US2162738A - Extracting nicotine from tobacco - Google Patents
Extracting nicotine from tobacco Download PDFInfo
- Publication number
- US2162738A US2162738A US159714A US15971437A US2162738A US 2162738 A US2162738 A US 2162738A US 159714 A US159714 A US 159714A US 15971437 A US15971437 A US 15971437A US 2162738 A US2162738 A US 2162738A
- Authority
- US
- United States
- Prior art keywords
- nicotine
- weight
- tobacco
- ammonia
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Definitions
- This invention relates to the art of extracting nicotine from vegetablematerial, particularly from tobacco.
- One of the objects of this invention is to provide a method for the recovery, of practically all the nicotine contained in uncured and cured tobacco. Another object of this invention is to provide an economical method for the extraction of nicotine from tobacco. Still another object of this invention is to provide a process for the removal of nicotine'from tobacco which results in the production of a residue which may be used ,without further chemical treatment as a fertilizer or for incorporation in fertilizer mixtures to obtain the maximum advantage of the valuable constituentscontained therein. Other objects of this invention include the provision for an economical method for extracting nicotine from vegetable material containing the same. ,T 1 s Unmarketable grades of leafv tobacco, low grade leaf tobacco.
- leaf tobacco may be processed more extensively to recover the nicotine contained therein provided the cost of extraction is reduced and the consumption of the nicotine increased correspondingly thereby.
- the cost of the production of the nicotine is dependent, not only on the cost of the raw materials and the cost of the unit operations involved, but on the value of the by-products obtained. Numerous proposals have been made for the extraction of nic otine from tobacco involving the use of heat treatment, waterv or steam treatment, alkali treatment, and treatment with hydrocarbons,
- otine solution is used over again in the process and the residue, containing valuable nitrogen and potassium compounds as well as organic matter, is of such quality that it can be used in large proportions as a fertilizer or a fertilizer mixture.
- ammonium hydroxide containing 22% by weight of NH3
- the ammonia treated material was thereupon immediately extracted with 6 successive portions of naphtha of 109 parts by Weight each at a temperature of C. to remove the nicotine. extract, resulting in 94.7% by weight of the total nicotine being extracted.
- 3 parts by Weight of ammonium hydroxide, containing 22% by weight of NH3, and the mixture agitated for 15 minutes with a temperature of is to be'extracted may be either leaf or stem.
- Vegetable material such as leaf tobacco, will ordinarily contain 12 to 18% of water.
- Such relatively low water content material may be gener- 'erally shredded or disintegrated without mechanical difiiculties and it is, therefore, preferable to so disintegrate'such material prior to making any adjustmentof the water content.
- the water content ofthe material may then be adjusted up to approximately 45%, although it is generally preferable-to maintain this range between 16 and
- the vegetable material so prepared is then treated with ammonia, with the amount of the ammonia equal to at least 1 mol for each mol of the nicotine present in the vegetable material and, preferably, 2 mols of ammonia for each mol
- the treatment with ammonia is most effective at sup-eratmospheric temperatures, ranging from 30 to more than 100 C.
- the ammonia treatment may be carried out at atmospheric or superatmospheric pressure.
- the ammonia may be admitted as anhydrous ammonia or as an aqueous solution.
- the latter ispreferable and when it is used the amount of Water in the aqueous ammonia solution is taken into account as supplying a portion of the water required for the adjustment of the Water content to'the desired value.
- anhydrous ammonia it may be added either to the moisture conditioned vegetable material alone or the latter in contact with the solvent used for the extraction of the nicotine.
- the ammonia-treated vegetable material is ex- 7 tracted, preferably immediately, after the period of ammonia treatment corresponding to the temperature of the treatment with a suitable solvent.
- the solvent most suitable for this purpose is a hydrocarbon solvent which may be a single hydrocarbon or a mixture of hydrocarbons.
- the latter is generally used, in which case it is preferable to have a mixture having a relatively short distillation range with a high initial boiling point and a low maximum boiling point.
- a hydrocarbon mixture such as fighting grade aviation gasoline or a short distillation range naphtha, is particularly suitable for this purpose, although gasoline and kerosene may be used for this purpose.
- the latter two present some diifioulty in removing higher boiling traces from the residue.
- the extraction may be carried out using gaseous hydrocarbona such as propane or butane, in the liquid phase. However, this is not ordinarily required in the preparation of the commercial grade of nicotine products, such as nicotine or nicotine compounds.
- Other solvent such as alcohols, ethers, esters, halogenatedhydrocarbons or ketones may be used for the extraction but the advantages incident to their use do not ordinarily justify the increased costs incident to their use.
