SG10201906331TA - Methods for profiling and quantitating cell-free rna - Google Patents

Methods for profiling and quantitating cell-free rna

Info

Publication number
SG10201906331TA
SG10201906331TA SG10201906331TA SG10201906331TA SG10201906331TA SG 10201906331T A SG10201906331T A SG 10201906331TA SG 10201906331T A SG10201906331T A SG 10201906331TA SG 10201906331T A SG10201906331T A SG 10201906331TA SG 10201906331T A SG10201906331T A SG 10201906331TA
Authority
SG
Singapore
Prior art keywords
methods
rna
tissue
profiling
level
Prior art date
Application number
SG10201906331TA
Other languages
English (en)
Inventor
Lian Koh
Stephen Quake
Hei-Mun Christina Fan
Wenying Pan
Original Assignee
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leland Stanford Junior filed Critical Univ Leland Stanford Junior
Publication of SG10201906331TA publication Critical patent/SG10201906331TA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/40—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F18/00—Pattern recognition
    • G06F18/20—Analysing
    • G06F18/21—Design or setup of recognition systems or techniques; Extraction of features in feature space; Blind source separation
    • G06F18/213—Feature extraction, e.g. by transforming the feature space; Summarisation; Mappings, e.g. subspace methods
    • G06F18/2135—Feature extraction, e.g. by transforming the feature space; Summarisation; Mappings, e.g. subspace methods based on approximation criteria, e.g. principal component analysis

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Databases & Information Systems (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Public Health (AREA)
  • Bioethics (AREA)
  • Epidemiology (AREA)
  • Data Mining & Analysis (AREA)
  • Pathology (AREA)
  • Primary Health Care (AREA)
  • Artificial Intelligence (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Evolutionary Computation (AREA)
  • Software Systems (AREA)
  • Biomedical Technology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
SG10201906331TA 2012-01-27 2013-01-28 Methods for profiling and quantitating cell-free rna SG10201906331TA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261591642P 2012-01-27 2012-01-27

Publications (1)

Publication Number Publication Date
SG10201906331TA true SG10201906331TA (en) 2019-08-27

Family

ID=48874081

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201505515XA SG11201505515XA (en) 2012-01-27 2013-01-28 Methods for profiling and quantitating cell-free rna
SG10201906331TA SG10201906331TA (en) 2012-01-27 2013-01-28 Methods for profiling and quantitating cell-free rna

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG11201505515XA SG11201505515XA (en) 2012-01-27 2013-01-28 Methods for profiling and quantitating cell-free rna

Country Status (9)

