MX366754B - Método para producir compuesto de pirimidin-1-ol e intermedio de este. - Google Patents

Método para producir compuesto de pirimidin-1-ol e intermedio de este.

Info

Publication number
MX366754B
MX366754B MX2017001222A MX2017001222A MX366754B MX 366754 B MX366754 B MX 366754B MX 2017001222 A MX2017001222 A MX 2017001222A MX 2017001222 A MX2017001222 A MX 2017001222A MX 366754 B MX366754 B MX 366754B
Authority
MX
Mexico
Prior art keywords
producing
pyrimidin
substituted
compound
ols
Prior art date
Application number
MX2017001222A
Other languages
English (en)
Other versions
MX2017001222A (es
Inventor
Watanabe Yuzo
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of MX2017001222A publication Critical patent/MX2017001222A/es
Publication of MX366754B publication Critical patent/MX366754B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se proporciona un método para producir pirimidin-5-ol disustituido en las posiciones 2 y 4 y, especialmente, 2,4-dimetilpirimidin-5-ol y un intermedio de este utilizado en la producción industrial. El método de producción de acuerdo con la presente invención incluye una etapa de producción de pirimidin-5-ol disustituido en las posiciones 2 y 4 de acuerdo con una reacción de hidrólisis de un compuesto de tipo 5-(4-(nitrofenil)oxi)pirimidina disustituida en las posiciones 2 y 4 y es adecuado para la producción industrial ya que se puede utilizar un material de partida barato y fácil de conseguir, la regioselectividad de un grupo sustituyente se controla fácilmente, las impurezas se controlan fácilmente y se puede producir pirimidin-5-ol disustituido en las posiciones 2,4 sin utilizar reactivos e intermedios que provoquen riesgos, problemas de salud y similares.
MX2017001222A 2014-08-06 2015-08-03 Método para producir compuesto de pirimidin-1-ol e intermedio de este. MX366754B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462033665P 2014-08-06 2014-08-06
PCT/JP2015/071930 WO2016021539A1 (ja) 2014-08-06 2015-08-03 ピリミジン－１－オール化合物の製造方法及びその中間体

Publications (2)

Publication Number Publication Date
MX2017001222A MX2017001222A (es) 2017-05-01
MX366754B true MX366754B (es) 2019-07-23

Family

ID=55263805

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017001222A MX366754B (es) 2014-08-06 2015-08-03 Método para producir compuesto de pirimidin-1-ol e intermedio de este.

Country Status (12)

Country Link
US (1) US10065930B2 (es)
EP (1) EP3178814B1 (es)
JP (1) JP6283748B2 (es)
KR (1) KR102325655B1 (es)
CN (1) CN107074780B (es)
ES (1) ES2731648T3 (es)
HU (1) HUE043849T2 (es)
IL (1) IL250223B (es)
MX (1) MX366754B (es)
RU (1) RU2681937C2 (es)
SG (1) SG11201700603TA (es)
WO (1) WO2016021539A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113214164B (zh) * 2021-05-20 2022-10-18 广西天铭药业有限公司 一种莱博雷生中间体2,4-二甲基嘧啶-5-醇的合成方法
ES2933074B2 (es) 2021-07-26 2023-09-29 Moehs Iberica Sl Procedimiento de sintesis de 2,4-dimetilpirimidin-5-ol, nuevos intermedios de dicho procedimiento y uso del producto en la sintesis de lemborexant

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3311703A1 (de) 1983-03-30 1984-10-04 Bayer Ag, 5090 Leverkusen Harnstoffderivate
DE3431272A1 (de) * 1984-08-25 1986-03-06 Bayer Ag, 5090 Leverkusen Substituierte phenylharnstoffe
JPS6229266A (ja) * 1985-07-29 1987-02-07 Matsushita Graphic Commun Syst Inc 自動利得制御回路
JPH0684358B2 (ja) 1986-06-11 1994-10-26 帝国化学産業株式会社 アルキルチオフエニルピリミジン誘導体
JPH0684359B2 (ja) 1986-06-11 1994-10-26 帝国化学産業株式会社 ２−（ｐ−アルコキシカルボニル）フエニルピリミジン誘導体
JP2655359B2 (ja) 1990-01-25 1997-09-17 富士写真フイルム株式会社 芳香族求核置換反応による芳香族アミン類、芳香族アルコール類、芳香族チオール類の合成法
SG34208A1 (en) 1995-03-01 1996-12-06 Guy Andrew Vaz Blast and fragment resistant polyurethane boot sole for safety footwear
WO1996034877A1 (en) 1995-05-05 1996-11-07 Human Genome Sciences, Inc. Human neuropeptide receptor
US6159605A (en) 1997-02-18 2000-12-12 Dainichiseika Color & Chemicals Mfg. Co., Ltd. Ink-jet recording sheet
US6166193A (en) 1997-07-25 2000-12-26 Board Of Regents, University Of Texas System Polynucleotides encoding MY1 receptor
KR100327888B1 (ko) 1999-07-14 2002-03-09 정숭렬 도로포장 파손촉진 시험장치의 무선제어 시스템
ES2587564T1 (es) * 2001-08-10 2016-10-25 Shionogi & Co., Ltd. Agente antiviral
PE20081229A1 (es) 2006-12-01 2008-08-28 Merck & Co Inc Antagonistas de receptor de orexina de diazepam sustituido
BR112013006594B1 (pt) * 2010-09-22 2021-08-17 Eisai R&D Management Co., Ltd Composto ciclopropano antagonista de receptor da orexina e composição farmacêutica
WO2013123240A1 (en) 2012-02-17 2013-08-22 Eisai R&D Management Co., Ltd Methods and compounds useful in the synthesis of orexin-2 receptor antagonists

