JPS54117468A - Pyrrolidine derivative - Google Patents

Pyrrolidine derivative

Info

Publication number: JPS54117468A
Authority: JP; Japan
Prior art keywords: pyrrolidine derivative; pyrrolidine; derivative
Prior art date: 1978-02-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP1288079A

Other languages

English (en)

Other versions

JPS6059907B2 (ja

Inventor

Kiburutsu Emirio

Ashiyubanden Berunaa

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

F Hoffmann La Roche AG

Original Assignee

F Hoffmann La Roche AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-02-10

Filing date

1979-02-08

Publication date

1979-09-12

1979-02-08 Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG

1979-09-12 Publication of JPS54117468A publication Critical patent/JPS54117468A/ja

1985-12-27 Publication of JPS6059907B2 publication Critical patent/JPS6059907B2/ja

Status Expired legal-status Critical Current

Links

FKCMADOPPWWGNZ-YUMQZZPRSA-N [(2r)-1-[(2s)-2-amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid Chemical compound CC(C)[C@H](N)C(=O)N1CCC[C@H]1B(O)O FKCMADOPPWWGNZ-YUMQZZPRSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/38—2-Pyrrolones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
General Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Psychiatry (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hospice & Palliative Care (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)

JP54012880A 1978-02-10 1979-02-08 ピロリジン誘導体 Expired JPS6059907B2 (ja)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
CH140378		1978-02-10
CH1403/78		1978-02-10
CH11981/78		1978-11-22
CH1198178		1978-11-22

Publications (2)

Publication Number	Publication Date
JPS54117468A true JPS54117468A (en)	1979-09-12
JPS6059907B2 JPS6059907B2 (ja)	1985-12-27

Family

ID=25687541

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP54012880A Expired JPS6059907B2 (ja)	1978-02-10	1979-02-08	ピロリジン誘導体

Country Status (34)

Country	Link
US (1)	US4369139A (ja)
EP (2)	EP0044088B1 (ja)
JP (1)	JPS6059907B2 (ja)
AR (1)	AR220739A1 (ja)
AT (1)	AT374787B (ja)
AU (1)	AU525514B2 (ja)
BG (1)	BG29281A3 (ja)
BR (1)	BR7900684A (ja)
CA (1)	CA1100515A (ja)
CS (1)	CS226182B2 (ja)
CU (1)	CU21107A3 (ja)
DD (1)	DD141828A5 (ja)
DE (1)	DE2963321D1 (ja)
DK (1)	DK155278C (ja)
EG (1)	EG13873A (ja)
ES (2)	ES477587A1 (ja)
FI (1)	FI69063C (ja)
GR (1)	GR71464B (ja)
HK (1)	HK6185A (ja)
HU (1)	HU177644B (ja)
IE (1)	IE47831B1 (ja)
IL (1)	IL56587A0 (ja)
IN (1)	IN150106B (ja)
MC (1)	MC1257A1 (ja)
MY (1)	MY8500340A (ja)
NO (1)	NO152046C (ja)
NZ (1)	NZ189571A (ja)
OA (1)	OA06180A (ja)
PH (1)	PH15491A (ja)
PL (1)	PL115958B1 (ja)
PT (1)	PT69206A (ja)
RO (1)	RO76615A (ja)
SU (1)	SU931104A3 (ja)
YU (1)	YU41330B (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7608636B2 (en)	2000-12-28	2009-10-27	Hamilton Pharmaceuticals, Inc.	Medicines for treatment and prevention of neurogenic pain

