KR20210108781A - Weissella cibaria JSKIU 18-18 (KCTC18806P) from fermented local food in Jeju and composition with the function of anti-aging, anti-cancer and anti-dental caries thereof - Google Patents
Weissella cibaria JSKIU 18-18 (KCTC18806P) from fermented local food in Jeju and composition with the function of anti-aging, anti-cancer and anti-dental caries thereof Download PDFInfo
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Abstract
Description
본 발명은 와이셀라 사이베이라 JSKIU 18-18 (KCTC18806P) 및 이를 포함하는 조성물에 관한 것으로, 더욱 상세하게는 제주 토속 발효식품으로부터 분리한 와이셀라 사이베이라 JSKIU 18-18 (KCTC18806P) 및 이를 포함하는 항노화, 항암, 항충치 효능이 있는 조성물에 관한 것이다. The present invention relates to Wasella cybeira JSKIU 18-18 (KCTC18806P) and a composition comprising the same, and more particularly, to Wasella cybeira JSKIU 18-18 (KCTC18806P) isolated from Jeju native fermented food and antibiotics containing the same It relates to a composition having anti-aging, anti-cancer, and anti-cavity effects.
유산균(lactic acid bacteria)은 통성 혐기성균 또는 편성 혐기성균인데, 탄수화물을 대사하여 젖산(lactic acid)를 생산한다. 유산균은 장내 pH를 산성으로 유지시켜 유해균의 번식을 억제하고 설사와 변비를 개선할 뿐 아니라, 비타민 합성, 면역증진작용, 항암작용, 혈청 콜레스테롤 저하 등의 역할을 하는 것을 보고되어 있다.Lactic acid bacteria are facultative anaerobes or obligate anaerobes, which metabolize carbohydrates to produce lactic acid. It has been reported that lactic acid bacteria maintain intestinal pH in an acidic manner to suppress the reproduction of harmful bacteria and improve diarrhea and constipation, as well as play a role in vitamin synthesis, immune enhancement, anticancer action, and lowering serum cholesterol.
유산균에는 락토바실러스(Lactobacillus), 스트렙토코커스(Streptococcus), 루코노스탁(Leuconostoc), 비피도박테리아(Bifidobacteria), 페디오코커스(Pediococcus) 등이 있는데, 락토바실러스는 그 중 가장 많이 연구가 되어 있는 유산균이다.Lactic acid bacteria are Lactobacillus bacteria (Lactobacillus), Streptococcus (Streptococcus), Lou Pocono Stark (Leuconostoc), bifidobacteria bacteria (Bifidobacteria), Peddie Oh caucus there are such (Pediococcus), Lactobacillus is a lactic acid bacterium that is the most studied of them am.
와이셀라 사이베이라(Weissella cibaria) 균은 그림양성의 유산균이며, 김치의 상쾌한 맛에 영향을 주는 유익균이다. 또한, 사람 또는 동물의 면역증강, 항 비만 활성, 암의 예방 및 개선 또는 치료, 아토피 피부염 등에 효과가 있는 것으로 알려져 있다. Weissella cibaria is a picture-positive lactic acid bacterium, and is a beneficial bacterium that affects the refreshing taste of kimchi. In addition, it is known to be effective in enhancing human or animal immunity, anti-obesity activity, preventing and improving or treating cancer, atopic dermatitis, and the like.
한편, 와이셀라 사이베이라(Weissella cibaria)는 다른 유산균 종에 비해 그리 많이 연구된 수준의 균은 아니다. On the other hand, Weissella cibaria is not a very well-studied level of bacteria compared to other lactic acid bacteria species.
본 발명에서는 우수한 항노화, 항암, 항충치 효능을 갖는 신규의 와이셀라 사이베이라(Weissella cibaria)을 분리하여 제공하고, 이를 조성물로 개발하여 제공하고자 한다. In the present invention, a novel Weissella cibaria having excellent anti-aging, anti-cancer, and anti-caries efficacy is separated and provided, and it is to be developed and provided as a composition.
