MX9701856A - Preparacion de liposomas multi-vesiculares para la liberacion controlada de agentes activos. - Google Patents
Preparacion de liposomas multi-vesiculares para la liberacion controlada de agentes activos.Info
- Publication number
- MX9701856A MX9701856A MX9701856A MX9701856A MX9701856A MX 9701856 A MX9701856 A MX 9701856A MX 9701856 A MX9701856 A MX 9701856A MX 9701856 A MX9701856 A MX 9701856A MX 9701856 A MX9701856 A MX 9701856A
- Authority
- MX
- Mexico
- Prior art keywords
- liposomes
- multivesicular liposomes
- active substance
- biologically active
- preparation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/829—Liposomes, e.g. encapsulation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se divulgan liposomas multi-vasiculares (MVLs) que contienen sustancias biologicamente activas, los liposomas multivesiculares teniendo distribucion de tamaños definida, tamaño promedio ajustable, tamaño y numero ajustable de cámaras internas, y una tasa de liberacion controlada y variable de la sustancia biologicamente activa. El proceso implica encapsular al menos una sustancia biologicamente activa y opcionalmente un separador osmotico en un primer componente acuoso encapsulado dentro de los liposomas. La tasa de liberacion de la sustancia activa hacia el ambiente circundante en el que se introducen los liposomas puede ser reducida incrementando la osmolaridad del primer componente acuoso o incrementada reduciendo la osmolaridad.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/305,158 US5993850A (en) | 1994-09-13 | 1994-09-13 | Preparation of multivesicular liposomes for controlled release of encapsulated biologically active substances |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9701856A true MX9701856A (es) | 1998-07-31 |
Family
ID=23179585
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9701856A MX9701856A (es) | 1994-09-13 | 1997-03-12 | Preparacion de liposomas multi-vesiculares para la liberacion controlada de agentes activos. |
Country Status (14)
Country | Link |
---|---|
US (1) | US5993850A (es) |
EP (1) | EP0781123B1 (es) |
JP (1) | JP3026271B2 (es) |
KR (1) | KR100387561B1 (es) |
CN (1) | CN1096850C (es) |
AU (1) | AU697484B2 (es) |
BR (1) | BR9508913A (es) |
CA (1) | CA2199004C (es) |
DE (1) | DE69535297T2 (es) |
FI (1) | FI119621B (es) |
MX (1) | MX9701856A (es) |
NO (1) | NO323581B1 (es) |
NZ (2) | NZ292830A (es) |
WO (1) | WO1996008235A1 (es) |
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KR19980067138A (ko) * | 1997-01-31 | 1998-10-15 | 박원훈 | 유전자 또는 생물학적 활성 약물을 세포내로 효과적으로 전달하는 지방 유제 및 그것의 제조방법 |
US5891467A (en) * | 1997-01-31 | 1999-04-06 | Depotech Corporation | Method for utilizing neutral lipids to modify in vivo release from multivesicular liposomes |
US6106858A (en) * | 1997-09-08 | 2000-08-22 | Skyepharma, Inc. | Modulation of drug loading in multivescular liposomes |
US6306432B1 (en) * | 1997-09-08 | 2001-10-23 | Chiron Corporation | High and low load formulations of IGF-I in multivesicular liposomes |
NZ503513A (en) | 1997-09-18 | 2004-12-24 | Skyepharma Inc | Sustained-release liposomal anesthetic compositions |
IL135989A0 (en) * | 1997-11-14 | 2001-05-20 | Skyepharma Inc | Processes for the production of multivesicular liposomes |
EP1098610B1 (en) * | 1998-07-17 | 2009-04-15 | Pacira Pharmaceuticals, Inc. | Biodegradable compositions for the controlled release of encapsulated substances |