- the nicotine maybe separated from the extract by any suitable means but it is ordinarily preferred to use an aqueous solution of a mineral acid for this purpose.
- An aqueous solution of sulfuric acid is suitable, and with the proper adjustment with the amount of the concentrate H used, can be used to produce a solution oontaining approximately 40% by weight of nicotine sulfate.
- the step which comprises treating the extract with an aqueous solution of sulfuric acid'and nicotine sulfate.
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Extraction Or Liquid Replacement (AREA)
Description
Patented June 20, 1939 No Drawing.
Application August "18, 1937,
Serial No. 159,714
1 Claim.
(Granted under the act of 'March 3, 1883, as amended April 30, 1928; 370 O. G. 757') The invention hereinv described may be manufactured and used by or for the Government for governmental purposes without the payment to me of any royalty thereon.
This invention relates to the art of extracting nicotine from vegetablematerial, particularly from tobacco.
One of the objects of this invention is to provide a method for the recovery, of practically all the nicotine contained in uncured and cured tobacco. Another object of this invention is to provide an economical method for the extraction of nicotine from tobacco. Still another object of this invention is to provide a process for the removal of nicotine'from tobacco which results in the production of a residue which may be used ,without further chemical treatment as a fertilizer or for incorporation in fertilizer mixtures to obtain the maximum advantage of the valuable constituentscontained therein. Other objects of this invention include the provision for an economical method for extracting nicotine from vegetable material containing the same. ,T 1 s Unmarketable grades of leafv tobacco, low grade leaf tobacco. or even asurplus of high 'grade marketable, leaf tobaccomay be processed more extensively to recover the nicotine contained therein provided the cost of extraction is reduced and the consumption of the nicotine increased correspondingly thereby. The cost of the production of the nicotine is dependent, not only on the cost of the raw materials and the cost of the unit operations involved, but on the value of the by-products obtained. Numerous proposals have been made for the extraction of nic otine from tobacco involving the use of heat treatment, waterv or steam treatment, alkali treatment, and treatment with hydrocarbons,
either separately or in a variety of combinations of process steps. The net result has been that either the material is rendered difficult to handle during the process, excessive quantities of unrecoverable reagents have been required, the residue is of such nature that it required further processing which was uneconomical or could not be incorporated with other materialsv in more than small proportions due to its detrimental'effeet, or the recovery of the nicotine is low.
I have discovered a, process for extracting nicotine from vegetable material, particularly from tobacco, by adjusting the water content of the tobacco, by treating the tobacco so conditioned with ammonia for a short period of time, by extracting the ammonia treated material with a liquid, nonaqueous solvent in the liquid phase, and by separating, the nicotine from the solvent extract. The traces of solvent are separated from the extracted vegetable material and, together with the solvent separated from the nicare given below:
otine solution, is used over again in the process and the residue, containing valuable nitrogen and potassium compounds as well as organic matter, is of such quality that it can be used in large proportions as a fertilizer or a fertilizer mixture.
Several examples of the operation of my process, with the extent of the extraction obtained,
'1. 100 parts by weight of high grade dark fired leaf tobacco, containing 4.03% by Weight of nicotine and 12.7% by weight of water, and cut to pass an- 8 mesh screen, were conditioned by adding 20.3 parts by weight of saturated steam. After standing for 30 minutes, 5.8 parts.
by weight of ammonium hydroxide, containing 22% by weight of NH3, were added to the conditioned tobacco and the mixture agitated for 15 minutes with a temperature of 30 C, maintained. The ammonia treated material was thereupon immediately extracted with 6 successive portions of naphtha of 109 parts by Weight each at a temperature of C. to remove the nicotine. extract, resulting in 94.7% by weight of the total nicotine being extracted.
2. parts by weight of the same high grade dark fired leaf tobacco, used in 1 above, were conditioned by adding 10 parts by weight of water followed by thorough agitation. After one minute 4.6 parts by weight of ammonium hydroxide, containing 22% by weight of NH3, were added to the conditioned tobacco and the mixture agitated for 14 minutes with a temperature of 30 C. maintained. Theammonia treated ma terial was thereupon immediately extracted with 6 successive portions of fighting grade aviation gasoline of parts by weight each at a temperature of 75 C. to remove the nicotine. The
nicotine was separated from the extract, result-,
ing in 96.1% by weight of the total nicotine being extracted.