본 발명은 와이셀라 사이베이라(Weissella cibaria) JSKIU 18-18 (KCTC18806P) 균주를 제공한다.The present invention provides a strain of Weissella cibaria JSKIU 18-18 (KCTC18806P).
본 발명은 와이셀라 사이베이라(Weissella cibaria) JSKIU 18-18 (KCTC18806P) 균주 또는 이의 배양액을 포함하는 프로바이오틱스(probiotics)를 제공한다. The present invention provides a probiotics (probiotics) comprising a Weissella cibaria JSKIU 18-18 (KCTC18806P) strain or a culture thereof.
또한, 본 발명은 와이셀라 사이베이라(Weissella cibaria) JSKIU 18-18 (KCTC18806P) 균주 또는 이의 배양액을 포함하는 것을 특징으로 하는 식품 조성물을 제공한다. In addition, the present invention provides a food composition comprising a Weissella cibaria JSKIU 18-18 (KCTC18806P) strain or a culture solution thereof.
또한, 본 발명의 식품 조성물에 있어서, 상기 식품 조성물은, 바람직하게 노화 억제용, 암 발생 억제용 및 충치 억제용 중 선택되는 어느 하나일 수 있다.In addition, in the food composition of the present invention, the food composition may preferably be any one selected from among anti-aging, cancer-inhibiting, and caries-inhibiting.
한편, 본 발명은 와이셀라 사이베이라(Weissella cibaria) JSKIU 18-18 (KCTC18806P) 균주 또는 이의 배양액을 포함하는 것을 특징으로 하는 화장료 조성물을 제공한다. On the other hand, the present invention provides a cosmetic composition comprising a Weissella cibaria JSKIU 18-18 (KCTC18806P) strain or a culture solution thereof.
또한, 상기 본 발명의 화장료 조성물에 있어서, 상기 화장료 조성물은 바람직하게 노화방지용 화장료 조성물일 수 있다. In addition, in the cosmetic composition of the present invention, the cosmetic composition may preferably be an anti-aging cosmetic composition.
한편, 본 발명은 와이셀라 사이베이라(Weissella cibaria) JSKIU 18-18 (KCTC18806P) 균주 또는 이의 배양액을 포함하는 것을 특징으로 하는 치약 조성물을 제공한다. On the other hand, the present invention provides a toothpaste composition comprising a Weissella cibaria JSKIU 18-18 (KCTC18806P) strain or a culture solution thereof.
본 발명의 와이셀라 사이베이라(Weissella cibaria) JSKIU 18-18 (KCTC18806P) 균주는 우수한 노화 억제, 암 발생 억제 또는 충치 억제 효과를 발휘하는 바, 식품, 의약품, 화장품, 치약 조성물로 사용될 수 있다. Weissella cibaria ( Weissella cibaria ) JSKIU 18-18 (KCTC18806P) strain of the present invention exhibits excellent anti-aging, cancer-generating or caries suppression effects, and can be used as a food, pharmaceutical, cosmetic, or toothpaste composition.
도 1은 본 발명 와이셀라 사이베이라(Weissella cibaria) JSKIU 18-18 균주의 항산화능 측정 결과이다.
도 2는 본 발명 와이셀라 사이베이라(Weissella cibaria) JSKIU 18-18 균주의 항암능 측정 결과이다.
도 3은 본 발명 와이셀라 사이베이라(Weissella cibaria) JSKIU 18-18 균주의 항충치능 측정 결과이다.1 is a measurement result of the antioxidant capacity of the present invention Weissella cibaria JSKIU 18-18 strain.
2 is a measurement result of the anticancer activity of the present invention Weissella cibaria JSKIU 18-18 strain.
Figure 3 is the present invention Weissella cibaria ( Weissella cibaria ) JSKIU 18-18 strain of the anti-cavity performance measurement results.
본 발명은 와이셀라 사이베이라(Weissella cibaria) JSKIU 18-18 (KCTC18806P) 균주를 제공한다.The present invention provides a strain of Weissella cibaria JSKIU 18-18 (KCTC18806P).
