US2470297A - Inhalator - Google Patents
Inhalator Download PDFInfo
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- US2470297A US2470297A US772104A US77210447A US2470297A US 2470297 A US2470297 A US 2470297A US 772104 A US772104 A US 772104A US 77210447 A US77210447 A US 77210447A US 2470297 A US2470297 A US 2470297A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0005—Details of inhalators; Constructional features thereof with means for agitating the medicament
- A61M15/0006—Details of inhalators; Constructional features thereof with means for agitating the medicament using rotating means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0013—Details of inhalators; Constructional features thereof with inhalation check valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0018—Details of inhalators; Constructional features thereof with exhalation check valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0091—Inhalators mechanically breath-triggered
- A61M15/0098—Activated by exhalation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/04—Tracheal tubes
- A61M16/0488—Mouthpieces; Means for guiding, securing or introducing the tubes
- A61M16/049—Mouthpieces
- A61M16/0493—Mouthpieces with means for protecting the tube from damage caused by the patient's teeth, e.g. bite block
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/06—Respiratory or anaesthetic masks
- A61M16/0666—Nasal cannulas or tubing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0618—Nose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0625—Mouth
Definitions
- My invention relates to therapeutic medication and includes among its objects and advantages increased convenience in medication with dry medicaments in powder form, especially with respect to accuracy of dosage and accurate placement of the material.
- vasoconstrictors In addition to Water-soluble anti-biotics, solid inhalation therapy is of value in connection with certain vasoconstrictors, and is indicated for at least some of the known anti-histamine drugs.
- vaso-constrictors are: epinephrine hydrochloride, isopropyl epinephrln and 2-aminoheptane.
- anti-histamine agents are: N-(alpha-pyridyD- N (alpha-thenyl) N', N dimethylethylenediamine hydrochloride, and N-(alpha-pyridyl) -N- (benzyl) -N',N-dimethylethylenediamine hydrochloride.
- I succeed in obtaining such constancy by providing apparatus which is to be utilized by the patient by breathing in and out in a simple, substantially normal way.
- I utilize the energy of the -patients breathing to deliver into each charge of air inhaled a small substantially constant charge of powdered medicament, which charge is delivered quickly, shortly after inhalation begins, and nds its way to the depth of the cavity long before inhalation is finished.
- the apparatus itself and the nose and bronchial tubesl are thoroughly swept and scavenged with pure air during a major portion of the breathing-in-process.
- administration in this way not only contributes to deep penetration of the medicament, but that it becomes unnecessary to pulverize or micronizev the medicament into a true smoke.
- the use of larger particles tends to increase the reliability with which a uniform fraction of the material will passl on through the nose and bronchial tubes without getting caught on the moist Walls.
- Figure l is a side elevation of an inhalator according to the invention:
- Figure 2 is a plan view of the same inhalator :from above;
- Figure 3 is a plan view of the same inhalator from below;
- Figure 4 is a section as on line 4-4 of Figure 2;
- Figure 5 is a longitudinal section of the capsule before it is assembled with the inhalator.
- Figure 6 is a perspective ⁇ of the device in use.
- the main housing IIJ is of transparent plastic,A molded in two halves cemented together on the plane of the section of Figure 4.
- the body deilnes achamberJZ having an outlet opening I4 for the discharge of air into the mouth of the patient.
- Flanges I6 assist the patient in holding the device in place with the teeth as partially indicated in dotted lines in Figure 1.
- the top opening I8 closed by a. plug 20 when it happens that medication through the mouth only is desired. Normally, it will receive a lower end of a bifurcated nose connector piece 22. This is of flexible material with its lower end ,fitted into the opening I8 and the two tips 24 entered inthe nostrils of the patient.
- the bottom portion may advantageously have a wall thickness of about 68 thousandths of an inch, which will secure a satisfactory grip in the opening, and the wall may taper to about 30 thousandths of an inch at the end of the tip so that the tips 24 will be soft and comfortable to the users nostrils.
- Means are provided for discharging a predetermined amount of powdered medicament small enough in quantity to be carried into the air-filled cavity receiving it during a first and preferably minor fraction of each breathing in, or inhalation.
- the chamber I2 has another inlet 40 in its bottom controlled by the simple flap check valve 42. It will be apparent that at the beginning of each inhalation the ap 42 closes immediately and the suction exerted by the patient then throws the ball 34 quickly from the bottom of the tube 32 up into ycontact with the capsule 28.
- simple steel ball functions very well in this connection, but with a ball of aluminum the parts may be designed to secure a slightly better mechanical action,
- the inner end of the tube 32 is provided with four slots 44 extending down the tube far enough so that the ball uncovers and opens them when it moves to the upper end of its path. Thus, ⁇ the user does not experience any material restriction on his breathing.
