MX2019013614A - Seleccion y uso de fracciones de celulas del cordon umbilical adecuadas para trasplante. - Google Patents
Seleccion y uso de fracciones de celulas del cordon umbilical adecuadas para trasplante.Info
- Publication number
- MX2019013614A MX2019013614A MX2019013614A MX2019013614A MX2019013614A MX 2019013614 A MX2019013614 A MX 2019013614A MX 2019013614 A MX2019013614 A MX 2019013614A MX 2019013614 A MX2019013614 A MX 2019013614A MX 2019013614 A MX2019013614 A MX 2019013614A
- Authority
- MX
- Mexico
- Prior art keywords
- transplantation
- cord blood
- selection
- umbilical cord
- expanded
- Prior art date
Links
- 238000002054 transplantation Methods 0.000 title abstract 3
- 210000003954 umbilical cord Anatomy 0.000 title 1
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 abstract 6
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 abstract 6
- 210000004700 fetal blood Anatomy 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 2
- 208000002250 Hematologic Neoplasms Diseases 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0278—Physical preservation processes
- A01N1/0284—Temperature processes, i.e. using a designated change in temperature over time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4621—Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/46434—Antigens related to induction of tolerance to non-self
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Developmental Biology & Embryology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Dentistry (AREA)
- Environmental Sciences (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Se proporcionan procedimientos para selección de unidades de sangre del cordón umbilical para expansión ex vivo, separación de fracciones positivas para CD133+/CD34+ y negativas para CD133+/CD34+ sin cultivar, procedimientos para expandir la fracción de CD133+/CD34+ seleccionada, selección de poblaciones expandidas de células sanguíneas del cordón umbilical CD133+/CD34+ para trasplante a sujetos con necesidad de las mismas y el uso terapéutico de fracciones de sangre del cordón umbilical CD133+/CD34+ expandidas ex vivo, seleccionadas adecuadamente y CD133/CD34 negativas sin seleccionar para su trasplante en el entorno clínico, para tratamiento de neoplasias hematológicas malignas. La presente invención también se refiere a kits que comprenden las fracciones de sangre del cordón umbilical expandidas y sin seleccionar.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IL2017/050551 WO2018211487A1 (en) | 2017-05-16 | 2017-05-16 | Selection and use of umbilical cord cell fractions suitable for transplantation |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019013614A true MX2019013614A (es) | 2020-07-20 |
Family
ID=64273439
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019013614A MX2019013614A (es) | 2017-05-16 | 2017-05-16 | Seleccion y uso de fracciones de celulas del cordon umbilical adecuadas para trasplante. |
Country Status (6)
Country | Link |
---|---|
US (2) | US11746325B2 (es) |
AU (1) | AU2017414804A1 (es) |
BR (1) | BR112019024077A2 (es) |
CA (1) | CA3064055A1 (es) |
MX (1) | MX2019013614A (es) |
WO (1) | WO2018211487A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3063674A1 (en) | 2017-05-16 | 2018-11-22 | Gamida-Cell Ltd. | Selection and use of umbilical cord cell fractions suitable for transplantation |
US11746325B2 (en) | 2017-05-16 | 2023-09-05 | Gamida Cell Ltd. | Selection and use of umbilical cord cell fractions suitable for transplantation |
US20220378840A1 (en) * | 2019-11-29 | 2022-12-01 | Rutgers, The State University Of New Jersey | Compositions, kits and methods for storage of blood products and methods of use thereof |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL152904A0 (en) | 2002-01-24 | 2003-06-24 | Gamida Cell Ltd | Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations |
WO2004096972A2 (en) | 2003-05-02 | 2004-11-11 | Insception Bioscience, Inc. | Apparatus and methods for amplification of blood stem cell numbers |
US8187876B2 (en) | 2004-07-14 | 2012-05-29 | Gamida Cell Ltd. | Expansion of stem/progenitor cells by inhibition of enzymatic reactions catalyzed by the Sir2 family of enzymes |
US8846393B2 (en) | 2005-11-29 | 2014-09-30 | Gamida-Cell Ltd. | Methods of improving stem cell homing and engraftment |
WO2007063545A2 (en) | 2005-11-29 | 2007-06-07 | Gamida-Cell Ltd. | Methods of improving stem cell homing and engraftment |
RU2360965C1 (ru) | 2007-11-01 | 2009-07-10 | Общество с ограниченной ответственностью "Лаборатория клеточного мониторинга" | СПОСОБ УВЕЛИЧЕНИЯ КОЛИЧЕСТВА ГЕМОПОЭТИЧЕСКИХ НЕДИФФЕРЕНЦИРОВАННЫХ СТВОЛОВЫХ КЛЕТОК ПАЦИЕНТА ex vivo |