본 발명의 와이셀라 사이베이라(Weissella cibaria) JSKIU 18-18는 제주 토속 발효식품인 멸치액젓으로부터 분리된 균주이다. 본 발명의 균주는, 하기 실험에 의할 경우, 항산화 효능이 있는 것으로 확인되었다. 항산화능이 확인되어, 본 발명의 균주는 노화 억제용 식품 조성물로 사용될 수 있다. 또한, 본 발명의 균주는, 하기 실험에 의할 경우, 암 발생 억제 효능이 있는 것으로 확인되었다. 이로부터 본 발명의 균주는 암 발생 억제용 식품 조성물로 사용될 수 있다. 또한, 본 발명의 균주는, 하기 실험에 의할 경우, 충치 발생 균주인 스트렙토코쿠스 뮤탄스 (Streptococcus mutans)의 생육을 억제하는 효능이 있는 것으로 확인되었다. The Weissella cibaria JSKIU 18-18 of the present invention is a strain isolated from anchovy fish sauce, a fermented food native to Jeju. The strain of the present invention, according to the following experiment, was confirmed to have an antioxidant effect. Antioxidant ability is confirmed, the strain of the present invention can be used as a food composition for inhibiting aging. In addition, the strain of the present invention, according to the following experiment, it was confirmed that there is a cancer-inhibiting effect. From this, the strain of the present invention can be used as a food composition for inhibiting cancer occurrence. In addition, the strain of the present invention, according to the following experiment, Streptococcus mutans ( Streptococcus mutans ) It was confirmed that there is an effect of inhibiting the growth of tooth decay.
한편, 본 발명은 와이셀라 사이베이라(Weissella cibaria) JSKIU 18-18 (KCTC18806P) 균주 또는 이의 배양액을 포함하는 프로바이오틱스(probiotics)를 제공한다.On the other hand, the present invention provides a probiotics (probiotics) comprising a Weissella cibaria JSKIU 18-18 (KCTC18806P) strain or a culture solution thereof.
프로바이오틱스는 생균제를 의미하는 것으로 본 발명의 균주 또는 이의 배양액은 생균제 형태로 제품화되어 사용될 수 있다. 다만, 생균제로의 제형화를 위해 본 발명의 균주 또는 이의 배양액 외에 여러 보조제 예를 들어 감미제, 안정제 등을 첨가할 수 있다. Probiotics refer to probiotics, and the strain of the present invention or a culture solution thereof may be commercialized and used in the form of probiotics. However, in addition to the strain of the present invention or a culture solution thereof, various auxiliary agents, for example, a sweetener, a stabilizer, etc. may be added for formulation into a probiotic.
또한, 본 발명에서 배양액이란, 공지의 액체 배지 또는 고체 배지에 본 발명 와이셀라 사이베이라(Weissella cibaria) JSKIU 18-18 균주를 일정기간 배양하여 얻는 배양된 균주의 배양액을 의미하며, 배지 조성까지를 포함할 수 있다.In addition, in the present invention, the culture medium means a culture medium of the cultured strain obtained by culturing the present invention Weissella cibaria JSKIU 18-18 strain in a known liquid medium or solid medium for a certain period of time, up to the medium composition may include
한편, 와이셀라 사이베이라(Weissella cibaria) JSKIU 18-18 (KCTC18806P) 균주를 포함하는 것을 특징으로 하는 식품 조성물을 제공한다.On the other hand, Weissella cibaria provides a food composition comprising a strain JSKIU 18-18 (KCTC18806P).
본 발명에 있어서, 상기 식품 조성물은 특정의 제형에 반드시 한정되는 것은 아니고, 일 예로 캡슐, 정제, 분말, 과립, 액상, 환, 편상, 페이스트상, 시럽, 겔, 젤리 또는 바(bar) 형태로 제제화한 것일 수 있다. 또한, 음료, 차류, 향신료, 껌, 과자류 등의 식품소재에 첨가하여 일반 식품 형태로 제조한 것일 수 있다. In the present invention, the food composition is not necessarily limited to a specific formulation, for example, in the form of capsules, tablets, powders, granules, liquids, pills, flakes, pastes, syrups, gels, jellies or bars. It may be formulated. In addition, it may be prepared in the form of a general food by adding it to food materials such as beverages, teas, spices, gum, and confectionery.
