SG174066A1 - Leptomycin derivatives - Google Patents

Leptomycin derivatives Download PDF

Info

Publication number: SG174066A1
Authority: SG; Singapore
Prior art keywords: leptomycin; alk; anyone; derivative; cell binding
Prior art date: 2006-06-09

Application number

SG2011057809A

Other languages

English (en)

Inventor

Herve Bouchard

Alain Commercon

Ravi V J Chari

Original Assignee

Sanofi Aventis

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-06-09

Filing date

2007-05-23

Publication date

2011-09-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37311892&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG174066(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2007-05-23 Application filed by Sanofi Aventis filed Critical Sanofi Aventis

2011-09-29 Publication of SG174066A1 publication Critical patent/SG174066A1/en

Links

YACHGFWEQXFSBS-RJXCBBHPSA-N leptomycin Chemical class OC(=O)/C=C(C)/C[C@H](C)[C@@H](O)[C@H](C)C(=O)[C@H](C)/C=C(\C)/C=C/C[C@@H](C)\C=C(/CC)\C=C\[C@@H]1OC(=O)C=C[C@@H]1C YACHGFWEQXFSBS-RJXCBBHPSA-N 0.000 title claims abstract 21
BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims abstract description 11
UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 claims abstract description 11
239000003153 chemical reaction reagent Substances 0.000 claims abstract description 11
239000011230 binding agent Substances 0.000 claims description 61
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150000001875 compounds Chemical class 0.000 claims description 45
238000000034 method Methods 0.000 claims description 32
239000003814 drug Substances 0.000 claims description 24
206010028980 Neoplasm Diseases 0.000 claims description 23
-1 2-mercaptoethyl Chemical group 0.000 claims description 20
201000011510 cancer Diseases 0.000 claims description 19
150000003839 salts Chemical class 0.000 claims description 19
239000002253 acid Substances 0.000 claims description 17
125000000217 alkyl group Chemical group 0.000 claims description 17
238000002360 preparation method Methods 0.000 claims description 15
150000003573 thiols Chemical class 0.000 claims description 15
239000003795 chemical substances by application Substances 0.000 claims description 11
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125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 7
239000012634 fragment Substances 0.000 claims description 5
LCVDHXURABCEDA-UHFFFAOYSA-N 2-(methyldisulfanyl)ethanamine Chemical compound CSSCCN LCVDHXURABCEDA-UHFFFAOYSA-N 0.000 claims description 4
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 4
125000000753 cycloalkyl group Chemical group 0.000 claims description 4
UFULAYFCSOUIOV-UHFFFAOYSA-N cysteamine Chemical compound NCCS UFULAYFCSOUIOV-UHFFFAOYSA-N 0.000 claims description 4
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125000000623 heterocyclic group Chemical group 0.000 claims description 3
IHVODYOQUSEYJJ-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 6-[[4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexanecarbonyl]amino]hexanoate Chemical compound O=C1CCC(=O)N1OC(=O)CCCCCNC(=O)C(CC1)CCC1CN1C(=O)C=CC1=O IHVODYOQUSEYJJ-UHFFFAOYSA-N 0.000 claims description 2
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Classifications

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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6863—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from stomach or intestines cancer cell
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Immunology (AREA)
Cell Biology (AREA)
Oncology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicinal Preparation (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pyrane Compounds (AREA)

SG2011057809A 2006-06-09 2007-05-23 Leptomycin derivatives SG174066A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP06290948A EP1864682A1 (en)	2006-06-09	2006-06-09	Leptomycin derivatives

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SG174066A1 true SG174066A1 (en)	2011-09-29

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US (2)	US7816543B2 (es)
EP (3)	EP1864682A1 (es)
JP (1)	JP5162581B2 (es)
KR (1)	KR20090018103A (es)
CN (2)	CN101466409B (es)
AR (1)	AR063668A1 (es)
AU (1)	AU2007258896B2 (es)
BR (1)	BRPI0712899A2 (es)
CA (1)	CA2654322A1 (es)
CL (1)	CL2007001648A1 (es)
CR (1)	CR10459A (es)
EA (1)	EA017345B1 (es)
EC (1)	ECSP088936A (es)
GT (1)	GT200800277A (es)
HK (1)	HK1134240A1 (es)
HN (1)	HN2008001788A (es)
IL (1)	IL195419A0 (es)
MA (1)	MA30689B1 (es)
ME (1)	MEP88208A (es)
MX (1)	MX2008015728A (es)
MY (1)	MY148231A (es)
NO (1)	NO20085127L (es)
NZ (1)	NZ572947A (es)
SG (2)	SG174067A1 (es)
TN (1)	TNSN08463A1 (es)
TW (1)	TWI411609B (es)
UA (1)	UA95959C2 (es)
WO (1)	WO2007144709A2 (es)
ZA (1)	ZA200810015B (es)

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FR2963007B1 (fr)	2010-07-26	2013-04-05	Sanofi Aventis	Derives anticancereux, leur preparation et leur application therapeutique
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JOP20190254A1 (ar)	2017-04-27	2019-10-27	Pharma Mar Sa	مركبات مضادة للأورام
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EA010570B1 (ru)	2002-11-07	2008-10-30	Иммьюноджен, Инк.	Антитело к cd33 и способы его применения
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EP1864682A1 (en) *	2006-06-09	2007-12-12	Sanofi-Aventis	Leptomycin derivatives