3. 100 parts by weight of another dark fired leaf tobacco, containing 3.45% by weight of nicotine and 18.43% by Weight of, water, and cut to pass an 8 mesh screen, were treated with 3.9 parts by weight of ammonium hydroxide, containing 22% by weight of NH3, and the mixture agitated for 15 minutes with a temperature of 60 C. maintained. The ammonia treated material was thereupon immediately extracted with 6 successive portions of naphtha of 156 parts by weight each at a temperature of 60 C. to remove the nicotine. The nicotine was separated from the extract, resulting in 94.7% by weight of the total nicotine being extracted.
I 4. 100 ;parts by, weight of still another dark The nicotine was separated from the 30 C. maintained. The ammonia treated material was thereupon immediately extracted with 6 successive portions of naphthaof 1 56 parts by W of nicotine. present.
3 parts by Weight of ammonium hydroxide, containing 22% by weight of NH3, and the mixture agitated for 15 minutes with a temperature of is to be'extracted may be either leaf or stem. The
material should be preferably shredded or coarsely ground, since the finely ground material presents additional mechanical difficulties in treatment. My process is effective for the extraction of nicotine from any vegetable material containing the'same and particularly effective for the extraction of nicotine from Nicotiana. rustz'ca and Nicotiana 'tabacum.
Vegetable material, such as leaf tobacco, will ordinarily contain 12 to 18% of water. Such relatively low water content material may be gener- 'erally shredded or disintegrated without mechanical difiiculties and it is, therefore, preferable to so disintegrate'such material prior to making any adjustmentof the water content. The water content ofthe material may then be adjusted up to approximately 45%, although it is generally preferable-to maintain this range between 16 and The vegetable material so prepared is then treated with ammonia, with the amount of the ammonia equal to at least 1 mol for each mol of the nicotine present in the vegetable material and, preferably, 2 mols of ammonia for each mol The treatment with ammonia is most effective at sup-eratmospheric temperatures, ranging from 30 to more than 100 C.
with 60C. preferred. This temperature may be reached by adjusting the water content With steam or by heating the Water content adjusted tobacco prior to the ammonia treatment. In any event, thetime for treatment for the ammonia. is limited within 'a critical range of substantially 3to 15 minutes, respectively, for the range of 80 to 30 C., respectively. The ammonia treatment may be carried out at atmospheric or superatmospheric pressure.
The ammonia may be admitted as anhydrous ammonia or as an aqueous solution. The latter ispreferable and when it is used the amount of Water in the aqueous ammonia solution is taken into account as supplying a portion of the water required for the adjustment of the Water content to'the desired value. When anhydrous ammonia is used, it may be added either to the moisture conditioned vegetable material alone or the latter in contact with the solvent used for the extraction of the nicotine.
, The ammonia-treated vegetable material is ex- 7 tracted, preferably immediately, after the period of ammonia treatment corresponding to the temperature of the treatment with a suitable solvent.
The solvent most suitable for this purpose is a hydrocarbon solvent which may be a single hydrocarbon or a mixture of hydrocarbons. The latter is generally used, in which case it is preferable to have a mixture having a relatively short distillation range with a high initial boiling point and a low maximum boiling point. A hydrocarbon mixture, such as fighting grade aviation gasoline or a short distillation range naphtha, is particularly suitable for this purpose, although gasoline and kerosene may be used for this purpose. The latter two present some diifioulty in removing higher boiling traces from the residue. The extraction may be carried out using gaseous hydrocarbona such as propane or butane, in the liquid phase. However, this is not ordinarily required in the preparation of the commercial grade of nicotine products, such as nicotine or nicotine compounds. Other solvent, such as alcohols, ethers, esters, halogenatedhydrocarbons or ketones may be used for the extraction but the advantages incident to their use do not ordinarily justify the increased costs incident to their use.
The nicotine maybe separated from the extract by any suitable means but it is ordinarily preferred to use an aqueous solution of a mineral acid for this purpose. An aqueous solution of sulfuric acid is suitable, and with the proper adjustment with the amount of the concentrate H used, can be used to produce a solution oontaining approximately 40% by weight of nicotine sulfate. When anextract is contacted directly with a solution of sulfuric acid alone, an emulsion which is difficult to separate may be formed if the agitation of the constituents of the mixture is My invention may besummarized as the discovery of those conditions: of temperature, time, moisture content, and ammonia content under which ammonia enters the vegetable particle to liberate'the nicotine from its salts while still enough ammonia remains in the surface Water film to'overcome the partition coefficient between the aqueous solution of free nicotine and a solution of nicotine in the'non-aqueous hydrocarbon, thereby forcing the nicotine from its aqueous phase into the hydrocarbon for solution, with the result'accomplis hed without an excessive use of ammonia'which would otherwise require the expense of recovery of such an excess of ammonia.