또한, 본 발명의 식품 조성물에 있어, 와이셀라 사이베이라(Weissella cibaria) JSKIU 18-18 균주 또는 이의 배양액 첨가량은, 대상인 식품의 종류에 따라 다양하게 첨가할 수 있다. 통상적으로 식품 본래의 맛을 손상시키지 않는 범위에서 첨가하면 되고, 통상 0.01 내지 50 중량%, 바람직하기로는 0.1 내지 20 중량%의 범위 내에서 첨가할 수 있다. In addition, in the food composition of the present invention, the amount of Weissella cibaria JSKIU 18-18 strain or its culture solution added may be variously added according to the type of target food. In general, it may be added in a range that does not impair the original taste of the food, and is usually 0.01 to 50% by weight, preferably 0.1 to 20% by weight.
또한, 본 발명의 식품 조성물은, 식품에 통상적으로 첨가되는 보조성분을 포함할 수 있으며, 예를 들어, 단백질, 탄수화물, 지방, 영양소, 조미제 및 향미제 등을 포함할 수 있다. In addition, the food composition of the present invention may include auxiliary components commonly added to food, for example, proteins, carbohydrates, fats, nutrients, seasonings and flavoring agents, and the like.
또한, 본 발명의 식품 조성물은 노화 억제용 식품 조성물일 수 있고, 암 발생 억제용 식품 조성물일 수 있으며, 충치 억제용 식품 조성물일 수 있다. 이때, 상기 '억제'의 의미는 '방지'를 포함하는 의미로 해석될 수 있다. In addition, the food composition of the present invention may be a food composition for inhibiting aging, may be a food composition for inhibiting cancer occurrence, and may be a food composition for inhibiting tooth decay. In this case, the meaning of 'suppression' may be interpreted as meaning including 'prevention'.
한편, 본 발명의 와이셀라 사이베이라(Weissella cibaria) JSKIU 18-18 (KCTC18806P) 균주 또는 이의 배양액을 포함하는 것을 특징으로 하는 약품조성물을 제공한다. 이때, 상기 약품 조성물은 노화 예방용 또는 치료용 약품 조성물일 수 있고, 암 예방 또는 치료용 약품 조성물일 수 있으며, 충치 예방 또는 치료용 약품 조성물일 수 있다.On the other hand, Weissella cibaria of the present invention provides a pharmaceutical composition comprising a strain or a culture solution thereof JSKIU 18-18 (KCTC18806P). In this case, the pharmaceutical composition may be a pharmaceutical composition for preventing or treating aging, a pharmaceutical composition for preventing or treating cancer, or a pharmaceutical composition for preventing or treating tooth decay.
한편, 본 발명은 와이셀라 사이베이라(Weissella cibaria) JSKIU 18-18 (KCTC18806P) 균주 또는 이의 배양액을 포함하는 것을 특징으로 하는 화장료 조성물을 제공한다. 이때, 상기 화장료 조성물은 바람직하게 노화방지용 화장료 조성물일 수 있다. On the other hand, the present invention provides a cosmetic composition comprising a Weissella cibaria JSKIU 18-18 (KCTC18806P) strain or a culture solution thereof. In this case, the cosmetic composition may preferably be an anti-aging cosmetic composition.
또한, 본 발명의 화장료 조성물은 상기 본 발명의 와이셀라 사이베이라(Weissella cibaria) JSKIU 18-18 (KCTC18806P) 균주 또는 배양액 외에 여러 보조적 성분을 첨가하여 제조될 수 있고, 당업계에서 통상적으로 제조되는 어떠한 제형으로도 제조될 수 있다. In addition, the cosmetic composition of the present invention can be prepared by adding various auxiliary components in addition to the Weissella cibaria JSKIU 18-18 (KCTC18806P) strain or culture solution of the present invention, and any conventionally prepared in the art. Formulations can also be prepared.