- a rubber cap 46 which, in undistorted condition, has its bottom dished upward as indicated at 48 in Figure so that pushing thecap home on the lower end of the capsule will stress the bottom 48 and cause it to remain gently pressed upward against the screen 30 until the cap is removed preparatory to using the capsule.
- the upper portion of the capsule is shaped for convenient handling by the user.
- a plastic capsule which may be formed initially with a middle diaphragm 50 at the top of the capsule proper 26, and substantially arcuate closed wall sections rising above the diaphragm 50 and of slightly larger diameter than that of the capsule proper 26 to dene an abutment shoulder 52 to engage the grommet 26.
- various powdered medicaments can be administered at various rates.
- sodium penicillin I prefer to use a screen of about 60 mesh and it is not hard to granulate the powder by trial and error to a grain size such that an administration of 100,000 units is easily accomplishedby normal breathing, in from three to six minutes.
- smoother and more accurate mechanical action can be secured by mixing the penicillin with at least a little other material intended to function as a diluent or vehicle.
- 100,000 units of graular penicillin represents about 90 milligrams of material and the addition to the charge of about 25 milligrams of sulfanilamide makes up into a combined powder that secures materially better and more accurate mechanical functioning.
- a patient inhaling such a charge will receive a full normal dose of penicillin but only about 10% of a normal dose of sulfanilamide.
- the charge may include various combinations of medicaments with or without completely inert vehicles.
- Equipment for introducing an air-borne powdered medicament into body cavities which comprises: a rigid transparent plastic body dening a chamber; said chamber being formed with one end outlet shaped to be gripped between the teeth of the user; said chamber having a lateral outlet positioned below the users nostrils when said first outlet is gripped by the users teeth; a flexible branched conduit having a single lower opening fitting said second chamber outlet, and double upper openings of va size to t into the nostrils of the user; said upper openings being deflnedby flexible material; a tubular inlet at the end of the chamber opposite said first outlet; a ball of diameter sufficient to substantially close said tubular inlet; said tubular inlet being inclined so that the ball normally resides at the intake end of said inlet; an obstruction at the intake end of said inlet end to prevent egress of said ball; an obstruction at the discharge end of said tubular inlet to prevent discharge of said ball into said chamber; said tubular inlet having lateral vent opening adjacent its discharge end positioned to be uncovered by said ball
- -socket means in the wall oi said chamber for receiving and holding said container in a position to. be struck by said ball at-the end of its inward movement; said container having a foraminated bottom; and a charge of powdered medicament in said container of grain size small enough to deliver an increment of medicament through said foraminated bottom each time said ball strikes said container at the beginning of inhalation; a return flow discharge opening in said chamber, and a quick-acting check valve permitting gas to issue from said chamber during exhalation but closing at the beginning of inhalation to compel the air inhaled to enter through said tubular inlet.
- Equipment for introducing an air-borne medicament into body cavities which'comprises: a rigid transparent plastic body dening a chamlber; said chamber being formed with one end outlet shaped to deliver uid to the mouth of the user: said chamber having a lateral outlet positioned below the users nostrils when said rst outlet is gripped by the users teeth; a conduit means for delivering gas from said second chamber outlet into the nostrils of the user; a tubular inlet at the end of the chamber opposite said first outlet: a ball of diameter sufilcient to substantially close said tubular inlet; said tubular inlet being inclined so that the ball normally resides at the intake end of said inlet; an obstruction at the intake end of said inlet end to prevent egress of said ball; an obstruction at the discharge end of said tubular inlet to prevent discharge of said ball into said chamber; said tubular inlet having lateral vent openings adjacent its discharge end positioned to be uncovered by said ball; a removable container for medicament; socket means in the wall of said chamber for receiving said container
- said container having a foraminated bottom; and a charge of powdered -medicament in said container of grain size small enough to deliver an increment of medicament through said ioraminated bottom each time said ball strikes said container at the beginning of inhalation; a. return flow discharge opening in said chamber: and a quick-acting check valve permitting gas to issue from said chamber during exhalation but closing at the beginning of inhalation to compel .the air inhaled to enter through said tubular inlet.
- Equipment for introducing' an airborne powdered medicament into body cavities which comprises: a body dening 'a chamber; said chamber being formed with an outlet shaped to deliver iluid -to the person o! the user; an inlet to said chamber; a medicament container in said chamber having a foraminated Wall; means actuated by the initial flow of inhaled gas through said inlet, for jolting said container to release an increment of medicament through said i'oraminated wall; said chamber being provided with an additional outlet for the exit of gas during exhalation; and an automatic check valve in said additional outlet to prevent inward flow.