WO2010128510A1 (en) | 2009-05-07 | 2010-11-11 | Gamida-Cell Ltd. | Methods for selecting expanded stem cell populations |
WO2010132315A1 (en) | 2009-05-13 | 2010-11-18 | Endgenitor Technologies, Inc. | Enhanced hematopoietic stem cell engraftment |
PT106225B (pt) | 2012-03-23 | 2017-11-03 | Inst Superior Técnico | Processo de expansão ex vivo de células estaminais em biorreactor |
IL302486A (en) | 2015-06-24 | 2023-06-01 | Hoffmann La Roche | Antibodies against the transnephrine receptor with adapted affinity |
BR112018011327A2 (pt) | 2015-12-04 | 2018-12-04 | Hutchinson Fred Cancer Res | usos de populações expandidas de células-tronco/progenitoras hematopoiéticas |
US11746325B2 (en) | 2017-05-16 | 2023-09-05 | Gamida Cell Ltd. | Selection and use of umbilical cord cell fractions suitable for transplantation |
CA3063674A1 (en) | 2017-05-16 | 2018-11-22 | Gamida-Cell Ltd. | Selection and use of umbilical cord cell fractions suitable for transplantation |
CL2019003272A1 (es) | 2019-11-14 | 2020-05-29 | Gamida Cell Ltd | Selección y uso de fracciones de células del cordón umbilical adecuadas para trasplante. |
-
2017
- 2017-05-16 US US16/614,057 patent/US11746325B2/en active Active
- 2017-05-16 CA CA3064055A patent/CA3064055A1/en active Pending
- 2017-05-16 AU AU2017414804A patent/AU2017414804A1/en active Pending
- 2017-05-16 WO PCT/IL2017/050551 patent/WO2018211487A1/en active Application Filing
- 2017-05-16 MX MX2019013614A patent/MX2019013614A/es unknown
- 2017-05-16 BR BR112019024077-2A patent/BR112019024077A2/pt unknown
-
2023
- 2023-06-28 US US18/343,187 patent/US20230340410A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2018211487A1 (en) | 2018-11-22 |
US20200172863A1 (en) | 2020-06-04 |
US20230340410A1 (en) | 2023-10-26 |
BR112019024077A2 (pt) | 2020-06-02 |
US11746325B2 (en) | 2023-09-05 |
AU2017414804A1 (en) | 2020-01-02 |
CA3064055A1 (en) | 2018-11-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2020005634A (es) | Composiciones y metodos para mejorar los linfocitos infiltrantes de tumor para terapia celular adoptiva. | |
MX2020006688A (es) | Celulas presentadoras de antigenos artificiales y metodos de uso. | |
ZA201905822B (en) | Antibodies against pd-l1 | |
SG10201808258SA (en) | Improved methods for manufacturing adoptive cell therapies | |
PH12019502485A1 (en) | Expansion of yo t cells, compositions, and methods of use thereof | |
EA202091333A1 (ru) | Способы активации, модификации и экспансии t-клеток для лечения рака и связанных с ним злокачественных заболеваний | |
CY1123343T1 (el) | Παραγωγη μιας τραπεζας μεσεγχυματικων στρωματικων κυτταρων απο τα ομαδοποιημενα μονοπυρηνα κυτταρα πολλαπλων δοτων μυελου των οστων | |
BR112015030972A8 (pt) | células sc-beta e composições e métodos para geração das mesmas | |
MX2018004875A (es) | Metodos para cultivar celulas y kits y aparatos para ello. | |
MX2019007890A (es) | Compuestos de 1h-pirrol-2,5-diona y metodos de uso de los mismos para inducir la auto-renovacion de celulas madre/progenitoras de soporte. | |
MA40589A (fr) | Utilisation de jagged 1/frizzled 4 à titre de marqueurs de surface cellulaire pour isoler des cellules progénitrices ventriculaires cardiaques humaines | |
PH12018500371A1 (en) | Clinical formulations | |
MX2014014027A (es) | Modulacion por hutc de mediadores proinflamatorios de pulmon y enfermedades y trastornos pulmonares. | |
MX2019013614A (es) | Seleccion y uso de fracciones de celulas del cordon umbilical adecuadas para trasplante. | |
BR112013002811A8 (pt) | meios básicos simplificados para cultura celular pluripotente de humano | |
MX2015012729A (es) | Celulas discogenicas aisladas, metodos de uso y metodos de preparacion de las mismas a partir de tejido de mamiferos. | |
BR112017017886A2 (pt) | gerando populações de células endoteliais arteriais | |
WO2014186508A8 (en) | Human extensively self-renewing erythroblasts (esre) | |
MX2016005824A (es) | Metodo de cultivo celular. | |
MX2019013613A (es) | Seleccion y uso de fracciones de celulas del cordon umbilical adecuadas para trasplante. | |
WO2018009528A8 (en) | Combination cancer immunotherapies with arginine depletion agents | |
MX2020003314A (es) | Expansion y uso de fracciones de celulas nk ampliadas. | |
PH12016501689B1 (en) | Tatk-cdkl5 fusion proteins, compositions, formulations, and use thereof | |
WO2014140921A3 (en) | Cells, methods and apparatuses for umbilical cord blood collection and isolation of cells | |
WO2016019332A8 (en) | Method and apparatus for recovery of umbilical cord tissue derived regenerative cells and uses thereof |