MD970253A - Inhibitori biciclici micromoleculari ai trombinei - Google Patents
Inhibitori biciclici micromoleculari ai trombineiInfo
- Publication number
- MD970253A MD970253A MD97-0253A MD970253A MD970253A MD 970253 A MD970253 A MD 970253A MD 970253 A MD970253 A MD 970253A MD 970253 A MD970253 A MD 970253A
- Authority
- MD
- Moldova
- Prior art keywords
- low
- thrombin inhibitors
- thrombosis
- bicyclic
- molecular
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Abstract
Invenţia se referă la compuşi chimici noi care pot fi utilizaţi ca inhibitori competitivi ai enzimei de trombină.Sunt revendicaţi compuşii cu formula (I)metodele de tratament şi profilaxie a dereglărilor trombotice, cum este tromboza venelor, embolia pulmonară şi tromboza arterială, ce provoacă fenomene ischemice acute, cum este infarctul miocardic sau infarctul cerebral.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9426038.7A GB9426038D0 (en) | 1994-12-22 | 1994-12-22 | Low molecular weight bicyclic thrombin inhibitors |
GBGB9503136.5A GB9503136D0 (en) | 1994-12-22 | 1995-02-17 | Low molecular weight bicyclic thrombin inhibitors |
GBGB9510266.1A GB9510266D0 (en) | 1995-05-22 | 1995-05-22 | Low molecular weight bicyclic thrombin inhibitors |
GBGB9510267.9A GB9510267D0 (en) | 1995-05-22 | 1995-05-22 | Low molecular weight thiobicyclic thrombin inhibitors |
GBGB9510265.3A GB9510265D0 (en) | 1995-05-22 | 1995-05-22 | Low molecular weight diaminobicyclic thrombin inhibitors |
PCT/CA1995/000708 WO1996019483A1 (en) | 1994-12-22 | 1995-12-21 | Low molecular weight bicyclic thrombin inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MD970253A true MD970253A (ro) | 1999-05-31 |
Family
ID=27517273
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MD97-0253A MD970253A (ro) | 1994-12-22 | 1995-12-21 | Inhibitori biciclici micromoleculari ai trombinei |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP0802916A1 (ro) |
JP (1) | JPH11508535A (ro) |
CN (1) | CN1175259A (ro) |
AP (1) | AP9701004A0 (ro) |
AU (2) | AU4250596A (ro) |
BG (1) | BG101647A (ro) |
CA (1) | CA2208772A1 (ro) |
CZ (1) | CZ189997A3 (ro) |
EE (1) | EE9700113A (ro) |
FI (1) | FI972466A (ro) |
HU (1) | HUT77651A (ro) |
IL (1) | IL116503A0 (ro) |
IS (1) | IS4504A (ro) |
LV (1) | LV12019B (ro) |
MD (1) | MD970253A (ro) |
MX (1) | MX9704718A (ro) |
NO (1) | NO972892L (ro) |
NZ (1) | NZ297360A (ro) |
OA (1) | OA10493A (ro) |
PL (1) | PL320965A1 (ro) |
SK (1) | SK83897A3 (ro) |
WO (1) | WO1996019483A1 (ro) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6020331A (en) | 1995-03-24 | 2000-02-01 | Molecumetics, Ltd. | β-sheet mimetics and use thereof as protease inhibitors |
US6245764B1 (en) | 1995-03-24 | 2001-06-12 | Molecumetics Ltd. | β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins |
US6699869B1 (en) | 1995-03-24 | 2004-03-02 | Myriad Genetics Inc. | β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins |
IT1277405B1 (it) * | 1995-08-01 | 1997-11-10 | Menarini Farma Ind | Derivati di lattami biciclici come inibitori della trombina |
IL119466A (en) * | 1995-11-03 | 2001-08-26 | Akzo Nobel Nv | Thrombin inhibitors, their preparation and pharmaceutical compositions containing them |
CZ291690B6 (cs) * | 1996-02-13 | 2003-05-14 | Akzo Nobel N. V. | Inhibitory serinové proteázy a farmaceutický prostředek |
TW442452B (en) | 1996-03-01 | 2001-06-23 | Akzo Nobel Nv | Serine protease inhibitors having an alkynylamino side chain |
