JPS63198612A - Trichogenous hair-growing agent - Google Patents
Trichogenous hair-growing agentInfo
- Publication number
- JPS63198612A JPS63198612A JP62031250A JP3125087A JPS63198612A JP S63198612 A JPS63198612 A JP S63198612A JP 62031250 A JP62031250 A JP 62031250A JP 3125087 A JP3125087 A JP 3125087A JP S63198612 A JPS63198612 A JP S63198612A
- Authority
- JP
- Japan
- Prior art keywords
- hair
- growing agent
- extract
- water
- trichogenous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 10
- 239000003960 organic solvent Substances 0.000 claims abstract description 5
- 229930185597 Euphorbia lathyris Natural products 0.000 claims abstract 2
- 241001553700 Euphorbia lathyris Species 0.000 claims abstract 2
- 230000003779 hair growth Effects 0.000 claims description 13
- 241000411851 herbal medicine Species 0.000 claims description 9
- 230000001737 promoting effect Effects 0.000 claims description 5
- 239000004480 active ingredient Substances 0.000 claims description 3
- 241000865486 Knoxia Species 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000000284 extract Substances 0.000 abstract description 23
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 20
- 239000003814 drug Substances 0.000 abstract description 14
- 229940079593 drug Drugs 0.000 abstract description 13
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract description 6
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract description 4
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract description 3
- 239000000203 mixture Substances 0.000 abstract description 3
- 239000002904 solvent Substances 0.000 abstract description 3
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 abstract description 2
- 201000004624 Dermatitis Diseases 0.000 abstract description 2
- 240000007110 Knoxia sumatrensis Species 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- 238000010792 warming Methods 0.000 abstract 1
- 210000004209 hair Anatomy 0.000 description 18
- 239000008213 purified water Substances 0.000 description 6
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 4
- 239000003995 emulsifying agent Substances 0.000 description 4
- -1 propatool Chemical compound 0.000 description 4
- 201000004384 Alopecia Diseases 0.000 description 3
- 240000003183 Manihot esculenta Species 0.000 description 3
- 235000016735 Manihot esculenta subsp esculenta Nutrition 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 208000024963 hair loss Diseases 0.000 description 3
- 230000003676 hair loss Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 2
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- 229930003427 Vitamin E Natural products 0.000 description 2
- 208000004631 alopecia areata Diseases 0.000 description 2
- 229960000541 cetyl alcohol Drugs 0.000 description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
- 229940041616 menthol Drugs 0.000 description 2
- 239000004200 microcrystalline wax Substances 0.000 description 2
- 235000019808 microcrystalline wax Nutrition 0.000 description 2
- 239000012188 paraffin wax Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 229940099259 vaseline Drugs 0.000 description 2
- 229940046009 vitamin E Drugs 0.000 description 2
- 235000019165 vitamin E Nutrition 0.000 description 2
- 239000011709 vitamin E Substances 0.000 description 2
- 206010040880 Skin irritation Diseases 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000012676 herbal extract Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000003808 methanol extraction Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000001936 parietal effect Effects 0.000 description 1
- 150000003138 primary alcohols Chemical class 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000037380 skin damage Effects 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
Abstract
Description
【発明の詳細な説明】
本発明は新規な発毛・青毛促進料に関するものであり、
皮膚刺激のない安全なものである。[Detailed description of the invention] The present invention relates to a novel hair growth/green hair promoting agent,
It is safe and does not cause skin irritation.
従来、発毛・青毛促進料には各種の化合物、生薬等の抽
出エキス等が適用されているが、顕著な効果を示すもの
は殆んどなく、またある程度効果を有するものは皮膚炎
を起す程刺激が強く連続使用が困難である等の欠点があ
ったが、本発明者は種々実験研究の結果、このような欠
点のない本発明を得たのである。Conventionally, various compounds and extracts of crude drugs have been used to promote hair growth and blue hair, but few of them have shown significant effects, and those that have some effect may cause dermatitis. However, as a result of various experimental studies, the present inventors have developed the present invention which does not have these drawbacks.