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1131959B (it) *	1979-08-09	1986-06-25	Hoffmann La Roche	Derivati pirrolidinici
CH646149A5 (de) *	1981-02-05	1984-11-15	Hoffmann La Roche	Pyrrolidin-derivat.
US4398938A (en) *	1982-05-20	1983-08-16	Velsicol Chemical Corporation	N-Acylated lactams and their herbicidal compositions and method of use
DE3326724A1 (de) *	1983-07-25	1985-02-07	Boehringer Ingelheim KG, 6507 Ingelheim	In 1-stellung substituierte 4-hydroxymethyl-pyrrolidinone, verfahren zu ihrer herstellung, pharmazeutische zusammensetzungen und zwischenprodukte
DE3336024A1 (de) *	1983-10-04	1985-04-18	Boehringer Ingelheim KG, 6507 Ingelheim	4-amino-l-benzyl-pyrrolidinone und ihre saeureadditionssalze, verfahren zu ihrer herstellung und arzneimittel
DE3420193A1 (de) *	1984-05-30	1985-12-05	Boehringer Ingelheim KG, 6507 Ingelheim	Neue substituierte pyrrolidinone, verfahren zu ihrer herstellung und arzneimittel
CH661174GA3 (ja) *	1985-07-10	1987-07-15
US4691853A (en) *	1985-12-30	1987-09-08	Technalytics, Inc.	Surgical stapler
US4760083A (en) *	1986-04-10	1988-07-26	E. I. Dupont De Nemours & Company	3,3-disubstituted indolines
US5300642A (en) *	1986-04-10	1994-04-05	The Du Pont Merck Pharmaceutical Company	α, α-disubstituted aromatics and heteroaromatics as cognition enhancers
US5173489A (en) *	1986-04-10	1992-12-22	The Dupont Merck Pharmaceutical Co.	α,α-disubstituted aromatics and heteroaromatics as cognition enhancers
US4876259A (en) *	1987-01-05	1989-10-24	E. I. Du Pont De Nemours And Company	3,3-disubstituted indolines
IT1215587B (it) *	1987-06-26	1990-02-14	Roussel Maestretti Spa	Derivati della 1-benzoil2-oxo 5-alcossi pirrolidina, loro procedimento di preparazione e loro impiego come sostanza medicinale.
CA1305148C (en) *	1987-08-19	1992-07-14	Hiromu Matsumura	Carbamoylpyrrolidone derivatives and drugs for senile dementia
US5202345A (en) *	1987-08-19	1993-04-13	Shionogi & Co., Ltd.	Carbamoylpyrrolidone derivatives and drugs for senile dementia
JP2585086B2 (ja) *	1988-12-28	1997-02-26	大鵬薬品工業株式会社	ジアザビシクロアルカン誘導体
IT1231921B (it) *	1989-06-12	1992-01-15	Sigma Tau Ind Farmaceuti	1-acil-2-pirrolidoni quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti
JP2803882B2 (ja) *	1990-02-20	1998-09-24	日清製粉株式会社	１―フエノキシカルボニル―２―ピロリジノン誘導体
JP3038032B2 (ja) *	1991-03-25	2000-05-08	日清製粉株式会社	血小板凝集抑制薬
NZ255097A (en) *	1992-07-24	2001-04-27	Univ California	Heterocyclic derivatives (such as 1-(1,4-bgenzodioxan-5-ylcarbonyl)-1,2,3,6-tetrahydropyridine) and medicaments that enhance synaptic responses
US5852008A (en) *	1995-01-24	1998-12-22	The Regents Of The University Of California	Heteroatom substituted benzoyl derivatives that enhance synaptic response mediated by receptors
CA2212829A1 (en) *	1995-02-21	1996-08-29	Jiro Takeo	Glutamic acid receptor agonist
IT1318490B1 (it) *	1999-04-27	2003-08-25	Hoffmann La Roche	Agente per fare aumentare la cessione di acetilcolina cerebrale.
US8858594B2 (en) *	2008-12-22	2014-10-14	Abbott Laboratories	Curved closure device
EP2604592B1 (en)	2011-12-12	2014-10-08	Zaklady Farmaceutyczne Polpharma SA	A process for the purification of aniracetam by crystallisation from aqueous solutions
CN109651222A (zh) *	2018-12-21	2019-04-19	上海昊航化工有限公司	一种阿尼西坦的催化合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3697563A (en) *	1970-06-29	1972-10-10	Inst Chemioterapico Italiano S	(3,4,5-trimethoxy-benzamido)-alkanoic acids for prophylaxis and treatment of cardiac disorders
DE2413935A1 (de) *	1974-03-20	1975-10-16	Schering Ag	4-(polyalkoxy-phenyl)-2-pyrrolidone
ES433723A1 (es) *	1975-01-10	1976-11-16	Lafarquim S A Lab	Procedimiento de obtencion de un derivado de 2-pirrolidi- nona.