보조적 성분으로는 제품의 부패를 방지하는 방부제, 안정제 등이 사용될 수 있다. 제형의 예로는 화장수, 젤, 수용성 리퀴드, 크림, 에센스, 수중유(O/W)형 및 유중수(W/O)형으로 이루어진 기초화장료 제형과, 수중유형 및 유중수형 메이크업베이스, 파운데이션, 스킨커버, 립스틱, 립그로스, 페이스파우더, 투웨이케익, 아이섀도, 치크칼라 및 아이브로우 펜슬류로 이루어진 색조화장료 제형과 바디로션, 바디오일, 바디에센스, 바디팩 등 바디용 제형 중에서 선택되는 어느 하나일 수 있다. As auxiliary ingredients, preservatives and stabilizers that prevent product spoilage may be used. Examples of the formulation include a basic cosmetic formulation consisting of lotion, gel, water-soluble liquid, cream, essence, oil-in-water (O/W) type and water-in-oil (W/O) type, oil-in-water and water-in-oil type makeup base, foundation, skin Any one selected from color cosmetics formulations consisting of cover, lipstick, lip gloss, face powder, two-way cake, eye shadow, cheek color, and eyebrow pencils, and body formulations such as body lotion, body oil, body essence, and body pack. can
한편, 본 발명은 와이셀라 사이베이라(Weissella cibaria) JSKIU 18-18 (KCTC18806P) 균주 또는 이의 배양액을 포함하는 것을 특징으로 하는 치약 조성물을 제공한다. On the other hand, the present invention provides a toothpaste composition comprising a Weissella cibaria JSKIU 18-18 (KCTC18806P) strain or a culture solution thereof.
하기 본 발명에 의할 경우, 본 발명은 와이셀라 사이베이라(Weissella cibaria) JSKIU 18-18 (KCTC18806P) 균주의 충치 발생균인 스트렙토코쿠스 뮤탄스 (Streptococcus mutans)에 대한 생육 억제능이 확인 바, 치약 조성물의 유효성분으로 사용될 수 있고, 본 발명 와이셀라 사이베이라(Weissella cibaria) JSKIU 18-18 (KCTC18806P) 균주 또는 이의 배양액이 첨가된 치약은 충치예방 효과를 발휘할 수 있다. According to the present invention, the present invention is Weissella cibaria JSKIU 18-18 (KCTC18806P) Streptococcus mutans , a caries-inducing bacteria of the strain Streptococcus mutans Growth inhibitory ability is confirmed bar, toothpaste It can be used as an active ingredient of the composition, and the present invention Weissella cibaria JSKIU 18-18 (KCTC18806P) strain or a toothpaste to which a culture solution thereof is added can exert a caries prevention effect.
또한, 본 발명에 따른 치약 조성물은 본 발명의 와이셀라 사이베이라(Weissella cibaria) JSKIU 18-18 (KCTC18806P) 균주 외에 습윤제, 점도조절제, 감미제, 보존제, 기포제, 착향제, 착색제 및 용제로 이루어진 군으로부터 선택되는 부성분을 포함할 수 있다. In addition, the toothpaste composition according to the present invention is a Weissella cibaria JSKIU 18-18 (KCTC18806P) strain of the present invention, in addition to a wetting agent, a viscosity modifier, a sweetener, a preservative, a foaming agent, a flavoring agent, a coloring agent and a solvent from the group consisting of It may include selected sub-ingredients.
이하, 본 발명의 내용에 대해 하기 실시예 및 실험예를 통해 더욱 상세히 설명하고자 한다. 다만, 본 발명의 권리범위가 하기 실시예 및 실험예에 한정되는 것은 아니고, 그와 등가의 기술적 사상의 변형까지를 포함한다.Hereinafter, the content of the present invention will be described in more detail through the following examples and experimental examples. However, the scope of the present invention is not limited to the following examples and experimental examples, and includes modifications of technical ideas equivalent thereto.
