PT3119782T - Compostos de 2,7-diazaspiro[3.5]nonano - Google Patents
Compostos de 2,7-diazaspiro[3.5]nonanoInfo
- Publication number
- PT3119782T PT3119782T PT157104860T PT15710486T PT3119782T PT 3119782 T PT3119782 T PT 3119782T PT 157104860 T PT157104860 T PT 157104860T PT 15710486 T PT15710486 T PT 15710486T PT 3119782 T PT3119782 T PT 3119782T
- Authority
- PT
- Portugal
- Prior art keywords
- diazaspiro
- nonane compounds
- nonane
- compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14160344 | 2014-03-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT3119782T true PT3119782T (pt) | 2018-04-17 |
Family
ID=50287962
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT157104860T PT3119782T (pt) | 2014-03-17 | 2015-03-17 | Compostos de 2,7-diazaspiro[3.5]nonano |
Country Status (17)
Country | Link |
---|---|
US (2) | US9617264B2 (pt) |
EP (1) | EP3119782B1 (pt) |
JP (2) | JP6574438B2 (pt) |
CN (1) | CN106103439B (pt) |
AU (1) | AU2015233642B2 (pt) |
CA (1) | CA2941196C (pt) |
DK (1) | DK3119782T3 (pt) |
EA (1) | EA032470B1 (pt) |
ES (1) | ES2666173T3 (pt) |
HR (1) | HRP20180585T1 (pt) |
HU (1) | HUE038764T2 (pt) |
NO (1) | NO3119782T3 (pt) |
PL (1) | PL3119782T3 (pt) |
PT (1) | PT3119782T (pt) |
RS (1) | RS57129B1 (pt) |
SI (1) | SI3119782T1 (pt) |
WO (1) | WO2015140132A1 (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201416352D0 (en) | 2014-09-16 | 2014-10-29 | Shire Internat Gmbh | Spirocyclic derivatives |
GB201416351D0 (en) | 2014-09-16 | 2014-10-29 | Shire Internat Gmbh | Heterocyclic derivatives |
JP2020537667A (ja) | 2017-10-17 | 2020-12-24 | ヴァンダービルト ユニバーシティー | ムスカリン性アセチルコリン受容体m4のアンタゴニスト |
US11325896B2 (en) | 2017-12-20 | 2022-05-10 | Vanderbilt University | Antagonists of the muscarinic acetylcholine receptor M4 |
EP4269394A4 (en) * | 2021-01-29 | 2024-07-24 | Korea Res Inst Chemical Tech | BENZOTHIAZOLE AND BENZIMIDAZOLE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, THEIR PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITION INCLUDING THEM AS ACTIVE INGREDIENT |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080247964A1 (en) * | 2006-05-08 | 2008-10-09 | Yuelian Xu | Substituted azaspiro derivatives |
CN101534818A (zh) * | 2006-09-15 | 2009-09-16 | 先灵公司 | 用于治疗疼痛和脂类代谢疾病的氮杂环丁烷和氮杂环丁酮衍生物 |
RU2524341C2 (ru) * | 2010-03-19 | 2014-07-27 | Пфайзер Инк. | Производные 2,3-дигидро-1н-инден-1-ил-2,7-диазаспиро[3.5]нонана и их применение в качестве антагонистов или обратных агонистов грелинового рецептора |
JP6399660B2 (ja) * | 2012-04-10 | 2018-10-03 | ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア | 癌治療用組成物および方法 |
LT2861566T (lt) | 2012-06-13 | 2017-02-10 | F. Hoffmann-La Roche Ag | Nauji diazaspirocikloalkanai ir azaspirocikloalkanai |
-
2015
- 2015-03-17 JP JP2016557898A patent/JP6574438B2/ja active Active
- 2015-03-17 PL PL15710486T patent/PL3119782T3/pl unknown
- 2015-03-17 NO NO15710486A patent/NO3119782T3/no unknown
- 2015-03-17 PT PT157104860T patent/PT3119782T/pt unknown
- 2015-03-17 ES ES15710486.0T patent/ES2666173T3/es active Active
- 2015-03-17 CA CA2941196A patent/CA2941196C/en active Active
- 2015-03-17 AU AU2015233642A patent/AU2015233642B2/en not_active Ceased
- 2015-03-17 US US15/121,790 patent/US9617264B2/en active Active
- 2015-03-17 DK DK15710486.0T patent/DK3119782T3/en active
- 2015-03-17 EA EA201691539A patent/EA032470B1/ru not_active IP Right Cessation
- 2015-03-17 SI SI201530219T patent/SI3119782T1/en unknown
- 2015-03-17 WO PCT/EP2015/055494 patent/WO2015140132A1/en active Application Filing
- 2015-03-17 RS RS20180427A patent/RS57129B1/sr unknown
- 2015-03-17 EP EP15710486.0A patent/EP3119782B1/en active Active
- 2015-03-17 CN CN201580013644.7A patent/CN106103439B/zh not_active Expired - Fee Related
- 2015-03-17 HU HUE15710486A patent/HUE038764T2/hu unknown
-
2017
- 2017-02-15 US US15/433,164 patent/US9750745B2/en active Active
-
2018
- 2018-04-12 HR HRP20180585TT patent/HRP20180585T1/hr unknown
-
2019
- 2019-05-20 JP JP2019094697A patent/JP2019147834A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
CN106103439A (zh) | 2016-11-09 |
PL3119782T3 (pl) | 2018-07-31 |
CA2941196A1 (en) | 2015-09-24 |
US9617264B2 (en) | 2017-04-11 |
WO2015140132A1 (en) | 2015-09-24 |
AU2015233642B2 (en) | 2017-08-03 |
HUE038764T2 (hu) | 2018-11-28 |
EA201691539A1 (ru) | 2017-01-30 |
EA032470B1 (ru) | 2019-05-31 |
US20170157137A1 (en) | 2017-06-08 |
CN106103439B (zh) | 2019-03-08 |
JP2019147834A (ja) | 2019-09-05 |
EP3119782B1 (en) | 2018-01-31 |
US20170015665A1 (en) | 2017-01-19 |
SI3119782T1 (en) | 2018-06-29 |
AU2015233642A1 (en) | 2016-09-08 |
ES2666173T3 (es) | 2018-05-03 |
DK3119782T3 (en) | 2018-03-12 |
JP6574438B2 (ja) | 2019-09-11 |
RS57129B1 (sr) | 2018-07-31 |
US9750745B2 (en) | 2017-09-05 |
CA2941196C (en) | 2019-09-03 |
JP2017507986A (ja) | 2017-03-23 |
HRP20180585T1 (hr) | 2018-07-13 |
EP3119782A1 (en) | 2017-01-25 |
NO3119782T3 (pt) | 2018-06-30 |
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