It Will be seen, therefore, that this invention actually may be carried out by the modification of certain details without departing from its spirit or scope.
I claim:
In the process of extracting nicotine from a -material containing the same which comprises treating the material with a nonaqueous solvent for the nicotine and separating the nicotine from the solvent extract, the step which comprises treating the extract with an aqueous solution of sulfuric acid'and nicotine sulfate.
CLARENCE E. MCCOY.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US159714A US2162738A (en) | 1937-08-18 | 1937-08-18 | Extracting nicotine from tobacco |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US159714A US2162738A (en) | 1937-08-18 | 1937-08-18 | Extracting nicotine from tobacco |
Publications (1)
Publication Number | Publication Date |
---|---|
US2162738A true US2162738A (en) | 1939-06-20 |
Family
ID=22573699
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US159714A Expired - Lifetime US2162738A (en) | 1937-08-18 | 1937-08-18 | Extracting nicotine from tobacco |
Country Status (1)
Country | Link |
---|---|
US (1) | US2162738A (en) |
Cited By (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2525785A (en) * | 1949-12-05 | 1950-10-17 | Feinstein Louis | Process for extracting alkaloidals from plants with aqueous ammoniaethylene dichloride mixture |
US3110315A (en) * | 1960-07-27 | 1963-11-12 | Lendvai Andrew | Denicotinization of tobacco |
US4215706A (en) * | 1978-10-13 | 1980-08-05 | Loew's Theatres, Inc. | Nicotine transfer process |
US4628947A (en) * | 1985-07-05 | 1986-12-16 | Philip Morris Incorporated | Process for modifying the flavor characteristics of bright tobacco |
US5018540A (en) * | 1986-12-29 | 1991-05-28 | Philip Morris Incorporated | Process for removal of basic materials |
US5497792A (en) * | 1987-11-19 | 1996-03-12 | Philip Morris Incorporated | Process and apparatus for the semicontinuous extraction of nicotine from tobacco |
US20040248946A1 (en) * | 2001-12-10 | 2004-12-09 | Knight Joseph R | Beverage treated with nicotine |
WO2013109931A2 (en) | 2012-01-20 | 2013-07-25 | Altria Client Services Inc. | Oral product |
WO2013109961A1 (en) | 2012-01-20 | 2013-07-25 | Altria Client Services Inc. | Oral product |
WO2014159673A2 (en) | 2013-03-14 | 2014-10-02 | Altria Client Services Inc. | Soft oral product |
WO2014186288A1 (en) | 2013-05-13 | 2014-11-20 | Altria Client Services Inc. | Oral product |
WO2015051308A1 (en) | 2013-10-03 | 2015-04-09 | Altria Client Services Inc. | Lozenge |
WO2015051306A1 (en) | 2013-10-03 | 2015-04-09 | Altria Client Services Inc. | Dissolvable chewable tablet |
US9351936B2 (en) | 2013-10-03 | 2016-05-31 | Altria Client Services Llc | Nicotine lozenge |
WO2016124932A1 (en) | 2015-02-05 | 2016-08-11 | British American Tobacco (Investments) Limited | Method |
WO2016128750A1 (en) | 2015-02-13 | 2016-08-18 | British American Tobacco (Investments) Limited | Method |
US9521864B2 (en) | 2013-07-19 | 2016-12-20 | Altria Client Services Llc | Methods and systems for incorporating nicotine into oral products |
WO2017223129A1 (en) | 2016-06-22 | 2017-12-28 | North Carolina State University | Method for increasing nitrogen-use efficiency and or nitrogen-utilisation efficiency in plants |
US9854831B2 (en) | 2012-01-20 | 2018-01-02 | Altria Client Services Llc | Oral product |
US9854830B2 (en) | 2012-01-20 | 2018-01-02 | Altria Client Services Llc | Oral tobacco product |
US9884015B2 (en) | 2012-01-20 | 2018-02-06 | Altria Client Services Llc | Oral product |
US9986756B2 (en) | 2012-01-20 | 2018-06-05 | Altria Client Services Llc | Exhausted-tobacco oral product |
US9999243B2 (en) | 2013-10-03 | 2018-06-19 | Altria Client Services Llc | Exhausted tobacco lozenge |
WO2018126262A2 (en) | 2016-12-30 | 2018-07-05 | Altria Client Services Llc | Smokeless products containing non-tobacco plant materials |