2006
- 2006-06-09 EP EP06290948A patent/EP1864682A1/en not_active Withdrawn
2007
- 2007-05-23 MX MX2008015728A patent/MX2008015728A/es active IP Right Grant
- 2007-05-23 ME MEP-882/08A patent/MEP88208A/xx unknown
- 2007-05-23 CA CA002654322A patent/CA2654322A1/en not_active Abandoned
- 2007-05-23 NZ NZ572947A patent/NZ572947A/en not_active IP Right Cessation
- 2007-05-23 AU AU2007258896A patent/AU2007258896B2/en not_active Ceased
- 2007-05-23 EA EA200870615A patent/EA017345B1/ru not_active IP Right Cessation
- 2007-05-23 EP EP07734635A patent/EP2032172B1/en active Active
- 2007-05-23 BR BRPI0712899-1A patent/BRPI0712899A2/pt not_active IP Right Cessation
- 2007-05-23 SG SG2011057817A patent/SG174067A1/en unknown
- 2007-05-23 JP JP2009513781A patent/JP5162581B2/ja not_active Expired - Fee Related
- 2007-05-23 MY MYPI20084971A patent/MY148231A/en unknown
- 2007-05-23 SG SG2011057809A patent/SG174066A1/en unknown
- 2007-05-23 UA UAA200900137A patent/UA95959C2/ru unknown
- 2007-05-23 CN CN2007800215355A patent/CN101466409B/zh not_active Expired - Fee Related
- 2007-05-23 EP EP11188684A patent/EP2540320A1/en not_active Withdrawn
- 2007-05-23 CN CN2012102164755A patent/CN102731611A/zh active Pending
- 2007-05-23 WO PCT/IB2007/001328 patent/WO2007144709A2/en active Search and Examination
- 2007-05-23 KR KR1020087029913A patent/KR20090018103A/ko active IP Right Grant
- 2007-05-24 TW TW096118553A patent/TWI411609B/zh not_active IP Right Cessation
- 2007-06-07 CL CL2007001648A patent/CL2007001648A1/es unknown
- 2007-06-08 AR ARP070102511A patent/AR063668A1/es not_active Application Discontinuation
2008
- 2008-11-17 TN TNP2008000463A patent/TNSN08463A1/en unknown
- 2008-11-20 IL IL195419A patent/IL195419A0/en unknown
- 2008-11-24 US US12/276,568 patent/US7816543B2/en not_active Expired - Fee Related
- 2008-11-25 ZA ZA2008/10015A patent/ZA200810015B/en unknown
- 2008-11-25 CR CR10459A patent/CR10459A/es not_active Application Discontinuation
- 2008-12-03 EC EC2008008936A patent/ECSP088936A/es unknown
- 2008-12-08 GT GT200800277A patent/GT200800277A/es unknown
- 2008-12-09 HN HN2008001788A patent/HN2008001788A/es unknown
- 2008-12-09 NO NO20085127A patent/NO20085127L/no not_active Application Discontinuation
- 2008-12-26 MA MA31515A patent/MA30689B1/fr unknown
2009
- 2009-12-10 HK HK09111635.9A patent/HK1134240A1/xx not_active IP Right Cessation
2010
- 2010-09-14 US US12/881,792 patent/US20110002947A1/en not_active Abandoned

Also Published As

Publication number	Publication date
HK1134240A1 (en)	2010-04-23
CN101466409B (zh)	2012-11-21
GT200800277A (es)	2009-06-16
CA2654322A1 (en)	2007-12-21
AU2007258896B2 (en)	2013-01-24
EA200870615A1 (ru)	2009-04-28
US20090182038A1 (en)	2009-07-16
MX2008015728A (es)	2009-01-09
MY148231A (en)	2013-03-29
JP2009539820A (ja)	2009-11-19
CL2007001648A1 (es)	2008-01-18
MA30689B1 (fr)	2009-09-01
EP2540320A1 (en)	2013-01-02
BRPI0712899A2 (pt)	2013-01-08
US7816543B2 (en)	2010-10-19
CR10459A (es)	2009-01-09
US20110002947A1 (en)	2011-01-06
AU2007258896A1 (en)	2007-12-21
TWI411609B (zh)	2013-10-11
AR063668A1 (es)	2009-02-11
UA95959C2 (en)	2011-09-26
HN2008001788A (es)	2012-08-27
WO2007144709A3 (en)	2008-06-12
EA017345B1 (ru)	2012-11-30
KR20090018103A (ko)	2009-02-19
JP5162581B2 (ja)	2013-03-13
SG174067A1 (en)	2011-09-29
IL195419A0 (en)	2009-08-03
EP2032172B1 (en)	2012-06-06
CN102731611A (zh)	2012-10-17
MEP88208A (en)	2011-12-20
TW200812996A (en)	2008-03-16
EP2032172A2 (en)	2009-03-11
TNSN08463A1 (en)	2010-04-14
WO2007144709A2 (en)	2007-12-21
ZA200810015B (en)	2010-02-24
ECSP088936A (es)	2009-01-30
NZ572947A (en)	2011-12-22
EP1864682A1 (en)	2007-12-12
NO20085127L (no)	2009-01-08
CN101466409A (zh)	2009-06-24

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US7816543B2 (en)	2010-10-19	Leptomycin derivatives
US20180043013A1 (en)	2018-02-15	Cytotoxic agents comprising new maytansinoids (dm4)
EP1651162B1 (en)	2015-10-21	Improved cytotoxic agents comprising new maytansinoids
EP1832577A1 (en)	2007-09-12	Improved prodrugs of CC-1065 analogs
US20110008373A1 (en)	2011-01-13	Prodrugs of cc-1065 analogs