Country Link
US (14) US20130252835A1 (fr)
EP (2) EP2807277A4 (fr)
JP (2) JP6320302B2 (fr)
CN (2) CN108359711A (fr)
AU (1) AU2013211850B8 (fr)
CA (1) CA2863035C (fr)
HK (1) HK1211624A1 (fr)
SG (2) SG11201505515XA (fr)
WO (1) WO2013113012A2 (fr)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8583380B2 (en) 2008-09-05 2013-11-12 Aueon, Inc. Methods for stratifying and annotating cancer drug treatment options
PT2496720T (pt) 2009-11-06 2020-10-12 Univ Leland Stanford Junior Diagnóstico não-invasivo de rejeição de enxertos em pacientes sujeitos a transplantes de órgãos
US9309556B2 (en) 2010-09-24 2016-04-12 The Board Of Trustees Of The Leland Stanford Junior University Direct capture, amplification and sequencing of target DNA using immobilized primers
US20160289762A1 (en) * 2012-01-27 2016-10-06 The Board Of Trustees Of The Leland Stanford Junior University Methods for profiliing and quantitating cell-free rna
EP2807277A4 (fr) 2012-01-27 2016-02-17 Univ Leland Stanford Junior Procédés de profilage et de quantification d'arn acellulaire
WO2015069900A1 (fr) * 2013-11-06 2015-05-14 The Board Of Trustees Of The Leland Stanford Junior University Méthode pour profiler et quantifier un arn acellulaire
US10689652B2 (en) 2013-10-02 2020-06-23 The Regents Of The University Of California Methods for immortalization of epithelial cells
WO2015069933A1 (fr) * 2013-11-06 2015-05-14 The Board Of Trustees Of The Leland Stanford Junior University Adn acellulaire circulant pour le diagnostic du rejet de greffe
EP4130350A1 (fr) 2013-11-07 2023-02-08 The Board of Trustees of the Leland Stanford Junior University Acides nucléiques acellulaires pour l'analyse du microbiome humain et ses composants
CN117402950A (zh) 2014-07-25 2024-01-16 华盛顿大学 确定导致无细胞dna的产生的组织和/或细胞类型的方法以及使用其鉴定疾病或紊乱的方法
KR20170083563A (ko) 2014-11-14 2017-07-18 리퀴드 제노믹스, 아이엔씨. 암 진단 및/또는 모니터링을 위한 무세포 rna의 사용 방법
WO2016187234A1 (fr) 2015-05-18 2016-11-24 Karius, Inc. Compositions et procédés pour l'enrichissement de populations d'acides nucléiques
EP3310933B1 (fr) * 2015-06-17 2020-11-18 The Translational Genomics Research Institute Procédés pour l'obtention de molécules biologiques à partir d'un échantillon
US10692797B2 (en) * 2015-06-30 2020-06-23 Laird Technologies, Inc. Thermal interface materials with low secant modulus of elasticity and high thermal conductivity
US10870851B2 (en) 2015-10-06 2020-12-22 The Regents Of The University Of California Non-coding RNAs linked to immortality and associated methods and compositions
CN108369612A (zh) * 2015-11-04 2018-08-03 梅塔博隆股份有限公司 自动化样品质量评估
EP3978627A1 (fr) 2016-03-25 2022-04-06 Karius, Inc. Procédé utilisant des spike-ins d'acides nucléiques synthétiques
CA3059370C (fr) 2017-04-12 2022-05-10 Karius, Inc. Methodes d'analyse simultanee de l'adn et de l'arn dans des echantillonsmelanges
WO2018208892A1 (fr) * 2017-05-10 2018-11-15 Nantomics, Llc Arn circulant pour la détection, la prédiction et la surveillance du cancer
EP3625357A4 (fr) * 2017-05-16 2021-02-24 The Chinese University Of Hong Kong Analyse intégrative d'arn de plasma acellulaire et monocellulaire
JP7319553B2 (ja) * 2017-10-23 2023-08-02 シーゼット・バイオハブ・エスエフ・リミテッド・ライアビリティ・カンパニー 在胎週数および早産を予測する胎児発達のための非侵襲的分子時計
CN111526793A (zh) 2017-10-27 2020-08-11 朱诺诊断学公司 用于超低体积液体活检的设备、***和方法
AU2018365883A1 (en) 2017-11-07 2020-05-14 Nanthealth Labs, Inc. Targeted cell free nucleic acid analysis
EP3765592A4 (fr) 2018-03-16 2021-12-08 Karius Inc. Série d'échantillons pour différencier des acides nucléiques cibles d'acides nucléiques contaminants
AU2019373133A1 (en) * 2018-10-29 2021-06-17 Molecular Stethoscope, Inc. Characterization of bone marrow using cell-free messenger-RNA
US11512349B2 (en) 2018-12-18 2022-11-29 Grail, Llc Methods for detecting disease using analysis of RNA
US20210310067A1 (en) * 2019-01-24 2021-10-07 Illumina, Inc. Methods and systems for monitoring organ health and disease
CA3126990A1 (fr) * 2019-02-14 2020-08-20 Maneesh Jain Procede et systemes de determination d'un etat associe a la grossesse chez un sujet
AU2020253585A1 (en) * 2019-04-02 2021-11-18 Mission Bio, Inc. Methods, systems, and apparatus for nucleic acid detection
EP3973074A4 (fr) 2019-05-22 2023-09-06 Mission Bio, Inc. Méthode et appareil de séquençage ciblé simultané d'adn, d'arn et de protéine
US11948684B2 (en) * 2019-06-20 2024-04-02 Latha Chakravarthy Diagnostic process for disease detection using gene expression based multi layer PCA classifier
CN110964800B (zh) * 2019-09-20 2021-10-22 北京航空航天大学 用于预测早产风险的cfRNA标志物
EP4055180A4 (fr) * 2019-11-05 2023-12-06 Cofactor Genomics, Inc. Procédés et systèmes de traitement d'ensembles de données complexes utilisant l'intelligence artificielle et la déconvolution
EP4077710A4 (fr) * 2019-12-20 2024-02-21 Univ Utah Res Found Procédés et compositions pour le suivi et le diagnostic des états de santé et de maladies
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
AU2021236680A1 (en) * 2020-03-18 2022-10-27 Molecular Stethoscope, Inc. Systems and methods of detecting a risk of Alzheimer's disease using a circulating-free mRNA profiling assay
CN116234929A (zh) * 2020-08-13 2023-06-06 米尔维公司 用于确定对象的妊娠相关状态的方法和***

