SG10201501879PA - Three-dimensional structure of isoprene synthase and its use thereof for generating variants - Google Patents
Three-dimensional structure of isoprene synthase and its use thereof for generating variantsInfo
- Publication number
- SG10201501879PA SG10201501879PA SG10201501879PA SG10201501879PA SG10201501879PA SG 10201501879P A SG10201501879P A SG 10201501879PA SG 10201501879P A SG10201501879P A SG 10201501879PA SG 10201501879P A SG10201501879P A SG 10201501879PA SG 10201501879P A SG10201501879P A SG 10201501879PA
- Authority
- SG
- Singapore
- Prior art keywords
- dimensional structure
- isoprene synthase
- generating variants
- variants
- generating
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/03—Carbon-oxygen lyases (4.2) acting on phosphates (4.2.3)
- C12Y402/03027—Isoprene synthase (4.2.3.27)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17219909P | 2009-04-23 | 2009-04-23 | |
US25583109P | 2009-10-28 | 2009-10-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201501879PA true SG10201501879PA (en) | 2015-05-28 |
Family
ID=42540820
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201501879PA SG10201501879PA (en) | 2009-04-23 | 2010-04-22 | Three-dimensional structure of isoprene synthase and its use thereof for generating variants |
Country Status (7)
Country | Link |
---|---|
US (2) | US8518686B2 (en) |
EP (1) | EP2421966A2 (en) |
CN (1) | CN102656265A (en) |
AU (1) | AU2010238770A1 (en) |
CA (1) | CA2759700A1 (en) |
SG (1) | SG10201501879PA (en) |
WO (1) | WO2010124146A2 (en) |
Families Citing this family (32)
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KR20100118973A (en) | 2007-12-13 | 2010-11-08 | 다니스코 유에스 인크. | Compositions and methods for producing isoprene |
JP2011518564A (en) | 2008-04-23 | 2011-06-30 | ダニスコ・ユーエス・インク | Isoprene synthase mutants for isoprene production by improved microorganisms |
MY169163A (en) | 2008-09-15 | 2019-02-19 | Danisco Us Inc | Increased isoprene production using the archaeal lower mevalonate pathway |
CA2737082A1 (en) * | 2008-09-15 | 2010-03-18 | Danisco Us Inc. | Increased isoprene production using mevalonate kinase and isoprene synthase |
WO2010124146A2 (en) | 2009-04-23 | 2010-10-28 | Danisco Us Inc. | Three-dimensional structure of isoprene synthase and its use thereof for generating variants |
TW201412988A (en) | 2009-06-17 | 2014-04-01 | Danisco Us Inc | Improved isoprene production using the dxp and mva pathway |
US20110039323A1 (en) * | 2009-08-14 | 2011-02-17 | Eric Lawrence Singsaas | Isoprene Production |
BR112012017345A2 (en) | 2009-12-23 | 2015-11-03 | Danisco Us Inc | "pgl compositions and methods for increased production of isoprene and other products with 6-phosphoglycololactonase (pgl)" |
US8933282B2 (en) | 2010-06-17 | 2015-01-13 | Danisco Us Inc. | Fuel compositions comprising isoprene derivatives |
US9273298B2 (en) | 2010-10-27 | 2016-03-01 | Danisco Us Inc. | Isoprene synthase variants for improved production of isoprene |
US8685702B2 (en) | 2010-12-22 | 2014-04-01 | Danisco Us Inc. | Compositions and methods for improved isoprene production using two types of ISPG enzymes |
BR112013016264A2 (en) | 2010-12-22 | 2018-06-19 | Danisco Us Inc | biological production of pentose sugars using recombinant cells |
CA2834379A1 (en) | 2011-04-29 | 2012-11-01 | The Goodyear Tire & Rubber Company | Production of mevalonate, isoprene, and isoprenoids using genes encoding polypeptides having thiolase, hmg-coa synthase and hmg-coa reductase enzymatic activities |
SG194690A1 (en) | 2011-04-29 | 2013-12-30 | Danisco Us Inc | Recombinant microorganisms for enhanced production of mevalonate,isoprene, and isoprenoids |
BR112014002661A2 (en) | 2011-08-04 | 2019-09-24 | Danisco Us Inc | isoprene production, isoprene precursors, and isoprenes with the use of acetoacetyl coa synthase |