US20040037818A1 (en) * | 1998-07-30 | 2004-02-26 | Brand Stephen J. | Treatment for diabetes |
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US6897196B1 (en) * | 2001-02-07 | 2005-05-24 | The Regents Of The University Of California | pH sensitive lipids based on ortho ester linkers, composition and method |
DE10109897A1 (de) * | 2001-02-21 | 2002-11-07 | Novosom Ag | Fakultativ kationische Liposomen und Verwendung dieser |
US20050156340A1 (en) | 2004-01-20 | 2005-07-21 | E Ink Corporation | Preparation of capsules |
ATE373466T1 (de) * | 2001-11-13 | 2007-10-15 | Celator Pharmaceuticals Inc | Lipidträgerzusammensetzungen und verfahren zur verbesserten wirkstoffzurückhaltung |
US20040082521A1 (en) * | 2002-03-29 | 2004-04-29 | Azaya Therapeutics Inc. | Novel formulations of digitalis glycosides for treating cell-proliferative and other diseases |
WO2003100024A2 (en) * | 2002-05-24 | 2003-12-04 | Waratah Pharmaceuticals, Inc. | Treatment for diabetes |
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CA2501677A1 (en) | 2002-10-22 | 2004-05-06 | Waratah Pharmaceuticals, Inc. | Treatment of diabetes |
US20040229810A1 (en) * | 2002-10-22 | 2004-11-18 | Antonio Cruz | Gastrin compositions and formulations, and methods of use and preparation |
CN1747738B (zh) * | 2002-10-29 | 2010-11-24 | 川塞夫有限公司 | 缓释抗感染剂 |
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JP2006508126A (ja) * | 2002-11-06 | 2006-03-09 | アザヤ セラピューティクス インコーポレイティッド | 薬学的製剤のタンパク質安定化されたリポソーム製剤 |
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US20070110674A1 (en) * | 2005-07-29 | 2007-05-17 | Yuhong Xu | Sono-active liposomes and lipid particles and use thereof as contrast agents and active-agent delivery systems |
HUE029994T2 (en) | 2005-12-08 | 2017-04-28 | Insmed Inc | Lipid-based preparations of antinfectants for the treatment of lung infections |
CN101190183B (zh) * | 2006-11-29 | 2010-05-12 | 上海医药工业研究院 | 一种盐酸可乐定多泡脂质体及其制备方法 |
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US9114081B2 (en) | 2007-05-07 | 2015-08-25 | Insmed Incorporated | Methods of treating pulmonary disorders with liposomal amikacin formulations |
US9333214B2 (en) | 2007-05-07 | 2016-05-10 | Insmed Incorporated | Method for treating pulmonary disorders with liposomal amikacin formulations |
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US20100102142A1 (en) * | 2008-10-28 | 2010-04-29 | Daria Tagliareni | Scent dispenser assembly |
CN101756902B (zh) * | 2008-12-23 | 2011-10-05 | 上海医药工业研究院 | 一种可乐定多囊脂质体及其制备方法 |
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CN102764456B (zh) * | 2012-07-24 | 2014-10-15 | 上海交通大学 | 血管栓塞剂及其用途、制备方法 |
BR112015012351A8 (pt) | 2012-11-29 | 2019-10-01 | Insmed Inc | composição de antibiótico de glicopeptídeo à base de lipídeo estabilizado e uso de um componente lipídico, um componente de antibiótico de glicopeptídeo e um aminoácido ou derivado do mesmo |
FR3008900B1 (fr) * | 2013-07-25 | 2018-03-30 | Centre Nat Rech Scient | Nanoparticules lipidiques multicompartimentees |
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KR102069680B1 (ko) * | 2017-03-02 | 2020-01-23 | 단디바이오사이언스 주식회사 | 면역억제인자 제어물질을 포함하는 다중도메인캡슐, 이의 제조방법, 및 이를 포함하는 면역조절 조성물 |
CN106924185B (zh) * | 2017-03-29 | 2019-11-26 | 烟台大学 | 一种载有囊泡的多囊脂质体的制备方法 |
