MX2019013614A - Seleccion y uso de fracciones de celulas del cordon umbilical adecuadas para trasplante. - Google Patents

Seleccion y uso de fracciones de celulas del cordon umbilical adecuadas para trasplante.

Info

Publication number
MX2019013614A
MX2019013614A MX2019013614A MX2019013614A MX2019013614A MX 2019013614 A MX2019013614 A MX 2019013614A MX 2019013614 A MX2019013614 A MX 2019013614A MX 2019013614 A MX2019013614 A MX 2019013614A MX 2019013614 A MX2019013614 A MX 2019013614A
Authority
MX
Mexico
Prior art keywords
transplantation
cord blood
selection
umbilical cord
expanded
Prior art date
Application number
MX2019013614A
Other languages
English (en)
Inventor
Tony Peled
Cohen Einat Galamidi
David Snyder
Original Assignee
Gamida Cell Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gamida Cell Ltd filed Critical Gamida Cell Ltd
Publication of MX2019013614A publication Critical patent/MX2019013614A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0278—Physical preservation processes
    • A01N1/0284—Temperature processes, i.e. using a designated change in temperature over time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4621—Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/46434—Antigens related to induction of tolerance to non-self
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Se proporcionan procedimientos para selección de unidades de sangre del cordón umbilical para expansión ex vivo, separación de fracciones positivas para CD133+/CD34+ y negativas para CD133+/CD34+ sin cultivar, procedimientos para expandir la fracción de CD133+/CD34+ seleccionada, selección de poblaciones expandidas de células sanguíneas del cordón umbilical CD133+/CD34+ para trasplante a sujetos con necesidad de las mismas y el uso terapéutico de fracciones de sangre del cordón umbilical CD133+/CD34+ expandidas ex vivo, seleccionadas adecuadamente y CD133/CD34 negativas sin seleccionar para su trasplante en el entorno clínico, para tratamiento de neoplasias hematológicas malignas. La presente invención también se refiere a kits que comprenden las fracciones de sangre del cordón umbilical expandidas y sin seleccionar.
MX2019013614A 2017-05-16 2017-05-16 Seleccion y uso de fracciones de celulas del cordon umbilical adecuadas para trasplante. MX2019013614A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IL2017/050551 WO2018211487A1 (en) 2017-05-16 2017-05-16 Selection and use of umbilical cord cell fractions suitable for transplantation

Publications (1)

Publication Number Publication Date
MX2019013614A true MX2019013614A (es) 2020-07-20

Family

ID=64273439

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019013614A MX2019013614A (es) 2017-05-16 2017-05-16 Seleccion y uso de fracciones de celulas del cordon umbilical adecuadas para trasplante.

Country Status (6)

Country Link
US (2) US11746325B2 (es)
AU (1) AU2017414804A1 (es)
BR (1) BR112019024077A2 (es)
CA (1) CA3064055A1 (es)
MX (1) MX2019013614A (es)
WO (1) WO2018211487A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3063674A1 (en) 2017-05-16 2018-11-22 Gamida-Cell Ltd. Selection and use of umbilical cord cell fractions suitable for transplantation
US11746325B2 (en) 2017-05-16 2023-09-05 Gamida Cell Ltd. Selection and use of umbilical cord cell fractions suitable for transplantation
US20220378840A1 (en) * 2019-11-29 2022-12-01 Rutgers, The State University Of New Jersey Compositions, kits and methods for storage of blood products and methods of use thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL152904A0 (en) 2002-01-24 2003-06-24 Gamida Cell Ltd Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations
WO2004096972A2 (en) 2003-05-02 2004-11-11 Insception Bioscience, Inc. Apparatus and methods for amplification of blood stem cell numbers
US8187876B2 (en) 2004-07-14 2012-05-29 Gamida Cell Ltd. Expansion of stem/progenitor cells by inhibition of enzymatic reactions catalyzed by the Sir2 family of enzymes
US8846393B2 (en) 2005-11-29 2014-09-30 Gamida-Cell Ltd. Methods of improving stem cell homing and engraftment
WO2007063545A2 (en) 2005-11-29 2007-06-07 Gamida-Cell Ltd. Methods of improving stem cell homing and engraftment
RU2360965C1 (ru) 2007-11-01 2009-07-10 Общество с ограниченной ответственностью "Лаборатория клеточного мониторинга" СПОСОБ УВЕЛИЧЕНИЯ КОЛИЧЕСТВА ГЕМОПОЭТИЧЕСКИХ НЕДИФФЕРЕНЦИРОВАННЫХ СТВОЛОВЫХ КЛЕТОК ПАЦИЕНТА ex vivo
WO2010128510A1 (en) 2009-05-07 2010-11-11 Gamida-Cell Ltd. Methods for selecting expanded stem cell populations
WO2010132315A1 (en) 2009-05-13 2010-11-18 Endgenitor Technologies, Inc. Enhanced hematopoietic stem cell engraftment
PT106225B (pt) 2012-03-23 2017-11-03 Inst Superior Técnico Processo de expansão ex vivo de células estaminais em biorreactor
IL302486A (en) 2015-06-24 2023-06-01 Hoffmann La Roche Antibodies against the transnephrine receptor with adapted affinity
BR112018011327A2 (pt) 2015-12-04 2018-12-04 Hutchinson Fred Cancer Res usos de populações expandidas de células-tronco/progenitoras hematopoiéticas
US11746325B2 (en) 2017-05-16 2023-09-05 Gamida Cell Ltd. Selection and use of umbilical cord cell fractions suitable for transplantation
CA3063674A1 (en) 2017-05-16 2018-11-22 Gamida-Cell Ltd. Selection and use of umbilical cord cell fractions suitable for transplantation
CL2019003272A1 (es) 2019-11-14 2020-05-29 Gamida Cell Ltd Selección y uso de fracciones de células del cordón umbilical adecuadas para trasplante.

Also Published As

Publication number Publication date
WO2018211487A1 (en) 2018-11-22
US20200172863A1 (en) 2020-06-04
US20230340410A1 (en) 2023-10-26
BR112019024077A2 (pt) 2020-06-02
US11746325B2 (en) 2023-09-05
AU2017414804A1 (en) 2020-01-02
CA3064055A1 (en) 2018-11-22

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