AU2012332996A1 (en) | 2011-10-07 | 2014-04-24 | Danisco Us Inc. | Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene |
BR112014010053A8 (en) | 2011-10-27 | 2017-06-20 | Danisco Us Inc | Isoprene synthase variants with enhanced solubility for isoprene production |
US20140128645A1 (en) * | 2011-12-23 | 2014-05-08 | The Goodyear Tire & Rubber Company | Enhanced production of isoprene using marine bacterial cells |
EP2794876A1 (en) | 2011-12-23 | 2014-10-29 | Danisco US Inc. | Production of isoprene under reduced oxygen inlet levels |
BR112014014947A2 (en) | 2011-12-23 | 2020-10-27 | Danisco Us Inc. | marked isoprene production with the use of host cells having decreased ispa activity |
US9315831B2 (en) | 2012-03-30 | 2016-04-19 | Danisco Us Inc. | Direct starch to fermentable sugar as feedstock for the production of isoprene, isoprenoid precursor molecules, and/or isoprenoids |
US8895277B2 (en) * | 2012-05-02 | 2014-11-25 | Danisco Us Inc. | Legume isoprene synthase for production of isoprene |
US9163263B2 (en) | 2012-05-02 | 2015-10-20 | The Goodyear Tire & Rubber Company | Identification of isoprene synthase variants with improved properties for the production of isoprene |
WO2013181647A2 (en) | 2012-06-01 | 2013-12-05 | Danisco Us Inc. | Compositions and methods of producing isoprene and/or industrrial bio-products using anaerobic microorganisms |
EP2935364A2 (en) | 2012-12-21 | 2015-10-28 | Danisco US Inc. | Production of isoprene, isoprenoid, and isoprenoid precursors using an alternative lower mevalonate pathway |
US9850512B2 (en) | 2013-03-15 | 2017-12-26 | The Research Foundation For The State University Of New York | Hydrolysis of cellulosic fines in primary clarified sludge of paper mills and the addition of a surfactant to increase the yield |
SG11201508186XA (en) | 2013-04-10 | 2015-11-27 | Danisco Us Inc | Phosphoketolases for improved production of acetyl coenzyme a-derived metabolites, isoprene, isoprenoid precursors, and isoprenoids |
JPWO2015076392A1 (en) | 2013-11-22 | 2017-03-16 | 味の素株式会社 | Modified isoprene synthase |
WO2015127305A2 (en) | 2014-02-20 | 2015-08-27 | Danisco Us Inc. | Recombinant microorganisms for the enhanced production of mevalonate, isoprene, isoprenoid precursors, isoprenoids, and acetyl-coa-derived products |
US9951363B2 (en) | 2014-03-14 | 2018-04-24 | The Research Foundation for the State University of New York College of Environmental Science and Forestry | Enzymatic hydrolysis of old corrugated cardboard (OCC) fines from recycled linerboard mill waste rejects |
WO2016015021A1 (en) | 2014-07-24 | 2016-01-28 | The Regents Of The University Of California | Oxidative starch degradation by a new family of pmos |
CN108239630B (en) * | 2016-12-27 | 2021-07-16 | 武汉臻智生物科技有限公司 | Method for modifying terpene synthase |
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-
2010
- 2010-04-22 WO PCT/US2010/032134 patent/WO2010124146A2/en active Application Filing
- 2010-04-22 CN CN2010800275042A patent/CN102656265A/en active Pending
- 2010-04-22 SG SG10201501879PA patent/SG10201501879PA/en unknown
- 2010-04-22 US US12/765,825 patent/US8518686B2/en not_active Expired - Fee Related
- 2010-04-22 AU AU2010238770A patent/AU2010238770A1/en not_active Abandoned
- 2010-04-22 CA CA2759700A patent/CA2759700A1/en not_active Abandoned
- 2010-04-22 EP EP10719152A patent/EP2421966A2/en not_active Withdrawn
-
2013
- 2013-05-06 US US13/888,265 patent/US9175313B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO2010124146A2 (en) | 2010-10-28 |
US9175313B2 (en) | 2015-11-03 |
CN102656265A (en) | 2012-09-05 |
US8518686B2 (en) | 2013-08-27 |
US20130252303A1 (en) | 2013-09-26 |
EP2421966A2 (en) | 2012-02-29 |
WO2010124146A3 (en) | 2011-02-24 |
AU2010238770A1 (en) | 2011-11-03 |
US20110076743A1 (en) | 2011-03-31 |
CA2759700A1 (en) | 2010-10-28 |
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