本発明は、続随子または大戦の生薬から水溶性分ｎ溶媒
単独またはこれらの含水有機溶媒により抽出した有効成
分を一種または二種含有することを特徴とする発毛・青
毛促進料に関するものである。The present invention relates to a hair growth/blue hair promoting agent characterized by containing one or two types of active ingredients extracted from a water-soluble component or a water-containing organic solvent from a herbal medicine such as Setsujizi or Great War. be.
本発明に適用される発毛・青毛促進料を得る方法として
は、続随子または大戦の生薬１００９を、例えばメタノ
ール、エタノール、プロパツール、ブタノール等の一級
アルコール、またはアセトン、テラヒドロフラン、ジオ
キサンの有機溶媒単独、または前記−級アルコールまた
はアセトン、テトラヒドロフラン、ジオキサンを５０重
但％以上含有する含水有機溶［１，＋＋で２時間づつ３
回温浸抽出する。これら抽出エキスを合わせ、吸引口過
後、溶媒を除く為減圧上濃縮乾固し、粘稠状の生薬エキ
スを得る。得られた生薬エキスをそのまま、あるいは適
宜の溶媒等で溶解分散希釈せしめ基剤中に配合し本発明
の発毛・青毛促進料を得る。As a method for obtaining the hair growth/blue hair promoter applied to the present invention, the herbal medicine 1009 of Seizou or Taisen is mixed with a primary alcohol such as methanol, ethanol, propatool, butanol, or acetone, terahydrofuran, dioxane, etc. alone, or a water-containing organic solution containing 50 wt.
Extract by double soaking. These extracted extracts are combined, passed through a suction port, and concentrated to dryness under reduced pressure to remove the solvent to obtain a viscous crude drug extract. The obtained crude drug extract is used as it is, or is dissolved and dispersed in a suitable solvent, diluted, and blended into a base to obtain the hair growth/blue hair promoter of the present invention.
ここで本発明に係る発毛・青毛促進料の有効成分として
含有される続随子、大観の生園エキスの一種または二種
の含有邑は０．１〜ｉｏ、ｏ重量％、好ましくは０．５
〜５．０重量％である。Here, the content of one or two of the extracts of Seizuji and Taikan Seien which are contained as active ingredients in the hair growth/greening hair promoting agent according to the present invention is 0.1 to io, o% by weight, preferably 0. .5
~5.0% by weight.
本発明に適用される続随子、大観よりの抽出生薬エキス
の一種または二種を含有する発毛・青毛促進料は下記の
表−１に示すマウスの毛成長の密度を測定する試験法王
において他の発毛・青毛促進科と言われている物質と比
較して顕著な効果が示されている。これは前記生薬より
の抽出生薬エキスの成分が毛根を刺激し、毛根周囲の血
行をより酪んにし、代謝をより良好にした結果である。The hair growth/green hair promoting agent containing one or two of the crude drug extracts from Setsuji and Taikan that is applied to the present invention was tested in a test method to measure the density of hair growth in mice as shown in Table 1 below. It has been shown to have a remarkable effect compared to other substances that are said to promote hair growth and green hair. This is because the components of the herbal medicine extract extracted from the herbal medicines stimulate the hair roots, making the blood circulation around the hair roots more stable and improving metabolism.
試験法王の簡単な説明
第９退会のＣａＨ系マウスを用いて、１群を１０匹とし
、４群作り、これらの背部の２．０ｃＩＩＸ ２．Ｏｃ
ｍの広さに除毛した部位に除毛後翌日検体を０．０２ｇ
塗布した後、９日目、１１日目、１４日目に当該部位の
毛成長の密度を色差計を用いて黒色増加度としてとらえ
、従来の比較物質としてのビタミンＥ及びコントロール
としての９９．５％エタノール溶液と比較する。Brief explanation of the test 9th withdrawal CaH mice were used to form 4 groups, with 10 mice per group, and 2.0cIIX on the back of these 2. Oc
The next day after hair removal, apply 0.02g of the sample to the area where the hair was removed in an area of m.
