UA115320C2 - Інгібітори кінази - Google Patents
Інгібітори кіназиInfo
- Publication number
- UA115320C2 UA115320C2 UAA201406293A UAA201406293A UA115320C2 UA 115320 C2 UA115320 C2 UA 115320C2 UA A201406293 A UAA201406293 A UA A201406293A UA A201406293 A UAA201406293 A UA A201406293A UA 115320 C2 UA115320 C2 UA 115320C2
- Authority
- UA
- Ukraine
- Prior art keywords
- kinase inhibitors
- formula
- inhibitors
- марк
- diseases
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/02—Formic acid
- C07C53/06—Salts thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
Сполука загальної формули (І) або її фармацевтично прийнятна сіль: EMBED ISISServer , (I) у якій R2, W, A, Y та R1 є такими, як визначено у описі. Зазначені сполуки є інгібіторами МАР-кінази р38, корисними як протизапальні агенти у лікуванні, серед іншого, хвороб дихальних шляхів.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11192871 | 2011-12-09 | ||
EP12187931 | 2012-10-10 | ||
PCT/EP2012/074446 WO2013083604A1 (en) | 2011-12-09 | 2012-12-05 | Kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
UA115320C2 true UA115320C2 (uk) | 2017-10-25 |
Family
ID=47471708
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA201406293A UA115320C2 (uk) | 2011-12-09 | 2012-12-05 | Інгібітори кінази |
Country Status (35)
Country | Link |
---|---|
US (5) | US8907094B2 (uk) |
EP (1) | EP2788349B1 (uk) |
JP (1) | JP6128449B2 (uk) |
KR (1) | KR101994381B1 (uk) |
CN (3) | CN105968110B (uk) |
AR (1) | AR089189A1 (uk) |
AU (1) | AU2012347350C1 (uk) |
BR (1) | BR112014013760A2 (uk) |
CA (1) | CA2858447C (uk) |
CL (1) | CL2014001486A1 (uk) |
CO (1) | CO6970602A2 (uk) |
CY (1) | CY1118340T1 (uk) |
DK (1) | DK2788349T3 (uk) |
EA (1) | EA025268B1 (uk) |
ES (1) | ES2612259T3 (uk) |
GE (1) | GEP201706735B (uk) |
HK (2) | HK1222647A1 (uk) |
HR (1) | HRP20161714T1 (uk) |
HU (1) | HUE029826T2 (uk) |
IL (1) | IL232958A (uk) |
LT (1) | LT2788349T (uk) |
ME (1) | ME02624B (uk) |
MX (1) | MX359200B (uk) |
MY (1) | MY170656A (uk) |
PE (1) | PE20141370A1 (uk) |
PH (1) | PH12014501277B1 (uk) |
PL (1) | PL2788349T3 (uk) |
PT (1) | PT2788349T (uk) |
RS (1) | RS55602B1 (uk) |
SG (1) | SG11201402985VA (uk) |
SI (1) | SI2788349T1 (uk) |
TW (1) | TWI618703B (uk) |
UA (1) | UA115320C2 (uk) |
WO (1) | WO2013083604A1 (uk) |
ZA (1) | ZA201404156B (uk) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG10201604656YA (en) | 2011-12-09 | 2016-07-28 | Chiesi Farma Spa | Kinase inhibitors |
CN103987708B (zh) * | 2011-12-09 | 2016-06-22 | 奇斯药制品公司 | 4-羟基-1,2,3,4-四氢萘-1-基脲的衍生物及其在呼吸道疾病治疗中的用途 |
UA115320C2 (uk) * | 2011-12-09 | 2017-10-25 | К'Єзі Фармачеутічі С.П.А. | Інгібітори кінази |
GB201214750D0 (en) | 2012-08-17 | 2012-10-03 | Respivert Ltd | Compounds |
WO2014033449A1 (en) | 2012-08-29 | 2014-03-06 | Respivert Limited | Kinase inhibitors |
US20150210722A1 (en) | 2012-08-29 | 2015-07-30 | Respivert Limited | Kinase inhibitors |
EP2890695A2 (en) | 2012-08-29 | 2015-07-08 | Respivert Limited | Kinase inhibitors |
US9732063B2 (en) | 2012-11-16 | 2017-08-15 | Respivert Limited | Kinase inhibitors |
US20160016934A1 (en) | 2013-03-14 | 2016-01-21 | Respivert Limited | Kinase inhibitors |
CA2907663A1 (en) | 2013-04-02 | 2014-10-09 | Respivert Limited | Urea derivatives useful as kinase inhibitors |
US9771353B2 (en) | 2013-04-02 | 2017-09-26 | Topivert Pharma Limited | Kinase inhibitors based upon N-alkyl pyrazoles |
EP3004098B1 (en) * | 2013-06-06 | 2017-08-09 | Chiesi Farmaceutici S.p.A. | Kinase inhibitors |
EP3004097B1 (en) | 2013-06-06 | 2018-01-17 | Chiesi Farmaceutici S.p.A. | Kinase inhibitors |