WO2018148169A1 (en) | 2017-02-07 | 2018-08-16 | University Of Kentucky Research Foundation | Method |
US10105320B2 (en) | 2013-10-03 | 2018-10-23 | Altria Client Services | Soluble fiber lozenge |
WO2018237107A1 (en) | 2017-06-23 | 2018-12-27 | University Of Kentucky Research Foundation | Method |
WO2019012261A1 (en) | 2017-07-11 | 2019-01-17 | British American Tobacco (Investments) Limited | Hybrid tobacco plants from crosses between flue-cured and air-cured tobacco types |
US10244786B2 (en) | 2013-10-03 | 2019-04-02 | Altria Client Services Llc | Tobacco lozenge |
WO2020025963A2 (en) | 2018-08-02 | 2020-02-06 | British American Tobacco (Investments) Limited | Method |
WO2020089645A1 (en) | 2018-11-02 | 2020-05-07 | British American Tobacco (Investments) Limited | Method of modulating the alkaloid content of a plant |
WO2020099875A1 (en) | 2018-11-16 | 2020-05-22 | British American Tobacco (Investments) Limited | Methods and means for modifying the alkaloid content of plants |
WO2020152466A1 (en) | 2019-01-23 | 2020-07-30 | British American Tobacco (Investments) Limited | Method for decreasing the alkaloid content of a tobacco plant |
WO2020229830A1 (en) | 2019-05-14 | 2020-11-19 | British American Tobacco (Investments) Limited | Method |
WO2021001659A1 (en) | 2019-07-03 | 2021-01-07 | British American Tobacco (Investments) Limited | Method for modifying alkaloid content in plants |
WO2021001658A1 (en) | 2019-07-03 | 2021-01-07 | British American Tobacco (Investments) Limited | Method for modulating the alkaloid content of a tobacco plant |
WO2021127162A1 (en) | 2019-12-20 | 2021-06-24 | Juul Labs, Inc. | Hydrated ionic clay and tobacco material compositions |
WO2021205000A2 (en) | 2020-04-09 | 2021-10-14 | R.J. Reynolds Tobacco Company | Method |
WO2023148475A1 (en) | 2022-02-04 | 2023-08-10 | Nicoventures Trading Limited | Method of modulating alkaloid content in tobacco plants |
WO2023148478A1 (en) | 2022-02-03 | 2023-08-10 | Nicoventures Trading Limited | Method of modulating alkaloid content in tobacco plants |
WO2023148476A1 (en) | 2022-02-03 | 2023-08-10 | Nicoventures Trading Limited | Method of modulating alkaloid content in tobacco plants |
US11771127B2 (en) | 2013-10-03 | 2023-10-03 | Altria Client Services Llc | Chewable dissolvable nicotine tablet |
US11779045B2 (en) | 2013-10-03 | 2023-10-10 | Altria Client Services Llc | Dissolvable-chewable exhausted-tobacco tablet |
WO2023194747A1 (en) | 2022-04-07 | 2023-10-12 | Nicoventures Trading Limited | Method of modulating the alkaloid content of tobacco |
WO2023194746A1 (en) | 2022-04-07 | 2023-10-12 | Nicoventures Trading Limited | Method for modulating the alkaloid content of tobacco |
WO2023199064A1 (en) | 2022-04-14 | 2023-10-19 | Nicoventures Trading Limited | Method of modulating the alkaloid content of tobacco |
WO2023199065A1 (en) | 2022-04-14 | 2023-10-19 | Nicoventures Trading Limited | Method of modulating the alkaloid content of tobacco |
WO2023209373A1 (en) | 2022-04-27 | 2023-11-02 | Nicoventures Trading Limited | Method of modulating the alkaloid content of tobacco |
WO2023209372A1 (en) | 2022-04-27 | 2023-11-02 | Nicoventures Trading Limited | Method of modulating the alkaloid content of tobacco |
US11849752B2 (en) | 2016-12-30 | 2023-12-26 | Altria Client Services Llc | Smokeless products containing non-tobacco plant materials |
US11999960B2 (en) | 2018-02-06 | 2024-06-04 | University Of Kentucky Research Foundation | Method of producing tobacco plants with increased sucrose ester content |
-
1937
- 1937-08-18 US US159714A patent/US2162738A/en not_active Expired - Lifetime
Cited By (89)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2525785A (en) * | 1949-12-05 | 1950-10-17 | Feinstein Louis | Process for extracting alkaloidals from plants with aqueous ammoniaethylene dichloride mixture |