After application, on the 9th, 11th, and 14th day, the density of hair growth in the relevant area was measured as the degree of increase in black color using a colorimeter, and vitamin E was used as a conventional comparison substance and 99.5 as a control. % ethanol solution.
表−１毛成長の密度の測定
表−１において適用される各検体は、Ａは比較物質とし
てのビタミンＥ＠２重量％含有させた９９．５％エタノ
ール溶液、Ｂ、Ｃはそれぞれ続随子、大観のメタノール
抽出により得られた生薬エキスを５重量％含有させた９
９．５％エタノール溶液、Ｄはコントロールとしての９
９．５％エタノールである。Table 1 Measurement of Hair Growth Density The samples applied in Table 1 are as follows: A is a 99.5% ethanol solution containing 2% by weight of vitamin E as a comparison substance; 9 containing 5% by weight of crude drug extract obtained by methanol extraction of Taikan.
9.5% ethanol solution, D is 9 as a control
It is 9.5% ethanol.
次に臨床試験例を示す。Next, an example of a clinical trial is shown.
例 １
試料として続随子抽出生薬エキスを２重量％含有させた
９９．５％エタノール溶液を用いた。Example 1 As a sample, a 99.5% ethanol solution containing 2% by weight of a herbal medicine extract extracted from the cassava was used.
後頭部に直径３ａｘの脱毛部位を有する年令４４才の女
性の円形脱毛症患者に検体を１日１回、１回に３〜５ｇ
塗布したところ、約３ケ月侵には脱毛部位に短いうぶ毛
を生じ６ケ月後には硬毛となり脱毛部位は消失した。A 44-year-old female alopecia areata patient with a hair loss area of 3ax in diameter on the back of her head was given a sample once a day, 3 to 5 g at a time.
When applied, short downy hairs appeared in the bald area after about 3 months, and after 6 months, the bald hair turned into terminal hair and disappeared.
例 ２
試料として続随子抽出生薬エキスと大戦抽出生薬エキス
を１：１の比率で混合したものを２重量％含有させた９
９．５％エタノール溶液を用いた。Example 2 A sample containing 2% by weight of a 1:1 mixture of a herbal medicine extract extracted from a cassava and a crude medicine extract extracted from the Great War9.
A 9.5% ethanol solution was used.
頭頂部及び側頭部にそれぞれ２．５Ｃｔｔｔの脱毛部位
を右する年令３Ｂ才の男性の円形脱毛症患者に検体を１
日１回、１回に３〜５ｇ！［したところ、３ケ月後頭頂
部及び側頭部の脱毛部位にうぶ毛を生じ、６ケ月侵には
硬毛を生じたが完治までには至らなかった。One sample was given to a 3B-year-old male alopecia areata patient who had hair loss areas of 2.5 Cttt on the top and sides of the head, respectively.
3-5g once a day! [After 3 months, downy hair appeared on the hair loss site on the parietal and temporal regions, and after 6 months, terminal hair developed, but complete recovery was not achieved.
例１、例２ともに６ケ月間の連続塗布による皮膚障害は
全く認められなかった。In both Examples 1 and 2, no skin damage was observed after continuous application for 6 months.
次に処方実施例を示す。配合割合は重量品である。Next, prescription examples will be shown. The blending ratio is based on weight.
実施例１ ヘアトニック
続随子抽出生薬エキス ２．０メントール
０．２９９．５％エタノール
６０．０精 製 水
３７．８製法
９９．５％エタノールに続随子抽出生薬エキス、メント
ールを溶かしておき次に精製水を加えてＩＩＪ造する。Example 1 Hair tonic cassava extract crude drug extract 2.0 Menthol 0.299.5% ethanol 60.0 Purified water
37.8 Manufacturing method Dissolve the herbal extract and menthol in 99.5% ethanol and then add purified water to produce IIJ.