CA2914457A1 (en) | 2013-06-06 | 2014-12-11 | Chiesi Farmaceutici S.P.A. | Kinase inhibitors |
EP2818471A1 (en) * | 2013-06-27 | 2014-12-31 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Nitrogen bicyclic compounds as inhibitors for Scyl1 and Grk5 |
JP6514703B2 (ja) | 2013-12-20 | 2019-05-15 | トピバート ファーマ リミテッド | キナーゼインヒビターとして有用な尿素誘導体 |
DK3105222T3 (en) | 2014-02-14 | 2018-07-23 | Respivert Ltd | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTI-INFLAMMATORY COMPOUNDS |
MA40775A (fr) | 2014-10-01 | 2017-08-08 | Respivert Ltd | Dérivé d'acide 4-(4-(4-phényluréido-naphtalén -1-yl) oxy-pyridin-2-yl) amino-benzoïque utilisé en tant qu'inhibiteur de la kinase p38 |
US10206949B2 (en) | 2015-09-21 | 2019-02-19 | Ofer Agam | Composition that relieves heartburn, GERD and hangovers |
AR107164A1 (es) | 2015-12-23 | 2018-03-28 | Chiesi Farm Spa | INHIBIDORES DE QUINASA p38 |
AR107163A1 (es) | 2015-12-23 | 2018-03-28 | Chiesi Farm Spa | Inhibidores de quinasa |
EP3394059B1 (en) | 2015-12-23 | 2020-11-25 | Chiesi Farmaceutici S.p.A. | 1-(3-tert-butyl-phenyl)-3-(4-([1,2,4]triazolo[4,3-a]pyridin-6-yloxy)-1,2,3,4-tetrahydro- naphthalen-1-yl)-urea derivatives and their use as p38 mapk inhibitors |
WO2017174995A1 (en) | 2016-04-06 | 2017-10-12 | Respivert Limited | Kinase inhibitors |
US10364245B2 (en) | 2017-06-07 | 2019-07-30 | Chiesi Farmaceutici S.P.A. | Kinase inhibitors |
MX2020003594A (es) | 2017-10-05 | 2021-04-07 | Fulcrum Therapeutics Inc | Inhibidores de la quinasa p38 que reducen la expresión de dux4 y de los genes corriente abajo para el tratamiento de fshd. |
US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
CN108424372B (zh) * | 2018-05-11 | 2021-08-10 | 浙江华贝药业有限责任公司 | 2,2,2-三氟-n-[(s)-4-羰基四氢萘-1-基]-乙酰胺的纯化工艺 |
CN108707086B (zh) * | 2018-05-15 | 2021-08-10 | 浙江华贝药业有限责任公司 | 一种(1s,4s)-n-(4-羟基四氢萘-1-基)叔丁氧基碳酰胺的纯化工艺 |
AR116628A1 (es) | 2018-10-18 | 2021-05-26 | Syngenta Crop Protection Ag | Compuestos microbiocidas |
CA3169012A1 (en) | 2020-03-05 | 2021-09-10 | Syngenta Crop Protection Ag | Fungicidal compositions |
CN112174870B (zh) * | 2020-10-12 | 2023-07-21 | 蔡霈 | (r)-1-烷烃酰基-2-取代吡咯烷-2-甲酰胺的制备方法及其药用用途 |
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JP2006517580A (ja) | 2003-02-14 | 2006-07-27 | ファイザー・プロダクツ・インク | 抗炎症化合物としてのトリアゾロピリジン |
SE0302487D0 (sv) | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
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EP1609789A1 (en) | 2004-06-23 | 2005-12-28 | Eli Lilly And Company | Ureido-pyrazole derivatives and their use as kinase inhibitors |
PL1761520T3 (pl) | 2004-06-23 | 2008-12-31 | Lilly Co Eli | Inhibitory kinazy |
GB0418015D0 (en) * | 2004-08-12 | 2004-09-15 | Pfizer Ltd | New compounds |
PT1778686E (pt) | 2004-08-12 | 2008-12-26 | Pfizer | Derivados de triazolopiridinilsufanilo como inibidores da p38 map-cinase |
EP1781655A2 (en) | 2004-08-18 | 2007-05-09 | Pharmacia & Upjohn Company LLC | Triazolopyridine compounds useful for the treatment of inflammation |
GB0502258D0 (en) | 2005-02-03 | 2005-03-09 | Argenta Discovery Ltd | Compounds and their use |
CA2610509A1 (en) | 2005-06-03 | 2006-12-14 | Bayer Healthcare Ag | 1-methyl-1h-pyrazole-4-carboxamides useful as cancer chemotherapeutic agents |
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EP2308866A1 (de) | 2009-10-09 | 2011-04-13 | Bayer CropScience AG | Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide |
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WO2011124930A1 (en) * | 2010-04-08 | 2011-10-13 | Respivert Limited | P38 map kinase inhibitors |