US3110315A (en) * | 1960-07-27 | 1963-11-12 | Lendvai Andrew | Denicotinization of tobacco |
US4215706A (en) * | 1978-10-13 | 1980-08-05 | Loew's Theatres, Inc. | Nicotine transfer process |
US4628947A (en) * | 1985-07-05 | 1986-12-16 | Philip Morris Incorporated | Process for modifying the flavor characteristics of bright tobacco |
US5018540A (en) * | 1986-12-29 | 1991-05-28 | Philip Morris Incorporated | Process for removal of basic materials |
US5497792A (en) * | 1987-11-19 | 1996-03-12 | Philip Morris Incorporated | Process and apparatus for the semicontinuous extraction of nicotine from tobacco |
US20040248946A1 (en) * | 2001-12-10 | 2004-12-09 | Knight Joseph R | Beverage treated with nicotine |
US7435749B2 (en) * | 2001-12-10 | 2008-10-14 | Knight Joseph R | Beverage treated with nicotine |
US10631568B2 (en) | 2012-01-20 | 2020-04-28 | Altria Client Services Llc | Oral product |
US10639275B2 (en) | 2012-01-20 | 2020-05-05 | Altria Client Services Llc | Oral product |
US10959454B2 (en) | 2012-01-20 | 2021-03-30 | Altria Client Services Llc | Oral product |
EP4001355A1 (en) | 2012-01-20 | 2022-05-25 | Altria Client Services LLC | Oral product |
US11369129B2 (en) | 2012-01-20 | 2022-06-28 | Altria Client Services Llc | Oral product |
EP4042882A1 (en) | 2012-01-20 | 2022-08-17 | Altria Client Services LLC | Oral product |
US9872516B2 (en) | 2012-01-20 | 2018-01-23 | Altria Client Services Llc | Oral product |
WO2013109961A1 (en) | 2012-01-20 | 2013-07-25 | Altria Client Services Inc. | Oral product |
US11541001B2 (en) | 2012-01-20 | 2023-01-03 | Altria Client Services Llc | Oral product |
US11864578B2 (en) | 2012-01-20 | 2024-01-09 | Altria Client Services Llc | Oral product |
US10660359B2 (en) | 2012-01-20 | 2020-05-26 | Altria Client Services Llc | Oral product |
WO2013109931A2 (en) | 2012-01-20 | 2013-07-25 | Altria Client Services Inc. | Oral product |
US10602768B2 (en) | 2012-01-20 | 2020-03-31 | Altria Client Services Llc | Oral tobacco product |
US9854831B2 (en) | 2012-01-20 | 2018-01-02 | Altria Client Services Llc | Oral product |
US9854830B2 (en) | 2012-01-20 | 2018-01-02 | Altria Client Services Llc | Oral tobacco product |
US11540554B2 (en) | 2012-01-20 | 2023-01-03 | Altria Client Services Llc | Oral tobacco product |
US9884015B2 (en) | 2012-01-20 | 2018-02-06 | Altria Client Services Llc | Oral product |
US9930909B2 (en) | 2012-01-20 | 2018-04-03 | Altria Client Services Llc | Oral product |
EP3444297A1 (en) | 2012-01-20 | 2019-02-20 | Altria Client Services LLC | Oral product |
US9986756B2 (en) | 2012-01-20 | 2018-06-05 | Altria Client Services Llc | Exhausted-tobacco oral product |
EP3440945A1 (en) | 2012-01-20 | 2019-02-13 | Altria Client Services LLC | Oral product |
US10834960B2 (en) | 2013-03-14 | 2020-11-17 | Altria Client Services Llc | Soft oral product |
US11758938B2 (en) | 2013-03-14 | 2023-09-19 | Altria Client Services Llc | Soft oral product |
US9420827B2 (en) | 2013-03-14 | 2016-08-23 | Altria Client Services Llc | Soft oral product |
WO2014159673A2 (en) | 2013-03-14 | 2014-10-02 | Altria Client Services Inc. | Soft oral product |
US10244787B2 (en) | 2013-03-14 | 2019-04-02 | Altria Client Services Llc | Soft oral product |
WO2014186288A1 (en) | 2013-05-13 | 2014-11-20 | Altria Client Services Inc. | Oral product |
US10183016B2 (en) | 2013-05-13 | 2019-01-22 | Altria Client Services Llc | Oral product |
US10780085B2 (en) | 2013-05-13 | 2020-09-22 | Altria Client Services Llc | Oral product |
US9185931B2 (en) | 2013-05-13 | 2015-11-17 | Altria Client Services Inc. | Oral product |
US11517566B2 (en) | 2013-05-13 | 2022-12-06 | Altria Client Services Llc | Oral product |
US9521864B2 (en) | 2013-07-19 | 2016-12-20 | Altria Client Services Llc | Methods and systems for incorporating nicotine into oral products |
US10349672B2 (en) | 2013-07-19 | 2019-07-16 | Altria Client Services Llc | Methods and systems for incorporating nicotine into oral products |
