PT3494133T - Recetores de células t anti-kras-g12d - Google Patents

Recetores de células t anti-kras-g12d

Info

Publication number
PT3494133T
PT3494133T PT177495801T PT17749580T PT3494133T PT 3494133 T PT3494133 T PT 3494133T PT 177495801 T PT177495801 T PT 177495801T PT 17749580 T PT17749580 T PT 17749580T PT 3494133 T PT3494133 T PT 3494133T
Authority
PT
Portugal
Prior art keywords
kras
cell receptors
receptors
cell
Prior art date
Application number
PT177495801T
Other languages
English (en)
Original Assignee
Us Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Health filed Critical Us Health
Publication of PT3494133T publication Critical patent/PT3494133T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C12N2015/8518—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic expressing industrially exogenous proteins, e.g. for pharmaceutical use, human insulin, blood factors, immunoglobulins, pseudoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/7051—T-cell receptor (TcR)-CD3 complex

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
PT177495801T 2016-08-02 2017-07-31 Recetores de células t anti-kras-g12d PT3494133T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662369883P 2016-08-02 2016-08-02

Publications (1)

Publication Number Publication Date
PT3494133T true PT3494133T (pt) 2022-09-28

Family

ID=59564253

Family Applications (1)

Application Number Title Priority Date Filing Date
PT177495801T PT3494133T (pt) 2016-08-02 2017-07-31 Recetores de células t anti-kras-g12d

Country Status (19)

Country Link
US (5) US10611816B2 (pt)
EP (2) EP4159751A1 (pt)
JP (3) JP6993402B2 (pt)
KR (1) KR102527052B1 (pt)
CN (2) CN109790211B (pt)
AU (2) AU2017306038B2 (pt)
CA (1) CA3032870A1 (pt)
DK (1) DK3494133T3 (pt)
ES (1) ES2928051T3 (pt)
HR (1) HRP20221183T1 (pt)
HU (1) HUE060121T2 (pt)
IL (2) IL301894A (pt)
LT (1) LT3494133T (pt)
PL (1) PL3494133T3 (pt)
PT (1) PT3494133T (pt)
RS (1) RS63615B1 (pt)
SG (2) SG10201913959WA (pt)
SI (1) SI3494133T1 (pt)
WO (1) WO2018026691A1 (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201913959WA (en) * 2016-08-02 2020-03-30 The United States Of America As Represented By The Secretary Anti-kras-g12d t cell receptors
GB201700621D0 (en) 2017-01-13 2017-03-01 Guest Ryan Dominic Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue
IL273254B1 (en) 2017-09-20 2024-05-01 Us Health HLA type II-restricted T cell receptors against RAS
CA3103983A1 (en) * 2018-06-19 2019-12-26 Biontech Us Inc. Neoantigens and uses thereof
US20220088190A1 (en) * 2019-01-25 2022-03-24 The Trustees Of The University Of Pennsylvania Compositions and Methods for Targeting Mutant RAS
GB2596461B (en) * 2019-02-20 2023-09-27 Fred Hutchinson Cancer Center Binding proteins specific for RAS neoantigens and uses thereof
CN110172089B (zh) * 2019-06-11 2020-01-07 北京鼎成肽源生物技术有限公司 一种kras突变多抗原组合、靶向kras突变肿瘤ctl及其应用
CN112110995A (zh) * 2019-06-19 2020-12-22 上海交通大学医学院 肿瘤新抗原多肽及其用途
CN112760290A (zh) * 2019-10-21 2021-05-07 郑州大学 携带突变的肿瘤驱动基因的干细胞及其用途
CN112759641B (zh) * 2019-11-01 2023-01-20 香雪生命科学技术（广东）有限公司 一种识别Kras G12V的高亲和力TCR
TW202132326A (zh) * 2019-11-05 2021-09-01 美國德州系統大學評議委員會 Hla限制性hormad1 t細胞受體及其用途
AU2020408017A1 (en) 2019-12-20 2022-07-14 Instil Bio (Uk) Limited Devices and methods for isolating tumor infiltrating lymphocytes and uses thereof
WO2021135178A1 (zh) * 2019-12-30 2021-07-08 华夏英泰（北京）生物技术有限公司 一种增强型t细胞受体star及其应用
CN116322734A (zh) * 2020-07-13 2023-06-23 美国卫生和人力服务部 针对具有g12d突变的ras的hla ii类限制性drb t细胞受体
IL303106A (en) * 2020-11-25 2023-07-01 Geneius Biotechnology Inc Antigen-specific T cells and methods for their preparation and use
JP2024507929A (ja) 2021-02-25 2024-02-21 アラウノス セラピューティクス インコーポレイテッド 多シストロン性発現カセットを含む組換えベクター及びそれらの使用方法
JP2024518378A (ja) 2021-05-05 2024-05-01 イマティクス バイオテクノロジーズ ゲーエムベーハー Ｐｒａｍｅに特異的に結合する抗原結合タンパク質
WO2023150562A1 (en) 2022-02-01 2023-08-10 Alaunos Therapeutics, Inc. Methods for activation and expansion of t cells
CN114920823B (zh) * 2022-05-27 2023-10-17 重庆医科大学 Tcr或其抗原结合片段及其应用
WO2024020537A2 (en) * 2022-07-22 2024-01-25 Board Of Regents, The University Of Texas System Cd3-expressing natural killer cells with enhanced function for adoptive immunotherapy
CN117777270A (zh) * 2022-09-29 2024-03-29 广州医科大学 一种t细胞受体(tcr)及其用途