GB201009731D0 (en) * | 2010-06-10 | 2010-07-21 | Pulmagen Therapeutics Inflamma | Kinase inhibitors |
SG10201604656YA (en) | 2011-12-09 | 2016-07-28 | Chiesi Farma Spa | Kinase inhibitors |
UA115320C2 (uk) | 2011-12-09 | 2017-10-25 | К'Єзі Фармачеутічі С.П.А. | Інгібітори кінази |
CN103987708B (zh) | 2011-12-09 | 2016-06-22 | 奇斯药制品公司 | 4-羟基-1,2,3,4-四氢萘-1-基脲的衍生物及其在呼吸道疾病治疗中的用途 |
EP3004097B1 (en) | 2013-06-06 | 2018-01-17 | Chiesi Farmaceutici S.p.A. | Kinase inhibitors |
CA2914457A1 (en) | 2013-06-06 | 2014-12-11 | Chiesi Farmaceutici S.P.A. | Kinase inhibitors |
EP3004098B1 (en) | 2013-06-06 | 2017-08-09 | Chiesi Farmaceutici S.p.A. | Kinase inhibitors |
-
2012
- 2012-12-05 UA UAA201406293A patent/UA115320C2/uk unknown
- 2012-12-05 BR BR112014013760A patent/BR112014013760A2/pt not_active Application Discontinuation
- 2012-12-05 SG SG11201402985VA patent/SG11201402985VA/en unknown
- 2012-12-05 CN CN201610333320.8A patent/CN105968110B/zh not_active Expired - Fee Related
- 2012-12-05 AU AU2012347350A patent/AU2012347350C1/en not_active Ceased
- 2012-12-05 PT PT128091402T patent/PT2788349T/pt unknown
- 2012-12-05 CN CN201510853733.4A patent/CN105503861B/zh not_active Expired - Fee Related
- 2012-12-05 KR KR1020147018237A patent/KR101994381B1/ko active IP Right Grant
- 2012-12-05 EP EP12809140.2A patent/EP2788349B1/en active Active
- 2012-12-05 EA EA201490949A patent/EA025268B1/ru unknown
- 2012-12-05 SI SI201230806A patent/SI2788349T1/sl unknown
- 2012-12-05 DK DK12809140.2T patent/DK2788349T3/en active
- 2012-12-05 CA CA2858447A patent/CA2858447C/en not_active Expired - Fee Related
- 2012-12-05 HU HUE12809140A patent/HUE029826T2/en unknown
- 2012-12-05 PE PE2014000923A patent/PE20141370A1/es active IP Right Grant
- 2012-12-05 LT LTEP12809140.2T patent/LT2788349T/lt unknown
- 2012-12-05 CN CN201280066480.0A patent/CN104039787B/zh not_active Expired - Fee Related
- 2012-12-05 JP JP2014545229A patent/JP6128449B2/ja not_active Expired - Fee Related
- 2012-12-05 RS RS20170046A patent/RS55602B1/sr unknown
- 2012-12-05 GE GEAP201213495A patent/GEP201706735B/en unknown
- 2012-12-05 ME MEP-2016-279A patent/ME02624B/me unknown
- 2012-12-05 MY MYPI2014001662A patent/MY170656A/en unknown
- 2012-12-05 ES ES12809140T patent/ES2612259T3/es active Active
- 2012-12-05 MX MX2014006724A patent/MX359200B/es active IP Right Grant
- 2012-12-05 WO PCT/EP2012/074446 patent/WO2013083604A1/en active Application Filing
- 2012-12-05 PL PL12809140T patent/PL2788349T3/pl unknown
- 2012-12-07 AR ARP120104598A patent/AR089189A1/es not_active Application Discontinuation
- 2012-12-07 US US13/708,324 patent/US8907094B2/en not_active Expired - Fee Related
- 2012-12-07 TW TW101146036A patent/TWI618703B/zh not_active IP Right Cessation
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2014
- 2014-06-05 IL IL232958A patent/IL232958A/en active IP Right Grant
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- 2014-06-06 CL CL2014001486A patent/CL2014001486A1/es unknown
- 2014-06-06 ZA ZA2014/04156A patent/ZA201404156B/en unknown
- 2014-07-14 US US14/330,145 patent/US9145413B2/en not_active Expired - Fee Related
- 2014-10-14 US US14/513,663 patent/US9139584B2/en not_active Expired - Fee Related
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2015
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- 2015-08-06 US US14/819,722 patent/US9315503B2/en active Active
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2016
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