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Abstract
654,872. Respiratory appliances. ABBOTT LABORATORIES. Aug. 20, 1948, No. 13228/50. Convention dates, Sept. 4, 1947 and April 30, 1948. Divided out of 654,860. [Class 81 (ii)] A container for dispensing finely divided material has a foraminated end and an external flange with radially extending lugs, remote from the foraminated end, for supporting it in a holder with the foraminated end in the path of a stream of air flowing through the said holder. The invention is described in relation to a medical device for the inhalation of powder of the type described in Specification 654,860 in which a ball 42 is raised by the suction of the patient when he inhales through a mouthpiece 48. At the top of its movement the ball 42 strikes against a cylindrical container 12 which is loosely supported in the body by its flanged end 30, so that medicated powder 14 is sprinkled through a gauze screen 16 into the air stream. The container is provided with a handle 20 and its rim has diametrically placed projections forming a bayonet catch which prevents it inadvertently falling from the body.
Description
MIY 17, 1949 M. R. FIELDS 2,470,297
INHALATOR Filed sept. 4, 1947 IN VEN TOR.
@ci Qaida Patented May 17, 1949 INHALATOR Mack R. Fields, Libertyville, lll., assigner to Abbott Laboratories, North Chicago, lll., a corporation of Illinois Application September 4, 1947, Serial No. 772,104
(Cl. 12S-266) 3 Claims. 1
My invention relates to therapeutic medication and includes among its objects and advantages increased convenience in medication with dry medicaments in powder form, especially with respect to accuracy of dosage and accurate placement of the material.
Many useful medicaments, and especially penicillin and related antibiotics, are subject to substantial or, in some instances, complete alteration by the stomach juices when administered orally. Different patients vary widely in the condition of the alimentary canal and the extent to which oral dosages will be impaired in effectiveness. In fact, the same patient will react differently to the same dosage at dilerent times, because the condition of the patients alimentary canal varies from time to time.
0n this account, precision in treatment has the general treatment thus resulting with high local concentration of the same medicament in whatever body cavity is utilized, including the lungs, and the throat, Y
In addition to Water-soluble anti-biotics, solid inhalation therapy is of value in connection with certain vasoconstrictors, and is indicated for at least some of the known anti-histamine drugs. Illustrative examples of vaso-constrictors are: epinephrine hydrochloride, isopropyl epinephrln and 2-aminoheptane.. Illustrative examples of anti-histamine agents are: N-(alpha-pyridyD- N (alpha-thenyl) N', N dimethylethylenediamine hydrochloride, and N-(alpha-pyridyl) -N- (benzyl) -N',N-dimethylethylenediamine hydrochloride.
Data available so far do not support any reliable generalizations. More particularly, the mere fact that a drug is ineffective or toxic when administered orally aiords no indication that it is suitable for solid inhalation therapy. Many such therapeutic agents which are water soluble, will be found effective by solid inhalation, but both the effect and the degree of effectiveness need to be establishd by spcic test in connection with each substance.
However, especially when the local application is in the lungs, a wide variability in the proportion of powdered material that comes to rest in the nose and in the bronchial tubes and in o0 2 the actual lung itself can only be avoided by a substantial constancy in the method of inhalation.
According to the invention, I succeed in obtaining such constancy by providing apparatus which is to be utilized by the patient by breathing in and out in a simple, substantially normal way. I utilize the energy of the -patients breathing to deliver into each charge of air inhaled a small substantially constant charge of powdered medicament, which charge is delivered quickly, shortly after inhalation begins, and nds its way to the depth of the cavity long before inhalation is finished. Thus the apparatus itself and the nose and bronchial tubesl are thoroughly swept and scavenged with pure air during a major portion of the breathing-in-process. I have found that administration in this way not only contributes to deep penetration of the medicament, but that it becomes unnecessary to pulverize or micronizev the medicament into a true smoke. The use of larger particles tends to increase the reliability with which a uniform fraction of the material will passl on through the nose and bronchial tubes without getting caught on the moist Walls.
Whereas other methods of administration by inhalation known to me are objectionable because the apparatus is expensive or complicated, or because the amount of medicament rendered effective for therapeutic purposes varies uncontrollably over a range of several hundred per cent, or both, it is possible according to the invention to work out dependable procedures which do not require hospitalization or the repeated checking of blood samples.
In the accompanying drawing:
Figure l is a side elevation of an inhalator according to the invention:
Figure 2 is a plan view of the same inhalator :from above;
Figure 3 is a plan view of the same inhalator from below;
Figure 4 is a section as on line 4-4 of Figure 2;
Figure 5 is a longitudinal section of the capsule before it is assembled with the inhalator; and
Figure 6 is a perspective` of the device in use.