[실시예 1: 본 발명 와이셀라 사이베이라([Example 1: Weissella cybeira of the present invention ( Weissella cibariaWeissella cibaria ) JSKIU 18-18 균주의 분리]) Isolation of JSKIU 18-18 strain]
본 발명에서는 제주 토속 발효식품인 멸치액젓으로부터 와이셀라 사이베이라 균주를 분리한 후, JSKIU 18-18로 명명하고, 한국생명공학연구원에 2020년 2월 25일자로 기탁하여 기탁번호 KCTC18806P를 부여받았다.In the present invention, the Wasella cybeira strain was isolated from the anchovy fish sauce, a fermented food native to Jeju, and named as JSKIU 18-18.
이하에서는 본 발명 균주 와이셀라 사이베이라(Weissella cibaria) JSKIU 18-18의 항산화능, 항암능 및 항충치능을 확인하였다.Hereinafter, the antioxidant activity, anticancer activity and anti-caries activity of the present invention strain Weissella cibaria JSKIU 18-18 was confirmed.
[실험예 1: 본 발명 와이셀라 사이베이라([Experimental Example 1: The present invention Wasella cybeira ( Weissella cibariaWeissella cibaria ) JSKIU 18-18 균주의 항산화능 측정]) Measurement of antioxidant activity of JSKIU 18-18 strain]
본 실험예에서는 와이셀라 사이베이라(Weissella cibaria) JSKIU 18-18 균주의 항산화능을 측정하고자 하였다.In this experimental example, the antioxidant capacity of Weissella cibaria JSKIU 18-18 strain was measured.
물리적으로 분쇄한 브로콜리액에 균주 Weissella cibaria JSKIU 18-18를 접종하고, 37℃에서 72시간 동안 발효하여 실험군 샘플을 준비하였다. 이때, 음성대조군으로는 물리적으로 분쇄한 브로콜리액을 사용하였다. The strain Weissella cibaria JSKIU 18-18 was inoculated into the physically pulverized broccoli liquid, and fermented at 37° C. for 72 hours to prepare an experimental group sample. In this case, as a negative control, physically crushed broccoli solution was used.
항산화능은 "Donghong Liu, John Shib, Alejandra Colina Ibarrac, Yukio Kakudac, SophiaJun Xueb, The scavenging capacity and synergistic effects of lycopene, vitamin E, vitamin C, and β-carotene mixtures on the DPPH free radical, LWT 41 (2008) 1344-1349" 문헌을 참조하여 측정하였다. Antioxidant activity was described in "Donghong Liu, John Shib, Alejandra Colina Ibarrac, Yukio Kakudac, SophiaJun Xueb, The scavenging capacity and synergistic effects of lycopene, vitamin E, vitamin C, and β-carotene mixtures on the DPPH free radical , LWT 41 (2008) ) 1344-1349" with reference to the literature.
그 결과는 도 1과 같았다. 도 1에서 보는 바와 같이, 50배, 100배 희석하였을 때, 실험군이 음성대조군보다 높은 항산화능을 보이는 것을 확인할 수 있었다. 이와 같은 결과로부터 본 발명의 균주에 항산화 활성이 있는 것으로 결론내릴 수 있었다. The result was as shown in FIG. 1 . As shown in FIG. 1, when diluted 50-fold and 100-fold, it was confirmed that the experimental group showed higher antioxidant activity than the negative control group. From these results, it could be concluded that the strain of the present invention has antioxidant activity.
[실험예 2: 본 발명 와이셀라 사이베이라([Experimental Example 2: The present invention Wasella cybeira ( Weissella cibariaWeissella cibaria ) JSKIU 18-18 균주의 항암능 측정]) Measurement of anticancer activity of JSKIU 18-18 strain]
본 실험예에서는 와이셀라 사이베이라(Weissella cibaria) JSKIU 18-18 균주의 항암능을 측정하고자 하였다.In this experimental example, the anticancer activity of the Weissella cibaria JSKIU 18-18 strain was measured.
