SG11202009787VA - Modified mitochondria and use thereof - Google Patents
Modified mitochondria and use thereofInfo
- Publication number
- SG11202009787VA SG11202009787VA SG11202009787VA SG11202009787VA SG11202009787VA SG 11202009787V A SG11202009787V A SG 11202009787VA SG 11202009787V A SG11202009787V A SG 11202009787VA SG 11202009787V A SG11202009787V A SG 11202009787VA SG 11202009787V A SG11202009787V A SG 11202009787VA
- Authority
- SG
- Singapore
- Prior art keywords
- modified mitochondria
- mitochondria
- modified
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4746—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used p53
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0006—Modification of the membrane of cells, e.g. cell decoration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
- C07K16/2854—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72 against selectins, e.g. CD62
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3053—Skin, nerves, brain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6467—Granzymes, e.g. granzyme A (3.4.21.78); granzyme B (3.4.21.79)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
- C12Y301/03016—Phosphoprotein phosphatase (3.1.3.16), i.e. calcineurin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
- C12Y301/03048—Protein-tyrosine-phosphatase (3.1.3.48)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
- C12Y301/03067—Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase (3.1.3.67)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21079—Granzyme B (3.4.21.79)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
- A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/80—Immunoglobulins specific features remaining in the (producing) cell, i.e. intracellular antibodies or intrabodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/07—Fusion polypeptide containing a localisation/targetting motif containing a mitochondrial localisation signal
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/95—Fusion polypeptide containing a motif/fusion for degradation (ubiquitin fusions, PEST sequence)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Mycology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20180048486 | 2018-04-26 | ||
PCT/KR2019/005020 WO2019209051A1 (en) | 2018-04-26 | 2019-04-25 | Modified mitochondria and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202009787VA true SG11202009787VA (en) | 2020-11-27 |
Family
ID=68295600
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202009787VA SG11202009787VA (en) | 2018-04-26 | 2019-04-25 | Modified mitochondria and use thereof |
Country Status (10)
Country | Link |
---|---|
US (1) | US20210238249A1 (en) |
EP (1) | EP3786177A4 (en) |
JP (2) | JP2021521819A (en) |
KR (3) | KR102126199B1 (en) |
CN (1) | CN112020553A (en) |
AU (1) | AU2019257834A1 (en) |
BR (1) | BR112020021826A2 (en) |
CA (1) | CA3097108A1 (en) |
SG (1) | SG11202009787VA (en) |
WO (1) | WO2019209051A1 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020163856A1 (en) * | 2019-02-10 | 2020-08-13 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Modified mitochondrion and methods of use thereof |
KR102273163B1 (en) | 2020-09-10 | 2021-07-05 | 주식회사 파이안바이오테크놀로지 | Method for obtaining platelet-derived mitochondria and use thereof |
KR102290596B1 (en) * | 2020-09-10 | 2021-08-19 | 주식회사 파이안바이오테크놀로지 | Composition for injection comprising isolated mitochondria and use thereof |
EP4233882A4 (en) | 2020-10-22 | 2023-11-15 | Paean Biotechnology Inc. | Mitochondria comprising anticancer drug and use thereof |
KR20230116844A (en) * | 2020-11-30 | 2023-08-04 | 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 | Engineered Cells Functionalized with Immune Checkpoint Molecules and Their Uses |
CN113122497B (en) * | 2021-04-26 | 2023-08-11 | 重庆理工大学 | Engineered mitochondria and method of making same |
CN117979980A (en) * | 2021-07-23 | 2024-05-03 | 车医科学大学校产学协力团 | Pharmaceutical composition for preventing or treating aclar Xie Manzeng syndrome comprising isolated mitochondria as active ingredient |
KR102671551B1 (en) * | 2022-03-11 | 2024-06-03 | 주식회사 파이안바이오테크놀로지 | Modified mitochondria comprising prodrug converting enzyme and use thereof |
WO2023191495A1 (en) | 2022-03-29 | 2023-10-05 | 주식회사 파이안바이오테크놀로지 | Frozen and freeze-dried mitochondria and use thereof |
CN115779097B (en) * | 2022-11-09 | 2024-01-30 | 四川大学 | Tumor antigen delivery system based on engineering mitochondria and application |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10107677A1 (en) | 2001-02-19 | 2002-09-05 | Ipk Inst Fuer Pflanzengenetik | Process for the creation and transformation of mitochondrial conglomerates |
DE10211063A1 (en) * | 2002-03-13 | 2003-10-09 | Axaron Bioscience Ag | New methods for the detection and analysis of protein interactions in vivo |