In the embodiment of apparatus selected for illustration, the main housing IIJ is of transparent plastic,A molded in two halves cemented together on the plane of the section of Figure 4. The body deilnes achamberJZ having an outlet opening I4 for the discharge of air into the mouth of the patient. Flanges I6 assist the patient in holding the device in place with the teeth as partially indicated in dotted lines in Figure 1. The top opening I8 closed by a. plug 20 when it happens that medication through the mouth only is desired. Normally, it will receive a lower end of a bifurcated nose connector piece 22. This is of flexible material with its lower end ,fitted into the opening I8 and the two tips 24 entered inthe nostrils of the patient. With a suitable grade of rubber the bottom portion may advantageously have a wall thickness of about 68 thousandths of an inch, which will secure a satisfactory grip in the opening, and the wall may taper to about 30 thousandths of an inch at the end of the tip so that the tips 24 will be soft and comfortable to the users nostrils.
Means are provided for discharging a predetermined amount of powdered medicament small enough in quantity to be carried into the air-filled cavity receiving it during a first and preferably minor fraction of each breathing in, or inhalation. By making the energy requirement for the discharge of the medicament extremely low, it is possible to make this discharge, and the timing of the discharge, completely automatic, and to energize it by the energy supplied by the patient in inhaling without imposing enough burden on the muscular strength of the patient to cause any material labor or annoyance, I have illustrated a capsule 26 inserted into place in a rubber grommet 28 set in the upper wall of the body l0. The capsule, when in use, has anopen lower end obstructed by a iine screen 30. Suitable results have been obtained with screens from about 40 to 80 mesh. To jar, or agltate, the 4capsule with the right force at the right time, I provide an inlet tube 32 in which lies a ball 34 freely movable from one end of the tube to the other but restrained from falling out by a lug 36 and from falling into the chamber by a lug 38. Upon reference to Figure 4, it will be observed that the parts are so proportioned that the ball 24 may strike the capsule 28 at the end of its inward movement and thus deliver a blow to discharge powder through the screen 30.
The chamber I2 has another inlet 40 in its bottom controlled by the simple flap check valve 42. It will be apparent that at the beginning of each inhalation the ap 42 closes immediately and the suction exerted by the patient then throws the ball 34 quickly from the bottom of the tube 32 up into ycontact with the capsule 28. simple steel ballfunctions very well in this connection, but with a ball of aluminum the parts may be designed to secure a slightly better mechanical action,
The inner end of the tube 32 is provided with four slots 44 extending down the tube far enough so that the ball uncovers and opens them when it moves to the upper end of its path. Thus,` the user does not experience any material restriction on his breathing.
The capsule 26 1s filled and sealed at the place of manufacture. It may advantageously be shipped with its lower end covered with a rubber cap 46, which, in undistorted condition, has its bottom dished upward as indicated at 48 in Figure so that pushing thecap home on the lower end of the capsule will stress the bottom 48 and cause it to remain gently pressed upward against the screen 30 until the cap is removed preparatory to using the capsule.
The upper portion of the capsule is shaped for convenient handling by the user. I have illustrated a plastic capsule which may be formed initially with a middle diaphragm 50 at the top of the capsule proper 26, and substantially arcuate closed wall sections rising above the diaphragm 50 and of slightly larger diameter than that of the capsule proper 26 to dene an abutment shoulder 52 to engage the grommet 26. The
4 segmental upper portions may then be heated slightly and gently pressed over to dene an openended arch 54, the ends of which may conveniently be engaged by the finger tips of the user when inserting or withdrawing the capsule.
I prefer to curve the passage 32 in a generally arcuate path down and in toward the user to reduce the overall length of the device,
By Varying the neness of the powder and the mesh of the screen 30 various powdered medicaments can be administered at various rates. With sodium penicillin I prefer to use a screen of about 60 mesh and it is not hard to granulate the powder by trial and error to a grain size such that an administration of 100,000 units is easily accomplishedby normal breathing, in from three to six minutes. I have also found that smoother and more accurate mechanical action can be secured by mixing the penicillin with at least a little other material intended to function as a diluent or vehicle. Specifically, 100,000 units of graular penicillin represents about 90 milligrams of material and the addition to the charge of about 25 milligrams of sulfanilamide makes up into a combined powder that secures materially better and more accurate mechanical functioning. A patient inhaling such a charge will receive a full normal dose of penicillin but only about 10% of a normal dose of sulfanilamide. It will be obvious that the charge may include various combinations of medicaments with or without completely inert vehicles.
Because the energy of the users breath actuates the timed discharge, there is no other instrumentality with which any synchronism needs to be maintained. Further, because there is no extraneous power imposed on the ingoing air stream, the patients natural and normal lung movements are not disturbed and upset yby being pushed or pulled in a way that is always uncomfortable and frequently unexpected and bad l for the morale of the patient.
Others may readily adapt the invention for use under various conditions of service by empolying one or more of the novel features involved, or equivalents thereof. As at present advised with respect to the apparent scope of my invention, I desire to claim the following subject mattei'.