Also Published As

Publication number Publication date
US10065930B2 (en) 2018-09-04
SG11201700603TA (en) 2017-03-30
MX2017001222A (es) 2017-05-01
JPWO2016021539A1 (ja) 2017-04-27
KR20170035917A (ko) 2017-03-31
RU2681937C2 (ru) 2019-03-14
US20170204068A1 (en) 2017-07-20
RU2017102349A3 (es) 2018-10-18
HUE043849T2 (hu) 2019-09-30
WO2016021539A1 (ja) 2016-02-11
EP3178814A4 (en) 2018-04-04
ES2731648T3 (es) 2019-11-18
JP6283748B2 (ja) 2018-02-21
IL250223A0 (en) 2017-03-30
CN107074780A (zh) 2017-08-18
EP3178814A1 (en) 2017-06-14
IL250223B (en) 2019-05-30
KR102325655B1 (ko) 2021-11-15
RU2017102349A (ru) 2018-09-06
EP3178814B1 (en) 2019-04-10
CN107074780B (zh) 2020-06-12

Similar Documents

Publication Publication Date Title
PH12019501842A1 (en) Bicyclic compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors
PH12016502177A1 (en) Processes of preparing a jak1 inhibitor and new forms thereto
PH12019502286A1 (en) Process for preparing an optically active pyrimidinium compounds
MY172391A (en) Processes for preparing dihydropyrimidine derivatives and intermediates thereof
MX2016013557A (es) Produccion de 4-metil-tetrahidropiranos 2-sustituidos a partir de materiales de partida con contenido de 2-alquil-4,4-dimetil-1,3-di oxanos.
TW201613886A (en) 3-amino-1,5,6,7-tetrahydro-4h-indol-4-ones
MX2017004672A (es) Proceso para la preparacion de treprostinil.
MX2016013555A (es) Produccion de 4-hidroxi-4-metil-tetrahidropiranos 2-sustituidos a partir de materiales de partida que contienen 2-alquil-4,4-dimetil-1,3-dioxanos.
MX2017004739A (es) Proceso estereoselectivo para obtener metilamidas del acido (z)-5-cicliloxi-2[(e)-metoximino]-3-metil-pent-3-enico usando mezcla de isomeros e, z e intermediarios de aquellas.
TR201905217T4 (tr) Kopanlisib ve bunun dihidroklorid tuzunun sentezi.
PH12016501941A1 (en) Use of heterocyclic compounds for controlling nematodes
MX369501B (es) Proceso para la preparación de 5-fluoro-1h-pirazoles partiendo de hexafluoropropeno.
TW201613871A (en) Process for the preparation of 5-fluoro-1H-pyrazoles starting from hexafluoropropene
MX2021011971A (es) Proceso para preparar cicloserinas sustituidas.
MX2017011330A (es) Proceso quimico para preparar derivados de pirimidina y sus intermediarios.
IN2015CH01182A (es)
PH12020551791A1 (en) Methods for the production of methacrylates
PH12016501613B1 (en) Pyrazines modulators of gpr6
MX2019004024A (es) Metodo para preparar acetofenonas sustituidas con ciclopropilo.
MX366754B (es) Método para producir compuesto de pirimidin-1-ol e intermedio de este.
MX2016017367A (es) Dioxido de zirconio, producto refractario, uso de dioxido de zirconio, procedimiento para la fabricacion de un producto refractario asi como un producto refractario fabricado mediante el mismo.
MX2016009325A (es) Metodo para la preparacion de 1-alquil-3-difluorometil-5-fluor-1h- pirazol-4-carbaldehidos y 1-alquil-3-difluorometil-5-fluor-1h-pira zol-4-carboxilatos.
MX2021004996A (es) Preparacion de 4-metiltetrahidropiranos 2-sustituidos a partir de 4-hidroxi-4-metiltetrahidropiranos 2-sustituidos como materiales de partida.
MX2017007670A (es) Metodo de manufactura de proteina.
MX2017007931A (es) Nuevas formas cristalinas de la sal de monosodio del foramsulfuron.

Legal Events

Date Code Title Description
FG Grant or registration