1978
- 1978-01-25 CU CU7835021A patent/CU21107A3/xx unknown
1979
- 1979-01-01 AR AR22073979D patent/AR220739A1/es active
- 1979-01-10 IN IN27/CAL/79A patent/IN150106B/en unknown
- 1979-01-11 CA CA319,509A patent/CA1100515A/en not_active Expired
- 1979-01-16 EG EG26/79A patent/EG13873A/xx active
- 1979-01-24 FI FI790226A patent/FI69063C/fi not_active IP Right Cessation
- 1979-01-25 PH PH22107A patent/PH15491A/en unknown
- 1979-02-05 BR BR7900684A patent/BR7900684A/pt unknown
- 1979-02-05 NZ NZ189571A patent/NZ189571A/en unknown
- 1979-02-05 IL IL56587A patent/IL56587A0/xx not_active IP Right Cessation
- 1979-02-05 AU AU43916/79A patent/AU525514B2/en not_active Expired
- 1979-02-07 HU HU79HO2135A patent/HU177644B/hu not_active IP Right Cessation
- 1979-02-08 YU YU283/79A patent/YU41330B/xx unknown
- 1979-02-08 OA OA56728A patent/OA06180A/xx unknown
- 1979-02-08 RO RO7996556A patent/RO76615A/ro unknown
- 1979-02-08 GR GR58300A patent/GR71464B/el unknown
- 1979-02-08 SU SU792719854A patent/SU931104A3/ru active
- 1979-02-08 JP JP54012880A patent/JPS6059907B2/ja not_active Expired
- 1979-02-08 BG BG7942414A patent/BG29281A3/xx unknown
- 1979-02-08 CS CS79881A patent/CS226182B2/cs unknown
- 1979-02-08 MC MC791362A patent/MC1257A1/xx unknown
- 1979-02-09 EP EP81106674A patent/EP0044088B1/de not_active Expired
- 1979-02-09 PT PT7969206A patent/PT69206A/pt unknown
- 1979-02-09 IE IE246/79A patent/IE47831B1/en not_active IP Right Cessation
- 1979-02-09 ES ES477587A patent/ES477587A1/es not_active Expired
- 1979-02-09 DK DK056379A patent/DK155278C/da not_active Application Discontinuation
- 1979-02-09 DE DE7979100379T patent/DE2963321D1/de not_active Expired
- 1979-02-09 NO NO790434A patent/NO152046C/no unknown
- 1979-02-09 DD DD79210944A patent/DD141828A5/de unknown
- 1979-02-09 AT AT0099579A patent/AT374787B/de not_active IP Right Cessation
- 1979-02-09 EP EP79100379A patent/EP0005143B1/de not_active Expired
- 1979-02-10 PL PL1979213340A patent/PL115958B1/pl unknown
- 1979-08-31 ES ES483756A patent/ES483756A1/es not_active Expired
1980
- 1980-07-14 US US06/168,906 patent/US4369139A/en not_active Expired - Lifetime
1985
- 1985-01-24 HK HK61/85A patent/HK6185A/xx unknown
- 1985-12-30 MY MY340/85A patent/MY8500340A/xx unknown

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7608636B2 (en)	2000-12-28	2009-10-27	Hamilton Pharmaceuticals, Inc.	Medicines for treatment and prevention of neurogenic pain