実施例２ ヘアクリーム
大戦抽出生薬エキス １．０ワセリン
７．０
蜜 ロ ウ
８．０クリストール
３７．０乳 化 剤
５，５精 製 水
４１．５製法
大戦抽出生薬エキス、ワセリン、蜜ロウ、クリストール
、乳化剤を混合して８０℃で溶解し、次で８０℃の精製
水を油相に徐々に加えクリーム状とする。Example 2 Hair Cream Taisen Herbal Medicine Extract 1.0 Vaseline
7.0 Honey Ro
8.0 Krystal
37.0 emulsifier
5.5 Purified water
41.5 Manufacturing method The Taisen crude drug extract, vaseline, beeswax, Crystol, and emulsifier are mixed and dissolved at 80°C. Next, purified water at 80°C is gradually added to the oil phase to form a cream.
実施例３ 軟 膏
続随子抽出生薬エキス ０．５大戟抽出生
薬エキス １．０イソプロピルミリス
テート １０．０セタノール
２．０パラフインロウ
６．０マイクロクリスタンリンロウ １０．０乳
化 剤
１１．Ｏ精 製 水
５９．５製 法
続随子及び大戦抽出生薬エキス、イソプロピルミリステ
ート、セタノール、パラフィンロウ、マイクロクリスタ
ンリンロウ、乳化剤を加熱溶融し、別に７０℃以上に加
熱した精製水を加えて撹拌し、４０℃まで撹拌しながら
冷却する。Example 3 Ointment Herbal medicine extract 0.5 Daigeki extract crude drug extract 1.0 Isopropyl myristate 10.0 Cetanol
2.0 paraffin wax
6.0 Microcrystalline wax 10.0 Emulsifier
11. O purified water
59.5 Manufacturing method Heat and melt the Zizzizi and Great War extracted crude drug extract, isopropyl myristate, cetanol, paraffin wax, microcrystalline wax, and emulsifier, add purified water heated to 70°C or higher and stir, Cool with stirring to °C.
Claims (1)
の種子）または大戟（Ｋｎｏｘｉａ ｃｏｒｙｍｂｏｓ
ａ Ｗ＿Ｉ ＿Ｌ＿Ｌ ＿Ｄ．またはＥｕｐｈ−ｏｒｂ
ｉａ ｓｉｅｂｏｌｄｉａｎａ Ｍ＿Ｏ ＿Ｒ＿Ｒ．ｅ
ｔ Ｄ＿Ｅ ＿Ｃ＿Ｎ ＿Ｅ．の根）の生薬から水溶性
有機溶媒単独またはこれらの含水有機溶媒により抽出し
た有効成分を一種または二種含有することを特徴とする
発毛・育毛促進料Euphorbia lathyris L.
Seeds of Knoxia corymbos) or Knoxia corymbos
a W_I _L_L _D. or Euph-orb
ia sieboldiana M_O_R_R. e
t D_E _C_N _E. A hair growth/hair growth promoting agent characterized by containing one or two active ingredients extracted from the herbal medicine of the root of the root of the root of the disease using a water-soluble organic solvent alone or with these water-containing organic solvents.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62031250A JPS63198612A (en) | 1987-02-13 | 1987-02-13 | Trichogenous hair-growing agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62031250A JPS63198612A (en) | 1987-02-13 | 1987-02-13 | Trichogenous hair-growing agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS63198612A true JPS63198612A (en) | 1988-08-17 |
Family
ID=12326118
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62031250A Pending JPS63198612A (en) | 1987-02-13 | 1987-02-13 | Trichogenous hair-growing agent |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS63198612A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0674897A2 (en) * | 1994-03-31 | 1995-10-04 | Shiseido Company Limited | Hair composition |
| CN1093195C (en) * | 1998-01-29 | 2002-10-23 | 三洋电机株式会社 | Washing machine |
-
1987
- 1987-02-13 JP JP62031250A patent/JPS63198612A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0674897A2 (en) * | 1994-03-31 | 1995-10-04 | Shiseido Company Limited | Hair composition |
| EP0674897A3 (en) * | 1994-03-31 | 1996-03-27 | Shiseido Co Ltd | Hair composition. |
| CN1093195C (en) * | 1998-01-29 | 2002-10-23 | 三洋电机株式会社 | Washing machine |
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