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5629147A (en) 1992-07-17 1997-05-13 Aprogenex, Inc. Enriching and identifying fetal cells in maternal blood for in situ hybridization
US5432054A (en) 1994-01-31 1995-07-11 Applied Imaging Method for separating rare cells from a population of cells
WO2000040749A2 (fr) * 1999-01-06 2000-07-13 Genenews Inc. Technique de detection de transcrits geniques dans le sang et leur utilisation
US20050123938A1 (en) * 1999-01-06 2005-06-09 Chondrogene Limited Method for the detection of osteoarthritis related gene transcripts in blood
US20080009467A1 (en) 2000-05-01 2008-01-10 Accera, Inc. Combinations of medium chain triglycerides and therapeutic agents for the treatment and prevention of alzheimers disease and other diseases resulting from reduced neuronal metabolism
US6727066B2 (en) 2000-07-28 2004-04-27 Incyte Corporation Genes expressed in treated human C3A liver cell cultures
US6664056B2 (en) * 2000-10-17 2003-12-16 The Chinese University Of Hong Kong Non-invasive prenatal monitoring
EP1506395A2 (fr) 2002-05-10 2005-02-16 Phase-1 Molecular Toxicology Inc. Genes predictifs d'une inflammation du foie
US20040180048A1 (en) 2002-07-12 2004-09-16 The Johns Hopkins University Neuronal and retinal gene expression patterns
US20040086511A1 (en) 2002-07-12 2004-05-06 The Johns Hopkins University Neuronal gene expression patterns
ATE533857T1 (de) 2003-01-17 2011-12-15 Univ Hong Kong Chinese Zirkulierende mrna als diagnostische marker für erkankungen die mit einer schwangerschaft zusammenhängen
US20060003342A1 (en) * 2004-01-15 2006-01-05 Bianchi Diana W Fetal RNA in amniotic fluid to determine gene expression in the developing fetus
JP2008515384A (ja) * 2004-07-21 2008-05-15 ザ・レジェンツ・オブ・ザ・ユニバーシティー・オブ・カリフォルニア 唾液トランスクリプトーム診断
US7713693B1 (en) * 2004-09-01 2010-05-11 University Of Louisiana At Monroe Human cancer cell specific gene transcript
US20060166242A1 (en) * 2005-01-06 2006-07-27 Mount Sinai Hospital Markers of pre-term labor
WO2008132752A2 (fr) * 2007-05-01 2008-11-06 Tel Hashomer Medical Research Infrastructure And Services Ltd. Procédés et trousses de prédiction de métastases d'un cancer
WO2009009457A1 (fr) 2007-07-06 2009-01-15 University Of Louisville Research Foundation, Inc. Microréseau de micro-arn spécifique de la maladie d'alzheimer et procédés apparentés
WO2009025852A2 (fr) * 2007-08-22 2009-02-26 Xenomics, Inc. Procédés d'utilisation d'arnmi pour la détection de la mort cellulaire in vivo
US8298768B2 (en) * 2007-11-29 2012-10-30 Complete Genomics, Inc. Efficient shotgun sequencing methods
AU2009207291B2 (en) * 2008-01-27 2014-11-06 Mor Research Applications Methods and compositions for diagnosing complications of pregnancy
US20110144076A1 (en) * 2008-05-01 2011-06-16 Michelle A Williams Preterm delivery diagnostic assay
US20110150775A1 (en) * 2008-06-01 2011-06-23 Tufts Medical Center, Inc. Genomic approaches to fetal treatment and diagnosis
US7888030B2 (en) 2008-08-21 2011-02-15 King's College London Biomarkers
MX2011004891A (es) 2008-11-13 2011-10-06 Modgene Llc Modificacion de la carga de beta amiloide en el tejido no cerebral.
EP2475781B1 (fr) 2009-09-11 2017-10-25 The Chinese University Of Hong Kong Procédés d'évaluation des pathologies hépatiques
US20120238469A1 (en) * 2009-12-08 2012-09-20 Cedars-Sinai Medical Center Diagnostic biomarker to identify women at risk for preterm delivery
WO2011156734A2 (fr) * 2010-06-11 2011-12-15 Hitachi Chemical Co., Ltd. Procédé de caractérisation de maladies vasculaires
US20130116151A1 (en) * 2010-07-08 2013-05-09 Pronota N.V. Biomarker for hypertensive disorders of pregnancy
SG10201505723UA (en) * 2010-07-23 2015-09-29 Harvard College Methods for detecting signatures of disease or conditions in bodily fluids
WO2013007708A1 (fr) 2011-07-08 2013-01-17 Helmholtz-Zentrum für Infektionsforschung GmbH Médicament pour le traitement du cancer du foie
CA2838562A1 (fr) 2011-08-08 2013-02-14 Eugenia Wang Biomarqueur pour maladie d'alzheimer et/ou trouble leger cognitif, et son utilisation
US20140304845A1 (en) 2011-10-31 2014-10-09 Merck Sharp & Dohme Corp. Alzheimer's disease signature markers and methods of use
US20160289762A1 (en) * 2012-01-27 2016-10-06 The Board Of Trustees Of The Leland Stanford Junior University Methods for profiliing and quantitating cell-free rna
EP2807277A4 (fr) 2012-01-27 2016-02-17 Univ Leland Stanford Junior Procédés de profilage et de quantification d'arn acellulaire
WO2014142752A1 (fr) * 2013-03-12 2014-09-18 Agency For Science, Technology And Research Biomarqueurs de pré-éclampsie
US11371098B2 (en) 2015-09-14 2022-06-28 Genfit Methods for diagnosing and evaluating non-alcoholic steatohepatitis

