie Pharmaceuticals, Inc. | Compound for use in the treatment of ocular disorders |
US11020385B2 (en) | 2013-03-15 | 2021-06-01 | Aerie Pharmaceuticals, Inc. | Combination therapy |
US9849122B2 (en) | 2013-03-15 | 2017-12-26 | Aerie Pharmaceuticals, Inc. | Combination therapy |
EP4218759A2 (en) | 2013-03-15 | 2023-08-02 | Aerie Pharmaceuticals, Inc. | Combination therapy |
US11185538B2 (en) | 2013-03-15 | 2021-11-30 | Aerie Pharmaceuticals, Inc. | Compositions for treating glaucoma or reducing intraocular pressure |
US10588901B2 (en) | 2013-03-15 | 2020-03-17 | Aerie Pharmaceuticals, Inc. | Combination therapy |
WO2014144781A1 (en) | 2013-03-15 | 2014-09-18 | Aerie Pharmaceuticals, Inc. | Combination therapy |
US9643927B1 (en) | 2015-11-17 | 2017-05-09 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
US11389441B2 (en) | 2016-08-31 | 2022-07-19 | Aerie Pharmaceuticals, Inc. | Ophthalmic compositions |
US11707460B2 (en) | 2016-08-31 | 2023-07-25 | Aerie Pharmaceuticals, Inc. | Ophthalmic compositions |
US11312700B2 (en) | 2017-03-31 | 2022-04-26 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
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Also Published As
Publication number | Publication date |
---|---|
CA2269853A1 (en) | 1998-05-22 |
AU5439398A (en) | 1998-06-03 |
EP0944593A2 (en) | 1999-09-29 |
CN1237157A (en) | 1999-12-01 |
KR20000053228A (en) | 2000-08-25 |
WO1998021182A3 (en) | 1998-06-25 |
JP2001504122A (en) | 2001-03-27 |
US6235779B1 (en) | 2001-05-22 |
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