PE20171140A1 - ANTI HYPERALGESIC, ANTIALODINIC AND ANT-INFLAMMATORY PHARMACOLOGICAL COMBINATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN IT, AND ITS USE FOR THE TREATMENT OF NEUROPATHIC PAIN - Google Patents
ANTI HYPERALGESIC, ANTIALODINIC AND ANT-INFLAMMATORY PHARMACOLOGICAL COMBINATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN IT, AND ITS USE FOR THE TREATMENT OF NEUROPATHIC PAINInfo
- Publication number
- PE20171140A1 PE20171140A1 PE2017000033A PE2017000033A PE20171140A1 PE 20171140 A1 PE20171140 A1 PE 20171140A1 PE 2017000033 A PE2017000033 A PE 2017000033A PE 2017000033 A PE2017000033 A PE 2017000033A PE 20171140 A1 PE20171140 A1 PE 20171140A1
- Authority
- PE
- Peru
- Prior art keywords
- treatment
- neuropathic pain
- pharmaceutical compositions
- antialodinic
- ant
- Prior art date
Links
- 230000003070 anti-hyperalgesia Effects 0.000 title abstract 3
- 208000004296 neuralgia Diseases 0.000 title abstract 2
- 208000021722 neuropathic pain Diseases 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 230000000144 pharmacologic effect Effects 0.000 title 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 abstract 3
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 2
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 2
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 abstract 1
- ZRVUJXDFFKFLMG-UHFFFAOYSA-N Meloxicam Chemical group OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=NC=C(C)S1 ZRVUJXDFFKFLMG-UHFFFAOYSA-N 0.000 abstract 1
- 230000003574 anti-allodynic effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 abstract 1
- 229960001929 meloxicam Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- AYXYPKUFHZROOJ-ZETCQYMHSA-N pregabalin Chemical compound CC(C)C[C@H](CN)CC(O)=O AYXYPKUFHZROOJ-ZETCQYMHSA-N 0.000 abstract 1
- 229960001233 pregabalin Drugs 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invencion se refiere a una novedosa combinacion farmaceutica sinergica de un agente antihiperalgesico, antialodinico, analogo del acido gama-aminobutirico (GABA) y un agente antiinflamatorio, en donde el agente antihiperalgesico, antialodinico es Pregabalina, y el agente antiinflamatorio es Meloxicam. La presente invencion ademas esta dirigida a composiciones farmaceuticas que comprenden dicha combinacion. Dichas composiciones son utiles para la prevencion y/o tratamiento del dolor neuropatico ocasionado por diversas etiologiasThe present invention relates to a novel synergistic pharmaceutical combination of an antihyperalgesic, anti-allodynic, gamma-aminobutyric acid (GABA) analogue and an anti-inflammatory agent, wherein the antihyperalgesic, anti-allodynamic agent is Pregabalin, and the anti-inflammatory agent is Meloxicam. The present invention is further directed to pharmaceutical compositions comprising such a combination. Said compositions are useful for the prevention and / or treatment of neuropathic pain caused by various etiologies.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX2014008336A MX2014008336A (en) | 2014-07-07 | 2014-07-07 | Antihyperalgesic, antiallodynic and anti-inflammatory pharmacological combination, pharmaceutical compositions containing same and use thereof for treating neuropatic pain. |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20171140A1 true PE20171140A1 (en) | 2017-08-09 |
Family
ID=53938368
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2017000033A PE20171140A1 (en) | 2014-07-07 | 2015-07-07 | ANTI HYPERALGESIC, ANTIALODINIC AND ANT-INFLAMMATORY PHARMACOLOGICAL COMBINATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN IT, AND ITS USE FOR THE TREATMENT OF NEUROPATHIC PAIN |
Country Status (5)
Country | Link |
---|---|
BR (1) | BR112017000359A2 (en) |
CO (1) | CO2017001076A2 (en) |
MX (1) | MX2014008336A (en) |
PE (1) | PE20171140A1 (en) |
WO (1) | WO2016005897A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3687520A4 (en) * | 2017-09-28 | 2021-06-23 | Nevakar, Inc | Fixed dose combination formulations for treating pain |
MX2019008467A (en) * | 2019-07-16 | 2019-11-07 | Federico Amezcua Amezcua | A synergistic combination of s-ketorolaco and pregabalin in a pharmaceutical composition for the treatment of neuropathic pain. |
CN112353767A (en) * | 2020-11-16 | 2021-02-12 | 海南锦瑞制药有限公司 | Diltiazem hydrochloride and pregabalin composition, and preparation method and application thereof |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6129907A (en) | 1999-08-04 | 2000-10-10 | Colgate Palmolive Company | Stable hydrogenated lupulone antibacterial oral compositions |
JP4428053B2 (en) | 2002-02-05 | 2010-03-10 | 味の素株式会社 | Pharmaceutical composition containing gabapentin or pregabalin and N-type calcium channel antagonist |
DE10331305A1 (en) | 2003-07-10 | 2005-02-17 | Siemens Ag | Communication system, peer-to-peer message filtering computer and method for processing a peer-to-peer message |
WO2006123247A2 (en) | 2005-05-20 | 2006-11-23 | Pfizer Limited | Synergistic combinations of non-steroidal antiinflammatory drugs with alpha-delta-ligands |
JP5452494B2 (en) | 2007-10-09 | 2014-03-26 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | A pharmaceutical composition for the treatment of neuropathic pain conditions comprising benfotiamine and one or more pharmaceutically active agents |
DK2596784T3 (en) | 2007-11-23 | 2017-03-06 | Gruenenthal Gmbh | Tapentadol compositions |
MX336979B (en) | 2011-12-16 | 2016-02-09 | Senosiain S A De C V Lab | Antineuritic pharmaceutical combination and compositions. |
-
2014
- 2014-07-07 MX MX2014008336A patent/MX2014008336A/en unknown
-
2015
- 2015-07-07 WO PCT/IB2015/055127 patent/WO2016005897A1/en active Application Filing
- 2015-07-07 PE PE2017000033A patent/PE20171140A1/en unknown
- 2015-07-07 BR BR112017000359-7A patent/BR112017000359A2/en not_active Application Discontinuation
-
2017
- 2017-02-06 CO CONC2017/0001076A patent/CO2017001076A2/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2016005897A1 (en) | 2016-01-14 |
BR112017000359A2 (en) | 2018-06-26 |
MX2014008336A (en) | 2016-01-07 |
CO2017001076A2 (en) | 2017-05-31 |
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