Family Cites Families (17)

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US5776459A (en) * 1989-07-19 1998-07-07 Connetics Corporation TCR V beta 5 peptides
US20020150891A1 (en) * 1994-09-19 2002-10-17 Leroy E. Hood Diagnostic and therapeutic compositions and methods which utilize the t cell receptor beta gene region
US7709002B1 (en) 1996-04-19 2010-05-04 The United States Of America As Represented By The Department Of Health And Human Services Mutated ras peptides for generation of CD8+Cytotoxic T lymphocytes
GB2328689A (en) 1997-08-27 1999-03-03 Norsk Hydro As Peptides based on the p21 ras proto-oncogene protein for the treatment of cancer
EP1545204B1 (en) 2002-09-06 2016-08-10 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Immunotherapy with in vitro-selected antigen-specific lymphocytes after nonmyeloablative lymphodepleting chemotherapy
CA2674445C (en) 2007-01-12 2016-06-07 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Gp100-specific t cell receptors and related materials and methods of use
US8383099B2 (en) 2009-08-28 2013-02-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Adoptive cell therapy with young T cells
LT2618835T (lt) 2010-09-20 2017-10-10 Biontech Cell & Gene Therapies Gmbh Antigenui specifiniai t ląstelių receptoriai ir t ląstelių epitopai
WO2012129201A1 (en) 2011-03-22 2012-09-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of growing tumor infiltrating lymphocytes in gas-permeable containers
CN103974974A (zh) 2011-09-15 2014-08-06 美国卫生和人力服务部 识别hla-a1-或hla-cw7-限制的mage的t细胞受体
TW201335372A (zh) * 2011-11-30 2013-09-01 Nat Cancer Ct 誘導惡性幹細胞
US20160089434A1 (en) * 2013-06-03 2016-03-31 Novartis Ag Combinations of an anti-pd-l1 antibody and a mek inhibitor and/or a braf inhibitor
GB201313377D0 (en) * 2013-07-26 2013-09-11 Adaptimmune Ltd T cell receptors
GB201314404D0 (en) 2013-08-12 2013-09-25 Immunocore Ltd T Cell Receptors
JP6863893B2 (ja) 2014-11-26 2021-04-21 アメリカ合衆国 抗突然変異ｋｒａｓ ｔ細胞受容体
CA2998869A1 (en) 2015-09-15 2017-03-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services T cell receptors recognizing hla-cw8 restricted mutated kras
SG10201913959WA (en) * 2016-08-02 2020-03-30 The United States Of America As Represented By The Secretary Anti-kras-g12d t cell receptors

Also Published As

Publication number Publication date
KR20190064566A (ko) 2019-06-10
CA3032870A1 (en) 2018-02-08
HRP20221183T1 (hr) 2022-12-09
IL264425A (pt) 2019-03-31
IL264425B2 (en) 2023-09-01
EP3494133A1 (en) 2019-06-12
PL3494133T3 (pl) 2022-11-21
DK3494133T3 (da) 2022-09-19
EP3494133B1 (en) 2022-07-06
ES2928051T3 (es) 2022-11-15
KR102527052B1 (ko) 2023-04-27
SI3494133T1 (sl) 2022-11-30
US11840561B2 (en) 2023-12-12
JP2024045139A (ja) 2024-04-02
JP2022050400A (ja) 2022-03-30
US20210300988A1 (en) 2021-09-30
CN109790211B (zh) 2024-03-26
US20220089677A1 (en) 2022-03-24
US20240209059A1 (en) 2024-06-27
AU2017306038B2 (en) 2023-06-22
US20190177395A1 (en) 2019-06-13
US11897933B2 (en) 2024-02-13
JP2019527555A (ja) 2019-10-03
US10611816B2 (en) 2020-04-07
CN109790211A (zh) 2019-05-21
JP6993402B2 (ja) 2022-02-03
AU2023233125A1 (en) 2023-10-12
AU2017306038A1 (en) 2019-02-14
SG10201913959WA (en) 2020-03-30
RS63615B1 (sr) 2022-10-31
SG11201900654QA (en) 2019-02-27
JP7413338B2 (ja) 2024-01-15
IL301894A (en) 2023-06-01
IL264425B1 (en) 2023-05-01
US20200247869A1 (en) 2020-08-06
EP4159751A1 (en) 2023-04-05
US11208456B2 (en) 2021-12-28
WO2018026691A1 (en) 2018-02-08
LT3494133T (lt) 2022-12-12
CN118063591A (zh) 2024-05-24
HUE060121T2 (hu) 2023-01-28

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