I claim:
1. Equipment for introducing an air-borne powdered medicament into body cavities, which comprises: a rigid transparent plastic body dening a chamber; said chamber being formed with one end outlet shaped to be gripped between the teeth of the user; said chamber having a lateral outlet positioned below the users nostrils when said first outlet is gripped by the users teeth; a flexible branched conduit having a single lower opening fitting said second chamber outlet, and double upper openings of va size to t into the nostrils of the user; said upper openings being deflnedby flexible material; a tubular inlet at the end of the chamber opposite said first outlet; a ball of diameter sufficient to substantially close said tubular inlet; said tubular inlet being inclined so that the ball normally resides at the intake end of said inlet; an obstruction at the intake end of said inlet end to prevent egress of said ball; an obstruction at the discharge end of said tubular inlet to prevent discharge of said ball into said chamber; said tubular inlet having lateral vent opening adjacent its discharge end positioned to be uncovered by said ball; a removable container for medicament;
-socket means in the wall oi said chamber for receiving and holding said container in a position to. be struck by said ball at-the end of its inward movement; said container having a foraminated bottom; and a charge of powdered medicament in said container of grain size small enough to deliver an increment of medicament through said foraminated bottom each time said ball strikes said container at the beginning of inhalation; a return flow discharge opening in said chamber, and a quick-acting check valve permitting gas to issue from said chamber during exhalation but closing at the beginning of inhalation to compel the air inhaled to enter through said tubular inlet.
2. Equipment for introducing an air-borne medicament into body cavities, which'comprises: a rigid transparent plastic body dening a chamlber; said chamber being formed with one end outlet shaped to deliver uid to the mouth of the user: said chamber having a lateral outlet positioned below the users nostrils when said rst outlet is gripped by the users teeth; a conduit means for delivering gas from said second chamber outlet into the nostrils of the user; a tubular inlet at the end of the chamber opposite said first outlet: a ball of diameter sufilcient to substantially close said tubular inlet; said tubular inlet being inclined so that the ball normally resides at the intake end of said inlet; an obstruction at the intake end of said inlet end to prevent egress of said ball; an obstruction at the discharge end of said tubular inlet to prevent discharge of said ball into said chamber; said tubular inlet having lateral vent openings adjacent its discharge end positioned to be uncovered by said ball; a removable container for medicament; socket means in the wall of said chamber for receiving said container in a position to be. struck by said ball at the end of its inward movement: said container having a foraminated bottom; and a charge of powdered -medicament in said container of grain size small enough to deliver an increment of medicament through said ioraminated bottom each time said ball strikes said container at the beginning of inhalation; a. return flow discharge opening in said chamber: and a quick-acting check valve permitting gas to issue from said chamber during exhalation but closing at the beginning of inhalation to compel .the air inhaled to enter through said tubular inlet.
3. Equipment for introducing' an airborne powdered medicament into body cavities, which comprises: a body dening 'a chamber; said chamber being formed with an outlet shaped to deliver iluid -to the person o! the user; an inlet to said chamber; a medicament container in said chamber having a foraminated Wall; means actuated by the initial flow of inhaled gas through said inlet, for jolting said container to release an increment of medicament through said i'oraminated wall; said chamber being provided with an additional outlet for the exit of gas during exhalation; and an automatic check valve in said additional outlet to prevent inward flow.
MACK R. FIELDS.