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KR102186704B1 (ko) * | 2019-02-18 | 2020-12-04 | (주)아이엠디팜 | 서방성 지질 전구 제제 및 이를 포함하는 지질 용액 형태의 서방성 주사용 약학 조성물 |
US11278494B1 (en) | 2021-01-22 | 2022-03-22 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
US11357727B1 (en) | 2021-01-22 | 2022-06-14 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
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CN113509440B (zh) * | 2021-03-26 | 2022-08-30 | 中国药科大学 | 一种高包封率酮咯酸多囊脂质体制备及提高其稳定性方法 |
CN113171343A (zh) * | 2021-05-14 | 2021-07-27 | 成都大学 | 一种局部注射用硫酸阿米卡星多囊脂质体及其制备方法 |
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CH588887A5 (es) * | 1974-07-19 | 1977-06-15 | Battelle Memorial Institute | |
US4897308A (en) * | 1975-06-30 | 1990-01-30 | L'oreal | Compositions comprising aqueous dispersions of lipid spheres |
US4078052A (en) * | 1976-06-30 | 1978-03-07 | The United States Of America As Represented By The Secretary Of Health, Education And Welfare | Large unilamellar vesicles (LUV) and method of preparing same |
US4086257A (en) * | 1976-10-12 | 1978-04-25 | Sears Barry D | Phosphatidyl quaternary ammonium compounds |
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JPS55153713A (en) * | 1979-05-02 | 1980-11-29 | Kureha Chem Ind Co Ltd | Pharmaceutical preparation of ribosome containing active substance |
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-
1994
- 1994-09-13 US US08/305,158 patent/US5993850A/en not_active Expired - Lifetime
-
1995
- 1995-09-13 KR KR1019970701650A patent/KR100387561B1/ko not_active IP Right Cessation
- 1995-09-13 AU AU35115/95A patent/AU697484B2/en not_active Ceased
- 1995-09-13 JP JP8510312A patent/JP3026271B2/ja not_active Expired - Fee Related
- 1995-09-13 BR BR9508913A patent/BR9508913A/pt not_active IP Right Cessation
- 1995-09-13 CN CN95196186A patent/CN1096850C/zh not_active Expired - Fee Related
- 1995-09-13 WO PCT/US1995/011609 patent/WO1996008235A1/en active IP Right Grant
- 1995-09-13 NZ NZ292830A patent/NZ292830A/en not_active IP Right Cessation
- 1995-09-13 EP EP95931820A patent/EP0781123B1/en not_active Expired - Lifetime
- 1995-09-13 NZ NZ334561A patent/NZ334561A/xx not_active IP Right Cessation
- 1995-09-13 CA CA002199004A patent/CA2199004C/en not_active Expired - Lifetime
- 1995-09-13 DE DE69535297T patent/DE69535297T2/de not_active Expired - Lifetime
-
1997
- 1997-03-12 MX MX9701856A patent/MX9701856A/es unknown
- 1997-03-12 NO NO19971149A patent/NO323581B1/no not_active IP Right Cessation
- 1997-03-12 FI FI971037A patent/FI119621B/fi active
Also Published As
Publication number | Publication date |
---|---|
JP3026271B2 (ja) | 2000-03-27 |
EP0781123A4 (en) | 2000-12-20 |
AU697484B2 (en) | 1998-10-08 |
BR9508913A (pt) | 1997-12-30 |
US5993850A (en) | 1999-11-30 |
FI119621B (fi) | 2009-01-30 |
CA2199004C (en) | 2008-02-19 |
FI971037A (fi) | 1997-05-12 |
WO1996008235A1 (en) | 1996-03-21 |
NO971149L (no) | 1997-05-13 |
NZ334561A (en) | 2000-01-28 |
JPH10502667A (ja) | 1998-03-10 |
NZ292830A (en) | 1999-04-29 |
CA2199004A1 (en) | 1996-03-21 |
EP0781123B1 (en) | 2006-11-15 |
DE69535297T2 (de) | 2007-05-16 |
FI971037A0 (fi) | 1997-03-12 |
EP0781123A1 (en) | 1997-07-02 |
KR100387561B1 (ko) | 2003-10-08 |
CN1096850C (zh) | 2002-12-25 |
NO971149D0 (no) | 1997-03-12 |
CN1166136A (zh) | 1997-11-26 |
AU3511595A (en) | 1996-03-29 |
DE69535297D1 (de) | 2006-12-28 |
NO323581B1 (no) | 2007-06-11 |
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