IL120311A (en) * | 1996-03-01 | 2001-10-31 | Akzo Nobel Nv | Serine protease inhibitors and pharmaceuticals containing them |
AU3232597A (en) * | 1996-06-18 | 1998-01-07 | Warner-Lambert Company | Pyrrolo{1,2-a}pyrazine-1,4-dione serine protease inhibitors |
EP1661566A3 (en) * | 1996-08-05 | 2008-04-16 | Myriad Genetics, Inc. | Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors |
US6117896A (en) | 1997-02-10 | 2000-09-12 | Molecumetics Ltd. | Methods for regulating transcription factors |
ES2262184T3 (es) * | 1996-08-05 | 2006-11-16 | Myriad Genetics, Inc. | Utilizacion de mimeticos de hojas beta como inhibidores de proteasa y de kinasa o como inhibidores de factores de transcripcion. |
AU4172397A (en) * | 1996-09-06 | 1998-03-26 | Biochem Pharma Inc. | Lactam inhibitors of thrombin |
US6262047B1 (en) | 1996-10-11 | 2001-07-17 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
US6369080B2 (en) | 1996-10-11 | 2002-04-09 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
US6194435B1 (en) | 1996-10-11 | 2001-02-27 | Cor Therapeutics, Inc. | Lactams as selective factor Xa inhibitors |
US6063794A (en) | 1996-10-11 | 2000-05-16 | Cor Therapeutics Inc. | Selective factor Xa inhibitors |
AU5526098A (en) * | 1996-12-23 | 1998-07-17 | Biochem Pharma Inc. | Bicyclic thrombin inhibitors |
CA2285659A1 (en) | 1997-04-14 | 1998-10-22 | Cor Therapeutics, Inc. | Selective factor xa inhibitors |
JP2001521524A (ja) * | 1997-04-14 | 2001-11-06 | シーオーアール セラピューティクス インコーポレイテッド | 選択的Xa因子阻害剤 |
WO1998046626A1 (en) | 1997-04-14 | 1998-10-22 | Cor Therapeutics, Inc. | SELECTIVE FACTOR Xa INHIBITORS |
US6218382B1 (en) | 1997-08-11 | 2001-04-17 | Cor Therapeutics, Inc | Selective factor Xa inhibitors |
US6333321B1 (en) | 1997-08-11 | 2001-12-25 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
US6228854B1 (en) | 1997-08-11 | 2001-05-08 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
AU740447B2 (en) * | 1997-09-23 | 2001-11-01 | Merck & Co., Inc. | Thrombin inhibitors |
JP2002503674A (ja) * | 1998-02-12 | 2002-02-05 | モレキュメティックス リミテッド | βシート模倣物およびその使用に関する方法 |
US6323219B1 (en) | 1998-04-02 | 2001-11-27 | Ortho-Mcneil Pharmaceutical, Inc. | Methods for treating immunomediated inflammatory disorders |
US8093293B2 (en) | 1998-07-06 | 2012-01-10 | Johnson & Johnson Consumer Companies, Inc. | Methods for treating skin conditions |
US8106094B2 (en) | 1998-07-06 | 2012-01-31 | Johnson & Johnson Consumer Companies, Inc. | Compositions and methods for treating skin conditions |
AU3127900A (en) | 1998-12-23 | 2000-07-31 | Du Pont Pharmaceuticals Company | Thrombin or factor xa inhibitors |
EP1147097A1 (en) | 1999-01-27 | 2001-10-24 | Ortho-Mcneil Pharmaceutical, Inc. | Peptidyl heterocyclic ketones useful as tryptase inhibitors |
FR2795072B1 (fr) * | 1999-06-15 | 2001-07-27 | Adir | Nouveaux derives bicycliques d'amino-pyrazinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
AU2001252958A1 (en) * | 2000-03-23 | 2001-10-03 | Elan Pharmaceuticals, Inc. | Compounds and methods to treat alzheimer's disease |
WO2002002519A2 (en) * | 2000-06-29 | 2002-01-10 | Bristol-Myers Squibb Pharma Company | THROMBIN OR FACTOR Xa INHIBITORS |
US8431550B2 (en) | 2000-10-27 | 2013-04-30 | Johnson & Johnson Consumer Companies, Inc. | Topical anti-cancer compositions and methods of use thereof |
FR2818277B1 (fr) * | 2000-12-14 | 2003-01-24 | Servier Lab | Nouveaux derives bicycliques d'amino-pyrazinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US7192615B2 (en) | 2001-02-28 | 2007-03-20 | J&J Consumer Companies, Inc. | Compositions containing legume products |