JP2004041067A (en) | 2002-07-11 | 2004-02-12 | Japan Science & Technology Corp | Method for transporting protein to mitochondria |
US7271001B2 (en) * | 2004-12-10 | 2007-09-18 | The Research Foundation Of State University Of New York | Method for mitochondrial targeting of p53 |
JP2006238831A (en) | 2005-03-04 | 2006-09-14 | Iwate Univ | Method for modifying function of mitochondria |
US8278428B2 (en) * | 2007-02-16 | 2012-10-02 | John Guy | Mitochondrial nucleic acid delivery systems |
US20130101664A1 (en) * | 2011-08-18 | 2013-04-25 | Donald W. Kufe | Muc1 ligand traps for use in treating cancers |
US9540421B2 (en) * | 2012-08-31 | 2017-01-10 | University-Industry Cooperation Group Of Kyung Hee University | Mitochondria targeting peptide |
CN104630149B (en) | 2013-11-08 | 2018-08-21 | 中国科学院广州生物医药与健康研究院 | Xenogenic mitochondrial imported into the method in mammalian cell |
EP2992892A1 (en) | 2014-09-05 | 2016-03-09 | Universität zu Köln | Fusion protein for use in the treatment of mitochondrial diseases |
CN104357470B (en) * | 2014-11-14 | 2017-02-15 | 四川大学华西第二医院 | HtrA2 fusion gene and application thereof |
EP3735976A3 (en) * | 2016-01-15 | 2021-01-27 | The Children's Medical Center Corporation | Therapeutic use of mitochondria and combined mitochondrial agents |
WO2017221271A1 (en) * | 2016-06-22 | 2017-12-28 | Indian Institute Of Technology Delhi | Organelle-targeting nanocarrier |
US11491234B2 (en) * | 2017-11-09 | 2022-11-08 | University Of Washington | Mitochondrial localization signals in human tafazzin and uses thereof |
-
2019
- 2019-04-25 EP EP19791949.1A patent/EP3786177A4/en active Pending
- 2019-04-25 CN CN201980028175.4A patent/CN112020553A/en active Pending
- 2019-04-25 CA CA3097108A patent/CA3097108A1/en active Pending
- 2019-04-25 SG SG11202009787VA patent/SG11202009787VA/en unknown
- 2019-04-25 BR BR112020021826-0A patent/BR112020021826A2/en not_active Application Discontinuation
- 2019-04-25 AU AU2019257834A patent/AU2019257834A1/en active Pending
- 2019-04-25 US US17/049,301 patent/US20210238249A1/en active Pending
- 2019-04-25 JP JP2020559381A patent/JP2021521819A/en active Pending
- 2019-04-25 KR KR1020190048279A patent/KR102126199B1/en active IP Right Grant
- 2019-04-25 WO PCT/KR2019/005020 patent/WO2019209051A1/en active Application Filing
-
2020
- 2020-06-17 KR KR1020200073339A patent/KR102533834B1/en active IP Right Grant
-
2023
- 2023-04-28 JP JP2023074253A patent/JP2023099118A/en active Pending
- 2023-05-12 KR KR1020230061831A patent/KR20230074076A/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
KR102533834B1 (en) | 2023-05-19 |
KR20200077476A (en) | 2020-06-30 |
CA3097108A1 (en) | 2019-10-31 |
EP3786177A4 (en) | 2022-01-26 |
KR102126199B1 (en) | 2020-06-24 |
WO2019209051A1 (en) | 2019-10-31 |
CN112020553A (en) | 2020-12-01 |
BR112020021826A2 (en) | 2021-02-23 |
KR20190124656A (en) | 2019-11-05 |
AU2019257834A1 (en) | 2020-10-08 |
EP3786177A1 (en) | 2021-03-03 |
JP2021521819A (en) | 2021-08-30 |
KR20230074076A (en) | 2023-05-26 |
JP2023099118A (en) | 2023-07-11 |
US20210238249A1 (en) | 2021-08-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL268206A (en) | Bcma-targeting antibody and use thereof | |
SG11202009787VA (en) | Modified mitochondria and use thereof | |
ZA202001113B (en) | Anti-cd137 molecules and use thereof | |
ZA202006904B (en) | Anti-il-4r antibody and use thereof | |
SG11202100746WA (en) | Anti-tigit antibody and use thereof | |
DK3610005T3 (en) | PEPTIDLIGASE AND ITS USE | |
IL279458A (en) | Neoantigens and uses thereof | |
ZA202006066B (en) | Anti-hla-g antibodies and use thereof | |
IL264813B (en) | 2-oxo-imidazopyridines and their use | |
IL265834A (en) | Hla-restricted vgll1 peptides and use thereof | |
IL263242A (en) | Cytosol-penetrating antibody and use thereof | |
SG11202004877UA (en) | Sulfonamide compounds and use thereof | |
MA49905A (en) | POLYESTERAMINES AND POLYESTERQUATS | |
IL278881A (en) | Cannabinoids and uses thereof | |
SG11202008543RA (en) | Pyrrolidineamide derivatives and uses thereof | |
IL277749A (en) | Pladienolide compounds and their use | |
PT3796975T (en) | Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives | |
IL282527A (en) | Azaindazole-5 derivatives and their use | |
SG11202003585VA (en) | Anti-vista antibody and use thereof | |
IL280644A (en) | Magnesium-serinate compound and use thereof | |
ZA201906248B (en) | Anti-ceacam1 antibody and use thereof | |
IL265531A (en) | N 3 -cyclically substituted thienouraciles and use thereof | |
IL282526A (en) | Azaindazole-5 derivatives and their use | |
IL269836B (en) | Substituted n-arylethyl-2-aminoquinoline-4-carboxamides and use thereof | |
GB201803363D0 (en) | New materials and uses thereof |