REFERENCES CITED The following references are of record in the ille of `this patent:
UNITED STATES PATENTS
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BE483136D BE483136A (en) | 1947-09-04 | 1942-06-15 | |
US772104A US2470297A (en) | 1947-09-04 | 1947-09-04 | Inhalator |
FR59839D FR59839E (en) | 1947-09-04 | 1948-06-10 | Inhaler device |
FR967494D FR967494A (en) | 1947-09-04 | 1948-06-10 | Inhaler device |
NL141155A NL68968C (en) | 1947-09-04 | 1948-06-24 | |
GB21972/48A GB654860A (en) | 1947-09-04 | 1948-08-20 | Improvements in or relating to therapeutic medication |
GB13228/50A GB654872A (en) | 1947-09-04 | 1948-08-20 | Improvements in or relating to therapeutic medication |
CH277150D CH277150A (en) | 1947-09-04 | 1948-09-04 | Container for sprayed product. |
CH278137D CH278137A (en) | 1947-09-04 | 1948-09-04 | Inhaler. |
DEA12922A DE846770C (en) | 1947-09-04 | 1949-01-01 | Medicine containers |
DEP30173A DE845385C (en) | 1947-09-04 | 1949-01-01 | Device for administering medicaments by inhalation |
BE489055D BE489055A (en) | 1947-09-04 | 1949-05-16 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US772104A US2470297A (en) | 1947-09-04 | 1947-09-04 | Inhalator |
Publications (1)
Publication Number | Publication Date |
---|---|
US2470297A true US2470297A (en) | 1949-05-17 |
Family
ID=25093930
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US772104A Expired - Lifetime US2470297A (en) | 1947-09-04 | 1947-09-04 | Inhalator |
Country Status (7)
Country | Link |
---|---|
US (1) | US2470297A (en) |
BE (2) | BE483136A (en) |
CH (2) | CH278137A (en) |
DE (2) | DE845385C (en) |
FR (2) | FR967494A (en) |
GB (2) | GB654860A (en) |
NL (1) | NL68968C (en) |
Cited By (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2503732A (en) * | 1949-01-28 | 1950-04-11 | Wyeth Corp | Inhalator |
US2590832A (en) * | 1949-03-29 | 1952-03-25 | Frederick M Turnbull | Inhaler with closure |
US2641254A (en) * | 1948-10-18 | 1953-06-09 | Frederick M Turnbull | Applicator |
US2722935A (en) * | 1949-03-22 | 1955-11-08 | Robert E Thompson | Powder dispenser |
US2809634A (en) * | 1956-08-07 | 1957-10-15 | Murai Hirotada | Inhaling and sniffing pipe |
US3508543A (en) * | 1967-04-27 | 1970-04-28 | Orlando T Aulicono | Mouth-to-mouth and nose resuscitation device |
US4722326A (en) * | 1985-11-04 | 1988-02-02 | Ruderian Max J | Vibratory therapeutic device |
US4846168A (en) * | 1986-12-05 | 1989-07-11 | Mect Corporation | Inhaler |
US4886493A (en) * | 1987-10-22 | 1989-12-12 | Jordan Yee | Medical applicator process |
EP0626180A1 (en) | 1993-05-28 | 1994-11-30 | PAUL RITZAU PARI-WERK GmbH | Mouthpiece for inhalation therapy apparatus |
US5669378A (en) * | 1995-12-21 | 1997-09-23 | Pera; Ivo | Inhaling device |
US5676643A (en) * | 1995-02-13 | 1997-10-14 | The Procter & Gamble Company | Dispenser for friably releasing dry particulate medicaments |
US5683361A (en) * | 1991-12-10 | 1997-11-04 | Novo Nordisk A/S | Disposable dispenser for powder |
US5797392A (en) * | 1996-01-22 | 1998-08-25 | Direct-Haler A/S | Inhaler |
WO1998041256A2 (en) * | 1997-03-14 | 1998-09-24 | Astra Aktiebolag (Publ) | Inhalation device |
US5989217A (en) * | 1996-03-21 | 1999-11-23 | Unisia Jecs Corporation | Medicine administering device for nasal cavities |
US6055979A (en) * | 1996-04-02 | 2000-05-02 | Ing. Erich Pfeiffer Gmbh | Dosing and discharging device for flowable media including powder/air dispersions |
US6065471A (en) * | 1994-09-16 | 2000-05-23 | Laboratoire Glaxo Wellcome | Inhalation device |
WO2000051672A1 (en) * | 1999-03-03 | 2000-09-08 | Optinose As | Nasal delivery device |
US6230707B1 (en) * | 1993-07-30 | 2001-05-15 | Hoerlin Ernst | Powder inhaler |
US20010027790A1 (en) * | 2000-02-01 | 2001-10-11 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
WO2002068030A2 (en) * | 2001-02-26 | 2002-09-06 | Optinose As | Nasal devices |
US6513519B2 (en) | 1999-12-22 | 2003-02-04 | Pari Gmbh Spezialsten Fur Effective Inhalation | Inhalation atomizer with a one-piece valve element |
US6606990B2 (en) | 1998-01-16 | 2003-08-19 | Pari Gmbh Spezialisten Fur Effektive Inhalation | Mouth piece for inhalation therapy units |