물리적으로 분쇄한 브로콜리액에 균주 Weissella cibaria JSKIU 18-18를 접종하고, 37℃에서 72시간 동안 발효하여 실험군 샘플을 준비하였다. 이때, 음성대조군으로는 물리적으로 분쇄한 브로콜리액을 사용하였다. The strain Weissella cibaria JSKIU 18-18 was inoculated into physically pulverized broccoli liquid, and fermented at 37° C. for 72 hours to prepare an experimental group sample. In this case, as a negative control, physically crushed broccoli solution was used.
항암능은 MTT assay를 통해 측정하였는데, "Joon-Ho Hwang, Sang-Bin Lim, Antioxidant and Anticancer Activities of Broccoli By-Products from Different Cultivars and Maturity Stages at Harvest, Department of Biology, Biotechnology Regional Innovation Center, and Department of Food Bioengineering, Nutr. Food Sci. 2015;20(1):8-14"의 방법을 참조하여 측정하였다. Anticancer activity was measured by MTT assay, "Joon-Ho Hwang, Sang-Bin Lim, Antioxidant and Anticancer Activities of Broccoli By-Products from Different Cultivars and Maturity Stages at Harvest, Department of Biology, Biotechnology Regional Innovation Center, and Department of Food Bioengineering, Nutr. Food Sci. 2015;20(1):8-14".
그 결과는 도 2와 같았다. 도 2에서 보는 바와 같이, 실험군이 음성대조군보다 높은 cell growth inhibitory activity (암세포 성장 억제 활성)를 나타냄을 확인할 수 있었다. 이와 같은 결과로부터 본 발명의 균주에 항암 활성이 있는 것으로 결론내릴 수 있었다. The result was as shown in FIG. 2 . As shown in FIG. 2 , it was confirmed that the experimental group exhibited higher cell growth inhibitory activity (cancer cell growth inhibitory activity) than the negative control group. From these results, it could be concluded that the strain of the present invention has anticancer activity.
[실험예 3: 본 발명 와이셀라 사이베이라([Experimental Example 3: The present invention Wasella cybeira ( Weissella cibariaWeissella cibaria ) JSKIU 18-18 균주의 항충치능 측정]) Measurement of anti-cavity activity of JSKIU 18-18 strain]
본 실험예에서는 와이셀라 사이베이라(Weissella cibaria) JSKIU 18-18 균주의 항충치능을 측정하고자 하였다.In this experimental example, Weissella cibaria was intended to measure the anti-caries activity of JSKIU 18-18 strain.
물리적으로 분쇄한 브로콜리액에 균주 Weissella cibaria JSKIU 18-18를 접종하고,37℃에서 72시간 동안 발효하여 실험군 샘플을 준비하였다. 이때, 음성대조군으로는 물리적으로 분쇄한 브로콜리액을 사용하였다. The strain Weissella cibaria JSKIU 18-18 was inoculated into the physically pulverized broccoli solution, and fermented at 37° C. for 72 hours to prepare an experimental group sample. In this case, as a negative control, physically crushed broccoli solution was used.