CA2476113A1 (en) | 2002-02-14 | 2003-08-21 | Myriad Genetics, Inc. | Beta-sheet mimetics and composition and methods relating thereto |
BR0308654A (pt) | 2002-03-22 | 2005-02-22 | Gpc Biotech Ag | Compostos imunossupressores, métodos e usos relacionados a eles |
RU2728785C2 (ru) | 2014-10-06 | 2020-07-31 | Кортексим, Инк. | Ингибиторы лизинспецифичного гингипаина |
JO3637B1 (ar) | 2015-04-28 | 2020-08-27 | Janssen Sciences Ireland Uc | مركبات بيرازولو- وترايازولو- بيريميدين مضادة للفيروسات rsv |
JP6877424B2 (ja) | 2015-11-09 | 2021-05-26 | コーテクシーミー, インコーポレイテッド | アルギニンジンジパインの阻害剤 |
TWI787202B (zh) | 2016-09-16 | 2022-12-21 | 美商昆斯治療公司 | 離胺酸牙齦蛋白酶(gingipain)之酮抑制劑 |
TW201932470A (zh) | 2017-11-29 | 2019-08-16 | 愛爾蘭商健生科學愛爾蘭無限公司 | 具有抗rsv活性之吡唑并嘧啶 |
EA202091835A1 (ru) | 2018-01-31 | 2020-10-20 | Янссен Сайенсиз Айрлэнд Анлимитед Компани | Замещенные циклоалкилом пиразолопиримидины, обладающие активностью против rsv |
ES2957316T3 (es) | 2018-04-23 | 2024-01-17 | Janssen Sciences Ireland Unlimited Co | Compuestos heteroaromáticos que tienen actividad contra VSR |
-
1995
- 1995-12-21 PL PL95320965A patent/PL320965A1/xx unknown
- 1995-12-21 CA CA002208772A patent/CA2208772A1/en not_active Abandoned
- 1995-12-21 SK SK838-97A patent/SK83897A3/sk unknown
- 1995-12-21 WO PCT/CA1995/000708 patent/WO1996019483A1/en not_active Application Discontinuation
- 1995-12-21 EP EP95940923A patent/EP0802916A1/en not_active Ceased
- 1995-12-21 CN CN95197614A patent/CN1175259A/zh active Pending
- 1995-12-21 AP APAP/P/1997/001004A patent/AP9701004A0/en unknown
- 1995-12-21 JP JP8519383A patent/JPH11508535A/ja active Pending
- 1995-12-21 AU AU42505/96A patent/AU4250596A/en not_active Abandoned
- 1995-12-21 MD MD97-0253A patent/MD970253A/ro unknown
- 1995-12-21 NZ NZ297360A patent/NZ297360A/xx unknown
- 1995-12-21 EE EE9700113A patent/EE9700113A/xx unknown
- 1995-12-21 HU HU9800216A patent/HUT77651A/hu unknown
- 1995-12-21 CZ CZ971899A patent/CZ189997A3/cs unknown
- 1995-12-22 IL IL11650395D patent/IL116503A0/xx unknown
- 1995-12-22 AU AU40628/95A patent/AU715378B2/en not_active Ceased
-
1997
- 1997-06-11 FI FI972466A patent/FI972466A/fi unknown
- 1997-06-11 IS IS4504A patent/IS4504A/is unknown
- 1997-06-18 OA OA70029A patent/OA10493A/en unknown
- 1997-06-20 NO NO972892A patent/NO972892L/no unknown
- 1997-06-20 BG BG101647A patent/BG101647A/xx unknown
- 1997-06-23 MX MX9704718A patent/MX9704718A/es unknown
- 1997-07-15 LV LVP-97-141A patent/LV12019B/en unknown
Also Published As
Publication number | Publication date |
---|---|
JPH11508535A (ja) | 1999-07-27 |
LV12019A (lv) | 1998-04-20 |
SK83897A3 (en) | 1998-05-06 |
PL320965A1 (en) | 1997-11-24 |
FI972466A (fi) | 1997-08-19 |
EP0802916A1 (en) | 1997-10-29 |
NZ297360A (en) | 2000-03-27 |
WO1996019483A1 (en) | 1996-06-27 |
CZ189997A3 (cs) | 1998-09-16 |
LV12019B (en) | 1998-07-20 |
OA10493A (en) | 2002-04-10 |
FI972466A0 (fi) | 1997-06-11 |
EE9700113A (et) | 1997-12-15 |
AP9701004A0 (en) | 1997-07-31 |
MX9704718A (es) | 1998-06-28 |
CN1175259A (zh) | 1998-03-04 |
AU4062895A (en) | 1996-07-04 |
BG101647A (en) | 1998-03-31 |
NO972892D0 (no) | 1997-06-20 |
AU715378B2 (en) | 2000-02-03 |
IL116503A0 (en) | 1996-03-31 |
AU4250596A (en) | 1996-07-10 |
CA2208772A1 (en) | 1996-06-27 |
NO972892L (no) | 1997-08-20 |
IS4504A (is) | 1997-06-11 |
HUT77651A (hu) | 1998-07-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PD99 | Pending application |