US11944115B2 (en) | 2013-07-19 | 2024-04-02 | Altria Client Services Llc | Methods and systems for incorporating nicotine into oral products |
EP3622834A1 (en) | 2013-07-19 | 2020-03-18 | Altria Client Services LLC | Methods and systems for incorporating nicotine into oral products |
US11076631B2 (en) | 2013-07-19 | 2021-08-03 | Altria Client Services Llc | Methods and systems for incorporating nicotine into oral products |
US9943511B2 (en) | 2013-10-03 | 2018-04-17 | Altria Client Services Llc | Nicotine lozenge |
US11771127B2 (en) | 2013-10-03 | 2023-10-03 | Altria Client Services Llc | Chewable dissolvable nicotine tablet |
US11849753B2 (en) | 2013-10-03 | 2023-12-26 | Altria Client Services Llc | Tobacco lozenge |
US11779045B2 (en) | 2013-10-03 | 2023-10-10 | Altria Client Services Llc | Dissolvable-chewable exhausted-tobacco tablet |
US10702516B2 (en) | 2013-10-03 | 2020-07-07 | Altria Client Services Llc | Nicotine lozenge |
US9351936B2 (en) | 2013-10-03 | 2016-05-31 | Altria Client Services Llc | Nicotine lozenge |
US10244786B2 (en) | 2013-10-03 | 2019-04-02 | Altria Client Services Llc | Tobacco lozenge |
US11116758B2 (en) | 2013-10-03 | 2021-09-14 | Altria Client Services Llc | Nicotine lozenge |
US9999243B2 (en) | 2013-10-03 | 2018-06-19 | Altria Client Services Llc | Exhausted tobacco lozenge |
WO2015051306A1 (en) | 2013-10-03 | 2015-04-09 | Altria Client Services Inc. | Dissolvable chewable tablet |
WO2015051308A1 (en) | 2013-10-03 | 2015-04-09 | Altria Client Services Inc. | Lozenge |
US11554099B2 (en) | 2013-10-03 | 2023-01-17 | Altria Client Services Llc | Soluble fiber lozenge |
US10925309B2 (en) | 2013-10-03 | 2021-02-23 | Altria Client Sendees LLC | Tobacco lozenge |
US11723904B2 (en) | 2013-10-03 | 2023-08-15 | Altria Client Services Llc | Nicotine lozenge |
EP3881824A1 (en) | 2013-10-03 | 2021-09-22 | Altria Client Services LLC | Lozenge |
US10105320B2 (en) | 2013-10-03 | 2018-10-23 | Altria Client Services | Soluble fiber lozenge |
US10472642B2 (en) | 2015-02-05 | 2019-11-12 | British American Tobacco (Investments) Limited | Method for the reduction of tobacco-specific nitrosamines or their precursors in tobacco plants |
WO2016124932A1 (en) | 2015-02-05 | 2016-08-11 | British American Tobacco (Investments) Limited | Method |
WO2016128750A1 (en) | 2015-02-13 | 2016-08-18 | British American Tobacco (Investments) Limited | Method |
WO2017223129A1 (en) | 2016-06-22 | 2017-12-28 | North Carolina State University | Method for increasing nitrogen-use efficiency and or nitrogen-utilisation efficiency in plants |
US11849752B2 (en) | 2016-12-30 | 2023-12-26 | Altria Client Services Llc | Smokeless products containing non-tobacco plant materials |
WO2018126262A2 (en) | 2016-12-30 | 2018-07-05 | Altria Client Services Llc | Smokeless products containing non-tobacco plant materials |
WO2018148169A1 (en) | 2017-02-07 | 2018-08-16 | University Of Kentucky Research Foundation | Method |
WO2018237107A1 (en) | 2017-06-23 | 2018-12-27 | University Of Kentucky Research Foundation | Method |
US11439115B2 (en) | 2017-07-11 | 2022-09-13 | British American Tobacco (Investments) Limited | Hybrid tobacco plants from crosses between flue-cured and air-cured tobacco types |
WO2019012261A1 (en) | 2017-07-11 | 2019-01-17 | British American Tobacco (Investments) Limited | Hybrid tobacco plants from crosses between flue-cured and air-cured tobacco types |
US11999960B2 (en) | 2018-02-06 | 2024-06-04 | University Of Kentucky Research Foundation | Method of producing tobacco plants with increased sucrose ester content |
WO2020025963A2 (en) | 2018-08-02 | 2020-02-06 | British American Tobacco (Investments) Limited | Method |
WO2020089645A1 (en) | 2018-11-02 | 2020-05-07 | British American Tobacco (Investments) Limited | Method of modulating the alkaloid content of a plant |