Also Published As

Publication number	Publication date
BG29281A3 (en)	1980-10-15
JPS6059907B2 (ja)	1985-12-27
IN150106B (ja)	1982-07-24
FI69063C (fi)	1985-12-10
DE2963321D1 (en)	1982-09-02
NO152046B (no)	1985-04-15
CS226182B2 (en)	1984-03-19
PH15491A (en)	1983-01-31
EP0005143B1 (de)	1982-07-14
EP0044088B1 (de)	1984-02-22
EP0044088A3 (en)	1982-02-03
IE47831B1 (en)	1984-06-27
NO790434L (no)	1979-08-13
YU28379A (en)	1983-02-28
IL56587A0 (en)	1979-05-31
CA1100515A (en)	1981-05-05
NZ189571A (en)	1984-07-06
GR71464B (ja)	1983-05-30
EP0005143A1 (de)	1979-11-14
MY8500340A (en)	1985-12-31
US4369139A (en)	1983-01-18
DK56379A (da)	1979-08-11
ES483756A1 (es)	1980-04-16
ATA99579A (de)	1983-10-15
MC1257A1 (fr)	1980-01-14
YU41330B (en)	1987-02-28
EP0044088A2 (de)	1982-01-20
SU931104A3 (ru)	1982-05-23
AU525514B2 (en)	1982-11-11
EG13873A (en)	1982-12-31
PL115958B1 (en)	1981-05-30
CU21107A3 (es)	1988-02-01
DK155278C (da)	1989-07-24
NO152046C (no)	1985-07-24
FI69063B (fi)	1985-08-30
HU177644B (en)	1981-11-28
AU4391679A (en)	1979-08-16
OA06180A (fr)	1981-06-30
DK155278B (da)	1989-03-20
ES477587A1 (es)	1980-01-16
AT374787B (de)	1984-05-25
DD141828A5 (de)	1980-05-21
PT69206A (en)	1979-03-01
FI790226A (fi)	1979-08-11
HK6185A (en)	1985-02-01
PL213340A1 (ja)	1980-03-24
IE790246L (en)	1979-08-20
BR7900684A (pt)	1979-09-04
AR220739A1 (es)	1980-11-28
RO76615A (ro)	1981-04-30

Legal Events

Date	Code	Title	Description
2004-02-08	EXPY	Cancellation because of completion of term

Publication	Publication Date	Title
JPS54117468A (en)	1979-09-12	Pyrrolidine derivative
JPS54109975A (en)	1979-08-29	Thienohydantoin derivative
JPS54141798A (en)	1979-11-05	44desacetyl vlboo33carboxyhydrazide derivative
JPS54119450A (en)	1979-09-17	2hhbenzofurann33one derivative
JPS54132627A (en)	1979-10-15	Cumalin derivative
JPS5527193A (en)	1980-02-27	Spiroofuranohydantoin derivative
JPS54117469A (en)	1979-09-12	Pyrrolidine derivative
JPS54151966A (en)	1979-11-29	Nnsubstituted oxobenzothiazoline derivative
PH17055A (en)	1984-05-17	Delta4-androstenes derivative
GB2055835B (en)	1983-07-06	Pyrrolidine derivatives
JPS54128570A (en)	1979-10-05	Arylaminoimidazoline derivative
JPS5543080A (en)	1980-03-26	22oxazolin derivative
JPS54163596A (en)	1979-12-26	Flonaphlizine derivative
JPS54109991A (en)	1979-08-29	111alkanoyll4*deoxyy4*isonitroooleandomycin derivative
JPS5581835A (en)	1980-06-20	Novel pentenee22yl derivative
JPS557262A (en)	1980-01-19	Novel bettaine derivative
JPS5559166A (en)	1980-05-02	Pyrrolidine derivative and its manufacture
JPS54154775A (en)	1979-12-06	Benzylpyrimidine derivative
JPS54151967A (en)	1979-11-29	Nnsubstituted oxobenzothiazoline derivative
JPS54122232A (en)	1979-09-21	Phenylnitramine derivative
MTP839B (en)	1980-01-24	Pyrrolidine derivative
JPS54163597A (en)	1979-12-26	Floquinoline derivative
JPS5572187A (en)	1980-05-30	Perhydroo1*33thiazine derivative
JPS5626872A (en)	1981-03-16	Pyrrolidine derivative
JPS54157551A (en)	1979-12-12	Indanamine derivative

JPS54117468A - Pyrrolidine derivative - Google Patents

Info

Links

Classifications

Landscapes

Applications Claiming Priority (4)

Publications (2)

Family

ID=25687541

Family Applications (1)

Country Status (34)

Cited By (1)

Families Citing this family (26)

Family Cites Families (3)

Cited By (1)

Also Published As

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Legal Events