Also Published As

Publication number Publication date
US20220010381A1 (en) 2022-01-13
US20220290236A1 (en) 2022-09-15
US10240204B2 (en) 2019-03-26
JP2017063799A (ja) 2017-04-06
US20170145507A1 (en) 2017-05-25
CA2863035C (fr) 2023-08-29
HK1211624A1 (en) 2016-05-27
US20220213549A1 (en) 2022-07-07
CA2863035A1 (fr) 2013-08-01
AU2013211850B2 (en) 2017-03-02
AU2013211850A8 (en) 2017-06-29
EP2807277A2 (fr) 2014-12-03
US20160017420A1 (en) 2016-01-21
US10287632B2 (en) 2019-05-14
US20130252835A1 (en) 2013-09-26
US20210363584A1 (en) 2021-11-25
WO2013113012A2 (fr) 2013-08-01
US20220042098A1 (en) 2022-02-10
JP6320302B2 (ja) 2018-05-09
CN104334742A (zh) 2015-02-04
JP2015511122A (ja) 2015-04-16
US10155986B2 (en) 2018-12-18
US20170145508A1 (en) 2017-05-25
AU2013211850B8 (en) 2017-06-29
US20180357379A1 (en) 2018-12-13
EP2807277A4 (fr) 2016-02-17
US20190226029A1 (en) 2019-07-25
CN108359711A (zh) 2018-08-03
SG11201505515XA (en) 2015-09-29
US20200370121A1 (en) 2020-11-26
US20170145509A1 (en) 2017-05-25
US20200362416A1 (en) 2020-11-19
EP3584327A1 (fr) 2019-12-25
AU2013211850A1 (en) 2014-09-18
US10240200B2 (en) 2019-03-26
WO2013113012A3 (fr) 2014-11-06

Similar Documents

Publication Publication Date Title
SG10201906331TA (en) Methods for profiling and quantitating cell-free rna
EA201590027A1 (ru) Способы детекции заболеваний или состояний
MX341840B (es) Biomarcadores de microarn indicativos de la enfermedad de alzheimer.
NZ608384A (en) Biomarkers of renal injury
EP4306659A3 (fr) Procédé et kit pour déterminer l'origine tissulaire ou cellulaire d'adn
BR112013001752A2 (pt) método de detectar doenças ou condições usando células fagocídicas
WO2012167142A3 (fr) Quantification d'enzyme
NO20083957L (no) DNA-konformasjon
GB201216076D0 (en) Methods for obtaining a sequence
GB201009641D0 (en) Methods of monitoring conditions by sequence analysis
MY182773A (en) Method for indicating a presence or non-presence of aggressive prostate cancer
WO2013066369A3 (fr) Procédés de détection de maladie du greffon contre l'hôte
EA030186B9 (ru) Способ проведения количественных анализов
NZ605698A (en) Methods and compositions for diagnosis and prognosis of renal injury and renal failure
PH12016502411A1 (en) Method for methylation analysis
GB201206977D0 (en) An enzyme detection device
WO2011104517A3 (fr) Détection de capacitance en analyse électrochimique
PH12017500798A1 (en) Pna probes, kits and methods for detecting human papillomavirus genotypes of human papillomavirus
BR112014021993B8 (pt) "métodos para detecção de uma variação de nucleotídeo em uma sequência de ácido nucleico alvo através de um ensaio de ptoce"
MX2015012304A (es) Metodo no invasivo para la medicion de metabolitos para la salud de la piel.
EP2835643A4 (fr) Procédé de détection ou de quantification d'une substance à analyser, kit de détection ou de quantification d'une substance à analyser, et bandelette réactive pour immunochromatographie sur membrane utilisée pour la détection ou la quantification d'une substance à analyser
EP2584045A4 (fr) Procédé de détection d'une tumeur colorectale
WO2013112836A3 (fr) Biomarqueurs diagnostiques et pronostiques du cancer
BR112017023473A2 (pt) método de detecção e quantificação de ácido nucleico e composições
BR112012021878A2 (pt) método para detectar um deriva de clorofila livre de fitol em uma amostra, método de análise para determinar a quantidade de atividade de enzina em uma amostra e kit para determinar a quantidade de atividade de enzima em uma amostra