WO1986007357A2 - Cyclopentapyrazole and tetrahydroindazole compounds - Google Patents

Cyclopentapyrazole and tetrahydroindazole compounds Download PDF

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Publication number
WO1986007357A2
WO1986007357A2 PCT/US1986/001233 US8601233W WO8607357A2 WO 1986007357 A2 WO1986007357 A2 WO 1986007357A2 US 8601233 W US8601233 W US 8601233W WO 8607357 A2 WO8607357 A2 WO 8607357A2
Authority
WO
WIPO (PCT)
Prior art keywords
cyclopentapyrazole
tetrahydroindazole
compounds
novel
agents
Prior art date
Application number
PCT/US1986/001233
Other languages
French (fr)
Other versions
WO1986007357A3 (en
Inventor
Herman W Smith
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of WO1986007357A2 publication Critical patent/WO1986007357A2/en
Publication of WO1986007357A3 publication Critical patent/WO1986007357A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel compositions of matter and their therapeutic applications. More particularly, the present invention consists of novel cyclopentapyrazole and tetrahydroindazole compounds of formula (XXX) and their use as antiallergy agents, antiinflammatory agents or intermediates.
PCT/US1986/001233 1985-06-14 1986-06-03 Cyclopentapyrazole and tetrahydroindazole compounds WO1986007357A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74534385A 1985-06-14 1985-06-14
US745,343 1985-06-14

Publications (2)

Publication Number Publication Date
WO1986007357A2 true WO1986007357A2 (en) 1986-12-18
WO1986007357A3 WO1986007357A3 (en) 1987-04-23

Family

ID=24996305

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1986/001233 WO1986007357A2 (en) 1985-06-14 1986-06-03 Cyclopentapyrazole and tetrahydroindazole compounds

Country Status (3)

Country Link
US (1) US4851425A (en)
EP (1) EP0226624A1 (en)
WO (1) WO1986007357A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0529854A2 (en) * 1991-08-08 1993-03-03 Ortho Pharmaceutical Corporation Tetrahydroindazole, tetrahydrocyclopentapyrazole, and hexahydrocycloheptapyrazole compounds and their use as HMG-COA reductase inhibitors
US5817669A (en) * 1994-06-14 1998-10-06 Dainippon Pharmaceutical Co., Ltd. Compounds, processes for the preparation thereof and anti-tumor agents

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0509207A (en) * 2004-03-24 2007-08-28 Janssen Pharmaceutica Nv cannabinoid tetrahydro-indazole modulators
RU2459808C1 (en) * 2011-02-25 2012-08-27 Государственное образовательное учреждение высшего профессионального образования "Пермский государственный университет" 3-(1-naphthylmethyl)-4,5,6,7-tetrahydroindazole hydrochloride exhibiting antimicrobial properties

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50157363A (en) * 1974-06-06 1975-12-19
SU553246A1 (en) * 1975-10-07 1977-04-05 Московский Ордена Ленина И Ордена Трудового Красного Знамени Химикотехнологический Институт Им.Д.И.Менделеева The method of obtaining indazol-3-aldehyde

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1948793A1 (en) * 1969-09-26 1971-04-01 Rhein Chemie Rheinau Gmbh Process for the preparation of 4,5,6,7-tetrahydroindazoles
FR2315924A1 (en) * 1975-07-03 1977-01-28 Enzypha Analgesic and antiinflammatory polymethylene pyrazole derivs. - prepd. by cyclizing 2-acyl cyclic ketones with hydrazine derivs.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50157363A (en) * 1974-06-06 1975-12-19
SU553246A1 (en) * 1975-10-07 1977-04-05 Московский Ордена Ленина И Ордена Трудового Красного Знамени Химикотехнологический Институт Им.Д.И.Менделеева The method of obtaining indazol-3-aldehyde

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, Volume 85, No. 17, 25 October 1976, (Columbus, Ohio, US), s ee page 644, Abstract 123913n, & JP, A, 75157363 (Sumitomo Chemical Co., Ltd) 19 decembre 1975 *
CHEMICAL ABSTRACTS, Volume 87, No. 23, 5 December 1977, (Columbus, Ohio, US), see page 613, Abstract 184511t, & SU, A, 553 246 (Mendeleev, D.I., Chemical-Technological Institute, Moscow) 5 avril 1977 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0529854A2 (en) * 1991-08-08 1993-03-03 Ortho Pharmaceutical Corporation Tetrahydroindazole, tetrahydrocyclopentapyrazole, and hexahydrocycloheptapyrazole compounds and their use as HMG-COA reductase inhibitors
EP0529854A3 (en) * 1991-08-08 1993-03-31 Ortho Pharmaceutical Corporation Tetrahydroindazole, tetrahydrocyclopentapyrazole, and hexahydrocycloheptapyrazole compounds and their use as hmg-coa reductase inhibitors
AU656602B2 (en) * 1991-08-08 1995-02-09 Ortho Pharmaceutical Corporation HMG-COA reductase inhibitors
US5817669A (en) * 1994-06-14 1998-10-06 Dainippon Pharmaceutical Co., Ltd. Compounds, processes for the preparation thereof and anti-tumor agents

Also Published As

Publication number Publication date
EP0226624A1 (en) 1987-07-01
US4851425A (en) 1989-07-25
WO1986007357A3 (en) 1987-04-23

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