WO2020099875A1 (en) | 2018-11-16 | 2020-05-22 | British American Tobacco (Investments) Limited | Methods and means for modifying the alkaloid content of plants |
WO2020152466A1 (en) | 2019-01-23 | 2020-07-30 | British American Tobacco (Investments) Limited | Method for decreasing the alkaloid content of a tobacco plant |
WO2020229830A1 (en) | 2019-05-14 | 2020-11-19 | British American Tobacco (Investments) Limited | Method |
WO2021001658A1 (en) | 2019-07-03 | 2021-01-07 | British American Tobacco (Investments) Limited | Method for modulating the alkaloid content of a tobacco plant |
WO2021001659A1 (en) | 2019-07-03 | 2021-01-07 | British American Tobacco (Investments) Limited | Method for modifying alkaloid content in plants |
WO2021127162A1 (en) | 2019-12-20 | 2021-06-24 | Juul Labs, Inc. | Hydrated ionic clay and tobacco material compositions |
WO2021205000A2 (en) | 2020-04-09 | 2021-10-14 | R.J. Reynolds Tobacco Company | Method |
WO2023148478A1 (en) | 2022-02-03 | 2023-08-10 | Nicoventures Trading Limited | Method of modulating alkaloid content in tobacco plants |
WO2023148476A1 (en) | 2022-02-03 | 2023-08-10 | Nicoventures Trading Limited | Method of modulating alkaloid content in tobacco plants |
WO2023148475A1 (en) | 2022-02-04 | 2023-08-10 | Nicoventures Trading Limited | Method of modulating alkaloid content in tobacco plants |
WO2023194747A1 (en) | 2022-04-07 | 2023-10-12 | Nicoventures Trading Limited | Method of modulating the alkaloid content of tobacco |
WO2023194746A1 (en) | 2022-04-07 | 2023-10-12 | Nicoventures Trading Limited | Method for modulating the alkaloid content of tobacco |
WO2023199064A1 (en) | 2022-04-14 | 2023-10-19 | Nicoventures Trading Limited | Method of modulating the alkaloid content of tobacco |
WO2023199065A1 (en) | 2022-04-14 | 2023-10-19 | Nicoventures Trading Limited | Method of modulating the alkaloid content of tobacco |
WO2023209372A1 (en) | 2022-04-27 | 2023-11-02 | Nicoventures Trading Limited | Method of modulating the alkaloid content of tobacco |
WO2023209373A1 (en) | 2022-04-27 | 2023-11-02 | Nicoventures Trading Limited | Method of modulating the alkaloid content of tobacco |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US2162738A (en) | Extracting nicotine from tobacco | |
US1929441A (en) | Process for obtaining orthophosphoric acid and/or conversion product thereof | |
US2069185A (en) | Manufacture of vanillin from waste sulphite pulp liquor | |
US2478473A (en) | Process of recovering nicotine from nicotine-bearing plant material | |
US2247373A (en) | Making phosphoric acid | |
US4319980A (en) | Method for treating coal to obtain a refined carbonaceous material | |
US4176228A (en) | Potassium-magnesium-calcium glycyrrhizin | |
US2419211A (en) | Tall oil treatment | |
GB490099A (en) | Improved method of producing pure alumina | |
US1994070A (en) | Process for treating raw phosphates | |
US1806973A (en) | Irvin w | |
US2890231A (en) | Alkaline extraction of chemical products from bark | |
US4256628A (en) | Sulfur-free acidulation of tall oil soap | |
US1651617A (en) | Extracting of guaiacol | |
US2162323A (en) | Process for the recovery of beryllium compounds | |
US2157260A (en) | Process for the preparation of potassium nitrate | |
US1303176A (en) | Ligno tanning material and process of producing the same from | |
US2097743A (en) | Method for the recovery of terpenes from mixtures containing the same | |
US2033149A (en) | Process for the recovery of potassium salts from minerals | |
US1492717A (en) | Method of concentrating aqueous solutions of volatile substances | |
US1851872A (en) | Method for obtaining theobromine | |
US2122997A (en) | Method of recovering zinc sulphate dihydrate | |
US1394150A (en) | Production of m-nitro-p-cresol | |
DE933866C (en) | Process for the production of melamine from cyanamide | |
US2996495A (en) | Wood extraction |