WO2003084591A1 (en) * | 2002-04-04 | 2003-10-16 | Optinose As | Nasal devices |
WO2003090812A2 (en) * | 2002-04-25 | 2003-11-06 | Optinose As | Nasal devices |
WO2004004814A2 (en) * | 2002-07-02 | 2004-01-15 | Optinose As | Nasal devices |
US20060054165A1 (en) * | 2002-12-19 | 2006-03-16 | Scadds Incorporated | Self contained aerosol dual delivery system (SCADDS) |
US20060081246A1 (en) * | 2002-01-24 | 2006-04-20 | Joachim Goede | Pharmaceutical powder cartridge, and inhaler equipped with same |
US20100012120A1 (en) * | 2006-12-22 | 2010-01-21 | Laboratorios Almirall, S.A. | Inhalation device for drugs in powder form |
WO2011151479A2 (en) * | 2010-05-19 | 2011-12-08 | Javier Ernesto Maselli | Respirator - cpr resuscitation device |
US20120006323A1 (en) * | 2001-06-12 | 2012-01-12 | Optinose As | Nasal devices |
US20130032145A1 (en) * | 2008-05-01 | 2013-02-07 | Dan Adler | Dry powder inhaler |
WO2014004400A2 (en) * | 2012-06-28 | 2014-01-03 | The Governt. Of The Usa As Represented By The Secretary Of The Department Of Health & Human Services | Nasal dry powder delivery system for vaccines and other treatment agents |
US20140096770A1 (en) * | 2012-10-05 | 2014-04-10 | Lily A. Neff | Salt puffer |
US20150013677A1 (en) * | 2012-02-24 | 2015-01-15 | Optinose As | Nasal Delivery Devices |
EP2965775A1 (en) * | 2008-01-24 | 2016-01-13 | Vectura Delivery Devices Limited | Inhaler |
US20160228663A1 (en) * | 2014-10-27 | 2016-08-11 | Human Design Medical, Llc | Nasal mask for use in various positive airway pressure supply systems |
USD776252S1 (en) * | 2012-07-17 | 2017-01-10 | Rhinosystems, Inc. | Nasal irrigation device |
US9883932B2 (en) | 2009-10-19 | 2018-02-06 | Aircom Manufacturing, Inc. | Transdermal dispensing apparatus and methods |
US10478574B2 (en) * | 2006-01-19 | 2019-11-19 | Optinose As | Nasal administration |
US20200268999A1 (en) * | 2019-02-27 | 2020-08-27 | Mackay Memorial Hospital | Respiratory mask |
US10765829B2 (en) | 2006-07-25 | 2020-09-08 | Optinose As | Delivery of gases to the nasal airway |
US11065410B1 (en) * | 2021-02-01 | 2021-07-20 | Leonard Feld | Dental appliance using airway dialation for treating covid related breathing disorders |
US11083858B2 (en) * | 2007-10-03 | 2021-08-10 | Optinose As | Nasal delivery devices |
US11291751B2 (en) | 2006-11-06 | 2022-04-05 | Aardvark Medical, Inc. | Irrigation and aspiration device and methods |
USD950711S1 (en) * | 2021-06-11 | 2022-05-03 | ChongQing Moffy Innovation Technology Co., Ltd. | Nasal irrigator |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1047385B (en) * | 1952-03-08 | 1958-12-24 | Armour & Co | Powder atomizer with an exchangeable powder container |
FI69963C (en) * | 1984-10-04 | 1986-09-12 | Orion Yhtymae Oy | DOSERINGSANORDNING |
AT384552B (en) * | 1985-08-01 | 1987-12-10 | Hurka Wilhelm | INHALATION DEVICE FOR DOSING AND DISTRIBUTING SOLID BODIES INTO THE BREATHING AIR |
US5176132A (en) * | 1989-05-31 | 1993-01-05 | Fisons Plc | Medicament inhalation device and formulation |
WO1992002268A1 (en) * | 1990-07-27 | 1992-02-20 | Bon F Del | Inhalation device |
CA2093809A1 (en) * | 1991-08-15 | 1993-02-16 | Franco Del Bon | Inhaler |
AT398277B (en) * | 1992-12-11 | 1994-11-25 | Hurka Wilhelm | INHALATION DEVICE |
DE4319514C2 (en) * | 1993-06-14 | 2003-06-18 | Sofotec Gmbh & Co Kg | powder inhaler |
GB2299034A (en) * | 1994-09-14 | 1996-09-25 | Nippon Denso Co | Deodorizing filter |
DE19522415C2 (en) * | 1995-06-21 | 2003-12-04 | Sofotec Gmbh & Co Kg | Drug powder cartridge with integrated dosing device and powder inhaler with means for actuating the dosing device of the drug powder cartridge |
ATE209518T1 (en) * | 1995-06-21 | 2001-12-15 | Asta Medica Ag | MEDICINAL POWDER CARTRIDGE WITH INTEGRATED DOSING DEVICE AND POWDER INHALER |
DE10202940A1 (en) | 2002-01-24 | 2003-07-31 | Sofotec Gmbh & Co Kg | Cartridge for a powder inhaler |
AU2005263486B2 (en) | 2004-07-16 | 2011-05-12 | Astrazeneca Ab | Inhaler for the administration of powdered pharmaceuticals, and a powder cartridge system for use with this inhaler |
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DE471490C (en) * | 1931-08-12 | Karl Zeyen | Device for atomizing flour-like substances | |
