UA88771C2 - Proteasome inhibitors and methods of using the same (variants) - Google Patents
Proteasome inhibitors and methods of using the same (variants)Info
- Publication number
- UA88771C2 UA88771C2 UAA200602694A UAA200602694A UA88771C2 UA 88771 C2 UA88771 C2 UA 88771C2 UA A200602694 A UAA200602694 A UA A200602694A UA A200602694 A UAA200602694 A UA A200602694A UA 88771 C2 UA88771 C2 UA 88771C2
- Authority
- UA
- Ukraine
- Prior art keywords
- methods
- variants
- same
- proteasome inhibitors
- compositions
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49576403P | 2003-08-14 | 2003-08-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
UA88771C2 true UA88771C2 (en) | 2009-11-25 |
Family
ID=37426112
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA200602694A UA88771C2 (en) | 2003-08-14 | 2004-08-13 | Proteasome inhibitors and methods of using the same (variants) |
Country Status (7)
Country | Link |
---|---|
CN (1) | CN1867572B (en) |
AR (2) | AR045381A1 (en) |
MY (1) | MY162518A (en) |
PE (1) | PE20050360A1 (en) |
TW (1) | TWI345465B (en) |
UA (1) | UA88771C2 (en) |
ZA (1) | ZA200601293B (en) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102961387B (en) * | 2007-08-06 | 2016-04-27 | 米伦纽姆医药公司 | Proteasome inhibitor |
CN105837608B (en) * | 2007-08-06 | 2018-06-08 | 米伦纽姆医药公司 | Proteasome inhibitor and combinations thereof and purposes |
WO2009020448A1 (en) * | 2007-08-06 | 2009-02-12 | Millennium Pharmaceuticals, Inc. | Proteasome inhibitors |
EP2730579A1 (en) * | 2008-06-17 | 2014-05-14 | Millennium Pharmaceuticals, Inc. | Boronate ester compounds and pharmaceutical compositions thereof |
CN101638414B (en) * | 2008-07-30 | 2014-01-08 | 江苏先声药物研究有限公司 | Peptidyl boronic acid, ester compound thereof, preparation method of peptidyl boronic acid and ester compound thereof, and use of peptidyl boronic acid and ester compound thereof |
AR075090A1 (en) * | 2008-09-29 | 2011-03-09 | Millennium Pharm Inc | ACID DERIVATIVES 1-AMINO-2-CYCLLOBUTILETILBORONICO PROTEOSOMA INHIBITORS, USEFUL AS ANTI-BANKER AGENTS, AND PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND THEM. |
CN101747354B (en) * | 2008-12-04 | 2014-08-13 | 江苏先声药物研究有限公司 | Dipeptide boronic acids consisting of beta amino acids, ester compounds and preparation methods and uses thereof |
AU2010341530B2 (en) * | 2009-12-22 | 2016-03-10 | Cephalon, Inc. | Proteasome inhibitors and processes for their preparation, purification and use |
JP5933523B2 (en) * | 2010-03-31 | 2016-06-08 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | Derivatives of 1-amino-2-cyclopropylethylboronic acid |
BR112017006622A2 (en) * | 2014-10-01 | 2018-07-03 | Merck Patent Gmbh | boronic acid derivatives |
CN106588965A (en) * | 2015-10-15 | 2017-04-26 | 北京大学 | Urea peptidomimetic boric acid compound as well as pharmaceutical composition, preparation method and application thereof |
WO2017198194A1 (en) * | 2016-05-19 | 2017-11-23 | 成都奥璟生物科技有限公司 | Boronic acid and borate ester compound and applications thereof |
JP7071400B6 (en) * | 2017-01-18 | 2022-06-07 | プリンシピア バイオファーマ インコーポレイテッド | Immune proteasome inhibitor |
WO2018133661A1 (en) * | 2017-01-23 | 2018-07-26 | 成都奥璟生物科技有限公司 | Novel boric acid derivative and pharmaceutical composition using same |
CN114437119A (en) * | 2020-10-30 | 2022-05-06 | 苏州开拓药业股份有限公司 | C-Myc protein inhibitor and preparation method and application thereof |
-
2004
- 2004-08-13 MY MYPI20043299A patent/MY162518A/en unknown
- 2004-08-13 CN CN2004800301520A patent/CN1867572B/en active Active
- 2004-08-13 PE PE2004000784A patent/PE20050360A1/en active IP Right Grant
- 2004-08-13 TW TW93124291A patent/TWI345465B/en active
- 2004-08-13 UA UAA200602694A patent/UA88771C2/en unknown
- 2004-08-17 AR ARP040102935 patent/AR045381A1/en not_active Application Discontinuation
-
2006
- 2006-02-13 ZA ZA200601293A patent/ZA200601293B/en unknown
-
2014
- 2014-03-11 AR ARP140100859A patent/AR095249A2/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
TWI345465B (en) | 2011-07-21 |
CN1867572B (en) | 2012-03-28 |
ZA200601293B (en) | 2009-09-30 |
TW200529810A (en) | 2005-09-16 |
AR095249A2 (en) | 2015-09-30 |
PE20050360A1 (en) | 2005-06-10 |
CN1867572A (en) | 2006-11-22 |
AR045381A1 (en) | 2005-10-26 |
MY162518A (en) | 2017-06-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1091839A1 (en) | Proteasome inhibitors and methods of using the same | |
HK1089153A1 (en) | Proteasome inhibitors and methods of using the same | |
TWI367886B (en) | Proteasome inhibitors and methods of using the same | |
PH12014500053A1 (en) | Proteasome inhibitors | |
PH12015501191A1 (en) | Boronate ester compounds and pharmaceutical compositions thereof | |
MXPA05005223A (en) | Diaminotriazoles useful as inhibitors of protein kinases. | |
UA104849C2 (en) | 4-pyrazolyl-n-arylpyrimidin-2-amines and 4-pyrazolyl-n-heteroarylpyrimidin-2-amines as inhibitors of janus kinases | |
UA88771C2 (en) | Proteasome inhibitors and methods of using the same (variants) | |
MXPA05013226A (en) | Substituted piperidine carbamates for use as inhibitors of hormone sensitive lipase. | |
TW200603791A (en) | Compounds and compositions as cathepsin S inhibitors | |
MY180594A (en) | Proteasome inhibitors |