이상에서 준비한 샘플을 가지고 충치균인 스트렙토코쿠스 뮤탄스 (Streptococcus mutans)의 증식 억제능을 확인하였다. 상기의 샘플이 혼합된 배지에 스트렙토코쿠스 뮤탄스 (Streptococcus mutans)를 도말하고 3일 동안 정치배양하여 스트렙토코쿠스 뮤탄스 (Streptococcus mutans)의 생육 억제능을 측정하였다. 그 결과는 도 3과 같이 나타났다. 도 3에서 보는 바와 같이, 3일 경과 후, 실험군은 스트렙토코쿠스 뮤탄스 (Streptococcus mutans)의 생육을 완전히 억제하는 것으로 나타났다. 이에 반해 음성대조군에서는 스트렙토코쿠스 뮤탄스 (Streptococcus mutans)의 생육이 약 18.5 log(CFU) 값 정도로 나타났다. 이와 같은 결과로부터 본 발명의 균주에 항충치 활성이 있는 것으로 결론내릴 수 있었다. With the sample prepared above, the growth inhibitory ability of Streptococcus mutans, a caries bacterium, was confirmed. Streptococcus mutans was smeared on the medium in which the above samples were mixed, and the culture was stationary for 3 days to measure the growth inhibitory ability of Streptococcus mutans. The results were shown in FIG. 3 . As shown in FIG. 3 , after 3 days, the experimental group completely inhibited the growth of Streptococcus mutans. In contrast, in the negative control group, the growth of Streptococcus mutans was about 18.5 log(CFU) value. From these results, it could be concluded that the strain of the present invention has anti-caries activity.
기탁기관명 : 한국생명공학연구원Name of deposit institution: Korea Research Institute of Bioscience and Biotechnology
수탁번호 : KCTC18806PAccession number: KCTC18806P
수탁일자 : 20200225Deposit date: 20200225
Claims (7)
Weissella cibaria JSKIU 18-18 strain (KCTC18806P).
Weissella cibaria ( Weissella cibaria ) JSKIU 18-18 (KCTC18806P) strain or probiotics containing a culture solution thereof (probiotics).
Weissella cibaria ( Weissella cibaria ) JSKIU 18-18 (KCTC18806P) food composition comprising a strain or a culture solution thereof.
상기 식품 조성물은,
노화 억제용, 암 발생 억제용 및 충치 억제용 중 선택되는 어느 하나인 것을 특징으로 하는 식품 조성물.
4. The method of claim 3,
The food composition,
A food composition, characterized in that any one selected from the group consisting of inhibiting aging, inhibiting cancer occurrence, and inhibiting caries.
Weissella cibaria ( Weissella cibaria ) JSKIU 18-18 (KCTC18806P) A cosmetic composition comprising a strain or a culture solution thereof.
상기 화장료 조성물은,
노화방지용 화장료 조성물인 것을 특징으로 하는 화장료 조성물.
6. The method of claim 5,
The cosmetic composition,
A cosmetic composition, characterized in that it is an anti-aging cosmetic composition.
Weissella cybaria ( Weissella cibaria ) JSKIU 18-18 (KCTC18806P) strain or a toothpaste composition comprising a culture solution thereof.
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| 대한민국 특허공개번호 제1020150031922호(공개일자 2015.03.25)에는,면역 증강 활성이 있는 배양물을 생산하는 와이셀라 시바리아(Weissella cibaria) JW15 KACC91811P 균주, 유효성분으로 포함하는 면역질환의 예방 또는 치료용 약학적 조성물, 식품, 정장용 조성물, 생균제, 사료용 조성물, 발효제품으로 사용될 수 있는 와이셀라 시바리아(Weissella cibaria) JW15 KACC91811P 균주가 기재되어 있다. |
| 대한민국 특허공개번호 제1020180059728호 (공개일자 2018.06.05)에는, 김치에서 분리한 신규 유산균 균주로, 항진균 및 항세균활성을 갖는 와이셀라 시바리아 (Weissella cibaria) AB160066 가 기재되어 있다. |
| 대한민국 특허등록번호 제1018343830000호 (등록번호 2018.02.26)에는, 항비만 활성을 갖는 프로바이오틱스로서, 사람 또는 동물의 비만 예방 및 개선, 정장 등의 용도로 와이셀라 시바리아(Weissella cibaria) WIKIM28 가 기재되어 있다. |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113930367A (en) * | 2021-11-12 | 2022-01-14 | 湖北安琪生物集团有限公司 | Lactic acid bacteria with cholesterol-reducing performance and application thereof |
| CN113930367B (en) * | 2021-11-12 | 2023-11-14 | 安琪生物科技有限公司 | Lactic acid bacteria with cholesterol reducing performance and application thereof |
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