US2214032A (en) * | 1939-06-23 | 1940-09-10 | Walter B Stewart | Apparatus for administering powdered aluminum |
-
1942
- 1942-06-15 BE BE483136D patent/BE483136A/xx unknown
-
1947
- 1947-09-04 US US772104A patent/US2470297A/en not_active Expired - Lifetime
-
1948
- 1948-06-10 FR FR967494D patent/FR967494A/en not_active Expired
- 1948-06-10 FR FR59839D patent/FR59839E/en not_active Expired
- 1948-06-24 NL NL141155A patent/NL68968C/xx active
- 1948-08-20 GB GB21972/48A patent/GB654860A/en not_active Expired
- 1948-08-20 GB GB13228/50A patent/GB654872A/en not_active Expired
- 1948-09-04 CH CH278137D patent/CH278137A/en unknown
- 1948-09-04 CH CH277150D patent/CH277150A/en unknown
-
1949
- 1949-01-01 DE DEP30173A patent/DE845385C/en not_active Expired
- 1949-01-01 DE DEA12922A patent/DE846770C/en not_active Expired
- 1949-05-16 BE BE489055D patent/BE489055A/xx unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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DE471490C (en) * | 1931-08-12 | Karl Zeyen | Device for atomizing flour-like substances | |
US2214032A (en) * | 1939-06-23 | 1940-09-10 | Walter B Stewart | Apparatus for administering powdered aluminum |
Cited By (119)
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US2641254A (en) * | 1948-10-18 | 1953-06-09 | Frederick M Turnbull | Applicator |
US2503732A (en) * | 1949-01-28 | 1950-04-11 | Wyeth Corp | Inhalator |
US2722935A (en) * | 1949-03-22 | 1955-11-08 | Robert E Thompson | Powder dispenser |
US2590832A (en) * | 1949-03-29 | 1952-03-25 | Frederick M Turnbull | Inhaler with closure |
US2809634A (en) * | 1956-08-07 | 1957-10-15 | Murai Hirotada | Inhaling and sniffing pipe |
US3508543A (en) * | 1967-04-27 | 1970-04-28 | Orlando T Aulicono | Mouth-to-mouth and nose resuscitation device |
US4722326A (en) * | 1985-11-04 | 1988-02-02 | Ruderian Max J | Vibratory therapeutic device |
US4846168A (en) * | 1986-12-05 | 1989-07-11 | Mect Corporation | Inhaler |
US4886493A (en) * | 1987-10-22 | 1989-12-12 | Jordan Yee | Medical applicator process |
US5683361A (en) * | 1991-12-10 | 1997-11-04 | Novo Nordisk A/S | Disposable dispenser for powder |
EP0626180A1 (en) | 1993-05-28 | 1994-11-30 | PAUL RITZAU PARI-WERK GmbH | Mouthpiece for inhalation therapy apparatus |
US6230707B1 (en) * | 1993-07-30 | 2001-05-15 | Hoerlin Ernst | Powder inhaler |
US6065471A (en) * | 1994-09-16 | 2000-05-23 | Laboratoire Glaxo Wellcome | Inhalation device |
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US6220243B1 (en) | 1994-09-16 | 2001-04-24 | Laboratoire Glaxo Wellcome | Inhalation device |
US5676643A (en) * | 1995-02-13 | 1997-10-14 | The Procter & Gamble Company | Dispenser for friably releasing dry particulate medicaments |
US5669378A (en) * | 1995-12-21 | 1997-09-23 | Pera; Ivo | Inhaling device |
US5797392A (en) * | 1996-01-22 | 1998-08-25 | Direct-Haler A/S | Inhaler |
US5989217A (en) * | 1996-03-21 | 1999-11-23 | Unisia Jecs Corporation | Medicine administering device for nasal cavities |
US6055979A (en) * | 1996-04-02 | 2000-05-02 | Ing. Erich Pfeiffer Gmbh | Dosing and discharging device for flowable media including powder/air dispersions |
US20050194008A1 (en) * | 1997-03-14 | 2005-09-08 | Astrazeneca Ab, A Swedish Corporation | Inhalation device |
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US20040065325A1 (en) * | 1997-03-14 | 2004-04-08 | Astrazeneca Ab, A Swedish Corporaion | Inhalation device |
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US11260190B1 (en) * | 2021-02-01 | 2022-03-01 | Leonard Feld | Dental appliance using airway dialation for treating COVID related breathing disorders |
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Also Published As
Publication number | Publication date |
---|---|
DE846770C (en) | 1952-08-18 |
FR59839E (en) | 1954-08-23 |
CH277150A (en) | 1951-08-15 |
BE489055A (en) | 1949-06-15 |
GB654872A (en) | 1951-07-04 |
NL68968C (en) | 1951-06-15 |
CH278137A (en) | 1951-09-30 |
BE483136A (en) | 1942-06-30 |
GB654860A (en) | 1951-07-04 |
FR967494A (en) | 1950-11-03 |
DE845385C (en) | 1952-11-04 |
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